CN107519272B - 一种含盐中药足浴泡腾片及其制备方法 - Google Patents
一种含盐中药足浴泡腾片及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种含盐中药足浴泡腾片及其制备方法,以氯化钠、硫酸钠、硫酸锌、硼砂、中药提取物、季铵盐微囊、精油微囊、黏结剂、泡腾剂、润滑剂为主要成分,通过对中药有效成分提取,将具有杀菌、止痒的脂溶性季铵盐及精油进行微囊包合,易于泡腾片的制备,同时达到缓释作用。该方法制备的泡腾片由于其中的中药提取物、季铵盐及精油具有杀菌效能高、杀菌能力强,无机盐复配具有强杀真菌能力,中药配方合理,各成分协同作用,不仅具有缓解疲劳,还能排除人体内的毒素、增加血液循环,有效的抑制、杀灭脚上的真菌,起到抗菌止痒、敛汗止汗的作用,起效快,疗程短,无毒副作用,无依赖性。本发明产品使用方便、稳定、安全、绿色环保。
Description
技术领域
本发明属于日用化工技术领域,具体是涉及一种利用无机盐与中药提取物复配的足浴泡腾片。本发明同时还涉及一种制备所述足浴泡腾片的优选方法。
背景技术
足浴保健是传统的保健方法,通过中药泡脚可以改善血液循环,药物经足部“透皮吸收”后“双向调节”血液系统和神经系统。前者,行气活血,促进新陈代谢,活化器官功能。以脚部为人体“第二心脏”,可全面激活人体大循环,清除血液垃圾和体内老化的自由基,促进体内各器官的供血情况;后者,通过刺激穴位和反射区,通经活络,平衡阴阳,使身体经脉内连脏腑,外络肢节,整个机体紧密连系在一起,滋养大脑驱体与全身神经的协和运行,从而达到检测、治疗、综合调理、辅助康复的防病治病目的。并通过微微出汗,加快机体各种代谢废物、各种毒素的有效排泄,减轻或消除外来之毒、内生之毒对人体健康的危害,从而起到养生保健作用。足浴产品的效果是否理想主要取决于配方和剂型。
现代社会中很多人易受足病的困扰,其中的大多数足病为真菌感染。发明专利(申请号201410257463.6)公开了一种杀灭脚气细菌、真菌兼有养生功效的中药泡腾片及制作方法,将中药直接与泡腾剂组合制作泡腾片;公布号CN103656629A的中国专利文献公开了含有海洋生物杀菌成分的足浴泡腾片及其制备方法;公布号CN 104547991的中国专利文献公开了一种足浴泡腾片及其制备方法。这些技术用到了中药及各种杀菌剂,制备足浴泡腾片。但现有技术还存在中药有效成分利用率低、产品杀菌单一、效果欠佳的缺点。
盐的特征是性能稳定,具有清洁、消毒、消炎、止痒、防腐等作用,足浴盐的研制就是利用盐的这些作用,以盐为主要成份和载体,复配其它足部皮肤治疗、保健药物,可以增强产品的消毒、止痒、除脚臭等功效。研究结果表明,氯化钠复配硫酸锌及硼砂具有较好的杀真菌效果,同时硫酸锌还有收敛作用。但现有技术中尚未见有以盐为载体、包含季胺盐微囊的中药足浴泡腾片产品。
发明内容
本发明的目的在于针对现有技术的不足,提供一种杀菌、止痒性能优异、可杀灭多种真菌、安全性高的含盐中药足浴泡腾片。
本发明的目的还在于提供一种制备所述含盐中药足浴泡腾片的优选方法。
本发明的目的通过以下技术方案予以实现。
除非另有说明,本发明所采用的百分数均为重量百分数。
一种含盐中药足浴泡腾片,由下述重量份的原料制成:氯化钠25~35份,中药乙醇提取物0.5~3份,季铵盐微囊5~10份,精油微囊2~5份,黏结剂5~10份,泡腾剂35~70份,硫酸钠10~15份,硫酸锌1~3份,硼砂0.5~3份和润滑剂1~3份;
其中,所述的中药乙醇提取物为:苦参12~15份、艾叶10~20份、川穹10~15份、鸡血藤8~15份、穿心莲8~12份、白鲜皮5~10份、甘草15~20份、薄荷16~20份和苍术14~16份,混合后的乙醇提取物。
所述的季铵盐为十二烷基二甲基苄基溴化铵、双烷基甲基羟乙基溴化铵、2-(2-羟乙基)-甲基-(1-甲基-咪唑-2-亚甲基)氯化铵、或烷基二苄醚双氯化铵中的一种。
所述的精油为薰衣草精油、茶树精油、尤加利精油、香茅精油、佛手柑精油、鼠尾草精油或松针精油中的一种。
所述的黏结剂选自聚乙烯醇、共聚维酮、聚乙烯吡咯烷酮、或羧甲基纤维素钠中一种。
所述的泡腾剂由酸源和二氧化碳源组成,酸源为己二酸、琥珀酸、戊二酸、或氨基三乙酸中一种;酸源用量15~30份;二氧化碳源为碳酸钠、碳酸氢钠、或过碳酸钠中的两种或三种;二氧化碳源用量20~40份。
所述的润滑剂选自硬脂酸镁或滑石粉中的一种。
制备所述含盐中药足浴泡腾片的方法,包括以下步骤:
(1)中药乙醇提取物制备:按重量份称取苦参12~15份、艾叶10~20份、川穹10~15份、鸡血藤8~15份、穿心莲8~12份、白鲜皮5~10份、甘草15~20份、薄荷16~20份和苍术14~16份,加入10~20倍量的75%乙醇浸泡30~40min,加热回流1~2h提取2~3次,合并提取液,浓缩、干燥,粉碎过20目筛,得中药乙醇提取物备用;
(2)季铵盐微囊制备:取季铵盐加等量95%乙醇稀释,并加入环糊精和蒸馏水混合均匀,用胶体磨研磨成糊状物、减压抽滤,用无水乙醇洗涤,沉淀物干燥得季铵盐微囊备用;
(3)精油微囊制备:取精油加等量95%乙醇稀释,并加入环糊精和蒸馏水混合均匀,用胶体磨研磨成糊状物、减压抽滤,用无水乙醇洗涤,沉淀物干燥得精油微囊备用;
(4)泡腾片制备:
称取中药乙醇提取物0.5~3份、季铵盐微囊5~10份、精油微囊2~5份、泡腾剂酸源15~30份、氯化钠25~35份、硫酸钠10~15份、硫酸锌1~3份、硼砂0.5~3份,混合均匀;过20目筛,整粒;再加入泡腾剂二氧化碳源20~40份、黏结剂5~10份及润滑剂1~3份,混匀,干燥、压片,制得所需含盐中药足浴泡腾片。
步骤(2)中,所述的季铵盐与环糊精的质量比为1:3~6,环糊精为β-环糊精或羟丙β-环糊精中之一种;环糊精与蒸馏水的质量比为1:3~6。
步骤(3)中,所述的精油与环糊精的质量比为1:3~6,环糊精为β-环糊精或羟丙β-环糊精中之一种;环糊精与蒸馏水的质量比为1:3~6。
步骤(2)和步骤(3)中,所述的研磨时间为15~25min,
所述的干燥均采用常规的真空干燥或鼓风干燥。
相对于现有技术,本发明具有以下优点:
1、本发明通过对中药有效成分提取,将具有杀菌、止痒的脂溶性季铵盐及精油进行微囊包合,易于泡腾片的制备,同时达到缓释作用。
2、泡腾片配方中的中药提取物、季铵盐及精油具有杀菌效能高、杀菌能力强的特点,再复配无机盐后各成分协同作用,不仅具有缓解疲劳,还能排除人体内的毒素、增加血液循环,有效的抑制、杀灭脚上的真菌,起到杀菌抗菌、消毒、消炎、止痒、敛汗止汗、调节体内循环等作用。
3、该产品起效快,疗程短,无毒副作用,无依赖性。使用方便、稳定、安全、绿色环保。
具体实施方式
下面通过实施例对本发明作进一步地详细说明,但实施例并不是对本发明技术方案的限定。所有基于本发明教导所做出的变化或等同替换均应属于本发明的保护范围。
实施例1:
(1)中药乙醇提取物的制备:按苦参12g、艾叶10g、川穹10g、鸡血藤8g、穿心莲8g、白鲜皮5g、甘草15g、薄荷16g、苍术14g,加入900mL75%乙醇浸泡30min,加热回流1h提取3次,合并提取液,经常规喷雾干燥,粉碎过20目筛,得中药乙醇提取物。
(2)季铵盐微囊制备:100g十二烷基二甲基苄基溴化铵中加100g 95%乙醇,加入300g环糊精及900g蒸馏水混合均匀,用胶体磨研磨20min,减压抽滤,用无水乙醇洗涤包合物,于45℃鼓风干燥箱干燥,得300g包合物,即十二烷基二甲基苄基溴化铵微囊。
(3)薰衣草精油微囊制备:100g薰衣草精油中加100g 95%乙醇,加入300g环糊精及900g蒸馏水混合均匀,用胶体磨研磨15min,减压抽滤,用无水乙醇洗涤包合物,于45℃鼓风干燥箱干燥,得290g包合物,即薰衣草精油微囊。
(4)中药足浴泡腾片制备:
①称取5g十二烷基二甲基苄基溴化铵微囊、2g薰衣草精油微囊、0.5g中药乙醇提取物、15g己二酸、35g氯化钠、10g硫酸钠、1g硫酸锌,0.5g硼砂混合均匀;
②颗粒过20目筛,整粒;
③将20g碳酸钠、1g滑石粉及5g聚乙烯醇到步骤(2)的颗粒中,混匀,压片,制得中药足浴泡腾片。
实施例2:
(1)中药乙醇提取物的制备:按苦参15g、艾叶20g、川穹15g、鸡血藤15g、穿心莲12g、白鲜皮10g、甘草20g、薄荷20g、苍术16g,加入2860mL 75%乙醇浸泡40min,加热回流2h提取2次,合并提取液,经50℃真空干燥24h,粉碎过20目筛,得中药乙醇提取物。
(2)双烷基甲基羟乙基溴化铵微囊制备:100g双烷基甲基羟乙基溴化铵中加100g95%乙醇,加入400g羟丙β-环糊精及2000g蒸馏水混合均匀,用胶体磨研磨25min,减压抽滤,用无水乙醇洗涤包合物,于50℃真空干燥箱干燥24h,得360g包合物,即双烷基甲基羟乙基溴化铵微囊。
(3)茶树精油微囊制备:100g茶树精油中加100g 95%乙醇,加入400g羟丙β-环糊精及2000g蒸馏水混合均匀,用胶体磨研磨25min,减压抽滤,用无水乙醇洗涤包合物,于50℃真空干燥箱干燥24h,得365g包合物,即茶树精油微囊。
(4)中药足浴泡腾片制备:
①称取7g双烷基甲基羟乙基溴化铵微囊、3g茶树精油微囊、1g中药乙醇提取物、20g琥珀酸、25g氯化钠、12g硫酸钠、2g硫酸锌,1g硼砂混合均匀;
②颗粒过20目筛,整粒;
③将20g碳酸钠、10g过碳酸钠、1g硬脂酸镁及6g共聚维酮到步骤②的颗粒中,混匀,压片,制得中药足浴泡腾片。
实施例3:
(1)中药乙醇提取物的制备:按苦参13g、艾叶17g、川穹12g、鸡血藤10g、穿心莲10g、白鲜皮8g、甘草17g、薄荷18g、苍术15g,加入1800mL 75%乙醇浸泡35min,加热回流1.5h提取2次,合并提取液,经常规喷雾干燥,粉碎过20目筛,得中药乙醇提取物。
(2)2-(2-羟乙基)-甲基-(1-甲基-咪唑-2-亚甲基)氯化铵微囊制备:100g2-(2-羟乙基)-甲基-(1-甲基-咪唑-2-亚甲基)氯化铵中加100g 95%乙醇,加入600g羟丙β-环糊精及3600g蒸馏水混合均匀,用胶体磨研磨25min,减压抽滤,用无水乙醇洗涤包合物,于50℃鼓风干燥箱干燥,得495g包合物,即2-(2-羟乙基)-甲基-(1-甲基-咪唑-2-亚甲基)氯化铵微囊。
(3)尤加利精油微囊制备:100g茶树精油中加100g 95%乙醇,加入400g羟丙β-环糊精及2000g蒸馏水混合均匀,用胶体磨研磨25min,减压抽滤,用无水乙醇洗涤包合物,于50℃鼓风干燥箱干燥,得490g包合物,即尤加利精油微囊。
(4)中药足浴泡腾片制备:
①称取8g2-(2-羟乙基)-甲基-(1-甲基-咪唑-2-亚甲基)氯化铵微囊、2g尤加利精油微囊、2g中药乙醇提取物、20g戊二酸、30g氯化钠、14g硫酸钠、3g硫酸锌,2g硼砂混合均匀;
②颗粒过20目筛,整粒;
③将12g碳酸钠、10g碳酸氢钠、6g过碳酸钠、2g硬脂酸镁及10g聚乙烯吡咯烷酮到步骤②的颗粒中,混匀,压片,制得中药足浴泡腾片。
实施例4:
(1)中药乙醇提取物的制备:按苦参14g、艾叶15g、川穹10g、鸡血藤12g、穿心莲10g、白鲜皮7g、甘草15g、薄荷20g、苍术15g,加入1500mL 75%乙醇浸泡35min,加热回流2h提取2次,合并提取液,经50℃真空干燥箱干燥40h,粉碎过20目筛,得中药乙醇提取物。
(2)烷基二苄醚双氯化铵微囊制备:100g2-(2-羟乙基)-甲基-(1-甲基-咪唑-2-亚甲基)氯化铵中加100g 95%乙醇,加入500g环糊精及2500g蒸馏水混合均匀,用胶体磨研磨15min,减压抽滤,用无水乙醇洗涤包合物,于50℃真空干燥箱干燥40h,得400g包合物,即烷基二苄醚双氯化铵微囊。
(3)松针精油微囊制备:100g松针精油中加100g 95%乙醇,加入350g环糊精及2000g蒸馏水混合均匀,用胶体磨研磨20min,减压抽滤,用无水乙醇洗涤包合物,于50℃真空干燥箱干燥40h,得450g包合物,即松针精油微囊。
(4)中药足浴泡腾片制备:
①称取10g烷基二苄醚双氯化铵微囊、3g松针精油微囊、3g中药乙醇提取物、20g氨基三乙酸、35g氯化钠、15g硫酸钠、3g硫酸锌,2g硼砂混合均匀;
②颗粒过20目筛,整粒;
③将12g碳酸钠、18g碳酸氢钠、3g滑石粉及8g羧甲基纤维素钠到步骤②的颗粒中,混匀,压片,制得杀菌泡腾片。
应用实施例
在实施例4中不添加季铵盐微囊与精油微囊,分别添加中药乙醇提取物,中药乙醇提取物与氯化钠,其他成分不变,制备泡腾片,与实施例1-4制备的中药足浴泡腾片用于红色毛癣菌、犬小孢子菌、白色念珠菌、絮状表皮癣菌致病真菌,大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌抑菌实验。实验中将中药足浴泡腾片的200倍稀释液对以上菌作用2min,结果如表1。
表1中药足浴泡腾片的抑菌结果
从表1可以看出,本发明制备的含盐中药足浴泡腾片对足癣引起的致病真菌和足部易感染细菌的抑菌率达90%以上,具有较好抑菌效果。不添加季铵盐微囊与精油微囊,仅添加中药乙醇提取物或中药乙醇提取物与氯化钠制备的泡腾片,抑菌效果要差一些。
Claims (10)
1.一种含盐中药足浴泡腾片,由下述重量份的原料制成:氯化钠25~35份,中药乙醇提取物0.5~3份,季铵盐微囊5~10份,精油微囊2~5份,黏结剂5~10份,泡腾剂35~70份,硫酸钠10~15份,硫酸锌1~3份,硼砂0.5~3份和润滑剂1~3份;
其中,所述的中药乙醇提取物为:苦参12~15份、艾叶10~20份、川穹10~15份、鸡血藤8~15份、穿心莲8~12份、白鲜皮5~10份、甘草15~20份、薄荷16~20份和苍术14~16份,混合后的乙醇提取物。
2.根据权利要求1所述的含盐中药足浴泡腾片,其特征在于:所述的季铵盐为十二烷基二甲基苄基溴化铵、双烷基甲基羟乙基溴化铵、2-(2-羟乙基)-甲基-(1-甲基-咪唑-2-亚甲基)氯化铵、或烷基二苄醚双氯化铵中的一种。
3.根据权利要求1所述的含盐中药足浴泡腾片,其特征在于:所述的精油为薰衣草精油、茶树精油、尤加利精油、香茅精油、佛手柑精油、鼠尾草精油或松针精油中的一种。
4.根据权利要求1所述的含盐中药足浴泡腾片,其特征在于:所述的黏结剂选自聚乙烯醇、共聚维酮、聚乙烯吡咯烷酮、或羧甲基纤维素钠中一种。
5.根据权利要求1所述的含盐中药足浴泡腾片,其特征在于:所述的泡腾剂由酸源和二氧化碳源组成,其中,酸源为己二酸、琥珀酸、戊二酸、或氨基三乙酸中一种;酸源用量15~30份;二氧化碳源为碳酸钠、碳酸氢钠、或过碳酸钠中的两种或三种;二氧化碳源用量20~40份。
6.根据权利要求1所述的含盐中药足浴泡腾片,其特征在于:所述的润滑剂选自硬脂酸镁或滑石粉中的一种。
7.制备权利要求1所述含盐中药足浴泡腾片的方法,包括以下步骤:
(1)中药乙醇提取物制备:按重量份称取苦参12~15份、艾叶10~20份、川穹10~15份、鸡血藤8~15份、穿心莲8~12份、白鲜皮5~10份、甘草15~20份、薄荷16~20份和苍术14~16份,加入10~20倍量的75%乙醇浸泡30~40min,加热回流1~2h提取2~3次,合并提取液,浓缩、干燥,粉碎过20目筛,得中药乙醇提取物备用;
(2)季铵盐微囊制备:取季铵盐加等量95%乙醇稀释,并加入环糊精和蒸馏水混合均匀,用胶体磨研磨成糊状物、减压抽滤,用无水乙醇洗涤,沉淀物干燥得季铵盐微囊备用;
(3)精油微囊制备:取精油加等量95%乙醇稀释,并加入环糊精和蒸馏水混合均匀,用胶体磨研磨成糊状物、减压抽滤,用无水乙醇洗涤,沉淀物干燥得精油微囊备用;
(4)泡腾片制备:
称取中药乙醇提取物0.5~3份、季铵盐微囊5~10份、精油微囊2~5份、泡腾剂酸源15~30份、氯化钠25~35份、硫酸钠10~15份、硫酸锌1~3份、硼砂0.5~3份,混合均匀;过20目筛,整粒;再加入泡腾剂二氧化碳源20~40份、黏结剂5~10份及润滑剂1~3份,混匀,干燥、压片,制得所需含盐中药足浴泡腾片。
8.根据权利要求7所述的制备含盐中药足浴泡腾片的方法,其特征在于:步骤(2)中,所述的季铵盐与环糊精的质量比为1:3~6,环糊精为β-环糊精或羟丙β-环糊精中之一种;环糊精与蒸馏水的质量比为1:3~6。
9.根据权利要求7所述的制备含盐中药足浴泡腾片的方法,其特征在于:步骤(3)中,所述的精油与环糊精的质量比为1:3~6,环糊精为β-环糊精或羟丙β-环糊精中之一种;环糊精与蒸馏水的质量比为1:3~6。
10.根据权利要求7所述的制备含盐中药足浴泡腾片的方法,其特征在于:步骤(2)和步骤(3)中,所述的研磨时间为15~25min;各步骤中所述的干燥均采用常规的真空干燥或鼓风干燥。
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