CN104055014A - Food for diabetic nephropathy - Google Patents
Food for diabetic nephropathy Download PDFInfo
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- CN104055014A CN104055014A CN201410335505.3A CN201410335505A CN104055014A CN 104055014 A CN104055014 A CN 104055014A CN 201410335505 A CN201410335505 A CN 201410335505A CN 104055014 A CN104055014 A CN 104055014A
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- 235000013305 food Nutrition 0.000 title claims abstract description 45
- 208000007342 Diabetic Nephropathies Diseases 0.000 title claims abstract description 32
- 208000033679 diabetic kidney disease Diseases 0.000 title claims abstract description 32
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- 150000004676 glycans Chemical class 0.000 claims abstract description 15
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 15
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 239000000284 extract Substances 0.000 claims abstract description 11
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims abstract description 7
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- 229960001231 choline Drugs 0.000 claims abstract description 7
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- 229930182470 glycoside Natural products 0.000 claims abstract description 7
- 150000002338 glycosides Chemical class 0.000 claims abstract description 7
- 229930182817 methionine Natural products 0.000 claims abstract description 7
- YKRGDOXKVOZESV-UHFFFAOYSA-N paeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(CO)O5)O)CC3(O)OC1C24COC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-UHFFFAOYSA-N 0.000 claims abstract description 7
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- 229960000367 inositol Drugs 0.000 claims abstract description 5
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- 239000008107 starch Substances 0.000 claims description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 abstract description 6
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 abstract description 3
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
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- 230000007246 mechanism Effects 0.000 description 2
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 2
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- 230000002641 glycemic effect Effects 0.000 description 1
- 229940094952 green tea extract Drugs 0.000 description 1
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- -1 sheet Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D13/00—Finished or partly finished bakery products
- A21D13/80—Pastry not otherwise provided for elsewhere, e.g. cakes, biscuits or cookies
-
- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
- A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
- A21D2/36—Vegetable material
- A21D2/38—Seed germs; Germinated cereals; Extracts thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Pediatric Medicine (AREA)
- Mycology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses food for diabetic nephropathy. The food for the diabetic nephropathy is prepared by the following raw materials in part by weight: 20 to 50 parts of astragalus total polysaccharide, 15 to 60 parts of rehmannia polysaccharide, 1 to 4 parts of alisma total glycosides, 2 to 4 parts of paeoniflorin, 15 to 36 parts of semen plantaginis polysaccharides, 1 to 3 parts of methionine, 2 to 6 parts of taurine, 1 to 3 parts of choline, 1 to 3 parts of inositol, and 400 to 1,000 parts of corn stigma water extract.
Description
Technical field
The present invention relates to a kind of food for diabetic nephropathy.
Background technology
It is as follows that diabetic nephropathy (Diabetic Nephro Pathy) is called for short DN(), be called " diabetes glomerulosclerosis ", the common complication of diabetes, a kind of taking vascular lesion as main Glomerular lesions, cause general microangiopathies, DN is the most serious and one of the most common chronic complicating diseases of diabetes, its incidence of disease have according to external report up to 4.5%.Approximately 1/3 insulin-dependent diabetes mellitus and 1/5 Non-Insulin Dependent Diabetes Mellitus finally develop into DN, and diabetic, after 10~19 years, dies from DN renal failure person and accounts for 53%, and the death rate has occupied the 3rd afterwards of tumour, cardiovascular and cerebrovascular diseases.Once there is nephropathy in diabetic, there is continuation urine albumen, the state of an illness is irreversible, often carries out sexual development until renal failure is one of diabetic's main causes of death.There is no up to now effective ways and can control DN functional lesion nature process, WHO prediction 21 century diabetic nephropathy will be popular in developing country, how effectively prevent and treat diabetic nephropathy, be focus and a difficult problem for world's medical research.
The mechanism of diabetic nephropathy is the glomerular basement membrane thickening conventionally causing due to diabetes, and mesentery expansion and extracellular matrix hyperplasia, cause glomerulosclerosis.Mesangial cell pathology has extremely important effect in the generation evolution of diabetic nephropathy again, and mesangial cell is the main component of glomerulus, accounts for the 30-40% of messangial cell sum.Mesangial cell has several functions, as secretory cell matrix, generation cell factor, engulfing the contractile function of removing macromolecular substances and similar smooth muscle cell, be one of main cell of secretion generation extracellular matrix (ECM), and ECM gathering is the key mechanism of glomerulosclerosis.
In recent years, there are successively some foods for diabetes, kept on a diet, in minimizing urine, the excretion of Microalbunin and protein, reduces serum creatinine and urea nitrogen, reduction blood sugar and glucose in urine, regulates blood fat, improve blood flow and become and renal function, delay Glomerular lesions, suppress renal hypertrophy, reduce urine albumen, protection renal function, corrects lipid-metabolism, reduces blood sugar, Green Tea Extract, immunoloregulation function; But, there is no at present the food that is specifically designed to diabetic nephropathy, once the food of diabetic nephropathy is is successfully researched and developed, there is very large market value.
Summary of the invention
Object of the present invention is just to provide a kind of reliable food for diabetic nephropathy.
Another object of the present invention is to provide the preparation method of above-mentioned food.
A kind of food for diabetic nephropathy of the present invention is to be made up of the raw material of following weight portion: 20~50 parts of total polysaccharides of astragalus membranaceus, 15~60 parts of Dihuang polysaccharides, 1~4 part of the total glycosides of rhizoma alismatis, 2~4 parts of Paeoniflorins, 15~36 parts of plantago asiatica linne polyoses, 1~3 part of methionine, 2~6 parts of taurines, 1~3 part, choline, 1~3 part of inositol, 400~1000 parts of corn silk water extracts.
A kind of food for diabetic nephropathy of the present invention is to be made up of the raw material of following weight portion: 30 parts of total polysaccharides of astragalus membranaceus, 40 parts of Dihuang polysaccharides, 3 parts of the total glycosides of rhizoma alismatis, 3 parts of Paeoniflorins, 30 parts of plantago asiatica linne polyoses, 2 parts of methionine, 5 parts of taurines, 2 parts, choline, 2 parts of inositols, 600 parts of corn silk water extracts.
The preparation method of a kind of food for diabetic nephropathy of the present invention, comprises the following steps:
(1) described other raw materials except corn silk water extract are mixed, obtain mixture, for subsequent use;
(2) by corn stigma water refluxing extraction 2~5 times, the extracting liquid filtering obtaining, merging filtrate, filtrate is concentrated, and the concentrate obtaining is dry, obtains powder, for subsequent use;
(3) combined mixture, powder, has been prepared into food component of the present invention.
The present invention can also add appropriate wheaten starch or cornstarch by food component of the present invention, and cellulose, is pressed into biscuit.
The present invention also adds acceptable auxiliary material in bromatology to learn any formulation of the above with regard to food prepared therefrom.
The active component of food of the present invention can add the above formulation of acceptable auxiliary material food prepared therefrom in bromatology.For example add disintegrant, lubricant, adhesive etc. to be prepared into any conventional peroral dosage form with conventional method, as capsule, sheet, ball, particle, oral liquid, bread, salad etc.
In a word, the food of preparing in the present invention is for diabetic nephropathy, reliable for effect, without obvious toxic and side effect, is convenient to patient's long-term taking.
Embodiment 1
A kind of food for diabetic nephropathy of the present invention; be by following weight portion (gram) raw material make: total polysaccharides of astragalus membranaceus 20, Dihuang polysaccharide 15, the total glycosides 1 of rhizoma alismatis, Paeoniflorin 2, plantago asiatica linne polyoses 15, methionine 1, taurine 2, choline 1; inositol 1, corn silk water extract 400.
(1) described other raw materials except corn silk water extract are mixed, obtain mixture, for subsequent use;
(2) by corn stigma water refluxing extraction 5 times, the extracting liquid filtering obtaining, merging filtrate, filtrate is concentrated, and the concentrate obtaining is dry, obtains powder, for subsequent use;
(3) combined mixture, powder, has been prepared into food composition of the present invention, mixes with appropriate cornstarch, cellulose, is pressed into biscuit.
Embodiment 2
A kind of food for diabetes of the present invention; be by following weight portion (gram) raw material make: total polysaccharides of astragalus membranaceus 50, Dihuang polysaccharide 60, the total glycosides 4 of rhizoma alismatis, Paeoniflorin 4, plantago asiatica linne polyoses 36, methionine 3, taurine 6, choline 3; inositol 3, corn silk water extract 1000.
(1) described other raw materials except corn silk water extract are mixed, obtain mixture, for subsequent use;
(2) by corn stigma water refluxing extraction 5 times, the extracting liquid filtering obtaining, merging filtrate, filtrate is concentrated, and the concentrate obtaining is dry, obtains powder, for subsequent use;
(3) combined mixture, powder, has been prepared into food composition of the present invention, mixes with appropriate cornstarch, cellulose, is pressed into biscuit.
Embodiment 3
The effect of food of the present invention to diabetic nephropathy model rat
Test material:
The food biscuit for diabetic nephropathy of food group of the present invention: embodiment 2,
TANGMAIKANG KELI group: TANGMAIKANG KELI, mixes (TANGMAIKANG KELI: produced by Zhonghui Pharmacy Co., Ltd., Chengdu) with common rat feed according to the ratio of 1:10.
Model control group: common rat feed
Animal used as test: SD rat is clean level.
Test method:
Choose body weight and be 50 of the male SD rats of 220 ~ 240g, after observation, measure body weight, according to pre-test result, except 10 rats of Normal group, all the other rats are according to tail vein injection Streptozotocin of 45mg/kg dosage, and STZ concentration is 0.1mmol/L, pH4.2 citrate buffer.Inject latter 72 hours, rat tail vein is got blood and is surveyed blood sugar, and the animal grouping of blood glucose value >=15.0mmol/L is selected in fasting 3 hours.
Test period: 30 days
Test testing result is as follows:
The impact of table 1 food of the present invention on diabetic nephropathy model rat urine amount
Group | Dosage | Urine amount (ml/24h) | ||
(g raw material/kg) | After 5 weeks | After 10 weeks | After 15 weeks | |
Normal group | / | 27.9±23.1 | 17.1±3.4 | 14.2±3.7 |
Model control group | / | 99.7±23.5 | 121.7±23.7 | 92.8±25.2 |
Food of the present invention | 8.0 | 71.8±41.2 | 98.2±19.2 | 84.1±23.1 |
Food of the present invention | 16.0 | 63.4±32.7 | 85.3±22.5 | 75.2±19.7 |
Food of the present invention | 32.0 | 57.1±23.1 | 75.2±23.1 | 68.2±23.2 |
Sugar arteries and veins chaff group | 5g particle/kg | 59.1±21.6 | 78.3±28.7 | 72.9±18.1 |
Note: with relatively * p<0.05 of model group, * * p<0.01.
The impact of table 2 food of the present invention on diabetic nephropathy model rat 24h urine albumen
Group | Dosage | Urine amount (ml/24h) | ||
(g raw material/kg) | After 5 weeks | After 10 weeks | After 15 weeks | |
Normal group | / | 0.45±0.16 | 0.32±0.03 | 0.39±0.04 |
Model control group | / | 0.95±0.22 | 0.98±0.12 | 0.92±0.15 |
Food of the present invention | 8.0 | 0.78±0.12 | 0.82±0.13 | 0.75±0.16 |
Food of the present invention | 16.0 | 0.71±0.15 | 0.78±0.15 | 0.71±0.15 |
Food of the present invention | 32.0 | 0.68±0.13 | 0.67±0.12 | 0.65±0.14 |
Sugar arteries and veins chaff group | 5g particle/kg | 0.81±0.19 | 0.76±0.12 | 0.74±0.15 |
Note: with relatively * p<0.05 of model group, * * p<0.01.
The impact of table 3 food of the present invention on diabetic nephropathy model rat urea nitrogen (BUN)
Group | Dosage | Urine amount (ml/24h) | ||
(g raw material/kg) | After 5 weeks | After 10 weeks | After 15 weeks | |
Normal group | / | 254.10±92.23 | 279.8±97.26 | 296.53±75.23 |
Model control group | / | 121.32±42.29 | 134.23±47.23 | 168.15±35.47 |
Food of the present invention | 8.0 | 131.32±23.32 | 159.31±47.23 | 182.53±89.56 |
Food of the present invention | 16.0 | 147.92±28.27 | 175.13±46.05 | 199.52±56.47 |
Food of the present invention | 32.0 | 178.62±93.39 | 190.98±86.83 | 229.13±97.23 |
Sugar arteries and veins chaff group | 5g particle/kg | 125.20±46.78 | 186.26±55.26 | 212.35±87.54 |
Note: with relatively * p<0.05 of model group.
Comprehensive above result of the test shows, the present invention has significant protective effect to diabetes model rat, and high dose onset time compare in dosage Zao.Main discovery in following several respects:
(1) control blood sugar: result of the test show food of the present invention administration 5 weeks, within 10 weeks, 15 weeks, all can obviously reduce diabetic nephropathy model rat blood sugar.Early stage control carbohydrate metabolism disturbance is most important, and renal lesions be corrected and be prevented to glycemic control well can, and renal function also improves.
(2) suppress renal hypertrophy, reduce excretion, the protection renal function urinating albumen, increase urea nitrogen: result of the test prompting: medicine high dose of the present invention can significantly reduce the renal index of DN rat; Can alleviate the process of Diabetic Nephropathy.
(3) in whole process, each treated animal general status is good, and behavior is normal, has no any poisoning manifestations, also without animal dead.In nursing process, food of the present invention increases and has no significant effect rat body weight, and Rat Erythrocytes sum, content of hemoglobin and total white blood cells are had no significant effect.Blood biochemistry of rats index is had no significant effect.Check liver,kidney,spleen, stomach and intestine, ovary or testis, have no significant effect.Illustrate that food of the present invention can use safely.
Embodiment 4
The effect of food of the present invention to Diabetic Nephropathy patients
20 routine Diabetic Nephropathy patients are taken the food of the embodiment of the present invention 2,2 months, one time 20 grams, every day three times;
After 2 months, urine albumen is reduced to 16 people that have of normal level, and invalid 4 people, after cutting out, in 16 people, have 8 people to occur urinating albumen, again adhere to taking the food of the embodiment of the present invention 2,2 months, one time 20 grams, every day three times, urine albumen is reduced to 6 people that have of normal level, invalid 2 people;
After 2 months, blood sugar reduces by 17 people that have of a normal level, and invalid 4 people, after cutting out, in 17 people, have 9 people's fasting blood-glucoses higher than 12.3, again adhere to taking the food of the embodiment of the present invention 2,2 months, one time 20 grams, every day three times, fasting blood-glucose is reduced to 8 people that have of normal level, invalid 1 people.
Claims (4)
1. for a food for diabetic nephropathy, it is characterized in that it is to be made up of the raw material of following weight portion: 20~50 parts of total polysaccharides of astragalus membranaceus, 15~60 parts of Dihuang polysaccharides, 1~4 part of the total glycosides of rhizoma alismatis, 2~4 parts of Paeoniflorins, 15~36 parts of plantago asiatica linne polyoses, 1~3 part of methionine, 2~6 parts of taurines, 1~3 part, choline, 1~3 part of inositol, 400~1000 parts of corn silk water extracts.
2. the food for diabetic nephropathy as claimed in claim 2, is characterized in that it is to be made up of the raw material of following weight portion: 30 parts of total polysaccharides of astragalus membranaceus, 40 parts of Dihuang polysaccharides, 3 parts of the total glycosides of rhizoma alismatis, 3 parts of Paeoniflorins, 30 parts of plantago asiatica linne polyoses, 2 parts of methionine, 5 parts of taurines, 2 parts, choline, 2 parts of inositols, 600 parts of corn silk water extracts.
3. the preparation method of the food for diabetic nephropathy as described in arbitrary claim in claim 1 ~ 2, is characterized in that it comprises the following steps:
(1) described other raw materials except corn silk water extract are mixed, obtain mixture, for subsequent use;
(2) by corn stigma water refluxing extraction 2~5 times, the extracting liquid filtering obtaining, merging filtrate, filtrate is concentrated, and the concentrate obtaining is dry, obtains powder, for subsequent use;
(3) combined mixture, powder, has been prepared into food component of the present invention.
4. the preparation method of the food for diabetic nephropathy as claimed in claim 3, is characterized in that: food component of the present invention is added to appropriate wheaten starch or cornstarch, be pressed into biscuit.
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CN201410335505.3A CN104055014A (en) | 2014-07-15 | 2014-07-15 | Food for diabetic nephropathy |
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CN201410335505.3A CN104055014A (en) | 2014-07-15 | 2014-07-15 | Food for diabetic nephropathy |
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