CN107569645A - The anaesthetic and its manufacture method of a kind of regulating gastointestinal - Google Patents
The anaesthetic and its manufacture method of a kind of regulating gastointestinal Download PDFInfo
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Abstract
The present invention relates to a kind of medicine and preparation method, i.e., the anaesthetic and its manufacture method of a kind of regulating gastointestinal, including the bulk drug banksia rose, it is characterised in that：The banksia rose is engaged with fructus amomi, fringed pink, and its weight is 180-220 parts of the banksia rose, 60-80 parts of fructus amomi, 80-120 parts of fringed pink.The banksia rose, fructus amomi, fringed pink dry powder mixing processed.Beneficial effect is：The drug effect of the banksia rose can be given full play to, stomach opsonic action significantly strengthens, and the disease such as not well to stomach pain, belch, nausea and vomiting, stool is evident in efficacy, and have no toxic side effect, prepare simply, cost is cheap, mechanism is definite, is easy to apply, it is expected to as the typical medicaments of stomach conditioning.
Description
Technical field
The present invention relates to a kind of medicine and preparation method, i.e., the anaesthetic and its manufacture method of a kind of regulating gastointestinal.
Background technology
Regulating gastointestinal is one of critical treatment means of Mongolian medicine, and targeted scope is mainly that " Ba Dagan " contains visitor in stomach partially
It is interior and mutually fighting causes stomach fire to decay with " Xi La " " conspicuous according to " and then stomach pain caused by dysfunction, belch, nausea and vomiting, big
Just it is not well to wait disease.With modern medicine alleged by acute or chronic gastritis, stomach or duodenal ulcer, gastroptosis, stomachache caused by gastrospasm
It is corresponding.Mongolian medicine's anaesthetic has the effect of unique, particularly anaesthetic banksia rose Saussurea costus to such disease, is treating
Among above-mentioned stomach trouble, larger effect has been played.But the compatibility medicinal material of the banksia rose is but very indefinite, the contained side of existing ancient books and records
Agent and spread among proved recipe among the people, it is many with the bulk drug species of banksia rose compatibility, but clinical effectiveness is uneven, and pharmacology is made
With having different versions, or even collide with each other, side effect superposition, and have different medicines of the same name, Tongfang not same amount the problems such as, to of doctor
People's skill requirement is too high, is unfavorable for popularization and application, and urgent need carries out checking arrangement.In addition, the active ingredient of the banksia rose is mostly volatile
Fragrance, existing anaesthetic is mostly play powder life to use, and pulverizing process can produce higher temperature, and volatile matter is largely lost in, and consumption is necessarily
Drug effect.It can be seen that the anaesthetic of coordinating intestines and stomach is badly in need of growing with each passing hour, modern science and technology is introduced, improves standardization, standardized level, is increased
Strong therapeutic effect.
The content of the invention
The purpose of the present invention be find it is more suitable coordinate with the banksia rose, stomach and intestine conditioning effect is more notable, to stomach pain,
Gas, nausea and vomiting, the bulk drug for the disease better efficacy such as not well of defecating, and then be made and have no toxic side effect, prepare simply, price is low
Honest and clean, mechanism is definite, is easy to the anaesthetic of the stomach and intestine conditioning of application.
It is a further object of the present invention to provide the preparation method of above-mentioned anaesthetic.
Above-mentioned purpose is realized by following technical scheme：A kind of anaesthetic of regulating gastointestinal, including the bulk drug banksia rose, it is special
Putting is：The banksia rose is engaged with fructus amomi, fringed pink, and its weight is 180-220 parts of the banksia rose, 60-80 parts of fructus amomi, fringed pink
80-120 parts.
The manufacture method of the anaesthetic of the regulating gastointestinal is：The banksia rose, fructus amomi, fringed pink dry powder mixing processed.
The manufacture method of the anaesthetic of the regulating gastointestinal is：The banksia rose and fructus amomi carry out low-temperature grinding system in the presence of liquid nitrogen
Powder, fringed pink propagandize drying hotly and beat airtight package after powder mixes with the powder of the banksia rose and fructus amomi below -10 DEG C.
The airtight package is filling capsule or wax-wrapped pill.
1-3 parts of 180-220 parts of the banksia rose, 60-80 parts of fructus amomi, 80-120 parts of fringed pink and Geniposide, deacetylation
1-3 parts of asperuloside acid methyl esters, 1-5 parts of Gardenia Yellow, 1-3 parts of ursolic acid, 2-5 parts of gallic acid, Fructus Piperis Longi oil 1-5
1-3 parts of part, pipering mixing.
1-3 parts of the Geniposide, 1-3 parts of deacetylation asperuloside acid methyl esters, 1-5 parts of Gardenia Yellow, ursolic acid
1-3 parts are substituted with 80-120 parts of replacements of cape jasmine, complete 80-120 parts of the pomegranate of 2-5 parts of use of gallic acid, the Fructus Piperis Longi oil
1-5 parts, 1-3 parts of pipering 60-80 parts of replacements are dialled by Bi.
1-3 parts of the Geniposide is different with hydroxyl with 5-8 parts of replacements of gardenoside, 1-3 parts of deacetylation asperuloside acid methyl esters
7-10 parts of gardenoside replacement, 1-3 parts of ursolic acid, 40-60 parts of replacements of loguat leaf, 2-5 parts of gallic acid with Chinese gall 60-
100 parts of replacements, 1-5 parts of Fructus Piperis Longi oil dial 40-60 parts of replacements by Bi, and 10-20 parts with pepper of 1-3 parts of pipering substitutes.
The beneficial effects of the invention are as follows：The drug effect of the banksia rose can be given full play to, stomach opsonic action significantly strengthens, to stomach
Pain, belch, nausea and vomiting, the disease such as not well of defecating are evident in efficacy, and have no toxic side effect, and prepare simply, cost is cheap, and mechanism is true
Cut, be easy to apply, it is expected to as the typical medicaments of stomach conditioning.
Embodiment
The first embodiment：180-220 parts of the banksia rose, 60-80 parts of fructus amomi, 80-120 parts of fringed pink are taken by weight.It is preferred that
200 parts of the banksia rose, 70 parts of fructus amomi, 100 parts of fringed pink, powder processed is dried, cross more than 80 mesh and sieve, mixed.
Adult is each taking 2-5g, and 2 times a day, 10 are a course for the treatment of.
The property of medicine is analyzed：
Banksia rose Aucklandia lappa Decne, it is the common name of feverfew Aplotaxis auriculata and radix jurineae.Aplotaxis auriculata（Scientific name：
Saussurea costus）, also known as costus root or dutchmanspipe root, belong to composite family Genus Saussurea.Radix jurineae（Scientific name：Dolomiaea
souliei）It is the plant of composite family Dolomiaea, rhizome is used as medicine.Containing dehydro-α-curcumene（dehydrocostuslactone）, wood
Fragrant alkene lactone（costunolide）Deng volatile oil and several amino acids, there is middle benefit gas promoting qi circulation and relieving pain, reinforcing spleen to promote digestion leads stagnant work(
Effect.Cure mainly feeling of stuffiness in chest hypochondriac pain, abdominal distention, weight after dysentery, accumulation of food in the stomach and intes tine due to indigestion, vomiting and diarrhea, cold hernia stomachache, oedema, the disease such as tinea pedis.
Fructus amomi (Amomum villosumLour.) also known as:Fructus Amomi, Changtai fructus (Fujian), also known as cardamom,
The fruits and seedses of perennial herb zingiberaceous plant, acrid flavour are warm-natured.Channel tropism：Returns spleen warp, stomach, kidney channel.It is one that the traditional Chinese medical science is commonly used
Taste aromaticity medicinal material.Seeds of Amomum Villosum contains volatile oil, contains Bronyl acetate, camphor, lauro lene, limonene, nopinene, bitter orange oil in oil
Alcohol (nerolidol) and australene, amphene, eucalyptol, linalool, α-pepper alkene, guaiol (guaiaol) etc..It is another to contain Huang
Ketones component.Fructus amomi mainly acts on the stomach, kidney and spleen of human body, can promoting the circulation of qi seasoning, and stomach is amusing.Cure mainly the taste stagnation of the circulation of vital energy, place
Food does not disappear, swollen ruffian of suffering from abdominal pain, and dysphagic vomiting is cold to rush down the diseases such as cold dysentery, pernicious vomiting, fetal irritability.
Fringed pink Dianthus superbus L. alias:High mountain fringed pink, Caryophyllaceae, Carnation perennial herb, fringed pink are fresh
Careless moisture content 77.3%, thick protein 2.62%, NFE 13.18%, crude fibre 4.95%, coarse ash 11.09%, phosphoric acid
0.13%.Also material containing retinoid, its content are calculated as 0.3333% by vitamin A.In addition a small amount of alkaloid is still contained, through ripple
Spectrum is analyzed and identified as Physcion, rheum emodin, 3,4- methyl dihydroxy benzoates, 3- (3,4- dihydroxy phenyls) propionic acid first
Ester, anthemisol and rheum emodin -8-O- glucosides.With the effect of clearing away heat and promoting diuresis, blood-breaking is stimulated the menstrual flow, urinary obstruction is cured mainly, is drenched
Disease, oedema, Amenorrhea, carbuncle swells, hot eyes are hidden from view, the disease such as contamination sore.In recent years it is demonstrated experimentally that fringed pink has following pharmacological action：
1st, diuresis.Fringed pink is to rabbit, anesthesia and anesthetized dog does not have certain diuresis, 2 gs/kg of fringed pink fringe decoction
Gavage, the rabbit of the salt water retention urine volume in 6 hours can be made to increase to 156.6%, chloride increases to 268.2%, fringed pink decoction
Anesthetized dog urine volume is set to increase by 1-2.5 times, anesthetized dog urine volume does not increase by 5-8 times；
2nd, to the effect of intestinal tube.Isolated rabbit intestines, anesthetized dog intestinal tube in place, the chronic intestinal fistula of dog experiment in observe:Fringed pink is decocted
Agent has significant excitation to intestinal tube, and isolated rabbit intestines are mainly manifested in tensity rising, and anesthetized dog intestinal tube in place and dog are chronic
Intestinal fistula then shows as enterocinesia enhancing, and tension force has no too much influence；
3rd, on cardiovascular influence.Fringed pink has very strong inhibitory action to isolated frog heart, the rabbit heart, and fringed pink fringe decoction has to anesthetized dog
Antihypertensive effect；
4th, on bilharzial influence.10% fringed pink decoction in vitro can kill blood fluke polypide in 8-12 minutes；
5th, immunization.The water extract of fringed pink and low polar extract can suppress the secretion of human body b cell immunoglobulin；
6th, bacteriostasis.The water and ethanol extract of fringed pink to Escherichia coli, salmonella paratyphi, staphylococcus aureus,
Hay bacillus and proteus have inhibitory action；
7th, desinsection.Fringed pink acetic acid ethyl acetate extract has very strong killing root-knot nematode activity；
8th, anti peroxidation of lipid.Fringed pink decoction is obvious to rat liver homogenate Lipid peroxidation.
Compatibility is analyzed：
The banksia rose and fructus amomi are fragrant medicine, can treat stomach trouble, and are emphasized particularly on different fields, therefore it is desirable that the banksia rose and fructus amomi share
Produce Overlay.But clinical trial effect is unsatisfactory.Analyzing reason is：Because both side effects are close, share
Side effect is superimposed afterwards.Recorded according to ancient books and records, the banksia rose deficiency of Yin body fluid deficiency careful clothes of person：《Bencao Jingshu》Be loaded with " deficiency syndrome of the lung has a hot person, it is careful not
Violate it.Vigour is collapsed and yin asthenia generating intrinsic heat, and all diseases have heat, the pained fiery person's disabling of category ",《Book on Chinese herbal medicine must be matched somebody with somebody》" internal organs are scorching, stomach Qi for record
Valetudinarian, invalid disables ".The fructus amomi deficiency of Yin has hot person to avoid clothes：《Bencao Jingshu》Carry " it is all stomachache category fire, the hot summer weather that diarrhea obtains, movement of the foetus due to
Blood-head, pharyngalgia due to fiery scorching, infantile rectocele due to the deficiency of vital energy, turgor due to damp and hot, upper gas cough compel because fire rushes lung without due to
Cold air is hindered, and must all examine discriminating in detail, it is difficult to general to use.”《Medicineization justice》" lung has volt fire to avoid it to load.”《Book on Chinese herbal medicine must be matched somebody with somebody》Carry " the deficiency of vital energy
Lung completely disables ".Syndrome of deficiency of stomach yin, refer to the syndrome that deficiency of stomach-Yin is showed.Prolonged long by stomach trouble more and be not cured, or pyreticosis later stage yin-fluid is not
It is multiple, or addiction is pungent usually, or feelings will is unsuccessful, qi depression transforming into fire makes stomach-Yin consumption wound and caused.Clinical manifestation vague epigastralgia, famine are not intended to
Food, dryness of the mouth and throat, dry and hard excrement, or gastral cavity ruffian are not relaxed, or are retched and seen inverse, red tongue with a little fluid, thready rapid pulse.Assertive evidence is with the common disease of stomach trouble
Shape and yin deficiency syndrome are shown in for dialectical main points altogether.Deficiency of stomach-Yin, then stomach sun is partially high, raw in abnormal heat, in the strongly fragrant stomach of heat, disorder of stomach-energy, causes gastral cavity
Portion's secret anguish, anorexia.Stomach-Yin virtual loss, throat can not be above moistened, then dryness of the mouth and throat；Under can not make moist large intestine, put dry and hard excrement.
Stomach loses yin-fluid and moistened, disorder of stomach-energy, it is seen that gastral cavity ruffian is not relaxed, disturbance of heat due to deficency of YIN, stomach Qi upward reversal, it is seen that retching and hiccup.Red tongue with a little fluid, arteries and veins
It is the sign of yin asthenia generating intrinsic heat as counting accurately.Yin asthenia generating intrinsic heat person occupies significant proportion in clinical practice, and what the banksia rose and fructus amomi shared
Indication is on the low side, and fecula shares especially unsuitable particularly in the case of without other compatibilities.It can be seen that find can eliminate the banksia rose,
The side effect that fructus amomi shares, the bulk drug for retaining both Overlays be the banksia rose, fructus amomi share produce effect of optimization before
Carry, and the important goal of this research.
Found through many experiments, fringed pink is to eliminate the suitable drugs that the banksia rose, fructus amomi share side effect.The diuresis of fringed pink
Directly related with heat in elimination, the treatment of the function for stomach trouble such as the antibacterial of fringed pink, desinsection, enhancing immunologic function is of great advantage.
After this point has obtained the support of zoopery, the confirmation for clinical trial of getting back.
Clinical trial in 2014-2015 years 128, it is stomach pain, belch, nausea and vomiting, the typical case's trouble for defecating not well
Person, four groups are randomly divided into, using banksia rose single, fructus amomi single as control group, the banksia rose：Fructus amomi=20：7 and the banksia rose：Fructus amomi：Fringed pink=
20：7:10 be two experimental groups, and adult often takes 5-8g, takes day 2 times, is treated three weeks, is effective using symptom mitigation, symptom disappears
To cure, that symptom is not kept to is invalid, and exacerbation of symptoms is discontinued and press invalidation, is evaluated with reference to other test ratings, experiment
As a result it is as follows：
Calculation formula：Cure rate=（Healing number/sum）× 100%, total effective rate=（Sum-invalid number）/ sum ×
100%。
It is visible by above-mentioned experiment, less than the effect of the banksia rose single the effect of banksia rose and fructus amomi compatibility, still there is disease in experiment
Shape aggravates the case of drug withdrawal in two weeks up to 6 people, and significantly leading the effect of banksia rose fructus amomi fringed pink, has no exacerbation of symptoms and midway
Drug withdrawal person, absolutely prove that fringed pink has the function that to maximize favourable factors and minimize unfavourable ones, promoted what is beneficial and abolish what is harmful for banksia rose fructus amomi.
Second of embodiment：The processing method that medicine is improved on the basis of the first embodiment, it is contemplated that the banksia rose and sand
The active ingredient of benevolence contains substantial amounts of volatile oil, and heat can be produced at normal temperatures by crushing, and increase volatile quantity, reduce drug effect, therefore adopt
Fly method with low-temperature grinding to process.
The mode of low-temperature grinding is a lot, but preferably with the quick-frozen effective component that could retain medicinal material to greatest extent.
Conditional unit, liquid nitrogen plant can be used, cause less than -80 DEG C of low temperature environment, by medicinal material quick freeze, then carry out powder
It is broken.Can also in the presence of liquid nitrogen quick freeze, using liquid nitrogen freezers carry out Freezing smashing.Liquid directly can fill liquid nitrogen
Enter the banksia rose and fructus amomi is freezed and carries out low-temperature grinding powder again.
Fringed pink can be propagandized hotly to dry and beat powder because non-volatile thing composition is without carrying out Freezing smashing, then with the banksia rose and fructus amomi
Powder mixed below -10 DEG C after airtight package.The airtight package can be filling capsule or wax-wrapped pill.It is demonstrated experimentally that this
The effect that sample is made is greatly improved than the volatile oil content of Normal practice, and curative effect is remarkably reinforced.2015 clinical laboratory datas are as follows：
| Medicine | Number of cases | Cure | Effectively | It is invalid | Cure rate（%） | Total effective rate（%） |
| Banksia rose fructus amomi fringed pink | 32 | 16 | 6 | 10 | 50 | 68.8 |
| Banksia rose fructus amomi fringed pink (cold system) | 32 | 17 | 7 | 8 | 53.1 | 75.0 |
Calculation formula：Cure rate=（Healing number/sum）× 100%, total effective rate=（Sum-invalid number）/ sum ×
100%。
Wherein have no exacerbation of symptoms and midway drug withdrawal person, but have two weeks healing persons 5, it is seen that the drug effect of Freezing smashing is worth
Certainly.
The third embodiment：On the basis of previous embodiment, the examination banksia rose, fructus amomi, fringed pink compatibility and other bulk drugs
The possibility of compatibility, and introduce modern technologies and traditional mongolian medicine is improved.With the plurality of raw materials medicine with banksia rose compatibility and
There may be the bulk drug of good result kind more than 40 to be screened for theory analysis, particularly to show preferable bulk drug carry out into
Analysis, finds active ingredient, further improves drug effect, reduces formulation, bulk drug resource is fully utilized.By big
Amount screening, find following preferable combination.
1-3 parts of 180-220 parts of the banksia rose, 60-80 parts of fructus amomi, 80-120 parts of fringed pink and Geniposide, deacetylation Propeller Blade
Careless 1-3 parts of glucoside acid methyl esters, 1-5 parts of Gardenia Yellow, 1-3 parts of ursolic acid, 2-5 parts of gallic acid, 1-5 parts of Fructus Piperis Longi oil, Hu
1-3 parts of mixing of green pepper alkali.
Geniposide（Genipin）It is the reactive compound in gardenia fruit extract, it is demonstrated experimentally that Ni Jingping can be released
Suppression of the UCP2 to insulin releasing, promotes more insulin releasings, improves type ii diabetes symptom, and have liver protection, decompression,
The functions such as defaecation.
Deacetylasperulosidic acid methyl esters (Deacetylasperulosidic acid metbylester, DAM) has and rushed down
Lower effect, the effective dose 50 of mouse is 0.53g/kg, starts to suffer from diarrhoea after taking 6 hours.
Gardenia Yellow gardenia yellow pigment, molecular formula C16H11N2NAO4S.Main component is safflower
Element and crocetin, are a kind of water-soluble carotenoids, are easily absorbed by the body, vitamin A can be converted into human body.
The deficiency of body vitamin can be supplemented.Gardenia Yellow plays the role of similar cape jasmine, has capable of clearing heat and reducing internal heat, cool blood cholagogic, drop
The effect of low cholesterol, there is certain healthcare function, be a kind of to integrate coloring, nutrition, the natural plant of multifunctional health
Look for element.
Ursolic acid (ursolic acid) can substantially suppress HL-60 cells propagation, can induce its apoptosis；Mouse can be made
Macrophage phagocytic function significantly improves.In vivo studies proves that ursolic acid can be remarkably reinforced body's immunity.Illustrate black bearberry
The antitumor action of acid is extensive, it is most likely that as the effective new anticancer drug of low toxicity.And with antibacterial, anti-inflammatory, drop serum
Transaminase, anti-diabetic, cooling and the effect such as stable.
Gallic acid（English：Gallic acid）Also known as gallic acid or gallate, are a kind of organic acids, chemical formula C6H2
(OH) 3COOH, it is seen that in the plants such as Chinese gall, lacquer tree, tea.It is used as medicine and preferably uses its pharmaceutical grade intermediate.Li Xiaoling etc. is reported
Gallic acid has the various biologicals such as anti-inflammatory, anti-mutation, anti-oxidant, Green Tea Extract active；Gallic acid has anti-simultaneously
Function of tumor, the transfer of mastocytoma can be suppressed, so as to extend life cycle；And relatively suitable trypanocidia candidate's medicine
Thing；There is protective effect to liver, the liver physiology of tetrachloro-methane induction and biochemical transformation can be resisted；Suppression can be passed through
The generation induction of vascular endothelial dependence of endothelial NO processed is shunk and to endothelium-dependent relaxation.Separately there are data to show with prescribe medicine
Reason acts on：
1. anti-bacteria and anti-virus:In vitro to staphylococcus aureus, sarcine, α-type streptococcus, Neisser's coccus, green pus bar
Bacterium, bacterium flexneri, typhoid bacillus Hd, paratyphosum Bacterium A etc. have inhibitory action, and its Mlc is 5mg/ml.In vitro, exist
There is bacteriostasis to 17 kinds of fungies under 3% concentration, infected by influenza also has certain inhibitory action；
It is 2. antitumor:There is high inhibition effect to the mouse lung adenoma caused by morpholine plus sodium nitrite.
Fructus Piperis Longi oil, it is the main component among Bi groups of fruits of Piperaceae pepper platymiscium.According to relevant information, Bi dials volatile oil
With antibacterial action：It is husky to staphylococcus aureus, hay bacillus, Bacillus cereus, tubercle bacillus, shigella dysenteriae, typhoid fever
Door Salmonella T and B, yolk color eight folds bacterium etc. and influenza virus inhibitory action.Bi roots of grass volatile oil can improve small under reduced pressure
The hypoxia-bearing capability of mouse, medication group survival rate are 93.1%, control group 18.6%.Normal pressure anoxia tolerance test shows that the Bi roots of grass volatilizees
Oil can extend the time-to-live 37.8% of mouse；Improve the oxygen consumption increased mouse survival time caused by isopropyl kidney parathyrine, it is comparable
Control group improves 30%.To hypoxia mice caused by natrium nitrosum, 64% life span can be improved.Extend potassium cyanide poisoning mouse
Death time, raising 66.6% compared with control group, the histanoxia death time to caused by folder closes mouse bilateral carotid,
Compared with control group, 58.3% can be extended.Fructus Piperis Longi oil unsaponifiable matter has the excretion for promoting biliary cholesterol, reduces serum and liver
The effect of dirty cholesterol
Pipering is also known as (E, E) -1- [5- (1,3- benzodioxolane -5- bases) -1- oxos -2,4- pentadienyl]-piperidines, it
It is a kind of chemical intermediate, its molecular formula is C17H19NO3, molecular weight 285.3377.According to relevant information, in kinds of experiments
Gastric injury, such as stress, ethanol, Indomethacin induction, hydrochloric acid stimulate and pylorus ligation gastric ulcer model on, the third of pepper fruits
Ketone extract and isolated pipering show preferable antagonism, can be in dose-dependently to suppress ulcer surface
The activity of product, gastric acid inhibitory and pepsin A.Pipering substantially resists mouse caused by the catharsis agent such as castor oil and magnesium sulfate
Diarrhoea, this demonstrate that pipering traditionally treats the usage of dysentery.
Clinical trial in 2013 36, it is stomach pain, belch, nausea and vomiting, not well typical patient of defecating, is grown up
5-8g is often taken, is taken day 2 times, is treated three weeks, be effective using symptom mitigation, symptom disappearance is healing, symptom is not kept to invalid, disease
Shape, which aggravates to be discontinued, presses invalidation, is evaluated with reference to other test ratings, experimental result is as follows：
| Medicine | Number of cases | Cure | Effectively | It is invalid | Cure rate（%） | Total effective rate（%） |
| This example medicine | 36 | 22 | 7 | 7 | 61.1 | 80.6 |
Calculation formula：Cure rate=（Healing number/sum）× 100%, total effective rate=（Sum-invalid number）/ sum ×
100%。
Wherein have no exacerbation of symptoms and midway drug withdrawal person, but there are 9 to cure within two weeks, it is seen then that the markedly fast of this example medicine, to treat
Effect is notable.
4th kind of embodiment：1-3 parts of Geniposide, 1-3 parts of deacetylation asperuloside acid methyl esters, 1-3 parts of ursolic acid,
80-120 parts with cape jasmine of 1-5 parts of Gardenia Yellow substitutes.80-120 parts of replacements of the full pomegranate of 2-5 parts of use of gallic acid.Bi is dialled
1-5 parts of oil, 1-3 parts of pipering dials 60-80 parts of replacements by Bi.Form new compatibility：180-220 parts of the banksia rose, fructus amomi 60-
80 parts, 80-120 parts of fringed pink, 80-120 parts of cape jasmine, complete 80-120 parts of pomegranate, Bi dials 60-80 parts.
Cape jasmine（Scientific name：Gardenia jasminoides Ellis）Alias：Yellow Fructus Gardeniae, mountain Cape jasmine, white toad, it is that Rubiaceae is planted
The fruit of thing cape jasmine.Fruit constituents containing iridoid：Gardenoside (gardenoside), all square rafter glucoside (geniposide), all
The plain gentiobiose glucoside (genipin-1-gentiobioside) of square rafter, shanzhiside (shanzhiside), cape jasmine ketone glucoside (gardo-
Side), Chinese Fevervine Herb time glucoside methyl esters (scandoside methyl ester), all square rafter glucoside (geniposidic acid), goes
Acetyl group asperuloside acid (deacetyl asperulosidic acid), deacetylasperulosidic acid methyl esters (methyl
Deacetyl asperulosidate), the 〃 of 10- acetyl group all square rafter glucoside (10-acetylgeniposide) 6-to coumaric acyl
All square rafter (6 〃-p-coumaroyl genipin gentiobio-side).Contain acrylic component again：Green original
Sour (chlorogenic acid), its quininic acid (3, -4-di-O-caffeoyl quinic acid) of 3,4- bis--O- caffeoyls,
3-O- coffee acyl -4-O- mustard acyls quininic acid (3-O-caffeoyl-4-O-sinapoyl quinic acid), 3,5-
Two-O- coffee acyls -4-O- (methyl of 3- hydroxyls -3) glutaryl quininic acid [3,5-di-O-caffeoyl-4-O- (3-
Hydroxy-3-methyl) glutaroyl quinic acid], 3,4- bis- coffee acyl -5- (3- hydroxy-3-methyl glutaryls
Base) quininic acid [3,4-dicaffeovl-5- (3-hydroxy-3-methyl glutaroyl) quinic acid], safflower
Sour (cro-cetin), crocin (crocin), ursolic acid (ursolic acid), crocin glycoside (crocin
Glucoside) etc..Also contain flavones ingredient：Rutin (rutin) and PEARLITOL 25C (D-mannitol), cupreol (β-
Sitosterol), choline (choline), nonacosane (nonacosane), lutein (xanthophyll) etc..Pericarp and
Also containing gardenoside, all square rafter glucoside, all square rafter glucoside, all square rafter in seed.Flower contains Triterpenoid：Gardenia
Acid (gradenlic acid) A, B and gardenia acid (gardenic acid) leaf contain gardenoside, all square rafter glucoside, cape jasmine aldehyde
(cerbinal), MDJ (methyl dihydrojasmonate), acetic acid benzyl lemon imonene (limonene), fragrant camphor tree
Alcohol (linalool) etc..Rhizome contains PEARLITOL 25C, oleanolic acid (oleanolic acid), stigmasterol (sing-
masterol).The fruit of cape jasmine is traditional Chinese medicine, the l batch medicine-food two-purpose resources that the category Ministry of Public Health promulgates, have protect liver, cholagogic,
The effect such as decompression, calm, hemostasis, detumescence.It is usually used in treating icteric hepatitis, bruise, hypertension, glycosuria in tcm clinical practice
The diseases such as disease.
The fruit that full pomegranate is Punicaceae plant pomegranate punicagranatumL, main component are tannin, not eaten
Sub- acid, resin etc..With puckery intestines, hemostasis, expelling parasite, chronic diarrhea, protracted dysentery and other effects are controlled.
It is the prematurity fruit ear that Piperaceae plant Bi is dialled that Bi, which dials (Piper Longum L),.Piper longum fruits contain pipering
（piperine）, palmitic acid（Palmiticacid), tetrahydropiperic acid（TeTCMLIBahydropipericacid), 11 carbon-
1- alkene -3,4- methylene dioxy benzene（L-undecylenyl-3,4-methylene-dioxybenzene）, piperidines（piperine）,
Volatile oil, the anti-4- acid amides of N- isobutyl groups decadinene-anti-2-（N-isobutyldeca-TCMLIBans-2-TCMLIBans-4-
dienamide）, sesamin（sesamin）, Bi roots of grass nonadiene piperidines（pipernonaline）, the carbon triolefin piperidines of the Bi roots of grass 11
（piperun-decalidine）, the bright peaceful alkali of the Bi roots of grass（piperlonguminine）, the bright peaceful alkali of the dihydro Bi roots of grass（di-
hydropiperlonguminine）, piperamide（pipercide）, Guinea's piperamide（guineensine）, N- isobutyls
Carbon -2, the 4- diene amide of base 18（N-isobutyloc-tadeca-2（E）, 4（E）- dienamide), N- isobutyl groups 20
Carbon -2,4- diene amide ［ N-isobutyleicosa-2（E）, 4（E）- dienamide ］, the carbon -2,4 of N- isobutyl groups 20,8- tri-
Acrylamide ［ N-isobutyleicosa-2（E）, 4（E）, 8（Z）- TCMLIBienamide ］, Bi roots of grass nonyl triolefin piperidines
（dehydropipernonaline）.Stem contains piplartine（piplar-tine,piperlongumine）.Contain long handle in seed
Pipering（sylvatine）, double different Eudesmins（Diaeudesmin ］.Anaesthetic thinks that this moral character is hot, it is pungent to narrow, and has regulating the qi flowing in the channels wide
In, clear grain the effect of returning essence.
Geniposide is the enteral transformation thing of gardenoside, and deacetylation asperuloside acid methyl esters is gardenoside
(Gardenoside) gastric juice conversion product, and gardenoside, gardenoside, ursolic acid, Gardenia Yellow can be among cape jasmines
Extraction, therefore use cape jasmine to substitute.Gallic acid content in full pomegranate is more, therefore can be substituted with full pomegranate.Fructus Piperis Longi oil, pepper
Alkali is the active ingredient that Bi is dialled, therefore can be dialled and substituted with Bi.Bi dial contained pipering can warming spleen and stomach for dispelling cold, it is cold that cape jasmine can be cleared up
Gas.The major advantage of above-mentioned replacement is to reduce cost, and still has preferable therapeutic effect.
Clinical trial in 2016 36, it is stomach pain, belch, nausea and vomiting, not well typical patient of defecating, is grown up
5-8g is often taken, is taken day 2 times, is treated three weeks, be effective using symptom mitigation, symptom disappearance is healing, symptom is not kept to invalid, disease
Shape, which aggravates to be discontinued, presses invalidation, is evaluated with reference to other test ratings, experimental result is as follows：
| Medicine | Number of cases | Cure | Effectively | It is invalid | Cure rate（%） | Total effective rate（%） |
| This example medicine | 36 | 21 | 7 | 8 | 58.3 | 77.8 |
Calculation formula：Cure rate=（Healing number/sum）× 100%, total effective rate=（Sum-invalid number）/ sum ×
100%.Wherein have no exacerbation of symptoms and midway drug withdrawal person, but there are 4 to cure within two weeks, it is seen then that the markedly fast of this example medicine, curative effect
Significantly.
5th kind of embodiment：1-3 parts of the Geniposide is substituted for 5-8 parts with gardenoside, deacetylation asperuloside acid first
1-3 parts of ester is substituted with 7-10 parts of replacements of gardenoside, 40-60 parts with loguat leaf of 1-3 parts of ursolic acid, gallic acid 2-5
Part with 60-100 parts of Chinese gall replacement, 1-5 parts of Fructus Piperis Longi oil dials 40-60 parts of replacements by Bi, 1-3 parts of pipering with pepper 10-
20 parts of replacements.Form new compatibility：180-220 parts of the banksia rose, 60-80 parts of fructus amomi, 80-120 parts of fringed pink, 5-8 parts of gardenoside,
7-10 parts of gardenoside, 40-60 parts of loguat leaf, 60-100 parts of Chinese gall, Bi dial 40-60 parts, 10-20 parts of pepper.
Loguat leaf (scientific name：Eriobotrya japonica Thunb.) be rosaceous plant loquat leaf.Also known as bar
Leaf, Lu Juye.Leaf contains volatile oil, and principal component is nerolidol (Nerolidol) and fanesol (Farnesol), also a and
B firpenes, amphene, laurene, to P-cymene, linalool, a- ylangenes, a and B farnesenes, camphor, nerol, Mang ox
Alcohol, a- pilgerols, elemol, cis- B, r- hexenols and linalool oxide.Also (Amygdalin, black bearberry containing amygdalin
Acid, oleanolic acid, tartaric acid, citric acid, malic acid, tannin, vitamin B and C etc..(Sorbitol) containing D-sorbite again.Pi
Rake leaf enters stomach, kind clearing away the stomach-heat, drops stomach Qi and plays the preventing or arresting vomiting sound of vomiting, controls the effect of hiccup.
Chinese gall scientific name (Rhus chinensis Mill.), also known as hundred worm storehouses, fermented Chinese gall herb and tea leaves, gall, it is Homoptera aphid
The horned gall aphid or melaphis peitan Tsai et Tang female adult of section parasitize Anacardiaceae plant " Chinese sumac " and its belong to the tender leaf or petiole of other plant together, thorn
Hinder and generate a kind of cryptomere consor thing insect gall, the gained after drying and drying again.It is more than that Chinese gall can treat rush down dysentery, controls prolapse of the anus not
Receive, postpartum intestines are de- to wait disease.
Pepper（Scientific name：Piper nigrum）, also known as black river, it is that one kind of Piperaceae is bloomed liana, pepper fruits
Containing a variety of amides compounds：Pipering, piperamide, piperyline, piperettine alkali, papper oil alkali B, Guinea's piperyl
Amine, false piperlongumine A, piperic acid glue-C5：l（2E）, piperamide-C7：l（6E）, piperamide-C7：2（2E, 6E）, pepper
Acid amides-C9：1（8E）, piperamide-C9：2（2E, 8E）, piperamide-C9：3（2E, 4E, 8E）, 1 [decyl-（2E, 4E）- diene
Acyl] tetrahydrochysene adjoins and coughs up, l- [12 carbon-（2E, 4E）- diene acyl] nafoxidine, the trans asafoetide acyl piperidines of N-, class asafoetide acyl piperidines,
Two hydrogen species asafoetide acyl piperidines, pellitorine, tri- acrylamide of carbon -2E, 4E, 8Z- of N- isobutyl groups 20, the carbon -2E of N- isobutyl groups 18,
4E- diene amides, the trans feruloyltyramines of N-, class is to coumaric acyl piperidines, trans- 2 diene amides of N- isobutyl groups carbon-trans- 2-, dihydro
Piperamide, dihydro pipering etc..Contain volatile oil again, inside have：Piperonal, dihydro carveol, trans-Caryophyllene oxide, cryptone,
Cis-p- dilute -1- alcohol of 2-, cis -2,8- diene -1- alcohol, trans-loose carveol piperitone（pipertone）, sesquialter perfume (or spice) Chinese juniper
Alkene, β-pinone（β-pinone）, l, Isosorbide-5-Nitrae-trimethyl cycloheptyl -2,4- diene -6- ketone, pine tar-l- alkene -5- alcohol（l-terpinen-
5-ol）, -3,8（9）- diene -1- alcohol, N- formylpiperidines, piper cubeba -5,10（15）- diene -4- alcohol, to P-cymene -8- alcohol
Methyl ether etc..With warming spleen and stomach for dispelling cold, lower gas dissolving phlegm, detoxify stomach invigorating the effect of.Cold phlegm dyspepsia is cured mainly, coldness and pain in the epigastrium, gastric disorder causing nausea, vomiting is clearly
Water, diarrhea, cold dysentery, and solve bromatotoxin.
Clinical trial in 2016 36, it is stomach pain, belch, nausea and vomiting, not well typical patient of defecating, is grown up
5-8g is often taken, is taken day 2 times, is treated three weeks, be effective using symptom mitigation, symptom disappearance is healing, symptom is not kept to invalid, disease
Shape, which aggravates to be discontinued, presses invalidation, is evaluated with reference to other test ratings, experimental result is as follows：
| Medicine | Number of cases | Cure | Effectively | It is invalid | Cure rate（%） | Total effective rate（%） |
| This example medicine | 36 | 22 | 6 | 8 | 61.1 | 77.8 |
Calculation formula：Cure rate=（Healing number/sum）× 100%, total effective rate=（Sum-invalid number）/ sum ×
100%.Wherein have no exacerbation of symptoms and midway drug withdrawal person, but there are 6 to cure within two weeks, it is seen then that the markedly fast of this example medicine, always to have
Efficiency maintains an equal level with the 4th kind of embodiment, and cure rate is slightly above the 4th kind of embodiment.
Claims (7)
1. a kind of anaesthetic of regulating gastointestinal, including the bulk drug banksia rose, it is characterised in that：The banksia rose is engaged with fructus amomi, fringed pink,
Its weight is 180-220 parts of the banksia rose, 60-80 parts of fructus amomi, 80-120 parts of fringed pink.
2. the manufacture method of the anaesthetic of regulating gastointestinal as claimed in claim 1, it is characterised in that：The banksia rose, fructus amomi, fringed pink are done
Dry powder mixing processed.
3. the manufacture method of the anaesthetic of regulating gastointestinal according to claim 2, it is characterised in that：The banksia rose and fructus amomi are in liquid
Low-temperature grinding powder is carried out under the participation of nitrogen, fringed pink is propagandized hotly to dry and beats powder and mixed with the powder of the banksia rose and fructus amomi below -10 DEG C
Airtight package afterwards.
4. the anaesthetic of regulating gastointestinal according to claim 3, it is characterised in that：The airtight package is filling capsule or wax
Ball.
5. the anaesthetic of regulating gastointestinal according to claim 1, it is characterised in that：180-220 parts of the banksia rose, fructus amomi 60-
80 parts, 1-3 parts of 80-120 parts of fringed pink and Geniposide, 1-3 parts of deacetylation asperuloside acid methyl esters, Gardenia Yellow 1-5
1-3 parts of part, 1-3 parts of ursolic acid, 2-5 parts of gallic acid, 1-5 parts of Fructus Piperis Longi oil, pipering mixing.
6. the anaesthetic of regulating gastointestinal according to claim 5, it is characterised in that：1-3 parts of the Geniposide, deacetylation car
1-3 parts of leaf grass glucoside acid methyl esters, 1-5 parts of Gardenia Yellow, 1-3 parts of ursolic acid are substituted for 80-120 parts with cape jasmine, described not eat
80-120 parts of replacements of the full pomegranate of 2-5 parts of use of sub- acid, 1-5 parts of the Fructus Piperis Longi oil, 1-3 parts of pipering are dialled 60-80 parts by Bi and replaced
Generation.
7. the anaesthetic of regulating gastointestinal according to claim 5, it is characterised in that：1-3 parts of Geniposide gardenoside 5-8
Part substitutes, and 1-3 parts of deacetylation asperuloside acid methyl esters uses loquat with 7-10 parts of replacements of gardenoside, 1-3 parts of ursolic acid
40-60 parts of replacements of leaf, 2-5 parts of gallic acid dial 40-60 parts with 60-100 parts of replacements of Chinese gall, 1-5 parts of Fructus Piperis Longi oil by Bi
Substitute, 10-20 parts with pepper of 1-3 parts of pipering substitutes.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112691112A (en) * | 2020-01-17 | 2021-04-23 | 成都中医药大学 | New application of asperulosidic acid in promoting gastrointestinal motility |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757278A (en) * | 2008-12-24 | 2010-06-30 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Gastrointestinal disease-treating traditional Chinese medicine composition containing costustoot and preparation method thereof |
| CN102579787A (en) * | 2012-03-19 | 2012-07-18 | 付光春 | Traditional Chinese medicine composition for treating chronic gastritis |
-
2017
- 2017-10-21 CN CN201710988655.8A patent/CN107569645B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757278A (en) * | 2008-12-24 | 2010-06-30 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Gastrointestinal disease-treating traditional Chinese medicine composition containing costustoot and preparation method thereof |
| CN102579787A (en) * | 2012-03-19 | 2012-07-18 | 付光春 | Traditional Chinese medicine composition for treating chronic gastritis |
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| Title |
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| UWYTJSN: "六味木香散研究进展", 《道客巴巴DOC88.COM》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112691112A (en) * | 2020-01-17 | 2021-04-23 | 成都中医药大学 | New application of asperulosidic acid in promoting gastrointestinal motility |
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