CN107596313A - A kind of preparation method for the Chinese medicine composition and its pill for treating coronary heart disease - Google Patents
A kind of preparation method for the Chinese medicine composition and its pill for treating coronary heart disease Download PDFInfo
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Abstract
The invention discloses a kind of preparation method for the Chinese medicine composition and its pill for treating coronary heart disease, the composition and its parts by weight of its bulk drug be, 100 150 parts of the red sage root, ripe 100 150 parts of pseudo-ginseng, 100 150 parts of borneol, 100 150 parts of the hedgehog heart, 80 120 parts of rhizome of chuanxiong, 80 120 parts of the Radix Astragali, 80 120 parts of pepper bar, 60 80 parts of ginseng, 60 80 parts of hairyvein agrimony, 60 80 parts of lepidium seed, 60 80 parts of cymbopogon distans, 60 80 parts of Hericium erinaceus, 40 60 parts of monkshood, 40 60 parts of amber, 40 60 parts of rhizoma nardostachyos, 10 20 parts of 40 60 parts of hawthorn, 10 20 parts of ginger and radix glycyrrhizae.Cardiac stimulant is basic in the prescription of the present invention, and nourishing heart shield heart is crucial, is aided with promoting blood circulation, sensible blood vessels.Monarch acts on each other, complements each other.
Description
Technical field
The present invention relates to the field of Chinese medicines, more particularly, to a kind of preparation for the Chinese medicine composition and its pill for treating coronary heart disease
Method.
Background technology
Coronary atherosclerotic heart disease is that coronary artery occurs atherosclerotic lesion and causes blood vessel
Chamber stenosis or occlusion, heart disease caused by myocardial ischemia, anoxic or necrosis is caused, be commonly referred to as " coronary heart disease ".But it is preced with
The scope of worry may more extensively, in addition to inflammation, embolism etc. cause luminal stenosis or occlusion.The World Health Organization is by coronary heart disease
It is divided into 5 major classes：Silent ischemia (latent coronary heart disease), angina pectoris, myocardial infarction, ischemic heart failure (ischemic
Heart disease) and 5 kinds of Clinical types of sudden death.Usually it is divided into SCHD and acute coronary syndrome in clinic.Coronary artery
Narrow or be the reason for obstruction：The long-term too high, cholesterol of blood fat in blood is deposited in coronary artery tube chamber with accumulating over a long period
Inner membrance on, formed ground pattern patch, the inner membrance of otherwise smooth is become coarse, soft tube wall becomes stiff, herein basis
On, the blood platelet of rupture also condenses adhesion and got on, and then just as river course is blocked by mud, coronary lumen is narrowed, even
Entirely shut.Coronary artery not smooth or even entirely shut, cause myocardial blood supply bad, cardiac muscle cannot get the nutrition of blood and necrosis claims
For myocardial infarction, this is the performance of coronary heart disease most serious.Once myocardium large area infarct, can not quickly eliminate again if, then
The life of people also just finishes.Modern medicine is broadly divided into two classes under the guidance of this theory, to cardiopathic treatment means：
First, include expansion blood vessel class medicine and the molten lipid drug of thrombolysis using medicine；Second, support, bypass surgery.In controlling for coronary heart disease
In treatment, intervention operation and bypass surgery belong to invasive treatment, while postoperative complication has a strong impact on the health of patient.
These methods are particularly effective it is significant to rescue the sexual stage in the treatment to cardiac.But not
The precipitation again that can solve the rubbish such as vascular lipids from source forms new patch, causes blood vessel restenosis, blocks, the heart
The problem of not smooth old disease of flesh blood supply recurs.
More with promoting blood circulation and removing blood stasis in the new Chinese medicine of the treatment coronary disease and angina pectoris listed in recent years, regulating qi-flowing for relieving pain therapy is
It is main, as Diaoxinxue Kang, Salvia Miltiorrhiza Oral Liquid, compound capsule of red sage root, XINTONGKOU PIAN, BUXINQI KOUFUYE, grow the heart-yin oral liquid,
Yiqi oral liquid etc., also have in addition to adjust the research based on renal function, such as the China of application number 201110155727.3
A kind of Chinese medicine for treating coronary heart disease disclosed in patent.It is by cultivated land, Fructus Corni, saline cistanche, gun additioner, ginseng, the tuber of dwarf lilyturf, osmanthus
The vegetable Chinese herbal medicines such as branch, Radix Angelicae Sinensis, the Radix Astragali, the red sage root, santal, Ligusticum wallichii, radix scrophulariae, the dried rhizome of rehmannia, hawthorn, honeysuckle flower, fructus amomi are made up of raw material.With
It is to nurse one's health renal function as the key link treated, while focus on the function of the internal organs such as kidney, the heart, liver, spleen in treatment coronary heart disease
Coordinate, kidney yin is grown, lower member obtain warm, qi and blood must be mended, extravasated blood must solve, heat toxin can be clear.But although coronary heart disease gradually tends to year
Lightization, but the main body of its infringement, still or with the weaker the elderly of cardiac function, Running water never becomes putrid, and pain is then obstructed, from numbness
For in terms of disease, it is the inducement of coronary heart attack that cardiac function is weak, so, present invention prescription in terms of cardiac function is strengthened obtains
The Chinese medicine composition of coronary heart disease must be treated.
The content of the invention
In view of this, the purpose of the present invention is in view of the shortcomings of the prior art, there is provided a kind of Chinese medicine group for treating coronary heart disease
Compound, reach preferable therapeutic effect effect.
To reach above-mentioned purpose, the present invention uses following technical scheme：
A kind of Chinese medicine composition for treating coronary heart disease, the composition and its parts by weight of its bulk drug are red sage root 100-150 parts,
Ripe pseudo-ginseng 100-150 parts, borneol 100-150 parts, hedgehog heart 100-150 parts, rhizome of chuanxiong 80-120 parts, Radix Astragali 80-120 parts, capsicum
Bar 80-120 parts, ginseng 60-80 parts, hairyvein agrimony 60-80 parts, lepidium seed 60-80 parts, cymbopogon distans 60-80 parts, Hericium erinaceus 60-80
Part, monkshood 40-60 parts, amber 40-60 parts, rhizoma nardostachyos 40-60 parts, hawthorn 40-60 parts, ginger 10-20 parts and radix glycyrrhizae 10-20 parts.
Further, the composition of its bulk drug and its parts by weight are red sage root 120-130 parts, ripe pseudo-ginseng 120-130 parts, ice
Piece 120-130 parts, hedgehog heart 120-130 parts, rhizome of chuanxiong 90-110 parts, Radix Astragali 90-110 parts, pepper bar 90-110 parts, ginseng 65-
75 parts, hairyvein agrimony 65-75 parts, lepidium seed 65-75 parts, cymbopogon distans 65-75 parts, Hericium erinaceus 65-75 parts, monkshood 45-55 parts, amber
45-55 parts, rhizoma nardostachyos 45-55 parts, hawthorn 45-55 parts, ginger 13-16 parts and radix glycyrrhizae 15-20 parts.
Further, the composition of its bulk drug and its parts by weight are 125 parts of the red sage root, ripe 125 parts of pseudo-ginseng, 125 parts of borneol,
130 parts of the hedgehog heart, 100 parts of rhizome of chuanxiong, 100 parts of the Radix Astragali, 100 parts of pepper bar, 70 parts of ginseng, 70 parts of hairyvein agrimony, 70 parts of lepidium seed, rue
18 parts of 70 parts of vanilla, 70 parts of Hericium erinaceus, 50 parts of monkshood, 50 parts of amber, 50 parts of rhizoma nardostachyos, 50 parts of hawthorn, 15 parts of ginger and radix glycyrrhizae.
A kind of Chinese medicine composition pill preparation method for treating coronary heart disease, comprises the following steps：
Step 1: the pepper bar is dried, crushed, added after boiling water in iron pan in iron pan, decoct 30-50 points
Clock；Water is separated with pepper bar powder filter while hot, powder filters out, clear liquid stand for standby use；The weight of boiling water and pepper bar ratio：5-
10:1；
Step 2: the hedgehog heart is taken out through vinegar from live body, crushed, puddled with honey, then bake and bank up with earth, be ground into powder i.e.
Can；The weight ratio of the honey and the hedgehog heart is 2-5:1；
Step 3: monkshood warm water is soaked 3-5 days, courage bar immersion 3-5 hours are taken out, are rinsed 1-3 times in the sink, then with
Vinegar soaks 30-50 minutes；Simmered and baked with hometown in oven；
Step 4: the monkshood that step 3 is treated, and the red sage root, borneol, rhizome of chuanxiong, the Radix Astragali, ginseng, hairyvein agrimony, Roripa montana
Son, cymbopogon distans, Hericium erinaceus, amber, rhizoma nardostachyos, hawthorn, ginger and radix glycyrrhizae crush to obtain fine powder, and clear liquid obtained by fine powder step 1 is soaked
Steep 30-50 minutes；Add the ethanol of 3-5 times of parts by weight, refluxing extraction 30-50 minutes, collect phegma, 2- is added again in fine powder
The ethanol of 3 times of parts by weight, refluxing extraction 20-30 minutes, phegma it will merge twice, concentration, dry medicinal extract, the ethanol
Volume fraction 60-75%；
Step 5: pseudo-ginseng is fried, is ground into fine powder；
Step 6: medicinal extract obtained by powder obtained by step 2, step 4 is mixed with the fine powder of step 5 Chinese medicine effectively into
Part, add auxiliary material and pill is made；The weight of the auxiliary material and effective components of Chinese medicinal ratio is 1-2：1.
The red sage root
Meridian distribution of property and flavor：Hardship, it is slightly cold.The thoughts of returning home, Liver Channel.
Effect：Blood menstruation regulating, stasis-dispelling and pain-killing, cool blood to disappear carbuncle, relieving restlessness that clears away heart-fire, nourishing blood and tranquilization.
Cure mainly：The red sage root can be promoting blood circulation and removing blood stasis, removes obstruction in channels to relieve pain, blood-nourishing calming heart, can increase coronary heart disease CBF, improves myocardial contraction
Power, without increasing myocardial anoxia amount, promote Doppler flow mapping and blood flow reallocation.
Borneol
Meridian distribution of property and flavor：It is pungent, bitter, it is slightly cold.The thoughts of returning home, spleen, lung channel.
Effect：Inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain.
Cure mainly：Coma, sore, abscess of throat, aphthae are closed for key.
Pseudo-ginseng
Meridian distribution of property and flavor：Sweet slight bitter, temperature.Enter liver, stomach, large intestine channel.
Effect, hemostasis, dissipate the stasis of blood, detumescence, analgesic therapy.
Cure mainly, control haematemesis, hemoptysis, bleeding from five sense organs or subcutaneous tissue, have blood in stool, bloody flux, uterine bleeding , Disorder lumps in the abdomen, postpartum anemic fainting, lochia not under, fall and flutter hemostasis,
Traumatism and bleeding, carbuncle swells pain.
The hedgehog heart, contain norepinephrine, adrenaline, and 4- (2- amino-ethyls)-pyrocatechol, catecholamine etc.
Can cardioactive incretion material.
Ligusticum wallichii
Meridian distribution of property and flavor：It is pungent, temperature.Return liver, courage, pericardium channel.
Effect：Blood-activating and qi-promoting, wind-expelling pain-stopping.For pacifying nerve, positive head wind headache, abdominal mass is suffered from abdominal pain, chest side of body shouting pain,
Tumbling and swelling, headache, arthralgia pain due to rheumatism.Ligusticum wallichii can expand smooth muscle, improve microcirculation, and have anti-freezing, resistant to aggregation effect, and pass through
Expand peripheral vessel and be depressured.
The Radix Astragali
Meridian distribution of property and flavor：Sweet, the tepor of property.Return lung, spleen, liver and kidney channel.
Effect：There are invigorating qi for consolidating superficies, arrest sweating admittedly take off, torr sore myogenic, inducing diuresis for removing edema.
Cure mainly：The Radix Astragali can strengthen myocardial contractive power, expand coronary artery, improve myocardial blood flow and myocardial metabolism, improve super oxygen
Thing is disproportionated enzyme activity, lowers lipid peroxide contents, damage caused by so as to mitigate free radical.
Pepper bar：With eliminating cold-damp, by cold numbness, scattered blood stasis stagnates.Control rheumatism crymodynia, the effect of pernio.
Ginseng
Meridian distribution of property and flavor：Sweet, slight bitter, put down.Returns spleen, lung, the heart channel of Hang-Shaoyin.
Effect：Reinforce vital energy, veins takes off admittedly, reinforce the spleen to benefit the lung, promote the production of body fluid, calm the nerves.
Cure mainly：To be taken off for physically weak, cold weak pulse of limb, spleen eating less loose stool, shortness of breath and fatigue, the deficiency syndrome of the lung is breathed with cough, and injury thirst is interior
Heat is quenched one's thirst, and prolonged illness void is thin, insomnia of palpitating with fear, impotence Gong Leng；Heart failure, cardiogenic shock.
Monkshood：
Meridian distribution of property and flavor：Acrid flavour, sweet, property heat are poisonous；Enter the heart, spleen, kidney channel.
Effect：Recuperating depleted yang, mends fire supporing yang, dispelling cold and removing dampness.
Cure mainly：Control yang depletion sweating, peripheral coldness, feeble and impalpable pulse；Deficiency-cold in spleen and stomach, trusted subordinate's crymodynia, vomiting, diarrhea, cold dysentery are small
Youngster shies slowly, deficiency of yang diseases caused by external factors；Control the insufficiency of the kidney yang, aversion to cold and cold limbs, impotence, frequent micturition, cold sensation of the genitalia oedema；Wind-cold-dampness arthralgia, cloudy subcutaneous ulcer, sore leakage.
Hairyvein agrimony
Nature and flavor：Hardship, it is puckery, put down.
Channel tropism：The thoughts of returning home, Liver Channel.
Effect：Astringing to arrest bleeding, preventing malaria, stop dysentery, removing toxic substances, qi-restoratives.
Cure mainly：For spitting blood, spit blood, metrostaxis, malaria, bloody flux, carbuncle sore tumefacting virus, under pruritus vulvae band, de-power internal lesion caused by overexertion.
Lepidium seed
Meridian distribution of property and flavor：It is bitter, pungent, Great Cold.Return lung, bladder warp.
Effect：Removing heat from lung and relieving asthma, inducing diuresis for removing edema.
Cure mainly：Stop up for phlegm and breath with cough, chest and abdomen ponding.Composition containing cardiac glycoside, it can shrink the cat heart and strengthen, decreased heart rate, and
The heart of exhaustion can be made increase output quantity, reduce vein pressure.
Cymbopogon distans
Meridian distribution of property and flavor：It is cool in nature, acrid flavour, hardship, enter bladder, lung channel.
Effect：Chinese medicine cymbopogon distans of relievining asthma have cold dispelling excreting dampness, relieving cough and asthma, during promoting the circulation of qi is wide.
Cure mainly：Anemofrigid cold, cough and asthma, arthralgia pain due to rheumatism, abdominal distension.
Hericium erinaceus
Meridian distribution of property and flavor：It is mild-natured, sweet, returns spleen, stomach, the heart channel of Hang-Shaoyin.
Effect：Promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite, tranquilize the mind and promote the intelligence.
Cure mainly：Having indigestion does not disappear, abdominal distention, spleen eating less, insomnia and dreamful sleep.
Rhizoma nardostachyos
Meridian distribution of property and flavor：It is acrid flavour, sweet, it is warm-natured；Returns spleen, stomach.
Effect：With warming spleen and stomach for dispelling cold, regulating qi-flowing for relieving pain, the effect of appetizing of being amusing.
Coldness and pain in the epigastrium turgor is cured mainly, do not feel like eating, pectoralgia, toothache, falls servant's pain of injury, beriberi edema, choleraic myospasm.
Amber
Meridian distribution of property and flavor：It is mild-natured, sweet to return：The heart, liver, bladder warp
Effect：Tranquillizing the mind by relieving convulsion, promoting blood circulation to remove blood stasis, inducing diuresis for treating strangurtia.
Cure mainly：Have no peace of mind, palpitation and insomnia, infantile convulsion epilepsy, blood-stasis syndrome, stranguria, the retention of urine.
Hawthorn,
Nature and flavor：It is slightly warm in nature, sour, sweet；Returns spleen, stomach, Liver Channel.
Effect：Appetite-stimulating indigestion-relieving, change stagnant disperse accumulations, promoting blood circulation to remove blood stasis, resolving sputum promoting the circulation of qi.
Cure mainly：For carnivorous stagnant product, a lump in the abdomen causing distension and pain, abdominal distension feeling of fullness, stasis blocking stomachache, phlegm and retained fluid, diarrhea, discharging fresh blood stool etc..Mountain
Short, bristly hair or beard can significantly reduce serum cholesterol and triglycerides, effectively prevent and treat atherosclerosis；Hawthorn can also be received by strengthening cardiac muscle
Contracting power, increase cardiac output, expansion of coronary artery, increase coronary blood flow, reduce myocardial oxygen consumption etc. play cardiac stimulant and
Prevent anginal effect.In addition, the general flavone in hawthorn plays the role of to expand blood vessel and lasting buck.
Ginger
Meridian distribution of property and flavor：Slightly warm in nature, acrid flavour；Return lung warp, the spleen channel, stomach.
Effect：Inducing diaphoresis cough-relieving, warming lung and reducing phlegm, removing toxic substances, wind dispelling cold dispelling.
Cure mainly：Vomiting, turgor, anemofrigid cold, cough ant phlegm, diarrhea.
Radix glycyrrhizae
Meridian distribution of property and flavor：Nature and flavor, it is sweet, it is mild-natured.Channel tropism, the thoughts of returning home, lung, spleen, stomach.
Effect, invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.
Cure mainly, for weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle swells sore
Poison, alleviate drug toxicity, strong.
Coronary heart disease be coronary atherosclerotic heart disease be coronary artery occur atherosclerotic lesion and
Cause lumen of vessels stenosis or occlusion, cause heart disease caused by myocardial ischemia, anoxic or necrosis, its group trend of falling ill is in the heart
The elderly of function phase to weakness.So inventor thinks that it is key to treat coronary heart disease cardiac stimulant, but conventional cardiotonic drug one
Aspect can have toxic side effect, and on the other hand, then it is too quickly to have a medication, is only suitable only for first aid or seriously ill patient takes,
Curative effect is not good enough in terms of the treatment that clinical treatment and cardiac function recover.
The beneficial effects of the invention are as follows：
The formula of the present invention is used as medicine with the compatibility mechanism prescription of science, is obtained by the theoretical guidance of clear and definite monarch
The effect of preferable.
With stasis-dispelling and pain-killing, cool blood to disappear carbuncle, relieving restlessness that clears away heart-fire, the nourishing blood and tranquilization red sage root, with hemostasis, the stasis of blood is dissipated, is subsided a swelling, the three of analgesic therapy
7th, inducing resuscitation of having one's ideas straightened out, the borneol of clearing away heat to and alleviating pain, norepinephrine, adrenaline, and 4- (2- amino-ethyls)-burnt catechu are contained
Phenol, catecholamine etc. can cardioactive incretion material hedgehog heart monarch drug in a prescription, the effect of playing cardiac stimulant, nourishing heart, metancenter altogether.
With blood-activating and qi-promoting, the rhizome of chuanxiong of wind-expelling pain-stopping, the effect of invigorating qi for consolidating superficies, arrest sweating admittedly take off, torr sore myogenic, inducing diuresis for removing edema
The Radix Astragali, eliminating cold-damp, by cold numbness, scattered blood stasis stagnates, controls rheumatism crymodynia pepper bar, with astringing to arrest bleeding, detoxifies, the hairyvein agrimony of qi-restoratives,
There is increase cardiac energy to slow down heartbeat effect simultaneously for removing heat from lung and relieving asthma, the lepidium seed of inducing diuresis for removing edema, and with cold dispelling excreting dampness, cough-relieving is put down
Asthma, the cymbopogon distans ministerial drug during promoting the circulation of qi is wide.To reinforce vital energy, veins takes off admittedly, reinforce the spleen to benefit the lung, promote the production of body fluid, ginseng, the Hui Yang to calm the nerves is rescued
It is inverse, mends fire supporing yang, the monkshood of dispelling cold and removing dampness, promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite, the Hericium erinaceus of tranquilize the mind and promote the intelligence, tranquillizing the mind by relieving convulsion, Huoxue San "
The amber of the stasis of blood, there is warming spleen and stomach for dispelling cold, regulating qi-flowing for relieving pain, the rhizoma nardostachyos and appetite-stimulating indigestion-relieving of appetizing of being amusing, change stagnant disperse accumulations, promoting blood circulation to remove blood stasis, change
The hawthorn adjutant of phlegm promoting the circulation of qi.It is warming lung and reducing phlegm with inducing diaphoresis cough-relieving, removing toxic substances, the ginger of wind dispelling cold dispelling and invigorate the spleen and benefit qi, it is clearing heat and detoxicating,
Expelling phlegm and arresting coughing, relieving spasm to stop pain, the radix glycyrrhizae of coordinating the drug actions of a prescription make medicine.
Cardiac stimulant is basic in the prescription of the present invention, and nourishing heart shield heart is crucial, is aided with promoting blood circulation, sensible blood vessels.The monarch and his subjects help
Make to act on each other, complement each other.Inducing resuscitation of having one's ideas straightened out, the common enhancing of borneol and the hedgehog heart of clearing away heat to and alleviating pain and accessory heart function, with
Calm the nerves nourishing heart the red sage root and hemostasis, dissipate the stasis of blood, detumescence, the common nourishing heart of pseudo-ginseng of analgesic therapy, cardiac stimulant.With rhizome of chuanxiong cardiac stimulus vigor, lure
The function for the stress reaction auxiliary monarch drug in a prescription cardiac stimulant for making up one's mind dirty, with the sensible blood vessel of pepper bar, the effect of gain we's promoting blood circulation；Roripa
There is Li increase cardiac energy to slow down heartbeat effect cymbopogon distans simultaneously cold dispelling excreting dampness, relieving cough and asthma, the gain during promoting the circulation of qi is wide
The function of monarch drug in a prescription cardiac stimulant nourishing heart.Ginseng qi-tonifying, monkshood are supporing yang, dehumidify, cold dispelling, Hericium erinaceus tranquilize the mind and promote the intelligence, and amber promoting blood circulation to remove blood stasis is living
Blood dissipates the stasis of blood, the hawthorn of resolving sputum promoting the circulation of qi, the promoting flow of qi and blood circulation, tranquilizing and allaying excitement, increases the deficiency that monarch drug in a prescription dissipates the stasis of blood, the effect of its soft cardiac stimulant, makes
Drug effect is long and does not hinder at all, and cardiac stimulant does not hinder cardiac function, and dissolving stasis is without hindering just.Ginger and radix glycyrrhizae reconcile by medicine, priming channel tropism,
Each medicine plays curative effect altogether.
Embodiment
Embodiment 1
A kind of Chinese medicine composition for treating coronary heart disease, the composition and its parts by weight of its bulk drug are 100 parts of the red sage root, ripe three
7 100 parts, 100 parts of borneol, 100 parts of the hedgehog heart, 80 parts of rhizome of chuanxiong, 80 parts of the Radix Astragali, 80 parts of pepper bar, 60 parts of ginseng, hairyvein agrimony 60
Part, 60 parts of lepidium seed, 60 parts of cymbopogon distans, 60 parts of Hericium erinaceus, 40 parts of monkshood, 40 parts of amber, 40 parts of rhizoma nardostachyos, 40 parts of hawthorn, ginger
10 parts and 10 parts of radix glycyrrhizae.
A kind of Chinese medicine composition pill preparation method for treating coronary heart disease, comprises the following steps：
Step 1: the pepper bar is dried, crushed, add in iron pan, decoct 30 minutes after boiling water in iron pan；Take advantage of
Heat separates water with pepper bar powder filter, and powder filters out, clear liquid stand for standby use；The weight of boiling water and pepper bar ratio：5:1；
Step 2: the hedgehog heart is taken out through vinegar from live body, crushed, puddled with honey, then bake and bank up with earth, be ground into powder i.e.
Can；The weight ratio of the honey and the hedgehog heart is 2:1；
Step 3: monkshood warm water is soaked 3 days, take out courage bar and soak 3 hours, rinse 1 time in the sink, then soaked with vinegar
30 minutes；Simmered and baked with hometown in oven；
Step 4: the monkshood that step 3 is treated, and the red sage root, borneol, rhizome of chuanxiong, the Radix Astragali, ginseng, hairyvein agrimony, Roripa montana
Son, cymbopogon distans, Hericium erinaceus, amber, rhizoma nardostachyos, hawthorn, ginger and radix glycyrrhizae crush to obtain fine powder, and clear liquid obtained by fine powder step 1 is soaked
Bubble 30 minutes；Add the ethanol of 3 times of parts by weight, refluxing extraction 30 minutes, collect phegma, 2 times of parts by weight are added again in fine powder
Ethanol, refluxing extraction 20 minutes, phegma will merge twice, concentration, dry medicinal extract, the volume fraction of the ethanol
60%；
Step 5: pseudo-ginseng is fried, is ground into fine powder；
Step 6: medicinal extract obtained by powder obtained by step 2, step 4 is mixed with the fine powder of step 5 Chinese medicine effectively into
Part, add auxiliary material and pill is made；The weight of the auxiliary material and effective components of Chinese medicinal ratio is 1：1.
Embodiment 2
A kind of Chinese medicine composition for treating coronary heart disease, the composition and its parts by weight of its bulk drug are 150 parts of the red sage root, ripe three
7 150 parts, 150 parts of borneol, 150 parts of the hedgehog heart, 120 parts of rhizome of chuanxiong, 120 parts of the Radix Astragali, 120 parts of pepper bar, 80 parts of ginseng, hairyvein agrimony
80 parts, 80 parts of lepidium seed, 80 parts of cymbopogon distans, 80 parts of Hericium erinaceus, 60 parts of monkshood, 60 parts of amber, 60 parts of rhizoma nardostachyos, 60 parts of hawthorn, life
20 parts of 20 parts of ginger and radix glycyrrhizae.
A kind of Chinese medicine composition pill preparation method for treating coronary heart disease, comprises the following steps：
Step 1: the pepper bar is dried, crushed, add in iron pan, decoct 50 minutes after boiling water in iron pan；Take advantage of
Heat separates water with pepper bar powder filter, and powder filters out, clear liquid stand for standby use；The weight of boiling water and pepper bar ratio：10:1；
Step 2: the hedgehog heart is taken out through vinegar from live body, crushed, puddled with honey, then bake and bank up with earth, be ground into powder i.e.
Can；The weight ratio of the honey and the hedgehog heart is 5:1；
Step 3: monkshood warm water is soaked 5 days, take out courage bar and soak 5 hours, rinse 1-3 times in the sink, then soaked with vinegar
Bubble 50 minutes；Simmered and baked with hometown in oven；
Step 4: the monkshood that step 3 is treated, and the red sage root, borneol, rhizome of chuanxiong, the Radix Astragali, ginseng, hairyvein agrimony, Roripa montana
Son, cymbopogon distans, Hericium erinaceus, amber, rhizoma nardostachyos, hawthorn, ginger and radix glycyrrhizae crush to obtain fine powder, and clear liquid obtained by fine powder step 1 is soaked
Bubble 50 minutes；Add the ethanol of 5 times of parts by weight, refluxing extraction 50 minutes, collect phegma, 3 times of parts by weight are added again in fine powder
Ethanol, refluxing extraction 30 minutes, phegma will merge twice, concentration, dry medicinal extract, the volume fraction of the ethanol-
75%；
Step 5: pseudo-ginseng is fried, is ground into fine powder；
Step 6: medicinal extract obtained by powder obtained by step 2, step 4 is mixed with the fine powder of step 5 Chinese medicine effectively into
Part, add auxiliary material and pill is made；The weight of the auxiliary material and effective components of Chinese medicinal ratio is 2：1.
Embodiment 3
A kind of Chinese medicine composition for treating coronary heart disease, the composition and its parts by weight of its bulk drug are 125 parts of the red sage root, ripe three
7 125 parts, 125 parts of borneol, 130 parts of the hedgehog heart, 100 parts of rhizome of chuanxiong, 100 parts of the Radix Astragali, 100 parts of pepper bar, 70 parts of ginseng, hairyvein agrimony
70 parts, 70 parts of lepidium seed, 70 parts of cymbopogon distans, 70 parts of Hericium erinaceus, 50 parts of monkshood, 50 parts of amber, 50 parts of rhizoma nardostachyos, 50 parts of hawthorn, life
18 parts of 15 parts of ginger and radix glycyrrhizae.
A kind of Chinese medicine composition pill preparation method for treating coronary heart disease, comprises the following steps：
Step 1: the pepper bar is dried, crushed, add in iron pan, decoct 40 minutes after boiling water in iron pan；Take advantage of
Heat separates water with pepper bar powder filter, and powder filters out, clear liquid stand for standby use；The weight of boiling water and pepper bar ratio：7:1；
Step 2: the hedgehog heart is taken out through vinegar from live body, crushed, puddled with honey, then bake and bank up with earth, be ground into powder i.e.
Can；The weight ratio of the honey and the hedgehog heart is 3:1；
Step 3: monkshood warm water is soaked 4 days, take out courage bar and soak 4 hours, rinse 2 times in the sink, then soaked with vinegar
40 minutes；Simmered and baked with hometown in oven；
Step 4: the monkshood that step 3 is treated, and the red sage root, borneol, rhizome of chuanxiong, the Radix Astragali, ginseng, hairyvein agrimony, Roripa montana
Son, cymbopogon distans, Hericium erinaceus, amber, rhizoma nardostachyos, hawthorn, ginger and radix glycyrrhizae crush to obtain fine powder, and clear liquid obtained by fine powder step 1 is soaked
Bubble 40 minutes；Add the ethanol of 4 times of parts by weight, refluxing extraction 40 minutes, collect phegma, 2.5 times of weight are added again in fine powder
Part ethanol, refluxing extraction 20-30 minutes, phegma will merge twice, concentration, dry medicinal extract, the volume integral of the ethanol
Number 70%；
Step 5: pseudo-ginseng is fried, is ground into fine powder；
Step 6: medicinal extract obtained by powder obtained by step 2, step 4 is mixed with the fine powder of step 5 Chinese medicine effectively into
Part, add auxiliary material and pill is made；The weight of the auxiliary material and effective components of Chinese medicinal ratio is 1.5：1.
Embodiment 4
A kind of Chinese medicine composition for treating coronary heart disease, the composition and its parts by weight of its bulk drug are 120 parts of the red sage root, ripe three
7 120 parts, 120 parts of borneol, 120 parts of the hedgehog heart, 90 parts of rhizome of chuanxiong, 90 parts of the Radix Astragali, 90 parts of pepper bar, 65 parts of ginseng, hairyvein agrimony 65
Part, 65 parts of lepidium seed, 65 parts of cymbopogon distans, Hericium erinaceus 65- parts, 45 parts of monkshood, 45 parts of amber, 45 parts of rhizoma nardostachyos, 45 parts of hawthorn, ginger
13 parts and 15 parts of radix glycyrrhizae.
Its preparation method is shown in embodiment 3.
Embodiment 5
A kind of Chinese medicine composition for treating coronary heart disease, the composition and its parts by weight of its bulk drug are 130 parts of the red sage root, ripe three
7 130 parts, 130 parts of borneol, 130 parts of the hedgehog heart, 110 parts of rhizome of chuanxiong, 110 parts of the Radix Astragali, 110 parts of pepper bar, 75 parts of ginseng, hairyvein agrimony
75 parts, 75 parts of lepidium seed, 75 parts of cymbopogon distans, 75 parts of Hericium erinaceus, 55 parts of monkshood, 55 parts of amber, 55 parts of rhizoma nardostachyos, 55 parts of hawthorn, life
20 parts of 16 parts of ginger and radix glycyrrhizae.
Its preparation method is shown in embodiment 3.
Embodiment 6
A kind of Chinese medicine composition for treating coronary heart disease, the composition and its parts by weight of its bulk drug are 100 parts of the red sage root, ripe three
7 150 parts, 120 parts of borneol, 130 parts of the hedgehog heart, 100 parts of rhizome of chuanxiong, 80 parts of the Radix Astragali, 80 parts of pepper bar, 60 parts of ginseng, hairyvein agrimony 80
Part, 60 parts of lepidium seed, 80 parts of cymbopogon distans, 60 parts of Hericium erinaceus, 50 parts of monkshood, 40 parts of amber, 40 parts of rhizoma nardostachyos, 50 parts of hawthorn, ginger
15 parts and 10 parts of radix glycyrrhizae.
Its preparation method is shown in embodiment 3.
Embodiment 7
A kind of Chinese medicine composition for treating coronary heart disease, the composition and its parts by weight of its bulk drug are 120 parts of the red sage root, ripe three
7 122 parts, 128 parts of borneol, 124 parts of the hedgehog heart, 95 parts of rhizome of chuanxiong, 95 parts of the Radix Astragali, 98 parts of pepper bar, 68 parts of ginseng, hairyvein agrimony 70
Part, 72 parts of lepidium seed, 75 parts of cymbopogon distans, 66 parts of Hericium erinaceus, 48 parts of monkshood, 50 parts of amber, 52 parts of rhizoma nardostachyos, 53 parts of hawthorn, ginger
14 parts and 16 parts of radix glycyrrhizae.
Its preparation method is shown in embodiment 3.
Embodiment 8
A kind of Chinese medicine composition for treating coronary heart disease, the composition and its parts by weight of its bulk drug are 108 parts of the red sage root, ripe three
7 110 parts, 110 parts of borneol, 140 parts of the hedgehog heart, 115 parts of rhizome of chuanxiong, 118 parts of the Radix Astragali, 113 parts of pepper bar, 68 parts of ginseng, hairyvein agrimony
72 parts, 78 parts of lepidium seed, 63 parts of cymbopogon distans, 78 parts of Hericium erinaceus, 52 parts of monkshood, 43 parts of amber, rhizoma nardostachyos 40-60 parts, 58 parts of hawthorn,
20 parts of 19 parts of ginger and radix glycyrrhizae.
Its preparation method is shown in embodiment 3.
Comparative example 1
Comparative example 1 is substantially the same manner as Example 3, and its difference is, removes the Chinese medicine hedgehog heart.
Comparative example 2
Comparative example 2 is substantially the same manner as Example 3, and its difference is, adds the Radix Angelicae Sinensis of 60-80 part weight.
Comparative example 3
The formula of the Chinese patent of Application No. 201110155727.3, which decocts, to be used as medicine.
Clinical test
1. case counts
Statistics comes the here person of seing patients over the years, wherein remaining with 1400 people of complete case history archive record, wherein male
900 people, the people of women 500.Age is in the 40-55 year people of person 200, the 56-65 year people of person 700, more than the 66 years old people of person 500.1400 should
In the person of examining, the most short person of the course of disease more than 100 days, most elder was up to 20 years.To the pill of the person's of seing patients oral Chinese medicine composition, three times a day,
Each 5-10 grains/3-6g.One month is a course for the treatment of, and general one course for the treatment of subjective symptoms of patient is obviously improved, Most patients three
Reach healing or effective to four courses for the treatment of.The pretherapy and post-treatment clinical manifestation of patient is observed and recorded during medication in detail, is such as found not
Good reaction, takes respective handling.Other drugs stop without exception during observation.
2. diagnostic criteria
According to State Administration of Traditional Chinese Medicine's issue on June 28th, 1994《Chinese medical disease Standardization of diagnosis and curative effect》Carry out disease
Diagnosis and the judgement of criterion of therapeutical effect.
Clinical curative effect analysis is shown in Table 1, and the overall clinical efficacy rate of the embodiment of the present invention 3 is up to 100% as seen from the table, embodiment 1,
Embodiment 5, embodiment 7 are respectively 99%, 99.5% and 99.5%, and do not find that this medicament has significantly during treatment
Toxic side effect.Comparative example 1-3 total effective rate is followed successively by 84%, 85% and 86%.The clinical effectiveness of the present invention is significantly better than pair
The clinical effectiveness of ratio.
The TCM Syndrome Type of table 1 and clinical curative effect analysis
Finally illustrate, the above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted, this area is common
Other modifications or equivalent substitution that technical staff is made to technical scheme, without departing from technical solution of the present invention
Spirit and scope, all should cover among scope of the presently claimed invention.
Claims (4)
1. a kind of Chinese medicine composition for treating coronary heart disease, it is characterised in that the composition and its parts by weight of its bulk drug are the red sage root
100-150 parts, ripe pseudo-ginseng 100-150 parts, borneol 100-150 parts, hedgehog heart 100-150 parts, rhizome of chuanxiong 80-120 parts, Radix Astragali 80-
120 parts, pepper bar 80-120 parts, ginseng 60-80 parts, hairyvein agrimony 60-80 parts, lepidium seed 60-80 parts, cymbopogon distans 60-80 parts, monkey
Head mushroom 60-80 parts, monkshood 40-60 parts, amber 40-60 parts, rhizoma nardostachyos 40-60 parts, hawthorn 40-60 parts, ginger 10-20 parts and radix glycyrrhizae
10-20 parts.
A kind of 2. Chinese medicine composition for treating coronary heart disease according to claim 1, it is characterised in that the composition of its bulk drug
And its parts by weight are, red sage root 120-130 parts, ripe pseudo-ginseng 120-130 parts, borneol 120-130 parts, hedgehog heart 120-130 parts, rhizome of chuanxiong
90-110 parts, Radix Astragali 90-110 parts, pepper bar 90-110 parts, ginseng 65-75 parts, hairyvein agrimony 65-75 parts, lepidium seed 65-75 parts,
Cymbopogon distans 65-75 parts, Hericium erinaceus 65-75 parts, monkshood 45-55 parts, amber 45-55 parts, rhizoma nardostachyos 45-55 parts, hawthorn 45-55 parts,
Ginger 13-16 parts and radix glycyrrhizae 15-20 parts.
A kind of 3. Chinese medicine composition for treating coronary heart disease according to claim 1, it is characterised in that the composition of its bulk drug
And its parts by weight are, 125 parts of the red sage root, ripe 125 parts of pseudo-ginseng, 125 parts of borneol, 130 parts of the hedgehog heart, 100 parts of rhizome of chuanxiong, 100 parts of the Radix Astragali,
100 parts of pepper bar, 70 parts of ginseng, 70 parts of hairyvein agrimony, 70 parts of lepidium seed, 70 parts of cymbopogon distans, 70 parts of Hericium erinaceus, 50 parts of monkshood, amber
18 parts of 50 parts of amber, 50 parts of rhizoma nardostachyos, 50 parts of hawthorn, 15 parts of ginger and radix glycyrrhizae.
4. a kind of Chinese medicine composition pill preparation method for the treatment of coronary heart disease according to claim any one of 1-3, it is special
Sign is, comprises the following steps：
Step 1: the pepper bar is dried, crushed, added after boiling water in iron pan in iron pan, decoct 30-50 minutes；Take advantage of
Heat separates water with pepper bar powder filter, and powder filters out, clear liquid stand for standby use；The weight of boiling water and pepper bar ratio：5-10:1；
Step 2: the hedgehog heart is taken out through vinegar from live body, crushed, puddled with honey, then bake and bank up with earth, be ground into powder；
The weight ratio of the honey and the hedgehog heart is 2-5:1；
Step 3: monkshood warm water is soaked 3-5 days, courage bar immersion 3-5 hours are taken out, are rinsed 1-3 times in the sink, then soaked with vinegar
Steep 30-50 minutes；Simmered and baked with hometown in oven；
Step 4: the monkshood that step 3 is treated, and the red sage root, borneol, rhizome of chuanxiong, the Radix Astragali, ginseng, hairyvein agrimony, lepidium seed, rue
Vanilla, Hericium erinaceus, amber, rhizoma nardostachyos, hawthorn, ginger and radix glycyrrhizae crush to obtain fine powder, and clear liquid obtained by fine powder step 1 is soaked into 30-
50 minutes；Add the ethanol of 3-5 times of parts by weight, refluxing extraction 30-50 minutes, collect phegma, adding 2-3 times again in fine powder weighs
The ethanol of part is measured, refluxing extraction 20-30 minutes, phegma will be merged twice, concentration, dry medicinal extract, the volume of the ethanol
Fraction 60-75%；
Step 5: pseudo-ginseng is fried, is ground into fine powder；
Step 6: powder, step 4 gained medicinal extract obtained by step 2 are mixed to obtain into effective components of Chinese medicinal with the fine powder of step 5, add
Enter auxiliary material and pill is made；The weight of the auxiliary material and effective components of Chinese medicinal ratio is 1-2：1.
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| US20050118290A1 (en) * | 2003-12-02 | 2005-06-02 | University Of Singapore | Compositions and method for treatment of steroid/nuclear receptor-mediated diseases |
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| US20050118290A1 (en) * | 2003-12-02 | 2005-06-02 | University Of Singapore | Compositions and method for treatment of steroid/nuclear receptor-mediated diseases |
| CN101181518A (en) * | 2007-07-12 | 2008-05-21 | 陈道卿 | Baoxin pill for curing coronary disease |
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Application publication date: 20180119 |