CN107540953B - Polypropylene resin composition for medical syringe and preparation method thereof - Google Patents
Polypropylene resin composition for medical syringe and preparation method thereof Download PDFInfo
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- CN107540953B CN107540953B CN201610489861.XA CN201610489861A CN107540953B CN 107540953 B CN107540953 B CN 107540953B CN 201610489861 A CN201610489861 A CN 201610489861A CN 107540953 B CN107540953 B CN 107540953B
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Abstract
The invention belongs to the technical field of high polymer material processing, and particularly relates to a polypropylene resin composition for a medical injector and a preparation method thereof. The polypropylene resin composition for the medical injector is prepared from the following raw materials: homopolymerized PP, random copolymerized PP, impact-resistant copolymerized transparent PP, an antioxidant, an acid acceptor, a lubricant and a nucleating agent. The invention obtains the transparent polypropylene composition with high rigidity and toughness balance through the screening of three polypropylene base resins and the application of an auxiliary agent system. The composition can meet the requirements of medical standards, is used for producing medical injectors, and can also be used for producing transparent food boxes, storage boxes and other transparent products by injection molding. Because of higher rigidity and toughness balance and transparency, the quality and durability of the product are improved.
Description
Technical Field
The invention belongs to the technical field of high polymer material processing, and particularly relates to a polypropylene resin composition for a medical injector and a preparation method thereof.
Background
Currently, polypropylene is the primary raw material for the production of disposable medical syringes. The polypropylene for medical injectors meets the requirements of YY/T0242-2007 on the physical and mechanical properties, biological properties, chemical properties and the like of polypropylene, and the prior art can produce polypropylene resin meeting the above standard requirements, but in the actual use of producing medical injectors, the prior polypropylene resin has the problem of insufficient toughness, which is shown in the following: the produced syringe has a phenomenon of breakage during transportation and use, and the phenomenon is more serious particularly at low temperature, which affects normal use. In order to solve the problem of insufficient toughness, syringe manufacturers generally add toughening materials such as POP, POE, SEBS, metallocene PE, propylene-based elastomer and the like into polypropylene for toughening, but the introduced toughening agent reduces the rigidity and transparency of the material, and meanwhile, another non-PP material brings very unfavorable factors for controlling the sanitation of syringe products.
Based on the above problems, the development of a new polypropylene-based composition is urgent to meet the requirements of medical injectors for rigidity, toughness, transparency and medical standards.
Disclosure of Invention
The invention aims to provide a polypropylene resin composition for a medical injector, which has higher rigidity and toughness balance and transparency, and improves the quality and durability of products; the invention also provides a preparation method of the polypropylene resin composition for the medical injector, which is scientific, reasonable, simple and feasible.
The polypropylene resin composition for the medical injector is prepared from the following raw materials in parts by weight:
the MFR of the homopolymerized PP is 10-60g/10min, and the flexural modulus is more than 1600 MPa.
The random copolymerization PP is an ethylene-propylene random copolymer or a propylene-butylene random copolymer, the content of a comonomer is 3-3.5%, the MFR is 8-40g/10min, and the haze of a 1mm sample is below 10%.
The MFR of the impact-resistant copolymerized transparent PP is 8-30g/10min, the ethylene content is 4-6%, and the impact of a simple beam notch is realizedStrength 10kJ/m2The haze of the 1mm sample sheet is 13% or less.
The antioxidant is one of hindered phenol antioxidant, phosphite antioxidant or composite antioxidant. The amount is 0.1 to 0.3 part, preferably 0.2 part.
The composite antioxidant is a composite of an antioxidant 1010 and an antioxidant 168, and the mass ratio of the antioxidant 1010 to the antioxidant 168 is 1: 1.
The acid scavenger is stearate, including calcium stearate, zinc stearate, sodium stearate, etc., preferably calcium stearate, abbreviated as Cast.
The lubricant is one of glyceryl monostearate, fatty acid metal salt, fatty amide or wax, preferably glyceryl monostearate, and has a chemical name of glyceryl monostearate, namely glyceryl monostearate GMS for short.
The nucleating agent is phosphate nucleating agent or sorbitol nucleating agent, and the using amount is 0.3-0.4 parts, preferably 0.35 parts.
The preparation method of the polypropylene resin composition for the medical injector comprises the steps of weighing raw materials, stirring and mixing, and extruding and granulating by a double screw.
Compared with the prior art, the invention has the following beneficial effects:
the invention obtains the transparent polypropylene composition with high rigidity and toughness balance through the screening of three polypropylene base resins and the application of an auxiliary agent system. The composition can meet the requirements of medical standards, is used for producing medical injectors, and can also be used for producing transparent food boxes, storage boxes and other transparent products by injection molding. Because of higher rigidity and toughness balance and transparency, the quality and durability of the product are improved.
Detailed Description
The present invention is further described below with reference to examples.
The antioxidant used in the following examples and comparative examples was 1010, 168 parts of a 1:1 compounded agent in an amount of 0.2 parts. The nucleating agent is sorbitol nucleating agent, and the using amount is 0.35 part. The acid absorbent is calcium stearate, and the dosage is 0.05 part. The lubricant used was glyceryl monostearate, used in an amount of 0.05 parts.
The composition and performance of the starting materials of examples 1-3 are shown in Table 1.
The preparation method of the composition comprises the following steps: the auxiliary agent and the resin in the table are weighed according to the proportion, stirred and mixed, and then extruded and granulated by a double screw to obtain the composition.
Performance test methods in the table:
the melt Mass Flow Rate (MFR) was carried out in accordance with GB/T3682-2000;
the impact strength of the notch of the simply supported beam is tested according to GB/T1043.1-2008;
the flexural modulus was carried out according to GB/T9341-;
rockwell hardness was performed according to GB/T3398.2-2008;
haze was performed according to GB/T2410-;
the separation force was performed according to GB/T1962-2001.
Table 1 examples 1-3 raw material compositions and properties
Table 2 examples 4-6 raw material compositions and properties
As can be seen from examples 1 to 6, the compositions prepared according to the present invention all use polypropylene as a base resin, ensuring the uniqueness and hygiene of the product in terms of the molecular structure composition. The prepared composition has good rigidity and toughness balance, transparency, hardness and the like, so that the requirements on the transparency appearance, the separation force test, the mechanical property and the like of the syringe product are ensured.
The comparison is shown in tables 3 and 4, wherein the polypropylene used is the same as in the examples.
TABLE 3 comparative examples 1-3 raw material compositions and Properties
TABLE 4 comparative examples 4-6 raw material compositions and Properties
As can be seen from comparative examples 1 to 6, the compositions prepared in the comparative examples have defects in toughness, rigidity, hardness, transparency, separating force, etc.
Claims (7)
1. The polypropylene resin composition for the medical injector is characterized by being prepared from the following raw materials in parts by weight:
the MFR of the homopolymerized PP is 10-60g/10min, and the flexural modulus is more than 1600 MPa;
the random copolymerization PP is an ethylene-propylene random copolymer or a propylene-butylene random copolymer, the content of a comonomer is 3-3.5%, the MFR is 8-40g/10min, and the haze of a 1mm sample piece is less than 10%;
the MFR of the impact-resistant copolymerized transparent PP is 8-30g/10min, the ethylene content is 4-6%, and the impact strength of a simple beam notch is 10kJ/m2The haze of the 1mm sample sheet is 13% or less.
2. The polypropylene resin composition for medical syringes according to claim 1, wherein the antioxidant is one of hindered phenolic antioxidant, phosphite antioxidant or complex antioxidant.
3. The polypropylene resin composition for medical syringes according to claim 2, wherein the complex antioxidant is a complex of antioxidant 1010 and antioxidant 168, and the mass ratio of the two is 1: 1.
4. The polypropylene resin composition for medical syringes according to claim 1, wherein the acid scavenger is a stearate.
5. The polypropylene resin composition for medical syringes according to claim 1, wherein the lubricant is one of glyceryl monostearate, fatty acid metal salt, fatty amide or wax.
6. The polypropylene resin composition for medical syringes according to claim 1, wherein the nucleating agent is a phosphate-based nucleating agent or a sorbitol-based nucleating agent.
7. A preparation method of the polypropylene resin composition for medical syringes as claimed in any one of claims 1 to 6, characterized in that the polypropylene resin composition is obtained by weighing raw materials, stirring and mixing, extruding and granulating by a double screw.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610489861.XA CN107540953B (en) | 2016-06-28 | 2016-06-28 | Polypropylene resin composition for medical syringe and preparation method thereof |
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| CN201610489861.XA CN107540953B (en) | 2016-06-28 | 2016-06-28 | Polypropylene resin composition for medical syringe and preparation method thereof |
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| CN107540953A CN107540953A (en) | 2018-01-05 |
| CN107540953B true CN107540953B (en) | 2020-04-14 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109486031A (en) * | 2018-10-09 | 2019-03-19 | 中国石油化工股份有限公司 | A kind of rigidity-toughness balanced high-transparency polypropylene composition |
| CN109486006A (en) * | 2018-11-07 | 2019-03-19 | 宿迁市春明医疗器材有限公司 | A kind of injector for medical purpose PP material |
| CN112409681B (en) * | 2019-08-23 | 2022-08-12 | 中国石油化工股份有限公司 | Polypropylene composition and preparation method thereof |
| CN112812426A (en) * | 2020-12-30 | 2021-05-18 | 河南驼人医疗器械研究院有限公司 | Radiation-resistant polypropylene composition and preparation method and application thereof |
| CN113462075A (en) * | 2021-06-02 | 2021-10-01 | 高邮市汉升高分子材料有限公司 | Preparation method of polypropylene material for medical injector |
| CN114163720A (en) * | 2021-11-05 | 2022-03-11 | 北方华锦化学工业股份有限公司 | Special polypropylene material for two-piece type injector piston assembly and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1676545A (en) * | 2004-04-02 | 2005-10-05 | 中国石化上海石油化工股份有限公司 | Polypropylene resin for manufacturing medical syringe |
| CN101338056A (en) * | 2007-07-03 | 2009-01-07 | 中国石化上海石油化工股份有限公司 | Acrylic resin for manufacturing syringes for medical use |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1676545A (en) * | 2004-04-02 | 2005-10-05 | 中国石化上海石油化工股份有限公司 | Polypropylene resin for manufacturing medical syringe |
| CN101338056A (en) * | 2007-07-03 | 2009-01-07 | 中国石化上海石油化工股份有限公司 | Acrylic resin for manufacturing syringes for medical use |
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