CN107495968A - The device with anaesthetizing is fixed for mouse magnetic resonance - Google Patents
The device with anaesthetizing is fixed for mouse magnetic resonance Download PDFInfo
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- CN107495968A CN107495968A CN201710787740.8A CN201710787740A CN107495968A CN 107495968 A CN107495968 A CN 107495968A CN 201710787740 A CN201710787740 A CN 201710787740A CN 107495968 A CN107495968 A CN 107495968A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
- A61D2003/003—Appliances for supporting or fettering animals for operative purposes with head or neck restraining means
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
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- Biophysics (AREA)
- High Energy & Nuclear Physics (AREA)
- Radiology & Medical Imaging (AREA)
- Anesthesiology (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Husbandry (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
The present invention provides a kind of device fixed for mouse magnetic resonance with anaesthetizing, and belongs to technical field of medical instruments.Postanesthetic mouse is placed in mouse place position during use, mouse is fixed by solid mouth device and solid ear device, in magnetic resonance examination experimentation, persistently lead to the oxygen of low discharge to mouse by oxygen catheter, prevent that mouse is dead in resonance examination procedure, when being revived such as mouse, in the case where not changing mouse position, swivel tee pipe, anesthetic is conveyed by anesthetic conduit in real time, realize to the real-time anesthesia of mouse, both realized and the long-time of mouse had been fixed, it turn avoid the problem of disposable excessive anesthetic causes dead mouse, and fix the apparatus structure compact and reasonable with anaesthetizing for mouse magnetic resonance, realize and the matching of experiment magnetic resonance examination coil, improve magnetic resonance examination experiment success rate.
Description
Technical field
The present invention relates to technical field of medical instruments, specially a kind of device fixed for mouse magnetic resonance with anaesthetizing.
Background technology
Science and technology continuous progress with rapid changepl. never-ending changes and improvements, along with being on the increase for medical inspection means, magnetic resonance is increasingly
More is applied in clinical examination and experimental study, but in existing many achievements in research, still can not solve and answer and be big
The mechanism that Partial tumors venereal disease becomes, but people increasingly thirst for these problems obtaining answer, therefore researcher is not
It is disconnected to be desirable to find answer with the experimental animals such as mouse, so as to capture the tumor disease for endangering human health.Research
Personnel are planted in the animal bodies such as mouse and marked tumor cell, it is desirable to by the advanced inspection equipment such as magnetic resonance, understand small
Variation Features of the tumour cell in cellular elements level are labeled in mouse body, so as to disclose the generation of neoplastic lesion and development
Mechanism.
In mouse magnetic resonance examination is carried out, under certain magnetic field intensity, sweep time length determines the contrast of image,
During especially mouse magnetic resonance examination experimental study checks, scanning sequence is more, and the time is longer, general more more than half an hour.
The fixing device that prior art provides can not long-time stable fixation mouse, in order to prevent dead mouse not in checking process
The energy substantial amounts of anesthetic of first use, in addition, the coil requirement that magnetic resonance examination is special, common mouse fix experiment porch because of body
Product is larger and can not match with experiment magnetic resonance examination coil, the higher scan image of resolution ratio can not be obtained, to understand
Certainly above mentioned problem needs a kind of device fixed for mouse magnetic resonance with anaesthetizing badly.
The content of the invention
For problems of the prior art, the present invention provides a kind of dress fixed for mouse magnetic resonance with anaesthetizing
Put, fixed mouse can be stablized, and persistent low flow oxygen supply is carried out to mouse, such as mouse revival in magnetic resonance examination experiment,
Mouse can be anaesthetized in real time in the case where not changing mouse position, so as to which favourable ensure that magnetic resonance examination reality
Test success rate.
The present invention is to be achieved through the following technical solutions：
The device with anaesthetizing is fixed for mouse magnetic resonance, including：Mounting platform, solid ear device, solid mouth device, upper end
Lid, anesthetic conduit and oxygen catheter；
Mouse place position is provided with one end of the mounting platform, Gu ear device is located at both sides and the peace of mouse place position
Assembling platform connects, Gu ear device is used to fix mouse by the earhole of mouse；
The solid mouth device is located at one end of end of the mouse place position away from mounting platform, is connected with mounting platform, Gu
Mouth device is used to fix mouse by mouse oral area；
The top that the upper end cover is located at solid mouth device connects with mounting platform, and upper end cover is close to one end of mouse place position
Solid mouth gap is provided with, the other end is connected by triple valve with anesthetic conduit and oxygen catheter.
Optionally, the solid ear device includes：Gu ear rod, solid ear sliding block and support frame；
Support frame as described above connects with mounting platform, Gu ear sliding block and support frame are slidably connected, Gu ear sliding block can support
Vertically slided on frame；
The solid ear rod and solid ear sliding block are slidably connected, Gu ear rod can slide in the horizontal direction on solid ear sliding block, Gu
One end of ear rod is provided with top, and solid the top of ear rod on the solid ear device of mouse place position both sides is oppositely arranged.
Optionally, it is provided with adjusting screw on support frame as described above and solid ear sliding block.
Optionally, the solid mouth device includes：Top board, lower platen, solid mouth sliding block and solid mouth mounting blocks；
The solid mouth mounting blocks connect with mounting platform, Gu mouth sliding block and solid mouth mounting blocks are slidably connected, Gu mouth sliding block exists
Gu it can be slided on mouth mounting blocks along mounting platform length direction；
One end of the solid mouth sliding block is provided with chute, and one end of lower platen is arranged in the chute, and lower platen is in cunning
Can vertically it be slided in groove, the top that top board is located at lower platen connects with lower platen.
Optionally, the top board and lower platen are bolted, and spring is provided between top board and lower platen.
Optionally in described consolidate on mouth mounting blocks and solid mouth sliding block is provided with adjusting screw.
Optionally, mounting platform, solid ear device, solid mouth device, upper end cover, anesthetic conduit and oxygen catheter are using modeling
Material, resin, rubber, aluminium alloy or titanium alloy material are made.
Compared with prior art, the present invention has technique effect beneficial below：
The device with anaesthetizing is fixed provided by the present invention for mouse magnetic resonance, is placed in postanesthetic mouse during use small
In mouse place position, mouse is fixed by solid mouth device and solid ear device, in resonance examination procedure, continued by oxygen catheter
Mouse into anesthesia leads to the oxygen of low discharge, prevents that mouse is dead in magnetic resonance examination experimentation, magnetic resonance examination mistake
Cheng Zhong, such as mouse revival, in the case where not changing position, swivel tee pipe, anesthesia is conveyed by anesthetic conduit in real time
Agent, realize to the real-time anesthesia of mouse, both realized and the long-time of mouse is fixed, turn avoid disposable excessive anesthetic
The problem of causing dead mouse, and the apparatus structure compact and reasonable with anaesthetizing is fixed for mouse magnetic resonance, realize and real
The matching with magnetic resonance examination coil is tested, improves magnetic resonance examination experiment success rate.
Further, the solid ear sliding block being slidably connected with support frame and the solid ear being slidably connected with solid ear sliding block are passed through
Rod, the adjustable of solid ear device is realized, adds the adaptability of solid ear device, solid ear device is directed to different mouse
Use.
Further, it is slidably connected down by the solid mouth sliding block that is slidably connected with solid mouth mounting blocks and with solid mouth sliding block
Pressing plate, the adjustable of solid mouth device is realized, adds the adaptability of solid mouth device, enable solid mouth device for different
Mouse uses；
Further, because mounting platform, solid ear device, solid mouth device, upper end cover, anesthetic conduit and oxygen catheter are equal
It is made of plastics, resin or rubber, aluminium alloy or titanium alloy etc materials, avoids the shadow to magnetic field containing ferromagnetic material
Ring.
Brief description of the drawings
Fig. 1 is a kind of structural representation that the device with anaesthetizing is fixed for mouse magnetic resonance provided in an embodiment of the present invention
Figure；
Fig. 2 is a kind of sectional view that the device with anaesthetizing is fixed for mouse magnetic resonance provided in an embodiment of the present invention；
Fig. 3 is a kind of structural representation of solid ear device provided in an embodiment of the present invention；
Fig. 4 is a kind of structural representation of solid mouth device provided in an embodiment of the present invention.
In figure：1. mounting platform, 2. solid ear devices, 3. solid mouthful devices, 4. upper end covers, 5. anesthetic conduits, 6. oxygen are led
Pipe；
21. support frame, 22. solid ear sliding blocks, 23. solid ear rods, 31. solid mouthful mounting blocks, 32. solid mouthful sliding blocks, 33. top boards,
34. lower platen.
Embodiment
With reference to specific embodiment, the present invention is described in further detail, it is described be explanation of the invention and
It is not to limit.
Fig. 1 is the schematic diagram provided in an embodiment of the present invention that the device with anaesthetizing is fixed for mouse magnetic resonance, such as Fig. 1 institutes
Show, the device with anaesthetizing is fixed for mouse magnetic resonance, including：Mounting platform 1, solid ear device 2, solid mouth device 3, upper end cover 4
With anesthetic conduit 5；Mouse place position is provided with one end of mounting platform 1, Gu ear device 2 is located at the both sides of mouse place position
Connected with mounting platform 1, Gu ear device 2 is used to fix mouse by the earhole of mouse；It is remote that Gu mouth device 3 is located at mouse place position
Connected from one end of the end of mounting platform 1, and mounting platform 1, Gu mouth device 3 is used to fix mouse by mouse oral area；On
End cap 4 is located at the top of solid mouth device 3 and mounting platform 1 connects, and upper end cover 4 is provided with Gu Kou close to one end of mouse place position
Gap, the other end are connected by triple valve and anesthetic conduit 5 and oxygen catheter 6.
Wherein, upper end cover 4 and mounting platform 1, in fixed mouse, can remove upper end cover 4 to be detachably connected, will
After the completion of mouse is fixed, upper end cover 4 is arranged on installation site, such as, upper end cover 4 and mounting platform 1 can be mode connects for screw
Either snap connection.Because magnetic resonance examination experimental period is longer, postanesthetic mouse was easily tested in magnetic resonance examination
It is dead in journey, in order to avoid dead mouse, low discharge oxygen can be continually fed into by oxygen catheter 6, ensures mouse survival rate,
Magnetic resonance examination experiment success rate is improved, in case of mouse revives in resonance examination procedure, is not changing the feelings of mouse position
Under condition, switching three-way valve, by anesthetic conduit 5, anesthetic is passed through in real time, mouse is anaesthetized again.
Fig. 3 is the schematic diagram of solid ear device 2 provided in an embodiment of the present invention, as shown in Fig. 2 solid ear device 2 includes：Gu ear
Rod 23, solid ear sliding block 22 and support frame 21；Support frame 21 and mounting platform 1 connect, Gu ear sliding block 22 and support frame 21 are slided and connected
Connect, Gu ear sliding block 22 can vertically slide on support frame 21；Gu ear rod 23 and solid ear sliding block 22 are slidably connected, Gu ear
Rod 23 can slide in the horizontal direction on solid ear sliding block 22, Gu one end of ear rod 23 be provided with it is top, positioned at mouse place position
Solid the top of ear rod 23 on the solid ear device 2 of both sides is oppositely arranged.
Wherein, support frame 21 and mounting platform 1 are vertically arranged, and its connected mode can be threaded connection, Gu ear sliding block 22
Being enclosed on support frame 21 can slide along support frame 21, adjust the height of solid ear sliding block 22, make the solid height of ear rod 23 and mouse ear
Hole is highly identical, is now fixed solid ear sliding block 22 by adjusting screw；Solid ear 23 stretching in solid ear sliding block 22 of rod of adjustment
Amount, to ensure that the solid ear rod 23 of both sides stretches into the earhole of mouse, the position of solid ear rod 23 is fixed by adjusting screw.
Fig. 4 is the schematic diagram of solid mouth device 3 provided in an embodiment of the present invention, as shown in figure 3, solid mouth device 3 includes：Upper pressure
Plate 33, lower platen 34, solid mouth sliding block 32 and solid mouth mounting blocks 31；Gu mouth mounting blocks 31 and mounting platform 1 connect, Gu mouth sliding block 32
It is slidably connected with solid mouth mounting blocks 31, Gu mouth sliding block 32 can slide on solid mouth mounting blocks 31 along the length direction of mounting platform 1；
Gu one end of mouth sliding block 32 is provided with chute, one end of lower platen 34 is arranged in the chute, the energy in chute of lower platen 34
Enough vertically to slide, top board 33 is located at the top of lower platen 34 and lower platen 34 connects.
Wherein, during fixed mouse mouth position, slide solid mouth sliding block 32 adjust top board 33 and mouse oral area it is horizontal away from
From, the vertical distance that top board 33 adjusts top board 33 and mouse oral area is slided, it is solid by adjusting screw fixation after being adjusted in place
The position of mouth sliding block 32 and lower platen 34, is compressed top board 33 and lower platen 34 by bolt, fixed mouse oral area.Top board
Spring is installed between 33 and lower platen 34, in order to which top board 33 and lower platen 34 reset.
The special magnetic field environment of magnetic resonance, do not allow containing the particular/special requirements such as ferromagnetic object entrance, therefore, mounting platform
1st, solid ear device 2, solid mouth device 3, upper end cover 4, anesthetic conduit 5 and oxygen catheter 6 are closed using plastics, resin, rubber, aluminium
Gold or titanium alloy etc materials are made.
A kind of use process of device for being used to fix and anaesthetize for mouse magnetic resonance provided in an embodiment of the present invention has
Body is as follows：
Mouse will be placed in after mouse anesthesia and places bin location, mouse mouth position is fixed by solid mouth device 3, passes through solid ear
Device 2 fixes mouse ear；
Upper end cover 4 is covered, by being continually fed into low discharge oxygen in oxygen catheter 6 upwards lid；
If mouse revives in magnetic resonance examination experimentation, switching three-way valve, in the case where not changing mouse position,
Anesthetic anesthetized mice is passed through by anesthetic conduit 5.
Optionally, mouse mouth position is fixed by solid mouth device 3, fixing mouse ear by solid ear device 2 includes：
By sliding solid mouth sliding block 32 and lower platen 34, the position of lower platen 34 is adjusted, passes through top board 33 and lower platen
34 fix mouse mouth position；
By sliding solid ear sliding block 22 and solid ear rod 23, the position of solid ear rod 23 is adjusted, by being arranged on mouse place position
The solid ear rod 23 of both sides fixes mouse ear position.
Wherein, Gu ear sliding block 22 is enclosed on support frame 21 to be slided along support frame 21, the height of solid ear sliding block 22 is adjusted,
Make the solid height of ear rod 23 and mouse earhole highly identical, now fixed solid ear sliding block 22 by adjusting screw；The solid ear rod of adjustment
23 overhang in solid ear sliding block 22, to ensure that the solid ear rod 23 of both sides stretches into the earhole of mouse, fixed by adjusting screw
Gu the position of ear rod 23.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent substitution and improvements made etc., it should be included in the scope of the protection.
Claims (7)
1. fix the device with anaesthetizing for mouse magnetic resonance, it is characterised in that including：Mounting platform (1), admittedly ear device (2),
Gu mouth device (3), upper end cover (4), anesthetic conduit (5) and oxygen catheter (6)；
Be provided with mouse place position on one end of the mounting platform (1), Gu ear device (2) be located at mouse place position both sides and
Mounting platform (1) connects, Gu ear device (2) is used to fix mouse by the earhole of mouse；
The solid mouth device (3) is located at one end of end of the mouse place position away from mounting platform (1), and mounting platform (1) is even
Connect, Gu mouth device (3) is used to fix mouse by mouse oral area；
The upper end cover (4) is located at the top of solid mouth device (3) and mounting platform (1) connection, upper end cover (4) are placed close to mouse
The one end in storehouse is provided with solid mouth gap, and the other end is connected by triple valve and anesthetic conduit (5) and oxygen catheter (6).
2. fix the device with anaesthetizing for mouse magnetic resonance as claimed in claim 1, it is characterised in that the solid ear device
(2) include：Gu ear rod (23), solid ear sliding block (22) and support frame (21)；
Support frame as described above (21) and mounting platform (1) connection, Gu ear sliding block (22) and support frame (21) are slidably connected, Gu ear sliding block
(22) can vertically be slided on support frame (21)；
The solid ear rod (23) and solid ear sliding block (22) are slidably connected, Gu ear rod (23) can be on solid ear sliding block (22) along level
Direction is slided, Gu one end of ear rod (23) is provided with top, the solid ear rod on the solid ear device (2) of mouse place position both sides
(23) top is oppositely arranged.
3. fix the device with anaesthetizing for mouse magnetic resonance as claimed in claim 2, it is characterised in that support frame as described above
(21) and on solid ear sliding block (22) it is provided with adjusting screw.
4. fix the device with anaesthetizing for mouse magnetic resonance as claimed in claim 1, it is characterised in that the solid mouth device
(3) include：Top board (33), lower platen (34), solid mouth sliding block (32) and solid mouth mounting blocks (31)；
The solid mouth mounting blocks (31) and mounting platform (1) connection, Gu mouth sliding block (32) and solid mouth mounting blocks (31) are slidably connected,
Gu mouth sliding block (32) can slide on solid mouth mounting blocks (31) along mounting platform (1) length direction；
One end of the solid mouth sliding block (32) is provided with chute, and one end of lower platen (34) is arranged in the chute, lower platen
(34) can vertically be slided in chute, top board (33) is located at the top of lower platen (34) and lower platen (34) connects
Connect.
5. fix the device with anaesthetizing for mouse magnetic resonance as claimed in claim 4, it is characterised in that the top board
(33) it is bolted with lower platen (34), spring is provided between top board (33) and lower platen (34).
6. fix the device with anaesthetizing for mouse magnetic resonance as claimed in claim 4, it is characterised in that the Gu Kou installations
Adjusting screw is provided with block (31) and solid mouth sliding block (32).
7. the device for being used for mouse magnetic resonance and fixing and anaesthetizing as described in claim 1 to 6 is any, it is characterised in that installation
Platform (1), solid ear device (2), solid mouth device (3), upper end cover (4), anesthetic conduit (5) and oxygen catheter (6) are using modeling
Material, resin, rubber, aluminium alloy or titanium alloy material are made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710787740.8A CN107495968A (en) | 2017-09-04 | 2017-09-04 | The device with anaesthetizing is fixed for mouse magnetic resonance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710787740.8A CN107495968A (en) | 2017-09-04 | 2017-09-04 | The device with anaesthetizing is fixed for mouse magnetic resonance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107495968A true CN107495968A (en) | 2017-12-22 |
Family
ID=60695841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710787740.8A Pending CN107495968A (en) | 2017-09-04 | 2017-09-04 | The device with anaesthetizing is fixed for mouse magnetic resonance |
Country Status (1)
| Country | Link |
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| CN (1) | CN107495968A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110200724A (en) * | 2019-07-03 | 2019-09-06 | 武汉瑞福宁科技有限公司 | A kind of rats and mice gas anesthesia mask |
| CN110638452A (en) * | 2019-09-17 | 2020-01-03 | 哈尔滨医科大学 | Small animal nuclear magnetic resonance scanning, fixing and anaesthesia integrated device and using method |
| CN110786853A (en) * | 2018-08-03 | 2020-02-14 | 中国科学院上海生命科学研究院 | Mouse head fixing device for magnetic resonance imaging and fixing method thereof |
| CN110974283A (en) * | 2019-12-20 | 2020-04-10 | 中南大学湘雅二医院 | Fixator for measuring rat by bone densitometer by dual-energy X-ray absorption method and manufacturing method |
| CN113100744A (en) * | 2021-03-29 | 2021-07-13 | 华中科技大学同济医学院附属协和医院 | Positioning device for animal nuclear magnetic resonance imaging |
| CN114699204A (en) * | 2021-11-17 | 2022-07-05 | 武汉联影生命科学仪器有限公司 | Animal experiment operation platform and magnetic resonance imaging laboratory |
-
2017
- 2017-09-04 CN CN201710787740.8A patent/CN107495968A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110786853A (en) * | 2018-08-03 | 2020-02-14 | 中国科学院上海生命科学研究院 | Mouse head fixing device for magnetic resonance imaging and fixing method thereof |
| CN110786853B (en) * | 2018-08-03 | 2024-02-23 | 中国科学院脑科学与智能技术卓越创新中心 | Mouse head fixing device for magnetic resonance imaging and fixing method thereof |
| CN110200724A (en) * | 2019-07-03 | 2019-09-06 | 武汉瑞福宁科技有限公司 | A kind of rats and mice gas anesthesia mask |
| CN110638452A (en) * | 2019-09-17 | 2020-01-03 | 哈尔滨医科大学 | Small animal nuclear magnetic resonance scanning, fixing and anaesthesia integrated device and using method |
| CN110974283A (en) * | 2019-12-20 | 2020-04-10 | 中南大学湘雅二医院 | Fixator for measuring rat by bone densitometer by dual-energy X-ray absorption method and manufacturing method |
| CN113100744A (en) * | 2021-03-29 | 2021-07-13 | 华中科技大学同济医学院附属协和医院 | Positioning device for animal nuclear magnetic resonance imaging |
| CN114699204A (en) * | 2021-11-17 | 2022-07-05 | 武汉联影生命科学仪器有限公司 | Animal experiment operation platform and magnetic resonance imaging laboratory |
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