CN102304439A - Antibacterial cleaning solution for full-automatic biochemistry analyzer - Google Patents
Antibacterial cleaning solution for full-automatic biochemistry analyzer Download PDFInfo
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- CN102304439A CN102304439A CN201110225798A CN201110225798A CN102304439A CN 102304439 A CN102304439 A CN 102304439A CN 201110225798 A CN201110225798 A CN 201110225798A CN 201110225798 A CN201110225798 A CN 201110225798A CN 102304439 A CN102304439 A CN 102304439A
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Abstract
The present invention discloses an antibacterial cleaning solution for a full-automatic biochemistry analyzer. The antibacterial cleaning solution is characterized in that: each 1 L of the antibacterial cleaning solution comprises: 0.5-1.0 g of an alkali metal hydroxide, 0.9-1.8 g of an inorganic salt, a non-ionic surfactant, a quaternary ammonium salt cationic surfactant and a foam inhibitor, wherein the volume percentage of the non-ionic surfactant is 0.1-1.0%, the volume percentage of the quaternary ammonium salt cationic surfactant is 0.005-0.02%, and the volume percentage of the foam inhibitor is 0.2-2.0%. The antibacterial cleaning solution provided by the present invention has characteristics of cheap price and low cost, can effectively remove the fibrin, crystal, grease, dyes, latex particles, and other residues easily adhered to the cuvette so as to effectively clean the cuvette, and ensure the accuracy of the test result.
Description
Technical field
The present invention relates to a kind of antibiotic scavenging solution that is used for automatic clinical chemistry analyzer; Specifically; Provide the antibiotic scavenging solution that automatic clinical chemistry analyzer uses when analytical specimen and routine maintenance; Be used to keep the cleaning of cuvette; Reduce the cup differences; Reduce crossed contamination between sample, guarantee the good of instrument running status.
Background technology
Automatic clinical chemistry analyzer is characteristics with its high accuracy, high degree of accuracy, high flexibility and high efficiency, is bearing a large amount of work in clinical labororatory, is that present clinical labororatory uses one of instrument the most widely.In clinical labororatory; One side needs the project of detection many; The corresponding external diagnosis reagent composition that uses is complicated; Specimen types is various on the other hand; Serum, blood plasma, urine, ascites pleural fluid, cerebrospinal fluid etc. are arranged; Therefore; Cuvette, pipeline etc. just might be by pollutions such as scleroproein, crystallization, grease, dyestuffs; Breed bacteria; Can't guarantee the plot of instrument, this shows that cleaning performance can directly influence the accuracy of detected result; In order to obtain reliable result, it is particularly important that the cleaning system of full automatic biochemical apparatus shows.
The automatic biochemistry analyzer of domestic use; Its reaction cup great majority belong to the discrete water bath with thermostatic control, and the hatching tank and generally need use the scavenging solution routine cleaning of this kind automatic biochemistry analyzer is to keep its cleaning; Prevent bacterial growth, and reaction cup need regularly be soaked with scavenging solution.
Antibiotic scavenging solution wherein is mainly used in the reinforcement cleaning of cuvette and the cleaning of reaction incubation slot.
Current clinical laboratory use antibacterial cleaning fluid source is mainly dependent on imports, but the high cost of imported reagents, making the detection of increased costs, so its widespread application is limited; there is domestic antibacterial hand cleaning liquid, but the actual use of effects due to good, especially for latex enhanced turbidimetric immunoassay transmission method (PETIA enhance immune latex turbidimetric method) of the test items, as the reagent contained in a polymer latex, the main ingredients of polystyrene, which is easily adhered to the cuvette, especially polypropylene cuvette, the situation is serious, the inner surface of the cuvette forms a milky white adhesive material, these substances may affect the adhesion milky cuvette light resistance, thereby affecting the absorbance readings, resulting in inaccurate test results.
Summary of the invention
The present invention is directed to the above-mentioned deficiency of prior art; Provide a kind of low price, cost low; And can effectively remove scleroproein, crystallization, grease, dyestuff, latex particle etc. and be easy to adhere to residue on the cuvette, thereby effectively clean cuvette, guarantee the antibiotic scavenging solution that is used for automatic clinical chemistry analyzer of detected result accuracy.
In order to solve the problems of the technologies described above; The technical scheme that the present invention adopts is: a kind of antibiotic scavenging solution of automatic clinical chemistry analyzer that is used for; Contain in the antibiotic scavenging solution of every 1L: contain in the antibiotic scavenging solution of every 1L (water is settled to 1L): the alkali metal hydroxide of 0.5 ~ 1.0g; 0.9 the inorganic salt of ~ 1.8g; Volume is very than the nonionogenic tenside that is 0.1 ~ 1.0%; Volume is very than the quaternary cationics that is 0.005 ~ 0.02%, and volume is very than the suds suppressor that is 0.2 ~ 2.0%.
As preferably; The above-mentioned automatic biochemical that is used for is analyzed the content of antibiotic each composition of scavenging solution and is: contain in the antibiotic scavenging solution of every 1L: the alkali metal hydroxide of 0.75g; 1.35g inorganic salt; Volume is very than the nonionogenic tenside that is 0.5%; Volume is very than the quaternary cationics that is 0.0125%, and volume is very than the suds suppressor that is 1%.
Alkali metal hydroxide of the present invention is sodium hydroxide or potassium hydroxide; Described inorganic salt are water glass or yellow soda ash; Described nonionogenic tenside is that polyoxyethylene glycol is to iso-octyl phenyl ether (Triton X – 100 or title Triton X-100) or polyoxyethylene sorbitan monooleate (Tween-80); Described quaternary cationics is that bromine alkyl dimethyl is for benzene methanamine (bromogeramine or dodecyl dimethyl benzyl ammonium bromide) or dodecyl dimethyl phenoxy group brometo de amonio (domiphen bromide or dodecyl-dimethyl-2-phenoxy group-ethyl brometo de amonio) or tetradecyl lutidine brometo de amonio (Myristylpicolinii Bromide); Described suds suppressor is a Virahol.
Visible by above technical scheme, remove in the antibiotic scavenging solution of automatic biochemistry analyzer provided by the invention and contain alkali metal hydroxide, also contain inorganic salt, nonionogenic tenside, quaternary cationics and suds suppressor.
Wherein, inorganic salt play the effect of a washing assistant in antibiotic scavenging solution, and cost is low, and in the inorganic salt washing assistant, alkaline, inorganic salts is better to the effect of enhanced surface promoting agent decontamination.
Nonionogenic tenside has very strong surfactivity effect, plays a cleaning, emulsive effect in the present invention.
Quaternary cationics has acid-fast alkali-proof, abstersive character, has germicidal action simultaneously, and it has very strong adsorption at bacterium surface, thereby stops breathing and the sugar of bacterium to separate effect, impels protein denaturation, plays sterilization effects.
Suds suppressor preferably adopts Virahol, can eliminate the bubble that produces when reaction cup is rotated effectively.
Advantage of the present invention and beneficial effect:
1. scavenging solution of the present invention is used for the cleaning of automatic biochemistry analyzer; Cleaning performance is good; Cost is low, and (raw material is commercial product; Be easy to get, cheaply); Good stability; Low residue, detected result is accurate and precision good, and the high molecular polymer that especially can solve in the PETIA method of testing adheres to the problem that cuvette forms the oyster white bur.
2. not only cost is low for scavenging solution of the present invention, good stability, and have advantages such as low residue and low crossed contamination.
Embodiment
Further set forth the present invention below in conjunction with specific embodiment, but be not limited to following embodiment.
Embodiment 1
Weigh in the balance and get sodium hydroxide 1.0g; Water glass 1.8g; Then with the water of 500-700mL with sodium hydroxide and water glass dissolving (be sodium hydroxide and water glass the two dissolve with the water of 500-700mL altogether); Again toward wherein slowly adding Triton X-100 (Triton X-100) 10mL; Virahol 20mL; Commercially available 1% bromogeramine (dodecyl dimethyl benzyl ammonium bromide) 20mL; Stirring treats that it fully dissolves; Add water to the 1L mixing at last, promptly obtain the antibiotic scavenging solution of the stable automatic biochemistry analyzer of 1L.
Embodiment 2
Weigh in the balance and get sodium hydroxide 0.5g; Water glass 0.9g; Use the 500-700mL water dissolution; Again toward wherein slowly adding Triton X-100 1mL; Virahol 2mL, commercially available 1% bromogeramine 5mL stirs and treats that it fully dissolves; Add water to the 1L mixing at last, promptly obtain the antibiotic scavenging solution of the stable automatic biochemistry analyzer of 1L.
Embodiment 3
Weigh in the balance and get sodium hydroxide 0.75g; Water glass 1.35g; Use the 500-700mL water dissolution; Again toward wherein slowly adding Triton X-100 5mL; Virahol 10mL, commercially available 1% bromogeramine 12.5mL stirs and treats that it fully dissolves; Add water to the 1L mixing at last, promptly obtain the antibiotic scavenging solution of the stable automatic biochemistry analyzer of 1L.
Embodiment 4
Weigh in the balance and get potassium hydroxide 0.5g; Yellow soda ash 0.9g; Use the 500-700mL water dissolution; Again toward wherein slowly adding Tween-80 1mL; Virahol 2mL, commercially available Myristylpicolinii Bromide powder 0.05g stirs and treats that it fully dissolves; Add water to the 1L mixing at last, promptly obtain the antibiotic scavenging solution of the stable automatic biochemistry analyzer of 1L.
Embodiment 5
Test above-mentioned antibiotic scavenging solution on-line cleaning performance with Hitachi's 7060 automatic biochemistry analyzers, behind the execution wash procedure, get Luo Shi low value Quality Control B
1With high value Quality Control B
2Replication triglyceride level (TG), lipase (LPS), total protein (TP), picric acid method creatinine (CREA), gpt (ALT), β-Qiang Dingsuan projects such as (BHB) are respectively 20 times on Hitachi's 7060 automatic biochemistry analyzers; Again in 20 days to repeatability between doing with a collection of Quality Control batch; Test item is identical; Its repeatability is good, is respectively CV (variation coefficient)≤1.80% and CV≤3.82% with betweenrun precision in batch.
After using scavenging solution of the present invention to clean instrument, the detected result precision of instrument is good, no crossed contamination; Before and after the test, following glass of blank no significant difference of 340nm wavelength has low residue, and the high molecular polymer that especially solves in the PETIA reagent adheres to the problem that cuvette forms the oyster white bur.
Embodiment 6
The antibiotic scavenging solution of preparation is divided into two equal portions, preserved 6 months with 25 ℃ respectively at 4 ℃, outward appearance, pH value have no significant change.Do the contrast experiment with placing 6 months antibiotic scavenging solution of room temperature with the antibiotic scavenging solution of preparation newly, test above-mentioned antibiotic scavenging solution on-line cleaning performance, behind the execution wash procedure, get Luo Shi low value Quality Control B with Hitachi's 7060 automatic biochemistry analyzers
1With high value Quality Control B
2On Hitachi's 7060 automatic biochemistry analyzers projects such as replication TG, LPS, TP, CREA, ALT, β-BHB each 20 times, the result show two groups of results do not have significant difference (
p﹥ 0.05), dependency good (
r﹥ 0.995).Therefore, antibiotic scavenging solution good stability of the present invention is placed and its result of use not to be had obvious influence in 6 months to being less than room temperature.
Claims (7)
1. antibiotic scavenging solution that is used for automatic clinical chemistry analyzer; It is characterized in that: contain in the antibiotic scavenging solution of every 1L: the alkali metal hydroxide of 0.5 ~ 1.0g; 0.9 the inorganic salt of ~ 1.8g; Volume is very than the nonionogenic tenside that is 0.1 ~ 1.0%; Volume is very than the quaternary cationics that is 0.005 ~ 0.02%, and volume is very than the suds suppressor that is 0.2 ~ 2.0%.
2. the antibiotic scavenging solution that is used for automatic clinical chemistry analyzer according to claim 1 is characterized in that: described alkali metal hydroxide is sodium hydroxide or potassium hydroxide.
3. the antibiotic scavenging solution that is used for automatic clinical chemistry analyzer according to claim 1 is characterized in that: described inorganic salt are water glass or yellow soda ash.
4. the antibiotic scavenging solution that is used for automatic clinical chemistry analyzer according to claim 1 is characterized in that: described nonionogenic tenside is that polyoxyethylene glycol is to iso-octyl phenyl ether or polyoxyethylene sorbitan monooleate.
5. the antibiotic scavenging solution that is used for automatic clinical chemistry analyzer according to claim 1 is characterized in that: described quaternary cationics is dodecyl dimethyl benzyl ammonium bromide or dodecyl dimethyl phenoxy group brometo de amonio or tetradecyl lutidine brometo de amonio.
6. the antibiotic scavenging solution that is used for automatic clinical chemistry analyzer according to claim 1 is characterized in that: described suds suppressor is a Virahol.
7. according to the described antibiotic scavenging solution that is used for automatic clinical chemistry analyzer of the arbitrary right of claim 1 ~ 6; It is characterized in that: contain in the antibiotic scavenging solution of every 1L: the alkali metal hydroxide of 0.75g; 1.35g inorganic salt; Volume is very than the nonionogenic tenside that is 0.5%; Volume is very than the quaternary cationics that is 0.0125%, and volume is very than the suds suppressor that is 1%.
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| CN 201110225798 CN102304439B (en) | 2011-08-08 | 2011-08-08 | Antibacterial cleaning solution for full-automatic biochemistry analyzer |
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| CN 201110225798 CN102304439B (en) | 2011-08-08 | 2011-08-08 | Antibacterial cleaning solution for full-automatic biochemistry analyzer |
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| CN102304439A true CN102304439A (en) | 2012-01-04 |
| CN102304439B CN102304439B (en) | 2013-04-17 |
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103412088A (en) * | 2013-07-26 | 2013-11-27 | 北京控制工程研究所 | Chemical test method for bipropellant thruster after thermal standard cleaning |
| CN103897909A (en) * | 2012-12-28 | 2014-07-02 | 上海复星医药（集团）股份有限公司 | Cleaning solution applied to automatic biochemical analyzer |
| CN104017667A (en) * | 2014-06-25 | 2014-09-03 | 南通永康检测技术有限公司 | Antibacterial cleaning solution for instruments |
| CN105754733A (en) * | 2016-02-04 | 2016-07-13 | 广州科方生物技术有限公司 | Cleaning solution for chemiluminescence immunity analyzer |
| CN106726705A (en) * | 2017-01-04 | 2017-05-31 | 长江医学科学院 | A kind of skin cleansing liquid and preparation method thereof |
| CN106753876A (en) * | 2015-11-23 | 2017-05-31 | 迈瑞南京生物技术有限公司 | Bottle-washing agent |
| CN107034054A (en) * | 2017-04-01 | 2017-08-11 | 合肥迪安医学检验所有限公司 | A kind of biochemical instruments cuvette cleaning fluid |
| CN107365639A (en) * | 2017-03-31 | 2017-11-21 | 上海艾瑞德生物科技有限公司 | A kind of collaurum platform cleaning fluid |
| CN107557180A (en) * | 2017-09-26 | 2018-01-09 | 重庆赞龙生物科技有限公司 | A kind of cleaning fluid |
| CN107881021A (en) * | 2017-11-23 | 2018-04-06 | 中山市创艺生化工程有限公司 | A kind of thermostat cleaning fluid and preparation method thereof |
| CN108004038A (en) * | 2017-11-23 | 2018-05-08 | 中山市创艺生化工程有限公司 | A kind of alkaline cleaning fluid and preparation method thereof |
| CN109022169A (en) * | 2018-05-21 | 2018-12-18 | 苏州佑君环境科技有限公司 | A kind of chemiluminescence instrument pipeline composite cleaning liquid and preparation method thereof |
| CN115368975A (en) * | 2022-08-03 | 2022-11-22 | 吉林基蛋生物科技有限公司 | Alkaline cleaning fluid and preparation method thereof |
| CN116286205A (en) * | 2022-12-23 | 2023-06-23 | 浙江鑫科医疗科技有限公司 | Tripropylamine cleaning buffer solution matched with Rogowski Cobas e801 chemiluminescent immunoassay analyzer and preparation method thereof |
| CN116286205B (en) * | 2022-12-23 | 2024-04-19 | 浙江鑫科医疗科技有限公司 | Tripropylamine buffer solution matched with Luo Cobas e801 chemiluminescent immunoassay analyzer and preparation method thereof |
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Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103897909A (en) * | 2012-12-28 | 2014-07-02 | 上海复星医药（集团）股份有限公司 | Cleaning solution applied to automatic biochemical analyzer |
| CN103412088A (en) * | 2013-07-26 | 2013-11-27 | 北京控制工程研究所 | Chemical test method for bipropellant thruster after thermal standard cleaning |
| CN103412088B (en) * | 2013-07-26 | 2015-05-27 | 北京控制工程研究所 | Chemical test method for bipropellant thruster after thermal standard cleaning |
| CN104017667A (en) * | 2014-06-25 | 2014-09-03 | 南通永康检测技术有限公司 | Antibacterial cleaning solution for instruments |
| CN106753876A (en) * | 2015-11-23 | 2017-05-31 | 迈瑞南京生物技术有限公司 | Bottle-washing agent |
| CN105754733A (en) * | 2016-02-04 | 2016-07-13 | 广州科方生物技术有限公司 | Cleaning solution for chemiluminescence immunity analyzer |
| CN106726705A (en) * | 2017-01-04 | 2017-05-31 | 长江医学科学院 | A kind of skin cleansing liquid and preparation method thereof |
| CN107365639A (en) * | 2017-03-31 | 2017-11-21 | 上海艾瑞德生物科技有限公司 | A kind of collaurum platform cleaning fluid |
| CN107365639B (en) * | 2017-03-31 | 2020-04-24 | 上海艾瑞德生物科技有限公司 | Colloidal gold platform cleaning solution |
| CN107034054A (en) * | 2017-04-01 | 2017-08-11 | 合肥迪安医学检验所有限公司 | A kind of biochemical instruments cuvette cleaning fluid |
| CN107557180A (en) * | 2017-09-26 | 2018-01-09 | 重庆赞龙生物科技有限公司 | A kind of cleaning fluid |
| CN107881021A (en) * | 2017-11-23 | 2018-04-06 | 中山市创艺生化工程有限公司 | A kind of thermostat cleaning fluid and preparation method thereof |
| CN108004038A (en) * | 2017-11-23 | 2018-05-08 | 中山市创艺生化工程有限公司 | A kind of alkaline cleaning fluid and preparation method thereof |
| CN108004038B (en) * | 2017-11-23 | 2020-12-25 | 中山市创艺生化工程有限公司 | Alkaline cleaning fluid and preparation method thereof |
| CN109022169A (en) * | 2018-05-21 | 2018-12-18 | 苏州佑君环境科技有限公司 | A kind of chemiluminescence instrument pipeline composite cleaning liquid and preparation method thereof |
| CN115368975A (en) * | 2022-08-03 | 2022-11-22 | 吉林基蛋生物科技有限公司 | Alkaline cleaning fluid and preparation method thereof |
| CN116286205A (en) * | 2022-12-23 | 2023-06-23 | 浙江鑫科医疗科技有限公司 | Tripropylamine cleaning buffer solution matched with Rogowski Cobas e801 chemiluminescent immunoassay analyzer and preparation method thereof |
| CN116286205B (en) * | 2022-12-23 | 2024-04-19 | 浙江鑫科医疗科技有限公司 | Tripropylamine buffer solution matched with Luo Cobas e801 chemiluminescent immunoassay analyzer and preparation method thereof |
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