CN102550916A - Food for treating diabetic nephropathy (DN) - Google Patents
Food for treating diabetic nephropathy (DN) Download PDFInfo
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- CN102550916A CN102550916A CN2012100242016A CN201210024201A CN102550916A CN 102550916 A CN102550916 A CN 102550916A CN 2012100242016 A CN2012100242016 A CN 2012100242016A CN 201210024201 A CN201210024201 A CN 201210024201A CN 102550916 A CN102550916 A CN 102550916A
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Abstract
The invention relates to a food for treating diabetic nephropathy, which is made from the following raw materials by weight parts: 20-50 parts of total polysaccharides of Astragalus mongholicus, 15-60 parts of rehmannia polysaccharides, 1-4 parts of total glycosides of Rhizoma Alismatis, 2-4 parts of paeoniflorin, 15-36 parts of polysaccharides of plantain seed, 1-3 parts of methionine, 2-6 parts of taurine, 1-3 parts of choline, 1-3 parts of inositol and 400-1,000 parts of water extract of corn stigma.
Description
Technical field
The present invention relates to a kind of food that is used for diabetic nephropathy.
Background technology
Diabetic nephropathy (Diabetic Nephro Pathy) is called for short DN (as follows); Be called " diabetes glomerulosclerosis "; Be the diabetes common complication, be a kind of be main glomerulus pathology with the vascular lesion, cause the general microangiopathies; DN be diabetes the most serious with one of the most common chronic complicating diseases, its incidence of disease according to external report have up to 4.5%.About 1/3 insulin-dependent diabetes mellitus and 1/5 Non-Insulin Dependent Diabetes Mellitus finally develop into DN, and the diabetic died from DN renal failure person and accounts for 53% after 10～19 years, and the death rate has occupied the 3rd afterwards of tumour, cardiovascular and cerebrovascular diseases.In a single day ephrosis takes place and becomes in the diabetic, continuation urine albumen occurs, and then the state of an illness is irreversible, often carries out sexual development until renal failure, is one of diabetic's main causes of death.Still do not have effective ways up to now and can control DN functional lesion nature process, WHO prediction 21 century diabetic nephropathy will be popular in developing country, how effectively prevent and treat diabetic nephropathy, be the focus and the difficult problem of world's medical research.
The mechanism of diabetic nephropathy is the glomerular basement membrane thickening that causes owing to diabetes usually, and mesentery expansion and extracellular matrix hyperplasia cause glomerulosclerosis.The mesangial cell pathology has important role in the incidence and development process of diabetic nephropathy, mesangial cell is the main component of glomerulus, accounts for the 30-40% of messangial cell sum.Mesangial cell has multiple function; Like secretory cell matrix, generation cell factor; Engulfing the contractile function of removing macromolecular substances and similar smooth muscle cell, be one of main cell of secretion generation extracellular matrix (ECM), and the ECM gathering is the key mechanism of glomerulosclerosis.
In recent years, occurred some successively and be used for the food of diabetes, kept on a diet, the drainage of white egg of trace and protein in the minimizing urine; Reduce serum creatinine and urea nitrogen, reduce blood sugar and glucose in urine, regulate blood fat, improve blood flow and become and renal function, delay the glomerulus pathology; It is loose to suppress kidney, reduces urine albumen, and the protection renal function is corrected lipid-metabolism; Reduce blood sugar, Green Tea Extract, immunoloregulation function; But, still there is not the food that is specifically designed to diabetic nephropathy at present, the food of diabetic nephropathy is in case by successfully research and development, have very big market value.
Summary of the invention
The object of the invention just is to provide a kind of food that is used for diabetic nephropathy reliably.
Another object of the present invention provides the preparation method of above-mentioned food.
A kind of food that is used for diabetic nephropathy of the present invention; Be to process: 20～50 parts of total polysaccharides of astragalus membranaceus, 15～60 parts of Dihuang polysaccharides, 1～4 part of the total glycosides of rhizoma alismatis, 2～4 parts of Paeoniflorins, 15～36 parts of plantago asiatica linne polyoses, 1～3 part of methionine by the raw material of following weight portion; 2～6 parts of taurines; 1～3 part in choline, 1～3 part of inositol, 400～1000 parts of corn stigma water extracts.
A kind of food that is used for diabetic nephropathy of the present invention; Be to process: 30 parts of total polysaccharides of astragalus membranaceus, 40 parts of Dihuang polysaccharides, 3 parts of the total glycosides of rhizoma alismatis, 3 parts of Paeoniflorins, 30 parts of plantago asiatica linne polyoses, 2 parts of methionine by the raw material of following weight portion; 5 parts of taurines; 2 parts in choline, 2 parts of inositols, 600 parts of corn stigma water extracts.
A kind of preparation method who is used for the food of diabetic nephropathy of the present invention comprises the following steps:
(1) said other raw materials except that the corn stigma water extract are mixed, obtain mixture, subsequent use;
(2) with corn stigma water refluxing extraction 2～5 times, the extracting liquid filtering that obtains, merging filtrate, filtrating concentrates, the concentrate that obtains, drying obtains powder, and is subsequent use;
(3) combined mixture, powder have been prepared into food component of the present invention.
The present invention can also add an amount of wheaten starch or cornstarch with food component of the present invention, and cellulose is pressed into biscuit.
The present invention also adds acceptable auxiliary on the bromatology and learns any formulation of the above with regard to food prepared therefrom.
The active component of food of the present invention can add the above formulation of acceptable auxiliary food prepared therefrom on the bromatology.For example add disintegrant, lubricant, adhesive etc. and be prepared into any peroral dosage form commonly used, like capsule, sheet, ball, particle, oral liquid, bread, salad etc. with the method for routine.
In a word, the food for preparing among the present invention is used for diabetic nephropathy, and is reliable for effect, and no obvious toxic and side effects is convenient to the patient and is taken for a long time.
Embodiment 1
A kind of food that is used for diabetic nephropathy of the present invention; Be to process: the total glycosides of total polysaccharides of astragalus membranaceus 20, Dihuang polysaccharide 15, rhizoma alismatis 1, Paeoniflorin 2, plantago asiatica linne polyoses 15, methionine 1 by the raw material of following weight portion (gram); Taurine 2, choline 1, inositol 1, corn stigma water extract 400.
(1) said other raw materials except that the corn stigma water extract are mixed, obtain mixture, subsequent use;
(2) with corn stigma water refluxing extraction 2 times, the extracting liquid filtering that obtains, merging filtrate, filtrating concentrates, the concentrate that obtains, drying obtains powder, and is subsequent use;
(3) combined mixture, powder have been prepared into food component of the present invention, mix with an amount of wheaten starch, cellulose, are pressed into biscuit.
Embodiment 2
A kind of food that is used for diabetic nephropathy of the present invention; Be to process: the total glycosides of total polysaccharides of astragalus membranaceus 50, Dihuang polysaccharide 60, rhizoma alismatis 4, Paeoniflorin 4, plantago asiatica linne polyoses 36, methionine 3 by the raw material of following weight portion (gram); Taurine 6; 3 parts in choline, 3 parts of inositols, 1000 parts of corn stigma water extracts.
(1) said other raw materials except that the corn stigma water extract are mixed, obtain mixture, subsequent use;
(2) with corn stigma water refluxing extraction 5 times, the extracting liquid filtering that obtains, merging filtrate, filtrating concentrates, the concentrate that obtains, drying obtains powder, and is subsequent use;
(3) combined mixture, powder have been prepared into food composition of the present invention, mix with an amount of cornstarch, cellulose, are pressed into biscuit.
Embodiment 3
Food of the present invention is to the effect of diabetic nephropathy model rat
Test material:
The food biscuit that is used for diabetic nephropathy of food group of the present invention: embodiment 2,
The TANGMAIKANG KELI group: TANGMAIKANG KELI, mix (TANGMAIKANG KELI: produced by Zhonghui Pharmacy Co., Ltd., Chengdu) with common rat feed according to the ratio of 1:10.
Model control group: common rat feed
Normal control group: common rat feed
Animal used as test: the SD rat is the cleaning level.
Test method:
Choose body weight and be 50 of the male SD rats of 220～240g, after the observation, measure body weight; According to the prerun result; Except that 10 rats of normal control group, all the other rats are according to tail vein injection Streptozotocin of 45mg/kg dosage, and STZ concentration is 0.1mmol/L, pH4.2 citrate buffer.Injected back 72 hours, rat tail vein is got blood and is surveyed blood sugar, and fasting 3 hours selects the animal of blood glucose value >=15.0mmol/L to divide into groups.
Test period: 30 days
The test testing result is following:
Table 1 food of the present invention is to the influence of diabetic nephropathy model rat urine amount
| Group | Dosage | Urine amount (ml/24h) | ||
| (the g raw material/kg) | After 5 weeks | After 10 weeks | After 15 weeks | |
| The normal control group | / | 27.9±23.1 | 17.1±3.4 | 14.2±3.7 |
| Model control group | / | 99.7±23.5 | 121.7±23.7 | 92.8±25.2 |
| Food of the present invention | 8.0 | 71.8±41.2 | 98.2±19.2 | 84.1±23.1 |
| Food of the present invention | 16.0 | 63.4±32.7 | 85.3±22.5 | 75.2±19.7 |
| Food of the present invention | 32.0 | 57.1±23.1 | 75.2±23.1 | 68.2±23.2 |
| Sugar arteries and veins chaff group | 5g particle/kg | 59.1±21.6 | 78.3±28.7 | 72.9±18.1 |
Annotate: compare with model group
*P＜0.05,
*P＜0.01.
Table 2 food of the present invention is to the influence of diabetic nephropathy model rat 24h urine albumen
| Group | Dosage | Urine albumen (g/L/24h) | ||
| (the g raw material/kg) | After 5 weeks | After 10 weeks | After 15 weeks | |
| The normal control group | / | 0.45±0.16 | 0.32±0.03 | 0.39±0.04 |
| Model control group | / | 0.95±0.22 | 0.98±0.12 | 0.92±0.15 |
| Food of the present invention | 8.0 | 0.78±0.12 | 0.82±0.13 | 0.75±0.16 |
| Food of the present invention | 16.0 | 0.71±0.15 | 0.78±0.15 | 0.71±0.15 |
| Food of the present invention | 32.0 | 0.68±0.13 | 0.67±0.12 | 0.65±0.14 |
| Sugar arteries and veins chaff group | 5g particle/kg | 0.81±0.19 | 0.76±0.12 | 0.74±0.15 |
Annotate: compare * p＜0.05, * * p＜0.01 with model group.
Table 3 food of the present invention is to the influence of diabetic nephropathy model rat 24h urea nitrogen (BUN)
| Group | Dosage | BUN(mmol/L/24h) | ? | |
| (the g raw material/kg) | After 5 weeks | After 10 weeks | After 15 weeks | |
| The normal control group | / | 254.10±92.23 | ?279.8±97.26 | 296.53±75.23 |
| Model control group | / | 121.32±42.29 | ?134.23±47.23 | 168.15±35.47 |
| Food of the present invention | 8.0 | 131.32±23.32 | ?159.31±47.23 | 182.53±89.56 |
| Food of the present invention | 16.0 | 147.92±28.27 | ?175.13±46.05 | 199.52±56.47 |
| Food of the present invention | 32.0 | 178.62±93.39 | ?190.98±86.83 | 229.13±97.23 |
| Sugar arteries and veins chaff group | 5g particle/kg | 125.20±46.78 | ?186.26±55.26 | 212.35±87.54 |
Annotate: compare * p＜0.05 with model group.
Comprehensive above result of the test shows that the present invention has the significant protection effect to the diabetic nephropathy model rat, and dosage is Zao in the high dose onset time ratio.Mainly show following several respects:
(1) control blood sugar: result of the test shows that food of the present invention all can obviously reduce the diabetic nephropathy model rat blood sugar in 5 weeks of administration, 10 weeks, 15 weeks.Early stage control carbohydrate metabolism disturbance is most important, and renal lesions corrected and prevented to glycemic control well can, and renal function also improves.
(2) suppress excretion, the protection renal function that kidney is loose, reduce urine albumen, increase urea nitrogen: the result of the test prompting: medicine high dose of the present invention can significantly reduce the kidney index of DN rat; Can alleviate the process of rat diabetes ephrosis.
(3) in whole process, each treated animal generally in order, behavior is normal, does not see any poisoning manifestations, does not also have animal dead.In the nursing process, food of the present invention increases rat body weight does not have significantly influence, and rat red blood cell sum, content of hemoglobin and total white blood cells are not had obvious influence.The blood biochemistry of rats index there is not obvious influence.Inspection liver,kidney,spleen, stomach and intestine, ovary or testis do not have obviously influence.Explain that the present invention food can use safely.
Embodiment 4
Food of the present invention is to the effect of Diabetic Nephropathy patients
20 routine Diabetic Nephropathy patients are taken the food of the embodiment of the invention 2, and 2 months, one time 20 gram, every day three times;
After 2 months, urine albumen is reduced to 16 people that have of normal level, and invalid 4 people are after cutting out; 16 philtrums have 8 people albumen to occur urinating, adhere to taking the food of the embodiment of the invention 2 once more, and 2 months, one time 20 gram; Every day three times, urine albumen is reduced to 6 people that have of normal level, invalid 2 people;
After 2 months, blood sugar is reduced to 17 people that have of normal level, and invalid 4 people are after cutting out; 17 philtrums have 9 people's fasting blood-glucoses to be higher than 12.3, adhere to taking the food of the embodiment of the invention 2 once more, and 2 months, one time 20 gram; Every day three times, fasting blood-glucose is reduced to 8 people that have of normal level, invalid 1 people.
Claims (4)
1. food that is used for diabetic nephropathy; It is characterized in that it is to be processed by the raw material of following weight portion: 20～50 parts of total polysaccharides of astragalus membranaceus, 15～60 parts of Dihuang polysaccharides, 1～4 part of the total glycosides of rhizoma alismatis, 2～4 parts of Paeoniflorins, 15～36 parts of plantago asiatica linne polyoses, 1～3 part of methionine; 2～6 parts of taurines; 1～3 part in choline, 1～3 part of inositol, 400～1000 parts of corn stigma water extracts.
2. the food that is used for diabetic nephropathy as claimed in claim 2; It is characterized in that it is to be processed by the raw material of following weight portion: 30 parts of total polysaccharides of astragalus membranaceus, 40 parts of Dihuang polysaccharides, 3 parts of the total glycosides of rhizoma alismatis, 3 parts of Paeoniflorins, 30 parts of plantago asiatica linne polyoses, 2 parts of methionine; 5 parts of taurines; 2 parts in choline, 2 parts of inositols, 600 parts of corn stigma water extracts.
3. like the described preparation method who is used for the food of diabetic nephropathy of arbitrary claim in the claim 1～2, it is characterized in that it comprises the following steps:
(1) said other raw materials except that the corn stigma water extract are mixed, obtain mixture, subsequent use;
(2) with corn stigma water refluxing extraction 2～5 times, the extracting liquid filtering that obtains, merging filtrate, filtrating concentrates, the concentrate that obtains, drying obtains powder, and is subsequent use;
(3) combined mixture, powder have been prepared into food of the present invention.
4. the preparation method who is used for the food of diabetic nephropathy as claimed in claim 3 is characterized in that: food component of the present invention is added an amount of wheaten starch or cornstarch, be pressed into biscuit.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100242016A CN102550916A (en) | 2012-02-04 | 2012-02-04 | Food for treating diabetic nephropathy (DN) |
| CN201210261132.0A CN102813112B (en) | 2012-02-04 | 2012-07-26 | Foodstuff for diabetic nephropathy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100242016A CN102550916A (en) | 2012-02-04 | 2012-02-04 | Food for treating diabetic nephropathy (DN) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102550916A true CN102550916A (en) | 2012-07-11 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100242016A Withdrawn CN102550916A (en) | 2012-02-04 | 2012-02-04 | Food for treating diabetic nephropathy (DN) |
| CN201210261132.0A Expired - Fee Related CN102813112B (en) | 2012-02-04 | 2012-07-26 | Foodstuff for diabetic nephropathy |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210261132.0A Expired - Fee Related CN102813112B (en) | 2012-02-04 | 2012-07-26 | Foodstuff for diabetic nephropathy |
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| Country | Link |
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| CN (2) | CN102550916A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104146032A (en) * | 2014-08-11 | 2014-11-19 | 南昌大学 | Method for making semen-plantaginis polysaccharide biscuits |
| CN104814374A (en) * | 2015-05-20 | 2015-08-05 | 山东省农业科学院农产品研究所 | Special instant diluting powder for diabetic nephropathy and preparation method thereof |
| CN106174536A (en) * | 2016-04-17 | 2016-12-07 | 马鞍山聚力科技有限公司 | A kind of ultra micro nutrition prescription preventing and treating urine protein and preparation processing method |
| CN107495362A (en) * | 2017-08-02 | 2017-12-22 | 深圳市领治医学科技有限公司 | A kind of Diabetic Nephropathy patients nutriment |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6149915A (en) * | 1999-09-29 | 2000-11-21 | Shiva Biomedical, Llc | Treatment of diabetic nephropathy and microalbuminuria |
| CN101703617B (en) * | 2009-12-07 | 2011-11-23 | 中日友好医院 | Medicinal composition for treating diabetic nephropathy and preparation method thereof |
| CN102228536B (en) * | 2011-06-09 | 2013-03-13 | 首都医科大学 | Chinese herbal extract for treating diabetic nephropathy and preparation method thereof |
-
2012
- 2012-02-04 CN CN2012100242016A patent/CN102550916A/en not_active Withdrawn
- 2012-07-26 CN CN201210261132.0A patent/CN102813112B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104146032A (en) * | 2014-08-11 | 2014-11-19 | 南昌大学 | Method for making semen-plantaginis polysaccharide biscuits |
| CN104814374A (en) * | 2015-05-20 | 2015-08-05 | 山东省农业科学院农产品研究所 | Special instant diluting powder for diabetic nephropathy and preparation method thereof |
| CN106174536A (en) * | 2016-04-17 | 2016-12-07 | 马鞍山聚力科技有限公司 | A kind of ultra micro nutrition prescription preventing and treating urine protein and preparation processing method |
| CN107495362A (en) * | 2017-08-02 | 2017-12-22 | 深圳市领治医学科技有限公司 | A kind of Diabetic Nephropathy patients nutriment |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102813112B (en) | 2014-07-02 |
| CN102813112A (en) | 2012-12-12 |
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| Date | Code | Title | Description |
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| PB01 | Publication | ||
| C04 | Withdrawal of patent application after publication (patent law 2001) | ||
| WW01 | Invention patent application withdrawn after publication |
Open date: 20120718 |
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| DD01 | Delivery of document by public notice |
Addressee: Wang Pansi Document name: Notification of Approving Refund |