CN107510884A - A kind of Silica hydrogel elasticity scar plaster and preparation method thereof - Google Patents
A kind of Silica hydrogel elasticity scar plaster and preparation method thereof Download PDFInfo
- Publication number
- CN107510884A CN107510884A CN201710918728.6A CN201710918728A CN107510884A CN 107510884 A CN107510884 A CN 107510884A CN 201710918728 A CN201710918728 A CN 201710918728A CN 107510884 A CN107510884 A CN 107510884A
- Authority
- CN
- China
- Prior art keywords
- layer
- medical
- medicine
- silicone gel
- scar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 231100000241 scar Toxicity 0.000 title claims abstract description 77
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title claims abstract description 72
- 239000000377 silicon dioxide Substances 0.000 title claims abstract description 36
- 239000011505 plaster Substances 0.000 title claims abstract description 31
- 239000000017 hydrogel Substances 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000003814 drug Substances 0.000 claims abstract description 67
- 239000000499 gel Substances 0.000 claims abstract description 55
- 239000000787 lecithin Substances 0.000 claims abstract description 48
- 229940067606 lecithin Drugs 0.000 claims abstract description 48
- 229920002529 medical grade silicone Polymers 0.000 claims abstract description 46
- 239000004744 fabric Substances 0.000 claims abstract description 32
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 31
- 235000010445 lecithin Nutrition 0.000 claims abstract description 31
- 229920001661 Chitosan Polymers 0.000 claims abstract description 28
- 239000002253 acid Substances 0.000 claims abstract description 17
- 239000002105 nanoparticle Substances 0.000 claims abstract description 16
- 239000000463 material Substances 0.000 claims abstract description 13
- 238000007598 dipping method Methods 0.000 claims abstract description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 81
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- 239000000243 solution Substances 0.000 claims description 27
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 14
- 239000002994 raw material Substances 0.000 claims description 11
- -1 polypropylene Polymers 0.000 claims description 10
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims description 8
- 239000003054 catalyst Substances 0.000 claims description 7
- 235000011187 glycerol Nutrition 0.000 claims description 7
- 244000146462 Centella asiatica Species 0.000 claims description 5
- 235000004032 Centella asiatica Nutrition 0.000 claims description 5
- 239000004743 Polypropylene Substances 0.000 claims description 5
- 229920001155 polypropylene Polymers 0.000 claims description 5
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 5
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 4
- 229920000742 Cotton Polymers 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 239000000835 fiber Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000002525 ultrasonication Methods 0.000 claims description 3
- 238000004945 emulsification Methods 0.000 claims description 2
- 238000006555 catalytic reaction Methods 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 abstract description 16
- 229920001296 polysiloxane Polymers 0.000 abstract description 10
- 230000009471 action Effects 0.000 abstract description 4
- 238000005516 engineering process Methods 0.000 abstract description 4
- 239000011859 microparticle Substances 0.000 abstract description 4
- 206010013786 Dry skin Diseases 0.000 abstract description 3
- 208000003251 Pruritus Diseases 0.000 abstract description 3
- 230000037336 dry skin Effects 0.000 abstract description 3
- 230000004913 activation Effects 0.000 abstract description 2
- 230000003020 moisturizing effect Effects 0.000 abstract description 2
- 230000008439 repair process Effects 0.000 abstract description 2
- 239000010410 layer Substances 0.000 description 105
- 206010052428 Wound Diseases 0.000 description 11
- 208000027418 Wounds and injury Diseases 0.000 description 11
- 210000003491 skin Anatomy 0.000 description 11
- 230000000694 effects Effects 0.000 description 8
- 241000167550 Centella Species 0.000 description 6
- 239000003995 emulsifying agent Substances 0.000 description 5
- 206010020718 hyperplasia Diseases 0.000 description 5
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000002390 hyperplastic effect Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229920002674 hyaluronan Polymers 0.000 description 3
- 229960003160 hyaluronic acid Drugs 0.000 description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000007937 lozenge Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 229920006264 polyurethane film Polymers 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 230000010148 water-pollination Effects 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 230000037314 wound repair Effects 0.000 description 2
- 208000032544 Cicatrix Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 102000016611 Proteoglycans Human genes 0.000 description 1
- 108010067787 Proteoglycans Proteins 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229940045110 chitosan Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000002346 layers by function Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000011897 real-time detection Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 238000001338 self-assembly Methods 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
Abstract
The present invention relates to field of medical article technology, more particularly to a kind of Silica hydrogel elasticity scar plaster and preparation method thereof,, as internal layer, to include medical sponge layer and the flexible backing layer that medical silicone gel layer, hydrophilic yarn layer of cloth, dip loading have medicine successively from inside to outside close to the side of the surface of a wound；The dip loading, which has in the medical sponge layer of medicine, is built-in with air bag, and air bag is connected with aerating device；The medicine of medical sponge layer dipping is the chitosan lecithin nanoparticle for being embedded with medicine；The material that medical silicone gel layer uses is acid medical silicone gel.One side hydrophilic yarn layer of cloth promotes drug microparticles to be transferred to gel layer, on the other hand acid silicone gel promotes the embedding of drug microparticles solution, promote skin at insoluble drug release to scar, activation scar, repair scar, pass through hydrophilic yarn layer of cloth and chitosan double action simultaneously, one layer of moisturizing film is provided to scar, and moisture is provided, mitigate the discomfort such as dry skin itch at scar.
Description
Technical field
The present invention relates to field of medical article technology, and in particular to a kind of Silica hydrogel elasticity scar plaster and preparation method thereof.
Background technology
Scar is change of the caused a kind of normal skin tissue on mode of appearance and histopathology after various wounds,
The formation of scar is the inevitable outcome in processes of wound repair.Clinically, often left behind after patient wound's wound healing serious
Scar, especially hyperplastic scar is very common.Hyperplastic scar is due to fibroblast undue growth, extracellular base
The over-deposit such as proteoglycan, glycoprotein and collagen is formed in matter.A large amount of clinical researches show that skin histology tension force is in wound scar
Played a crucial role in the forming process of trace, tension force is bigger, and the possibility that scar is formed after wound healing is bigger.Therefore, drop is passed through
Low scar surrounding skin tissue tension, it effectively can mitigate or suppress scar hyperplasia.It is clinically at present to use pressure therapy more, such as
Silicone dressing combination pressure garment or elastic sleeve are used in combination, and can prevent the formation of hyperplastic scar to a certain extent, still
Pressure therapy worked only for hyperplastic scar it is very fast, and for other scars such as umbilicate type scar to no effect, in addition, pressure
Therapy is not suitable for the scraggly position such as hand, foot, joint.And the pressure garment or bullet used in pressure therapy
Power set its own resilient can not be controlled effectively as needed, and it is uneven pressure size to be generally present, and wearing is uncomfortable or even difficult
It is inconvenient for use and expensive to endure.
Dispelled scar band and preparation method as the A of Chinese patent CN 104983495 disclose a kind of malleation Silica hydrogel elastic force, including
Elastic band, the medical silicone gel layer of one layer of scar of dispelling is adhered on the elastic band, and the medical silicone gel layer is provided with protection
Layer, two ends of the elastic band are a pair of ventilative fixed elastic band devices.The patent cooperates with work with layer of silicone using promotion layer
With, and combination pressure therapy, promote scar quickly to repair.But the promotion layer of the patent can only pass through slow medicine with layer of silicone
Slow releasing function is at scar, and the time at medicine arrival scar is long and concentration is small, and the recovery for scar needs longer effect week
Phase；And the patented product acts on pressure at scar and reaches effect by elastic band fixation, pressure is excessive in operating process
Easily skin at damage scar, pressure is too small, does not reach effect, elastic band pressure size can not at-once monitor and regulation, not enough
Convenient, intelligence.
Therefore, it is necessary to which structure and component to elastic scar plaster carry out innovative improvement, to adapt to the items of scar reparation
Demand.
The content of the invention
The defects of in order to overcome prior art, can be to wound it is an object of the invention to provide a kind of Silica hydrogel elasticity scar plaster
Face applies pressure, can realize the controllability of insoluble drug release, and drug release rate is fast, disclosure satisfy that wound repair demand, uses
It is convenient, it effectively can mitigate or suppress scar.
In order to realize the above object the present invention adopts the following technical scheme that：
A kind of Silica hydrogel elasticity scar plaster, as internal layer, to include medical silicone gel successively from inside to outside close to the side of the surface of a wound
Layer, hydrophilic yarn layer of cloth, dip loading have medical sponge layer and the flexible backing layer of medicine；The dip loading has the doctor of medicine
With air bag is built-in with spongy layer, air bag is connected with aerating device；
The medicine of medical sponge layer dipping is the chitosan-lecithin nanoparticle for being embedded with medicine；Medical silicone gel layer is adopted
Material is acid medical silicone gel.
Optionally, pH=3-5 of the medical silicone gel layer.
Optionally, it is made in acidity by adding acetic acid for raw material in the medical silicone gel preparation course.
Further, the medical silicone gel is prepared by each raw material of following parts by weight：Dimethione
20 ~ 50 parts, 10 ~ 20 parts of cyclopentasiloxane, 2 ~ 8 parts of silica, 1 ~ 10 part of catalyst, acetic acid 3-8 parts.
In order to ensure each functional layer fully plays its effect, and further lifted medicine dissolving release speed and
Medicine is conducted to the controllability of medical silicone gel layer, and the thickness of the medical silicone gel layer is 0.2-1mm；Medical sponge layer
Thickness be 3-10mm；The thickness of hydrophilic yarn layer of cloth is 0.01-0.5mm.
Optionally, the material that the hydrophilic yarn layer of cloth uses is polypropylene fibre and synthetic cotton blended material.
Optionally, the medicine of the chitosan-lecithin particulate embedding includes Gotu Kola P.E, low molecular weight hyaluronic acid
Sodium, glycerine.
The pressure applied to the surface of a wound monitor and adjust in real time in order to realize, the flexible backing layer is built-in with pressure
Force snesor, pressure sensor are electrically connected with pressure display module.Further, the pressure sensor is electrically connected with pressure
Control module, pressure control module are electrically connected with alarm device, when the pressure of pressure sensor detection is more than setup pressure value
Pressure control module sends signal control alarm device and sounded the alarm.Wherein pressure control module can use PLC controls system
System, program setting maximum pressure value, when the pressure that pressure sensor detects is more than the pressure value of setting, PLC control system
Signal is sent, alarm device receives signal and sounded the alarm.
Optionally, the size of the medical silicone gel layer is more than or equal to medical sponge layer, and the size of flexible backing layer is big
In medical silicone gel layer.
Optionally, the flexible backing layer is partially circumferentially laid with tack coat beyond medical silicone gel layer.
Optionally, the internal layer of the medical silicone gel layer is additionally provided with release film layer.
Optionally, the size of the release film layer is more than flexible backing layer.
Optionally, the material that the flexible backing layer uses is Medical used elastic cloth, elastic polyurethane film, tape stretch, painting
There is one kind in the elastic non-woven cloth of medical pressure sensitive adhesive；The color of flexible backing layer is water white transparency or the colour of skin.
Optionally, the material that the release film layer uses is polypropylene or polyethylene.
Optionally, the release film layer is triangle line film or lozenge film.
The preparation method of above-mentioned Silica hydrogel elasticity scar plaster, it is characterised in that comprise the following steps：
1）Prepare acid medical silicone gel：Dimethione, cyclopentasiloxane, silica, acetic acid is taken to mix equal
After even, catalyst is added, is mixed evenly again, bubble removing, produces acid medical silicone gel；
2）Preparing dip loading has the medical sponge layer of medicine：
A：Take medical sponge to hollow out to form cavity at middle part, air bag is placed in the cavities, air bag is connected by connecting tube and inflated
Device；
B：Using acetic acid chitosan, chitosan acetic acid solution is obtained；Take lecithin, need embedding medicinal dissolving in ethanol, obtain
Lecithin ethanol solution；Under stirring, chitosan acetic acid solution is added dropwise in lecithin ethanol solution, and adds emulsification
Agent, the chitosan-lecithin nanoparticle for being embedded with medicine is then formed by ultrasonication；
C：The chitosan-lecithin nanoparticle injection for being embedded with medicine prepared by step B enter step A making be built-in with gas
In the medical sponge of capsule, obtained dip loading has the medical sponge layer of medicine；
3）Each layer is adhesion-molded：Take step 1）The acid medical silicone gel of preparation is uniformly applied to the following table of hydrophilic yarn layer of cloth
Face, by step 2）The medical sponge layer that the dip loading of preparation has medicine is bonded in the upper surface of hydrophilic yarn layer of cloth, Ran Houzai
Flexible backing layer is bonded in the upper surface of medical sponge layer, 15min~30min is reacted at a temperature of being placed in 70 DEG C~90 DEG C, so
After be transferred under 120 DEG C~150 DEG C temperature conditionss reaction 10min~20min, that is, complete.Accelerate silicone gel by heating
It is molded in hydrophilic yarn layer of cloth lower surface.
Optionally, embedding medicinal is needed to be made up of the raw material of following parts by weight in step B：Gotu Kola P.E 5-10 parts,
Low molecular weight hyaluronic acid 0.5-2 parts, glycerine 5-10 parts；
The mass percentage concentration of chitosan acetic acid solution is 2% in step B；The mass concentration of lecithin is in lecithin soln
20g/L, the mass concentration for needing embedding medicinal are 5mg/mL；The volumetric usage ratio of chitosan acetic acid solution and lecithin ethanol solution
For 1：6；
Emulsifying agent in step B is Tween 80；The quality dosage of emulsifying agent is 1.2%.
Silica hydrogel elasticity scar plaster of the present invention, has the advantages that compared with prior art：
1st, elastic band and medical sponge layer compounding use, dual-pressure at scar is given, promotes scar reparation；
2nd, air bag and pharmaceutical-impregnated medical sponge are used cooperatively, and are inflated by internal airbag, air bag increase, compress pharmaceutical-impregnated
Medical sponge layer, make to treat scar insoluble drug release in sponge, while increase tension force at scar, not only pressurizeed but also be administered, and pass through
Air bag pressurization administration, had both improved the shortcomings that existing scar plaster medicament slow release is slow, and the action period is long, moreover it is possible to avoid by pumping
It is administered continuously, control drug concentration is excessive to produce the risk stimulated to skin at scar, reaches treatment scar effect；
3rd, further, miniature pressure cell is used cooperatively with air bag, both can constantly monitor the Tensity size given at scar,
Also inflation can be evacuated by air bag to adjust Tensity size.Can be according to miniature pressure cell in flexible backing layer in operating process
To adjust medical sponge layer tension force, if pressure sensor is alarmed, display pressure is excessive, can be evacuated with balloon interface, reduces wound
If tension force pressure is too small at mouthful, inflated with balloon interface, increase wound tension force, and discharge medicine；
4th, on the one hand the load carriers as silicone gel, the another aspect present invention are used as bone to hydrophilic yarn layer of cloth using chitosan
Frame material, by introducing lecithin hydrophobic grouping, its self aggregation under the conditions of aqueous phase is assembled, tool is formed after rearranged
There is the nanoparticle of hydrophily shell and hydrophobic inner core, therefore hydrophilic gauze layer can attract outside with hydrophily
The chitosan-lecithin nanoparticle of shell is conducted into silicone gel, is produced guide functions to sponge drug particles, is carried
Rise drug release rate；A wet environment also is provided for skin at scar simultaneously, mitigates the discomfort such as dry skin itch at scar；
5th, by the way that medicine is wrapped up into chitosan lecithin particulate, the stability of medicine is on the one hand increased;On the other hand due to
Lechitin-chitosan nanoparticle formation basic theory is that chitosan is positively charged, and lecithin is negatively charged, therefore in certain limit just
Negative electrical charge, which be combined with each other, is self-assembly of nanoparticle, in sour environment, H+Concentration increases, most of phosphoric acid in lecithin
The anion of group is by H+Occupy, the electrostatic attraction destroyed between chitosan and lecithin, cause the release of entrapped drug, therefore
The present invention uses acid medical silicone gel, for example adds acetic acid, promotes drug microparticles to discharge into silicone gel and skin, together
When due to the good antibacterial, anti-inflammatory of chitosan, performance of keeping humidity, can prevent from infecting at scar, and give skin to provide a moist ring
Border, promote scar reparation；Lecithin is the main component of cell membrane, has very strong biocompatibility with cell, can increase medicine
The stability and Transdermal absorption ability of thing, promote the absorption of the drug ingedients such as centella；
6th, the drug ingedient such as Gotu Kola P.E, low molecular weight hyaluronic acid and glycerine and chitosan, lecithin are used cooperatively, and are both sent out
Wave Gotu Kola P.E to stimulate circulation, improve the advantageous effect of cutaneous pigmentation at scar, further through low point of lecithin
The absorption of sub- hyaluronic acid Penetration enhancing effect increase centella, increase centella, chitosan action effect, and also lecithin is except tool
Have and promote outside osmotic effect, also there is the formation for promoting epidermis lipid barrier, be advantageous to epidermis recovery, promote scar reparation.
In a word, the present invention will be embedded with the chitosan-lecithin nanoparticle dip loading of medicine medical sponge layer, with
Acid silicone gel, hydrophilic yarn layer of cloth compounding use, produce synergy, and one side hydrophilic yarn layer of cloth promotes medicine micro-
Grain is transferred to gel layer, and on the other hand acid silicone gel promotes the embedding of drug microparticles solution, promotes skin at insoluble drug release to scar
Skin, activation scar, scar is repaired, while by hydrophilic yarn layer of cloth and chitosan double action, one layer of moisturizing is provided to scar
Film, and moisture is provided, mitigate the discomfort such as dry skin itch at scar.
Brief description of the drawings
Fig. 1 is the overall structure diagram of elastic scar plaster provided in an embodiment of the present invention.
Embodiment
The particle size for the chitosan-lecithin nanoparticle of medicine that what is prepared in following embodiments be embedded with for 120~
160nm；The pore size of hydrophilic yarn layer of cloth is 0.4-1um；
The material that hydrophilic yarn layer of cloth uses in following embodiments forms for polypropylene fibre and artificial cotton blend；Flexible backing layer
The material used for Medical used elastic cloth, elastic polyurethane film, tape stretch, scribble in the elastic non-woven cloth of medical pressure sensitive adhesive one
Kind；The color of flexible backing layer is water white transparency or the colour of skin；The material that the release film layer uses is polypropylene or polyethylene；From
Type film layer is triangle line film or lozenge film.
The concrete structure of the Silica hydrogel elasticity scar plaster provided in following embodiments is as shown in figure 1, with close to the one of the surface of a wound
Side is internal layer, and including release film layer 10, medical silicone gel 9, hydrophilic yarn layer of cloth 7, dip loading successively from inside to outside has medicine
The medical sponge layer 4 of thing and flexible backing layer 1；Dip loading, which has, is built-in with air bag 5 in the medical sponge layer 4 of medicine, air bag 5 connects
It is connected to aerating device 6；
The size of hydrophilic yarn layer of cloth 7 is more than the size of medical sponge layer 4, and hydrophilic yarn layer of cloth 7 exceeds the portion of medical sponge layer 4
Divide and be circumferentially provided with gauze tack coat 8, for hydrophilic yarn layer of cloth 7, flexible backing layer 4 and medical sponge layer 1 to be bonded as into one
Body；
The size of flexible backing layer 1 is more than medical silicone gel layer 9, and flexible backing layer 1 exceeds the part of medical silicone gel layer 9
Tack coat 3 is circumferentially provided with, for whole Silica hydrogel elasticity scar plaster to be fixed on into the surface of a wound.
The medicine of medical sponge layer dipping 4 is the chitosan-lecithin nanoparticle for being embedded with medicine；Medical silicone gel
The material that layer 9 uses is acid medical silicone gel.
The thickness of medical silicone gel layer is 0.2-1mm；The thickness of medical sponge layer is 3-10mm；Hydrophilic yarn layer of cloth
Thickness is 0.01-0.5mm.
The pressure applied to the surface of a wound monitor and adjust in real time in order to realize, flexible backing layer 1 is built-in with pressure
Sensor 2, pressure sensor 2 are electrically connected with pressure display module.Further, pressure sensor is electrically connected with Stress control
Module, pressure control module are electrically connected with alarm device, the pressure when the pressure of pressure sensor detection is more than setup pressure value
Control module sends signal control alarm device and sounded the alarm.Wherein pressure control module can use PLC control system, journey
Sequence sets maximum pressure value, and when the pressure that pressure sensor detects is more than the pressure value of setting, PLC control system sends letter
Number, alarm device receives signal and sounded the alarm.
Embodiment 1
The medical silicone gel of the present embodiment Silica hydrogel elasticity scar plaster is prepared by each raw material of following parts by weight：Poly- two
35 parts of first siloxanes, 15 parts of cyclopentasiloxane, 5 parts of silica, 5 parts of catalyst, 5 parts of acetic acid；
The medicine for being embedded with the chitosan-lecithin particulate embedding of medicine is made up of the raw material of following parts by weight：Centella carries
Take 5 parts of thing, 0.5 part of low-numerator sodium hyaluronate, 5 parts of glycerine.
The preparation method of the present embodiment Silica hydrogel elasticity scar plaster, it is characterised in that comprise the following steps：
1）Prepare acid medical silicone gel：Ratio takes dimethione, cyclopentasiloxane, silica, vinegar by weight
After acid is mixed evenly, catalyst is added, is mixed evenly again, the bubble removing by the way of ultrasonic wave, produces acidity
Medical silicone gel；
2）Preparing dip loading has the medical sponge layer of medicine：
A：Medical sponge is taken to hollow out to form cavity at middle part, cavity left and right ends are apart from the corresponding left and right lateral edges of medical sponge
Distance be 5cm, the distance of upper and lower ends both sides above and below medical sponge is 10cm, by air bag place in the cavities, air bag
Aerating device is connected by connecting tube；
B：Using acetic acid chitosan, the chitosan acetic acid solution that mass concentration is 2% is obtained；Take lecithin, need embedding medicinal molten
Solution in ethanol, obtains lecithin ethanol solution, and the mass concentration of lecithin is 20g/L, need to embed medicine in lecithin ethanol solution
The mass concentration of thing is 5mg/mL；The bubble removed in chitosan acetic acid solution is stood, under stirring, utilizes syringe
（Injection needle d=0.7mm）, chitosan acetic acid solution is added dropwise in lecithin ethanol solution, chitosan acetic acid solution and lecithin
The volumetric usage ratio of fat ethanol solution is 1：6, and the emulsifier tween 80 of 1.2% dosage is added, then formed by ultrasonication
It is embedded with the chitosan-lecithin nanoparticle of medicine；
C：The chitosan-lecithin nanoparticle injection for being embedded with medicine prepared by step B enter step A making be built-in with gas
In the medical sponge of capsule, obtained dip loading has the medical sponge layer of medicine；
3）Each layer is adhesion-molded：Take step 1）The acid medical silicone gel of preparation is uniformly applied to the following table of hydrophilic yarn layer of cloth
Face, by step 2）The medical sponge layer that the dip loading of preparation has medicine is bonded in the upper surface of hydrophilic yarn layer of cloth, Ran Houzai
Flexible backing layer is bonded in the upper surface of medical sponge layer, 15min~30min is reacted at a temperature of being placed in 70 DEG C~90 DEG C, so
After be transferred under 120 DEG C~150 DEG C temperature conditionss reaction 10min~20min, then smear bonding on the periphery of flexible backing layer
Agent, release film layer covering is bonded on medical silicone gel layer, that is, completed.
Embodiment 2
The medical silicone gel of the present embodiment Silica hydrogel elasticity scar plaster is prepared by each raw material of following parts by weight：Poly- two
20 parts of first siloxanes, 10 parts of cyclopentasiloxane, 2 parts of silica, 1 part of catalyst, 3 parts of acetic acid；
The medicine for being embedded with the chitosan-lecithin particulate embedding of medicine is made up of the raw material of following parts by weight：Centella carries
Take 10 parts of thing, 2 parts of low-numerator sodium hyaluronate, 10 parts of glycerine.
The preparation method of the present embodiment Silica hydrogel elasticity scar plaster as different from Example 1, chitosan acetic acid in step B
The mass percentage concentration of solution is 2%；The mass concentration of lecithin is 20g/L, needs the quality of embedding medicinal dense in lecithin soln
Spend for 5mg/mL；The volumetric usage ratio of chitosan acetic acid solution and lecithin ethanol solution is 1：6；The dosage of emulsifying agent is
1.2%。
Embodiment 3
The medical silicone gel of the present embodiment Silica hydrogel elasticity scar plaster is prepared by each raw material of following parts by weight：Poly- two
50 parts of first siloxanes, 20 parts of cyclopentasiloxane, 8 parts of silica, 10 parts of catalyst, 8 parts of acetic acid；
The medicine for being embedded with the chitosan-lecithin particulate embedding of medicine is made up of the raw material of following parts by weight：Centella carries
Take 7 parts of thing, 1 part of low-numerator sodium hyaluronate, 7.5 parts of glycerine.
The preparation method of the present embodiment Silica hydrogel elasticity scar plaster as different from Example 1, chitosan acetic acid in step B
The mass percentage concentration of solution is 2%；The mass concentration of lecithin is 20g/L, needs the quality of embedding medicinal dense in lecithin soln
Spend for 5mg/mL；The volumetric usage ratio of chitosan acetic acid solution and lecithin ethanol solution is 1：6；The dosage of emulsifying agent is
1.2%。
It should be noted that release film layer is set to be used to protect on the Silica hydrogel elasticity scar plaster provided in above-described embodiment
Scar plaster, it is avoided to be contaminated；Pressure sensor and pressure control module are to realize the real-time detection and alarm of pressure
Function.Release film layer and pressure control module can be saved according to the application scenario of reality in actual application, fall within this
The protection domain of invention.Meanwhile the restriction for the thickness of each layer is in order to preferably play the function of each layer, in practical application
During those skilled in the art's thickness that can adjust each layer according to being actually needed, the thickness of each layer do not formed to the technology of the present invention
The restriction of scheme.
Embodiments of the present invention are elaborated above in conjunction with drawings and examples, but the present invention is not limited to
Above-mentioned embodiment, in those of ordinary skill in the art's possessed knowledge, present inventive concept can also not departed from
On the premise of changed or changed.
Claims (10)
1. a kind of Silica hydrogel elasticity scar plaster, it is characterised in that, as internal layer, to include successively from inside to outside close to the side of the surface of a wound
Medical silicone gel layer, hydrophilic yarn layer of cloth, dip loading have medical sponge layer and the flexible backing layer of medicine；The dipping is negative
It is loaded with the medical sponge layer of medicine and is built-in with air bag, air bag is connected with aerating device；
The medicine of medical sponge layer dipping is the chitosan-lecithin nanoparticle for being embedded with medicine；Medical silicone gel layer is adopted
Material is acid medical silicone gel.
2. Silica hydrogel elasticity scar plaster as claimed in claim 1, it is characterised in that pH=3- of the medical silicone gel layer
5。
3. Silica hydrogel elasticity scar plaster as claimed in claim 1, it is characterised in that in the medical silicone gel preparation course
Make it in acidity by adding acetic acid for raw material.
4. Silica hydrogel elasticity scar plaster as claimed in claim 3, it is characterised in that the medical silicone gel is by following weight
Each raw material of number is prepared：20 ~ 50 parts of dimethione, 10 ~ 20 parts of cyclopentasiloxane, 2 ~ 8 parts of silica, catalysis
1 ~ 10 part of agent, acetic acid 3-8 parts.
5. Silica hydrogel elasticity scar plaster as claimed in claim 4, it is characterised in that the thickness of the medical silicone gel layer is
0.2-1mm；The thickness of medical sponge layer is 5-10mm；The thickness of hydrophilic yarn layer of cloth is 0.01-0.5mm.
6. the Silica hydrogel elasticity scar plaster as any one of claim 1 ~ 5, it is characterised in that the hydrophilic yarn layer of cloth
The material used forms for polypropylene fibre and artificial cotton fiber's blending.
7. the Silica hydrogel elasticity scar plaster as described in any one of claim 1 ~ 5, it is characterised in that the chitosan-lecithin
The medicine of particulate embedding includes Gotu Kola P.E, low-numerator sodium hyaluronate, glycerine.
8. the Silica hydrogel elasticity scar plaster as described in any one of claim 1 ~ 5, it is characterised in that built in the flexible backing layer
There is pressure sensor, pressure sensor is electrically connected with pressure display module.
9. the Silica hydrogel elasticity scar plaster as described in any one of claim 1 ~ 5, it is characterised in that the hydrophilic yarn layer of cloth
Size is more than or equal to medical sponge layer, and the size of flexible backing layer is more than medical silicone gel layer；Flexible backing layer is beyond medical
Silicone gel is partially circumferentially laid with tack coat.
10. a kind of preparation method of Silica hydrogel elasticity scar plaster as claimed in claim 5, it is characterised in that including following step
Suddenly：
1）Prepare acid medical silicone gel：Dimethione, cyclopentasiloxane, silica, acetic acid is taken to mix equal
After even, catalyst is added, is mixed evenly again, bubble removing, produces acid medical silicone gel；
2）Preparing dip loading has the medical sponge layer of medicine：
A：Take medical sponge to hollow out to form cavity at middle part, air bag is placed in the cavities, air bag is connected by connecting tube and inflated
Device；
B：Using acetic acid chitosan, chitosan acetic acid solution is obtained；Take lecithin, need embedding medicinal dissolving in ethanol, obtain
Lecithin ethanol solution；Under stirring, chitosan acetic acid solution is added dropwise in lecithin ethanol solution, and adds emulsification
Agent, the chitosan-lecithin nanoparticle for being embedded with medicine is then formed by ultrasonication；
C：The chitosan-lecithin nanoparticle injection for being embedded with medicine prepared by step B enter step A making be built-in with gas
In the medical sponge of capsule, obtained dip loading has the medical sponge layer of medicine；
3）Each layer is adhesion-molded：Take step 1）The acid medical silicone gel of preparation is uniformly applied to the following table of hydrophilic yarn layer of cloth
Face, by step 2）The medical sponge layer that the dip loading of preparation has medicine is bonded in the upper surface of hydrophilic yarn layer of cloth, Ran Houzai
Flexible backing layer is bonded in the upper surface of medical sponge layer, 15min~30min is reacted at a temperature of being placed in 70 DEG C~90 DEG C, so
After be transferred under 120 DEG C~150 DEG C temperature conditionss reaction 10min~20min, that is, complete.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710918728.6A CN107510884A (en) | 2017-09-30 | 2017-09-30 | A kind of Silica hydrogel elasticity scar plaster and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710918728.6A CN107510884A (en) | 2017-09-30 | 2017-09-30 | A kind of Silica hydrogel elasticity scar plaster and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107510884A true CN107510884A (en) | 2017-12-26 |
Family
ID=60727050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710918728.6A Pending CN107510884A (en) | 2017-09-30 | 2017-09-30 | A kind of Silica hydrogel elasticity scar plaster and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107510884A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108295369A (en) * | 2018-01-31 | 2018-07-20 | 余道逍 | A kind of medical face moisture-keeping auxiliary mask |
| CN108379724A (en) * | 2018-01-31 | 2018-08-10 | 余道逍 | A kind of medical night humidification system and its control method |
| CN109260503A (en) * | 2018-09-30 | 2019-01-25 | 振德医疗用品股份有限公司 | A kind of absorbing material and preparation method thereof, the dressing comprising the material |
| CN109998778A (en) * | 2019-05-07 | 2019-07-12 | 广州市第八人民医院 | A kind of band pressure medical application suit |
| CN110917177A (en) * | 2019-02-26 | 2020-03-27 | 山东煜和堂药业有限公司 | Hyperplastic scar plaster and its making method |
| CN114712334A (en) * | 2022-04-08 | 2022-07-08 | 季华实验室 | A gel patch for treating traumatic injury, and its preparation method |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1663560A (en) * | 2004-03-03 | 2005-09-07 | 杭州民生药业集团有限公司 | Transdermal drug administering system |
| CN201015652Y (en) * | 2007-01-19 | 2008-02-06 | 宋保生 | Skin burn concrescence paste |
| CN101239041A (en) * | 2008-03-18 | 2008-08-13 | 天津大学 | High molecule liposome and uses thereof |
| CN201822966U (en) * | 2010-10-30 | 2011-05-11 | 中国人民解放军第四军医大学 | External paster for treating skin soft tissue infection |
| CN201832026U (en) * | 2010-04-02 | 2011-05-18 | 李汉穆 | Medicine feeding device for external treatment |
| CN103495155A (en) * | 2013-09-25 | 2014-01-08 | 南阳市汇博生物技术有限公司 | Film for hyperplastic scar repair and preparation method thereof |
| CN203749693U (en) * | 2014-01-21 | 2014-08-06 | 山东省千佛山医院 | Leg medicine compress strap |
| CN104983495A (en) * | 2015-08-10 | 2015-10-21 | 南阳市汇博生物技术有限公司 | Positive pressure silicon gel elastic scar eliminating band and preparation method thereof |
| CN208511708U (en) * | 2017-09-30 | 2019-02-19 | 河南汇博医疗股份有限公司 | A kind of Silica hydrogel elasticity scar plaster |
-
2017
- 2017-09-30 CN CN201710918728.6A patent/CN107510884A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1663560A (en) * | 2004-03-03 | 2005-09-07 | 杭州民生药业集团有限公司 | Transdermal drug administering system |
| CN201015652Y (en) * | 2007-01-19 | 2008-02-06 | 宋保生 | Skin burn concrescence paste |
| CN101239041A (en) * | 2008-03-18 | 2008-08-13 | 天津大学 | High molecule liposome and uses thereof |
| CN201832026U (en) * | 2010-04-02 | 2011-05-18 | 李汉穆 | Medicine feeding device for external treatment |
| CN201822966U (en) * | 2010-10-30 | 2011-05-11 | 中国人民解放军第四军医大学 | External paster for treating skin soft tissue infection |
| CN103495155A (en) * | 2013-09-25 | 2014-01-08 | 南阳市汇博生物技术有限公司 | Film for hyperplastic scar repair and preparation method thereof |
| CN203749693U (en) * | 2014-01-21 | 2014-08-06 | 山东省千佛山医院 | Leg medicine compress strap |
| CN104983495A (en) * | 2015-08-10 | 2015-10-21 | 南阳市汇博生物技术有限公司 | Positive pressure silicon gel elastic scar eliminating band and preparation method thereof |
| CN208511708U (en) * | 2017-09-30 | 2019-02-19 | 河南汇博医疗股份有限公司 | A kind of Silica hydrogel elasticity scar plaster |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108295369A (en) * | 2018-01-31 | 2018-07-20 | 余道逍 | A kind of medical face moisture-keeping auxiliary mask |
| CN108379724A (en) * | 2018-01-31 | 2018-08-10 | 余道逍 | A kind of medical night humidification system and its control method |
| CN109260503A (en) * | 2018-09-30 | 2019-01-25 | 振德医疗用品股份有限公司 | A kind of absorbing material and preparation method thereof, the dressing comprising the material |
| CN110917177A (en) * | 2019-02-26 | 2020-03-27 | 山东煜和堂药业有限公司 | Hyperplastic scar plaster and its making method |
| CN110917177B (en) * | 2019-02-26 | 2023-01-24 | 山东煜和堂药业有限公司 | Hyperplastic scar plaster and its making method |
| CN109998778A (en) * | 2019-05-07 | 2019-07-12 | 广州市第八人民医院 | A kind of band pressure medical application suit |
| CN114712334A (en) * | 2022-04-08 | 2022-07-08 | 季华实验室 | A gel patch for treating traumatic injury, and its preparation method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107510884A (en) | A kind of Silica hydrogel elasticity scar plaster and preparation method thereof | |
| Zarrintaj et al. | Can regenerative medicine and nanotechnology combine to heal wounds? The search for the ideal wound dressing | |
| Saghazadeh et al. | Drug delivery systems and materials for wound healing applications | |
| AU2017382407B2 (en) | Devices and methods for wound treatment | |
| CN206214465U (en) | Skin or surface of a wound combine dressing and its external member | |
| CN106456569A (en) | Device for delivery of skin care composition | |
| Zhou et al. | Rational design of intelligent and multifunctional dressing to promote acute/chronic wound healing | |
| KR20070105331A (en) | Device method, and use for treatment of neuropathy involving nitric oxide | |
| CN103520783A (en) | Systems for providing fluid flow to tissues | |
| CN103768650A (en) | Wound regenerating and repairing bandage and manufacture method thereof | |
| KR101661353B1 (en) | Preparation method of hydrogel mask pack having supply control function of a single or different skin active ingredients | |
| CN107496972B (en) | Anti-adhesion wet dressing for promoting healing of burn wound and preparation method thereof | |
| KR100542875B1 (en) | Hydrogel dressings for wound dressings or packs and its preparation | |
| Hampton et al. | Healing an intractable wound using bio-electrical stimulation therapy | |
| MX2007003206A (en) | Wound care dressing and method using same. | |
| CN208389182U (en) | A kind of elasticity scar plaster | |
| CN204017156U (en) | A kind of far-infrared magnet therapeutic healing accelerating dressing | |
| CN208511708U (en) | A kind of Silica hydrogel elasticity scar plaster | |
| CN104983495A (en) | Positive pressure silicon gel elastic scar eliminating band and preparation method thereof | |
| CN107375994A (en) | A kind of medical gel adhesive bandage product preparation method | |
| Gürtler et al. | Electrospun fibers for the treatment of skin diseases | |
| CN206214441U (en) | A kind of course for the treatment of topical application of drug patch | |
| CN208259842U (en) | A kind of sugar kidney bowel lavage antiseepage dressing | |
| WO2017134573A1 (en) | Resorbable preparation for medical applications, and characteristic uses for said preparation | |
| CN202458908U (en) | Novel band-aid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |