CN107530039A - Die body and method for the quality assurance of particle therapy devices - Google Patents
Die body and method for the quality assurance of particle therapy devices Download PDFInfo
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- CN107530039A CN107530039A CN201680022629.3A CN201680022629A CN107530039A CN 107530039 A CN107530039 A CN 107530039A CN 201680022629 A CN201680022629 A CN 201680022629A CN 107530039 A CN107530039 A CN 107530039A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/58—Testing, adjusting or calibrating apparatus or devices for radiation diagnosis
- A61B6/582—Calibration
- A61B6/583—Calibration using calibration phantoms
- A61B6/584—Calibration using calibration phantoms determining position of components of the apparatus or device using images of the phantom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/12—Devices for detecting or locating foreign bodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/40—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for generating radiation specially adapted for radiation diagnosis
- A61B6/4007—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for generating radiation specially adapted for radiation diagnosis characterised by using a plurality of source units
- A61B6/4014—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for generating radiation specially adapted for radiation diagnosis characterised by using a plurality of source units arranged in multiple source-detector units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
- A61N5/1043—Scanning the radiation beam, e.g. spot scanning or raster scanning
- A61N5/1044—Scanning the radiation beam, e.g. spot scanning or raster scanning with multiple repetitions of the scanning pattern
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1071—Monitoring, verifying, controlling systems and methods for verifying the dose delivered by the treatment plan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1075—Monitoring, verifying, controlling systems and methods for testing, calibrating, or quality assurance of the radiation treatment apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
- A61N2005/105—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using a laser alignment system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
- A61N2005/1061—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using an x-ray imaging system having a separate imaging source
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1075—Monitoring, verifying, controlling systems and methods for testing, calibrating, or quality assurance of the radiation treatment apparatus
- A61N2005/1076—Monitoring, verifying, controlling systems and methods for testing, calibrating, or quality assurance of the radiation treatment apparatus using a dummy object placed in the radiation field, e.g. phantom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/1087—Ions; Protons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
- A61N5/1043—Scanning the radiation beam, e.g. spot scanning or raster scanning
Abstract
The invention provides the die body and method of the quality assurance of the particle therapy devices for being used in strong particle therapy pattern is adjusted.The die body includes：Frame structure；One or more voussoirs；First material block and the second material block, first material block and second material block each have first piece of face and the second piece face parallel with first piece of face；The absolute dosages meter being arranged at first piece of face；Multiple high density material pearls in described piece；And 2D detectors.These parts are arranged in known fixed position relative to the frame structure.Center bead is maintained in known central fixed position relative to the frame structure.These parts are arranged in the frame structure so that beam will cross die body through center bead, without through any material in addition to the center bead.
Description
Technical field
The present invention relates to the field of particle therapy.More particularly, the present invention relate to adjust strong particle therapy (IMPT) mould
The die body and method of the quality assurance of the particle therapy devices of formula (also referred to as pencilbeam scanning technique).
Background technology
In current proton beamlets facility, pencilbeam scanning technique (PBS), which is related to, shines the point separated in target
Penetrate, each point has predetermined position and depth, and provides predetermined dosage for each point.In each therapeutic room of facility,
The different qualities of beam through delivering are subjected to daily check routine.These characteristics are：
Bragg peak of-the beam area-in targeting (being typically Water ball or multilayer ionisation chamber) under given beam energy
Position,
- by the point position and point size, the detector of suitable 2D detectors measures it is, for example, ionisation chamber array or equipped with CCD
The scintillator screen of camera,
- the deposit dose measured by absolute ionisation chamber, for checking the output factor of irradiation installation.
Each in these characteristics is generally measured by single measurement apparatus in multiple different beam energies levels.Completely
Inspection be related to many manually operated, including enter therapeutic room to be adapted to die body or measurement apparatus.Therefore, check routine institute is completed
The time needed is the magnitude of 30 minutes to 60 minutes.In terms of the treatment number of times that can be performed daily, the Check-Out Time of this length
Reduce the efficiency for the treatment of facility.
File EP 2422847 is related to a kind of dosimetry device, and the dosimetry device is used in standard and conformal radiation
Especially examine in (that is, high-energy X-rays rather than particle) treatment and in IMRT (IMRT) beam of radiation.Should
Device includes active region and accumulation plate, and the active region includes the line of radiation detector, and the accumulation plate is equipped with different-thickness
Degradator.This device is designed to have the work(for being intended to examine the multi-diaphragm collimator generally used in radiotherapy equipment
The specific purposes of energy, but it is not used in the global inspection for performing particle therapy devices.This device is not suitable for measuring beam of particles
Beam area because the thickness of accumulation plate does not adapt to the position of the bragg peak as caused by the hadron beam of predetermined power.
File WO 2013160379 discloses the apparatus and method examined for hadron beam, and it allows to examine by particle
The characteristic (including scope, point size and point position) of the beam of therapeutic equipment transmitting.However, this apparatus and method are not set
Count for carrying out global inspection to the particle therapy devices including parts such as patient positioning system, RX radiation imaging systems.
Not providing allows to determine beam of particles and one or more x-ray sources or the device being correctly aligned of patient positioning system.
The content of the invention
It is an object of the invention to provide the particle therapy devices for being used in strong particle therapy (IMPT) pattern is adjusted
The die body and method of quality assurance, it allows to carry out particle therapy devices fast and reliable inspection.More precisely, it is necessary to one
Kind allow to by the beam of particles that particle therapy devices are launched relative to each self-contained x-ray source and 2D X-ray detectors two
The die body that individual or more x-ray system is aligned.
The present invention is defined by the independent claims.Dependent claims limit advantageous embodiment.
According to the first aspect of the invention, there is provided one kind can be used for the particle therapy for adjusting strong particle therapy (IMPT) pattern
The die body of the quality assurance of equipment, the die body include：(a) frame structure, the frame structure has to be made up of RX transmissive materials
Multiple edges, there is the first face and the second face parallel to first face；(b) one or more voussoirs, this or more
Individual voussoir each have towards first face orientation and the first wedge surface in parallel and with first face opposite orientation
And relative to inclined second wedge surface in first face；(c) the first material block, first material block have towards first face
Orient and in parallel first piece of face and towards second face orientation and in parallel second piece of face, absolute dosages
Meter is arranged at first piece of face；(d) the second material block, second material block have towards first face orient and with
Its first piece of parallel face and towards second face orientation and in parallel second piece of face；(e) multiple high density materials
Pearl, the plurality of high density material pearl positioned at described first piece and/or it is described second piece in；(f) it is arranged at second face
2D detectors.According to the present invention, one or more of voussoirs, first material block, the absolute dosages meter, described
Two material blocks, the multiple high density material pearl and the 2D detectors are in known fixed relative to the frame structure
Position.The die body of the present invention can include the high density material being maintained at relative to the frame structure in known central fixed position
Expect center bead, one or more of voussoirs, first material block and second material block are arranged at the framework knot
In structure so that the beam that the die body is crossed from first face and perpendicular to it through the center bead is up to described second
Face is without crossing any material in addition to the center bead.
Preferably, the frame structure is in polyhedral shape, more preferably rectangular cubic.
Multiple visual indicias can be arranged on the known position at one or more of edge edge.
Preferably, one or more voussoirs are included between first wedge surface and second wedge surface distance in 20mm
To the part between 315mm and made of the material with water equivalent radiated power absorption characteristic.By distance as selection, by
The particle therapy devices are launched and penetrate the bragg peak of the beam of particles in the first voussoir face will be in second wedge surface
Place occurs, in the beam energy being generally used in the energy range of particle therapy.
Preferably, these voussoirs and/or this first piece and/or this second piece are by the material with water equivalent radiated power absorption characteristic
Material is made.Material with water equivalent radiated power absorption characteristic is that wherein beam of particles is lost during it advances through material
As it in water at identical penetration range by the material of the same amount of energy of loss.
Preferably, the 2D detectors are maintained at by means of multiple clips on the edge in second face.
Preferably, the plurality of high density material pearl is diameter in 1mm to the metal ball body between 3mm.
According to the second aspect of the invention, there is provided one kind can be used for the particle therapy for adjusting strong particle therapy (IMPT) pattern
The method of the quality assurance of equipment, the equipment include that there are the patient positioner of reference position and two or more X to penetrate
Linear system is united, and described two or more x-ray systems each include x-ray source and 2D X-ray detectors, this method including with
Lower step：
A) die body according to the present invention is provided；
B) die body is positioned on the patient positioner；
C) patient positioner is positioned at the reference position；
D) die body is irradiated and described with the pencilbeam for the known central fixed position for pointing to the die body
The image of the pencilbeam is obtained on 2D detectors；
E) distance between the center bead and the pencilbeam is calculated from described image.
Preferably, this method is additionally may included in the following steps between step b) and step c)
F) patient positioner is positioned at the known offset vector away from the reference position；
G) one or more radioscopic images of the die body are obtained on the 2D X-ray detectors；
H) calculate and be used for the patient positioner from the image of the high density material pearl on the 2D X-ray detectors
It is moved to the updating vector of the reference position；
I) the described of the offset vector and the updating vector is examined and less than threshold value；
It is highly preferred that this method is additionally may included in the following steps after step c)
J) die body (10) is irradiated to each multiple pencilbeams with identical energy and obtained in the 2D detectors
(180) image of the pencilbeam on；
K) beam area, point size, point position are calculated from described image；
L) dose of radiation is obtained from the absolute radiation detector (130)；
M) examine beam area, described size, described position and the dose of radiation expected beam area,
In the range of point size, point position and dose of radiation.
Alternatively, there is provided one kind is used for the quality assurance for adjusting the particle therapy devices of strong particle therapy (IMPT) pattern
Method, the equipment include with reference position patient positioner and two or more x-ray systems, this two or
More x-ray systems each include x-ray source and 2D X-ray detectors, this method comprise the following steps：
N) die body according to the present invention is provided；
O) die body is positioned on the patient positioner；
P) patient positioner is positioned at the known offset vector away from the reference position；
Q) one or more radioscopic images of the die body are obtained on the 2D X-ray detectors；
R) calculated from the image of the benchmark on the 2D X-ray detectors for the patient positioner to be moved into institute
State the updating vector of reference position；
S) the described of the offset vector and the updating vector is examined and less than threshold value；
T) patient positioner is positioned at the reference position；
U) die body is irradiated to each multiple pencilbeams with identical energy and obtained on the 2D detectors
The image of the pencilbeam；
V) beam area, point size, point position are calculated from described image；
W) from the absolute radiation detector acquisition dose of radiation；
X) examine beam area, described size, described position and the dose of radiation expected beam area,
In the range of point size, point position and dose of radiation.
According to preferable method, when the die body has been included in one or more of these frame edges frame edge
When knowing multiple visual indicias of opening position, this method may comprise steps of
A) one or more light or the sector directed of laser are arrived into the visual indicia；
B) sector of light or laser and the uniformity of the visual indicia are examined.
, can be with repeat step j) to m) for different beam energies.
Advantageously, step c) performs at least one step in m) automatically under program control.
According to the third aspect of the invention we, there is provided a kind of computer program, the computer program include being used to perform sheet
The step c) of the method for invention at least some steps in m) code.
According to the fourth aspect of the invention, there is provided a kind of system, the system include the die body and control according to the present invention
Device processed, the controller include the computer program according to the present invention, and the system is used for the quality assurance of particle therapy devices.
According to the 5th and the last aspect of the present invention, there is provided a kind of mould of quality assurance for particle therapy devices
Body, the die body include
A) it is used for the 2D detectors for detecting particle, the 2D detectors have xy detector planes；
B) wedge, the wedge have the surface parallel with the xy detector planes and put down relative to the xy detectors
The inclined surface in face；
C) 2 or more in the first support block imaging mark
D) it is configured for supporting second piece of dosimeter detector
Wherein the die body also includes the reference marker along the line positioning substantially perpendicular to the xy detector planes, and its
In the wedge, this first piece and this second piece be positioned and configured to not intercept the line.
Brief description of the drawings
These of the present invention will be explained in more detail with further aspect by way of example and refer to the attached drawing, attached
In figure：
Fig. 1 is the perspective view of die body according to an embodiment of the invention；
Fig. 2 is the perspective view for the identical die body seen from opposite side；
Fig. 3 is the perspective view of the voussoir of the die body；
Fig. 4 is the schematic diagram of the beam and respective image that cross voussoir；
Fig. 5 is the center bead of identical die body and the schematic diagram of respective image；
Fig. 6 a and Fig. 6 b are the schematic diagram of the die body in known offset opening position and in reference position respectively；B points of Fig. 7 a and Fig. 7
It is not the schematic diagram of the multiple pencilbeams and respective image of irradiation；
Fig. 8 is the detailed view for the device that film is fastened to frame structure.
Description in accompanying drawing had both been not drawn on scale or disproportionate.Generally, in the accompanying drawings, identical part is by identical
Reference number indicates.
Embodiment
Fig. 1 is the perspective view of die body 10 according to an embodiment of the invention.Frame structure 30 includes one group of edge 40 and shape
Into polyhedron, in shown example, the polyhedron is rectangle cuboid.First face of the cuboid may be used as beam and enter
Penetrate face, i.e., should be facing to beam source orientation when using die body.These edges are by X ray transmissive material (for example, carbon is fine
Dimension) it is made and is for example assembled in the case of without sheet metal by gluing.Die body 10 includes what be will be described later
A series of voussoirs 70.Die body includes the first material block 100, and first material block has the first face 110 and the second face 120, and this
The first face 50 and the second face 60 of frame structure 30 are simultaneously respectively parallel to second face.Absolute dosages meter 130 be located at this
One piece of the first face 110 and the dosage launched available for measurement by beam source.Ionisation chamber may be used as absolute dosages meter.
Open channel is provided between first material block 110 and the second material block 140, its allow beam through the first face 50 and perpendicular to
First face enters die body 10, so as to pass through frame structure without crossing except the high density of the center line positioning along the passage
Any material outside material center pearl, the high density material center bead are conveniently located at the first face 50 through frame structure 30
On the line at the center in the second face 60.The center bead 175 can conveniently by be attached to die body 10 a part (for example,
Be attached to as illustrated in fig. 1 second piece 140) on the bar that comes of X ray transmissive material be maintained at the position.Except center bead
Outside 175, one group of additional pearl 170 is located at the known position in die body.In shown example, two pearls 170 are positioned at the
On two piece 140 of the first face 150, and two pearls 170 are in first piece 100 of upper side.By the method according to the invention
To explain the function of these pearls 170,175 and effect." high density material " refers to density higher than 1 to cause pearl in x-ray imaging
Under be visible and be visible material on 2D detectors when under beam of particles.The pearl made of metal (for example, steel)
It is convenient for this purpose.Use range is found convenient for 1mm to 3mm spheroid (for example, 2mm spheroid) and provides foot
Enough image visibilities and good positioning precision.Pearl can be fixed in the hole drilled out in material block.Multiple visual indicias 200
The known position that can be arranged on the edge 40 of frame structure 30.The function of these visual indicias 200 is discussed below
And purposes.
Fig. 2 is the perspective view for the identical die body seen from opposite side, shows same parts.In shown example, carry
Supplied four voussoirs, and the second wedge surface 90 relative to the second face 60 of frame structure 30 with 24 ° of angle tilt.Show
One piece 100 of the second face 120 and second piece of the second face 160.
Fig. 3 is the perspective view of the voussoir of Fig. 2 die body.Two top voussoirs have 65mm beam road at upper part
Electrical path length, in beam path length of the base portion office with 20mm and the path length with 42.5mm at intermediate altitude
Degree.When voussoir is made up of water equivalent material, this corresponds to the bragg peak of the proton beamlets of the energy with 73.37MeV
Depth.Similarly, bottom, right voussoir is dimensioned to have corresponding to 106.4MeV energy at intermediate altitude
82.5mm path length, and the left voussoir in bottom be dimensioned at intermediate altitude have correspond to 172.53MeV
Energy bragg peak 192.5mm path length.Length with such as 70mm, 100mm, 200mm and 250mm is added
Block can be attached to top voussoir (by shown dovetail component), be corresponded to reaching respectively at intermediate altitude
142.25mm, 242.50mm and 292.50mm of 145.13MeV, 197.22MeV, 220.9MeV bragg peak depth path
Length.As known in the art, a kind of particle therapy devices are devised and are located at patient's body certain limit depth for treatment
The tumour at place.Therefore, the equipment is designed to produce the bragg peak depth with producing corresponding to the depth bounds
Energy range beam of particles.
It is used to measure the beam needed for particle therapy devices to be tested in scope skilled artisan would know how selection
The size of one or more voussoirs of energy.
Fig. 4 illustrates how to determine beam energy using the die body and method of the present invention.Beam (or one group of single pen
Shape beam) point to the first face 80 of one or more voussoirs.Measurement beam passes through the dosage that is deposited on after voussoir in 2D detectors.
Correspond to bragg peak at the height of the dosage maximum wherein detected, and corresponding path length 210 gives cloth outputting in voussoir
Glug peak depth, bragg peak depth correspond to beam energy in known manner.
Using the die body of the present invention, the function of the part of radiotherapy equipment, including X can be efficiently and quickly examined to penetrate
Line imaging source and detector, the alignment system and control system for managing these parts.The die body is located at patient positioner
At calibration position on (patient table).The patient positioner is positioned at the known offset opening position away from reference position.The bits of offset
Spatial translation (x, y, z) and angle direction and orientation can be included by putting.Then using x-ray imaging system shooting die body, and
And can from the pearl 170 on X-ray detector and the image of pearl 175 correction vector by known methods.Skew and
The increase of correction (translation and rotation) should be zero, and any deviation from zero should be considered as the potential default value in system.
All these steps can be performed advantageously under program.Acquired radioscopic image can be handled by program, to count
Calculate updating vector.Then, patient positioner is moved to reference position.The reference position may be such that 2D detectors are located at grain
Position at the isocenter point of sub- therapeutic equipment.In this stage, additional inspection can also be carried out to examine die body to be in just
True position：One group of (laser) light source is arranged on fixation and known position and the fan for guiding (laser) light around reference position
Shape beam.Source is installed and guided, to reach the visual indicia 200 on the edge of frame structure 30.Observation is at these
The image of these fan beams on mark 200, to determine that die body is in correct position.Again, these steps (including figure
The acquisition and processing of picture) advantageously automatic under program it can perform.Fig. 6 a and Fig. 6 b are in known offset position respectively
Place and the schematic diagram of die body in reference position.
The function of center bead 175 will be discussed now.When die body has been located at reference position, beam of particles is in
Heart line points to die body.The respective image from 2D detector acquisitions is shown in Fig. 5 centre, and is shown in Fig. 5 right part
Corresponding curve map is gone out.Peak corresponds to beam, and the centre of form at the peak can be for example by the way that the midpoint between 2 points be located at
Determined at the intermediate altitude at peak.Valley at the top at peak is caused by being absorbed caused by pearl 175.In this valley
The heart corresponds to the position of pearl.The curve map allows the alignment for examining beam relative to the geometric alignment performed with x-ray system.Penetrate
The centre of form at the peak of beam should be with the center superposition of the valley of jag part caused by center bead 175.The side of control centre's beam
To, collection 2D detectors and processing image with provide examine signal the step of can perform automatically under program.
Fig. 7 a represent to produce and point to the beam of the die body in reference position by radiotherapy equipment under program
Sequence.Fig. 7 b represent the respective image from the collection of 2D detectors.Different parameters, such as beam can be obtained from these images
Energy and alignment, as described above.Spot size can also be examined in known manner and puts position.
Frame structure 30 be present in the die body 10 of the present invention to have many advantages：Die body, framework can be easily manipulated
It is the reliable and accurate reference for the position of all parts of die body, mark 200 allows to utilize laser inspection exact position.
In addition, edge 40 can be used for attaching the part on framework：2D detectors can be kept by multiple plastic grips 220
Film detector on framework, as shown in Figure 8.2D detectors can also be the detector based on scintillator for having camera, and
Framework is attached to by multiple clips 220.
By using the die body and method of the present invention, in a reliable fashion can be carried out to the function of particle therapy devices day
Often examine, include the part of the equipment, such as alignment system, x-ray imaging system, beam guiding system and dosage.When
When being performed under programme-control, especially efficiently and quickly, its permission performs complete quality assurance to this method in less than 10 minutes.
Using the method for the present invention, therapist saves many time-consuming operations, such as into therapeutic room to carry out die body change, and
Therapeutic room is left to measure.
With regard to specific embodiment, invention has been described, these specific embodiments be the description of the invention without
It should be construed as limitation.More generally, it will be appreciated by those skilled in the art that the present invention is not limited to above
Content through specifically illustrating and/or describing.
Reference number in claims is not intended to limit its protection domain.Verb " comprising ", "comprising", " by ... formed "
Or any other variant and the paradigmatic element using outside those for being not precluded from being stated of their correspondence are deposited
.Before element using article "one", " one kind " or " described " be not precluded from this multiple dvielement being present.
Claims (17)
1. one kind can be used for the die body (10) for adjusting the quality assurance of the particle therapy devices of strong particle therapy (IMPT) pattern, the mould
Body includes：
A) frame structure (30), the frame structure with made of RX transmissive materials multiple edges (40), with the first face
And the second face (60) parallel to first face (50)；
B) one or more voussoirs (70), one or more voussoirs each have towards first face orientation and it is in parallel
The first wedge surface (80) and with first face opposite orientation and relative to inclined second wedge surface of the first face (50)
(90)；
C) the first material block (100), first material block have towards first face orientation and in parallel first piece of face
(110) and towards second face (60) orientation and in parallel second piece of face (120), absolute dosages meter (130) pacified
Come first piece of face (110) place；
D) the second material block (140), second material block have towards first face orientation and in parallel first piece of face
(150) and towards second face (60) orientation and in parallel second piece of face (160)；
E) multiple high density material pearls (170), the plurality of high density material pearl are located at first piece (110) and/or described
In two pieces (140)；
F) the 2D detectors (180) being arranged at second face；
It is one or more of voussoirs (70), first material block, the absolute dosages meter, second material block, described
Multiple high density material pearls (170) and the 2D detectors (180) are in known fixed relative to the frame structure (30)
Position,
It is characterized in that
High density material center bead (175) is maintained at the known secured centered position relative to the frame structure (30)
In, one or more of voussoirs (70), first material block (100) and second material block (140) are arranged at institute
State in frame structure (30) so that cross the mould from first face (50) and perpendicular to it through the center bead (175)
The beam of body (10) is up to second face (60) without crossing any material in addition to the center bead (175).
2. die body (10) according to claim 1, it is characterised in that the frame structure (30) is in polyhedral shape.
3. die body (10) according to claim 2, it is characterised in that the polyhedron is rectangle cuboid.
4. die body (10) according to any one of claim 1 to 3, it is characterised in that multiple visual indicias (200) are set
Put the known position at one or more of the edge (40) edge.
5. die body (10) according to any one of claim 1 to 4, it is characterised in that one or more of voussoirs
(70) it is included between first wedge surface (80) and second wedge surface (90) distance in 20mm between 315mm and by having
There is part (210) made of the material of water equivalent radiated power absorption characteristic.
6. die body (10) according to any one of claim 1 to 5, it is characterised in that one or more of voussoirs
(70) and/or first piece (100) and/or second piece (140) are by the material system with water equivalent radiated power absorption characteristic
Into.
7. die body (10) according to any one of claim 1 to 6, it is characterised in that the 2D detectors (180) by
It is maintained in multiple clips (220) on the edge (40) of second face (60).
8. die body (10) according to any one of claim 1 to 7, it is characterised in that the multiple high density material pearl
(170,175) are diameters in 1mm to the metal ball body between 3mm.
9. one kind can be used for the method for adjusting the quality assurance of the particle therapy devices of strong particle therapy (IMPT) pattern, the equipment
Including with the patient positioner of reference position and two or more x-ray systems, two or more x-ray systems
Each include x-ray source and 2D X-ray detectors, this method comprise the following steps：
A) die body (10) according to any one of claim 1 to 8 is provided；
B) die body (10) is positioned on the patient positioner；
C) patient positioner is positioned at the reference position；
D) with the pencilbeam for the known central fixed position for pointing to the die body irradiate the die body (10) and
The image of the pencilbeam is obtained on the 2D detectors (180)；
E) calculated from described image in the distance between the center bead (175) and the pencilbeam.
10. according to the method for claim 9, be additionally included in step b) and c) between following steps
F) patient positioner is positioned at the known offset vector away from the reference position；
G) one or more radioscopic images of the die body (10) are obtained on the 2D X-ray detectors；
H) calculate and be used for the trouble from the image of the high density material pearl (170,175) on the 2D X-ray detectors
Person's locator is moved to the updating vector of the reference position；
I) the described of the offset vector and the updating vector is examined and less than threshold value；
11. the method according to claim 9 or 10, the following steps being additionally included in after step c)
J) die body (10) is irradiated to each multiple pencilbeams with identical energy and obtained in the 2D detectors
(180) image of the pencilbeam on；
K) beam area, point size, point position are calculated from described image；
L) dose of radiation is obtained from the absolute radiation detector (130)；
M) examine beam area, described size, described position and the dose of radiation expected beam area,
In the range of point size, point position and dose of radiation.
12. the method according to any one of claim 9 to 11, wherein the die body (10) is included in the edge (40)
One or more of the known position at edge multiple visual indicias (200), this method is further comprising the steps of
N) one or more light or the sector directed of laser are arrived into the visual indicia (200)；
O) sector of light or laser and the uniformity of the visual indicia (200) are examined.
13. the method according to claim 9 or 12, in addition to for different beam energy repeat step j) to step m)
Suddenly.
14. the method according to any one of claim 9 to 13, wherein performing step c) extremely automatically under program control
M) at least one step in.
15. a kind of computer program, including for performing step c) according to claim 9 to e), and/or according to right
It is required that step f) described in 10 is to i), and/or step j) according to claim 11 is to m), and/or according to claim
Step n) described in 12 is to code o).
16. a kind of system, the system includes die body according to any one of claim 1 to 9 (10) and controller, should
Controller includes computer program according to claim 15, and the system is used for the quality assurance of particle therapy devices.
17. a kind of die body (10) of quality assurance for particle therapy devices, the die body include
A) it is used for the 2D detectors (180) for detecting particle, the 2D detectors have xy detector planes (60)；
B) wedge (70), the wedge have the surface (80) parallel with the xy detector planes (60) and relative to institutes
State the inclined surface of xy detector planes (60)；
C) 2 or more in the first support block (140) imaging mark (170)；
D) second piece (100), this second piece is configured for supporting dosimeter detector (130)
Characterized in that, the die body (10) also includes the ginseng along the line positioning substantially perpendicular to the xy detector planes
Mark (175) is examined, and wherein the wedge (70), first piece (140) and second piece (100) are positioned and configured to
The line is not intercepted.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15165139 | 2015-04-24 | ||
| EP15165139.5 | 2015-04-24 | ||
| PCT/EP2016/059009 WO2016170115A1 (en) | 2015-04-24 | 2016-04-22 | Phantom and method for quality assurance of a particle therapy apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107530039A true CN107530039A (en) | 2018-01-02 |
| CN107530039B CN107530039B (en) | 2020-05-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680022629.3A Active CN107530039B (en) | 2015-04-24 | 2016-04-22 | Phantom and method for quality assurance of particle therapy devices |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10105119B2 (en) |
| EP (1) | EP3285869B1 (en) |
| JP (1) | JP6625662B2 (en) |
| CN (1) | CN107530039B (en) |
| WO (1) | WO2016170115A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109745634A (en) * | 2018-12-25 | 2019-05-14 | 江苏海明医疗器械有限公司 | A kind of medical accelerator multi-diaphragm collimator test device |
| CN112076397A (en) * | 2019-06-13 | 2020-12-15 | 离子束应用股份有限公司 | Quality assurance mold and method for hadron therapy devices |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3421086B1 (en) * | 2017-06-28 | 2020-01-15 | OptiNav Sp. z o.o. | Determination of geometrical information about a medical treatment arrangement comprising a rotatable treatment radiation source unit |
| GB2603764B (en) * | 2021-02-10 | 2023-05-17 | Elekta ltd | Detection device for determining a position of a phantom |
| CN113031048B (en) * | 2021-03-05 | 2022-11-15 | 中国科学院近代物理研究所 | Device and method for fast quality control verification of ion beam range |
| KR102593247B1 (en) * | 2021-06-21 | 2023-10-24 | 주식회사 쓰리디산업영상 | Geometric calibration method and apparatus of computer tomography |
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| US7714309B2 (en) * | 2007-02-27 | 2010-05-11 | Wisconsin Alumni Research Foundation | Phantom for ion range detection |
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- 2016-04-22 JP JP2017555312A patent/JP6625662B2/en active Active
- 2016-04-22 CN CN201680022629.3A patent/CN107530039B/en active Active
- 2016-04-22 WO PCT/EP2016/059009 patent/WO2016170115A1/en active Application Filing
- 2016-04-22 US US15/567,879 patent/US10105119B2/en active Active
- 2016-04-22 EP EP16718336.7A patent/EP3285869B1/en active Active
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| EP0514971A1 (en) * | 1991-05-22 | 1992-11-25 | Philips Electronics Uk Limited | Apparatus and a method for verifying a target position |
| US20080219410A1 (en) * | 2007-03-07 | 2008-09-11 | Konstanze Gunzert-Marx | Phantom and method for quality monitoring of a medical system |
| DE202011104321U1 (en) * | 2011-08-12 | 2011-11-16 | Universitätsklinikum Frankfurt am Main | Measuring phantoms for checking the positioning accuracy of patient positioning devices in percutaneous radiotherapy on CTs, simulators and linear accelerators as well as the imaging properties of their imaging systems and the correct data transmission and data handling between the different systems (NK-100) |
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| CN109745634A (en) * | 2018-12-25 | 2019-05-14 | 江苏海明医疗器械有限公司 | A kind of medical accelerator multi-diaphragm collimator test device |
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| CN112076397A (en) * | 2019-06-13 | 2020-12-15 | 离子束应用股份有限公司 | Quality assurance mold and method for hadron therapy devices |
| CN112076397B (en) * | 2019-06-13 | 2022-08-09 | 离子束应用股份有限公司 | Quality assurance mold and method for hadron therapy devices |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107530039B (en) | 2020-05-05 |
| WO2016170115A1 (en) | 2016-10-27 |
| US20180098745A1 (en) | 2018-04-12 |
| US10105119B2 (en) | 2018-10-23 |
| EP3285869A1 (en) | 2018-02-28 |
| JP6625662B2 (en) | 2019-12-25 |
| JP2018513746A (en) | 2018-05-31 |
| EP3285869B1 (en) | 2019-06-12 |
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