CN107510627A - A kind of anti-ageing gold goal frost - Google Patents

A kind of anti-ageing gold goal frost Download PDF

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CN107510627A
CN107510627A CN201710671443.7A CN201710671443A CN107510627A CN 107510627 A CN107510627 A CN 107510627A CN 201710671443 A CN201710671443 A CN 201710671443A CN 107510627 A CN107510627 A CN 107510627A
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skin
frost
extract
gold goal
nmf
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何维
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/673Vitamin B group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Birds (AREA)
  • Epidemiology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to a kind of anti-ageing gold goal frost, by mass percentage, it includes following components:Glycerine 5%~9%, Xanthan Gum 1.5%~9% and deionized water 50%~75%, EGF stostes 1.1%~2.8%, oat polypeptide 1.2%~2.8%, glycine betaine stoste 1.0%~3.0%, panthenol 0.05%~0.5%, aloe essential oil 0.01%~0.15% and tocopherol acetate 0.5%~3.0%, NMF 1.0%~3.0%, Carlina acaulis extract 1.0%~3.0%, Leonurus extract 1.0%~3.0%, saualane 1.0%~10%, niacinamide 0.5%~2.0% and preservative 0.1%~0.6%, because contain EGF stostes, so that this face cream has repairing hyperplasia skin surface cell, epidermal cell is set to become full, recover the function of younger state.

Description

A kind of anti-ageing gold goal frost
Technical field
The present invention relates to daily chemical products technical field, more particularly to a kind of anti-ageing gold goal frost.
Background technology
The aging of human body is the inexorable law of life growth, wherein the most obvious with the change of skin, general women is 25 After year, skin is in falling tendency, and after 30 years old, aging makes first appearance.Skin senescence refers to that skin surface is coarse and wrinkles Line.
Specifically, the form of skin senescence is mainly that naturally-aged (i.e. endogenous aging) and light aging are (i.e. exogenous Aging), naturally-aged is mainly caused by body inherent cause, is limited to systemic sites, hence it is evident that is characterized as wrinkle and relaxation, and occurs Phenomena such as pigmentation.Light aging is mainly the skin senescence caused by ultraviolet damage accumulation, is that naturally-aged and ultraviolet shine Coefficient result is penetrated, is limited to skin exposure portion, is mainly characterized by pachylosis tarnish, steady overstriking is walked and deepens, pigment Calmness is deepened, and skin microcirculation is deteriorated, elastosis, and epidermis shows as removing power, collagen and elastin laminin synthesis Ability and immunity degradation, phenomena such as dermis thickness is thinning, easy generation allergy inflammation.
Skin aging is a progressive physiology course, and the various factors comprehensive function such as heredity, environment, social mentality Result.As the improvement of people's living standards, the functional requirement more and more higher to skin care item, possesses the skin care of anti-aging effects Product also emerge in an endless stream.Face cream, it is a kind of skin care item of the high nutrition composition added with concentration, according to the specific aim of its formula, tool Have it is anti-ageing, crease-resistant, compact, moisturizing, Bearberry Extract.Moisten reparation face cream as the Este Lauder in the fashionable world are immediately special, The compound face cream of sisley polywaters, Jason Natural esterification C whitening anti-aging perfection face creams etc..Added in these product compositions A variety of concentration elite, while more preservatives are also with the addition of, the preservative of especially easy sensitization, such as dibutyl hydroxy toluene And phenmethylol.Therefore, it is very urgent to seek safer, milder, more effective skin care item.
The content of the invention
It is an object of the invention to overcome the deficiencies of the prior art and provide a kind of anti-ageing gold goal frost, technical side of the invention Case, its to skin can face-beautifying sanility-delaying, enhance metabolism, Cucumber Extract cell, improve microcirculation, increase skin it is close Degree.
The purpose of the present invention is achieved through the following technical solutions:
A kind of anti-ageing gold goal frost, it is characterised in that by mass percentage, it includes following components:Glycerine 5%~9%, Xanthan Gum 1.5%~9% and deionized water 50%~75%, EGF stostes 1.1%~2.8%, oat polypeptide 1.2%~ 2.8%, glycine betaine stoste 1.0%~3.0%, panthenol 0.05%~0.5%, aloe essential oil 0.01%~0.15% and tocopherol Acetic acid esters 0.5%~3.0%, NMF 1.0%~3.0%, Carlina acaulis extract 1.0%~3.0%, Leonurus extract 1.0%~3.0%, saualane 1.0%~10%, niacinamide 0.5%~2.0% and preservative 0.1%~0.6%.
According to a preferred embodiment, by mass percentage, it includes following components:Glycerine 6%~8%, it is yellow Unit cell polysaccharide 2%~8% and deionized water 60%~70%, EGF stostes 1.2%~2.0%, oat polypeptide 1.2%~ 2.0%, glycine betaine stoste 1.5%~2.5%, panthenol 0.1%~0.3%, essential oil 0.05%~0.12% and tocopheryl acetate Ester 0.7%~1.5%, NMF 1.5%~2.5%, Carlina acaulis extract 1.5%~2.5%, Leonurus extract 1.5% ~2.5%, saualane 2%~8%, niacinamide 0.7%~1.5% and preservative 0.2%~0.5%.
According to a preferred embodiment, by mass percentage, it includes following components:Glycerine 7%, yellow unit cell are more Sugar 3.2% and deionized water 59.3%, EGF stostes 1.5%, oat polypeptide 15%, glycine betaine stoste 2.0%, panthenol 0.2%, Essential oil 0.10% and tocopherol acetate 1.0%, NMF 2.0%, Carlina acaulis extract 2.0%, Leonurus extract 2.0%, saualane 3.2%, niacinamide 1.2% and preservative 0.3%.
According to a preferred embodiment, the NMF is xylitol glucoside, anhydro xylitol and xylitol Mixture, the mass ratio of three is (0.3~3) (0.5~4):1.
According to a preferred embodiment, the preservative is Phenoxyethanol, methyl hydroxybenzoate, ethyl hydroxy benzoate and yellow unit cell At least one of polysaccharide.
Compared with prior art, beneficial effects of the present invention are:
1st, technical scheme is used, because containing EGF stostes so that this face cream has repairing hyperplasia skin surface Cell, epidermal cell is set to become function that is full, recovering younger state.It can also promote collagen growth ability, repair The collagen elastomer of aging fracture.
2nd, because containing oat polypeptide in this face cream so that this facial mask has the content of collagen in increase skin, increases The effect of strong skin elasticity.
Embodiment
Technical scheme is detailed further below, but protection scope of the present invention is not limited to following institute State.
Embodiment:
A kind of anti-ageing gold goal frost, it is characterised in that by mass percentage, it includes following components:Glycerine 5%~9%, Xanthan Gum 1.5%~9% and deionized water 50%~75%, EGF stostes 1.1%~2.8%, oat polypeptide 1.2%~ 2.8%, glycine betaine stoste 1.0%~3.0%, panthenol 0.05%~0.5%, aloe essential oil 0.01%~0.15% and tocopherol Acetic acid esters 0.5%~3.0%, NMF 1.0%~3.0%, Carlina acaulis extract 1.0%~3.0%, Leonurus extract 1.0%~3.0%, saualane 1.0%~10%, niacinamide 0.5%~2.0% and preservative 0.1%~0.6%.
Preferably, by mass percentage, it includes following components:Glycerine 6%~8%, Xanthan Gum 2%~8% With deionized water 60%~70%, EGF stostes 1.2%~2.0%, oat polypeptide 1.2%~2.0%, glycine betaine stoste 1.5% ~2.5%, panthenol 0.1%~0.3%, essential oil 0.05%~0.12% and tocopherol acetate 0.7%~1.5%, NMF 1.5%~2.5%, Carlina acaulis extract 1.5%~2.5%, Leonurus extract 1.5%~2.5%, saualane 2%~ 8%, niacinamide 0.7%~1.5% and preservative 0.2%~0.5%.
Further, by mass percentage, it includes following components:Glycerine 7%, Xanthan Gum 3.2% and goes Ionized water 59.3%, EGF stostes 1.5%, oat polypeptide 15%, glycine betaine stoste 2.0%, panthenol 0.2%, the He of essential oil 0.10% Tocopherol acetate 1.0%, NMF 2.0%, Carlina acaulis extract 2.0%, Leonurus extract 2.0%, saualane 3.2%, niacinamide 1.2% and preservative 0.3%.
Preferably, the NMF be xylitol glucoside, anhydro xylitol and xylitol mixture, the matter of three Amount ratio is (0.3~3) (0.5~4):1.
Preferably, the preservative is at least one in Phenoxyethanol, methyl hydroxybenzoate, ethyl hydroxy benzoate and Xanthan Gum Kind.
Wherein, glycerine have the function that skin care, prevent it is dry and cracked.Xanthan Gum, it has low concentration highly viscous Characteristic (100 times of the viscosity of 1% aqueous solution equivalent to gelatin), is a kind of efficient thickener;And it is to insoluble solid There is good suspension effect with oil droplet.Xanthan Gum molecule can form the spiral EVA of superjunction crossed belt shape, form fragile Similar glue network structure, so the form of solid particle, drop and bubble can be supported, show very strong stable emulsifying Act on and uphang i.In addition, it can quickly dissolve in water, there is good water solubility.It can also be dissolved especially in cold water, Numerous and diverse process can be saved, it is easy to use.
EGF stostes are epithelical cell growth factor, also known as people oligopeptides -1, are a kind of active materials in human body, by 53 The active peptides of amino composition, by the tyrosine phosphorylation for stimulating EGFR, reach repairing hyperplasia flesh Skin cells of superficial layer, excellent curative effect is possessed to injured, impaired epidermis skin.Its maximum feature is can to promote the propagation of cell Differentiation, so as to replace aging and dead cell with the cell of new life.EGF can also stop blooding, and with acceleration skin and mucous membrane wound Recover from injury and close, anti-inflammatory analgesic, the effect of preventing ulcer.EGF stability is fabulous, is not easy flowing of scattering, energy and people at normal temperatures Internal various enzymes form good coordinating effect.Initial EGF is mainly employed for medical domain, is primarily to facilitate defect table The reparation and regeneration of skin, such as treatment burn, scald.
EGF can promote the growth of various kinds of cell in epidermal cell tissue to divide, and epidermal cell is become full, recover young State, it can also promote collagen growth ability, the collagen elastomer of aging fracture be repaired, so by numerous scientists It is described as " the beautiful factor ".But EGF early stage yield is few, nearly 2,000,000 dollars of every gram of price, EGF is greatly limit in beauty The application in field.1992, EGF was added in cosmetics by U.S. James's drug study room, started beautiful with EGF biology Hold frontier, indicate the arrival in biological gene beauty epoch.
EGF can promote human body skin quickly to update, it is well known that and woman's age is smaller, and skin is better, more pale tender and lovely, Its root original is exactly that the age is smaller, and EGF contents are higher in skin, and skin renewal speed is faster, such skin with regard to tender and lovely, but with The increase at age, EGF content also progressively declines in skin, after 25 years old, declines faster, and such skin is with regard to aging, coarse, heavy Shallow lake color spot, therefore EGF content, determine whether skin is tender and lovely, so EGF is also referred to as the beautiful factor by people.
Oat polypeptide is formed by enzymolysis process of the high-quality avenin through uniqueness is refined, is had the property that:1. oat is more Peptide extracts from high mountain oat, has excellent performance of keeping humidity, fast skin penetration and withered hair can be dried, in skin and hair surface Form protective layer.2. oat polypeptide, which has, suppresses MMP-1 activity, increase the content of collagen in skin, strengthen skin elasticity. 3. oat polypeptide is small molecule bioactive peptide, accelerates cell propagation and metabolism, Cucumber Extract, reduce skin roughness, Resistance free radical makes skin shine delicate and charming elegance.4. it is safe to use, conveniently, it can be directly added into cosmetic formulations.Can effectively it hinder Break to the great chain reaction of skin damage, so as to safeguard that skin structure matter is complete, suppress thinning of skin, strengthen skin elasticity. Available for enhancing skin elasticity skin-protection product and film forming hair products.Anti-aging product.Promote cell propagation product.It is long-acting, high Imitate moisture retention product.
Tocopherol acetate is vitamin E, and it is a kind of liposoluble vitamin, is one of most important antioxidant.Dimension Raw plain E can effectively antagonize free radical, suppress lipid peroxide generation, eliminating chloasma;Suppress the activity of tyrosinase, so as to subtract Few melanin generation.The vitamin E of esterified form can also eliminate as caused by the extraneous factors such as ultraviolet, air pollution excessive Oxygen radical, play and delay the effects such as light aging, prevention sunburn and suppression sunburn generation.
Glycine betaine stoste is a kind of alkaloid, has strong moisture pick-up properties, so often being used in manufacture craft Anti-caking agent processing, its molecular structure, application effect, without significant difference, belong to natural goods of chemical synthesis etc. with natural glycine betaine Jljl.
Panthenol, i.e. vitamin B5, it is a kind of NMF and softening agent, oxidizable, can promote the normal angling of skin, is promoted Enter wound healing and skin histology reparation, stimulate cell division to regenerate, to promoting scar healing highly effective.Acrylic acid hydroxyl second Ester-sodium acryloyldimethyl taurate copolymers then use as thickener.
Contain polyphenolic substance in Carlina acaulis extract, these polyphenolic substances have stronger oxidisability, so as to have The effect of anti-aging, and chlorogenic acid, cynarin, Luteolin -7- rutinosides and cynara scolymus sugar in Carlina acaulis extract Glycosides has higher antimicrobial, antimycotic and antibacterial activity;Leonurus extract has beneficial face beauty, the work(of anti-aging Effect.
Saualane has preferable compatibility to skin, moisten and non-greasy, moisture retention are strong, have it is crease-resistant the effect of, and And the peroxidating of skin lipid can be suppressed, and skin is effectively penetrated, promotes the propagation of skin base cell, it is old to delaying skin Change, improving and eliminating chloasma has obvious physiologic effect.And it can also open the pore of skin, promote that blood is micro- follows Ring, promotes the metabolism of cell, and damaged cell is repaired in help;It can also strengthen repairing epidermis, be effectively formed natural diaphragm, The balance between skin and sebum is helped, allergy and stimulation will not be caused, and can accelerate in being formulated other active components into skin Infiltration, pure, colourless, free from extraneous odour.
Niacinamide is nicotinic acid, is a kind of water soluble vitamin, and it can mitigate and prevent skin in early stage aging course In the caused colour of skin is dull, jaundice, famished look.Niacinamide can also repair impaired Stratum corneum lipids barrier, improve skin resistance Power.Niacinamide also has deep layer water lock effect, so, the skin care item containing niacinamide are to having extremely strong water lock, moisture-keeping efficacy.
Embodiment described above only expresses the embodiment of the present invention, and its description is more specific and detailed, but simultaneously Therefore the limitation to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that for one of ordinary skill in the art For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention Protect scope.

Claims (5)

1. a kind of anti-ageing gold goal frost, it is characterised in that by mass percentage, it includes following components:Glycerine 5%~9%, it is yellow Unit cell polysaccharide 1.5%~9% and deionized water 50%~75%, EGF stostes 1.1%~2.8%, oat polypeptide 1.2%~ 2.8%, glycine betaine stoste 1.0%~3.0%, panthenol 0.05%~0.5%, aloe essential oil 0.01%~0.15% and tocopherol Acetic acid esters 0.5%~3.0%, NMF 1.0%~3.0%, Carlina acaulis extract 1.0%~3.0%, Leonurus extract 1.0%~3.0%, saualane 1.0%~10%, niacinamide 0.5%~2.0% and preservative 0.1%~0.6%.
2. anti-ageing gold goal frost according to claim 1, it is characterised in that by mass percentage, it includes following components: Glycerine 6%~8%, Xanthan Gum 2%~8% and deionized water 60%~70%, EGF stostes 1.2%~2.0%, oat Polypeptide 1.2%~2.0%, glycine betaine stoste 1.5%~2.5%, panthenol 0.1%~0.3%, the He of essential oil 0.05%~0.12% Tocopherol acetate 0.7%~1.5%, NMF 1.5%~2.5%, Carlina acaulis extract 1.5%~2.5%, motherwort carries Take thing 1.5%~2.5%, saualane 2%~8%, niacinamide 0.7%~1.5% and preservative 0.2%~0.5%.
3. anti-ageing gold goal frost according to claim 2, it is characterised in that by mass percentage, it includes following components: Glycerine 7%, Xanthan Gum 3.2% and deionized water 59.3%, EGF stostes 1.5%, oat polypeptide 15%, glycine betaine stoste 2.0%, panthenol 0.2%, essential oil 0.10% and tocopherol acetate 1.0%, NMF 2.0%, Carlina acaulis extract 2.0%, Leonurus extract 2.0%, saualane 3.2%, niacinamide 1.2% and preservative 0.3%.
4. the anti-ageing gold goal frost according to any one of claims 1 to 3, it is characterised in that the NMF is xylitol Portugal The mixture of polyglycoside, anhydro xylitol and xylitol, the mass ratio of three is (0.3~3) (0.5~4):1.
5. according to any one of claims 1 to 3 anti-ageing gold goal frost, it is characterised in that the preservative be Phenoxyethanol, At least one of methyl hydroxybenzoate, ethyl hydroxy benzoate and Xanthan Gum.
CN201710671443.7A 2017-08-08 2017-08-08 A kind of anti-ageing gold goal frost Pending CN107510627A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104352385A (en) * 2014-10-20 2015-02-18 东莞市阿比亚能源科技有限公司 Anti-ageing essence
CN104352418A (en) * 2014-10-20 2015-02-18 东莞市阿比亚能源科技有限公司 Anti-ageing essence

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104352385A (en) * 2014-10-20 2015-02-18 东莞市阿比亚能源科技有限公司 Anti-ageing essence
CN104352418A (en) * 2014-10-20 2015-02-18 东莞市阿比亚能源科技有限公司 Anti-ageing essence

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
刘利萍等: "《实用美容药物常识》", 30 September 2013, 重庆大学出版社 *
王昌涛等: "《化妆品植物学》", 31 July 2009, 中国农业大学出版社 *

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RJ01 Rejection of invention patent application after publication

Application publication date: 20171226

RJ01 Rejection of invention patent application after publication