CN107593706B - Antibacterial liquid medicine for venous indwelling needle and preparation method thereof - Google Patents
Antibacterial liquid medicine for venous indwelling needle and preparation method thereof Download PDFInfo
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- CN107593706B CN107593706B CN201710649788.2A CN201710649788A CN107593706B CN 107593706 B CN107593706 B CN 107593706B CN 201710649788 A CN201710649788 A CN 201710649788A CN 107593706 B CN107593706 B CN 107593706B
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Abstract
The invention discloses an antibacterial liquid medicine for a venous indwelling needle, which comprises the following components in parts by weight: 87.99 parts of methanol with the concentration of 85 percent, 0.5 part of sodium citrate, 0.5 part of antioxidant, 1 part of permeation enhancer, 5.5 parts of minocycline hydrochloride, 4.5 parts of ciprofloxacin and 0.01 part of sodium dodecyl sulfate. The invention utilizes the synergistic effect of two drugs of minocycline hydrochloride and ciprofloxacin, and tests show that the optimal antibacterial ratio can effectively inhibit various bacteria, in particular to drug-resistant staphylococcus aureus. The penetration enhancer can enable the medicine to penetrate deeply in the indwelling needle catheter, and is different from the problems that the medicine is only remained on the surface layer when the medicine catheter is coated, so that the penetration depth is insufficient, the content is insufficient, and the antibacterial effect is not good enough. The antioxidant of the invention effectively prevents the oxidation of the antibacterial liquid medicine, and prolongs the effective duration of the antibacterial performance.
Description
Technical Field
The invention relates to the field of medicines, in particular to an antibacterial liquid medicine of an indwelling needle.
Background
The venous indwelling needle is a medical apparatus for venous indwelling transfusion, and is mainly applied to clinical venipuncture for medicine and nutrition supply of a patient. The traditional antibacterial venous indwelling needle is prepared by mixing an antibacterial medicament and a plastic master batch and then extruding, and the antibacterial medicament is damaged to a certain extent by high temperature in the extrusion process, so that the antibacterial effect of the traditional antibacterial venous indwelling needle is greatly reduced; some anti-infective agents containing silver ions are adopted, and the anti-infective agent containing the silver ions has the problem of patient allergy in clinic; some medicines without silver ions or other antibacterial components are adopted for coating processing, but the problems that the antibacterial medicine is oxidized after a long time and the antibacterial medicine permeates into the interior of the tube body are solved, so that the problems that the antibacterial performance is not good enough, the antibacterial performance can not be exerted for a long time, the antibacterial performance can not be sustained and the like are caused. The inner wall of a tube body of the existing venous indwelling needle is soaked in antibacterial liquid medicine and then dried to form an antibacterial layer, however, the antibacterial liquid medicine has poor penetration effect, meanwhile, the antibacterial drug has poor inhibition capability on drug-resistant staphylococcus aureus and other fungi, and is easy to oxidize, so that the venous indwelling needle has strong antibacterial capability compared with the traditional venous indwelling needle, and still has a larger improvement space.
Disclosure of Invention
The present invention aims to provide an antibacterial agent for a venous indwelling needle, a method for producing the antibacterial agent, and an indwelling needle containing the antibacterial agent, which are directed to the above-mentioned disadvantages of poor permeability and antibacterial property, and easy oxidation of the antibacterial agent in the venous indwelling needle in the prior art.
The technical scheme adopted by the invention is as follows: an antibacterial liquid medicine for a venous indwelling needle comprises the following components in parts by weight: 87.99 parts of methanol with the concentration of 85 percent, 0.5 part of sodium citrate, 0.5 part of antioxidant, 1 part of permeation enhancer, 5.5 parts of minocycline hydrochloride, 4.5 parts of ciprofloxacin and 0.01 part of sodium dodecyl sulfate.
The minocycline hydrochloride is a novel high-efficiency, quick-acting and long-acting semi-synthetic tetracycline preparation, has the strongest antibacterial action in the genus, has an antibacterial spectrum similar to that of doxycycline, shows excellent resistance to drug-resistant staphylococcus aureus, and is mostly used alone as a broad-spectrum antibiotic. Ciprofloxacin belongs to fluoroquinolones, and the antibacterial spectrum of ciprofloxacin is the same as that of norfloxacin, and the antibacterial activity of ciprofloxacin is the strongest fluoroquinolone widely used at present. The invention compounds the two medicines with strong antibacterial property, which not only does not cause mutual conflict of drug effects, but also ensures that the drug effects of the two medicines supplement each other due to the limitation of the compounding ratio, thereby further improving the antibacterial property to various fungi.
As a further improvement of the scheme, the antioxidant is sodium ascorbate, and the antioxidant has good stability after being mixed with other raw material components, so that the antioxidant property is further improved.
As a further improvement of the scheme, the penetration enhancer is butyl acetate which has good stability after being mixed with other raw material components, and is beneficial to further improving the penetration performance of the antibacterial drug on the tube body of the venous indwelling needle.
The preparation method of the antibacterial liquid medicine for the venous indwelling needle comprises the following steps: dissolving 85% methanol, sodium citrate and an antioxidant at 30-50 ℃ for 10-30 min according to the weight parts of the raw materials, adding a penetration enhancer, continuously dissolving for 10-20 min, then adding minocycline hydrochloride and ciprofloxacin, stirring for 15-30 min, finally adding sodium dodecyl sulfate, and stirring for 10-15 min to obtain a finished product.
The invention also provides a venous indwelling needle which comprises a tube body, wherein the inner wall of the tube body is attached with an antibacterial layer, and the antibacterial layer is formed by soaking and drying the antibacterial liquid medicine.
The specific treatment method of the catheter body in the venous indwelling needle comprises the following steps:
1) placing the tube body in ethanol, ultrasonically cleaning for 10min, ultrasonically cleaning in pure water for 15min, taking out, and drying for later use;
2) according to the weight parts of the raw materials, 87.99 parts of methanol with the concentration of 85%, 0.5 part of sodium citrate and 0.5 part of antioxidant are dissolved at the temperature of 30-50 ℃ for 10-30 min, the pipe body obtained in the step 1) is added, 1 part of permeation enhancer is added, the minocycline hydrochloride and 4.5 parts of ciprofloxacin are added after the dissolution is continued for 10-20 min, the stirring is carried out for 15-30 min, 0.01 part of sodium dodecyl sulfate is added, the stirring is carried out for 10-15 min, and then the pipe body is continuously soaked for 50-80 min;
3) and taking out the tube body, placing the tube body in an oven at 40-45 ℃ for drying for 8-12 h, washing for 3-5 times by using ionized water, drying the tube body by using an air gun, and then placing the tube body in the oven at 40-45 ℃ for drying for 4h to obtain the tube body with the antibacterial layer attached to the inner wall.
The invention has the beneficial effects that:
the invention utilizes the synergistic effect of two drugs of minocycline hydrochloride and ciprofloxacin, and tests show that the optimal antibacterial ratio can effectively inhibit various bacteria, in particular to drug-resistant staphylococcus aureus. The penetration enhancer can enable the medicine to penetrate deeply in the indwelling needle catheter, and is different from the problems that the medicine is only remained on the surface layer when the medicine catheter is coated, so that the penetration depth is insufficient, the content is insufficient, and the antibacterial effect is not good enough. The antioxidant of the invention effectively prevents the oxidation of the antibacterial liquid medicine, and prolongs the effective duration of the antibacterial performance.
The preparation method is simple, and the prepared finished product has good stability and is suitable for large-scale industrial production.
Detailed Description
The present invention is specifically described below with reference to examples in order to facilitate understanding of the present invention by those skilled in the art. It should be particularly noted that the examples are given solely for the purpose of illustration and are not to be construed as limitations on the scope of the invention, as non-essential improvements and modifications to the invention may occur to those skilled in the art, which fall within the scope of the invention as defined by the appended claims. Meanwhile, the raw materials mentioned below are not specified in detail and are all commercial products; the process steps or preparation methods not mentioned in detail are all process steps or preparation methods known to the person skilled in the art.
Example 1
An antibacterial liquid medicine for a venous indwelling needle comprises the following components in parts by weight: 87.99 parts of methanol with the concentration of 85 percent, 0.5 part of sodium citrate, 0.5 part of sodium ascorbate, 1 part of butyl acetate, 5.5 parts of minocycline hydrochloride, 4.5 parts of ciprofloxacin and 0.01 part of sodium dodecyl sulfonate. Wherein the weight ratio of minocycline hydrochloride is as follows: ciprofloxacin 1.22: 1.
The tube body in the vein indwelling needle is treated by adopting the antibacterial liquid medicine:
1) placing the tube body in ethanol, ultrasonically cleaning for 10min, ultrasonically cleaning in pure water for 15min, taking out, and drying for later use;
2) according to the weight parts of the raw materials, 87.99 parts of methanol with the concentration of 85%, 0.5 part of sodium citrate and 0.5 part of sodium ascorbate are dissolved at the temperature of 30-50 ℃ for 10-30 min, added into the tube body obtained in the step 1), 1 part of butyl acetate is added, the solution is continuously dissolved for 10-20 min, then 5.5 parts of minocycline hydrochloride and 4.5 parts of ciprofloxacin are added, the mixture is stirred for 15-30 min, 0.01 part of sodium dodecyl sulfate is added, the mixture is stirred for 10-15 min, and then the tube body is continuously soaked for 50-80 min;
3) and taking out the tube body, placing the tube body in an oven at the temperature of 40-45 ℃ for drying for 8-12 h, washing the tube body for 3-5 times by using ionized water, drying the tube body by using an air gun, and then placing the tube body in the oven at the temperature of 40-45 ℃ for drying for 4h to obtain the vein indwelling needle tube body in the embodiment 1.
Comparative example 1
An antibacterial liquid medicine for a venous indwelling needle comprises the following components in parts by weight: 87.99 parts of methanol with the concentration of 85 percent, 0.5 part of sodium citrate, 0.5 part of sodium ascorbate, 1 part of butyl acetate, 5 parts of minocycline hydrochloride, 10 parts of ciprofloxacin and 0.01 part of sodium dodecyl sulfonate. Wherein the weight ratio of minocycline hydrochloride is as follows: ciprofloxacin ═ 1: 2.
The tube body of the vein indwelling needle is treated by the antibacterial liquid medicine, the treatment method is the same as that of the embodiment 1, and the tube body of the vein indwelling needle of the comparative example 1 is obtained.
Comparative example 2
An antibacterial liquid medicine for a venous indwelling needle comprises the following components in parts by weight: 87.99 parts of methanol with the concentration of 85 percent, 0.5 part of sodium citrate, 0.5 part of sodium ascorbate, 1 part of butyl acetate, 5.5 parts of minocycline hydrochloride, 8.25 parts of ciprofloxacin and 0.01 part of sodium dodecyl sulfonate. Wherein the weight ratio of minocycline hydrochloride is as follows: ciprofloxacin is 1: 1.5.
The tube body of the vein indwelling needle is treated by the antibacterial liquid medicine, the treatment method is the same as that of the embodiment 1, and the tube body of the vein indwelling needle of the comparative example 2 is obtained.
Comparative example 3
An antibacterial liquid medicine for a venous indwelling needle comprises the following components in parts by weight: 87.99 parts of methanol with the concentration of 85 percent, 0.5 part of sodium citrate, 0.5 part of sodium ascorbate, 1 part of butyl acetate, 5.5 parts of minocycline hydrochloride, 4.5 parts of ciprofloxacin and 0.01 part of sodium dodecyl sulfonate. Wherein the weight ratio of minocycline hydrochloride is as follows: ciprofloxacin is 1:1.
The tube body of the vein indwelling needle is treated by the antibacterial liquid medicine, the treatment method is the same as that of the embodiment 1, and the tube body of the vein indwelling needle of the comparative example 3 is obtained.
Comparative example 4
An antibacterial liquid medicine for a venous indwelling needle comprises the following components in parts by weight: 87.99 parts of methanol with the concentration of 85 percent, 0.5 part of sodium citrate, 0.5 part of sodium ascorbate, 1 part of butyl acetate, 6 parts of minocycline hydrochloride, 4 parts of ciprofloxacin and 0.01 part of sodium dodecyl sulfonate. Wherein the weight ratio of minocycline hydrochloride is as follows: ciprofloxacin 1.5: 1.
The tube body of the vein indwelling needle is treated by the antibacterial liquid medicine, the treatment method is the same as that of the embodiment 1, and the tube body of the vein indwelling needle of the comparative example 4 is obtained.
Comparative example 5
An antibacterial liquid medicine for a venous indwelling needle comprises the following components in parts by weight: 87.99 parts of methanol with the concentration of 85 percent, 0.5 part of sodium citrate, 0.5 part of sodium ascorbate, 1 part of butyl acetate, 5 parts of minocycline hydrochloride, 2.5 parts of ciprofloxacin and 0.01 part of sodium dodecyl sulfonate. Wherein the weight ratio of minocycline hydrochloride is as follows: ciprofloxacin 2: 1.
The tube body of the vein indwelling needle is treated by the antibacterial liquid medicine, the treatment method is the same as that of the embodiment 1, and the tube body of the vein indwelling needle of the comparative example 5 is obtained.
Comparative example 6
An antibacterial liquid medicine for a venous indwelling needle comprises the following components in parts by weight: 87.99 parts of methanol with the concentration of 85 percent, 0.5 part of sodium citrate, 0.5 part of sodium ascorbate, 1 part of butyl acetate, 5.5 parts of rifampicin, 4.5 parts of chlorhexidine and 0.01 part of sodium dodecyl sulfonate.
The tube body of the vein indwelling needle is treated by the antibacterial liquid medicine, the treatment method is the same as that of the embodiment 1, and the tube body of the vein indwelling needle of the comparative example 6 is obtained.
Example 2: antibacterial testing
Antibacterial tests are respectively carried out on the vein indwelling needle tube bodies obtained in the example 1 and the comparative examples 1-6 by adopting a bacteriostatic ring test method: insert the culture medium flat board about body segment (5mm), cultivate 18 ~ 24h, measure antibacterial ring diameter size with slide caliper, the antibacterial effect is better for the bigger antibacterial ring diameter, and the test result is shown in Table 1.
TABLE 1 results of antibacterial tests against drug-resistant Staphylococcus aureus
According to the data in table 1, the diameter of the inhibition ring of the antibacterial liquid medicine used in the invention can still reach 8.46mm after 29 days, the effect is obviously better than that of the comparative example 6 which selects rifampicin and chlorhexidine as antibacterial medicines, and is also obviously better than that of the comparative example which selects minocycline hydrochloride and ciprofloxacin as antibacterial medicines but the proportion is different from that of the invention.
The above embodiments are preferred embodiments of the present invention, and all similar processes and equivalent variations to those of the present invention should fall within the scope of the present invention.
Claims (5)
1. An antibacterial liquid medicine for a venous indwelling needle is characterized by comprising the following components in parts by weight: 87.99 parts of methanol with the concentration of 85 percent, 0.5 part of sodium citrate, 0.5 part of antioxidant, 1 part of permeation enhancer, 5.5 parts of minocycline hydrochloride, 4.5 parts of ciprofloxacin and 0.01 part of sodium dodecyl sulfate.
2. The anti-bacterial medical solution for venous indwelling needles according to claim 1, wherein: the antioxidant is sodium ascorbate.
3. The anti-bacterial medical solution for venous indwelling needles according to claim 1, wherein: the penetration enhancer is butyl acetate.
4. A method for preparing an antibacterial liquid medicine for a venous indwelling needle according to any one of claims 1 to 3, comprising: dissolving 85% methanol, sodium citrate and an antioxidant at 30-50 ℃ for 10-30 min according to the weight parts of the raw materials, adding a penetration enhancer, continuously dissolving for 10-20 min, then adding minocycline hydrochloride and ciprofloxacin, stirring for 15-30 min, finally adding sodium dodecyl sulfate, and stirring for 10-15 min to obtain a finished product.
5. A venous indwelling needle, characterized in that: the pipe comprises a pipe body, wherein an antibacterial layer is attached to the inner wall of the pipe body, and the antibacterial layer is formed by soaking and drying the antibacterial liquid medicine as claimed in any one of claims 1 to 3.
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| CN201710649788.2A CN107593706B (en) | 2017-08-02 | 2017-08-02 | Antibacterial liquid medicine for venous indwelling needle and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102500033A (en) * | 2011-11-04 | 2012-06-20 | 北京迪玛克医药科技有限公司 | Anti-infection venous catheter and preparation method thereof |
| CN102946936A (en) * | 2010-03-30 | 2013-02-27 | 火花医学研究有限公司 | Drug releasing medical catheters, tubes, and devices |
| CN105031741A (en) * | 2015-03-03 | 2015-11-11 | 江苏海泽医疗科技发展有限公司 | Medical catheter with anti-infective drug coating and drug slowly-releasing function and preparing method thereof |
| CN105935459A (en) * | 2016-04-27 | 2016-09-14 | 广东百合医疗科技股份有限公司 | Anti-infectious tube body and intravenous catheter, and preparation method of tube body |
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- 2017-08-02 CN CN201710649788.2A patent/CN107593706B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102946936A (en) * | 2010-03-30 | 2013-02-27 | 火花医学研究有限公司 | Drug releasing medical catheters, tubes, and devices |
| CN102500033A (en) * | 2011-11-04 | 2012-06-20 | 北京迪玛克医药科技有限公司 | Anti-infection venous catheter and preparation method thereof |
| CN105031741A (en) * | 2015-03-03 | 2015-11-11 | 江苏海泽医疗科技发展有限公司 | Medical catheter with anti-infective drug coating and drug slowly-releasing function and preparing method thereof |
| CN105935459A (en) * | 2016-04-27 | 2016-09-14 | 广东百合医疗科技股份有限公司 | Anti-infectious tube body and intravenous catheter, and preparation method of tube body |
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