CN107551866B - Quick mixing device for adjuvant and antigen - Google Patents
Quick mixing device for adjuvant and antigen Download PDFInfo
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- CN107551866B CN107551866B CN201710765237.2A CN201710765237A CN107551866B CN 107551866 B CN107551866 B CN 107551866B CN 201710765237 A CN201710765237 A CN 201710765237A CN 107551866 B CN107551866 B CN 107551866B
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to a rapid mixing device for an adjuvant and an antigen. In order to fill the blank in the prior art, the rapid mixing device for the adjuvant and the antigen comprises an injector, and further comprises a mixer, wherein the mixer comprises an open cup and a mixing cup cover mechanism, the mixing cup cover mechanism comprises a cover cap, an upper stirring cage, a lower stirring cage and a fixed driving frame, a vertical shaft is fixed at the center of the cover cap, the upper stirring cage comprises an upper disc and a plurality of vertical stirring rods, an upper sun gear is further arranged on the lower surface of the upper disc, the lower stirring cage comprises a lower disc and a plurality of groups of vertical stirring rods, the upper sun gear and the lower sun gear are in projection superposition on the same horizontal plane, the fixed driving frame at least comprises two meteor gears, a radial horizontal fixed shaft and a driving motor, the meteor gears are meshed with the upper sun gear and the lower sun gear at the same time, and one meteor gear is driven by the driving motor, and a liquid injection hole is formed in the vertical shaft. The invention has scientific design, simple operation, convenience and labor saving, and is suitable for preparing various water-in-oil and oil-in-water emulsifiers.
Description
Technical Field
The invention relates to a rapid mixing device for an adjuvant and an antigen.
Background
Freund's adjuvant is the most commonly used adjuvant in animal experiments today and is classified into incomplete Freund's adjuvant and complete Freund's adjuvant. The incomplete Freund's adjuvant is formed by mixing liquid paraffin and lanolin, and the composition ratio is 1-5: 1, which may be as desired, is generally 2:1.
the incomplete adjuvant is Bacillus Calmette-Guerin vaccine (final concentration is 3-20 mg/ml) or dead mycobacterium tuberculosis, namely Freund's complete adjuvant (CFA). Emulsification is typically performed with 1/2 volume FCA plus 1/2 volume antigen for the first injection, with incomplete or no adjuvant for the second or third injection. If no adjuvant is added, the antigen amount is increased by 10-20 times. The preparation method comprises the following steps: placing lanolin and paraffin oil in a container according to a certain proportion, uniformly mixing them by using ultrasonic wave, high-pressure sterilizing, and storing at 5 deg.C for later use.
Before immunization of animals, freund's adjuvant and antigen are mixed according to a certain proportion, and the volume ratio of the adjuvant to the antigen is generally 1:1, preparing into a water-in-oil emulsion. Because SDS is easily emulsified into water-in-oil antigen emulsion complex, it must be kept emulsified when injected into animals. Emulsification of the adjuvant with the antigen can be performed as follows:
(1) Grinding method: heating the adjuvant, taking a proper amount of the adjuvant, putting the adjuvant into a sterile glass mortar, slowly dripping an equal volume of antigen solution after the adjuvant is cooled, and grinding the adjuvant in the same direction while dripping the antigen solution, wherein the speed of dripping the antigen is slow. After all the antigen is added, grinding is continued for a period of time to make the antigen become milky viscous water-in-oil emulsion. The method is suitable for preparing a large amount of adjuvant antigens, and has the defect of large amount of emulsion adhered to the wall of a mortar and large antigen loss.
(2) Syringe mixing method: the equivalent Freund's adjuvant and antigen solution are respectively sucked into two syringes, the two syringes are connected by a thin rubber tube, the air is carefully discharged, and then the syringes are alternately pushed until a viscous emulsion is formed. The method has the advantages of easy aseptic operation, less antigen loss, and suitability for preparing a small amount of antigen emulsion. However, it is difficult to emulsify completely, individual antigens are not pushed at all by plastic syringes, and leakage occurs by glass syringes.
The invention of China, published in 2012, 09 and 26U and with publication number CN 202447017U, discloses a novel device for mixing an immunoadjuvant and an antigen, which is characterized in that: the device comprises a mixing body part, a scale body part and a plunger which is suitable for manual force to travel in the device, wherein an elastic sealing element is arranged in an inner cavity of the mixing body part, a perforation is arranged in the middle of the elastic sealing element, and the plunger penetrates through the perforation. This device is simply a syringe.
(3) Ultrasonic: laboratory conditions, such as the presence of an ultrasonic disruptor, must control the frequency and time of the ultrasound, which tends to excite some of the free radicals, unknown damage to the antigen. The emulsification method is determined according to antigen and need.
The prior art lacks a rapid mixing device for adjuvant and antigen, which is simple and convenient to use, labor-saving and high in efficiency.
Disclosure of Invention
The invention aims to solve the technical problem of filling the blank in the prior art and provides a rapid mixing device for an adjuvant and an antigen, which is convenient to assemble and disassemble and does not need to punch holes on the ground.
For solving the technical problem, the rapid mixing device for the adjuvant and the antigen comprises an injector, wherein the injector comprises a needle cylinder and a push rod, a nozzle is arranged at the front end of the needle cylinder, the rear end of the needle cylinder is opened, the front part of the push rod stretches into the inner wall of the needle cylinder, and the push rod or the front end of the push rod is in liquid seal with the inner wall of the needle cylinder, and the rapid mixing device is characterized in that: the mixer comprises an open cup and a mixing cup cover mechanism, wherein the mixing cup cover mechanism comprises a cover, an upper stirring cage, a lower stirring cage and a fixed driving frame, a vertical shaft is fixed at the center of the cover, the upper stirring cage comprises an upper disc and a plurality of vertical stirring rods, an axle center hole is formed in the center of the upper disc and sleeved on the vertical shaft through the axle center hole, the vertical stirring rods are uniformly fixed on the lower surface of the upper disc around the axle center hole and are close to the outer edge of the upper disc, an upper sun gear is further arranged on the lower surface of the upper disc, the lower stirring cage comprises a lower disc and a plurality of groups of vertical stirring rods, the center hole is formed in the center of the lower disc and sleeved on the vertical shaft through the axle center hole, each group of vertical stirring rods are uniformly fixed on the lower surface of the lower disc in the radial direction, each group of vertical stirring rods are uniformly distributed around the axle center hole, a lower sun gear is further arranged on the upper surface of the lower disc, the axle center of the upper disc and the lower sun gear is overlapped with the vertical shaft, the upper disc and the vertical stirring rods form an upper stirring cage, the lower disc and the vertical stirring cage and the vertical stirring rods are adjacent to the outer edge of the upper disc, the lower disc and the lower stirring cage form a rotor, and the upper stirring cage and a driving sun gear are meshed with at least two fluid-jet motor and a driving sun gear respectively, and a driving sun is meshed between the upper stirring cage and at least a lower stirring cage.
During installation, a quantitative adjuvant is poured into the open cup, then the cover is covered on the open cup, and the vertical stirring rods of the upper stirring cage and the lower stirring cage extend into the adjuvant. Then the driving motor is started, the fixed driving frame is fixed, and the meteor gear drives the upper stirring cage and the lower stirring cage to rotate in the clockwise direction and the reverse time direction respectively. Then sucking the antigen solution with a syringe in a predetermined proportion, and finally inserting a nozzle of the syringe into the liquid injection hole, and injecting the adjuvant into the open cup from the liquid injection hole. The design is that the upper stirring cage and the lower stirring cage shear and stir the antigen solution and the adjuvant at high speed, so that the two forms the water-in-oil emulsifier, thereby saving labor and being convenient.
As optimization, the horizontal cross sections of the vertical stirring rods are rectangular, and the long sides of the rectangular horizontal cross sections of the vertical stirring rods on the upper disc form an included angle a with the tangential direction when the long sides rotate; the long side of the rectangular horizontal cross section of the vertical stirring rod on the lower disc forms an included angle b with the tangential direction when the vertical stirring rod rotates, and a is more than or equal to 60 degrees and less than or equal to 90 degrees, and b is more than or equal to 45 degrees and less than or equal to 80 degrees. By the design, the stirring and emulsifying effects are better.
The rapid mixing device for the adjuvant and the antigen creatively takes the meteor gear in the meteor gear mechanism as a fixed part, takes the sun gear as a rotating part, drives the motor to rotate clockwise and anticlockwise respectively through the meteor gear, simultaneously drives the upper sun gear and the lower sun gear, and the vertical stirring rod on the upper stirring cage and the lower stirring cage to shear and stir the antigen solution and the adjuvant at high speed so as to rapidly form the water-in-oil emulsifier.
Drawings
The rapid mixing device of the adjuvant and the antigen is further described below with reference to the accompanying drawings:
FIG. 1 is a schematic cross-sectional view of a first embodiment of a rapid mixing device for an adjuvant and an antigen (with parts cut along a plane passing through the axis);
FIG. 2 is a schematic bottom view of the upper mixing cage of FIG. 1;
FIG. 3 is a schematic bottom view of the lower mixing cage of FIG. 1;
FIG. 4 is a schematic view from above of the upper and lower mixing cages of FIG. 1 in a mixing and shearing mode;
fig. 5 is a schematic view showing the stirring and shearing of the upper and lower stirring cages of the second embodiment of the rapid mixing device for the adjuvant and the antigen.
In the figure: 1 is an open cup, 2 is a cover, 3 is a vertical shaft, 4 is an upper disc, 5 is a vertical stirring rod, 61 is an axle center hole of the upper disc 4, 62 is an axle center hole of the lower disc 8, 7 is an upper sun gear, 8 is a lower disc, 9 is a lower sun gear, 10 is a meteor gear, 11 is a driving motor, 12 is a liquid injection hole, 13 is a radial horizontal fixed shaft, 14 is an annular sealing gasket, 15 is a handle on the cover, 16 is an adjuvant, and a is an included angle between the long side of a rectangular horizontal cross section of the vertical stirring rod 5 on the upper disc 4 and a tangential direction when the vertical stirring rod rotates; b is the angle between the long side of the rectangular horizontal cross section of the vertical stirring rod 5 on the lower disc 8 and the tangential direction when it rotates.
Detailed Description
Embodiment one: as shown in fig. 1-4, the rapid mixing device for adjuvant and antigen comprises an injector (not shown in the drawings), the injector comprises a syringe and a push rod, the front end of the syringe is provided with a nozzle, the rear end of the syringe is opened, the front part of the push rod extends into the inner wall of the syringe, and the push rod or the front end of the push rod is in liquid seal with the inner wall of the syringe, and the rapid mixing device is characterized in that: the mixer further comprises a mixer, the mixer comprises an open cup 1 and a mixing cup cover mechanism, the mixing cup cover mechanism comprises a cover 2, an upper stirring cage, a lower stirring cage and a fixed driving frame, a vertical shaft 3 is fixed at the center of the cover 2, the upper stirring cage comprises an upper disc 4 and a plurality of vertical stirring rods 5, an axle center hole 61 is formed in the center of the upper disc 4 and sleeved on the vertical shaft 3 through the axle center hole 61, the vertical stirring rods 5 are uniformly fixed on the lower surface of the upper disc 4 around the axle center hole 61 and are close to the outer edge of the upper disc 4, an upper sun gear 7 is further arranged on the lower surface of the upper disc 4, the lower stirring cage comprises a lower disc 8 and a plurality of groups of vertical stirring rods 5, the center of the lower disc is provided with an axle center hole 62 and sleeved on the vertical shaft 3 through the axle center hole 62, each group of vertical stirring rods 5 are uniformly distributed on the lower disc 8 in the radial direction, a lower sun gear 9 is further arranged on the upper surface of the lower disc 8, upper sun gear 7 and the lower sun gear 9 are uniformly fixed on the lower disc 4 around the axle center hole 61, a vertical shaft 10 is meshed with at least two vertical stirring cages 10, and a vertical stirring cage is formed by at least two vertical shafts 10 and a vertical stirring cage, and a vertical stirring cage is simultaneously meshed with at least two vertical stirring cage shafts 10 and a vertical stirring cage 10, and a vertical stirring cage is formed between the upper shaft 10 and a vertical stirring cage.
The fixed driving frame further comprises a radial horizontal fixed shaft 13, the radial horizontal fixed shaft 13 is directly or indirectly fixed on the vertical shaft 3, and a meteor gear 10 is sleeved on the radial horizontal fixed shaft 13 and can rotate around the radial horizontal fixed shaft 13 to be a driven meteor gear. A meteor gear 10 is fixed on the output shaft of the driving motor 11, the driving motor 11 is directly or indirectly fixed on the vertical shaft 3, the axis line of the output shaft coincides with a radial line of the vertical shaft 3, and the meteor gear is driven by the driving motor 11 to be an active meteor gear.
The lower end of the liquid injection hole 12 is directed between the upper stirring cage and the lower stirring cage, and the top of the liquid injection hole 12 is enlarged and embedded with an annular sealing gasket 14.
The prepared emulsifier can be used only after identification, and the identification method is to drop the emulsifier into cold water, if the emulsifier is kept intact and not dispersed, the emulsifier floats on the water surface in a drop shape, namely the emulsifier is completely emulsified, and the emulsifier is a qualified water-in-oil agent.
Embodiment two: as shown in fig. 5, the horizontal cross sections of the vertical stirring rods 5 are rectangular, and the long sides of the rectangular horizontal cross sections of the vertical stirring rods 5 on the upper disc 4 form an included angle a with the tangential direction when the long sides rotate; the long side of the rectangular horizontal cross section of the vertical stirring rod 5 on the lower disc 8 forms an included angle b with the tangential direction when the vertical stirring rod rotates, and a is more than or equal to 60 degrees and less than or equal to 90 degrees, and b is more than or equal to 45 degrees and less than or equal to 80 degrees. The rest of the structure is as described in the first embodiment.
Claims (3)
1. The utility model provides a quick mixing arrangement of adjuvant and antigen, includes the syringe, and this syringe includes cylinder and push rod, and the cylinder front end is equipped with the nozzle, cylinder rear end opening, the push rod front portion stretches into in the cylinder inner wall, liquid seal between push rod or push rod front end and the cylinder inner wall, its characterized in that: the mixer also comprises a mixer, the mixer comprises an open cup and a mixing cup cover mechanism, wherein the mixing cup cover mechanism comprises a cover cap, an upper stirring cage, a lower stirring cage and a fixed driving frame, a vertical shaft is fixed at the center of the cover cap, the upper stirring cage comprises an upper disc and a plurality of vertical stirring rods, an axle center hole is formed in the center of the upper disc and sleeved on the vertical shaft through the axle center hole, the vertical stirring rods are uniformly fixed on the lower surface of the upper disc around the axle center hole and are close to the outer edge of the upper disc, an upper sun gear is further arranged on the lower surface of the upper disc, the lower stirring cage comprises a lower disc and a plurality of groups of vertical stirring rods, the center of the lower disc is provided with an axle center hole and sleeved on the vertical shaft through the axle center hole, each group of vertical stirring rods are uniformly fixed on the lower surface of the lower disc along the radial direction, and each group of vertical stirring rods are uniformly distributed around the axle center hole, the upper surface of the lower disc is also provided with a lower sun gear, the projections of the upper sun gear and the lower sun gear on the same horizontal plane are overlapped, the axes of the upper disc and the vertical stirring rods are overlapped with the axes of the vertical shafts, the upper disc and the vertical stirring rods form an upper stirring cage, the lower stirring cage covers the lower stirring cage, the fixed driving frame at least comprises two meteor gears and a driving motor, the two meteor gears are respectively clamped between the upper sun gear and the lower sun gear and meshed with the upper sun gear and the lower sun gear, at least one meteor gear is driven by the driving motor, the vertical shaft is provided with a liquid injection hole, the fixed driving frame also comprises a radial horizontal fixed shaft, the radial horizontal fixed shaft is directly or indirectly fixed on the vertical shaft, one meteor gear is sleeved on the radial horizontal fixed shaft and can rotate around the radial horizontal fixed shaft, one meteor gear is fixed on the output shaft of the driving motor and is driven by the driving motor, and the driving motor is directly or indirectly fixed on the vertical shaft, and the axis line of the output shaft of the driving motor is coincident with a radial line of the vertical shaft.
2. The rapid mixing device of an adjuvant and an antigen according to claim 1, wherein: the horizontal cross section of the vertical stirring rod is rectangular, and the long side of the rectangular horizontal cross section of the vertical stirring rod on the upper disc forms an included angle a with the tangential direction when the long side rotates; the long side of the rectangular horizontal cross section of the vertical stirring rod on the lower disc forms an included angle b with the tangential direction when the vertical stirring rod rotates, and the angle a is less than or equal to 60 degrees and less than or equal to 90 degrees, and the angle b is less than or equal to 45 degrees and less than or equal to 80 degrees.
3. The rapid mixing device of an adjuvant and an antigen according to claim 1 or 2, characterized in that: the lower end of the liquid injection hole is directed between the upper stirring cage and the lower stirring cage, and the top of the liquid injection hole is enlarged and embedded with an annular sealing gasket.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710765237.2A CN107551866B (en) | 2017-08-30 | 2017-08-30 | Quick mixing device for adjuvant and antigen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710765237.2A CN107551866B (en) | 2017-08-30 | 2017-08-30 | Quick mixing device for adjuvant and antigen |
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| Publication Number | Publication Date |
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| CN107551866A CN107551866A (en) | 2018-01-09 |
| CN107551866B true CN107551866B (en) | 2023-08-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710765237.2A Active CN107551866B (en) | 2017-08-30 | 2017-08-30 | Quick mixing device for adjuvant and antigen |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116099403B (en) * | 2023-04-10 | 2023-07-11 | 赛尔托马斯生物科技(成都)有限公司 | Mixer for antigen and adjuvant and mixing device |
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