CN107495362A - A kind of Diabetic Nephropathy patients nutriment - Google Patents

A kind of Diabetic Nephropathy patients nutriment Download PDF

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Publication number
CN107495362A
CN107495362A CN201710649713.4A CN201710649713A CN107495362A CN 107495362 A CN107495362 A CN 107495362A CN 201710649713 A CN201710649713 A CN 201710649713A CN 107495362 A CN107495362 A CN 107495362A
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CN
China
Prior art keywords
diabetic nephropathy
nutriment
prebiotics
fruit
probiotics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710649713.4A
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Chinese (zh)
Inventor
岳朋
周锦源
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Ling Zhi Medical Science And Technology Co Ltd
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Shenzhen Ling Zhi Medical Science And Technology Co Ltd
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Filing date
Publication date
Application filed by Shenzhen Ling Zhi Medical Science And Technology Co Ltd filed Critical Shenzhen Ling Zhi Medical Science And Technology Co Ltd
Priority to CN201710649713.4A priority Critical patent/CN107495362A/en
Priority to PCT/CN2017/105663 priority patent/WO2019024248A1/en
Publication of CN107495362A publication Critical patent/CN107495362A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135Bacteria or derivatives thereof, e.g. probiotics
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21Addition of substantially indigestible substances, e.g. dietary fibres
    • A23L33/22Comminuted fibrous parts of plants, e.g. bagasse or pulp
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21Addition of substantially indigestible substances, e.g. dietary fibres
    • A23L33/25Synthetic polymers, e.g. vinylic or acrylic polymers
    • A23L33/26Polyol polyesters, e.g. sucrose polyesters; Synthetic sugar polymers, e.g. polydextrose
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The present invention relates to a kind of Diabetic Nephropathy patients nutriment, including following components:Fruit-vegetable fibre, prebiotics, oat beta-glucan and probiotics.Because fruit-vegetable fibre, prebiotics, oat beta-glucan and probiotics regulation human body intestinal canal flora balance can target " insulin resistance path " by fat metabolism approach, improve the high fat of blood in diabetic nephropathy source and the symptom of hyperglycaemia;Suppress urotoxic generation by targetting " inflammation urotoxin path " simultaneously, so as to play protection renal, prevent the effect that sb.'s illness took a turn for the worse.It is a kind of novel therapeutic mode for safely and effectively aiding in existing clinical drug therapy diabetic nephropathy.

Description

A kind of Diabetic Nephropathy patients nutriment
Technical field
The present invention relates to a kind of Diabetic Nephropathy patients nutriment.
Background technology
Chronic renal disease turns into a kind of major disease for threatening global human health.American-European countries's chronic renal disease The incidence of disease between 6~16%, as the ESRD (uremia) caused by chronic renal disease in global morbidity Rate improves year by year, and poor prognosis, spends height, heavy burden is brought to global Health Investment.With China's national economy and health Report the incidence of disease of chronic renal disease in the big cities such as the development of cause, the raising of living standards of the people, Shanghai, Beijing, Guangzhou It is similar to developed country, even more high.At present, the dialysis center of Chinese situation of all-level hospitals is more overstaffed, to family and state's family property Political affairs bring heavy burden.Diabetes have become the maximum seed of trouble for causing chronic renal disease at present, account for overall pathogenic factor More than 35%.Diabetic nephropathy is one of most important complication of diabetic.The incidence of disease in China is also in rising trend, mesh Preceding first reason for turning into End-stage renal disease.
Diabetic nephropathy is that the hyperglycaemia of diabetes causes renal function lesion caused by kidney Microangiopathy.Due to Complicated metabolic disorder also be present in it, once End-stage renal disease is developed into, often than the treatment more spine of other kidney troubles Hand, therefore a kind of effective therapeutic modality of new type of safe is found for delaying the significant of diabetic nephropathy.
The content of the invention:
The present invention provides a kind of Diabetic Nephropathy patients nutriment, to solve existing kind of Diabetic Nephropathy patients nutrition Product can not play protection renal, prevent the technical problem that sb.'s illness took a turn for the worse.
In order to solve the above technical problems, the present invention adopts the technical scheme that:
A kind of Diabetic Nephropathy patients nutriment, it is characterized in that, including following components:Fruit-vegetable fibre, prebiotics, oat Glucan and probiotics.
The fruit-vegetable fibre, prebiotics, oat beta-glucan and probiotics proportion are respectively:
Fruit-vegetable fibre 40%-60%
Prebiotics 10%-30%
Bitter Melon P.E 5%-15%
Probiotics 10%-30%.
Diabetic Nephropathy patients nutriment no longer contains other components.
The fruit-vegetable fibre, prebiotics, oat beta-glucan and probiotics proportion are respectively:
Fruit-vegetable fibre 50%
Prebiotics 20%
Oat beta-glucan 10%
Probiotics 20%.
After above-mentioned technical proposal is employed, because fruit-vegetable fibre, prebiotics, oat beta-glucan and probiotics adjust human body Gut flora balance can target " insulin resistance path " by fat metabolism approach, improve the high blood in diabetic nephropathy source The symptom of fat and hyperglycaemia;Suppress urotoxic generation by targetting " inflammation urotoxin path " simultaneously, protected so as to play kidney Shield, prevents the effect that sb.'s illness took a turn for the worse.It is a kind of safely and effectively to aid in existing the new of clinical drug therapy diabetic nephropathy to control Treatment mode.Nutriment novelty of the present invention by suppress " insulin resistance path " solve diabetic nephropathy it is intractable by In the state of an illness caused by metabolic disorder is unmanageable the problem of, also suppress to cause uremia to be produced by targetting " inflammation urotoxin path " Raw urotoxic generation.So as to play protection renal, prevent the effect that sb.'s illness took a turn for the worse.
Embodiment
A kind of Diabetic Nephropathy patients nutriment, including following components:Fruit-vegetable fibre, prebiotics, oat beta-glucan and Probiotics.Fruit-vegetable fibre, prebiotics, oat beta-glucan and probiotics proportion are respectively:
Fruit-vegetable fibre 40%-60%
Prebiotics 10%-30%
Oat beta-glucan 5%-15%
Probiotics 10%-30%
The specific proportioning such as following table of each component (so that gross weight is 100 grams as an example):
Because human oral's nutriment amount is limited, especially patient, this Diabetic Nephropathy patients do not contain it with nutriment Best results during its component, it is evident that due to being nutriment, being mixed into other harmless components can certainly.This hair Bright nutriment, it is mainly used in the auxiliary treatment of diabetic nephropathy, and it can be led to by adjusting human body intestinal canal flora balance Fat metabolism approach targeting " insulin resistance path " is crossed, improves the high fat of blood in diabetic nephropathy source and the symptom of hyperglycaemia; Suppress urotoxic generation by targetting " inflammation urotoxin path " simultaneously, so as to play protection renal, prevent what sb.'s illness took a turn for the worse Effect.It is a kind of novel therapeutic mode for safely and effectively aiding in existing clinical drug therapy diabetic nephropathy.
1st, the mechanism of action of recipe ingredient
Target " insulin resistance path "
" insulin resistance " is the unmanageable basic reason of the blood glucose of diabetes, and hyperglycaemia causes skin lesion in tiny blood vessels Evil, glomerulus vascular lesion is shown as in kidney, causes albuminuria, blood urine, and clinic is referred to as diabetic nephropathy.It is of the present invention Nutriment is balanced by adjusting gut flora, improves fat metabolic disturbance environment.Disorders of lipid metabolism such as high triglyceride and Gao You Closely related from fatty acidaemia etc. and insulin resistance, hypertriglyceridemia and high free fatty acid hyperlipemia further aggravate Insulin resistance.By improving fat metabolism path, suppress the generation of bile acid, inflammatory factor, TMAO, releasing causes The adverse factor of pancreas islet resistance.Meanwhile by improving fat metabolism path, promote the generation of short chain fatty acids, increase insulin Sensitiveness.So as to be controlled from source because sb.'s illness took a turn for the worse for diabetic nephropathy caused by complicated metabolic disorder.
Target " inflammation urotoxin path "
The generation of inflammation and urotoxic generation, it is to cause the arch-criminal that sb.'s illness took a turn for the worse in chronic kidney disease.Kidney and intestines Two-way interaction between road flora be present, referred to as intestines-kidney axle bacterium will produce some potential toxic metabolites, and slow Property nephrosis may influence the composition of gut flora and destroy gut barrier function, promote endotoxin and bacterium to enter blood from enteric cavity Circulation.Nutriment of the present invention is balanced by adjusting gut flora, is protected the integrality of intestinal mucosa, is directly suppressed " inflammation The activation of uremia path ", reduce because diet and bacteriogenic inflammatory factor and urotoxin enter blood by " intestines-kidney axle " Liquid circulates, and inducing chronic kidney disease, sb.'s illness took a turn for the worse, or even uremic generation.
Synergy mechanism
Diabetic nephropathy, it is both that diabetes hyperglycaemia causes kidney injury caused by Microangiopathy, and it is a kind of tight The chronic renal disease of weight.Therefore, effective treatment needs to take into account the common feature of diabetes and chronic kidney disease.The present invention passes through Regulation and control for gut flora balance, not only targeting " insulin resistance path " solve the problems, such as diabetes, also may be used The puzzlement constantly deteriorated with targeting " inflammation urotoxin path " solution chronic kidney disease.Meanwhile " insulin resistance path " Improve the reduction that can promote that urotoxin generates in " inflammation urotoxin path ", suppress the deterioration of chronic kidney disease and uremic hair It is raw.The protection of gut barrier in " inflammation urotoxin path ", can " insulin resistance path " provide play one's part to the full Place.Therefore, the regulation and control that nutriment of the present invention is balanced by gut flora, targeting " insulin resistance path " and " inflammation urotoxin path ", can effective auxiliary treatment diabetic nephropathy.

Claims (4)

1. a kind of Diabetic Nephropathy patients nutriment, it is characterized in that, including following components:Fruit-vegetable fibre, prebiotics, oat Portugal Glycan and probiotics.
2. Diabetic Nephropathy patients nutriment as claimed in claim 1, it is characterized in that, the fruit-vegetable fibre, prebiotics, swallow Wheat glucan and probiotics proportion are respectively:
Fruit-vegetable fibre 40%-60%
Prebiotics 10%-30%
Oat beta-glucan 5%-15%
Probiotics 10%-30%.
3. Diabetic Nephropathy patients nutriment as claimed in claim 1 or 2, it is characterized in that, the Diabetic Nephropathy patients No longer contain other components with nutriment.
4. Diabetic Nephropathy patients nutriment as claimed in claim 3, it is characterized in that, the fruit-vegetable fibre, prebiotics, swallow Wheat glucan and probiotics proportion are respectively:
Fruit-vegetable fibre 50%
Prebiotics 20%
Oat beta-glucan 10%
Probiotics 20%.
CN201710649713.4A 2017-08-02 2017-08-02 A kind of Diabetic Nephropathy patients nutriment Pending CN107495362A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201710649713.4A CN107495362A (en) 2017-08-02 2017-08-02 A kind of Diabetic Nephropathy patients nutriment
PCT/CN2017/105663 WO2019024248A1 (en) 2017-08-02 2017-10-11 Nutritional product for diabetic nephropathy patients

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710649713.4A CN107495362A (en) 2017-08-02 2017-08-02 A kind of Diabetic Nephropathy patients nutriment

Publications (1)

Publication Number Publication Date
CN107495362A true CN107495362A (en) 2017-12-22

Family

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Family Applications (1)

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Country Status (2)

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CN (1) CN107495362A (en)
WO (1) WO2019024248A1 (en)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101317666A (en) * 2008-07-18 2008-12-10 罗文礼 High-efficiency composite food cellulose and preparation method thereof
CN102448478A (en) * 2009-03-25 2012-05-09 科·汉森有限公司 Use of probiotics to ameliorate diet-induced insulin resistance
CN102550916A (en) * 2012-02-04 2012-07-11 王姗思 Food for treating diabetic nephropathy (DN)
CN104664329A (en) * 2015-03-04 2015-06-03 益点堂(上海)生物科技有限公司 Sugar-free probiotics powder and preparation method thereof
CN105661547A (en) * 2016-01-22 2016-06-15 湖南营养树科技有限公司 Probiotics and Bombyx mori compounded diabetic patient nutritional supplement
CN106418544A (en) * 2016-06-30 2017-02-22 山东凤凰生物有限公司 Protein and probiotic composite food with weight losing effect
CN106619743A (en) * 2016-12-28 2017-05-10 山东龙力生物科技股份有限公司 Probiotic solid drink with hypoglycaemic effect and preparation method of probiotic solid drink
CN106689959A (en) * 2017-01-10 2017-05-24 唐山金鼎盛生物科技有限公司 Solid beverage for assisting blood glucose regulation
CN106954862A (en) * 2017-03-31 2017-07-18 北京市永康年健康科技有限责任公司 Edible fiber products and preparation method thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106173829A (en) * 2016-07-06 2016-12-07 武汉好多多生物科技有限公司 A kind of processing method of ourishing rice flour
CN106666728A (en) * 2016-12-23 2017-05-17 上海奥医生物医药科技有限公司 Special clinical nutrient composition for gestational diabetes and preparation method of nutrient composition

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101317666A (en) * 2008-07-18 2008-12-10 罗文礼 High-efficiency composite food cellulose and preparation method thereof
CN102448478A (en) * 2009-03-25 2012-05-09 科·汉森有限公司 Use of probiotics to ameliorate diet-induced insulin resistance
CN102550916A (en) * 2012-02-04 2012-07-11 王姗思 Food for treating diabetic nephropathy (DN)
CN104664329A (en) * 2015-03-04 2015-06-03 益点堂(上海)生物科技有限公司 Sugar-free probiotics powder and preparation method thereof
CN105661547A (en) * 2016-01-22 2016-06-15 湖南营养树科技有限公司 Probiotics and Bombyx mori compounded diabetic patient nutritional supplement
CN106418544A (en) * 2016-06-30 2017-02-22 山东凤凰生物有限公司 Protein and probiotic composite food with weight losing effect
CN106619743A (en) * 2016-12-28 2017-05-10 山东龙力生物科技股份有限公司 Probiotic solid drink with hypoglycaemic effect and preparation method of probiotic solid drink
CN106689959A (en) * 2017-01-10 2017-05-24 唐山金鼎盛生物科技有限公司 Solid beverage for assisting blood glucose regulation
CN106954862A (en) * 2017-03-31 2017-07-18 北京市永康年健康科技有限责任公司 Edible fiber products and preparation method thereof

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