CN107469198A - Improved mixing syringe assembly - Google Patents
Improved mixing syringe assembly Download PDFInfo
- Publication number
- CN107469198A CN107469198A CN201710780985.8A CN201710780985A CN107469198A CN 107469198 A CN107469198 A CN 107469198A CN 201710780985 A CN201710780985 A CN 201710780985A CN 107469198 A CN107469198 A CN 107469198A
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- China
- Prior art keywords
- plunger rod
- plug
- injector assembly
- volume
- axially
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- 239000012530 fluid Substances 0.000 claims abstract description 47
- 239000003814 drug Substances 0.000 claims abstract description 33
- 238000010276 construction Methods 0.000 claims abstract description 27
- 238000007789 sealing Methods 0.000 claims abstract description 15
- 230000007246 mechanism Effects 0.000 claims description 27
- 238000012856 packing Methods 0.000 claims description 23
- 239000000203 mixture Substances 0.000 description 16
- 230000002146 bilateral effect Effects 0.000 description 14
- 230000032258 transport Effects 0.000 description 10
- 238000002347 injection Methods 0.000 description 7
- 239000007924 injection Substances 0.000 description 7
- 238000004891 communication Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical class [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 230000000712 assembly Effects 0.000 description 2
- 238000000429 assembly Methods 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000004323 axial length Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M3/00—Medical syringes, e.g. enemata; Irrigators
- A61M3/005—Medical syringes, e.g. enemata; Irrigators comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M5/3137—Specially designed finger grip means, e.g. for easy manipulation of the syringe rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
- A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Package Specialized In Special Use (AREA)
Abstract
The application is related to improved mixing syringe assembly, including accommodates the cylinder of medicament, and cylinder has outlet to allow to discharge medicament；First plug, it moves axially in cylinder and defines the first volume of the first plug axially forward portion and the second volume of the first plug axially rear.First plug has two-way valve, and it is moved so that first and second volume to be connected between sealing and open configuration.Two-way valve moves on to open configuration by increasing the pressure of the first or second volume from seal construction.The second plug that injector assembly is additionally included in the first plug axially rear, moved axially in cylinder, it provides Fluid Sealing in the second volume rear end；The first plug, the first plunger rod extended axially rearward through the second plug are connected to, the second plug is sealingly engaged with the first plunger rod but allows the first plunger rod to be slid axially by the second plug.The axial movement of first plunger rod makes two-way valve move on to open configuration and fluidly connects the first and second volumes to move axially the first plug, the first or second volume of supercharging.
Description
The application is Application No. 201480018002.1, entitled " improved mixing syringe assembly ", application
Day is the divisional application of the application on March 26th, 2014.
The present invention relates to injector assembly, and more particularly, to being adapted to mix two or more medicines before conveying
The mixing syringe assembly equipped with valve of agent.
Background
It is known to provide the syringe with two or more chambers, and two or more chamber housings have in syringe
The different agents inside separated.Such device can be used for two or more medicaments are mixed before soon loading, if both or
Various medicaments are unstable (for example, in storage) when the long period being in admixture, then this is necessary.Mixing note
Emitter frequently includes the mechanism for making two or more dose chambers be in fluid communication with each other within the time of needs.
The example of the syringe of two chambers is described in WO-A-97/09839 (STI International Limited).Syringe bag
Include the two chambers separated by flexible wall member.A chamber housing before in chamber is dried in medicament, and chamber
A chamber housing liquid component below.Flexible wall component forming is so that when the wall member in device axially backward
During motion, the motion through the wall member of the liquid of the chamber below promotes the flexible wall member slight bending.This bending
Allow liquid component to bypass flexible wall member or spill around the periphery of flexible wall member and enter receiving to dry before medicament
Chamber in.
In at least one embodiment, it is an object of the invention to provide allow to mix the optional of two or more compositions
Injector assembly, wherein it is preferred to, at least one composition has sticking property.
The brief overview of the disclosure
According to the first aspect of the invention, there is provided a kind of injector assembly, including：
Cylinder, it is used to accommodate one or more medicaments, the cylinder have it is anterior export, front portion outlet allow described one kind or
Various medicaments are discharged through the outlet from the cylinder；
First plug, it is axially movable that it, which is arranged in this tin and in this tin, and is defined in cylinder
First volume of the axially forward portion of one plug and in cylinder the first plug axially rear the second volume, the first plug has
Two-way valve, the two-way valve be between seal construction and open configuration movably with optionally make the first volume and second hold
Product is in fluid communication, and the two-way valve can be from sealing by the increase of Fluid pressure in any one in the first volume and the second volume
Construction is moved to open configuration；
Second plug, it is arranged in the axially rear of the first plug in this tin and is axially removable in the cylinder
, the second plug provides fluid-tight seal in the rear end of the second volume；And
First plunger rod, it is connected to the first plug and extended axially rearward through the second plug, the second plug and
One plunger rod sealingly engages but allows the first plunger rod to be slid axially through the second plug；
Wherein, the first plunger rod is axially movable, so as to move axially the first plug and be pressurized the first volume and
Any one in second volume, hold so as to promote two-way valve to be moved to open configuration and fluidly connect the first volume and second
Product.
The injector assembly of the first aspect of the present invention is in response to the pressure in any one in first chamber and second chamber
Power increase, it is allowed to the fluid communication between first chamber and second chamber.Two-way valve when without or insufficient pressure act on
When thereon, (closure) construction of sealing is generally in.The fluid pressure of any one in the first volume and the second volume is increased
During power, two-way valve can move on to open configuration from seal construction.In practice it means that the first plug passes through the first plunger rod
Axial translation continuously axially forward and can move axially backward, to open two-way valve and effectively mixing is initially stored in the
Medicament in one volume and the second volume.It is this be arranged therein two kinds of medicaments be especially viscosity in the case of, for efficiently and
Effectively two kinds of medicaments of mixing are particularly suitable.The arrangement of known prior art does not allow the pressure increasing in response to any chamber
The fluid communication being added between adjacent chamber.As a result, the arrangement of known prior art do not allow plug it is continuous forward and
It is moved rearwards effective mixing of the composition to promote to be included in two chambers.
In a preferred embodiment, what injector assembly also included being configured to prevent the first plunger rod from moving axially can
The transport folder of removal.
First plunger rod can include being used to contribute to the one or more finger rings for operating the first plunger rod.
Injector assembly can also include the second plunger rod for being connected to the second plug, wherein, the axial direction of the second plunger rod
The mobile axial movement for causing the second plug.Alternatively, injector assembly also includes engaging mechanism, and the engaging mechanism is used for the
One plunger rod engages the first plunger rod and the second plunger rod in the precalculated position relative to the second plunger rod.Engaging mechanism can be with
Engagement member including being connected to the first plunger rod, the engagement member are arranged to when the first plunger rod is relative to the second plunger rod
Predetermined axial location and/or during rotation position, engaged with the second plunger rod.The engagement member can be from being connected to the first plunger
The sleeve of bar and circular second plunger rod radially-inwardly protrudes.The engagement member can be arranged to by adjoining second post
The rear end of stopper rod and engaged with the rear end of second plunger rod.
Injector assembly can also include the locking mechanism for being used to limit the axial movement of the second plunger rod.When the second plunger
When bar is in predetermined rotational positions, just the second plunger rod is allowed to move axially.Locking mechanism can include lasso, when the second plunger
When bar is in the predetermined rotational positions relative to lasso, it is allowed to which the second plunger rod moves axially, and lasso and the second plunger rod
Between axial direction adjoining prevent moving to axial in the rotation position in addition to predetermined rotational positions.
Two-way valve can be included in the elastic packing deformed under predetermined fluid pressure, wherein, the elastic packing can include
Multiple flexible flaps.The elastic packing can extend along the circular arc around the first plug, wherein, the angular region of circular arc is less than
360°。
First plug can include elastic packing and also include axially-spaced with elastic packing around the first plug
The permanent seal of excircle, and bypass channel, the bypass channel provide surrounding between the elastic packing and permanent seal
The fluid passage of permanent seal.
The fluid-tight seal provided by the second plug can be the sealing on sterile sealing and/or microbiology.
The application is related to herein below：
1) a kind of injector assembly, including：
Cylinder, it is used to accommodate one or more medicaments, and the cylinder has anterior outlet, for allowing the one or more
Medicament is discharged through the outlet from the cylinder；
First plug, it is arranged in the cylinder and is axially movable in the cylinder, and is defined in institute
State the of the first volume of the axially forward portion of the first plug described in cylinder and the axially rear of the first plug described in the cylinder
Two volumes, first plug have a two-way valve, the two-way valve be between seal construction and open configuration movably with
First volume is connected with second volumetric fluid, the two-way valve by first volume and
The increase of Fluid pressure in any one in second volume and can move on to the open configuration from the seal construction；
Second plug, it is arranged in the axially rear of the first plug described in the cylinder and is axially in the cylinder
Movably, second plug provides fluid-tight seal in the rear end of second volume；And
First plunger rod, it is connected to first plug and extended axially rearward through second plug, described
Second plug sealingly engages with first plunger rod but allows first plunger rod through second plug axial direction
Slide；
Wherein, first plunger rod is axially movable, to move axially first plug and to be pressurized institute
Any one in the first volume and second volume is stated, so as to cause the two-way valve to be moved to the open configuration and flow
Connect first volume and second volume body.
2) injector assembly according to 1), in addition to removable transport are pressed from both sides, and the removable folder that transports constructs
Into the axial movement for preventing first plunger rod.
1) or 2) 3) injector assembly according to, wherein, first plunger rod includes being used to help to operate institute
State one or more finger rings of the first plunger rod.
4. according to any foregoing described injector assembly, in addition to the second plunger rod of second plug is connected to,
Wherein, the axial movement of second plunger rod causes the axial movement of second plug.
5) injector assembly according to 4), in addition to engaging mechanism, the engaging mechanism are used in first post
Stopper rod makes first plunger rod be engaged with second plunger rod in the precalculated position relative to second plunger rod.
6) injector assembly according to 5), wherein, the engaging mechanism includes being connected to first plunger rod
Engagement member, the engagement member are arranged to when first plunger rod is in the predetermined axial location relative to the second plunger rod
And/or during rotation position, engaged with second plunger rod.
7) injector assembly according to 6), wherein, the engagement member from be connected to first plunger rod and
Sleeve around second plunger rod radially-inwardly protrudes.
6) or 7) 8) injector assembly according to, wherein, the engagement member is arranged to by adjoining described second
The rear end of plunger rod and engaged with the rear end of second plunger rod.
Any one of 8) 9) according to 4) to the injector assembly described in, in addition to for limiting second plunger rod
The locking mechanism of axial movement.
10) injector assembly according to 9), wherein, when second plunger rod is in predetermined rotational positions, permit
Perhaps the axial movement of described second plunger rod.
11) injector assembly according to 10), wherein, the locking mechanism includes lasso, and works as second post
When stopper rod is in the predetermined rotational positions relative to the lasso, it is allowed to the axial movement of second plunger rod, and it is described
Axial direction adjoining between lasso and second plunger rod prevents the phase in the rotation position in addition to the predetermined rotational positions
To axial movement.
12) injector assembly according to any one of foregoing, wherein, the two-way valve is included in predetermined fluid pressure
The elastic packing deformed under power.
13) injector assembly according to 12), wherein, the elastic packing includes multiple flexible flaps.
12) or 13) 14) injector assembly according to, wherein, the elastic packing is along around first plug
Circular arc extends, wherein, the angular region of the circular arc is less than 360 °.
15) injector assembly according to 12), 13) or 14), wherein, it is close that first plug includes the elasticity
Envelope, and also include the permanent seal axially-spaced with the elastic packing of the excircle around first plug, and
Bypass channel, the bypass channel provide between the elastic packing and the permanent seal around the permanent seal
Fluid passage.
16) injector assembly according to any one of foregoing, wherein, the fluid tight provided by second plug
Sealing is sterile sealing.
17) according to any one of foregoing injector assembly, wherein, the fluid-tight provided by second plug
Sealing is the sealing on microbiology.
18) it is a kind of generally such as the injector assembly being described with reference to the accompanying figures herein above.
Brief Description Of Drawings
By reference to accompanying drawing, embodiment of the present invention will be further described below, in the accompanying drawings：
Figure 1A to Fig. 1 D be according to the viewgraph of cross-section of the injector assembly of embodiment of the present invention, wherein, Figure 1A shows
The injector assembly gone out before use, Figure 1B and Fig. 1 C show that injector assembly during mixing, and Fig. 1 D are shown
Injector assembly during conveying；
Fig. 2A to Fig. 2 E be according to the present invention optional embodiment injector assembly viewgraph of cross-section, wherein,
Fig. 2A shows the injector assembly before use, and Fig. 2 B and Fig. 2 C show injector assembly during mixing, and Fig. 2 D show
Injector assembly upon mixing and is before transporting gone out, and Fig. 2 E show the injector assembly during conveying；
Fig. 3 shows the rear view of injector assembly shown in fig. 2；
Fig. 4 shows the rear view of injector assembly shown in figure 2d；
Fig. 5 shows the transversal of the mechanism for the axial movement for being used for limiting the second plunger rod according to embodiment of the present invention
Face view；
Fig. 6 shows the detailed cross-section of the mechanism of Fig. 5 along Fig. 5 section C-C interceptions；
Fig. 7 shows the detailed view of the first plug of Figure 1A to Fig. 1 D and Fig. 2A to Fig. 2 E injector assembly；
Fig. 8 shows the example for optional first plug for being used for injector assembly according to embodiment of the present invention；
Fig. 9 shows the optional view of the first plug according to embodiment of the present invention；And
Figure 10 shows the detailed cross-section of the first plug of Fig. 9 along Fig. 9 section D-D interceptions.
Embodiment
Figure 1A to Fig. 1 D are the viewgraph of cross-section according to the injector assembly 10 of embodiment of the present invention.Figure 1A is shown
Injector assembly 10 before use.Before injector assembly 10 includes the cylinder 12 for accommodating medicament and discharged with permission medicament
Portion exports 12a.In the embodiment shown in Figure 1A to Fig. 1 D, front portion outlet 12a be provided be used for pierce through injection site and from
Cylinder 12 is transported to medicament on the pin 13 of the injection site.Cylinder 12 has open rearward end 12b and the flange 12c radially extended, and this is convex
Edge can aid in the manually operated of injector assembly 10.Generally axially dimension extends injector assembly 10, the axial dimension
It will hereinafter be cited to help to describe injector assembly 10 and its part.Specifically, axially forwardly direction 100a edges injection
The length of device 10 points to the front end (that is, pointing to injection site) that its Chinese medicine will discharge, and direction 100b is pointed to axially rearward
Opposite direction, as indicated in figure ia.Unless otherwise indicated, all references to front and back herein are respectively intended to mean axle
Forwards and axial rearward direction.
First plug 14 is arranged in cylinder 12 and movement axially therein.First plug 14 defines the first appearance in cylinder 12
Product 16, the first volume is in the axially front of the first plug 14, and the first plug 14 defines the second volume 18 in cylinder 12, and second
Axial rearward direction of the volume in the first plug 14.Each in first volume and the second volume 16,18 is adapted to receiving to be that
This different fluid medicament.
Second plug 20 is arranged in the axial rearward direction of the first plug 14 in cylinder 12, and after defining the axial direction of the second volume 18
Square limit (defining the axially front limit of the first volume 16 in the front portion of cylinder 12).As the first plug 14, the second plug 20 exists
It is axially movable in cylinder 12.Second plug 20 provides the fluid-tight seal behind the second volume 18 so that not from
The fluid of two volumes 18 can flow out from the open rearward end 12b of cylinder 12.
First plug 14 has the first plunger rod 22 for being connected to first plug, and first plunger rod passes through the second plug
20 extend axially rearward.Second plug 20 sealingly engages the first plunger rod, to seal the rear portion of the second volume 18, but allows
First plunger rod 22 slides axially through the second plug 20.Therefore, the second plug 20 is hermetically centered around the first plunger rod 22
Ring between the inner surface of outside and cylinder 12.First plunger rod 22 includes being used to contribute to the finger ring for operating the first plunger rod 22
22a.The axial movement of first plunger rod 22 causes axial movement of first plug 14 in cylinder 12.In optional embodiment
In, can not have set finger ring 22a, or help to operate the optional construction of the first plunger rod 22.
In the embodiment shown in Figure 1A to Fig. 1 D, the second plug 20 is provided with the second plunger rod 24, the second plunger rod
24 radially outwardly extend axially rearward in the first plunger rod 22 from the second plug 20.The axial movement of second plunger rod 24 is led
Cause axial movement of second plug 20 in cylinder 12.The axial length of first plunger rod 22 is longer than the second plunger rod 24 so that
The rear end (it includes finger ring 22a) of at least the first plunger rod is always exposed to behind the second plunger rod 24, but regardless of the first post
How is the relative position of the plunger rod 22 of stopper rod 24 and second.
First plug 14 includes bilateral valve portion 14a, and the bilateral valve portion is between seal construction and open configuration can
Mobile.In seal construction, the first volume 16 is fluidly sealed from the second volume 18 and opened, and in open configuration, first holds
Product 16 is fluidly connected to the second volume 18.By increasing the pressure axially forward or axially backward of the first plug 14, bilateral
Valve portion 14a can move on to open configuration from seal construction.When being arranged in as shown in Figure 1A in cylinder 12, the first volume 16 is first
The axially front of plug 16, and the second volume 18 is in the axial rearward direction of the first plug 14, therefore, in the first volume 16 or the second
The increase of pressure can cause bilateral valve portion 14a to move on to open configuration from seal construction in any one in volume 18.It is crucial
Ground, by increasing, both pressure, bilateral valve portion 14a can move on to opening structure from seal construction axially forward and axially backward
Make so that if fluid is present in the first volume and the second volume 16,18, the first plug 14 is in direction axially forward or axial direction
The axial movement of backward directions is by the increase of the Fluid pressure caused in one in the first volume and the second volume 16,18
(depending on moving direction), this, which would then result in bilateral valve portion 14a openings and fluidly connects the first volume and second, holds
Product 16,18.When acting on the dynamic balance axially forward and axially backward on the 14a of two-way valve part (if for example, the first plug
The static a period of time in cylinder 12 of son 14), bilateral valve portion 14a will be moved back into seal construction.
The operation of injector assembly 10 is described with reference to Figure 1B to Fig. 1 D.For start mixing be contained in the first volume and
Medicament in second volume 16,18, the first plug 14 continuously axially forward and move axially backward in cylinder 12, and the second plug
The remains stationary in cylinder 12 of son 20.To accomplish this point, the first plunger rod 22 axially forward and moves axially backward relative to cylinder 12,
And the second plunger rod 24 does not move relative to cylinder 12.
Figure 1B shows the first plug 14 moved axially backward and the first post compared with the construction shown in figure ia
Stopper rod 22.When being moved to the construction shown in fig. ib, the fluid in the second volume 18 will be increased in pressure wherein should
Increase causes bilateral valve portion 14a to be moved to open configuration and fluidly connects the degree of the second volume 18 and the first volume 16.
Due to the bigger pressure in the second volume 18, the fluid in the second volume 18 enters the first volume 16 through bilateral valve portion 14a
In.The flowing of this fluid allows the backward axial movement of the first plug 14, so as to cause the reduction and first of the second volume 18
The increase of volume 16.Once all fluids are allowed to enter common volume (for example, first volume 16), pass through translation first
Plunger rod 22, the first plug 14 can be moved axially forward again, to promote the mixing for the fluid previously isolated, such as Fig. 1 C institutes
Show.In fact, the first plug 14 axially forward and can be continuously moved axially backward to promote two kinds of fluids in cylinder 12
It is sufficiently mixed.When one or both of two kinds of fluids are special viscosity or when not mixing, it is such be sufficiently mixed be probably must
Need.When lacking this stirring, two kinds of fluids can keep unmixed, although presented in same volume 16,18.Although
In this way, in certain embodiments, it is probably enough that the single of the first plug 14, which is moved rearwards for being sufficiently mixed, so that after
Continuous continuous forwardly and rearwardly move is unnecessary.It may be noted that for some drugses, by continuously forwardly and rearwardly movement is led
The medicine stirring of cause is probably harmful, thus, it may be preferable to which ground is limited.
Once two kinds of fluids have been thoroughly mixed, the first plug 14 moves (by pulling the first post axially backward axially rearward
Stopper rod 22) to be merged with the second plug 20, therefore the second volume 18 be reduced to it is essentially a zero so that substantially all of mixed flow
Body is (now bigger) to be in the first volume 16.To be moved axially forward from the fluid of the first volume distribution mixing, the second plug 20
Move (by the second plunger rod 24 moved axially forward).This action causes both the first plug 14 and the second plug 20 in cylinder 12
It is interior moved axially forward and fluid-mixing is pressurizeed, therefore cause fluid-mixing to leave cylinder 12 via front portion outlet 12a and pin 13.
The optional injector assembly 10 ' according to embodiment of the present invention is shown in Fig. 2A to 2E.Fig. 2A to figure
2E injector assembly 10 ' above for the injector assembly described by Figure 1A to Fig. 1 D with sharing many common features.Figure
New or modification feature (') reference number expression that is new or having upper label in 2A to Fig. 2 E.Fig. 2A to Fig. 2 E injection
Device assembly 10 ' is operated with the mixing two fluids in the first volume and the second volume 16,18, as Figure 1A to Fig. 1 D syringe
What component was carried out.
The injector assembly 10 ' shown in Fig. 2A to Fig. 2 E has the radial direction of the injector assembly 10 than Figure 1A to Fig. 1 D
The big flange 12c ' radially extended of the flange of extension.However, any one in embodiment 10,10 ' can include any chi
The very little flange radially extended.The bigger flange 12c' radially extended can aid in more easily operating syringe component
10、10’。
Injector assembly 10 ' includes removable transport folder 15, and (removable transport folder may reside according to the present invention
Any embodiment in, including above-mentioned embodiment 10), when removable transport is clamped and fitted on injector assembly 10 '
When, the removable folder that transports prevents the axial movement of the first plunger rod 22, so as to for example when injector assembly transports before use
During with processing, the unexpected mixing between the first volume and the second volume 16,18 is prevented.It can prevent the first plunger to transport folder 15
Bar 22 relative to the axial movement of cylinder 12 any removable holder mechanism or clamping device.Via bearing or clamping, transport
Folder 15 can additionally prevent the axial movement of the second plunger rod 24.In alternative embodiments, outer packing or other parts
It is a part of can abut, intervene or clamp the first plunger rod 22 and/or the second plunger rod 24, to prevent plunger rod from using
Preceding respective axial movement.When intending to use the dose out powders of component 10 ', outer packing (or other parts) can remove, so as to
Allow the axial movement of the first plunger rod 22 and/or the second plunger rod 24.
First plunger rod 22 includes being used to contribute to (double) the finger ring 22a' for operating the first plunger rod 22.In Fig. 2A to Fig. 2 E
In in the embodiment that shows, the first plunger rod 22 is relative to the second plunger rod 24 and cylinder 12 around the vertical of injector assembly 10 '
Axle (that is, parallel to axial direction 100a, 100b injector assembly 10 ' central axis) be rotatable.Fig. 3 shows it
Middle injector assembly 10 ' is in when in the first construction from the rearview of the line A-A interceptions in Fig. 2A.As shown in figure 3, finger ring 22a '
Flange 12c ' perpendicular to cylinder 12 is directed.
In order to start to mix in injector assembly 10 ', (spy shown in fig. 2 must be removed first by transporting folder 15
Determine in embodiment).Once be removed, the first plunger rod 22 can axially forward and move axially backward with the first volume and
Fluid-mixing in second volume 16,18 (via the bilateral valve portion 14a of opening).Fig. 2 B show the note during mix stages
Emitter assemblies 10 ', wherein front ends of first plug 14 in cylinder.In fig. 2b, it can be seen that the first plunger rod 22 includes engagement
Mechanism, the engaging mechanism include the sleeve 23 extended axially forward from finger ring 22a '.Sleeve 23 has than the second plunger rod 24
The big diameter of diameter, to surround the second plunger rod 24.Engagement member 23a after sleeve 23 has one group, it radially-inwardly stretches out
And the rear end of adjacent second plunger rod 24 is to limit foremost position of first plunger rod 22 relative to the second plunger rod 24.In passing
One is carried, in the embodiment shown in fig. 2b, when rear joint element 23a abuts the second plunger rod 24, the first plunger rod
14 also foremost positions in cylinder 12.Therefore, the front end of cylinder 12, instead of rear joint element 23a or except rear joint element 23a
In addition, the front end axial location of the first plunger rod 22 can be limited.
When the fluid in the first volume 16 and the second volume 18 has been thoroughly mixed, the first plunger rod 22 moves axially backward
It is dynamic to move axially backward the first plug 14, until the first plug 14 and the second plug 20 can and, so that the second volume 18 be subtracted
It is small to about zero and to promote all fluid-mixing to enter in (increasing now) first volume 16.Fig. 2 C show syringe
Component 10 ', the first plug 14 withdraw so that it contacts the second plug 20 axially backward.
Second plunger rod 24 of the embodiment unlike described by above for Figure 1A to Fig. 1 D, Fig. 2A to Fig. 2 E implementation
Second plunger rod 24 of scheme does not have flange (24a).Therefore, in order to which the second plunger rod 24 moved axially forward is certain to convey
(mixing) medicament of dosage, the first plunger rod 22 must engage with the second plunger rod 24.In order to allow required engagement, the first post
The finger ring 22a ' of stopper rod 22 is rotated by 90 ° so that the flange 12c ' with cylinder 12 is aligned around the longitudinal axis.To accomplish this point, preceding engagement member
The rear end of 23b and the second plunger rod 24 enters alignment so that due to preceding engagement member 23b and the second plunger rod 24 rear end
Between adjoining, do not allow the first plunger rod 22 relative to the moved axially forward of the second plunger rod 24.Before above-mentioned alignment,
Preceding engagement member 23b can axially advance along the groove in the second plunger rod 24 or passage.Therefore, the axial direction of the first plunger rod 22
Forward movement causes the moved axially forward of the second plunger rod 24, and causes the content of the first volume 16 to be pressurized, so as to
The content is caused to be discharged by pin 13.Fig. 2 E show the note at the end of conveying when the entire contents of cylinder 12 have been distributed
Emitter assemblies 10 '.
Although sleeve 23 and preceding joint element and rear joint element 23b, 23a are represented for selectively engaging the first plunger
The exemplary of the suitable engagement device of the plunger rod 24 of bar 22 and second, but can adopt within the scope of the invention
With any suitable mechanism.The use of adjacent or clamping device mechanism is particularly suitable, and needs to rotate with engaged/disengaged
The mechanism of first plunger rod and the second plunger rod 22,24 is particularly preferred, because they reduce the risk of accidental engagement simultaneously
Provide a user the first plunger rod and what whether the second plunger rod 22,24 engaged is explicitly indicated.In fact, 90 ° of rotation is one
Individual preferable selection.Meanwhile above-mentioned embodiment is the first plunger rod 22 is engaged with the second plunger rod 24, it is necessary to the first post
90 ° of rotations of stopper rod 22, in the optional embodiment according to embodiment of the present invention, can use other angles.
In preferred embodiment, before such rotation is allowed, the first plunger rod 22 is by relative to the predetermined of the second plunger rod 24
Axial location.
Fig. 5, which is related to, may reside in any embodiment to limit the another of the unnecessary axial movement of the second plunger rod 24
Outer feature.In preferred embodiments, the other feature forms the syringe described by above for Fig. 2A to Fig. 2 E
A part for component 10 '.As shown in figure 5, lasso 30 is located at behind the flange 12c of syringe cylinder 12 and around the second of modification
Plunger rod 24' and the first plunger rod 22' of modification.Fig. 6 shows the sectional view along Fig. 5 section C-C, can from the figure
Go out, lasso 30 is typically circle, and has the first inner edge 30b and the second inner edge 30a, and both define center port together.The
Each in one inner edge and second inner edge 30b, 30a has circular contour, wherein, the name circle of the second inner edge 30a profile
Diameter more than the first inner edge 30b profile nominal diameter of a circle.As a result, the second inner edge 30a is by the first inner edge 30b circle
Notch (cut out portion) is provided in fixed other circular orifice.Figure 6 illustrates embodiment in, have two
Notch, wherein, each notch extends along circular arc, and each notch angularly separates with other notch.
In optional embodiment, other angled arrangements may is that possible.
On the contrary, the second plunger rod 24 ' has two notch, each notch is defined by inwall 24b '.Inwall 24b ' has
There is generally rounded profile, and the name circle of inwall 24b ' profile is with the straight of the outer wall 24c ' than the second plunger rod 24'
The small diameter in footpath.Figure 6 illustrates embodiment in, each inwall has an angular range, and each inwall 24b ' and its
Its inwall 24b ' is angularly separated.This angle arrangement is arranged corresponding to the angle of above-mentioned lasso 30.Optional real
Apply in scheme, other angles of the plunger rod 24 ' of lasso 30 and second arrangement may is that possible.In cross-section, the second plunger
The notch of bar 24 ' is defined in the protuberance radially extended between the notch.
Lasso 30 provides the certain angle for only allowing the second plunger rod 24 ' in the second plunger rod 24 ' relative to lasso 30
The locking mechanism moved axially in construction.Specifically, if outer wall 24c ' and the notch by the second inner edge 30a lassos defined
Axially align, then allow the axial movement of the second plunger rod 24 '.
In specific preferred embodiment, the first plunger rod 22 ' just begins axially to move independently of the second plunger rod 24 '
It is dynamic, so as to realize above-mentioned mixing.Simultaneously the second plunger rod 24 ' due to the second plunger rod 24 ' outer wall 24c ' with by the
The notch axial misalignment for the lasso that two inner edge 30a are defined, axially limited by lasso 30.Once complete mixing, the first plunger
Bar 22 ' can surround its longitudinal axis and rotate, so as to by the axial lock of the first plunger rod 22 ' to the second plunger rod 24 '.This can be with
Such as realized by above-mentioned sleeve 23 and engagement member 23a, 23b.First plunger rod 22' is relative to the second plunger rod 24'
Around further rotating for longitudinal axis the rotation between the first plunger rod 22 ' and the second plunger rod 24' can be caused to engage.This
The spline interface between the first plunger rod 22 ' and the second plunger rod 24', or the first plunger rod 22 ' and second can for example be passed through
Other angle relies on mechanism (angularly dependent mechanism) or construction to realize between plunger rod 24'.By
Rotatable engagement between the first plunger rod 22 ' and the second plunger rod 24 ', the first plunger rod 22 ' enter around longitudinal axis
One step, which rotates, causes the rotation of the second plunger rod 24 ', so as to cause the second plunger rod 24' outer wall 24c ' be moved to by second
The notch for the lasso 30 that inner edge 30a is defined axially aligns.In this position, the axial movement of the second plunger rod 24 ' is possible
So that the axial movement of the first plunger rod 22 ' causes the axial movement of the second plunger rod 24 '.
In preferred embodiments, it is necessary to which the first plunger rod 22 ' is rotated about longitudinal axes 45 ° with by the first plunger rod
22 ' are axially locked to the second plunger rod 24 ', and need the first plunger rod 22 ' to rotate 45 ° again around longitudinal axis with by the
The alignment to axial that two plunger rods 24 ' (it is then engaged with the first plunger rod 22' rotations) are rotated to wherein with lasso 30 is permitted
Perhaps the rotation position of the second plunger rod 24 ' axial movement.However, in alternative embodiments, any other suitable angle
Axial and rotation the engagement between the first plunger rod 22 ' and the second plunger rod 24 ' can be defined.
In one embodiment, the component can be disposed therein both the first plunger rod and the second plunger rod in cylinder
In the construction that cannot all move axially.First rotation (for example, the first plunger rod is relative to second plunger rod) can should
Component moves into the first plunger rod and can moved axially relative to the second plunger rod to allow in the construction of mixing.With
One rotation may or may not can by the first plunger lever shaft in the second rotation (for example, first plunger rod) of equidirectional
The second plunger rod is locked to ground.3rd rotation (for example, common rotation of the first plunger rod and the second plunger rod) can unlock
Second plunger rod, to allow the second plunger rod (and therefore first plunger rod) to move axially and to convey the medicament of doses.
In any embodiment according to the present invention, injector assembly 10,10 ' can include or can not include pin
13.For example, another giver (or not having giver completely) can be provided to contribute to confection to reach injection or conveying
Position passes through.The injector assembly of the present invention can be such as nose, eye, mouth, ear medicament delivery device or for by certain agent
The confection of amount is transported to other medicament delivery devices of patient and is not limited to pin class syringe.Giver such as pin
13 relative to injector assembly 10,10 ' can be attachable so that medicament can be mixed as closed system, hereafter, be applied
Medicine device can be attached to injector assembly 10,10 ' to give mixed medicament to injection site.Alternatively, the system of closing
It can be realized during mixing by the pin 13 that is blocked, is capped or otherwise seal or other givers.For example,
Pin 13 can be fixed initially (staked) in needle housing with stake, and so be kept during two kinds of compositions mix.Then, one
These compositions of denier are mixed into gratifying degree, and needle housing (or other blockings, capping or sealing device) can be removed to permit
Perhaps mixed composition is distributed.
Figure 7 illustrates the detailed view of the first plug 14.First plug 14 includes being used to receive and engage the first post
The back-oriented bracket 14b of stopper rod 22.The bracket can be screw thread bracket or only recess, into the recess, the first post
Stopper rod 22 can be fixed to the first plug (for example, by adhesive or friction).In fact, the first plug 14 can pass through friction
Coordinate or interference fit (for example, ball-and-socket joint) is attached to the first plunger rod 22.Importantly, the first plug 14 and the first plunger
Cooperation between bar 22 provides the positive engagement in the both direction of forwardly and rearwardly axial direction therebetween
(positive engagement), ensure that the first plug 14 is attached in cylinder 12 during using and (that is, mixing)
First plunger rod 22.In one example, when being assembled in the outside of cylinder 12, the first plug 14 only can loosely be bonded on first
On plunger rod 22, and when in the first plug 14 and the insertion tube 12 of the first plunger rod 22, cylinder 12 acts on the first plug 14
On friction can be used for the reliable fit established between the first plug 14 and the first plunger rod 22.Bilateral valve portion 14a includes
Multiple flexible flaps, its extension of side along the first plug 14 simultaneously form elastic packing with the inner surface of cylinder 12.Flap 14a is in foot
Deformed under enough Fluid pressures, to allow passing through for the fluid between the front and back of the first plug 14.Elastic packing
14a can extend (as shown in Figure 7) (and with angular range less than 360 °) along the side of the first plug 14 or they can
To surround whole first plug 14 (that is, the angular range with 360 °), as long as they are enough firmly to prevent unexpected opening, also
Want sufficiently flexible to open when needed.In alternative embodiments, elastic packing 14a can pass through the sheet of the first plug 14
Body is formed, so that elastic packing 14a is sealed in seal construction against self seal, rather than against cylinder 12.
Fig. 9 shows that another view of the first plug 14, and Figure 10 show the detailed view of the section D-D in Fig. 9.
From Fig. 9, it can be seen that the circular arc that the angle of first plugs 14 of the flexible flap 14a along circle is θ extends.θ amplitude will be to losing
Speed and efficiency has an impact by mistake.For example, be axially displaced in response to the first plug 14 in the volume 16,18 of receiving fluid,
According to the conservation of mass, small θ (or small bilateral valve portion 14a otherwise) will cause rapid flow of fluid.This stream
Dynamic optimization is by the mixing for optimizing these compositions and will realize that both power and time needed for expectation mixing are minimized.
Figure 8 illustrates the optional embodiment of the first plug 14 ' according to the present invention.First plug 14' includes
For receiving and engaging the back-oriented bracket 14b of the first plunger rod 22.In addition, the bracket can be screw thread bracket or only
It is recess, into the recess, the first plunger rod 22 can be fixed to the first plug 14 (for example, by adhesive or friction), or
Can be any other suitable attachment means for being used to be connected to the first plunger rod 22 as discussed above.Bilateral valve portion
14a ' is provided by the multiple flexible flaps for surrounding the axial cross section of the first plug 14 '.In addition, the first plug 14 ' is including permanent close
14c ' is sealed, its first plug 14 ' of encirclement is simultaneously axially-spaced from flexible flap 14a '.Permanent seal 14c ' is configured to against cylinder 12
Inner sealing and it is insufficient deformation with formed cross over the sealing fluid path.First plug 14 ' comprises additionally in bypass channel
14d ', bypass channel 14d ' are from the axial external surface between flap 14a' and permanent seal 14c' of the first plug 14 ' to
The preceding surface of one plug 14 ' is passed through, therefore bypasses permanent seal 14d '.Fluid can advance along bypass channel 14d ' so that folding
Wing 14a ' can run into the Fluid pressure from either side (front and rear) and deformation, so that bilateral valve portion 14a ' is changed into
The construction of opening.In alternative embodiments, flap 14a ' can not extend around the first plug 14' whole circumference.
In such embodiment, permanent seal in addition may be constructed remaining circumference.Alternatively, figure 8 illustrates embodiment
It can overturn so that axial rearwards of the permanent seal 14c ' in elastic packing 14a '.Under any circumstance, bypass channel 14d ' should
When around permanent seal 14c '.When around permanent seal 14c ', passage 14d ' introduces radial flow direction, and it provides flowing
The easier control of flowing velocity of fluid.
In any embodiment, any suitable two-way valve can be used, as long as the two-way valve increases from either side
During Fluid pressure, open configuration can be moved to from seal construction.In any embodiment, two-way valve, which can be provided with, promotes fluid
In turbulent flow pass through the hole of two-way valve or other constructions (for example, nozzle).Such arrangement can improve the mixing of these compositions.
Although injector assembly 10,10 ' has been described as including two kinds of fluid compositions, according to some implementations of the present invention
Scheme, injector assembly 10,10 ' can include dry composition (for example, powder or lyophilized composition) and humidity, fluid into
Point.In it the embodiment of dry ingredient be present, the first plug 14 must be first moved in the volume 16,18 for accommodating fluid composition
(that is, moving axially to reduce its volume), to promote the first plug 14 to move on in open configuration and to allow the moist sum of mixing
Dry composition.Once two volumes 16,18 accommodate liquid, the first plug 14 can as described above axially forwardly direction or to
Either one in axial direction moves up afterwards.The stirring provided by mobile first plug 14 can according to initially separate into
Point/characteristic of medicament produces such as latex, solution or suspension.Before use, and in assembling injector assembly 10,10' phases
Between, the both sides for the first plug 14 that these compositions can be introduced in cylinder 12 are (for example, respectively via front portion outlet 12a and after-opening
Hold 12b), to prevent cross pollution.
In certain embodiments, the component may be arranged so that only the second volume 18 accommodates medicament and first holds
Product 16 can be sky, or be generally zero volume (but, in practice, it is likely that in the anterior outlet of the first plug 14 and cylinder
Between will retain a small amount of volume space).In alternative embodiments, the component may be arranged so that only the first volume
16 to accommodate medicaments and the second volume 18 can be sky, or be generally zero volume (furthermore in practice, it is likely that first
A small amount of volume space will be retained between the plug 20 of plug 14 and second).
Through the described and claimed of this specification, term " comprising " and "comprising" and its variant mean " including but
It is not limited to ", and be not intended as (no) and exclude other parts, additive, part, integer or step.Through retouching for this specification
State and claim, odd number include plural number, unless the context requires otherwise.Specifically, when using indefinite article, it should be understood that this
Specification is in view of multiple and single, unless the context requires otherwise.
Feature, integer with reference to described by certain aspects of the present disclosure, embodiment or example, characteristic, compound, chemistry
Part or group be interpreted as can be applied to any other aspect, embodiment or example as described herein, unless with this aspect,
Embodiment or example are incompatible.Disclosed in this manual all features (including any appended claims, summary and attached
Figure) and/or all steps of disclosed any method or process can be combined in any combinations, except at least some of such
Beyond feature and/or step are mutually exclusive.The present invention is not limited by the details of any foregoing embodiments.The present invention expands to
Disclose in this manual feature any novel feature or any novel combination (including any appended claims, summary and
Accompanying drawing), or any novel step of the step of disclosed any method or process or any novel combination.
The attention of reader is directed into and this specification while submission or the institute relevant with the application submitted before this
There are paper and document, these papers and document open to the public for consulting, and the content of all such papers and document passes through
It is incorporated herein by reference.
Claims (18)
1. a kind of injector assembly, including：
Cylinder, it is used to accommodate one or more medicaments, and the cylinder has anterior outlet, for allowing one or more medicaments
Discharged through the outlet from the cylinder；
First plug, it is arranged in the cylinder and is axially movable in the cylinder, and is defined in the cylinder
Described in the first plug axially forward portion the first volume and the axially rear of the first plug described in the cylinder second hold
Product, first plug have two-way valve, and the two-way valve is movably with selection between seal construction and open configuration
Property first volume is set to be connected with second volumetric fluid, the two-way valve passes through in first volume and described
The increase of Fluid pressure in any one in second volume and can move on to the open configuration from the seal construction；
Second plug, it is arranged in the axially rear of the first plug described in the cylinder and is axially removable in the cylinder
Dynamic, second plug provides fluid-tight seal in the rear end of second volume；And
First plunger rod, it is connected to first plug and extended axially rearward through second plug, described second
Plug sealingly engages with first plunger rod but allows first plunger rod to be slid axially through second plug；
Wherein, first plunger rod is axially movable, to move axially first plug and to be pressurized described
Any one in one volume and second volume, so as to cause the two-way valve to be moved to the open configuration and fluidly
Connect first volume and second volume.
2. injector assembly according to claim 1, in addition to removable transport are pressed from both sides, removable transport presss from both sides structure
Cause to prevent the axial movement of first plunger rod.
3. injector assembly according to claim 1 or 2, wherein, first plunger rod includes being used to help to operate
One or more finger rings of first plunger rod.
4. according to the injector assembly described in any preceding claims, in addition to it is connected to the second plunger of second plug
Bar, wherein, the axial movement of second plunger rod causes the axial movement of second plug.
5. injector assembly according to claim 4, in addition to engaging mechanism, the engaging mechanism is used for described first
Plunger rod makes first plunger rod be engaged with second plunger rod in the precalculated position relative to second plunger rod.
6. injector assembly according to claim 5, wherein, the engaging mechanism includes being connected to first plunger rod
Engagement member, the engagement member be arranged to when first plunger rod in the predetermined axial location relative to the second plunger rod
And/or during rotation position, engaged with second plunger rod.
7. injector assembly according to claim 6, wherein, the engagement member is from being connected to first plunger rod simultaneously
And radially-inwardly protruded around the sleeve of second plunger rod.
8. the injector assembly according to claim 6 or 7, wherein, the engagement member is arranged to by adjoining described
The rear end of two plunger rods and engaged with the rear end of second plunger rod.
9. the injector assembly according to any one of claim 4 to 8, in addition to for limiting second plunger rod
Axial movement locking mechanism.
10. injector assembly according to claim 9, wherein, when second plunger rod is in predetermined rotational positions,
Allow the axial movement of second plunger rod.
11. injector assembly according to claim 10, wherein, the locking mechanism includes lasso, and when described the
When two plunger rods are in the predetermined rotational positions relative to the lasso, it is allowed to the axial movement of second plunger rod, and
Axial direction adjoining between the lasso and second plunger rod is prevented in the rotation position in addition to the predetermined rotational positions
Move to axial.
12. the injector assembly according to any one of preceding claims, wherein, the two-way valve is included in pre- constant current
The elastic packing deformed under body pressure.
13. injector assembly according to claim 12, wherein, the elastic packing includes multiple flexible flaps.
14. the injector assembly according to claim 12 or 13, wherein, the elastic packing edge surrounds first plug
Circular arc extension, wherein, the angular region of the circular arc is less than 360 °.
15. according to the injector assembly described in claim 12,13 or 14, wherein, it is close that first plug includes the elasticity
Envelope, and also include the permanent seal axially-spaced with the elastic packing of the excircle around first plug, and
Bypass channel, the bypass channel provide between the elastic packing and the permanent seal around the permanent seal
Fluid passage.
16. the injector assembly according to any one of preceding claims, wherein, the stream provided by second plug
Body tight seal is sterile sealing.
17. according to any one of preceding claims injector assembly, wherein, the fluid provided by second plug
Tight seal is the sealing on microbiology.
It is 18. a kind of generally such as the injector assembly being described with reference to the accompanying figures herein above.
Applications Claiming Priority (3)
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| GBGB1305489.5A GB201305489D0 (en) | 2013-03-26 | 2013-03-26 | Improved syringe assembly |
| GB1305489.5 | 2013-03-26 | ||
| CN201480018002.1A CN105142701A (en) | 2013-03-26 | 2014-03-26 | Improved mixing syringe assembly |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201480018002.1A Division CN105142701A (en) | 2013-03-26 | 2014-03-26 | Improved mixing syringe assembly |
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| CN107469198A true CN107469198A (en) | 2017-12-15 |
| CN107469198B CN107469198B (en) | 2020-09-18 |
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| CN201480018002.1A Pending CN105142701A (en) | 2013-03-26 | 2014-03-26 | Improved mixing syringe assembly |
| CN201710780985.8A Active CN107469198B (en) | 2013-03-26 | 2014-03-26 | Improved mixing syringe assembly |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480018002.1A Pending CN105142701A (en) | 2013-03-26 | 2014-03-26 | Improved mixing syringe assembly |
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| EP (1) | EP2978476B1 (en) |
| JP (1) | JP6714505B2 (en) |
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| MX (1) | MX2015013733A (en) |
| NI (1) | NI201500145A (en) |
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| US10483926B2 (en) | 2015-02-15 | 2019-11-19 | Skyworks Solutions, Inc. | Power amplifier module with power supply control |
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| CN109843355B (en) * | 2016-10-17 | 2022-03-25 | 拜耳医药保健有限公司 | Fluid injector with syringe engagement mechanism |
| KR101903682B1 (en) * | 2017-01-06 | 2018-10-05 | (주)엠큐어 | Injector of Gas and Drug |
| CN114904094B (en) * | 2018-05-15 | 2024-05-28 | 贝克顿·迪金森公司 | Syringe plunger stopper for high dose precision drug delivery |
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| KR102067941B1 (en) * | 2019-09-18 | 2020-01-20 | 송치훈 | Syringe assisting retraction of the plunger |
| CN115003262A (en) * | 2019-12-05 | 2022-09-02 | 豪夫迈·罗氏有限公司 | Syringe and tightness testing method |
| US11241330B1 (en) | 2021-04-02 | 2022-02-08 | Brixton Biosciences, Inc. | Apparatus for creation of injectable slurry |
| KR102361471B1 (en) * | 2021-08-17 | 2022-02-15 | 메디허브 주식회사 | Automatic syringe injecting a drug into a fixed quantity based on prescription information |
| KR102623503B1 (en) * | 2021-10-26 | 2024-01-11 | 메디허브 주식회사 | Prefield syringe, automatic syringe for the reading drug information from the prefield syringe |
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- 2014-03-26 ES ES14715078.3T patent/ES2670979T3/en active Active
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| CN109009166A (en) * | 2018-08-13 | 2018-12-18 | 王珍茹 | A kind of blood collector for physical examination |
| CN109171768A (en) * | 2018-08-13 | 2019-01-11 | 王珍茹 | A kind of physical examination blood letting device |
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