CN107567438B - 利鲁唑前药及其用途 - Google Patents

利鲁唑前药及其用途 Download PDF

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CN107567438B
CN107567438B CN201680025374.6A CN201680025374A CN107567438B CN 107567438 B CN107567438 B CN 107567438B CN 201680025374 A CN201680025374 A CN 201680025374A CN 107567438 B CN107567438 B CN 107567438B
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amino
trifluoromethoxy
benzo
thiazol
oxo
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CN107567438A (zh
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J·E·弗罗贝尔
A·B·赖茨
J·C·佩尔蒂埃
G·R·史密斯
H·边
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Biohaven Pharmaceutical Holding Co Ltd
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
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CN201680025374.6A 2015-03-03 2016-02-26 利鲁唑前药及其用途 Active CN107567438B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562127684P 2015-03-03 2015-03-03
US62/127,684 2015-03-03
PCT/US2016/019787 WO2016140879A1 (en) 2015-03-03 2016-02-26 Riluzole prodrugs and their use

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CN107567438A CN107567438A (zh) 2018-01-09
CN107567438B true CN107567438B (zh) 2021-06-29

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US (9) US10639298B2 (enExample)
EP (2) EP3265448B1 (enExample)
JP (2) JP6700293B2 (enExample)
KR (2) KR20230147746A (enExample)
CN (1) CN107567438B (enExample)
AU (3) AU2016226463B2 (enExample)
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US11911369B2 (en) 2015-03-03 2024-02-27 Biohaven Therapeutics Ltd. Prodrugs of riluzole and their method of use
EP3265448B1 (en) 2015-03-03 2021-12-29 Biohaven Pharmaceutical Holding Company Ltd. Riluzole prodrugs and their use
JP2017061430A (ja) * 2015-09-25 2017-03-30 芳男 ▲浜▼田 新規なプロドラッグ
HRP20240617T1 (hr) * 2016-05-20 2024-07-19 Biohaven Therapeutics Ltd. Primjena riluzola, prolijekova riluzola ili analoga riluzola sa imunoterapijama za liječenje raka
US12029731B2 (en) 2016-08-10 2024-07-09 Biohaven Therapeutics Ltd. Acyl benzo[d]thiazol-2-amine and their methods of use
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CN107021959A (zh) * 2017-05-02 2017-08-08 青岛科技大学 一类新型吲哚衍生物及其体外抗肿瘤活性
RS66277B1 (sr) * 2017-11-12 2025-01-31 Biohaven Therapeutics Ltd Primena prolekova riluzola za lečenje ataksija
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BR112022025901A2 (pt) * 2020-06-24 2023-01-10 Biohaven Therapeutics Ltd Composições e métodos para tratar transtorno obsessivo-compulsivo
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WO2022103634A1 (en) 2020-11-16 2022-05-19 Orcosa Inc. Improved use of cannabinoids in the treatment of epilepsy
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WO2022178425A1 (en) * 2021-02-22 2022-08-25 Yale University Targeted bifunctional degraders
KR102785404B1 (ko) 2022-08-19 2025-03-21 부산대학교 산학협력단 리루졸 유도체 및 이를 유효성분으로 포함하는 대장 표적성 염증성 장질환 예방 또는 치료용 조성물
CN114344297B (zh) * 2022-03-01 2024-05-14 暨南大学 利鲁唑在治疗少精症中的应用
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