CN107583095A - Preparation method of antimicrobial form fracture anchor stone cream bandage and products thereof and application - Google Patents
Preparation method of antimicrobial form fracture anchor stone cream bandage and products thereof and application Download PDFInfo
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- CN107583095A CN107583095A CN201710671808.6A CN201710671808A CN107583095A CN 107583095 A CN107583095 A CN 107583095A CN 201710671808 A CN201710671808 A CN 201710671808A CN 107583095 A CN107583095 A CN 107583095A
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Abstract
The present invention relates to preparation method of a kind of antimicrobial form fracture anchor stone cream bandage and products thereof and application, preparation including nano zinc oxide suspension, the preparation of PMMA/ half-H 2 O calcium sulphate slurries and gauze pasting, specifically using nano zine oxide as main antimicrobial component, itself and half-H 2 O calcium sulphate and PMMA are added in ethanol/purified water solution, and are configured to slurry.Slurry fractions are uniformly coated to gauze surface, a kind of medicine equipment with antibacterial activity are prepared, for the immobilization of the wounded limb after fracture bandaging.The present invention has the characteristics of technique is simple, cost is cheap, compatible existing coating, is stained with the application method of painting machine to improve production efficiency, and antibacterial effect is obvious.
Description
Technical field
The invention belongs to the preparation of biomaterial, a kind of preparation method for anchor stone cream bandage of being fractured more particularly to antimicrobial form
And products thereof and application, specifically using nano zine oxide as main antimicrobial component, it is uniformly coated to yarn with half-H 2 O calcium sulphate
Cloth surface, a kind of medicine equipment with antibacterial activity is prepared, for the immobilization of the wounded limb after fracture bandaging.
Background technology
At present, 70% ~ 99% cause dysentery, pneumonia, gonorrhoea and hospital infection epidemic link threaten for antibiotics resistance
To human health.However, nano granular of zinc oxide has by force to pathogenic bacteria such as Escherichia coli, staphylococcus aureus, Salmonellas
Strong suppression or killing action, while have toxicity selection selective and preferable biocompatibility, thus as additive or
Filler composition is applied to the fields such as antibacterial.Nano-particle has higher surface-active and huge specific surface area, adds it
The area for contacting and reacting with bacterium.In zinc oxide the metabolism of metal zinc ion by influenceing enzyme and DBP so as to pressing down
The survival rate of bacterium processed；Zinc oxide particles produce ROS materials in the cell（As hydrogen peroxide, hydroxyl radical free radical, negative oxygen ion and
Hydroperoxides etc.）, cause mycoderm to rupture, and then cause bacteriolysis or promote nano-particle to assemble in thalline and final
Cause bacterial death；Nano zine oxide has photocatalytic, when extraneous incident radiant energy exceedes its band gap（3.37eV）,
The photohole and light induced electron of high activity are produced in valence band and conduction band, with adsorbing in oxygen, hydroxyl and water of material surface etc.
Substance reaction, produce ROS materials and lethal effect is produced to bacterium.Compared with conventional oxidation Zinc material, nano zine oxide compares surface
Product is big, and chemism is high, and chemical purity and particle can be adjusted as needed
Medical plaster bandage is the upper gauze bandage for crossing slurry, and incorporation gesso is made, hardened into after water soaks in the short time
Type, there is very strong plastotype function.Orthopedist in order to allow fracture patient limbs reset after keep posture, it is necessary to medical gypsum
Bandage immobilized patients fracture site, thus plaster bandage is widely used in limbs fracture, abarticulation, congenital drop foot and hip
The treatment of abarticulation.Existing plaster bandage heaviness on the market is airtight, easily triggers bedsore.Antimicrobial nano technology is applied to
The making of plaster bandage, the germ caused by the reason such as bad, humid environment of gas permeability after plaster bandage is fixed can be reduced and grown
Raw and nosocomialtion probability.
The content of the invention
Present invention aims to overcome that the deficiency of existing plaster bandage, there is provided a kind of antimicrobial form fracture anchor stone cream bandage and
Its preparation method and application.
The preparation method of antimicrobial form fracture anchor stone cream bandage, it is characterised in that comprise the following steps：
（1）The preparation of nano zinc oxide suspension
Suspension is configured with A and B two parts：Part A, oil phase component 0.5% ~ 3.5%, emulsifier proportion 0.3% ~ 2.5%；B portions
Point, mass percent is 1% dispersion stabilizer, surfactant 0.2 ~ 1%, nano zine oxide 5 ~ 30%, fills out purified water extremely
100%；During specific preparation, in A containers, oil phase component, emulsifying agent are mixed by addition, it is Celsius to be heated to 70 ~ 120
Degree, and high-speed stirred, make each component fully dissolve, form the liquid of homogeneous transparent；In B containers, by dispersion stabilizer, surface
Activating agent is added to the water, stirs and forms homogeneous solution, then adds nanometer Zinc oxide powder, is heated to 70 ~ 100 degree, side heating
Side is stirred, and forms scattered slurries；Afterwards under fast stirring, 70 ~ 120 degree of part A is added to 70 ~ 100 degree of part B
In, homogenization 1 ~ 6 minute is carried out using high-shear homogenizer, room temperature is naturally cooled to, obtains suitable dispersing liquid；Oil phase part
It is divided into long chain alkane, alkene or alkynes, or above-mentioned long chain alkane, the alcohols of alkene or alkynes, ester derivative；Emulsifying agent can be
Tween, SPAN class surfactants；Dispersant can be carbomer, polyvinylpyrrolidone, cellulose；
（2）The preparation of PMMA/ half-H 2 O calcium sulphate slurries
PMMA particles are inserted in glass container, closed seal prevents solvent from volatilizing after adding absolute ethyl alcohol, by container environment temperature
25 degrees Celsius are adjusted to, after being stirred vigorously 5 hours with electric blender, the clarification slurry containing PMMA5% ~ 15% is obtained, by particle diameter
Added for 50um half-H 2 O calcium sulphate solid particle in above-mentioned PMMA slurries, be configured as the white containing half-H 2 O calcium sulphate 15 ~ 30%
Thick sizing liquor；
（3）Gauze pasting
Above two liquid proportional is sufficiently mixed, then roll of gauze is coated to two in above-mentioned steps using continuous starching machine
Kind slurries.In coating procedure, 10/mm of warp thread, the branch of the gauze of weft yarn 8/mm density as antibacterial plaster bandage are selected
Support group material；With 15 ms/min of gait of march starching, roll shaft portion and set to 60 degrees Celsius to vapor away slurry rapidly
In ethanol component, and plaster bandage can be made smooth.
Particle Size of Nanometer ZnO is 30nm.
A kind of antimicrobial form fracture anchor stone cream bandage, it is characterised in that be prepared according to method described above.
The application of antimicrobial form fracture anchor stone cream bandage.
Advantage of the present invention：Technique is simple, cost is cheap；Can compatible existing coating, be stained with the application method of painting machine, improve life
Produce efficiency；The addition of zinc oxide significantly improves the antibacterial effect of plaster bandage.
Brief description of the drawings
Fig. 1 is that the SEM of zinc oxide/PMMA dispersion liquids schemes；
Fig. 2 is the gauze section SEM figures containing Zinc oxide particles after half-H 2 O calcium sulphate solidification；
Fig. 3 is the microcosmic SEM figures of the half-H 2 O calcium sulphate containing Zinc oxide particles.
Embodiment
Embodiment 1
30g stearic acid and 20g Tween-80s are heated to 80oC, and mixed, heat while stirring, be allowed to fully melt,
The liquid of homogeneous transparent is formed, is component A；By the carbomer solutions of 25g 1%, 5g dodecyl sodium sulfates in another container
It is added to 100g nano zine oxides in pure water to 1000g, it is B component to carry 10% zinc oxide pure water dispersion liquid；Component A is poured into B
In component, handled 2 minutes with high-shear homogenizer, form 10% zinc oxide fluid dispersion；
By 5g PMMA grain dissolutions in 20g ethanol solutions, the solution of 20%PMMA contents is configured as；
The above-mentioned 10% zinc oxide pure water dispersion liquids of 100g are taken with after 5g 20%PMMA dispersion liquids, adding 20g CaSO4•1/2H2O
Solid, slurry is mixed into, is grown coated on 1000cm, on gauze wide 30cm, and dried rapidly coiled.Zinc oxide particles, institute's shape
Into PMMA coatings it is as shown in Figure 1.Gauze after coating is as shown in Figure 2.After gypsum gauze solidification, the half water stone containing zinc oxide
Cream microscopic appearance is as shown in Figure 3.
Embodiment 2
30g stearic acid and 20g Tween-80s are heated to 80oC, and mixed, heat while stirring, be allowed to fully melt,
The liquid of homogeneous transparent is formed, is component A；By the carbomer solutions of 25g 1%, 5g dodecyl sodium sulfates in another container
It is added to 150g nano zine oxides in pure water to 1000g, is B component；Component A is poured into B component, at high-shear homogenizer
Reason 2 minutes, form 15% zinc oxide fluid dispersion
By 5g PMMA grain dissolutions in 20g ethanol solutions, the solution of 20%PMMA contents is configured as
Take after the above-mentioned 10% zinc oxide pure water dispersion liquids of 100g and 5g 20%PMMA dispersion liquids, add 20g CaSO4•1/
2H2O solids, are mixed into slurry, are grown coated on 1000cm, on gauze wide 30cm, and dry rapidly coiled.
Embodiment 3
30g stearic acid and 20g Tween-80s are heated to 80oC, and mixed, heat while stirring, be allowed to fully melt,
The liquid of homogeneous transparent is formed, is component A；By the carbomer solutions of 25g 1%, 5g dodecyl sodium sulfates in another container
It is added to 200g nano zine oxides in pure water to 1000g, is B component；Component A is poured into B component, at high-shear homogenizer
Reason 2 minutes, form 20% zinc oxide fluid dispersion
By 5g PMMA grain dissolutions in 20g ethanol solutions, the solution of 20%PMMA contents is configured as
Take after the above-mentioned 10% zinc oxide pure water dispersion liquids of 100g and 5g 20%PMMA dispersion liquids, add 20g CaSO4•1/
2H2O solids, are mixed into slurry, are grown coated on 1000cm, on gauze wide 30cm, and dry rapidly coiled.
Embodiment 4
30g stearic acid and 20g Tween-80s are heated to 80oC, and mixed, heat while stirring, be allowed to fully melt,
The liquid of homogeneous transparent is formed, is component A；By the carbomer solutions of 25g 1%, 5g dodecyl sodium sulfates in another container
It is added to 250g nano zine oxides in pure water to 1000g, is B component；Component A is poured into B component, at high-shear homogenizer
Reason 2 minutes, form 25% zinc oxide fluid dispersion
By 5g PMMA grain dissolutions in 20g ethanol solutions, the solution of 20%PMMA contents is configured as
Take after the above-mentioned 10% zinc oxide pure water dispersion liquids of 100g and 5g 20%PMMA dispersion liquids, add 20g CaSO4•1/
2H2O solids, are mixed into slurry, are grown coated on 1000cm, on gauze wide 30cm, and dry rapidly coiled.
Embodiment 5
30g stearic acid and 20g Tween-80s are heated to 80oC, and mixed, heat while stirring, be allowed to fully melt,
The liquid of homogeneous transparent is formed, is component A；By the carbomer solutions of 25g 1%, 5g dodecyl sodium sulfates in another container
It is added to 300g nano zine oxides in pure water to 1000g, is B component；Component A is poured into B component, at high-shear homogenizer
Reason 2 minutes, form 30% zinc oxide fluid dispersion
By 5g PMMA grain dissolutions in 20g ethanol solutions, the solution of 20%PMMA contents is configured as
Take after the above-mentioned 10% zinc oxide pure water dispersion liquids of 100g and 5g 20%PMMA dispersion liquids, add 20g CaSO4•1/
2H2O solids, are mixed into slurry, are grown coated on 1000cm, on gauze wide 30cm, and dry rapidly coiled.
The gauze in above-described embodiment 1,2,3,4 and 5 after pasting is taken to do anti-microbial property checking：
10g peptones, 5g beef extracts, 5g sodium chloride and 20g agar are put into 1000ml distilled water, be adjusted to pH value to 7.2 ~
7.4,121oC high pressure steam sterilizations 20 minutes, import surface plate bed board.The plaster bandage prepared in Example 1,2,3,4 and 5
5cm*5cm areas, with the phosphate buffer of 0.1% Tween-80（0.03mol/L, PH7.2 ~ 7.4）It is diluted to 10-7Times, add
Enter in surface plate culture plate, be inoculated with third generation Escherichia coli, and cultivate 70 ~ 72 hours after observation experiment result, record clump count
Mesh.
As a result see the table below.
。
Claims (3)
- The preparation method of anchor stone cream bandage 1. antimicrobial form is fractured, the coating slurry on bandage, it is characterised in that with nano oxidized Zinc is main antimicrobial component, itself and half-H 2 O calcium sulphate and PMMA is added in ethanol/purified water solution, and be configured to slurry and be coated to Gauze surface, comprise the following steps：（1）The preparation of nano zinc oxide suspensionDivide A and B two parts configuration suspension, by mass percentage：Part A include 0.5% ~ 3.5% oil phase component and 0.3% ~ 2.5% emulsifying agent；Part B includes the dispersion stabilizer that mass percent is 1%, 0.2 ~ 1% surfactant, 5 ~ 30% nanometer Zinc oxide, remaining fills out purified water to 100%；During preparation, in A containers, oil phase component, emulsifying agent are mixed by addition, 70 ~ 120 DEG C, and high-speed stirred are heated to, forms the liquid of homogeneous transparent；In B containers, by dispersion stabilizer, surface-active Agent is added to the water, stirs and forms homogeneous solution, then adds nanometer Zinc oxide powder, is heated to 70 ~ 100 DEG C, is stirred in heating Mix, form scattered slurries；Afterwards under fast stirring, 70 ~ 120 DEG C of part A is added in 70 ~ 100 DEG C of part B, Homogenization 1 ~ 6 minute is carried out using high-shear homogenizer, room temperature is naturally cooled to, obtains suitable dispersing liquid；Wherein, it is described Oil phase component be long chain alkane, alkene or alkynes, or the long chain alkane, the alcohols of alkene or alkynes, ester derivative；Institute The emulsifying agent stated is tween, SPAN class surfactants；Dispersant is carbomer, polyvinylpyrrolidone, cellulose；（2）The preparation of PMMA/ half-H 2 O calcium sulphate slurriesPMMA particles are inserted in glass container, closed seal prevents solvent from volatilizing after adding absolute ethyl alcohol, by container environment temperature 25 degrees Celsius are adjusted to, after being stirred vigorously 5 hours with electric blender, is obtained containing 5% ~ 15% PMMA clear serums, by particle diameter Add in above-mentioned PMMA slurries, be configured as containing 15 ~ 30% half-H 2 O calcium sulphate white for 50um half-H 2 O calcium sulphate solid particle Thick sizing liquor；（3）Gauze pastingWill be above-mentioned（1）With（2）After two kinds of liquid proportionals are sufficiently mixed, it is coated in continuous starching machine on gauze, coated Cheng Zhong, select 10/mm of warp thread, the supporting base material of the gauze of weft yarn 8/mm density as antibacterial plaster bandage；With 15 meters/ The gait of march starching of minute, sizing roller is set to 60 DEG C to vapor away the ethanol component in slurry rapidly, and can make gypsum Bandage is smooth.
- 2. the preparation method of antimicrobial form fracture anchor stone cream bandage according to claim 1, it is characterised in that：Described nanometer Zinc oxide particle diameter is 30nm.
- A kind of 3. antimicrobial form fracture anchor stone cream bandaging product that preparation method according to claim 1 or claim 2 obtains.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1209988A (en) * | 1997-09-02 | 1999-03-10 | 沈钦云 | Production of pypsum bandage |
| CN1911196A (en) * | 2005-08-12 | 2007-02-14 | 章月根 | Method for producing plaster bandage |
| CN102120044A (en) * | 2011-03-10 | 2011-07-13 | 卢亢 | Chitosan and carbon nanometer tube compound surgical dressing and preparation method thereof |
| CN103693674A (en) * | 2013-11-27 | 2014-04-02 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of nanometer zinc oxide composite dispersion liquid |
| CN104116592A (en) * | 2013-04-25 | 2014-10-29 | 天津法莫西医药科技有限公司 | Dressing with nano-zinc oxide composite antibiosis layer |
| WO2016161997A1 (en) * | 2015-04-10 | 2016-10-13 | Ustav Organicke Chemie A Biochemie Av Cr, V.V.I. | Antimicrobial peptides and their use for the treatment of topical infections |
-
2017
- 2017-08-08 CN CN201710671808.6A patent/CN107583095A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1209988A (en) * | 1997-09-02 | 1999-03-10 | 沈钦云 | Production of pypsum bandage |
| CN1911196A (en) * | 2005-08-12 | 2007-02-14 | 章月根 | Method for producing plaster bandage |
| CN102120044A (en) * | 2011-03-10 | 2011-07-13 | 卢亢 | Chitosan and carbon nanometer tube compound surgical dressing and preparation method thereof |
| CN104116592A (en) * | 2013-04-25 | 2014-10-29 | 天津法莫西医药科技有限公司 | Dressing with nano-zinc oxide composite antibiosis layer |
| CN103693674A (en) * | 2013-11-27 | 2014-04-02 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of nanometer zinc oxide composite dispersion liquid |
| WO2016161997A1 (en) * | 2015-04-10 | 2016-10-13 | Ustav Organicke Chemie A Biochemie Av Cr, V.V.I. | Antimicrobial peptides and their use for the treatment of topical infections |
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