CN107501258B8 - 一种噻唑基烟酰胺类化合物及其在制备抗过敏和哮喘药物中的应用 - Google Patents

一种噻唑基烟酰胺类化合物及其在制备抗过敏和哮喘药物中的应用 Download PDF

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Publication number
CN107501258B8
CN107501258B8 CN201710828917.4A CN201710828917A CN107501258B8 CN 107501258 B8 CN107501258 B8 CN 107501258B8 CN 201710828917 A CN201710828917 A CN 201710828917A CN 107501258 B8 CN107501258 B8 CN 107501258B8
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China
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thiazolyl
preparing
antiallergy
asthmatic medicament
medicament
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CN201710828917.4A
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CN107501258B (zh
CN107501258A (zh
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董泽华
刘双伟
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Affiliated Hospital of University of Qingdao
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Affiliated Hospital of University of Qingdao
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Priority to CN201810421668.1A priority patent/CN108299418A/zh
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Publication of CN107501258B publication Critical patent/CN107501258B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

本发明公开了一种噻唑基烟酰胺类化合物式（Ⅰ）及其在制备抗过敏和哮喘药物中的应用，，其中，R1选自H、F或Cl，R2选自H或Cl，R3选自H或Cl。本发明所述的噻唑基烟酰胺类化合物式（Ⅰ）为全新的骨架类型的组胺受体拮抗剂，属于首次公开，毒副作用低，可以用于抗组胺药物、抗过敏性疾病药物、哮喘药物的深入研究与开发，在制备治疗过敏和哮喘药物中具有很好的应用前景。
CN201710828917.4A 2017-09-14 2017-09-14 一种噻唑基烟酰胺类化合物及其在制备抗过敏和哮喘药物中的应用 Expired - Fee Related CN107501258B8 (zh)

Priority Applications (2)

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CN201710828917.4A CN107501258B8 (zh) 2017-09-14 2017-09-14 一种噻唑基烟酰胺类化合物及其在制备抗过敏和哮喘药物中的应用
CN201810421668.1A CN108299418A (zh) 2017-09-14 2017-09-14 一种抗过敏和哮喘的噻唑基烟酰胺类化合物的合成方法

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CN201710828917.4A CN107501258B8 (zh) 2017-09-14 2017-09-14 一种噻唑基烟酰胺类化合物及其在制备抗过敏和哮喘药物中的应用

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CN107501258A CN107501258A (zh) 2017-12-22
CN107501258B CN107501258B (zh) 2018-08-28
CN107501258B8 true CN107501258B8 (zh) 2018-10-16

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CN201710828917.4A Expired - Fee Related CN107501258B8 (zh) 2017-09-14 2017-09-14 一种噻唑基烟酰胺类化合物及其在制备抗过敏和哮喘药物中的应用

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1527830A (zh) * 2001-01-31 2004-09-08 �Ʒ� 用作pde4同工酶的抑制剂的醚衍生物
CN1914205A (zh) * 2003-12-19 2007-02-14 葛兰素集团有限公司 吡唑并[3,4－b]吡啶化合物及其作为磷酸二酯酶抑制剂的用途
WO2010056875A1 (en) * 2008-11-12 2010-05-20 Cgi Pharmaceuticals, Inc. Pyridazinones and their use as btk inhibitors
WO2013063385A1 (en) * 2011-10-28 2013-05-02 Synta Pharmaceuticals Corp. Compounds for inflammation and immune-related uses
TWI444370B (zh) * 2006-01-25 2014-07-11 Synta Pharmaceuticals Corp 用於發炎及免疫相關用途之噻唑及噻二唑化合物
CN106905311A (zh) * 2010-08-27 2017-06-30 钙医学公司 调节细胞内钙的化合物

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1527830A (zh) * 2001-01-31 2004-09-08 �Ʒ� 用作pde4同工酶的抑制剂的醚衍生物
CN1914205A (zh) * 2003-12-19 2007-02-14 葛兰素集团有限公司 吡唑并[3,4－b]吡啶化合物及其作为磷酸二酯酶抑制剂的用途
TWI444370B (zh) * 2006-01-25 2014-07-11 Synta Pharmaceuticals Corp 用於發炎及免疫相關用途之噻唑及噻二唑化合物
WO2010056875A1 (en) * 2008-11-12 2010-05-20 Cgi Pharmaceuticals, Inc. Pyridazinones and their use as btk inhibitors
CN106905311A (zh) * 2010-08-27 2017-06-30 钙医学公司 调节细胞内钙的化合物
WO2013063385A1 (en) * 2011-10-28 2013-05-02 Synta Pharmaceuticals Corp. Compounds for inflammation and immune-related uses

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CN108299418A (zh) 2018-07-20
CN107501258B (zh) 2018-08-28
CN107501258A (zh) 2017-12-22

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Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB03 Change of inventor or designer information

Inventor after: Dong Zehua

Inventor after: Liu Shuangwei

Inventor before: Liu Shuangwei

CB03 Change of inventor or designer information
GR01 Patent grant
GR01 Patent grant
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20180828

Address after: 266071 16 Jiangsu Road, Shinan District, Qingdao, Shandong

Patentee after: THE AFFILIATED HOSPITAL OF QINGDAO University

Address before: 262610 Yueyang Zhuang medicine research base, Xin Zhai Town, Linqu County, Weifang, Shandong

Patentee before: Liu Shuangwei

CI03 Correction of invention patent
CI03 Correction of invention patent

Correction item: Patentee|Address|Inventor|Patent agency|Agent

Correct: Affiliated Hospital of University Of Qingdao|266071 16 Jiangsu Road, Shinan District, Qingdao, Shandong|Dong Zehua, Liu Shuangwei|Qingdao Hua Hui patent agency (general partnership) 37247|Qu Xianrong, Ma Qian Hui

False: Liu Shuangwei|262610 Yueyang Zhuang medicine research base, Xin Zhai Town, Linqu County, Weifang, Shandong|Liu Shuangwei|N/A

Number: 35-01

Volume: 34

Correction item: Patentee|Address|Inventor|Patent agency|Agent

Correct: Affiliated Hospital of University Of Qingdao|266071 16 Jiangsu Road, Shinan District, Qingdao, Shandong|Dong Zehua, Liu Shuangwei|Qingdao Hua Hui patent agency (general partnership) 37247, Qu Xianrong, Ma Qian Hui

False: Liu Shuangwei|262610 Yueyang Zhuang medicine research base, Xin Zhai Town, Linqu County, Weifang, Shandong|Liu Shuangwei|N/A

Number: 35-01

Page: The title page

Volume: 34

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20180828

Termination date: 20210914

CF01 Termination of patent right due to non-payment of annual fee