CN107603877B - High-precision temperature control system with temperature prediction function for stem cell preparation environment - Google Patents
High-precision temperature control system with temperature prediction function for stem cell preparation environment Download PDFInfo
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- CN107603877B CN107603877B CN201710708126.8A CN201710708126A CN107603877B CN 107603877 B CN107603877 B CN 107603877B CN 201710708126 A CN201710708126 A CN 201710708126A CN 107603877 B CN107603877 B CN 107603877B
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Abstract
The invention provides a high-precision temperature control system with temperature prediction for a stem cell preparation environment, and provides a temperature prediction method, which comprises the steps of acquiring and storing environment temperature information and acquisition time in real time, and predicting the temperature change trend of the stem cell preparation environment; the method comprises the steps of obtaining the change trend of the stem cell preparation environment temperature, fine-tuning the environment temperature in advance, and detecting the change trend of the stem cell preparation environment temperature in the fine-tuning environment temperature in advance until the change trend is smaller than a given threshold value; the invention also provides a high-precision temperature control system with temperature prediction for a stem cell preparation environment, which consists of a temperature sensor, a memory, a central controller and a temperature regulator.
Description
Technical Field
The invention relates to a temperature control system, in particular to a high-precision temperature control system for a stem cell preparation environment.
Background
The stem cell preparation is precise and delicate, the stem cell preparation environment has strict requirements on environment cleanliness, humidity, temperature and the like, and the conventional general temperature control system is lack of advance prediction on the environment through temperature error adjustment, so that the temperature adjustment oscillation is large, the precision and the stability are low, and the stem cell preparation is not facilitated. In order to solve the problems, the invention designs a high-precision temperature control system with temperature prediction for a stem cell preparation environment.
Disclosure of Invention
The invention aims to provide a high-precision temperature control system with a temperature prediction function for a stem cell preparation environment.
The invention is realized by the following technical scheme:
a method of temperature prediction comprising the steps of: the method comprises the steps of acquiring stem cell preparation environment temperature information in real time, storing the stem cell preparation environment temperature and collecting timestamp information, and predicting the stem cell preparation environment temperature change trend.
The acquired stem cell preparation environment temperature information c and the acquired time stamp information t are stored in a data pair [ t, c ] form, the temperature change trend (10 s in the future) is accurately estimated according to the target, historical data within 20s are selected, the accuracy improvement on the predicted temperature change trend is higher when the time is closer to the current time, and conversely, the more distant historical temperature records are helpful for estimating the instantaneous change of the temperature and are beneficial to the overall change trend of the temperature. Therefore, according to the principle that the closer to the current time, the more dense the sampling points are, the historical data is selected according to the following formula:
in the above formula, i represents the number of selected historical data points, tiTo select the ith data time information, t0Is the current time. From the above equation, the selected historical data points have 32 points (including the current time). For selecting 32 pairs of data
Matching is performed by using a 31-order polynomial, wherein the expression is as follows:
in the formula, ajIs a polynomial parameter.
Predicting the temperature by using the matched polynomial, and outputting a prediction result according to the input timestamp (within 10s at a certain moment after the current timestamp)
Rate of change at present time
When in use
When the temperature is reduced, the temperature is in an increasing trend; when in use
The temperature will tend to decrease.
A high-precision temperature adjusting method comprises the following steps: obtaining the change trend of the stem cell preparation environment temperature, finely adjusting the environment temperature in advance, and detecting and obtaining the change trend of the stem cell preparation environment temperature until the change trend is smaller than a given threshold value.
Method for acquiring real-time change trend of stem cell preparation environment temperature by adopting temperature prediction method
And predicting the temperature
Suppose that at time t0A target temperature of + Δ t of
The error is then:
when delta is larger than 0, the predicted temperature is higher than the target temperature, and the system needs to be cooled;
when delta is less than 0, the predicted temperature is lower than the target temperature, and the system needs to be warmed.
Comprehensively considering error delta and variation trend
The ambient temperature was fine-tuned as follows:
the first condition is as follows: if delta is 0, the environment is not processed, the environment temperature is detected in real time, and the environment temperature and the change trend are predicted;
case two: if Δ > 0 and
cooling the environment, detecting the environment temperature in real time and predicting the environment temperature and the variation trend;
case three: if Δ > 0 and
does not perform any processing on the environmentDetecting the ambient temperature and predicting the ambient temperature and the variation trend;
case four: if Δ < 0 and
carrying out temperature rise treatment on the environment, detecting the environment temperature in real time and predicting the environment temperature and the change trend;
case five: if Δ < 0 and
the environment is not processed, the environment temperature is detected in real time, and the environment temperature and the change trend are predicted;
and (4) fine-tuning the environment according to the new environment predicted temperature, error and change trend until delta is 0 and the change trend is smaller than a threshold value.
The invention also provides a high-precision temperature control system with temperature prediction for a stem cell preparation environment, which comprises:
and the temperature sensor is used for monitoring the stem cell preparation environment temperature and the timestamp information in real time.
And the memory is used for storing historical temperature information monitored by the temperature sensor and corresponding timestamp information.
And the central controller stores data by using a memory and sends out a temperature adjusting instruction according to a temperature predicting method and a high-precision temperature adjusting method.
And the temperature regulator receives a temperature regulation instruction sent by the central controller and finely regulates the ambient temperature.
Compared with the existing temperature control system for the stem cell preparation environment, the invention has the following beneficial effects:
according to the invention, long-time historical data is adopted, and a prediction sample is selected to predict the temperature in the near time according to the principle that the closer the time is, the more the change is, the closer the change is, so that the high temperature prediction precision can be obtained;
according to the temperature error adjusting system and the temperature error adjusting method, the temperature is finely adjusted and controlled in advance according to the prediction result and the variation trend, so that the temperature is kept and is slightly vibrated in the adjusting process, and the stability and the accuracy are better compared with the traditional temperature error adjusting system.
Drawings
The invention is further illustrated with reference to the following figures and examples:
FIG. 1 is a diagram of a high-precision temperature control system with temperature prediction for a stem cell preparation environment according to the present invention.
FIG. 2 is a flow chart of a high-precision temperature regulation strategy of the present invention.
Detailed Description
The present invention is described in detail below by way of examples, it should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and those skilled in the art can make some insubstantial modifications and adaptations of the present invention based on the above-described disclosure.
As shown in fig. 1, a high-precision temperature control system with temperature prediction for a stem cell preparation environment is provided, wherein temperature sensors are arranged at a plurality of collection points in the stem cell preparation environment, the environment is monitored for temperature according to a cycle of 1ms and a precision of 0.01 ℃, and monitored temperature and timestamp information are transmitted to a memory;
the memory receives the monitored temperatures and the timestamp information sent by all the temperature sensors, performs mean value combination on the monitored temperatures with the same timestamp information, and stores the monitored temperatures in a data pair form;
the central controller takes 1s as a period, according to a temperature prediction method, according to the principle that the closer the time is, the greater the correlation is, 32 pairs of historical data within 20s are read by a memory, a 31-order polynomial is adopted to carry out matching prediction on a temperature change curve, and the temperature within 10s in the future is predicted
And current rate of temperature change
Calculating temperature error by combining high-precision temperature regulation method
And sends out a temperature regulation instruction according to the high-precision temperature regulation strategy as shown in FIG. 2;
and arranging temperature regulators at a plurality of temperature regulation points in the stem cell preparation environment, uniformly receiving temperature regulation instructions of the central controller, and finely adjusting the environment temperature according to the temperature regulation instructions.
Claims (7)
1. A method of temperature prediction, characterized by:
acquiring stem cell preparation environment temperature information in real time, storing the stem cell preparation environment temperature and collecting timestamp information, and predicting the stem cell preparation environment temperature change trend;
the stem cell preparation environment temperature information is obtained in real time, a method of obtaining the stem cell environment temperature information by a plurality of collecting points and calculating the mean value is used for obtaining the stem cell preparation environment temperature information, and the temperature precision is 0.01 ℃;
the storage stem cell preparation environment temperature and collection timestamp information, the temperature collection and storage period is 1ms, and data pair [ t, c ] form storage is adopted;
the method is used for predicting the change trend of the stem cell preparation environment temperature and the using rule
Selecting 32 pairs of historical data within 20s as prediction samples, and adopting a 31-order polynomial
Fitting the prediction sample to obtain a temperature change curve, namely predicting the temperature after the delta t moment
And current rate of temperature change
The current temperatureRate of change
When in use
When the temperature is reduced, the temperature is in an increasing trend; when in use
The temperature will tend to decrease.
2. A high-precision temperature adjustment method based on the temperature prediction method according to claim 1, characterized in that:
obtaining the change trend of the temperature of the stem cell preparation environment, finely adjusting the temperature of the stem cell preparation environment in advance, detecting and obtaining the change trend of the temperature of the stem cell preparation environment, and finely adjusting;
the method for acquiring the change trend of the stem cell preparation environment temperature comprises the step of acquiring the current temperature change rate according to the temperature prediction method
And predicting the temperature
Suppose that at time t0A target temperature of + Δ t of
The error is then:
when delta is larger than 0, the predicted temperature is higher than the target temperature, and the system needs to be cooled;
when the delta is less than 0, the predicted temperature is lower than the target temperature, and the system needs to be heated;
the environmental temperature is finely adjusted in advance, and the error is calculated
Adjusting the temperature by using a high-precision temperature adjustment strategy;
the high-precision temperature adjustment strategy is as follows:
the first condition is as follows: if delta is 0, the environment is not processed, the environment temperature is detected in real time, and the environment temperature and the change trend are predicted;
case two: if Δ > 0 and
cooling the environment, detecting the environment temperature in real time and predicting the environment temperature and the variation trend;
case three: if Δ > 0 and
the environment is not processed, the environment temperature is detected in real time, and the environment temperature and the change trend are predicted;
case four: if Δ < 0 and
carrying out temperature rise treatment on the environment, detecting the environment temperature in real time and predicting the environment temperature and the change trend;
case five: if Δ < 0 and
and (3) carrying out no treatment on the environment, detecting the environment temperature in real time and predicting the environment temperature and the variation trend.
3. A high-precision temperature control system based on the high-precision temperature regulation method according to claim 2, characterized in that:
the high-precision temperature control system consists of a temperature sensor, a memory, a central controller and a temperature regulator;
the temperature sensor is used for monitoring the stem cell preparation environment temperature and the timestamp information in real time;
the memory is used for storing historical temperature information of the temperature sensor in a data pair form and corresponding timestamp information;
the central controller reads the storage data of the memory, sends out a temperature adjusting instruction according to a temperature prediction method and a high-precision temperature adjusting method, and contains an operating instruction for heating or cooling the temperature;
the temperature regulator receives a temperature regulation instruction sent by the central controller and finely adjusts the ambient temperature according to the temperature regulation instruction.
4. The high-precision temperature control system according to claim 3, characterized in that: the temperature sensor detects the temperature with the precision of 0.01 ℃ and the monitoring time period is 1 ms.
5. The high-precision temperature control system according to claim 3, characterized in that: the central controller temperature prediction and temperature regulation instruction sending time period is 1 s.
6. The high-precision temperature control system according to claim 3, characterized in that: the temperature sensors are respectively arranged at different collection points of a stem cell preparation environment, and the storage device is used for carrying out mean value combination and storage on the monitoring temperatures of the temperature sensors.
7. The high-precision temperature control system according to claim 3, characterized in that: the temperature regulator is arranged at a plurality of temperature regulation points in the stem cell preparation environment, uniformly receives a temperature regulation instruction sent by the central controller, and finely adjusts the environment temperature according to the temperature regulation instruction.
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| CN110399998A (en) * | 2018-04-24 | 2019-11-01 | 沃司科技股份有限公司 | Cold Chain Logistics early warning system and its method |
| CN110129198A (en) * | 2019-05-15 | 2019-08-16 | 林伟阳 | A kind of stem cell neural network based culture simulated environment data monitoring and prediction embedded subsystem |
| CN117407728B (en) * | 2023-12-15 | 2024-03-15 | 湖南南华生物技术有限公司 | Storage environment real-time monitoring method and system for stem cells |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202286005U (en) * | 2011-10-09 | 2012-07-04 | 协和干细胞基因工程有限公司 | Stem cell storage tank with liquid level and temperature monitoring devices |
| CN205473815U (en) * | 2015-12-31 | 2016-08-17 | 深圳市第二人民医院 | Stem cell strorage device |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202286005U (en) * | 2011-10-09 | 2012-07-04 | 协和干细胞基因工程有限公司 | Stem cell storage tank with liquid level and temperature monitoring devices |
| CN205473815U (en) * | 2015-12-31 | 2016-08-17 | 深圳市第二人民医院 | Stem cell strorage device |
Non-Patent Citations (1)
| Title |
|---|
| CSCBTM: China Stem Cell Bank Information;Yunlong Ma 等;《2010 Second WRI Global Congress on Intelligent Systems》;20101231;410-413 * |
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Inventor after: Xiong Huaqiang Inventor after: Hu Xiaodong Inventor before: Zhao Xiang Inventor before: Xiong Huaqiang Inventor before: Hu Xiaodong |