CN107603877A - It is a kind of to prepare environment for stem cell there is the high-precision temperature control system of temperature prediction - Google Patents
It is a kind of to prepare environment for stem cell there is the high-precision temperature control system of temperature prediction Download PDFInfo
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- CN107603877A CN107603877A CN201710708126.8A CN201710708126A CN107603877A CN 107603877 A CN107603877 A CN 107603877A CN 201710708126 A CN201710708126 A CN 201710708126A CN 107603877 A CN107603877 A CN 107603877A
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Abstract
It is a kind of to prepare environment for stem cell there is the high-precision temperature control system of temperature prediction, the invention provides a kind of temperature predicting method, including obtain in real time and storage environment temperature information and acquisition time, prediction stem cell prepare variation of ambient temperature trend；Additionally provide a kind of high-precision temperature adjusting method, including obtain stem cell prepare variation of ambient temperature trend, finely tune environment temperature in advance, detection obtains stem cell and prepares variation of ambient temperature trend and finely tuning environment temperature in advance until variation tendency is less than given threshold value；Present invention also offers preparing environment for stem cell there is the high-precision temperature control system of temperature prediction, it is made up of temperature sensor, memory, central controller, thermoregulator.
Description
Technical field
The present invention relates to temperature control system, and in particular to a kind of high-precision temperature control system that environment is prepared for stem cell.
Background technology
Prepared by stem cell is a precision, careful work, and its stem cell prepares environment to environment cleanliness, humidity, temperature
Relatively it is strict with Deng having, existing general temperature control system is adjusted by temperature error, lacks the look-ahead to environment so that
Temperature adjustment vibration is larger, and precision and stability is relatively low, is unfavorable for the preparation of stem cell.It is to solve the above problems, of the invention
Devise and a kind of prepare environment for stem cell there is the high-precision temperature control system of temperature prediction.
The content of the invention
Present invention aims at provide a kind of high precision temperature control for being used for stem cell and preparing environment and possessing temperature prediction function
System.
The present invention is achieved through the following technical solutions：
A kind of temperature predicting method, comprises the following steps：Acquisition stem cell preparation ambient temperature information, storage are dry thin in real time
Born of the same parents prepare environment temperature and acquisition time stamp information, prediction stem cell prepare variation of ambient temperature trend.
The stem cell of acquisition prepares ambient temperature information c and timestamp information t, and [t, c] form is stored with data,
According to target, temperature changing trend (following 10s) is accurately estimated, choose the historical data within 20s, consider to get over from current time
Closely, it is bigger to predicted temperature variation tendency precision improvement, conversely, more remote historical temperature record is estimated the transient change of temperature
Help it is smaller, it is beneficial to the general morphologictrend of temperature.So following the principle more intensive from the nearlyer sampled point of current time, press
Historical data is chosen according to equation below：
In above formula, i represents to choose historical data point number, tiTo choose i-th of data time information, t0For current time.
It can be obtained according to above formula, the historical data point one of selection shares 32 points (including current time).For choosing 32 pairs of dataMatched using 31 rank multinomials, expression formula is as follows：
In formula, ajFor polynomial parameters.
The multinomial completed using matching is predicted to temperature, stabbed according to input time (certain moment after current time stamp,
Within 10s), export prediction resultCurrent time rate of changeWhenWhen, temperature drop is in rising trend；WhenWhen, temperature will be on a declining curve.
A kind of high-precision temperature adjusting method, it comprises the following steps：Acquisition stem cell preparation variation of ambient temperature trend,
Environment temperature is finely tuned in advance, detection obtains stem cell and prepares variation of ambient temperature trend until variation tendency is less than given thresholding
Value.
Stem cell is obtained using temperature predicting method and prepares environment temperature real-time change trendAnd predicted temperatureIt is false
It is scheduled on moment t0+ Δ t target temperature isThen error is：
As Δ ＞ 0, predicted temperature is higher than target temperature, and system needs to cool；
As Δ ＜ 0, predicted temperature is less than target temperature, and system needs to heat up.
Consider error delta and variation tendencyFollowing situation is divided to be finely adjusted environment temperature：
Situation one：If Δ=0, to environment without any processing, environment temperature is detected in real time and predicts environment
Temperature and variation tendency；
Situation two：If Δ ＞ 0 andCooling processing then is carried out to environment, in real time environment temperature detect and pre-
Survey environment temperature and variation tendency；
Situation three：If Δ ＞ 0 andTo environment without any processing, in real time environment temperature detect and pre-
Survey environment temperature and variation tendency；
Situation four：If Δ ＜ 0 andHeating treatment is carried out to environment, environment temperature is detected and predicted in real time
Environment temperature and variation tendency；
Situation five：If Δ ＜ 0 andTo environment without any processing, in real time environment temperature detect and pre-
Survey environment temperature and variation tendency；
It is finely adjusted according to new environmental forecasting temperature, error and variation tendency to environment, to Δ=0 and variation tendency
Less than threshold value.
Prepare environment present invention also offers a kind of for stem cell there is the high-precision temperature control system of temperature prediction, wrap
Include：
Temperature sensor, environment temperature and timestamp information are prepared for monitoring stem cell in real time.
Memory, for storage temperature Sensor monitoring historical temperature information and correspondent time information.
Central controller, using memory stores data, sent out according to temperature predicting method and high-precision temperature adjusting method
Go out temperature adjustment instructions.
Thermoregulator, the temperature adjustment instructions that central controller is sent are received, environment temperature is finely adjusted.
Compared with being currently used for stem cell and preparing the temperature control system of environment, the present invention has the advantages that：
The present invention use long-time historical data, and follow the time it is nearer change more phase approximately principle selection forecast sample to compared with
Temperature is predicted in the nearly time, can obtain very high temperature prediction precision；
The present invention is finely adjusted and controlled to temperature in advance according to prediction result and variation tendency so that temperature keeps and adjusted
Shake smaller during section, there is more preferable stability and precision compared to traditional temperature error regulating system.
Brief description of the drawings
The present invention is further described with reference to the accompanying drawings and examples：
Fig. 1 prepares environment for the present invention for stem cell has the high-precision temperature control system structure chart of temperature prediction.
Fig. 2 is that high-precision temperature of the present invention adjusts strategic process figure.
Embodiment
The present invention is specifically described below by embodiment, it is necessary to it is pointed out here that be that following examples are only used
It is further described in the present invention, it is impossible to be interpreted as limiting the scope of the invention, person skilled in art can
So that some nonessential modifications and adaptations are made to the present invention according to the invention described above content.
As shown in Figure 1 a kind of prepares environment for stem cell has the high-precision temperature control system of temperature prediction, dry thin
Born of the same parents prepare multiple collection points in environment and set temperature sensor, and according to cycle 1ms, 0.01 degree of precision enters trip temperature prison to environment
Survey, monitoring temperature and timestamp information are transmitted to memory；
Memory receives monitoring temperature and the timestamp information that all temperature sensors are sent, and to identical time stamp information
Monitoring temperature carry out average merging, form is stored according to data；
Central controller is using 1s as the cycle, according to temperature predicting method, according to the time bigger principle of nearlyer correlation, by depositing
Reservoir reads 32 pairs of historical datas within 20s, carries out matching predicted temperature change curve using 31 rank multinomials, predicts future
Temperature within 10sAnd Current Temperatures rate of changeCombined high precision temperature control method, calculate temperature and miss
DifferenceAnd send temperature adjustment instructions according to high-precision temperature as shown in Figure 2 regulation strategy；
Multiple temperature adjustment points set thermoregulator in stem cell prepares environment, uniformly receive central controller temperature
Regulating command is spent, and environment temperature is finely adjusted according to temperature adjustment instructions.
Claims (7)
- A kind of 1. temperature predicting method, it is characterised in that：Stem cell is obtained in real time and prepares ambient temperature information, storage stem cell preparation environment temperature and acquisition time stamp information, in advance Survey stem cell and prepare variation of ambient temperature trend；It is described to obtain stem cell preparation ambient temperature information in real time, obtain stem cell environment temperature information using multiple collection points and ask Mean Method prepares ambient temperature information as stem cell is obtained, and temperature accuracy is 0.01 degree；The storage stem cell prepares environment temperature and acquisition time stamp information, temperature acquisition and storage cycle 1ms, using data [t, c] form is stored；The prediction stem cell prepares variation of ambient temperature trend, uses rule32 pairs of historical datas are as forecast sample within selection 20s, and use 31 rank multinomialsForecast sample is entered Row fitting, obtains temperature variation curve, you can temperature after prediction time ΔtAnd Current Temperatures Rate of changeThe Current Temperatures rate of changeWhenWhen, temperature drop is in rising trend；WhenWhen, temperature will become in decline Gesture.
- A kind of 2. high-precision temperature adjusting method based on temperature predicting method as claimed in claim 1, it is characterised in that：Stem cell is obtained to prepare variation of ambient temperature trend, finely tune environment temperature in advance, detect again and obtain stem cell and prepare environment Temperature changing trend is simultaneously finely tuned；It is by described temperature predicting method that the acquisition stem cell, which prepares variation of ambient temperature trend, obtains Current Temperatures change RateAnd predicted temperatureIt is described to finely tune environment temperature, calculation error in advanceTemperature is entered using high-precision temperature regulation strategy Row regulation；The high-precision temperature adjusts strategy：Situation one：If Δ=0, to environment without any processing, environment temperature is detected in real time and predicts environment temperature And variation tendency；Situation two：If Δ ＞ 0 andCooling processing then is carried out to environment, to environment temperature detect simultaneously prediction loop in real time Border temperature and variation tendency；Situation three：If Δ ＞ 0 andTo environment without any processing, to environment temperature detect simultaneously prediction loop in real time Border temperature and variation tendency；Situation four：If Δ ＜ 0 andHeating treatment is carried out to environment, environment temperature is detected in real time and predicts environment Temperature and variation tendency；Situation five：If Δ ＜ 0 andTo environment without any processing, to environment temperature detect simultaneously prediction loop in real time Border temperature and variation tendency.
- A kind of 3. high-precision temperature control system based on high-precision temperature adjusting method as claimed in claim 2, it is characterised in that：Described high-precision temperature control system is made up of temperature sensor, memory, central controller, thermoregulator；The temperature sensor, environment temperature and timestamp information are prepared for monitoring stem cell in real time；The memory, for storage temperature Sensor monitoring historical temperature information and correspondent time to be believed in the form of by data Breath；The central controller, memory stores data is read, sent out according to temperature predicting method and high-precision temperature adjusting method Go out temperature adjustment instructions, containing being heated up to temperature or the operational order that cools；The thermoregulator, the temperature adjustment instructions that central controller is sent are received, and according to temperature adjustment instructions to environment Temperature is finely adjusted.
- 4. high-precision temperature control system as claimed in claim 3, it is characterised in that：Described temperature sensor detection temperature precision For 0.01 degree, the monitoring time cycle is 1ms.
- 5. high-precision temperature control system as claimed in claim 3, it is characterised in that：The central controller temperature prediction and temperature It is 1s that regulating command, which sends the time cycle,.
- 6. high-precision temperature control system as claimed in claim 3, it is characterised in that：The temperature sensor is located at respectively to be multiple Stem cell prepares environment different acquisition point, and the memory carries out average merging to multiple monitors temperatures and deposited Storage.
- 7. high-precision temperature control system as claimed in claim 3, it is characterised in that：The thermoregulator is arranged on stem cell system The multiple temperature adjustment points of standby environment, the unified temperature adjustment instructions for receiving central controller and sending, according to temperature adjustment instructions pair Environment temperature is finely adjusted.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110129198A (en) * | 2019-05-15 | 2019-08-16 | 林伟阳 | A kind of stem cell neural network based culture simulated environment data monitoring and prediction embedded subsystem |
| CN110399998A (en) * | 2018-04-24 | 2019-11-01 | 沃司科技股份有限公司 | Cold Chain Logistics early warning system and its method |
| CN117407728A (en) * | 2023-12-15 | 2024-01-16 | 湖南南华生物技术有限公司 | Storage environment real-time monitoring method and system for stem cells |
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| CN202286005U (en) * | 2011-10-09 | 2012-07-04 | 协和干细胞基因工程有限公司 | Stem cell storage tank with liquid level and temperature monitoring devices |
| CN205473815U (en) * | 2015-12-31 | 2016-08-17 | 深圳市第二人民医院 | Stem cell strorage device |
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| CN202286005U (en) * | 2011-10-09 | 2012-07-04 | 协和干细胞基因工程有限公司 | Stem cell storage tank with liquid level and temperature monitoring devices |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110399998A (en) * | 2018-04-24 | 2019-11-01 | 沃司科技股份有限公司 | Cold Chain Logistics early warning system and its method |
| CN110129198A (en) * | 2019-05-15 | 2019-08-16 | 林伟阳 | A kind of stem cell neural network based culture simulated environment data monitoring and prediction embedded subsystem |
| CN117407728A (en) * | 2023-12-15 | 2024-01-16 | 湖南南华生物技术有限公司 | Storage environment real-time monitoring method and system for stem cells |
| CN117407728B (en) * | 2023-12-15 | 2024-03-15 | 湖南南华生物技术有限公司 | Storage environment real-time monitoring method and system for stem cells |
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Inventor after: Xiong Huaqiang Inventor after: Hu Xiaodong Inventor before: Zhao Xiang Inventor before: Xiong Huaqiang Inventor before: Hu Xiaodong |