CN107536035A - A kind of functional food containing ketone and application thereof - Google Patents
A kind of functional food containing ketone and application thereof Download PDFInfo
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- CN107536035A CN107536035A CN201710692620.XA CN201710692620A CN107536035A CN 107536035 A CN107536035 A CN 107536035A CN 201710692620 A CN201710692620 A CN 201710692620A CN 107536035 A CN107536035 A CN 107536035A
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- China
- Prior art keywords
- functional food
- containing ketone
- food containing
- gout
- hydroxybutyric acids
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Abstract
Contain β hydroxybutyric acids the present invention relates to a kind of functional food containing ketone, in the functional food and its content is in more than 50wt%, specifically comprise：The 75wt% of β hydroxybutyric acids 50, the 24wt% of smilax powder 6, the 15wt% of sodium citrate 5, the 10wt% of calcium carbonate 4, the 1.5wt% of sodium chloride 0.5, the 1.5wt% of STEVIA REBAUDIANA 0.2.The beneficial effects of the invention are as follows：The main effective ingredient of the functional food containing ketone is β hydroxybutyric acids, can be directly absorbed by the body after edible, can significantly alleviate urarthritis symptom of the gout patients in stage of attack, including arthralgia, redness and swelling of joints, joint heating etc.；After the rational proportion such as β hydroxybutyric acids and smilax powder, calcium carbonate, sodium citrate, the assimilation effect of β hydroxybutyric acids is more preferable；Functional food containing ketone provided by the invention it is direct-edible or as a kind of nourishing additive agent with prepare be applied to gout patient's stage of attack health food.
Description
Technical field
The invention belongs to functional food field, and in particular to a kind of functional food containing ketone and application thereof.
Background technology
Functional food is to improving physical condition or reducing a kind of appellation of ill food, also commonly referred to as protect
Health food.Functional food is eaten suitable for specific crowd, has regulation body function, not for the purpose for the treatment of disease, and it is right
Human body does not produce any acute, subacute or chronic hazard food.China popular at present is that have anti-oxidant, drop blood
Sugar, reducing blood lipid, relax bowel, alleviate physical fatigue, fat-reducing, the functional food for improving the effect such as immunity and functions of removing chloasma.But
There is no the edible guarantor's functional food of special suitable gout patients.
Gout is the disease of human body purine metabolism imbalance, shows as persistently increasing for blood uric acid.Blood uric acid, which increases, to be caused to urinate
Hydrochlorate crystal causes a series of clinical symptoms that gout breaks out in joint deposition, with living-pattern preservation in recent years, especially
It is the change of people's diet spectrum, the incidence of disease of hyperuricemia and gout continuously rises.At home, gout, which has become, is only second to
The second largest metabolic disease of diabetes.During the breaking-out of acute gouty arthritis, urate crystals are in joint, tendon and its outer
Organize the formation of crystallization week, cause gout to be broken out.Gout breaking-out is due to that gout crystallization induces local macrophage thin in molecule mechanism
The immune response of born of the same parents, it is by an inflammation complex being called containing NLRP3 (Inflammasome), this complex first
Activation caspase 1 enzymatic interleukin 1-beta (IL-1 β) precursor can be made to become interleukin-1 ' beta ', so as to lure
The inflammatory reaction for sending out cascade a series of.Newest research finds, gout crystallizes induced inflammatory body activation inflammatory process can be with
Blocked by a kind of material for being called beta-hydroxy-butanoic acid.
Beta-hydroxy-butanoic acid is a kind of ketoboidies, accounts for the 70% of ketoboidies total amount, is human body energy metabolic intermediate, is being continued
Important energy source material under motion and fasting starvation, under starvation, Hepatic contrast fatty acid metabolism, beta-hydroxy fourth in blood
Acid is increased to 1-2mM, long-time fasting, is increased to more than 6-8mM.Although it can be carried by continuous service and fasting to starvation
The content of high beta-hydroxy-butanoic acid in vivo, it is apparent that both modes are not easy to promote, the present invention provides a kind of functional food containing ketone,
It is intended to directly effectively improve the content of beta-hydroxy-butanoic acid in human body by eating the functional food, to alleviate urarthritis
Symptom.
The content of the invention
The present invention provides a kind of functional food containing ketone and application thereof, it is intended to makes up and lacks in the prior art effectively for pain
The deficiency of the functional food of wind patient.
The technical scheme that the present invention solves above-mentioned technical problem is as follows：A kind of functional food containing ketone, contain in the functional food
There is beta-hydroxy-butanoic acid and its content is in more than 50wt%.
On the basis of above-mentioned technical proposal, the present invention can also do preferred scheme further below.
Preferably, the functional food is made up of each raw material of following content：Beta-hydroxy-butanoic acid 50-75wt%, smilax powder
6-24wt%, sodium citrate 5-15wt%, calcium carbonate 4-10wt%, sodium chloride 0.5-1.5wt%, STEVIA REBAUDIANA 0.2-1.5wt%.
It should be noted that the chemical name of the sodium citrate in the constitutive material of the functional food be 2- hydroxy propanes-
1,2,3- sodium tricarboxylate's dihydrate, alias sodium citrate, it is colourless crystallization or white crystalline powder；It is odorless；In wet sky
It is micro- in gas to have hygroscopy, have in hot-air efflorescence properties, the compound preparation of readily soluble sodium citrate composition can alkalize urine in water
Liquid, for the improvement of gout and hyperuricemia aciduria, it can prevent, treat gout and can be combined with other medicines and controlled
Treat gout or hyperuricemia.
It should be noted that the smilax in the constitutive material of the functional food, specially liliaceous plant smilacis glabra
Dry rhizome, its be perennial evergreen climb shape shrub, be born in hillside or sylvan life more, be used as medicine part only select its dried
Rhizome, Chang Yuxia, the excavation of season in autumn two, removes fibrous root, dry after cleaning to be used as medicine；Or take advantage of and dry after fresh-cut flakiness, be used as medicine；Taste
It is sweet, light, it is mild-natured；Have removing toxic substances, dehumidify, it is easing joint movement the effect of, the limbs contraction that is mainly used in caused by syphilis and mercury poisoning, muscles and bones
Pain；Damp and hot stranguria with turbid discharge, with, carbuncle swells, scrofula, mange.
It should be noted that the main function of the calcium carbonate in the constitutive material of the functional food is to react to be formed with hydrochloric acid in gastric juice
The absorbent calcium of body, calcium carbonate are medically also acting as antacids, hydrochloric acid in gastric juice, protection ulcer surface can be neutralized, for hydrochloric acid in gastric juice mistake
The diseases such as more, gastric duodenal ulcer.
It should be noted that STEVIA REBAUDIANA, as pharmaceutical sweetener auxiliary material, the main component in its cured leaf is steviol glycoside,
Not only sugariness is high, heat is low, also has antihypertensive, blood glucose with certain pharmacological action, steviol glycoside analog derivative, resists swollen
Knurl, improve diarrhoea and improve the clinical efficacies such as body immunity.
In addition, present invention also offers the purposes of the above-mentioned functional food containing ketone, it adds middle dose as a kind of nutrition and is used for
Prepare with the health drink or food for alleviating urarthritis symptom.
Compared with prior art, the beneficial effects of the invention are as follows：The main effective ingredient of the functional food containing ketone is β-hydroxyl
Base butyric acid, it can be directly absorbed by the body after edible, can significantly alleviate urarthritis symptom of the gout patients in stage of attack, wrapped
Include arthralgia, redness and swelling of joints, joint heating etc.；The rational proportion such as beta-hydroxy-butanoic acid and smilax powder, calcium carbonate, sodium citrate
Afterwards, the assimilation effect of beta-hydroxy-butanoic acid is more preferable, more notable to the remission effect of urarthritis symptom；It is provided by the invention to contain
Ketone functional food is direct-edible or is eaten as a kind of nourishing additive agent with the health care prepared suitable for gout patient's stage of attack
Product.
Embodiment
Below in conjunction with specific embodiment, the present invention is described in further detail, and example is served only for explaining this hair
It is bright, it is not intended to limit the scope of the present invention.
Each raw material used in following examples is then commercially available prod unless otherwise noted.
Embodiment 1
A kind of functional food containing ketone, it is prepared by fully mixing by each raw material of following quality：Beta-hydroxy-butanoic acid 12g, native Fu
Siberian cocklebur powder 1.4g, sodium citrate 1.5g, calcium carbonate 1.25g, sodium chloride 0.5g, STEVIA REBAUDIANA 0.1g.
Directly taken with above-mentioned functional food containing ketone to 100 volunteers of gout stage of attack and (take 1 time daily, every time
10g), and record takes the change (using digit score method NRS evaluations pain intensity) of front and rear pain scoring, 100 volunteers
Pain is relieved after middle about 85% people takes 24h, it is common that is down to painless or mild pain by the 5-8 of moderate and severe pain
2-4, with wherein 5 for representative, shown in table specific as follows：
| Volunteer | Age | Sex | Stage of attack pain scores | Pain scores after taking 24 hours |
| 1 | 49 | Man | 6 | 3 |
| 2 | 51 | Man | 6 | 4 |
| 3 | 52 | Man | 5 | 2 |
| 4 | 40 | Man | 4 | 3 |
| 5 | 38 | Man | 7 | 3 |
Embodiment 2
A kind of functional food containing ketone, it is prepared by fully mixing by each raw material of following quality：Beta-hydroxy-butanoic acid 8g, smilax
Powder 2.7g, sodium citrate 2.2g, calcium carbonate 1.65g, sodium chloride 0.6g, STEVIA REBAUDIANA 0.3g.
Directly taken with above-mentioned functional food containing ketone to 100 volunteers of gout stage of attack and (take 1 time daily, every time
15g), and the change (evaluating pain intensity using digit score method NRS) for taking the scoring of front and rear pain is recorded, in 50 volunteers
Pain is relieved after about 90% people takes 24h, it is common that is down to by the 5-8 of moderate and severe pain painless or mild pain
2-3, with wherein 5 for representative, shown in table specific as follows：
| Volunteer | Age | Sex | Stage of attack pain scores | Pain scores after taking 24 hours |
| 1 | 29 | Man | 6 | 3 |
| 2 | 44 | Man | 7 | 4 |
| 3 | 55 | Man | 6 | 3 |
| 4 | 52 | Man | 8 | 4 |
| 5 | 47 | Man | 5 | 3 |
Comparative example 1
A kind of functional food containing ketone, identical with the component of functional food containing ketone of embodiment 1, difference is only not contain native Fu
Siberian cocklebur powder.
Directly taken with above-mentioned functional food containing ketone to 100 volunteers of gout stage of attack and (take 1 time daily, every time
10g), and record takes the change (using digit score method NRS evaluations pain intensity) of front and rear pain scoring, 100 volunteers
Pain is relieved after middle about 70% people takes 24h, that is, after lacking smilax powder, this contains ketone functional food and gout is broken out
Alleviation effect of phase patient decreases.Same have also been attempted default sodium citrate component, then be found through examining, default Chinese holly
The functional food also has reduction for the respective action of gout patients after rafter acid sodium.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent substitution and improvements made etc., it should be included in the scope of the protection.
Claims (3)
1. a kind of functional food containing ketone, it is characterised in that contain beta-hydroxy-butanoic acid in the functional food and its content is in 50wt%
More than.
2. one kind functional food containing ketone according to claim 1, it is characterised in that be made up of each raw material of following content：
Beta-hydroxy-butanoic acid 50-75wt%, smilax powder 6-24wt%, sodium citrate 5-15wt%, calcium carbonate 4-10wt%, sodium chloride
0.5-1.5wt%, STEVIA REBAUDIANA 0.2-1.5wt%.
3. the purposes of a kind of functional food containing ketone as described in any one of claim 1 to 2, it is characterised in that sought as one kind
Support add middle dose be used for prepare with alleviation urarthritis symptom health drink or food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710692620.XA CN107536035A (en) | 2017-08-14 | 2017-08-14 | A kind of functional food containing ketone and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710692620.XA CN107536035A (en) | 2017-08-14 | 2017-08-14 | A kind of functional food containing ketone and application thereof |
Publications (1)
| Publication Number | Publication Date |
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| CN107536035A true CN107536035A (en) | 2018-01-05 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210244694A1 (en) * | 2019-03-14 | 2021-08-12 | The Regents Of The University Of California | BHB-Citrate Combination Products for Renal Health and Treating Disease |
| WO2022173813A1 (en) * | 2021-02-09 | 2022-08-18 | The Regents Of The University Of California | Improved bhb-citrate formulations for promoting health |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101484152A (en) * | 2006-06-08 | 2009-07-15 | 舒沃茨药物股份公司 | Therapeutic combination for painful medical conditions |
| CN101678043A (en) * | 2007-03-30 | 2010-03-24 | 有限会社爱泽世 | Composition for promoting ketone compound formation |
-
2017
- 2017-08-14 CN CN201710692620.XA patent/CN107536035A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101484152A (en) * | 2006-06-08 | 2009-07-15 | 舒沃茨药物股份公司 | Therapeutic combination for painful medical conditions |
| CN101678043A (en) * | 2007-03-30 | 2010-03-24 | 有限会社爱泽世 | Composition for promoting ketone compound formation |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210244694A1 (en) * | 2019-03-14 | 2021-08-12 | The Regents Of The University Of California | BHB-Citrate Combination Products for Renal Health and Treating Disease |
| WO2022173813A1 (en) * | 2021-02-09 | 2022-08-18 | The Regents Of The University Of California | Improved bhb-citrate formulations for promoting health |
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Application publication date: 20180105 |