CN107592803B - 可触发形状记忆感应装置 - Google Patents
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- CN107592803B CN107592803B CN201680024926.1A CN201680024926A CN107592803B CN 107592803 B CN107592803 B CN 107592803B CN 201680024926 A CN201680024926 A CN 201680024926A CN 107592803 B CN107592803 B CN 107592803B
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
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| PCT/US2016/030020 WO2016178971A1 (en) | 2015-05-01 | 2016-04-29 | Triggerable shape memory induction devices |
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| CN107592803A CN107592803A (zh) | 2018-01-16 |
| CN107592803B true CN107592803B (zh) | 2021-01-22 |
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| US20170266112A1 (en) | 2014-06-11 | 2017-09-21 | Massachusetts Institute Of Technology | Residence structures and related methods |
| JP6666858B2 (ja) | 2014-06-11 | 2020-03-18 | マサチューセッツ インスティテュート オブ テクノロジー | 滞留構造体および関連方法 |
| CN118975972A (zh) | 2015-10-23 | 2024-11-19 | 林德拉治疗公司 | 用于治疗剂缓释的胃驻留系统及其使用方法 |
| BR112018011636B1 (pt) | 2015-12-08 | 2024-03-12 | Lyndra Therapeutics, Inc | Sistema de residência gástrico para liberação sustentada de um agente terapêutico |
| CN119925721A (zh) | 2016-05-27 | 2025-05-06 | 林德拉治疗公司 | 用于胃驻留系统的材料结构 |
| CN110022861B (zh) | 2016-09-30 | 2024-06-28 | 林德拉治疗公司 | 用于金刚烷类药物缓释的胃驻留系统 |
| AU2018279853B2 (en) | 2017-06-09 | 2024-07-04 | Lyndra Therapeutics, Inc. | Gastric residence systems with release rate-modulating films |
| US11648381B2 (en) | 2018-11-15 | 2023-05-16 | Massachusetts Institute Of Technology | Thermally controlled residence devices |
| US12142158B2 (en) | 2018-12-03 | 2024-11-12 | Lyndra Therapeutics, Inc. | Stomach simulating device |
| EP3941445A4 (en) | 2019-03-20 | 2023-08-02 | Lyndra Therapeutics, Inc. | CAPSULES AND CAPSULE COATINGS FOR GASOLINE DOSAGE FORMS |
| WO2021092487A1 (en) * | 2019-11-08 | 2021-05-14 | Lyndra, Inc. | Polymeric linkers for a gastric residence system |
| US20220249817A1 (en) * | 2021-01-29 | 2022-08-11 | Ohio State Innovation Foundation | Microrobots with distributed actuation |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU449029B2 (en) | 1969-08-28 | 1974-04-17 | Commonwealth Scientific And Industrial Research Organisation | Device for administration to ruminants |
| JPS5512411B2 (enExample) | 1974-03-12 | 1980-04-02 | ||
| US4767627A (en) | 1985-05-29 | 1988-08-30 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| IL87710A (en) | 1987-09-18 | 1992-06-21 | Ciba Geigy Ag | Covered floating retard form for controlled release in gastric juice |
| US5002772A (en) | 1988-05-31 | 1991-03-26 | Pfizer Inc. | Gastric retention system for controlled drug release |
| US5007790A (en) | 1989-04-11 | 1991-04-16 | Depomed Systems, Inc. | Sustained-release oral drug dosage form |
| JPH03163011A (ja) * | 1989-08-31 | 1991-07-15 | Yamanouchi Pharmaceut Co Ltd | 胃内滞留デバイス |
| US5840332A (en) | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
| GB9616267D0 (en) * | 1996-08-02 | 1996-09-11 | Ranier Ltd | Balloon catheter |
| AU751861B2 (en) | 1998-02-23 | 2002-08-29 | Massachusetts Institute Of Technology | Biodegradable shape memory polymers |
| US6488962B1 (en) | 2000-06-20 | 2002-12-03 | Depomed, Inc. | Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms |
| EP1416914A1 (en) | 2001-08-16 | 2004-05-12 | The State of Oregon acting by and through The State Board of Higher Education on behalf of Oregon State University | Expandable gastric retention device |
| KR100417163B1 (ko) * | 2001-11-12 | 2004-02-05 | 한국과학기술연구원 | 마이크로 캡슐형 로봇 |
| DE10224352A1 (de) * | 2002-06-01 | 2003-12-11 | Mueller Schulte Detlef | Thermosensitive Polymerträger mit veränderbarer physikalischer Struktur für die biochemische Analytik, Diagnostik und Therapie |
| CA2501345A1 (en) | 2002-10-11 | 2004-04-22 | Depomed Development, Ltd. | Gastro-retentive levodopa delivery form |
| EP1594475A1 (en) * | 2003-02-19 | 2005-11-16 | Mnemoscience GmbH | Self-expanding device for the gastrointestinal or urogenital area |
| EP1633281A1 (de) | 2003-06-13 | 2006-03-15 | Mnemoscience GmbH | Stents |
| DE10357742A1 (de) | 2003-06-13 | 2005-03-10 | Mnemoscience Gmbh | Temporäre Stents zur nicht-vaskulären Verwendung |
| ES2540929T3 (es) | 2005-02-01 | 2015-07-14 | Emisphere Technologies, Inc. | Sistema de administración de retención gástrica y liberación controlada |
| JP2006323082A (ja) | 2005-05-18 | 2006-11-30 | Canon Inc | 現像剤補給容器 |
| AU2006273679B2 (en) | 2005-07-26 | 2012-05-03 | Menachem P. Weiss | Extending intrabody capsule |
| EP1957052A2 (en) | 2005-10-25 | 2008-08-20 | Pharmascience Inc. | A gastric retention drug delivery system |
| WO2007106415A2 (en) | 2006-03-10 | 2007-09-20 | Massachusetts Institute Of Technology | Triggered self-assembly conjugates and nanosystems |
| US20070264307A1 (en) | 2006-05-15 | 2007-11-15 | Medtronic Vascular, Inc. | Biodegradable Modified Caprolactone Polymers for Fabricating and Coating Medical Devices |
| US20080249156A1 (en) | 2007-04-09 | 2008-10-09 | Palepu Nageswara R | Combinations of statins and anti-obesity agent and glitazones |
| CA2687979C (en) | 2007-05-25 | 2017-07-04 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of risperidone compounds |
| US8038659B2 (en) | 2007-10-17 | 2011-10-18 | The Invention Science Fund I, Llc | Disintegrating digestive tract interaction system |
| DE102007061342A1 (de) | 2007-12-17 | 2009-06-18 | Gkss-Forschungszentrum Geesthacht Gmbh | Artikel aus einem Formgedächtnis-Kompositmaterial, Verfahren zu seiner Herstellung sowie Verfahren zum Abrufen gespeicherter Formen |
| AU2009223061B2 (en) | 2008-03-11 | 2014-10-09 | Depomed Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
| US20130273135A1 (en) | 2008-03-25 | 2013-10-17 | University Of Utah Research Foundation | Controlled Release Combination Biomaterials |
| JP2012500230A (ja) | 2008-08-18 | 2012-01-05 | 北京天衡▲薬▼物研究院 | 胃内滞留薬物放出システム及びその製造方法と使用 |
| PL2349222T3 (pl) * | 2008-09-10 | 2017-08-31 | Sandoz Ag | Kapsułka z rozpuszczalnym elementem blokującym |
| US20110052700A1 (en) | 2009-08-31 | 2011-03-03 | Depomed, Inc. | Gastric retentive pharmaceutical compositions for immediate and extended release of levosulpiride |
| US20120321706A1 (en) | 2009-10-19 | 2012-12-20 | Intec Pharma Ltd. | Novel gastroretentive dosage forms of poorly soluble drugs |
| US8979887B2 (en) | 2012-02-24 | 2015-03-17 | Elwha Llc | Devices, systems, and methods to control stomach volume |
| AU2013290875A1 (en) | 2012-07-16 | 2015-02-05 | APET Holding B.V. | Gastro-retentive drug delivery system |
| US20170051099A1 (en) | 2014-04-29 | 2017-02-23 | The Brigham And Women's Hospital, Inc. | Polymeric materials for bio-applications |
| US20170266112A1 (en) | 2014-06-11 | 2017-09-21 | Massachusetts Institute Of Technology | Residence structures and related methods |
| JP6666858B2 (ja) | 2014-06-11 | 2020-03-18 | マサチューセッツ インスティテュート オブ テクノロジー | 滞留構造体および関連方法 |
| BR112018011636B1 (pt) | 2015-12-08 | 2024-03-12 | Lyndra Therapeutics, Inc | Sistema de residência gástrico para liberação sustentada de um agente terapêutico |
| CN119925721A (zh) | 2016-05-27 | 2025-05-06 | 林德拉治疗公司 | 用于胃驻留系统的材料结构 |
| CN110022861B (zh) | 2016-09-30 | 2024-06-28 | 林德拉治疗公司 | 用于金刚烷类药物缓释的胃驻留系统 |
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2016
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- 2016-04-29 AU AU2016257711A patent/AU2016257711A1/en not_active Abandoned
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2020
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2021
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| Publication number | Publication date |
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| AU2016257711A1 (en) | 2017-10-26 |
| JP2018515476A (ja) | 2018-06-14 |
| AU2020239662B2 (en) | 2022-08-04 |
| JP7122035B2 (ja) | 2022-08-19 |
| CA2983272A1 (en) | 2016-11-10 |
| US20160317796A1 (en) | 2016-11-03 |
| AU2020239662A1 (en) | 2020-10-22 |
| EP3288604A1 (en) | 2018-03-07 |
| CA2983272C (en) | 2023-08-29 |
| WO2016178971A1 (en) | 2016-11-10 |
| US10953208B2 (en) | 2021-03-23 |
| EP3288604B1 (en) | 2021-11-17 |
| HK1249869A1 (zh) | 2018-11-16 |
| CN107592803A (zh) | 2018-01-16 |
| JP2021119201A (ja) | 2021-08-12 |
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