CN107525744B - Magnetoelastic sensor for measuring blood viscoelasticity - Google Patents
Magnetoelastic sensor for measuring blood viscoelasticity Download PDFInfo
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- CN107525744B CN107525744B CN201710806699.4A CN201710806699A CN107525744B CN 107525744 B CN107525744 B CN 107525744B CN 201710806699 A CN201710806699 A CN 201710806699A CN 107525744 B CN107525744 B CN 107525744B
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- 239000008280 blood Substances 0.000 title claims abstract description 19
- 210000004369 blood Anatomy 0.000 title claims abstract description 19
- 239000000523 sample Substances 0.000 claims abstract description 66
- 239000000463 material Substances 0.000 claims abstract description 42
- 230000000737 periodic effect Effects 0.000 claims abstract description 5
- 230000000694 effects Effects 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 238000005259 measurement Methods 0.000 abstract description 10
- 230000035945 sensitivity Effects 0.000 abstract description 4
- 230000008859 change Effects 0.000 description 9
- 238000001514 detection method Methods 0.000 description 7
- 230000004044 response Effects 0.000 description 5
- 230000000670 limiting effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 206010011409 Cross infection Diseases 0.000 description 2
- 206010029803 Nosocomial infection Diseases 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
- G01N11/10—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material
- G01N11/16—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material by measuring damping effect upon oscillatory body
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- Physics & Mathematics (AREA)
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- Analytical Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Measuring Magnetic Variables (AREA)
Abstract
The present case discloses a magnetoelastic sensor for measuring blood viscoelasticity, including: a magnetic cup; the coil framework is coaxially arranged in the magnetic cup, a coil is wound on the outer surface of the coil framework, and a fixed bias magnetic field is arranged in the coil framework; an end cap for fixing the bobbin; a magnetostrictive material strip disposed in the bias magnetic field; one end of the probe adapter is fixedly connected with the magnetostrictive material strip, and the other end of the probe adapter is fixedly connected with a disposable probe so as to realize linkage of the three; when alternating current passes through the coil, an alternating magnetic field is generated inside the coil, and the magnetostrictive material strips generate periodic axial stretching vibration in the alternating magnetic field. The magneto-elastic sensor adopts magnetostrictive materials as sensitive elements, so the sensor has high sensitivity, can realize non-contact measurement and has low cost.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a magneto-elastic sensor for measuring blood viscoelasticity.
Background
The blood viscoelasticity test is of great significance as an important content of blood rheology, and can be used for diagnosing and monitoring diseases. For example, physiological conditions that lead to changes in plasma proteins (e.g., fibrin) can cause changes in ESR and plasma viscosity, and their correlation with haemorheology can be a good indicator of prognosis, diagnosis and monitoring of disease progression for diseases such as cancer, cardiovascular disease, and the like. At present, most of the sensors for detecting the viscoelastic force adopt a vibrating viscoelastic force sensor, the sensor generally uses a mechanical probe, the probe is driven by a circuit to generate periodic vibration, the vibrating probe is immersed into liquid or gel to be detected, the movement state of the probe is changed under the influence of the change of the viscoelastic force of an object to be detected, and the change of the movement state of the probe is detected by a proper method, so that the viscoelastic force of the object to be detected can be represented by the detected movement state of the probe. However, in the vibration sensor, the sensing element is a probe, the sensing element is directly contacted with an object to be detected, the vibration sensor is extremely easy to damage, the low-frequency response of the vibration sensor is poor, and the sensitivity is not high.
Disclosure of Invention
It is an object of the present invention to solve at least the above problems and to provide at least the advantages to be described later.
It is still another object of the present invention to provide a magnetoelastic sensor for measuring blood viscoelasticity, which uses magnetostrictive material as a sensing element, and the magnetostrictive material has short response time for producing magnetostrictive effect, so as to realize high-sensitivity and low-cost measurement of blood viscoelasticity.
To achieve these objects and other advantages and in accordance with the purpose of the invention, there is provided a magnetoelastic sensor for measuring a blood viscoelasticity, including:
a magnetic cup;
the coil framework is coaxially arranged in the magnetic cup, a coil is wound on the outer surface of the coil framework, and a fixed bias magnetic field is arranged in the coil framework;
an end cap for fixing the bobbin;
a magnetostrictive material strip disposed in the bias magnetic field;
one end of the probe adapter is fixedly connected with the magnetostrictive material strip, and the other end of the probe adapter is fixedly connected with a disposable probe so as to realize linkage of the three;
when alternating current passes through the coil, an alternating magnetic field is generated inside the coil, the magnetostrictive material strip generates periodic axial stretching vibration in the alternating magnetic field, the disposable probe is immersed into an object to be measured, and the viscous elastic force of the object to be measured changes the vibration state of the magnetostrictive material strip.
Preferably, the bias magnetic field is generated by a permanent magnet, and the permanent magnet is coaxially arranged at the outer side of the coil framework.
Preferably, the bias magnetic field is generated by superimposing a constant bias direct current on the alternating current.
Preferably, the magnetic cup is cylindrical, and the permanent magnet and the coil skeleton are annular.
Preferably, the end cover and the magnetic cup are provided with limit grooves, and the coil framework and the permanent magnet are arranged in the corresponding limit grooves.
Preferably, the magnetic cup further comprises a base, wherein the base is fixedly connected with the magnetic cup through interference fit or screw locking, and a containing cavity is formed between the base and the end cover.
Preferably, the middle section of the probe adapter is provided with a circle of protrusion, the protrusion is arranged in the accommodating cavity, and the protrusion is not contacted with the end cover and the base in the axial direction, so that the end cover and the base cannot interfere with the axial movement of the probe adapter and limit the axial position of the probe adapter.
Preferably, through holes for the probe adapter to pass through are formed in the end cover and the base, and the diameter of the through holes is larger than that of the probe adapter, so that the end cover and the base cannot obstruct the movement of the probe adapter and limit the radial position of the probe adapter.
Preferably, a groove is arranged at the upper end of the probe adapter, and the magnetostrictive material strip is clamped in the groove; the lower extreme of probe adapter is equipped with a blind hole, disposable probe chucking is in the blind hole.
Preferably, a chamfer for guiding the disposable probe is arranged at the opening of the blind hole.
The beneficial effects of the invention are as follows: 1) The magnetostriction material is used as a sensitive element, so that the response time of magnetostriction effect generated by the magnetostriction material is short, and the sensitivity of the magnetoelastic sensor is high; 2) The sensitive element is not in direct contact with the object to be measured, so that non-contact measurement is realized; 3) The elasticity of the object to be measured influences the resonance frequency, the viscosity influences the impedance amplitude, and the change of the elasticity of the object to be measured can be represented by detecting the resonance frequency and the impedance amplitude during resonance, so that the low-cost measurement is realized; 4) The probe is replaced once every detection, so that the probe does not need to be used for multiple times, and cross infection is avoided.
Drawings
FIG. 1 is an isometric view of a magnetoelastic sensor for measuring the viscoelastic force of blood according to the present invention;
FIG. 2 is a cross-sectional view of a magnetoelastic sensor for measuring the viscoelastic force of blood according to the present invention;
fig. 3 is a cross-sectional view of another magnetoelastic sensor for measuring the viscoelastic force of blood according to the present invention.
Detailed Description
The present invention is described in further detail below with reference to the drawings in conjunction with the examples to enable one skilled in the art to practice the same and to refer to the same.
The scheme provides two technical schemes about the magnetoelastic sensor. Referring to fig. 1 and 2, a magneto-elastic sensor for measuring blood viscoelasticity according to an embodiment of the present invention is shown, which comprises: a magnetic cup 10; a bobbin 102; a coil 103; a permanent magnet 104; a magnetostrictive material strip 101; a probe adapter 30; a disposable probe 40; end cap 50, and base 20.
The magnetic cup 10 is in a cylindrical shape and is in a hollow structure, an annular coil framework 102 and a permanent magnet 104 are coaxially arranged in the magnetic cup, the permanent magnet 104 is arranged on the outer side of the coil framework 102, a coil 103 is wound on the outer surface of the coil framework 102, when alternating current passes through the coil 103, an alternating magnetic field is generated inside the coil 103, the magnetostrictive material strip 101 is arranged at the central position of the magnetic cup 10 and is just positioned in the alternating magnetic field, the magnetostrictive material strip 101 generates axial telescopic vibration, the alternating magnetic field generated by the coil 103 can enable the magnetostrictive material strip 101 to vibrate at the frequency of 2 times of the alternating magnetic field according to the magnetic field-strain relation of the magnetostrictive material, and the frequency doubling effect can lead to low magnetic energy-mechanical energy conversion efficiency, reduce corresponding strain and influence measurement accuracy. The permanent magnet 104 generates a fixed bias magnetic field to make the magnetostrictive material strip 101 in a polarized state, when the bias magnetic field strength is set reasonably, the frequency doubling effect can be avoided, the telescopic vibration of the magnetostrictive material strip 101 and the applied alternating current are the same frequency, the magnetic energy-mechanical energy conversion efficiency can be improved, and a larger linear corresponding signal can be obtained. The permanent magnet 104 and the coil framework 102 are fixed in the magnetic cup 10 through one end cover 50, the end cover 50 and the magnetic cup 10 are provided with limiting grooves, and the coil framework and the permanent magnet are arranged in the corresponding limiting grooves.
A probe adapter 30 is arranged at the lower end of the magnetostrictive material strip 101, a groove is formed at one end of the probe adapter 30, which is contacted with the magnetostrictive material strip 101, the magnetostrictive material strip 101 is clamped in the groove to realize the fixed connection with the probe adapter 30, and the magnetostrictive material strip 101 can also realize the fixed connection with the probe adapter 30 through gluing. The other end of the probe adapter 30 is provided with a blind hole, the disposable probe 40 is clamped in the blind hole, the fixed connection with the probe adapter 30 is realized, a chamfer 302 is arranged at the opening of the blind hole, and the blind hole plays a certain guiding role when the disposable probe 40 is arranged. The magnetostrictive material strip 101 can drive the probe adapter 30 and the disposable probe 40 to axially move when axially vibrating in the gradient magnetic field.
The lower end of the sensor is further provided with a base 20, the base 20 and the magnetic cup 10 are fixedly connected through interference fit or screw locking, a containing cavity 60 is formed between the base 20 and the end cover 50, a circle of protrusions 301 are arranged at the middle section of the probe adapter 30, the protrusions 301 are arranged in the containing cavity 60, the protrusions 301 do not contact with the end cover 50 and the base 20 in the axial direction, through holes are formed in the base 20 and the end cover 50, the probe adapter 30 passes through the through holes, the diameter of the through holes is slightly larger than that of the probe adapter 30, the probe adapter 30 is not contacted with the end cover 50 and the base 20 in the radial direction, and the probe adapter 30 is suspended by the magnetostrictive material strip 101, so that when the magnetostrictive material strip 101 drives the probe adapter 30 to move, the base 20 and the end cover 50 do not interfere with the movement of the probe adapter 30, and meanwhile the base 20 and the end cover 50 also have mechanical limiting effects on the probe adapter 30 in the axial direction and the radial direction.
When the viscoelastic force measurement is carried out, the disposable probe is immersed into liquid or colloid to be measured, the object to be measured can directly influence the movement of the disposable probe, thereby indirectly influencing the resonance state of the magnetostrictive material strip, and the change of the viscoelastic force of the object to be measured can be obtained by measuring the related parameters.
The principle of detecting the viscoelastic force by using the magneto-elastic sensor is as follows: in an alternating magnetic field, the magnetostrictive material forms longitudinal periodic stretching vibration, and the resonance frequency and amplitude of the material are easily influenced by the surrounding environment. The core of the magnetostrictive sensor detection is to detect a change in the resonant state of the magnetostrictive material strip. The measurement of the magnetoelastic sensor adopts a frequency domain detection method based on impedance response from the point of signal detection. The impedance method relies on detecting the impedance change of the coil to realize resonance state detection, wherein a sweep frequency excitation signal is applied to the coil during detection, and then the voltage amplitude and the phase at two ends of the coil are detected to calculate the impedance of the coil. When the magnetostrictive material strip resonates, the real part of the impedance reaches a maximum. When the viscoelastic force measurement is carried out, the disposable probe is immersed into liquid or colloid to be measured, and the viscoelastic force of the object to be measured changes the resonance state of the magnetostrictive material strip: the elasticity of the object to be measured influences the resonance frequency; viscosity affects impedance magnitude. Therefore, the change of the viscoelasticity of the object to be detected can be characterized by detecting the resonance frequency and the change of the impedance amplitude during resonance.
The magneto-elastic sensor provided by the invention adopts the magnetostrictive material as the sensitive element, the response time of the magnetostrictive material for generating the magnetostrictive effect is short, and the sensitivity of the magneto-elastic sensor is high; the sensitive element is not in direct contact with the object to be measured, so that non-contact measurement is realized; the elasticity of the object to be measured influences the resonance frequency, the viscosity influences the impedance amplitude, and the change of the elasticity of the object to be measured can be represented by detecting the resonance frequency and the impedance amplitude during resonance, so that the low-cost measurement is realized; the probe is replaced once every detection, so that the probe does not need to be used for multiple times, and cross infection is avoided.
A second embodiment of the present invention is shown in fig. 3, which illustrates a magnetoelastic sensor for measuring the viscoelastic force of blood according to a real-time embodiment of the present invention, comprising a magnetic cup 10; a bobbin 102; a coil 103; a magnetostrictive material strip 101; a probe adapter 30; a disposable probe 40; end cap 50, and base 20. Compared with the former technical scheme, the permanent magnet in the first technical scheme is not needed, the bias magnetic field provided by the permanent magnet is realized by superposing a constant bias direct current on the basis of alternating current applied in the coil, and the structure, the position and the function of other components in the second technical scheme are the same as those in the first technical scheme. Compared with the first technical scheme, the magnitude of the bias magnetic field in the second technical scheme can be adjusted and controlled according to constant bias current, and the magnitude of the bias magnetic field is easier to control.
Although embodiments of the present invention have been disclosed above, it is not limited to the use of the description and embodiments, it is well suited to various fields of use for the invention, and further modifications may be readily apparent to those skilled in the art, and accordingly, the invention is not limited to the particular details without departing from the general concepts defined in the claims and the equivalents thereof.
Claims (5)
1. A magnetoelastic sensor for measuring the viscoelastic force of blood, comprising:
the magnetic cup is cylindrical and is of a hollow structure;
the coil framework is coaxially arranged in the magnetic cup, a coil is wound on the outer surface of the coil framework, a fixed bias magnetic field is arranged in the coil, the bias magnetic field is generated by a permanent magnet or is realized by superposing a constant bias direct current on the basis of alternating current applied in the coil, and the permanent magnet is coaxially arranged on the outer side of the coil framework;
an end cap for fixing the permanent magnet and the coil bobbin within the magnetic cup;
the base is fixedly connected with the magnetic cup through interference fit or screw locking, and a containing cavity is formed between the base and the end cover; a magnetostrictive material strip positioned at the center of the magnetic cup, just in the bias magnetic field;
the middle section of the probe adapter is provided with a circle of bulge, the bulge is arranged in the accommodating cavity, the bulge is not contacted with the end cover and the base in the axial direction, through holes are formed in the base and the end cover, the probe adapter penetrates through the through holes, and the diameter of the through holes is slightly larger than that of the probe adapter, so that the end cover and the base cannot interfere with the axial movement of the probe adapter;
one end of the probe adapter is fixedly connected with the magnetostrictive material strip, and the other end of the probe adapter is fixedly connected with a disposable probe so as to realize linkage of the three;
when alternating current passes through the coil, an alternating magnetic field is generated inside the coil, and when the bias magnetic field is reasonable in set strength, the frequency doubling effect can be avoided, the telescopic vibration of the magnetostrictive material strip and the applied alternating current can be the same frequency, the magnetic energy-mechanical energy conversion efficiency can be improved, and a larger linear corresponding signal can be obtained; the magnetostrictive material strip generates periodic axial telescopic vibration in the alternating magnetic field, the disposable probe is immersed into an object to be measured, and the viscoelasticity of the object to be measured changes the vibration state of the magnetostrictive material strip.
2. The magnetoelastic sensor for measuring the viscoelastic force of blood according to claim 1, wherein the magnetic cup is cylindrical, and the permanent magnet and the coil bobbin are annular.
3. The magnetoelastic sensor for measuring the viscoelastic force of blood according to claim 1, wherein the end cap and the magnetic cup are provided with a limit slot, and the coil bobbin and the permanent magnet are disposed in the corresponding limit slot.
4. The magnetoelastic sensor for measuring the viscoelastic force of blood according to claim 1, wherein the upper end of the probe adapter is provided with a groove, and the magnetostrictive material strip is clamped in the groove; the lower extreme of probe adapter is equipped with a blind hole, disposable probe chucking is in the blind hole.
5. The magnetoelastic sensor for measuring the viscoelastic force of blood according to claim 4, wherein a chamfer for guiding the disposable probe is provided at the opening of the blind hole.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710806699.4A CN107525744B (en) | 2017-09-08 | 2017-09-08 | Magnetoelastic sensor for measuring blood viscoelasticity |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710806699.4A CN107525744B (en) | 2017-09-08 | 2017-09-08 | Magnetoelastic sensor for measuring blood viscoelasticity |
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| CN107525744A CN107525744A (en) | 2017-12-29 |
| CN107525744B true CN107525744B (en) | 2024-02-09 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108318699B (en) * | 2018-04-12 | 2024-03-12 | 赫安仕科技（苏州）有限公司 | Blood cup assembling and disassembling device and assembling and disassembling method thereof |
| CN109060601A (en) * | 2018-09-21 | 2018-12-21 | 世纪亿康（天津）医疗科技发展有限公司 | A kind of sensor and viscosimeter |
| CN114383697A (en) * | 2021-12-28 | 2022-04-22 | 太原智林信息技术股份有限公司 | Electronic balance based on magnetostrictive sensor |
| CN114674713B (en) * | 2022-05-26 | 2022-08-30 | 中国科学院苏州生物医学工程技术研究所 | Blood viscoelasticity measuring method |
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| CN102025288A (en) * | 2010-11-26 | 2011-04-20 | 大连理工大学 | Giant magnetostrictive actuator with permanet torque output and control method thereof |
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| CN104049029A (en) * | 2014-07-02 | 2014-09-17 | 重庆大学 | Multi-channel magneto-elastic sensor detection chip |
| CN207366399U (en) * | 2017-09-08 | 2018-05-15 | 中国科学院苏州生物医学工程技术研究所 | The magnetoelastic sensor of elastic force is sticked for measuring blood |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060010963A1 (en) * | 2003-10-15 | 2006-01-19 | Bach David T | Measurement of viscosity using magnetostrictive particle sensors |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101231314A (en) * | 2008-02-21 | 2008-07-30 | 湖南大学 | Method and apparatus for testing magnetosensor resonant frequency elasticity |
| CN102025288A (en) * | 2010-11-26 | 2011-04-20 | 大连理工大学 | Giant magnetostrictive actuator with permanet torque output and control method thereof |
| CN103105591A (en) * | 2013-01-22 | 2013-05-15 | 重庆大学 | Zero-bias magnetic sensor probe |
| CN103674991A (en) * | 2013-11-19 | 2014-03-26 | 太原理工大学 | Body fluid cancer marker detection device for human body |
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