CN107517975A

CN107517975A - A kind of Pesticidal combination

Info

Publication number: CN107517975A
Application number: CN201610451518.6A
Authority: CN
Inventors: 罗昌炎; 詹姆斯·T·布里斯托
Original assignee: Jiangsu Rotam Chemical Co Ltd
Current assignee: Jiangsu Rotam Chemical Co Ltd
Priority date: 2016-06-21
Filing date: 2016-06-21
Publication date: 2017-12-29

Abstract

The invention provides a kind of insecticides, its active component is made up of pyriminostrobin and Ivermectin HCL.Individually active, the of the invention Pesticidal combination compared to each compound, shows obvious synergy.Described Pesticidal combination is used for the purposes for preventing or controlling harmful organism, especially controls the purposes of the insects such as Panonychus citri, Tetranychus cinnabarinus, Tetranychus urticae, pear sucker, aphid, diamondback moth, rice leaf roller, striped rice borer.The present invention also provides a kind of method for protecting useful plant to prevent pest infestation.The present invention also provides a kind of method for protecting seed, seedling root and branch to be attacked to prevent soil and foliar insect.

Description

A kind of Pesticidal combination

Technical field

The present invention relates to pesticide field, and in particular to a kind of Pesticidal combination containing pyriminostrobin and Ivermectin HCL；It is described Pesticidal combination be particularly suitable for prevent and treat animal pest.The invention further relates to protection seed, seedling root and branch to prevent soil With the method for foliar insect invasion and attack.

Background technology

Chemical prevention is agriculturally to prevent and control an important means for insect.However, currently due to the kind of insect etc. Reason, the prevention effects such as effect caused by class, living nature, living environment etc. is poor, repellence prosperity are not always satisfactory.

Ivermectin HCL (Ivermectin) is the antibiotic insecticide developed by Merck companies.Ivermectin HCL by with Chloride channel combines, and prevents the normal operation of chlorion from playing a role.The effect target body of Ivermectin HCL is insect peripheral nerve R- aminobutyric acids (GABA) acceptor in system.It can promote r- aminobutyric acids to be discharged from nerve endings, strengthen r- aminobutyric acids And the combination of acceptor on cell membrane, so that into the chlorion increase of cell, cell membrane hyperpolarization, cause nerve signal transmission It is suppressed, cause paralysis, death.Ivermectin HCL is mainly used in preventing and treating animal parasite at present, agriculturally using less.Therefore, Ivermectin HCL will have broad prospects as pesticide developing.

Pyriminostrobin (Pyriminostrobin), disclosed by CN101906075 known.Pyriminostrobin can be used for preventing and treating a variety of evils Worm, evil mite, especially there is prominent prevention effect to mite class.Its structural formula is as follows：

It is in the urgent demand that field of pest control occurs：Need to provide a kind of Pesticidal combination, it is being reduced The rate of application of active component and reduction avoid remaining to provide effective insect while unfavorable environment or toxicological effects Preventing and treating；And the Pesticidal combination also needs to combine the snap action and long-acting to insect.

It is to repeat using another difficulty of insecticide and uniquely uses single Pesticidal compound in many cases Cause to produce the reactive compound quick selection that is natural or adapting to drug-fast insect.It is therefore desirable to have help overcome Drug-fast Pesticidal combination.

It is therefore an object of the present invention to provide a kind of Pesticidal combination, it solve at least a kind of above-mentioned problem：As reduced Rate of application, improve activity profile, with reference to quick-acting and lasting effect, delaying drug resistance.

The content of the invention

The purpose of the present invention is to solve above-mentioned at least one problem or its at least one aspect, especially for effective control Harmful organism, screened through a large amount of biological tests, the present inventor is it has unexpectedly been discovered that can use pyriminostrobin and Ivermectin HCL combination In effective prevention or control harmful organism.It is surprising that the work of the combination control harmful organism of reactive compound of the present invention Property is much higher than single active ingredient physical performance summation.The unexpected effect is real cooperative effect, and not only It is supplementary function.

Therefore, it is an object of the present invention to provide a kind of Pesticidal combination, its active component is by pyriminostrobin and Yi Wei bacterium Element composition.

A kind of Pesticidal combination, its active component are made up of pyriminostrobin and Ivermectin HCL, the pyriminostrobin and Ivermectin HCL Weight proportion be 1:1-200:1, preferably 1:1-150:1, more preferably 1:1-100:1, preferably 1:1-90:1, more preferably 1:1- 80:1, more preferably 1:1-70:1, more preferably 1:1-65:1, more preferably 1:1-60:1, more preferably 1:1-55:1, more preferably 1:1- 50:1, more preferably 2:1-50:1, more preferably 3:1-50:1, more preferably 4:1-50:1, more preferably 5:1-50:1, more preferably 6:1- 50:1, more preferably 7:1-49:1, more preferably 8:1-48:1, more preferably 9:1-47:1, more preferably 10:1-46:1, more preferably 10:1- 45:1, more preferably 10:1-44:1, more preferably 10:1-43:1, more preferably 10:1-42:1, more preferably 10:1-41:1, more preferably 10:1-40:1。

A kind of Pesticidal combination, active component are made up of pyriminostrobin and Ivermectin HCL, the pyriminostrobin and Ivermectin HCL Total amount accounts for the 1%-90% of the composition by weight.

A kind of Pesticidal combination, active component are made up of pyriminostrobin and Ivermectin HCL, the pyriminostrobin and Ivermectin HCL Total amount accounts for the 5%-80% of the composition by weight.

A kind of Pesticidal combination, active component are made up of pyriminostrobin and Ivermectin HCL, the pyriminostrobin and Ivermectin HCL Total amount accounts for the 5%-70% of the composition by weight.

A kind of Pesticidal combination, active component are made up of pyriminostrobin and Ivermectin HCL, the pyriminostrobin and Ivermectin HCL Total amount accounts for the 5%-60% of the composition by weight.

A kind of Pesticidal combination, active component are made up of pyriminostrobin and Ivermectin HCL, the pyriminostrobin and Ivermectin HCL Total amount accounts for the 5%-55% of the composition by weight.

A kind of Pesticidal combination, active component are made up of pyriminostrobin and Ivermectin HCL, the pyriminostrobin and Ivermectin HCL Total amount accounts for the 10%-50% of the composition by weight.

A kind of Pesticidal combination, active component are made up of pyriminostrobin and Ivermectin HCL, the pyriminostrobin and Ivermectin HCL Total amount accounts for the 10%-40% of the composition by weight.

A kind of Pesticidal combination, active component are made up of pyriminostrobin and Ivermectin HCL, the pyriminostrobin and Ivermectin HCL Total amount accounts for the 10%-30% of the composition by weight.

A kind of Pesticidal combination of the present invention, also comprising surfactant and/or filler.

The Pesticidal combination of the present invention, formulation are missible oil, suspending agent, seed treatment dry powder doses, seed treatment suspending agent, water It is dispersible granule, wettable powder, suspension emulsion, smoke agent, coated granule, extrusion granule, aqueous emulsion, microcapsule suspending agent, micro- Capsule suspension-suspending agent, dry suspending agent, ultra low volume liquids.

On the other hand, it is used to prevent present invention also offers a kind of Pesticidal combination by the present invention or controls harmful organism Purposes, wherein harmful organism be selected from Insecta (Insecta), Arachnoidea (Arachnida), Nematoda (Nematoda).

The harmful organism of the present invention may be selected from Lepidoptera, Diptera, coleoptera, Semiptera, Homoptera, Orthoptera, film wing Mesh, Isoptera, Siphonaptera, Blattaria, Thysanoptera, Acarina, nematode etc..

Preferably, Pesticidal combination of the invention is used to prevent and treat Panonychus citri, Tetranychus cinnabarinus, Tetranychus urticae, pear sucker, aphid Worm, diamondback moth, rice leaf roller, striped rice borer.

On the other hand, present invention also offers a kind of method prevented or control harmful organism, by the desinsection group of the present invention Compound acts on target useful plant or its environment, object noxious livings or its environment, the propagating materials of target useful plant.Institute It is seedling, rhizome, garden seedling, cutting or seed to state plant propagation material.

A kind of method for protecting useful plant to prevent pest infestation, including make the Pesticidal combination and target of the present invention The propagating materials contact of useful plant or its environment, object noxious livings or its environment, target useful plant.

The present invention provides a kind of protection useful plant to prevent the method for pest infestation, and it is included in target useful plant Or its environment, object noxious livings or its environment, target useful plant propagating materials on wished sequentially or simultaneously with any Using the pyriminostrobin and Ivermectin HCL in the Pesticidal combination of the present invention.

The present invention provides one kind in plant propagation material and in growing plants organ, plant part and/or plant afterwards The method of middle preventing and treating or prevention harmful organism, plant propagation material or its environment are applied to by Pesticidal combination of the present invention On.

The present invention also provides a kind of method prevented or control harmful organism, by the activity in the Pesticidal combination of the present invention Composition pyriminostrobin and Ivermectin HCL separately or cooperatively act on seed.

Pyriminostrobin and Ivermectin HCL in the Pesticidal combination of the present invention are present in one on seed layer or different layers.

The present invention also provides a kind of method for protecting useful plant to prevent pest infestation, by desinsection of the present invention Active component pyriminostrobin and Ivermectin HCL in composition separately or cooperatively act on seed.

On the other hand, the Pesticidal combination for being related to the present invention is used to handle seed or the use for handling genetically modified plants On the way, or more specifically, for the purposes for the seed for handling genetically modified plants.

The present invention also provides a kind of method for protecting seed, seedling root and branch to be attacked to prevent soil and foliar insect, bag Including contacts seed and the described Pesticidal combination of the present invention before sowing and/or after vernalization.

Compared with prior art, the present invention at least has the advantages that：

(1) after the present invention compounds both pyriminostrobin and Ivermectin HCL, compared with single dose, synergy is obvious, improves Insecticidal effect；

(2) after the present invention compounds both pyriminostrobin and Ivermectin HCL, both mechanisms of action and the mode of action are entirely different, There is good killing action after combination to low age and high instar larvae, action site increase, be advantageous to overcome and delay insect Drug-fast generation；

(3) after the present invention compounds both pyriminostrobin and Ivermectin HCL, times for spraying is reduced, reduces drug cost, is reduced Environmental pollution and residues of pesticides；In addition, it adds somewhat to the preventing and treating spectrum of insect；

(4) Pesticidal combination of the invention has to pear sucker, Panonychus citri, Tetranychus urticae, Tetranychus cinnabarinus, aphid, diamondback moth Special preventive effect.

Embodiment

Unless otherwise defined, ratio of the present invention is weight proportion, and content of the present invention is weight Content.

Present invention discover that：The insecticidal activity of the Pesticidal combination of the present invention is much higher than the active of independent reactive compound Summation.There is unpredictalbe real cooperative effect, rather than just activity plus and.

The insecticidal effect that term " synergy " used herein refers to the Pesticidal combination of the present invention is more than each activation Compound effect sum, in other words, its effect is superadditivity.

In the presence of active component is with specific weight proportion in the Pesticidal combination of the present invention, synergy is particularly significant. The weight proportion of active component can change in relatively wide scope.

The present invention provides a kind of Pesticidal combination, and its active component is made up of pyriminostrobin and Ivermectin HCL, the pyriminostrobin Weight proportion with Ivermectin HCL is 1:1-200:1, preferably 1:1-150:1, more preferably 1:1-100:1, preferably 1:1-90:1, more It is preferred that 1:1-80:1, more preferably 1:1-70:1, more preferably 1:1-65:1, more preferably 1:1-60:1, more preferably 1:1-55:1, it is more excellent Select 1:1-50:1, more preferably 2:1-50:1, more preferably 3:1-50:1, more preferably 4:1-50:1, more preferably 5:1-50:1, more preferably 6:1-50:1, more preferably 7:1-49:1, more preferably 8:1-48:1, more preferably 9:1-47:1, more preferably 10:1-46:1, more preferably 10:1-45:1, more preferably 10:1-44:1, more preferably 10:1-43:1, more preferably 10:1-42:1, more preferably 10:1-41:1, more It is preferred that 10:1-40:1.

The weight proportion of the pyriminostrobin and Ivermectin HCL can also be：1:1、2:1、3:1、4:1、5:1、6:1、7:1、8: 1、9:1、10:1、11:1、12:1、13:1、14:1、15:1、16:1、17:1、18:1,19:1,20:1,21:1、22:1,23:1、 24:1,25:1、26:1,27:1、28:1,29:1、30:1、31:1、32:1、33:1、34:1、35:1、36:1、37:1、38:1、 39:1、40:1、41:1、42:1、43:1、44:1、45:1、46:1、47:1、48:1、49:1、50:1、51:1、52:1、53:1、 54:1、55:1、60:1,65:1、70:1、75:1、80:1、85:1、90:1、95:1、100:1,110:1、120:1、130:1、 140:1、150:1、160:1、170:1、180:1,190:1 or 200:Specific point value between 1, and above-mentioned numerical value, is limited to a piece Width and the consideration for simplicity, the present invention specific point value that no longer scope described in exclusive list includes.

The total amount of active compound component can be selected according to material elements in the Pesticidal combination of the present invention, with reality Existing desired effect.The factor is for example, formulation, object to be administered, application process etc..Pyriminostrobin and Ivermectin HCL account for altogether The composition 5%-90% by weight, more preferably preferably 10%-80%, more preferably 10%-70%, 10%-60%, more It is preferred that 10%-50%, more preferably 10%-40%, more preferably 10%-30%.

The pyriminostrobin and Ivermectin HCL account for altogether the Pesticidal combination can also be 1%, 5%, 8%, 10%, 12%th, 15%, 18%, 20%, 21%, 21.5%, 22%, 22.5%, 23%, 23.5%, 24%, 24.5%, 25%, 28%th, 30%, 32%, 35%, 38%, 40%, 42%, 45%, 48%, 50%, 52%, 55%, 58%, 60%, 62%, 65%th, the tool between 68%, 70%, 72%, 75%, 78%, 80%, 82%, 85%, 88% or 90%, and above-mentioned numerical value Body point value, as space is limited and for concise consideration, the present invention specific point value that no longer scope described in exclusive list includes.

The composition of the present invention optionally includes agronomically acceptable surfactant and/or filler.

According to the present invention, term " filler ", which refers to, can be combined with reactive compound or combines to make it easier for being administered to The natural or synthetic organic or inorganic compound of object (such as plant, crop or careless class).Therefore, the carrier is preferably lazy Property, at least it should be agronomically acceptable.The filler can be solid or liquid.

The inactive filler that can be used in the present invention can be solid or be liquid, can be used as solid What filler used has for example：Phyteral powdery type (such as soy meal, starch, grain dust, wood powder, bark powder, sawdust, walnut Shell powder, wheat bran, cellulose powder, coconut husk, the particle of corncob and tobacco stem, extract residue after plant essence etc.), paper Open, sawdust, crush synthesized polymer body, clay class (such as kaolin, bentonite, acid china clay etc.), the talcum powder of synthetic resin etc. Class.Silica (such as diatomite, silica sand, mica, aqueous silicic acid, calcium silicates), activated carbon, natural mineral matter class (float stone, Lv Po Thread stone and zeolite etc.), fire diatomite, sand, (such as polyethylene, polypropylene, polyvinylidene chloride etc.), the chlorination such as plastics medium Chemical fertilizer, the soil of the inorganic mineral powder of potassium, calcium carbonate, calcium phosphate etc., ammonium sulfate, ammonium phosphate, urea, ammonium chloride etc. Fertilizer, these materials can be used alone or two or more is mixed.

What can be used as liquid filler can select in llowing group of materials, such as water, alcohol type (such as methanol, Ethanol, isopropanol, butanol, ethylene glycol etc.), ketone (such as acetone, methyl ethyl ketone, isobutyrone, cyclohexanone etc.), ether Class (such as ether, dioxanes, methylcellulose, tetrahydrofuran etc.), aliphatic hydrocarbon class (such as kerosene, mineral oil Deng), aromatic hydrocarbons class (such as benzene,toluene,xylene, solvent naphtha, alkylnaphthalene, chlorinated aromatic hydrocarbons, chlorinated aliphatic hydrocarbon, Chlorobenzene, etc.), halogenated hydrocarbon class, amide-type, sulfone class, dimethyl sulfoxide (DMSO), mineral and vegetable oil, animal oil etc..

To make the emulsification of active ingredient compound, scattered, solubilized and/or wetting to use surfactant example AEO, polyoxyethylene alkylaryl ether, polyoxyethylene higher fatty acid esters, polyoxyethylene alcohol can such as be enumerated Or the branch shape copolymerization of the phosphate of phenol, the fatty acid ester of polyalcohol, naphthalene sulfonic acid polymer, lignosulfonates, macromolecule comb shape Thing, butyl naphthalene sulfonate, alkylaryl sulfonates, sodium alkylsulfosuccinates, grease, fatty alcohol and ethylene oxide condensate, Polyacrylate, the protein hydrolysate of alkyltaurate.Suitable oligosaccharide thing or polymer, such as based on single second Alkene monomer, acrylic acid, polyoxyethylene and/or polyoxypropylene or itself and such as combination of (polynary) alcohol or (polynary) amine.

To make scattered active ingredient compound, stabilisation, attachment, such as xanthans, aluminium-magnesium silicate, gelatin, shallow lake can be used Powder, methyl cellulose, polyvinyl alcohol, polyvinyl acetate and natural phospholipid (such as cephalin and lecithin) and synthetic phospholipid, The adjuvants such as bentonite, sodium lignin sulfonate.

The wherein optional spent glycol of antifreezing agent, propane diols, glycerine, sorbierite.Deflocculant as suspension product The adjuvant such as naphthalene sulfonic acid polymer, polymeric phosphate can be used.Organic silicon defoamer can be used as defoamer.For The mobility of solid product is improved, the adjuvant such as paraffin, stearate, alkylphosphonate can be used.

The colouring agent that can be used, such as inorganic pigment, such as iron oxide, titanium oxide and Prussian blue；And organic pigment/ Dyestuff：Alizarin dyes, azo dyes and metallized phthalocyanine dye；And trace element, such as molysite, manganese salt, boron salt, mantoquita, cobalt Salt, molybdenum salt and zinc salt.

Optionally, can also include other annexing ingredients, for example, protecting colloid, adhesive, thickener, thixotropic agent, bleeding agent, Stabilizer, screening agent.

The formulation of Pesticidal combination of the present invention is：Aerosol, suspending agent, microcapsulated granule, granula subtilis, flowable concentrate, Ready to use solution agent, pulvis, aqueous emulsion, oil emu, fine granule, oil dispersed pulvis, the miscible mobility concentrate of oil, oily miscible fluid Body, foaming agent, paste, suspending concentrate, suspension emulsion, solubility concentrate, soluble powder, granule, water-soluble granular and/ Or in tablet, water solube powder, wettable powder, the natural or synthetic material impregnated through reactive compound, polymeric material Microcapsules and water-dispersible granule.

In preferred embodiments, the Pesticidal combination is missible oil, at suspending agent, seed treatment dry powder doses, seed Manage suspending agent, water dispersible granules, wettable powder, suspension emulsion, smoke agent, coated granule, extrusion granule, aqueous emulsion, micro- Capsule suspending agent, microcapsule suspension-suspendinagent agent, dry suspending agent, ultra low volume liquids.

The preparation of the present invention can be mixed the reactive compound to prepare by known way with conventional additives. For example conventional extender of the conventional additives and solvent or diluent, emulsifying agent, dispersant, and/or adhesive or fixative, Wetting agent, waterproofing agent, if it is desired, drier and colouring agent, stabilizer, pigment, defoamer, preservative, increasing can also be included Thick dose, water and other processing aids.

These compositions not only include can be by suitable equipment as sprayed or dusting equipment is immediately suitable for pending Object, and be additionally included in and be applied to the concentration commercial composition that object needs to be diluted before.

The Pesticidal combination of the present invention can be made in the form of the composition of its active compound component suitable for administration Preparation, it can also be applied in the form of the combination of the commercial preparation of its suitable dosage.

The Pesticidal combination of the present invention can also be applied with other active ingredient combinations, and other active components for example kill Epiphyte pharmaceutical, bactericide, attractant, insecticide, acaricide, nematicide, growth regulator, herbicide, safener, fertilizer Or semiochemical etc..

The Pesticidal combination of the present invention, with thering is good plant compatibility and favourable homeothermal animal toxicity to be combined, fit Share in：Protect plant and plant organ；Improve harvesting yield；Improve the quality of harvesting material；And for prevent and treat agricultural, Insect, arachnid, worm, the nematode and soft run into gardening, forestry, protection Stored Product and material and health field Body animal.The Pesticidal combination of the present invention is preferably used as plant protection product.The Pesticidal combination of the present invention to generally sensitive and The species of resistance are active, and are respectively provided with activity for all or single stage of development.And also realize prevention or control Harmful organism is amazing " synergy ".

" harmful organism " of the present invention includes harmful Insecta (Insecta), Arachnoidea (Arachnida), Nematoda (Nematoda)。

Insecta includes Lepidoptera, coleoptera, Diptera, Semiptera, Homoptera, Hymenoptera, Thysanoptera, Isopoda, times Sufficient mesh, lip foot mesh, comprehensive mesh, Thysanoptera, Collembola, Collembola, Orthoptera, Blattaria, Dermaptera, Isoptera, Anoplura.

Lepidoptera pest, such as：Striped rice borer (chilosuppressalis (walker), yellow rice borer (Tryporyzaincertulas (walker)), rice leaf roller (cnaphalocrocismedinalisGuenee), cabbage heart It is snout moth's larva (hellullaundalis), dichocrocis punctiferalis (conogethespunctiferlis), papilio xuthus Linnaeus (papilioxuthus), white White butterfly (pierisrapaecrucivora), straight burr rice hesperiidae (parnaraguttata), tent caterpillar (malacosoma Neustria testacea), gypsymoth (lymantriadispar), fall webworms (hyphantriacunea), east poison moth (euproctissubflava), black line slug moth (scopelodescontracus), bollworm (helicoverpaarmigera), Pectinophora gossypiella (Pink bollworm), cabbage looper (trichoplusiani), wild cabbage night Moth (mamestrabrassicae), beet armyworm (spodopteraexigua), prodenia litura (spodopteralitura), Tea olethreutid (adoxophyesoranafasciata), leaf roller (adoxophyeshonmai), apricot yellow volume moth (archipsfuscocureanus), Homonamagnanima (homonamagnanima), diamondback moth (plutellaxylotella), cotton Pink bollworm (pectinophoragossypiella).

Coleopteran pest, such as：Rice weevil (sitophilusoryzaelinne), citrus leaf mining first (Podagricomela Nigricollis Che), sitophilus zea-mais (S.zeamails), grain weevil (S.granarius), big daikon leaf beetle (Cabbageleafbeetle), daicon leaf beetle (Daikon leaf beele), flea beetle (fleabeetle), grape flea beetle (Alticachalybea), cabbage flea beetle (phyllotretastriolata), cucumber flea beetle (Epitrixcucumeris), cigarette Careless flea beetle (Ehirtipennis), eggplant flea beetle (E.fuscula), aulacophora femoralis (Aulacophoraindica (Gemlin), leaf mustard Chrysomelid (Phaedon cochleariae) etc..

Diptera pest, such as：It is rice leafminer (agromyzaoryzae), hydrellia griseola (hydrelliagriseola), non- The latent fly (chromatomyiahorticola) of continent chrysanthemum liriomyza bryoniae (liriomyzatrifolii), pea leaf, Liriomyza brponiae (liriomyzabryoniae), delia platura (deliaplatura), green onion ground Hylemyia Platura Meigen (deliaantiqua) Mediterranean fruitfly (ceratitiscapiatawiedgman), Rhagoletis pomonella (Rhagoletispomonella), cherry fruit fly (R.cingulata)。

Hemipteran pest, such as：Smelly stinkbug (megacoptapunctatissimum), cabbage bug (eurydemarugosum), Big thorn white star stinkbug (eysarcorislewisi), white star stinkbug (eysarcorisparvus), green rice bug (nezaraviridula), Si Shi ambers stinkbug (plautiastali), clerodendron trichotomum stinkbug (halymorphamista), rice spiny coreid (cletuspunctiger), in Magnificent Leptocorisa spp (leptocorisachinensis), azelea lace bug (stephantispyrioides), red palpus fleahopper (trigonotyluscoelestialium)。

Homoptera pest, such as rice green leafhopper (nephotettixcincticeps), small brown rice planthopper (laodelphaxstriatellus), brown plant-hopper (nilaparvatalugens), white backed planthopper (sogatellafurcifera), pear sucker (psyllapyrisuga), diaphorina citri (diaphorinatabaci), Bemisia tabaci (bemisiatabaci), aphid (homoptera), apple aphid (eriosomalanigerum).

Hymenoptera (hymenoptera) insect, such as yellow-winged cabbage sawfly (athaliarosaeruficornis), japanese rose leaf Honeybee (argepagana), Black Hills ant (formica japonica), chestnut gall wasp (dryocsmuskuriphilus) etc..

Thysanoptera, for example, thrips (HaplothripsChinensisPriesner).

Isopoda (Isopoda), for example, Cape jasmine beach louse (Oniscus asellus), pillworm (Armadilliudium Vulgare), ball pillworm (Porcellio scaber).

Sufficient mesh insect again, for example, Blaniulus guttulatus.

Lip foot mesh insect, for example, ground Scolopendra (Geophilus carpophagusScutigera spp.).

Comprehensive mesh insect, for example, kahikatea worm (Scutigerella immaculata).

Thysanoptera insect, for example, silverfish (Lepisma saccharina).

Collembola insect, for example, arms Onychiurus arcticus (Onychiurus armatus).

Orthoptera pest, for example, family Xi (Acheta domesticus), mqb category category kind of (a Gryllotalpa spp.), Asiatic migratory locust (Locusta migratoriamigrator ioides), black locust category kind (Melanopluss pp.), desert locust (Schistocercagregaria)。

Blattaria insect, for example, oriental cockroach (Blattaorientalis), American cockroach (Periplaneta Americana), leucophaea maderae (Leucophaea maderae), Groton bug (Blattella germanica).

Dermaptera insect, for example, European earwig (Forficula auricularia).

Isoptera insect, for example, Reticulitermes kind (Reticulitermes spp.).

Anoplura (Anoplura, Phthiraptera), such as Damalinia (Damalinia spp.), Haematopinus (Haematopinus spp.), Linognathus (Linognathus spp.), Pediculus (Pediculus spp.), Trichodectes (Trichodectes spp.)。

The insect of Arachnoidea (Arachnida), such as panonychus citri (panonychus citri), Tetranychus cinnabarinus (Tetranychus cinnabarinus), panonychus ulmi (panonychus ulmi), Tetranychus urticae (tetranychus Urticae), tetranychus viennensis (tetranychus viennensis), oligonychus ununguis (oligonychus ununguis), mandarin orange Tangerine beginning tetranychid (eotetranychus kankitus), purplish red short hairs mite (brevipalpus phoenicis), Bryobia praetiosa (bryobiapraetiosa), wheat leaf roll mite (aceria tulipae), grape erineum mite (Eriophyes vitis) (colomerus vitis), tealeaves Goitre mite (calacarus carinatus), yellow tea mite (polyphagotarsonemus latus), long hair root mite (rhizoglyphus rostochiensis), Acarus siro (Acarus siro), citrus aceria (Aceria Sheldoni), steinman pin thorn goitre mite (Aculus schlechtendali), Tetranychus (Tetranychus spp.), Panonychus citri Belong to (Panonychus spp.), wrinkle Genus Phyllocoptess (Phyllocoptruta spp.), short whisker Acarapis (Brevipalpus Spp.) etc..

The representative biology of Nematoda ((Nematoda)) has selected from Meloidogyne (Meloidogyne spp.), different skin Turbatrix (Heterodera spp.), ball Heterodera (Globodera spp.), perforation line Eimeria (Radopholus Spp.), Pratylenchus (Pratylenchus spp.), minute hand Turbatrix (Longidorus spp.) etc..It is preferred that lower alignment Soybean cyst nematode Heterodera glycines (Heterodera), globodera rostochiensis (golbodera rostochiensis), the Root Knot line of worm Worm (meloidogyne incognita) etc..

The Pesticidal combination of the present invention is for resisting insect, such as insect, immature insect, insect at initial stage and insect ovum It is environment effective and that insect or their existence can be applied directly to.The insect controlled according to the Insecticidal combinations of the present invention Insect pest, storage insect insect, clothes insect and furniture insect including agricultural/horticultural insect, health.

The Pesticidal combination of the present invention can not only bring the additive property raising for insecticidal spectrum, but also realize prevention or control Harmful organism processed is amazing " synergy ".

On the other hand, present invention also offers a kind of method prevented or control harmful organism, by the desinsection group of the present invention Compound is applied to target useful plant or its environment, object noxious livings, the propagating materials of target useful plant.

The Pesticidal combination of the present invention shows particularly advantageous effect when being applied to such as following useful plant.Herein The implication of plant is interpreted as all plants and plant population, if desired for unwanted wild plant or crop plants (including Naturally occurring crop plants).Crop plants are that by conventional breeding and method for optimizing or can pass through biotechnology and heredity Engineering method or the plant that can be obtained by the combination of these methods, the plant include genetically modified plants, also include being planted Thing breeder weighs (plant breeders'rights) protection or the plant variety not being protected by it.The implication of plant parts should Be interpreted as plant part all above and below the ground and organ, such as branch, leaf, Hua Hegen, the example that can be mentioned that be leaf, Pin, leaf, stem, dry, flower, fructification, fruit and seed, Yi Jigen, stem tuber and rhizome.The plant parts also include harvested material with And it is asexual with generative propagation thing, such as transplant, stem tuber, rhizome, sprout and seed.

The suitable plant of the Pesticidal combination of the present invention includes：

Crops：Corn, rice, wheat, barley, rye, oat, sorghum, cotton, soybean, red bean, Kidney bean, peanut, buckwheat Wheat, beet, rape, sunflower, sugarcane, tobacco etc.；

Vegetables：Solanum vegetables (eggplant, tomato, red green pepper, Chinese prickly ash, potato etc.), cucurbitaceae vegetable (cucumber, Pumpkin, cucurbita pepo, watermelon, wax gourd, pumpkin etc.), brassicaceous vegetable (japanese radish, ternip, horseradish, root-mustard, Chinese cabbage, Wild cabbage, leaf mustard, broccoli, cauliflower etc.), Aster section vegetables (burdock, garland chrysanthemum, jerusalem artichoke, romaine lettuce etc.), liliaceous vegetable (shallot, Onion, garlic, and asparagus), carrot, caraway, celery, Indian Epimeredi Herb, goosefoot vegetable (spinach, Swiss chard etc.), Peppermint section vegetables (Perilla frutescens, peppermint, sweet basil etc.), strawberry, sweet potato, dioscorea japonica and glycan etc.；

Flowers：Rose, China pink, chrysanthemum, tulip, rough gentian, orchid etc.；

Foliage plant；

Turfgrass；

Fruit tree：Pomaceous fruits fruit (apple, European pear, Japanese pear, pawpaw, Wen Quinces etc.), stone fruit (peach, plum, oil Peach, Japanese Lee, cherry, apricot, plum etc.), citrus fruit (satsuma orange, orange, lemon, coming lemon, grape fruit etc.), nut fruits (chestnut, English walnut, fibert, almond, American pistachios, cashew nut, macadamia etc.), berries (blueberry, the red certain kind of berries, blackberry, blueberry, mountain are mould etc.), Portugal Grape, persimmon, olive, plum, banana, coffee, nipa palm and coconut etc.；

Trees beyond fruit tree：Tea tree, mulberry tree, flowering tree, shade tree (Chinese scholartree, birch, Fructus Corni, eucalyptus, ginkgo Tree, lilac, maple, robur, willow, cercis, sweetgum, plane tree, Chinese juniper tree, pine tree, dragon spruce and taxus chinensis in northeast) etc..

It is emphasized that the Pesticidal combination of the present invention is used for effect particularly advantageous during such as following plant：Cereal Such as wheat, oat, barley, spelt (spelt), triticale and rye, and corn, jowar He Li, rice, sugarcane, It is soybean, sunflower, potato, cotton, rape (oil seed rape), canola (canola), tobacco, beet, feeding Beet, asparagus, hops and fruit bearing plant (including the operatic circle such as apple and pears, drupe such as peach, honey peach, cherry, plum, apricot, citrus Class fruit such as orange, grape cypress, bitter orange, stubborn Lu, cumquat, citrus and Sa Mo tangerines, nut such as almond, walnut and America mountain core Peach, tropical fruit (tree) such as mango, papaya, pineapple, nipa palm and banana, and grape) and vegetables (including leaf vegetables for example hare's-lettuce, corn salad, Fennel, Leaf lettuce, celery lettuce, Swiss chard, spinach and salad witloof, wild cabbage such as cauliflower, broccoli, romaine lettuce Leaf, savoy, collard, kohlrabi, brussels sprout, red cabbage, white cabbage and savoy, fruit vegetables such as eggplant Son, cucumber, capsicum, edible squash, tomato, bush pumpkin and corn, root vegetables such as celeriac, rape, carrot include Huang Chromaticity kind, wild radish class, beet, celery, legume such as pea and soybean, and allium vegetables such as leek and onion.

The suitable useful plant of the present invention also includes the genetically modified plants converted by recombinant DNA technology.

It is particularly suitable for preventing according to the Pesticidal combination of the present invention or controls the pest and disease damage of following crop：

The Pesticidal combination of the present invention is particularly suitable for citrus, apple, pears, vegetables, a kind of fruit, such as apple, pear, etc., drupe, the prevention of tree nut or control Panonychus citri category (Panonychus spp.) processed.

The Pesticidal combination of the present invention is particularly suitable for citrus, coffee, the prevention of apple fruits and vegetables or control short whisker Acarapis (Brevipalpus spp.)。

The Pesticidal combination of the present invention is particularly suitable for citrus prevention or control wrinkle Genus Phyllocoptess (Phyllocoptruta spp.)。

The Pesticidal combination of the present invention is particularly suitable for citrus, apple fruits and vegetables, a kind of fruit, such as apple, pear, etc., drupe, the prevention of tree nut or control leaf Mite category (Tetranychus spp.).

The Pesticidal combination of the present invention is particularly suitable for citrus, the prevention of apple fruits and vegetables or control homoptera pest (Homoptera)。

The Pesticidal combination of the present invention is particularly suitable for citrus, the prevention of apple fruits and vegetables or control Lepidoptera (Lepidoptera)。

It is further preferred that the Pesticidal combination of the present invention is suitable for citrus, apple, pears, vegetables, a kind of fruit, such as apple, pear, etc., drupe, tree heavily fortified point The preventing and treating such as fruit Panonychus citri, Tetranychus cinnabarinus, Tetranychus urticae, pear sucker, aphid, diamondback moth, rice leaf roller, striped rice borer.

The present invention provides a kind of protection useful plant to prevent the method for pest infestation, and it is included in target useful plant Or its environment, object noxious livings or its environment, target useful plant propagating materials on wished sequentially or simultaneously with any Using the combination for including pyriminostrobin and Ivermectin HCL.

According to processing of the Pesticidal combination of the present invention to plant and plant parts, directly carried out by conventional treatment method Or handle its environment, habitat or storage area to carry out, the conventional treatment method for example immersion liquid, spraying, evaporation, atomizing, Broadcast sowing, smear, and one or more layers can be also coated for propagating materials especially seed.

Plant site is soaked with fluid composition or the effective of solid form is handled into mesh into the method for the present invention Useful organisms, or the compositions-treated object noxious livings with the present invention are marked, can directly be carried out by usual processing method, Or carried out by acting on its environment, habitat or storage areas, the generally processing method is such as by pouring (dipping), drop Fill, spray, evaporating, being atomized, broadcasting sowing, dusting, foaming, the mode such as coating apply (foliage applying) to the blade of plant, can adjust The frequency and dosage applied are saved, is adapted it to by the degree of the harmful organism infestation.

Active ingredient incorporation plant site, such as mix in the form of granules in soil (soil application), effectively into Divide also can enter inside plants (systemic action) by root system.The described plant when the application method of the present invention is implemented Soil or cultivation medium be the supporter for referring to make crops take root, grow, such as：Soil, water etc., specific raw material It can use such as sand, float stone, vermiculite, diatomite, agar-agar, gelling material, polymer substance, asbestos, wood chip, bark.

The method of medicament is applied into soil, such as liquid preparation is diluted in water or do not diluted and is directly applied to plant The methods of in the root of body or the rice seedling bed of seedling；Side granule being disseminated in the root of plant or the rice seedling bed of seedling Method has the method that pulvis, water dispersible granules etc. are sprayed in soil prior to seeding and integrally mixed with soil, before sowing or plants It will be sprayed on before kind plant after pulvis, water-dispersible grain dilution agent in implantation hole, seed furrow, then method sowed etc..

Propagating materials such as seed, fruit, stem tuber or core of the Pesticidal combination of the present invention particularly suitable for protecting plant Benevolence or plant cutting are not encroached on by harmful organism particularly insect and acarid.Can be before administration with the compositions-treated breeding Material, such as dress seed prior to seeding.Also by soaking kernel in fluid composition or kernel can be coated with solid composite, will Active component is applied in benevolence (coating).When propagating materials is applied into for example seed is broadcast in ditch in seeding process, Said composition can be applied to application site.These processing methods to plant propagation material and the plant propagation material being processed as Material is all further subject matter of the present invention.

Term " plant propagation material " is interpreted as referring to all plant parts for having fertility, such as seed, and it can be used In breeding the latter, and vegetable matter such as cuttage bar or stem tuber (such as potato).Therefore, plant used herein Part includes plant propagation material.It is mentioned that such as seed, root, fruit, stem tuber, bulb, rhizome and plant part.Treat The germination plant and effective plant suppressed after being germinateed from soil or after emergence.Young plant can be before transplantation by being impregnated into Row whole or Local treatment are protected.Plant propagation material preferred seed.

The method of the present invention can be applied to the seed of any physiological status.Preferred seed is in state durable enough, So as to without damage in processing procedure.Usually, seed can be harvested from field, remove from plant, be isolated from any fringe Axle, stem, crust and the pulp of surrounding or the seed of other non-seed vegetable materials.Seed can also be stable preferably on biology , to reach the degree that processing will not cause biological damage to seed.It can harvest between seed sowing or broadcast at seed Any time processing during kind process is applied to seed.Seed can also vernalization before and after treatments.

The seed that Pesticidal combination by the present invention is handled can be stored, manage, sowing and farming.

Seed treatment can be by wishing sequentially or simultaneously to apply pyriminostrobin and Ivermectin HCL to it with any.

Seed treatment occurs on unseeded seed, term " unseeded seed " be intended to include in seed harvest and The seed in any period between seed is in plant germination and grows purpose sowing in soil.Preferably, handle and broadcast in seed Occur before kind, so as to which the sowing seed is pretreated with the combination.Especially, seed pelleting or pellet seeds are at this It is preferable to invent in the processing of combination.After processing, the composition in each combination is attached on seed and therefore available for insect pest Preventing and treating.

The present invention also provides a kind of protection seed to prevent soil insect and protection seedling root and branch to prevent soil and blade face The method of insect, it is included in before sowing and/or makes the Insecticidal combinations of the invention of seed and insecticidal effective dose after vernalization Thing contacts.

Therefore, a kind of method for protecting seed, seedling root and branch to be attacked to prevent soil and foliar insect, is included in sowing Contact seed and the Pesticidal combination of effective dose of the present invention in the past and/or after vernalization.

Most of infringement as caused by insect to crop plants is early in seed, and during storage and seed is sown into soil After earth and during plant germination or after germination, when being invaded and harassed just there occurs.This stage is particularly critical, because just in growing plant Root and seedling it is especially sensitive, even small infringement may also lead to the death of whole plant.Therefore, by using suitable group Compound come protect seed and germination plant be of specific interest.

It is known for a long time come pest control and is the theme updated by handles vegetable seeds.However, It is not that can find to solve the problems, such as in a satisfactory manner that processing seed, which is also brought a series of,.Therefore, it is necessary to develop guarantor The method for protecting seed and the plant that germinates, it can exempt after planting or additionally apply crop protection products again after plant germination.Separately Outside, it is also necessary to the amount of reactive compound used in optimization, so as to provide best protection to seed and germination plant, to prevent insect Invasion and attack, and active component used will not damage plant in itself.Especially, the method for handling seed also contemplates for genetically modified plants Intrinsic insecticidal property with the crop protection products of minimum reach to seed and germination plant best protection.

Therefore, the present invention relates particularly to one kind and protects seed and hair by using Pesticidal combination of the present invention processing seed Method of the bud plant from pest attacks.Present invention protection seed and the plant that germinates include using simultaneously from the method for pest attacks The method that pyriminostrobin and Ivermectin HCL handle the seed.It also includes one kind pyriminostrobin and Ivermectin HCL at different time The method for managing the seed.The invention further relates to the present invention Pesticidal combination be used for handle seed with protect the seed and by Purposes of its plant grown from pest attacks.Moreover, it relates to through the present invention Pesticidal combination processing so as to Obtain the seed for being protected from pest attacks.The invention further relates to the seed that pyriminostrobin and Ivermectin HCL are handled simultaneously.The present invention Further relate to the seed handled through pyriminostrobin and Ivermectin HCL in different time.For through pyriminostrobin and Ivermectin HCL in different time The seed of processing, each active component of Pesticidal combination of the present invention can exist in the different layers on the seed.Wherein, contain There is the layer of pyriminostrobin and Ivermectin HCL optionally can be separated by an intermediate layer.The invention further relates to wherein by pyriminostrobin and Yi Wei The seed that rhzomorph is applied as coating ingredients or as one or more layers extra play outside coating.

Another advantage is, compared with each independent component, the insecticidal activity of the synergy of Pesticidal combination of the present invention；Institute State active sum when insecticidal activity is each applied more than described two active components.This causes the amount for optimizing active component used It is possibly realized.

On the other hand, processing of the invention can also produce following super additive effect：Improve plant growth, improve to high temperature Or low temperature tolerance, improve to arid or to the tolerance of water or soil salt content, improve Flowering quality, make harvesting simpler Just, accelerate ripe, raising harvesting yield, improve the quality of harvested products and/or improve its nutritive value, improve harvested products Bin stability and/or its processing characteristics.

The Pesticidal combination of the present invention can also especially be applied to transgenic seed, and the plant grown up to by the seed being capable of table Up to the albumen directly against insect.This kind of seed is handled by using the Pesticidal combination of the present invention, some insects can only pass through example Prevented and treated such as the expression of insecticidal proteins, and infringement is protected from by the Pesticidal combination of the present invention.

It is common and favourable that the Pesticidal combination of the present invention is generally applied with following dosage：

- for leaf portion processing：0.1-10000g/ha, preferably 10-1000g/ha, more preferably 10-200g/ha；For dipping Or for administration of instiling, the dosage can also even reduce, particularly when applying inert base such as asbestos or pearl rock；

- for seed treatment：2-200g/100kg seeds, preferably 3-150g/100kg seeds；

- for soil treatment：0.1-10000g/ha, preferably 1-5000g/ha.

Above-mentioned dosage is only general exemplary dose, and those skilled in the art can be according to actual feelings when reality is applied Condition and needs, rate of application is adjusted especially in accordance with the property and insect pest situation of pending plant or crop.

Pesticidal combination of the present invention can be provided in the form of finished product preparation, i.e., each material has mixed in composition Close；It can also be provided with unit dose preparation, directly be mixed in bucket (tank) using preceding.The concentrate of the present invention generally mixes with water To the concentration of required active material.

For ease of understanding the present invention, it is as follows that the present invention enumerates embodiment.Those skilled in the art are it will be clearly understood that the implementation Example is only to aid in understanding the present invention, is not construed as the concrete restriction to the present invention.

First, example of formulations

The missible oil of embodiment 1

Said components are mixed to the liquid of transparent and homogeneous, that is, obtain cream preparation.Can be above-mentioned by being diluted with water Concentrate, obtain the emulsion of any required dilute strength available for plant protection.

The wettable powder of embodiment 2

Above-mentioned active component is sufficiently mixed with auxiliary agent, mixture is fully ground in suitable flour mill, and obtaining can WP.It can be diluted with water and the suspension for wishing concentration is provided.

The aqueous emulsion of embodiment 3

Above-mentioned active component is added together with auxiliary agent, makes to be dissolved into homogeneous oil phase；Water-soluble component and water are mixed into system Obtain aqueous phase；Under high velocity agitation, it is oil phase is mixed with water, aqueous emulsion is made.

The water dispersible granules of embodiment 4

Active component, dispersant, wetting agent, disintegrant and filler are well mixed in the ratio of formula, by air-flow powder Wettable powder is broken into, adds a certain amount of water mixing extruder grain, water dispersible granules are obtained after drying and sieving.

The microemulsion of embodiment 5

Said components are mixed to the liquid of transparent and homogeneous, that is, obtain microemulsion.

The seed treatment dry powder doses of embodiment 6

Above-mentioned active component is sufficiently mixed with auxiliary agent, mixture is fully ground in suitable flour mill, and obtaining can It is directly used in the dry powder doses of seed treatment.

The suspension emulsion of embodiment 7

Ivermectin HCL is dissolved in SOLVESSO^TMIn 200, ethoxylated castor oil is added, obtains missible oil；By pyriminostrobin, AEO sulfosuccinic acid monoesters disodium, MODIFIED LIGNOSULPHONATE, xanthans, bentonite, glycerine, water etc. Above-mentioned each component mixes in proportion, and through being sanded, is prepared into containing pyriminostrobin suspending agent.Oil phase containing Ivermectin HCL is added Into the suspending agent of containing pyriminostrobin, suspension emulsion is obtained.

The aqueous emulsion of embodiment 8

Ivermectin HCL and pyriminostrobin are dissolved in methyl oleate, polystyrene is added and obtains oil phase；According in formula Component is well mixed to obtain aqueous phase；Oil phase addition aqueous phase is obtained into aqueous emulsion under agitation.

The wettable powder of embodiment 9

Combinations thereof is mixed in proportion, and ground, crushes, is prepared into wettable powder.

The coated granule of embodiment 10

In a mixer, by levigate active component even spread to the carrier soaked by polyethylene glycol.In this way Dust-free coated granules agent can be obtained.

The wettable powder of embodiment 11

Said components are mixed in proportion, and grinds, crush, are prepared into wettable powder.

Embodiment 12 extrudes granule

Active component is mixed and ground with auxiliary agent, mixture is moistened with water.The mixture is extruded, then in air stream Middle drying, it is prepared into extrusion granule.

The suspension emulsion of embodiment 13

Ivermectin HCL is dissolved in SOLVESSO^TMIn 200, ethoxylated castor oil is added, obtains missible oil；By pyriminostrobin, AEO sulfosuccinic acid monoesters disodium, MODIFIED LIGNOSULPHONATE, xanthans, bentonite, glycerine, water etc. Above-mentioned each component mixes in proportion, and through being sanded, is prepared into suspending agent.Oil phase containing Ivermectin HCL is added to containing phonetic mite In the suspending agent of amine, suspension emulsion is obtained.

The suspension emulsion of embodiment 14

Ivermectin HCL is dissolved in SOLVESSO^TMIn 200, ethoxylated castor oil is added, is obtained containing Ivermectin HCL breast Oil；By pyriminostrobin, AEO sulfosuccinic acid monoesters disodium, MODIFIED LIGNOSULPHONATE, xanthans, swelling The above-mentioned each component such as soil, glycerine, water mixes in proportion, and through being sanded, is prepared into suspending agent.By the oil containing Ivermectin HCL It is added in the suspending agent of containing pyriminostrobin, obtains suspension emulsion.

The microcapsule suspension-suspendinagent agent of embodiment 15

By poly methylene poly phenyl poly isocyanate (PAPI), Ivermectin HCL and SOLVESSO^TM200 oil phases formed add Enter to contain ATLOX^TMIn 4913 aqueous solution, emulsion is formed.Then heat and be incubated at 50 DEG C add catalyst reaction 2 it is small When.The microcapsules containing Ivermectin HCL is obtained after cooling.

ATLOX^TM4913rd, dispersant LFH, defoamer, urea, pyriminostrobin and water mix in proportion, and through being sanded, It is prepared into the suspending agent of containing pyriminostrobin.

The obtained microcapsules containing Ivermectin HCL is added in the aqueous suspension agent of containing pyriminostrobin, micro-capsule is uniformly mixing to obtain and hangs Floating-suspending agent.

The seed treatment suspending agent of embodiment 16

Ivermectin HCL is dissolved in SOLVESSO^TMIn 200, ethoxylated castor oil is added, obtains the breast containing Ivermectin HCL Oil；By pyriminostrobin, AEO sulfosuccinic acid monoesters disodium, MODIFIED LIGNOSULPHONATE, xanthans, the third three The above-mentioned each component such as alcohol, polyvinylpyrrolidone and water mixes in proportion, and through being sanded, is prepared into seed treatment suspension Agent.

Oil phase containing Ivermectin HCL is added in the suspension seed-coating agent of containing pyriminostrobin, obtains seed treatment suspending agent.

The smoke agent of embodiment 17

After component in formula is mixed, granular fumicants is configured to by crushing, and by preprepared spill lead It is positioned in fumicants, obtains smoke agent.

The wettable powder of embodiment 18

Active component, various auxiliary agents and filler etc. are mixed by the proportional components of formula, after ultra-fine pulverizer disintegrating, i.e., Obtain wettable powder.

The suspending agent of embodiment 19

Active component and various auxiliary agents are mixed with water, after high speed shear is scattered, sand mill is sanded, form high score Dissipate, stable suspension system, suspending agent is made.

The missible oil of embodiment 20

The pyriminostrobin of 21 2% Ivermectin HCL of embodiment+98%

Ivermectin HCL 2%

Pyriminostrobin 98%

Ivermectin HCL and pyriminostrobin are mixed in proportion.

2nd, indoor biological is tested

Crop protection products are made in different combination of active principles, be develop and develop at present new crop protection products with And prevent and treat a kind of effective and quick way of agriculturally resistant insect.After the pestsides synthesis of different cultivars, three are typically exhibited Kind type of action：Summation action, synergistic effect and antagonism.But it is specially which kind of effect, it is unpredictable, only by a large amount of Experiment just can know that.Compound synergic is formulated well, due to significantly improving actual prevention effect, reduces the use of agricultural chemicals Amount, it is the important means of integrated control disease so as to greatly delay the generation speed of pest resistance to insecticide.

Inventor by substantial amounts of screening test, Ivermectin HCL and the different ratio of pyriminostrobin have been carried out lot of experiments with And effectiveness analysis, finding in certain ratio range, resulting Pesticidal combination has gain effect, rather than just The simple addition of two kinds of medicaments, is specifically illustrated with implementation below.

It is accurate with reference to the experiment of the People's Republic of China (PRC) agricultural industry criteria (NY/T154.7-2009) farm-chemical indoor determination The then synergy measure of the part mixture of insecticide the 7th, according to survey data, calculate the corrected mortality of each processing, and according to The abundant methods of Sun Yun calculate the co-toxicity coefficient (CTC values) of mixture.

Clear and definite two kinds of medicaments compound by a certain percentage after co-toxicity coefficient (CTC), CTC<80 be to resist effect short of money, 80≤CTC ≤ 120 be summation action, and CTC ＞ 120 are synergistic effect.

Calculation formula is as follows：

Borer population * 100 living before the death rate (%)=(borer population living after borer population-medicine living before medicine)/medicine

Corrected mortality (%)=(the treatment group death rate-control group death rate)/(the 100- control groups death rate) * 100

Probit value (y) will be converted into for examination insect corrected mortality, concentration for the treatment of (μ g/ml) is converted into logarithm value (x), with Least square method calculates concentration LC in suppression₅₀, then according to the abundant method calculating co-toxicity coefficients (CTC) of Sun Yun.

Calculation formula is following, and (using Ivermectin HCL as standard agent, 100) its toxicity index is：

Survey toxicity index (ATI)=(standard agent LC₅₀/ reagent agent LC₅₀)×100

In theoretical toxicity index (TTI)=A medicaments ATI × mixture in A percentage composition+B medicaments ATI × mixture B hundred Divide content

Co-toxicity coefficient (CTC)=(mixture ATI/ mixture TTI) × 100

CTC<80 show as resisting effect short of money, and 80≤CTC≤120 show as summation action, and CTC ＞ 120 show as collaboration and made With.

Experiment 1：To the Toxicity Determination of Kidney bean Tetranychus urticae

Test method is tested with reference to pesticide indoor bioassay test rule NY/T1154.5-2009 ovicidal activities Infusion process.

Kidney bean leaf blade band handle is cut, inserts in plus the peace of water is cutd open in bottle.Connect a number of into mite.Treat into mite spawning After 24h, mite is removed into, the blade with enough ovum is dipped in 10s in decoction, sucks unnecessary decoction with blotting paper rapidly, will Blade is replaced in peace and cutd open in bottle, naturally dry.It is placed in observation ward and cultivates.Experiment is repeated 4 times, and sets blank control, is treated pair Investigated after hatching according to whole.Dead worm is considered as with the young mite that can not hatch and can not normally creep during investigation.

Table 1：Pyriminostrobin is compounded to Kidney bean Tetranychus urticae Toxicity Determination result with Ivermectin HCL

As shown in Table 1, Kidney bean Tetranychus urticae is prevented and treated, pyriminostrobin and Ivermectin HCL are 5:1-200:In the range of 1, poison is altogether Number is all higher than 120, shows synergistic effect.

Experiment 2：To the Toxicity Determination result of panonychus citri

Experiment determines Ivermectin HCL, pyriminostrobin and the two different proportion with reference to NY/T1154.14-2009 leaf dipping methods Combine the indoor biological activity to test worm.

Using the first leaching leaf method that is followed by worm, by not in contact with the blade of the same size of any medicament in the decoction prepared Take out, naturally dry, be put into insect box after middle immersion 5s, then connect for examination larva, raise under the conditions of 25 DEG C, often handle 3 repetitions, it is 20 often to repeat test worm number used, while sets blank control, checks dead borer population in 72h, calculates the death rate and school The positive death rate, try to achieve virulence regression equation and calculate LC₅₀Value.If compareing the death rate is more than 10%, it is considered as invalid experiment.

Table 2：Pyriminostrobin is compounded to panonychus citri Toxicity Determination result with Ivermectin HCL

As known from Table 2, panonychus citri is prevented and treated, pyriminostrobin and Ivermectin HCL are 2:1-200:In the range of 1, co-toxicity coefficient 120 are all higher than, shows synergistic effect.

Experiment 3：To the Toxicity Determination result of cotton Tetranychus cinnabarinus

Table 3：Pyriminostrobin is compounded to cotton Tetranychus cinnabarinus Toxicity Determination result with Ivermectin HCL

As known from Table 3, cotton Tetranychus cinnabarinus is prevented and treated, pyriminostrobin and Ivermectin HCL are 3:1-220:In the range of 1, poison is altogether Number is all higher than 120, shows synergistic effect.

Test the Toxicity Determination result of 4 pairs of pear suckers

Table 4：Pyriminostrobin is compounded to pear sucker Toxicity Determination result with Ivermectin HCL

As known from Table 4, pear sucker is prevented and treated, pyriminostrobin and Ivermectin HCL are 2:1-200:In the range of 1, co-toxicity coefficient is big In 120, synergistic effect is shown.

Experiment 5：To the Toxicity Determination result of apple tree aphid

Table 5：Pyriminostrobin is compounded to apple tree aphid Toxicity Determination result with Ivermectin HCL

As known from Table 5, apple tree aphid is prevented and treated, pyriminostrobin and Ivermectin HCL are 1:1-200:In the range of 1, co-toxicity coefficient 120 are all higher than, shows synergistic effect.

Experiment 6：To the Toxicity Determination result of wild cabbage diamondback moth

Using the first leaching leaf method that is followed by worm, by not in contact with the blade of the same size of any medicament in the decoction prepared Take out, naturally dry, be put into insect box after middle immersion 5s, then connect for examination larva, raise under the conditions of 25 DEG C, often handle 3 repetitions, it is 20 often to repeat test worm number used, while sets blank control, checks dead borer population in 72h, calculates the death rate and school The positive death rate, try to achieve virulence regression equation and calculate LC₅₀Value.If compareing the death rate is more than 10%, it is invalid to be considered as.

Table 6：Pyriminostrobin is compounded to wild cabbage diamondback moth Toxicity Determination result with Ivermectin HCL

As known from Table 6, wild cabbage diamondback moth is prevented and treated, pyriminostrobin and Ivermectin HCL are 1:1-200:In the range of 1, co-toxicity coefficient 120 are all higher than, shows synergistic effect.

Experiment 7：To the Toxicity Determination result of paddy rice rice leaf roller

Table 7：Pyriminostrobin is compounded to paddy rice rice leaf roller Toxicity Determination result with Ivermectin HCL

As known from Table 7, paddy rice rice leaf roller is prevented and treated, pyriminostrobin and Ivermectin HCL are 1:1-200:It is malicious altogether in the range of 1 Coefficient is all higher than 120, shows synergistic effect.

3rd, efficiency test

When the effect of active component composition exceedes the summation of the effect when each active component is administered alone, association be present Same desinsection and acaricidal action.So-called " Colby formula " (ginseng can be used in the predictive role of the particular combination of two kinds of active components See S.R.Colby, " Calculating Synergistic and Antagonistic Responses of Herbicide Combinations ", Weeds1967,15,20-22) it is calculated as below：If

X is when the use of dosage being mg/ha or kill rate during active component A that concentration is mppm, is expressed as accounting for untreated The percentage of control；

Y is when the use of dosage being ng/ha or kill rate during active component B that concentration is nppm, is expressed as accounting for untreated The percentage of control；

E is when the use of dosage being m and n g/ha or kill rate when active component A and B that concentration is m and n ppm, is represented To account for the percentage of untreated control；

If actual desinsection fatal rate exceedes calculated value, the lethal effect of composition is super plus sum, that is, association be present Same-action.In this case, the kill rate actually observed must be over the expection kill rate value calculated using above-mentioned formula (E) value.

Experiment one：The efficiency test of panonychus citri

Experiment is carried out as follows：Test site is Zhejiang Jiaxing, and the time is at the beginning of 5 months.Tested using potted plant citrus, seedling age 3 Year.Every plant of inoculation Panonychus citri is female into mite 200 before spray.Spray processing in 2 days after inoculation.It is defined by squirting leave dual sides, often 3 plants of citrus seedlings of individual processing.25 blades are adopted within 3 days, 10 days, 20 days and 30 days after medicine in the indoor binocular investigation blade of experiment On into mite number, calculate Revision insect recluced rate and prevention effect, formula be as follows：

Specific test method and data are as follows：

Worm living before mite mouth decline rate (%)=(borer population living after borer population-treatment region medicine living before treatment region medicine)/treatment region medicine Number * 100

Prevention effect (%)=(treatment region mite mouth decline rate ± check plot mite mouth decline rate)/(100 ± check plot mite mouth subtracts Move back rate) * 100

Table 8

In terms of the result of the test of table 8, the preventive effect observed after the compounding of Ivermectin HCL and pyriminostrobin is anti-apparently higher than calculating Effect, shows obvious synergistic effect.Ivermectin HCL and pyriminostrobin compounding, which combine, knocks down activity and extends the preventing and treating time, reaches The effect of snap action and long-acting.

Experiment two：The efficiency test of Kidney bean Tetranychus urticae

Experiment is carried out as follows：Test site is Zhejiang Jiaxing, and the time is at the beginning of 6 months.Every plant of two variegated leafs of inoculation before Kidney bean spray Mite 200.Spray processing in 2 days after inoculation.It is defined by squirting leave dual sides, each handles 3 plants of Kidney bean seedlings.3 days after medicine, 10 My god, adopt within 20 days and 30 days 25 blades in test on indoor binocular investigation blade into mite number, calculate Revision insect recluced rate and Prevention effect, formula are as follows：

Specific test method and data are as follows：

Table 9

In terms of the result of the test of table 9, the preventive effect observed after the compounding of Ivermectin HCL and pyriminostrobin is anti-apparently higher than calculating Effect, shows obvious synergistic effect.Ivermectin HCL and pyriminostrobin compounding, which combine, knocks down activity and extends the preventing and treating time, reaches The effect of snap action and long-acting.

Experiment three：The efficiency test of cotton Tetranychus cinnabarinus

Experiment is carried out as follows：Test site is Zhejiang Jiaxing, and the time is at the beginning of 6 months.Every plant of inoculation cinnabar leaf before cotton plant spray Mite 200.Spray processing in 2 days after inoculation.It is defined by squirting leave dual sides, each handles 3 plants of cotton plants.3 days after medicine, 10 My god, adopt within 20 days and 30 days 25 blades in test on indoor binocular investigation blade into mite number, calculate Revision insect recluced rate and Prevention effect, formula are as follows：

Specific test method and data are as follows：

Table 10

In terms of the result of the test of table 10, the preventive effect observed after the compounding of Ivermectin HCL and pyriminostrobin is anti-apparently higher than calculating Effect, shows obvious synergistic effect.Ivermectin HCL and pyriminostrobin compounding, which combine, knocks down activity and extends the preventing and treating time, reaches The effect of snap action and long-acting.

Experiment four：The efficiency test of apple tree aphid

Experiment is carried out as follows：Test site is Zhejiang Jiaxing, and the time is at the beginning of 3 months.Apple tree seedling age is 5 years.It is every before spray Strain inoculation aphid adult 200.Spray processing in 2 days after inoculation.It is defined by squirting leave dual sides, each handles 3 plants of apple trees. 6 days after medicine, adopt 25 blades in test on indoor binocular investigation blade into borer population, calculate Revision insect recluced rate and preventing and treating Effect, formula are as follows：

Specific test method and data are as follows：

Worm living before Revision insect recluced rate (%)=(borer population living after borer population-treatment region medicine living before treatment region medicine)/treatment region medicine Number * 100

Prevention effect (%)=(treatment region Revision insect recluced rate ± check plot Revision insect recluced rate)/(100 ± check plot insect population subtracts Move back rate) * 100

Table 11

In terms of the result of the test of table 11, the preventive effect observed after the compounding of Ivermectin HCL and pyriminostrobin is anti-apparently higher than calculating Effect, shows obvious synergistic effect.

Experiment five：The efficiency test of pear sucker

Experiment is carried out as follows：Test site is Zhejiang Jiaxing, and the time is mid-June.Pear tree seedling age is 5 years.It is every before spray Strain inoculation pear sucker adult 200.Spray processing in 2 days after inoculation.It is defined by squirting leave dual sides, each handles 3 plants of pear trees. 6 days after medicine, adopt 25 blades in test on indoor binocular investigation blade into borer population, calculate Revision insect recluced rate and preventing and treating Effect, formula are as follows：

Specific test method and data are as follows：

Table 12

Active component	Concentration (ppm)	The * that 6 days killing rates are found	6 days killing rate calculated value * *
				Pyriminostrobin	10	13.1	-
Ivermectin HCL	1	21.5	-
				Pyriminostrobin+Ivermectin HCL	10+1	42.2	31.8

In terms of the result of the test of table 12, the preventive effect observed after the compounding of Ivermectin HCL and pyriminostrobin is anti-apparently higher than calculating Effect, shows obvious synergistic effect.

Experiment six：Meloidogyne incognita is tested

Soil, active compounds solution, Meloidogyne incognita (Meloidogyne incognita) ovum/larva are suspended Liquid and Leaf lettuce seed are fitted into container.The Leaf lettuce germination and plant growth.Insect gall is formed on root.Taken Between after, pass through nematocidal effect of the formation measure in terms of % of insect gall.100% represents without discovery insect gall；0% represents through processing Insect gall quantity is suitable with the insect gall quantity of unprocessed control group on plant.

Table 13

Active component	Concentration (ppm)	The * that 21 days killing rates are found	21 days killing rate calculated value * *
				Pyriminostrobin	56.25	0	-
Ivermectin HCL	2.25	85.5	-
				Pyriminostrobin+Ivermectin HCL	56.25+2.25	97.2	85.5

In terms of the result of the test of table 13, the preventive effect observed after the compounding of Ivermectin HCL and pyriminostrobin is anti-apparently higher than calculating Effect, shows obvious synergistic effect.

The present invention can be seen that by after both Ivermectin HCL and pyriminostrobin compounding by above-mentioned experiment, compared with single dose, assist Same-action is obvious, improves insecticidal effect.

Claims

A kind of 1. Pesticidal combination, it is characterised in that its active component is made up of pyriminostrobin and Ivermectin HCL, the pyriminostrobin and The weight proportion of Ivermectin HCL is 1:1-200:1, preferably 1:1-150:1, more preferably 1:1-100:1, preferably 1:1-90:1, it is more excellent Select 1:1-80:1, more preferably 1:1-70:1, more preferably 1:1-60:1, more preferably 1:1-50:1, more preferably 10:1-40:1.
2. Pesticidal combination according to claim 1, it is characterised in that the pyriminostrobin and the total amount of Ivermectin HCL account for institute State composition 1%-90% by weight, more preferably preferably 5%-80%, more preferably 10%-50%, 10%-40%.
3. Pesticidal combination according to claim 1, it is characterised in that the Pesticidal combination also includes surfactant And/or filler.
4. Pesticidal combination according to claim 1, it is characterised in that the formulation of the Pesticidal combination is missible oil, hanged Floating agent, seed treatment dry powder doses, seed treatment suspending agent, water dispersible granules, wettable powder, suspension emulsion, smoke agent, coating Granula, extrusion granule, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent, dry suspending agent or ultra low volume liquids.
5. Pesticidal combination according to claim 1 is used for the purposes for preventing or controlling harmful organism.
6. the Pesticidal combination according to claim 1 is used to prevent or control Insecta (Insecta), Arachnoidea (Arachnida), the purposes of Nematoda (Nematoda).
7. purposes according to claim 5, it is characterised in that the harmful organism is selected from Lepidoptera, Diptera, elytrum Mesh, Semiptera, Homoptera, Orthoptera, Hymenoptera, Isoptera, Siphonaptera, Blattaria, Thysanoptera, Acarina or Meloidogyne.
8. purposes according to claim 5, it is characterised in that the harmful organism is Panonychus citri, Tetranychus cinnabarinus, two variegated leafs Mite, pear sucker, aphid, diamondback moth, rice leaf roller, striped rice borer or root-knot nematode.
A kind of 9. method for protecting useful plant to prevent pest infestation, it is characterised in that：Including by described in claim 1 Pesticidal combination acts on target useful plant or its environment, object noxious livings or its environment, the breeding of target useful plant Material.
10. according to the method for claim 9, it is characterised in that the propagating materials be seedling, rhizome, garden seedling, cutting or Seed.
A kind of 11. method for protecting useful plant to prevent pest infestation, it is characterised in that：Including by described in claim 1 Pesticidal combination and target useful plant or its environment, object noxious livings or its environment, the breeding material of target useful plant Material contact.
A kind of 12. method for protecting useful plant to prevent pest infestation, it is characterised in that：Be included in target useful plant or Its environment, object noxious livings or its environment, target useful plant propagating materials on wish sequentially or simultaneously to apply with any With the pyriminostrobin and Ivermectin HCL in the Pesticidal combination described in claim 1.
13. a kind of prevent and treat or prevent in plant propagation material and in growing plants organ, plant part and/or plant afterwards The method of harmful organism, it is characterised in that：Including by the Pesticidal combination described in claim 1 be applied to plant propagation material or It is environmentally.
A kind of 14. method for protecting seed, seedling root and branch to be attacked to prevent soil and foliar insect, it is characterised in that：Including Seed is set to be contacted with the Pesticidal combination described in claim 1 before sowing and/or after vernalization.
A kind of 15. method for protecting useful plant to prevent pest infestation, it is characterised in that by killing described in claim 1 Active component pyriminostrobin and Ivermectin HCL in worm composition separately or cooperatively act on seed.