CN102809597A - Liquid resonance sensing method and system - Google Patents

Liquid resonance sensing method and system Download PDF

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CN102809597A
CN102809597A CN 201210299613 CN201210299613A CN102809597A CN 102809597 A CN102809597 A CN 102809597A CN 201210299613 CN201210299613 CN 201210299613 CN 201210299613 A CN201210299613 A CN 201210299613A CN 102809597 A CN102809597 A CN 102809597A
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liquid
frequency
resonance
change
system
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CN 201210299613
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刘盛平
周奇
陈国明
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重庆理工大学
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Abstract

The invention discloses a liquid resonance sensing method and a system. The properties such as liquid viscoelasticity, density, composition, concentration and the like can be represented by liquid inherent frequency; liquid can generate resonance under the function of an alternating incentive oscillation signal; the resonance frequency changes accordingly when the liquid properties change; a sensor is a gold-film plated interdigital micro electrode and can be used for detecting the change of the liquid resonance frequency caused by the change of liquid viscoelasticity, density, composition and concentration; and specificity detection on a biochemical substance can be realized if the gold-film is modified with a biochemical function molecule. The sensing system consists of a resonance sensor 101, a driving oscillator 102, a vibration pickup 103, a single-chip microcomputer 104 and a computer 105. The system is simple in structure, can simultaneously detect the frequency change and the amplitude change of the sensor and an incentive response signal dynamic dissipative wave, and realize high accuracy and reliable detection of the liquid physical and chemical properties.

Description

液体谐振传感方法及系统 Method and system for sensing the liquid resonance

技术领域 FIELD

[0001] 本发明属于传感技术、生化及物理技术领域,具体涉及一种液体谐振传感方法及系统。 [0001] The present invention belongs to the sensing technology, biochemistry and physical techniques, and in particular, to a method and system for sensing a liquid resonance.

背景技术 Background technique

[0002] 谐振是一种广泛存在的现象,在机械、化学、光、电和磁系统及其之间相互能量转换过程的系统中均可以观察到谐振现象。 [0002] The resonance is a widespread phenomenon, each energy conversion system between mechanical, chemical, optical, electrical and magnetic system and the process can be observed in the resonance phenomenon. 迄今,人们建立了气态和固态物质的谐振理论,并广泛应用。 So far, it has established resonance theory gaseous and solid material, and widely used. 为了认识液体的性质,当前人们采用密度、浓度、PH值、粘弹性、电导率和介电常数等参数从不同角度对液体进行表征,而对于液体中的非平衡过程则常用布朗运动和涨落等进行描述。 In order to understand the nature of the liquid, it uses the current density, concentration, PH, viscoelasticity, dielectric constant and conductivity parameters characterizing the liquid from different angles, and for non-equilibrium liquid in the process of Brownian motion and fluctuation common and so on are described. 任何液体都是由极性分子或非极性分子组成,且分子在相对应的平衡位置附近振荡,其振荡频率与其“内在性质”——粘弹性、密度、介电常数、成分及浓度等参数有关,因此振荡频率表征着液体的综合内在性质。 Any liquid molecules are polar or non-polar molecules and the molecules to oscillate around the equilibrium position corresponding to the oscillation frequency and its "intrinsic property" - viscoelasticity, density, dielectric constant, and component concentration parameters , and therefore the oscillation frequency of the comprehensive characterization of the intrinsic properties of the liquid. 若在液体中置入两个电极,且施加以交变激励电压,液体分子振荡会随外加交变电压的作用而变化。 When two electrodes placed in the liquid, and to the alternating excitation voltage applied to the liquid molecules with the oscillations of the alternating voltage applied is changed. 在一般情况下,液体分子的振幅幅值非常微小,但当外加交变电压的频率与液体分子固有振荡频率相同时,贝1J液体分子的振幅明显加大,比其它频率下的振幅大得多,这种现象我们称为“液体谐振”,它与LC回路的谐振现象有相似之处。 In general, the magnitude of the amplitude of the liquid molecules is very small, but the frequency of the applied alternating molecules of the liquid natural oscillation frequency of the same voltage amplitude 1J shell liquid molecules significantly increased, other than the amplitude at a frequency much greater this phenomenon we call "liquid resonance", a phenomenon which the LC resonance circuit are similar. 液体的“内在性质”不变时,那么它的振荡频率是一定的。 "Inherent nature" liquid time-invariant, then its oscillation frequency is constant. 如果液体任一性质发生变化,则这时的液体已经不是“原来液体”了,其振荡频率一定会发生变化,它是液体性质变化的综合反应。 If any of the changing nature of the liquid, the liquid at this time is not the "original liquid", and the oscillation frequency will vary, it is an integrated reaction liquid properties change. 液体的振荡频率的变化后,可用特定设计的电极,通过设计相应的检测系统可以进行谐振频率测量。 After the change in the oscillation frequency of the liquid, available electrodes particular design, the resonance frequency can be measured by appropriate design of the detection system. 由此,在一个封闭的环境下,当液体其它参数(如介电常数、电导率、密度、PH值等)固定,只让某一个参数变化,则采用结构特征参数确定的特定电极,可获得由于液体某一参数(如粘弹性)变化而引起的液体谐振频率的变化,从而可用谐振频率来表征液体“内在性质”的改变。 Thus, in a closed environment, when a liquid other parameters (such as dielectric constant, electrical conductivity, density, PH value, etc.) is fixed, so that only certain parameters, using a specific electrode structure characteristic parameters determined is obtained Since the resonance frequency changes of the liquid parameters of a fluid (e.g., viscoelastic) caused by the change, so that the resonance frequency can be used to characterize the change of liquid "intrinsic property" of. 由于液体分子间的相互作用比固体小得多,所以液体固有频率更易受到液体“内在性质”变化的影响,引起自身频率较大变化,比其作用于压电晶体而引起压电晶体频率变化要大得多。 Due to the interaction between the liquid molecules is much smaller than the solids, the liquid is more susceptible to natural frequency "intrinsic property" changes in the liquid, cause large changes in their frequency, than acting on piezoelectric crystal due to the frequency change of the piezoelectric crystal It is much greater. 因此,从理论上来说,用液体谐振频率来表征液体性质变化具有更高的灵敏度。 Thus, theoretically, the resonant frequency of the liquid characterized by a liquid having a higher sensitivity property change. 由此,本发明提出一种基于液体谐振机理的传感方法及系统。 Thus, the present invention provides a sensing method and a system based on liquid resonance mechanism.

发明内容 SUMMARY

[0003] 本发明的目的在于针对医学临床检测的需求,提供一种新型的液体谐振传感方法与系统。 [0003] The object of the present invention is the medical needs of clinical testing, to provide a novel method and system for sensing a liquid resonance. 液体谐振传感方法基于液体谐振特性而建立,利用液体谐振频率来表征液体“内在性质”的变化,即液体粘弹性、密度、介电常数、成分及浓度等参数的变化。 Liquid resonant sensing method established based on the resonance characteristics of the liquid, the change of parameters used to characterize liquid "intrinsic property" of the resonance frequency variation with liquid, i.e. a viscoelastic liquid, density, dielectric constant, and the component concentration. 液体谐振传感系统由谐振传感器、信号激励振荡模块、信号采集及处理模块及计算机构成。 Liquid sensing system resonance excited by the resonance oscillation sensor module, a signal, the signal acquisition and processing module and the computer configuration. 系统利用谐振传感器201作为敏感单元,激励振荡器102给谐振传感器施加特定的激励振荡信号,激励信号与液体固有频率产生谐振,拾振器103获取谐振信号,其相应硬件电路获取谐振信号的频率和幅度特征,将频率信号直接传送给单片机104,单片机104在标准秒信号控制下,在所编写的程序控制下,利用计时器/计数器即可获得频率信号的频率值(Hz);另一方面,对于信号幅度特征,通过信号调理转换成电压信号,通过a/d转换器转换成数字信号输入到单片机104。 System utilizes resonant sensor as the sensing means 201, the excitation oscillator 102 is applied to a specific excitation signal oscillating resonant sensor, the excitation signal with the liquid natural frequency of resonance, the vibration pickup 103 acquires resonance signal, the frequency of the corresponding resonance signal acquisition hardware and wherein the amplitude of the frequency signal is transmitted directly to the microcontroller 104, the microcontroller 104 controls the second signal in the standard, the written under program control, to obtain the frequency value (Hz) of the frequency signal using the timer / counter; on the other hand, wherein the amplitude of the signal, into a voltage signal by the signal conditioning converter converts by a d / a digital signal input to the microcontroller 104. 单片机104的处理结果送液晶显示器实时显示,并保存相应结果到存储单元,也可通过无线接口传送至计算机105供进一步处理分析、显示、存储和远程共享等。 Processing result 104 MCU send real-time display of the liquid crystal display, and the corresponding result stored in the storage unit, may be transferred to a computer via a wireless interface 105 for further processing and analysis, display, storage and remote sharing. 激励振荡器102发送的激励振荡信号可根据拾振器及单片机结果进行调整。 Excitation oscillation excitation signal transmitted by the oscillator 102 can be adjusted according to the results of the vibration pickup and SCM.

[0004] 本发明的技术方案如下: [0004] aspect of the present invention is as follows:

[0005] 液体谐振传感器是在一绝缘基地上制作一叉指型电极(阵列)201,电极表面镀金膜,该金膜的厚度约为50-200nm。 [0005] Liquid resonant sensor is making a interdigital electrodes (array) on an insulating base 201, gold-plated film surface of the electrode, the thickness of the gold film of about 50-200nm. 叉指电极对的单电极可等效为二阶串联谐振系统,其等效电路模型为包含一个电阻R、电感L和电容C的电路,那么传感器固有频率为GJci= I/(LC)1气液体粘弹性、密度、介电特性等物理特性或液体成分及其浓度等发生变化,使得液体的电特性产生相应变化,最终综合表现为液体固有频率的变化。 Single electrode of the interdigital electrode may be equivalent to a series resonant second order system, the equivalent circuit model comprises a resistance R, inductance L and capacitance C of the circuit, the natural frequency of the sensor GJci = I / (LC) 1 gas physical properties of the liquid viscoelastic, density, dielectric properties and the like or a liquid component concentration changes, so that the electrical characteristics of the liquid produces a corresponding change in the final overall performance liquid natural frequency changes. 则当激励信号频率ω =ω0时,液体产生谐振现象,其谐振频率及幅度等参数通过外电路进行检测。 When the excitation signal frequency ω = ω0, the liquid resonance phenomenon, its resonance frequency and amplitude parameters detected by an external circuit. 为了提高传感器对特定生化成分或生物分子的选择性和灵敏度,可在金膜上再固化一层对化学成分或生物分子具有高度特异性结合的敏感层。 In order to increase the specific biochemical component or sensor selectivity and sensitivity of biomolecules, can be re-solidified layer having a gold film layer highly sensitive specific binding of the chemical composition or biological molecules.

[0006] 本发明所涉及的液体谐振传感方法及系统利用液体谐振原理,基于液体物理化学特性的改变而弓I起的液体固有频率的变化,通过施加特定的激励振荡信号使液体产生谐振,通过获得液体谐振频率来实时检测液体的理化性质。 [0006] Liquid resonant sensing method and system according to the present invention using a liquid resonance principle, based on changes in physical and chemical properties of the liquid natural frequency changes of the liquid bow I plays the liquid by application of a specific resonance excitation oscillation signal, the liquid obtained by real-time detection resonant frequency of the physical and chemical properties of the liquid. 相对现有检测技术,本发明灵敏度更高,检测方法更为简单。 Detecting the relative prior art, the present invention is more sensitive detection method is simpler. 针对传感器阵列,结合多传感器信息融合技术,易于实现多参数理化性质的检测。 For the sensor array, in conjunction with multi-sensor data fusion technology, easy to realize multi-parameter detection physicochemical properties. 传感系统检测快速、方便,不仅可应用于液体粘弹性、密度、介电常数等物理参数的检测,如血液疾病及心脑血管疾病病人的血液凝血过程血液粘弹性变化的实时、在体连续监测,亦可在传感器电极表面修饰不同的功能分子,实现对各种疾病标志物生化分子的特异性检测。 Sensing detection system quickly and easily, it can be applied not only to detect a physical parameter viscous liquid elastomer, density, dielectric constant, such as the blood clotting process elastic change in blood viscosity and blood diseases cardiovascular disease patient in real time, continuous in vivo monitoring, different functional molecules can also be modified on the electrode surface of the sensor, to achieve specific detection of various disease marker biological molecule. 传感系统获得的信号数据具有多种信息参数,如频率、幅值、受激励后传感器的激励响应信号动态耗散波等,均可由单片机、计算机进行分析计算。 Data obtained signal sensing system having a plurality of information parameters, such as frequency, amplitude, excited after the excitation signal dynamic response of the sensor dissipative wave, can be analyzed and calculated by the microcontroller, computer. 这些不同信息参数受液体粘弹性、密度、介电常数等物理特性以及生化物质成分和浓度等的影响,具有不同的响应结果和关联性,是多维信息,通过对这多维信息的处理和分析,用其中任意一维信息都可获得相应的物理或化学参数。 These various information parameters affected by the physical properties of viscoelastic liquids, density, dielectric constant and the concentration and composition of biochemical substances having different responses and correlation results, a multi-dimensional information, this multi-dimensional information by processing and analysis, wherein any of the one-dimensional information are available to the respective physical or chemical parameters.

附图说明 BRIEF DESCRIPTION

[0007] 图I为传感系统结构示意图 [0007] Figure I is a schematic view of the structure of the sensing system

[0008] 图中101为谐振传感器;102为激励振荡器;103为拾振器;104为单片机;105为计算机; [0008] FIG. 101 is a resonant sensor; excitation oscillator 102; 103 vibration pickup; for the microcontroller 104; 105 computer;

[0009] 图2为谐振传感器结构示意图 [0009] FIG. 2 is a schematic view of a resonant sensor structure

[0010] 图中201为电极阵列的单个叉指电极;202为叉指电极接口。 [0010] FIG finger electrode 201 as a single prong of the electrode array; 202 interfaces to the interdigital electrode.

[0011] 图3为激励振荡及信号采集模块示意图 [0011] FIG. 3 is a schematic diagram of the oscillation excitation and signal acquisition module

[0012] 图中301为运算放大器;302为谐振传感器;303为单片机;304为控制标准秒信号电路;305为无线接口;306为Flash闪存;307为液晶显示器(IXD)。 [0012] FIG. 301 is an operational amplifier; resonant sensor 302; the microcontroller 303; 304 seconds for the standard control signal circuit; a wireless interface 305; 306 Flash memory; 307 a liquid crystal display (IXD).

具体实施方式 detailed description

[0013] 下面结合附图对本发明的具体实施做进一步的描述。 [0013] The following figures further description of specific embodiments of the present invention binds.

[0014] 谐振电极阵列由8个叉指型梳状电极201和电极接口202构成。 [0014] The resonator electrode array consists of eight interdigital electrode comb electrodes 201 and the interface 202. 激励振荡模块由高速集成运算放大器301以及电阻(R1、R2、R3、R4)、电容(C1、C2)等组成,其中R1、R4分别与电源VCC相连,R2,Cl,R3分别与高速集成运算放大器的1,2,3脚相连,谐振传感器302与电容C2串联在电路中形成振荡,然后输出具有TTL电平的频率信号。 Excited oscillation module by the integrated high-speed operational amplifier 301 and resistors (R1, R2, R3, R4), the capacitor (C1, C2) and other components, wherein R1, R4 is connected to power supply VCC, respectively, R2, Cl, R3 respectively integrated high-speed operation 1,2,3 foot amplifier is connected to the resonance sensor 302 and the capacitor C2 are connected in series to form a resonance circuit, and then outputs a frequency signal having a TTL level. 此电路设计使得谐振传感器系统在全液相条件下仍能振荡。 This circuit is designed so that the resonance oscillation in the sensor system is capable of full-liquid phase conditions. 当液体理化性质发生变化时,液体的固有频率将会随之变化,调整激励振荡信号的频率,使其能与液体固有频率产生谐振,谐振频率信号进入单片机303的中断O 口,而标准秒信号的闸门时间通过单片机303的中断I 口进入,通过控制标准秒信号电路304的闸门时间,单片机303对频率振荡模块输出的频率进行检测,同时通过获取A/D转换器结果实现对其它信号的检测,检测结果送液晶显示器307实时显示, 同时保存于Flash闪存306中,也可通过单片机通讯口传送给无线接口305,然后通过无线口实时发送至计算机做进一步处理、分析、显示、存储和远程共享等。 Physical and chemical properties when a liquid changes, the natural frequency will change with the liquid, adjusting the excitation frequency of the oscillation signal, so that it can resonate with the natural frequency of the liquid, the resonance frequency signal into the microcontroller interrupt O port 303, and the second standard signal gate time by the microcontroller 303, interrupt I into the mouth, the microcontroller frequency 303 of the frequency of the oscillation module output is detected by a control standard second signal circuit 304 of the gate time, while enabling detection of other signals by obtaining the a / D converter results , the detection results sent to the liquid crystal display 307 in real time display, and stored in the Flash memory 306 may also be through the MCU communication port to the wireless interface 305, and then transmitted via the wireless port in real-time to a computer for further processing, analysis, display, storage and remote sharing Wait.

Claims (3)

  1. 1.液体谐振传感方法及系统,其特征在于:设置一镀金膜叉指微电极阵列谐振传感器,设计相应的激励振荡电路,基于液体谐振原理,利用频率采集电路获得谐振频率特性,直接送入单片机系统,经过单片机处理后,通过无线通讯接口传送到计算机,利用谐振频率的变化与液体固有特性间的关系,获得液体粘弹性、密度、成分及其浓度等特性参数。 1. Liquid resonant sensing method and system, wherein: a plated film disposed interdigitated microelectrode array resonant sensor, the excitation oscillation circuit design appropriate, based on the principle of resonance liquid, obtained by the frequency acquisition circuit resonance frequency characteristics, directly into SCM system, the microcontroller after treatment, transferred to a computer via the wireless communication interface, using the relation between the liquid and the change in the natural resonance frequency characteristics obtained liquid viscoelastic parameters, density, composition and concentration.
  2. 2.根据权利要求I所述的液体谐振传感方法及系统,其特征在于:液体粘弹性、密度、介电常数等性质可由液体固有频率来表征,在激励振荡电路施加的交变信号作用下,液体产生谐振,当液体性质变化时,其谐振频率会发生相应变化,测量谐振传感器的振荡响应,利用过零检测电路将该响应信号整形成方波输出,然后利用频率测量电路进行频率测量,也可通过系统的信号调理电路获得谐振信号的幅度特性。 2. The liquid sensing resonator method and system according to claim I, wherein: the viscoelastic properties of the liquid, density, dielectric constant, etc. may be characterized by the natural frequency of the liquid, acting under alternating excitation signal applied to the oscillation circuit , liquid resonance, when the liquid properties change, which changes the resonant frequency accordingly, measuring the oscillatory response of the resonant sensor, using over-the square wave shaped signal in response to the output of zero detector circuit, and then using a frequency measuring circuit for measuring the frequency, It may also be obtained amplitude characteristic resonance signal by the signal conditioning circuitry.
  3. 3.根据权利要求I所述的液体谐振传感方法及系统,其特征在于:在金膜上修饰对生物分子或化学成分有特异性结合的功能分子,可测量功能分子与待测成分结合并施加激励振荡信号后输出响应信号的频率及动态耗散波,实现对生化分子的特异性检测。 The liquid resonant sensing method and system according to claim I, wherein: the modified gold film functional molecule specifically binding to a biomolecule or chemical composition, functional measure and test molecule binds ingredient in response to the output signal frequency of the wave and dissipation of dynamic oscillation excitation signal is applied, to achieve specific detection of biological molecules.
CN 201210299613 2012-08-22 2012-08-22 Liquid resonance sensing method and system CN102809597A (en)

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