CN107557180A - A kind of cleaning fluid - Google Patents

A kind of cleaning fluid Download PDF

Info

Publication number
CN107557180A
CN107557180A CN201710878699.5A CN201710878699A CN107557180A CN 107557180 A CN107557180 A CN 107557180A CN 201710878699 A CN201710878699 A CN 201710878699A CN 107557180 A CN107557180 A CN 107557180A
Authority
CN
China
Prior art keywords
parts
cleaning fluid
cleaning
component
defoamer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710878699.5A
Other languages
Chinese (zh)
Inventor
潘高
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chen Yufeng
Original Assignee
Chongqing Zan Long Biological Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chongqing Zan Long Biological Technology Co Ltd filed Critical Chongqing Zan Long Biological Technology Co Ltd
Priority to CN201710878699.5A priority Critical patent/CN107557180A/en
Publication of CN107557180A publication Critical patent/CN107557180A/en
Pending legal-status Critical Current

Links

Landscapes

  • Detergent Compositions (AREA)

Abstract

The invention discloses a kind of cleaning fluid.Cleaning fluid provided by the invention includes:Alkaline hydrated oxide, nonionic surfactant, polyoxyethylene 20 sorbitan monolaurate, zwitterionic surfactant, disodium ethylene diamine tetraacetate, sodium citrate, trishydroxymethylaminomethane, triclosan, defoamer.Cleaning fluid provided by the invention has good cleaning performance, very excellent in particular for the cleaning of emulsion reagent, its cleaning performance;Also very good and cleaning fluid is not easy to crystallize in itself, is not easy to foaming when in use the antibacterial effect of utensil after cleaning fluid provided by the invention cleaning, various biochemical substances can effectively be cleaned, be very suitable for the reaction cup of automatic clinical chemistry analyzer.

Description

A kind of cleaning fluid
Technical field
The present invention relates to a kind of cleaning fluid, and in particular to a kind of cleaning fluid for being used to wash down analytical instrument.
Background technology
Automatic clinical chemistry analyzer is the instrument that certain specified chemical composition in body fluid is measured according to photoelectric colorimetry principle, The body fluid includes serum, blood plasma, urine, cerebrospinal fluid etc., due to its high accuracy, high precision, high flexibility and high efficiency With the characteristics of, substantial amounts of work is carry in clinical labororatory, is one of the instrument that current clinical labororatory is most widely used.
When carrying out clinical labororatory using automatic clinical chemistry analyzer, on the one hand the project kind to be detected is more, phase The external diagnosis reagent complicated answered, another aspect specimen types are various, there is serum, blood plasma, urine, Pleural effusions, cerebrospinal fluid Deng, therefore, cuvette, pipeline etc. be possible to by fibrin, crystallization, grease, dyestuff etc. pollute, breed bacteria, Wu Fabao Demonstrate,prove the plot of instrument, it can be seen that, cleaning performance can directly affect the accuracy of testing result, in order to obtain reliable detection knot Fruit, the purging system of full automatic biochemical apparatus show particularly important.
Preferable automatic clinical chemistry analyzer cleaning agent requirement will not only have preferable cleaning to automatic clinical chemistry analyzer Effect, non-corrosiveness compatible with reaction cup, also require that the influence to instrument flowpath conduit is low, and waste liquid environmental pollution Also it is small.
Most of the automatic biochemistry analyzer, its reaction cup that the country uses belongs to discrete water bath with thermostatic control, such a automatic raw The incubation tank for changing analyzer is generally required with cleaning fluid periodic cleaning, to keep its cleaning, prevents bacterial growth, and reaction cup Need periodically to be soaked with cleaning fluid.But the cleaning fluid source that clinical labororatory uses at present relies primarily on import, but import Reagent cost is higher so that testing cost increase, it adds medical treatment cost indirectly;Domestic cleaning fluid practical effect is owed It is good, especially for detection project of the latex enhancing immune than turbid transmission beam method (i.e. PETIA Latex-enhanced immunoturbidimetric assays), Because the latex contained in reagent is a kind of high molecular polymer, its Main Ingredients and Appearance is polystyrene, and it is easy to be adhered to ratio On color cup, particularly polypropylene material cuvette, situation severe patient, one layer of milky adhesion is formed in the inner surface of cuvette Thing, these milky burs can influence the translucency of cuvette, and then influence absorbance reading, ultimately result in testing result not Accurately.
The cleaning performance in addition, some domestic cleaning agents covet, or even with the addition of excessive surfactant component or strong Acid/highly basic makes that infringement load of the cleaning agent to the flow path system of instrument is very big, and some cleaning agents have knot to improve cleaning performance Situation brilliant, foaming is more, the situation for the carrying pollution that the cleaning agent having is brought into, so many products can not still meet user Demand.
The content of the invention
It is an object of the invention to provide one kind cleaning automatic clinical chemistry analyzer effect is good, antibacterial effect is good, does not crystallize, no Easy to foaming and raw material are the cleaning fluid of environment friendly and pollution-free compound.
The present invention is achieved by the following technical solution:
A kind of cleaning fluid includes following component:Alkaline hydrated oxide, nonionic surfactant, polyoxyethylene sorbitan Alcohol monolaurate, zwitterionic surfactant, disodium ethylene diamine tetraacetate, sodium citrate, trishydroxymethylaminomethane, two Chlorobenzene oxygen chlorophenol, defoamer.Alkaline hydrated oxide is alkali metal hydroxide, such as sodium hydroxide, potassium hydroxide;Polyoxyethylene Sorbitan mono-laurate is Tween-20.
Further, nonionic surfactant described in above-mentioned cleaning fluid is AEO.
Further, zwitterionic surfactant described in above-mentioned cleaning fluid is Cocoamidopropyl betaine.
Further, above-mentioned cleaning fluid includes following parts by weight of component:15-35 parts alkaline hydrated oxide, 0.1-5.5 parts are non- Ionic surface active agent, 0.01-5 parts polyoxyethylene 20 sorbitan monolaurate, 0.01-2.5 amphion surface-actives Agent, 0.1-10 parts disodium ethylene diamine tetraacetate, 0.1-10 parts sodium citrate, 0.1-10 parts trishydroxymethylaminomethane, 0.1-10 Part triclosan, 0.01-2 part defoamers.
It is further preferred that above-mentioned cleaning fluid includes following parts by weight of component:18-30 parts alkaline hydrated oxide, 0.2-5 parts Nonionic surfactant, 0.01-3 parts polyoxyethylene 20 sorbitan monolaurate, 0.01-2 amphion surface-actives Agent, 0.2-8 parts disodium ethylene diamine tetraacetate, 0.2-8 parts sodium citrate, 0.2-8 parts trishydroxymethylaminomethane, 0.1-8 parts two Chlorobenzene oxygen chlorophenol, 0.3-1.8 part defoamers.
Further preferable, above-mentioned cleaning fluid includes following parts by weight of component:25 parts of alkaline hydrated oxides, 3 parts it is non- Ionic surface active agent, 2.5 parts of polyoxyethylene 20 sorbitan monolaurates, 1.5 zwitterionic surfactants, 4 parts of second Edetate disodium, 4 parts of sodium citrates, 4 parts of trishydroxymethylaminomethanes, 4 parts of triclosans, 1 part of defoamer.
Further, defoamer described in above-mentioned cleaning fluid includes following component:Polyether-modified silicon and silicate.Polyethers changes Property silicon is polyether modified silicon oil, i.e. polyether modified silicon oil class defoamer.
Further, defoamer described in above-mentioned cleaning fluid includes following parts by weight of component:The polyether-modified silicon of 1-10 parts, 0.2-2 part silicate.
Further, silicate described in above-mentioned cleaning fluid is alkali silicate.
The present invention has the advantages that:Cleaning fluid provided by the invention has good cleaning performance, especially pin Cleaning to emulsion reagent, its cleaning performance are very excellent;The antibacterial effect of utensil after cleaning fluid cleaning provided by the invention Also very good and cleaning fluid is not easy to crystallize in itself, is not easy to foaming when in use, various biochemical substances can be carried out effectively clear Wash, be very suitable for the reaction cup of automatic clinical chemistry analyzer.
Brief description of the drawings
In order to illustrate more clearly of the technical scheme in the specific embodiment of the invention, embodiment will be retouched below The required accompanying drawing used is briefly described in stating.
Fig. 1 is that the cleaning fluid that the embodiment of the present invention 1 is prepared washs fungistatic effect figure;
Fig. 2 is that commercially available cleaning fluid washs fungistatic effect figure in comparative example of the present invention.
Embodiment
With reference to specific embodiment, the present invention will be further described.The embodiment is only being preferable to carry out for the present invention Example, is not intended to limit the invention, for those skilled in the art, the present invention can have various changes and change Change.Within the spirit and principles of the invention, any modification, equivalent substitution and improvements made etc., should be included in the present invention Protection domain within.
Embodiment 1
Each component is weighed respectively and then prepares cleaning fluid according to following proportioning:
Alkaline hydrated oxide 15g/L, AEO 5g/L, polyoxyethylene 20 sorbitan monolaurate 0.05g/L, Cocoamidopropyl betaine 2g/L, disodium ethylene diamine tetraacetate 8g/L, sodium citrate 0.1g/L, trihydroxy methyl ammonia Methylmethane 10g/L, triclosan 0.2g/L, defoamer 1g/L, surplus are water.
Defoamer according to being prepared as follows:Polyether-modified silicon 2g/L, sodium metasilicate 0.4g/L, surplus are water.
Embodiment 2
Each component is weighed respectively and then prepares cleaning fluid according to following proportioning:
Alkaline hydrated oxide 20g/L, AEO 0.2g/L, polyoxyethylene 20 sorbitan monolaurate 3g/L, Cocoamidopropyl betaine 0.1g/L, disodium ethylene diamine tetraacetate 3g/L, sodium citrate 3g/L, trihydroxy methyl amino Methane 8g/L, triclosan 5g/L, defoamer 2g/L, surplus are water.
Defoamer according to being prepared as follows:Polyether-modified silicon 1g/L, potassium silicate 1g/L, surplus are water.
Embodiment 3
Each component is weighed respectively and then prepares cleaning fluid according to following proportioning:
Alkaline hydrated oxide 20g/L, AEO 3.5g/L, polyoxyethylene 20 sorbitan monolaurate 3g/L, Cocoamidopropyl betaine 1.5g/L, disodium ethylene diamine tetraacetate 4g/L, sodium citrate 4g/L, trihydroxy methyl amino Methane 4g/L, triclosan 4g/L, defoamer 1g/L, surplus are water.
Defoamer according to being prepared as follows:Polyether-modified silicon 5g/L, sodium metasilicate 1g/L, surplus are water.
Comparative example
By the cleaning fluid prepared by embodiment 1 to embodiment 3 be used to cleaning it is of the same race under the conditions of the full-automatic biochemical tested point Analyzer reaction cup, then the automatic clinical chemistry analyzer reaction cup tested under the conditions of of the same race is cleaned with commercially available cleaning fluid, As depicted in figs. 1 and 2, Fig. 1 is the cleaning fluid cleaning that embodiment 1 is prepared to the fungistatic effect comparing result of its reaction cup after cleaning The fungistatic effect of 3 days after reaction cup, Fig. 2 are the fungistatic effects of 3 days after commercially available cleaning fluid cleaning reaction cup, hence it is evident that the visible present invention The cleaning fluid fungistatic effect of offer is significantly better than commercially available prod.
In addition, cleaning fluid prepared by embodiment 1 to 3 also does following check experiment with commercially available cleaning fluid:To by medical biology Gauze after matter pollution is cleaned, and then carries out whiteness test to gauze, and the gauze of used cleaning is polluted by body fluid, its Whiteness value is 40 degree, is cleaned as follows respectively:
Cleaning fluid flushes three times, and then water flushes three times;Blank group is that water rinses six times.
The whiteness value for polluting gauze is brought up to more than 80 degree by cleaning fluid prepared by embodiment 1 to 3, and commercially available cleaning fluid Only its whiteness value is improved to 70 degree, the whiteness value of blank group pollution gauze is unchanged.

Claims (9)

1. a kind of cleaning fluid, it is characterised in that including following component:
Alkaline hydrated oxide, nonionic surfactant, polyoxyethylene 20 sorbitan monolaurate, amphion surface are lived Property agent, disodium ethylene diamine tetraacetate, sodium citrate, trishydroxymethylaminomethane, triclosan, defoamer.
2. cleaning fluid according to claim 1, it is characterised in that
The nonionic surfactant is AEO.
3. cleaning fluid according to claim 1, it is characterised in that
The zwitterionic surfactant is Cocoamidopropyl betaine.
4. cleaning fluid as claimed in any of claims 1 to 3, it is characterised in that including following parts by weight of component:
15-35 parts alkaline hydrated oxide, 0.1-5.5 parts nonionic surfactant, 0.01-5 part polyoxyethylene sorbitans Monolaurate, 0.01-2.5 zwitterionic surfactants, 0.1-10 parts disodium ethylene diamine tetraacetate, 0.1-10 part citric acids Sodium, 0.1-10 parts trishydroxymethylaminomethane, 0.1-10 parts triclosan, 0.01-2 part defoamers.
5. cleaning fluid as claimed in any of claims 1 to 3, it is characterised in that including following parts by weight of component:
18-30 parts alkaline hydrated oxide, 0.2-5 parts nonionic surfactant, 0.01-3 part polyoxyethylene sorbitan lists Laurate, 0.01-2 zwitterionic surfactants, 0.2-8 parts disodium ethylene diamine tetraacetate, 0.2-8 parts sodium citrate, 0.2-8 parts trishydroxymethylaminomethane, 0.1-8 parts triclosan, 0.3-1.8 part defoamers.
6. cleaning fluid as claimed in any of claims 1 to 3, it is characterised in that including following parts by weight of component:
25 parts of alkaline hydrated oxides, 3 portions of nonionic surfactants, 2.5 parts of polyoxyethylene 20 sorbitan monolaurates, 1.5 zwitterionic surfactants, 4 parts of disodium ethylene diamine tetraacetates, 4 parts of sodium citrates, 4 parts of trishydroxymethylaminomethanes, 4 parts Triclosan, 1 part of defoamer.
7. cleaning fluid as claimed in any of claims 1 to 3, it is characterised in that
The defoamer includes following component:Polyether-modified silicon and silicate.
8. cleaning fluid according to claim 7, it is characterised in that
The defoamer includes following parts by weight of component:The polyether-modified silicon of 1-10 parts and 0.2-2 part silicate.
9. cleaning fluid according to claim 8, it is characterised in that
The silicate is alkali silicate.
CN201710878699.5A 2017-09-26 2017-09-26 A kind of cleaning fluid Pending CN107557180A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710878699.5A CN107557180A (en) 2017-09-26 2017-09-26 A kind of cleaning fluid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710878699.5A CN107557180A (en) 2017-09-26 2017-09-26 A kind of cleaning fluid

Publications (1)

Publication Number Publication Date
CN107557180A true CN107557180A (en) 2018-01-09

Family

ID=60981901

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710878699.5A Pending CN107557180A (en) 2017-09-26 2017-09-26 A kind of cleaning fluid

Country Status (1)

Country Link
CN (1) CN107557180A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107402280A (en) * 2017-06-06 2017-11-28 金华市鑫科医药科技有限公司 A kind of cellanalyzer cleaning fluid cleaning rate assay method
CN111205938A (en) * 2020-01-15 2020-05-29 上海太阳生物技术有限公司 Low-foam flushing fluid and application thereof
CN115368975A (en) * 2022-08-03 2022-11-22 吉林基蛋生物科技有限公司 Alkaline cleaning fluid and preparation method thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1548510A (en) * 2003-05-09 2004-11-24 上海捷瑞医用试剂有限公司 Cleaner for hemocyte analyzer and its prepn
CN1566304A (en) * 2003-06-13 2005-01-19 李小平 Full automatic biochemical analyzer cleaning agent
JP4098531B2 (en) * 2002-02-06 2008-06-11 日本電子株式会社 Cell cleaning method for biochemical analyzer
CN102102051A (en) * 2010-12-01 2011-06-22 宁波美康盛德生物科技有限公司 Alkaline cleaning solution applied to automatic biochemical analyzer
CN102304439A (en) * 2011-08-08 2012-01-04 宁波美康盛德生物科技有限公司 Antibacterial cleaning solution for full-automatic biochemistry analyzer
CN104017665A (en) * 2014-06-25 2014-09-03 南通永康检测技术有限公司 Cleaning fluid
CN106947614A (en) * 2017-03-22 2017-07-14 安徽民泰医药科技有限公司 Blood cell analysis cleaning fluid
CN107523435A (en) * 2017-09-20 2017-12-29 北京众驰伟业科技发展有限公司 A kind of coagulo meter cleaning fluid and its application

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4098531B2 (en) * 2002-02-06 2008-06-11 日本電子株式会社 Cell cleaning method for biochemical analyzer
CN1548510A (en) * 2003-05-09 2004-11-24 上海捷瑞医用试剂有限公司 Cleaner for hemocyte analyzer and its prepn
CN1566304A (en) * 2003-06-13 2005-01-19 李小平 Full automatic biochemical analyzer cleaning agent
CN102102051A (en) * 2010-12-01 2011-06-22 宁波美康盛德生物科技有限公司 Alkaline cleaning solution applied to automatic biochemical analyzer
CN102304439A (en) * 2011-08-08 2012-01-04 宁波美康盛德生物科技有限公司 Antibacterial cleaning solution for full-automatic biochemistry analyzer
CN104017665A (en) * 2014-06-25 2014-09-03 南通永康检测技术有限公司 Cleaning fluid
CN106947614A (en) * 2017-03-22 2017-07-14 安徽民泰医药科技有限公司 Blood cell analysis cleaning fluid
CN107523435A (en) * 2017-09-20 2017-12-29 北京众驰伟业科技发展有限公司 A kind of coagulo meter cleaning fluid and its application

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107402280A (en) * 2017-06-06 2017-11-28 金华市鑫科医药科技有限公司 A kind of cellanalyzer cleaning fluid cleaning rate assay method
CN111205938A (en) * 2020-01-15 2020-05-29 上海太阳生物技术有限公司 Low-foam flushing fluid and application thereof
CN111205938B (en) * 2020-01-15 2023-11-24 上海太阳生物技术有限公司 Low-foam flushing fluid and application thereof
CN115368975A (en) * 2022-08-03 2022-11-22 吉林基蛋生物科技有限公司 Alkaline cleaning fluid and preparation method thereof

Similar Documents

Publication Publication Date Title
CN102304439B (en) Antibacterial cleaning solution for full-automatic biochemistry analyzer
CN107557180A (en) A kind of cleaning fluid
CN101470123B (en) Cleaning fluid used for automatic biochemical analyzer
JP3001087B2 (en) Automatic analyzer and method
CN102102051A (en) Alkaline cleaning solution applied to automatic biochemical analyzer
CN103897909A (en) Cleaning solution applied to automatic biochemical analyzer
CN102604754A (en) Biological enzyme cleaning agent and method for preparing same
Bunch et al. A biodegradability test for organic compounds
CN105385512A (en) Low-foam multienzyme cleaning fluid for medical apparatus cleaning and preparation technology thereof
CN104194953A (en) Detergent for cleaning laboratory glassware
CN104017665A (en) Cleaning fluid
CN106319538A (en) Room-temperature metal surface degreaser and preparing method thereof
CN104017667A (en) Antibacterial cleaning solution for instruments
CA2601780C (en) Rapidly detecting and quantifying viable legionella with dip-slide
CN103275818A (en) Acidic cleaner for full-automatic biochemical analyzer and preparation method thereof
CN107502456A (en) A kind of preparation method of solid reagent box cleaning fluid
CN106947614A (en) Blood cell analysis cleaning fluid
CN112924438A (en) Chemiluminescent cleaning buffer solution
CA2025816C (en) Cleaning solution
CN103275819A (en) Water bath cleaning agent used for full-automatic biochemical analyzer and preparation method of water bath cleaning agent
CN109490296B (en) Lipase detection kit and production process
CN1340712A (en) Reagent kit for enzyme-linked immunoassay of rubella, macrocell and monospermous viruses and Toxoplasma antibody
CN110672588A (en) Cleaning reagent for chemiluminescence reaction system and preparation method thereof
CN107603788B (en) Environment-friendly detergent capable of improving trace detection precision and use method thereof
Jurado et al. Comparison and use of methods for the determination of non-ionic surfactants in biodegradation processes

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right

Effective date of registration: 20191225

Address after: 4-1, No.206, zhangjiahuayuan street, Yuzhong District, Chongqing 400000

Applicant after: Chen Yufeng

Address before: 400000 Chongqing Jiulongpo District Road No. 1 No. 6-27-10 of Olympic Sports

Applicant before: Chongqing Zan long biological technology Co. Ltd.

TA01 Transfer of patent application right
RJ01 Rejection of invention patent application after publication

Application publication date: 20180109

RJ01 Rejection of invention patent application after publication