CN107475812A - 一种静电纺制备壳聚糖/姜黄素纳米抗菌敷料的方法 - Google Patents

一种静电纺制备壳聚糖/姜黄素纳米抗菌敷料的方法 Download PDF

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CN107475812A
CN107475812A CN201710810790.3A CN201710810790A CN107475812A CN 107475812 A CN107475812 A CN 107475812A CN 201710810790 A CN201710810790 A CN 201710810790A CN 107475812 A CN107475812 A CN 107475812A
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邵明
舒黎幼
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Sharp Bio Tech Ltd Suzhou One Hundred
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Abstract

本发明涉及一种静电纺制备壳聚糖/姜黄素纳米抗菌敷料的方法，包括：（1）壳聚糖纺丝液的配制：将壳聚糖在搅拌下缓慢加入到一定体积的溶剂中，搅拌至壳聚糖完全溶解。停止搅拌，超声处理15 min，进行脱气，得到纺丝溶液；（2）药物溶液的配制：将姜黄素加入到乙醇中，超声15分钟，至完全溶解；（3）将步骤（2）的药物溶液全部加入步骤（1）的聚合物溶液，继续搅拌8‑12小时，得到橙黄色的含有药物的聚合物溶液，超声处理15分钟进行脱气，得到纺丝溶液；（4）采用上述的纺丝溶液进行静电纺丝，得到纳米抗菌敷料，最后真空干燥，即得。本发明方法操作简单，耗时较少，原材料廉价易得，可获得直径和孔径在纳米级的膜材料，适用于规模化生产。

Description

一种静电纺制备壳聚糖/姜黄素纳米抗菌敷料的方法
技术领域
本发明属于静电纺纳米纤维垫的制备领域，特别涉及一种静电纺制备壳聚糖/姜黄素纳米抗菌敷料的方法。
背景技术
随着对创伤愈合的认识不断加深，以及目前的敷料所存在的各种问题，人们对于新一代的功能性敷料提出了更高的要求。理想的敷料具有以下功能：1、吸收创面过多的伤口渗液，维持伤口湿润的微环境；2、使用方便，不粘连，减轻病人痛苦；3、允许伤口与外界环境的气体交换，同时可以阻隔创面与外界环境，隔离细菌及致病微生物；4、敷料的结构和组成最好具有仿生功能，能够模拟天然的细胞外基质的结构和组成，促进创面的愈合。
静电纺丝纳米抗菌敷料的多孔结构使之具有很好的透气性，而其孔径又可以控制到足够小以阻挡细菌的入侵，因而非常适合用做皮肤敷料，此外静电纺丝制品具有很高的比表面积，可以大量携载包括抗菌药物在内的多种药物，能促进受损皮肤的恢复。
姜黄素为常用中药姜黄根茎中的有效成分。具有抗炎、抗菌、抗氧化、降血脂等药理作用。壳聚糖广泛存在于虾、蟹等节肢动物的外壳中， 在自然界每年合成的量仅次于纤维素，有着广泛的用途。壳聚糖经脱乙酰基后制得脱乙酰壳聚糖，具有良好抗感染，促进伤口愈合作用。
本发明以壳聚糖和姜黄素两种生物材料为主要原料，综合利用壳聚糖优良的抗菌和促进伤口愈合功能，及姜黄素的抗菌、消炎作用，发挥两种成分的协同效应，同时使通过静电纺丝制备的敷料膜具有仿生结构，模拟天然细胞外基质的结构和组成，应用于创面时不仅能够提供抗菌消炎的作用，同时也能促进细胞的粘附、迁移和增殖，从而促进创面的愈合。目前，还未见类似结构和组成的纳米抗菌敷料。
发明内容
本发明所要解决的技术问题是提供一种静电纺制备壳聚糖/姜黄素纳米抗菌敷料的方法，该方法快速、简便、廉价、高效，批量制备及规模化生产。
本发明的一种静电纺制备壳聚糖/姜黄素纳米抗菌敷料的方法，包括：
（1）壳聚糖的配制：将壳聚糖在搅拌下缓慢加入到一定体积的溶剂中，搅拌至壳聚糖完全溶解。停止搅拌，超声处理15 min ，进行脱气，得到纺丝溶液；
（2）药物溶液的配制：将一定量的姜黄素加入到乙醇中，超声15分钟，至完全溶解；
（3）将步骤（2）的药物溶液全部加入步骤（1）的聚合物溶液，继续搅拌8-12小时，得到橙黄色的含有药物的聚合物溶液，超声处理15 min 进行脱气，得到纺丝溶液；
（4）采用上述的纺丝溶液进行静电纺丝，得到纳米抗菌敷料，最后真空干燥，即得。
步骤（1）所述的溶剂为质量浓度为80~90%的乙酸。
步骤（1）得到的纺丝液中壳聚糖的质量浓度为2-8 wt.%。
步骤（2）得到的药物溶液中姜黄素的质量浓度为1-5wt.%。
步骤（3）得到的纺丝溶液中，药物溶液和壳聚糖纺丝液的质量比在1：2~1：4。
步骤（4）所述的静电纺丝中注射器规格为5 mL，针头内径为0.4~0.7 mm，接收屏采用铝箔接地接收，针头与接收屏的距离为10～20 cm。
步骤（4）所述的静电纺丝过程中喷出流速为0.5～1.5 mL/h。
本发明的方法快速、简便、廉价、高效，适合批量制备壳聚糖/姜黄素纳米抗菌敷料。
有益效果
（1）本发明方法操作简单，耗时较少，可获得直径和孔径在纳米级的膜材料，适用于规模化生产；
（2）本发明所使用的原材料廉价易得，具有良好的亲水性和抗菌性能。
附图说明
图1为壳聚糖/姜黄素纳米抗菌敷料的电镜照片图；
图2为壳聚糖/姜黄素纳米抗菌敷料的亲水性能测试图；
图3为壳聚糖/姜黄素纳米抗菌敷料的抗菌性能测试图。
具体实施方式
下面结合具体实施例，进一步阐述本发明。应理解，这些实施例仅用于说明本发明而不用于限制本发明的范围。此外应理解，在阅读了本发明讲授的内容之后，本领域技术人员可以对本发明作各种改动或修改，这些等价形式同样落于本申请所附权利要求书所限定的范围。
实施例1
静电纺制备壳聚糖/姜黄素纳米抗菌敷料的制备方法包括如下步骤：
（1）壳聚糖纺丝液的配制：配制质量浓度为6%的壳聚糖溶液15 ml，溶剂为80~90%的乙酸，搅拌3小时，至完全溶胀；然后在室温下搅拌12小时至完全溶解，得到聚合物溶液呈透明状；
（2）药物溶液的配制：配制质量浓度为4%的姜黄素溶液5 ml，溶剂为乙醇，超声15分钟，至完全溶解；
（3）将步骤（2）的药物溶液5 mL全部加入步骤（1）的15 ml聚合物溶液，继续搅拌10小时，得到橙黄色的含有药物的聚合物溶液，超声处理15分钟进行脱气，得到纺丝溶液；
（4）用5 ml注射器（针头内径为0.4~0.7 mm）抽取步骤（3）中壳聚糖/姜黄素纺丝液，固定在静电纺丝装置上，固定静电压为12 kv，接收距离为12 cm，喷射流速为1.0 mL/h，进行电纺，得到壳聚糖/姜黄素复合纳米纤维膜；
（5）将收集到的膜放入真空干燥器中干燥24 h 以上，备用。
依照以上步骤所得到壳聚糖/姜黄素纳米抗菌敷料微观电镜照片见图1。由图可见，制备的姜黄素纳米纤维垫均一，纤维直径在纳米范围内，其具有较高的孔隙率，可作为一种良好的纳米敷料。
实施例2
静电纺制备壳聚糖/姜黄素纳米抗菌敷料的亲水性能测试，包括如下步骤：
将壳聚糖/姜黄素膜置于水平面，采用OCA40型接触角测量仪（德国Dataphysics公司）检测去离子水滴入干燥样品纤维膜表面时水滴与膜表面的接触角，观察分析样品表面的亲水性，接触角见图2。由图2可见，本发明制备的壳聚糖/姜黄素纳米抗菌敷料具有较好的亲水性。
实施例3
含壳聚糖微球的面膜抗菌性能测定，包括如下步骤：
步骤1：采用美国临床实验室标准化研究所的纸片扩散法研究纳米纤维的抗菌活性（MIC）。在评估中，大肠杆菌进被选定为代表的微生物，并培养在Lauria肉汤（LB）和营养肉汤琼脂平板（NB）。
步骤2：将实施例1中的壳聚糖/姜黄素纳米敷料剪成直径1 cm 规格的试样，进行120ºC蒸汽灭菌，取100 uL微生物溶液培养在琼脂培养皿上面，把放置在琼脂平板的表面中央。
步骤3：将样品置于在37ºC条件恒温培养箱培育 24小时，最后观察和测量抑菌圈。图3为壳聚糖/姜黄素纳米抗菌敷料对大肠杆菌产生的抗菌圈，抗菌圈直径在2 cm左右，表明壳聚糖/姜黄素纳米抗菌敷料具有很好的抗菌效果。

Claims (7)

1.一种静电纺制备壳聚糖/姜黄素纳米抗菌敷料的方法，包括：
（1）壳聚糖的配制：将壳聚糖在搅拌下缓慢加入到一定体积的溶剂中，搅拌至壳聚糖完全溶解，停止搅拌，超声处理15 min ，进行脱气，得到纺丝溶液；
（2）药物溶液的配制：将一定量的姜黄素加入到乙醇中，超声15分钟，至完全溶解；
（3）将步骤（2）的药物溶液全部加入步骤（1）的聚合物溶液，继续搅拌8-12小时，得到橙黄色的含有药物的聚合物溶液，超声处理15 min 进行脱气，得到纺丝溶液；
（4）采用上述的纺丝溶液进行静电纺丝，得到纳米抗菌敷料，最后真空干燥，即得。
2.根据权利要求1所述的一种静电纺制备壳聚糖/姜黄素纳米抗菌敷料的方法，其特征在于：步骤（1）所述的溶剂为质量浓度为80~90%的乙酸。
3.根据权利要求1所述的一种静电纺制备壳聚糖/姜黄素纳米抗菌敷料的方法，其特征在于：壳聚糖的质量浓度范围为2~8wt. %。
4.根据权利要求1所述的一种静电纺制备壳聚糖/姜黄素纳米抗菌敷料的方法，其特征在于：步骤（2）得到的药物溶液中姜黄素的质量浓度为1-5wt.%。
5.根据权利要求1所述的一种静电纺制备壳聚糖/姜黄素纳米抗菌敷料的方法，其特征在于：步骤（3）得到的纺丝溶液中，药物溶液和壳聚糖纺丝液的质量比在1：2~1：4。
6.根据权利要求1所述的一种静电纺制备壳聚糖/姜黄素纳米抗菌敷料的方法，其特征在于：步骤（4）所述的静电纺丝中注射器规格为5 mL，针头内径为0.4~0.7 mm，接收屏采用铝箔接地接收，针头与接收屏的距离为10～20 cm。
7.根据权利要求1所述的一种静电纺制备壳聚糖/姜黄素纳米抗菌敷料的方法，其特征在于：步骤（4）所述的静电纺丝过程中喷出流速为0.5～1.5 mL/h。
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108159485A (zh) * 2017-12-28 2018-06-15 广州贝奥吉因生物科技有限公司 一种负载姜黄素/明胶微球复合物的壳聚糖/丝素蛋白支架、其制备方法及其应用
CN109487439A (zh) * 2018-11-15 2019-03-19 无锡中科光远生物材料有限公司 一种黄原胶/壳聚糖纳米纤维膜的制备方法
CN109610094A (zh) * 2018-12-17 2019-04-12 浙江大学 多层静电纺丝食品包装膜及其制备方法
CN111249515A (zh) * 2020-03-11 2020-06-09 西安工程大学 抗菌消炎和促进伤口愈合的生物医用敷料及其制备方法
CN114917765A (zh) * 2022-05-20 2022-08-19 厦门大学 一种绒毛纳米纤维抗菌高效低阻空气过滤膜的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101638830A (zh) * 2009-08-25 2010-02-03 江南大学 一种纳米纤维膜的制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101638830A (zh) * 2009-08-25 2010-02-03 江南大学 一种纳米纤维膜的制备方法

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108159485A (zh) * 2017-12-28 2018-06-15 广州贝奥吉因生物科技有限公司 一种负载姜黄素/明胶微球复合物的壳聚糖/丝素蛋白支架、其制备方法及其应用
CN109487439A (zh) * 2018-11-15 2019-03-19 无锡中科光远生物材料有限公司 一种黄原胶/壳聚糖纳米纤维膜的制备方法
CN109610094A (zh) * 2018-12-17 2019-04-12 浙江大学 多层静电纺丝食品包装膜及其制备方法
CN111249515A (zh) * 2020-03-11 2020-06-09 西安工程大学 抗菌消炎和促进伤口愈合的生物医用敷料及其制备方法
CN114917765A (zh) * 2022-05-20 2022-08-19 厦门大学 一种绒毛纳米纤维抗菌高效低阻空气过滤膜的制备方法

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