GB1214053A - Improvements in or relating to two chamber injection ampoules - Google Patents

Improvements in or relating to two chamber injection ampoules

Info

Publication number
GB1214053A
GB1214053A GB574468A GB574468A GB1214053A GB 1214053 A GB1214053 A GB 1214053A GB 574468 A GB574468 A GB 574468A GB 574468 A GB574468 A GB 574468A GB 1214053 A GB1214053 A GB 1214053A
Authority
GB
Grant status
Application
Patent type
Prior art keywords
piston
plunger
intermediate
ampoule
sealing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB574468A
Inventor
Hans Wimmer
Original Assignee
Hans Wimmer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F15/00Accessories for mixers ; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F15/02Feed or discharge mechanisms
    • B01F15/0201Feed mechanisms
    • B01F15/0205Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartiments or cartridges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F11/00Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F11/008Mixers with shaking, oscillating, or vibrating mechanisms the stirrers performing an oscillatory, vibratory or shaking movement
    • B01F11/0082Mixers with shaking, oscillating, or vibrating mechanisms the stirrers performing an oscillatory, vibratory or shaking movement performing a rectilinear reciprocating movement
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F13/00Other mixers; Mixing plant, including combinations of mixers, e.g. of dissimilar mixers
    • B01F13/0016Movable or transportable mixing devices or plants
    • B01F13/0018Movable mixing devices, i.e. apt to be shifted or displaced from one place to another, e.g. by human force
    • B01F13/002Movable mixing devices, i.e. apt to be shifted or displaced from one place to another, e.g. by human force portable during use, e.g. hand-held
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F13/00Other mixers; Mixing plant, including combinations of mixers, e.g. of dissimilar mixers
    • B01F13/0016Movable or transportable mixing devices or plants
    • B01F13/0018Movable mixing devices, i.e. apt to be shifted or displaced from one place to another, e.g. by human force
    • B01F13/002Movable mixing devices, i.e. apt to be shifted or displaced from one place to another, e.g. by human force portable during use, e.g. hand-held
    • B01F13/0023Of the syringe, cartridge type
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F15/00Accessories for mixers ; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F15/02Feed or discharge mechanisms
    • B01F15/0201Feed mechanisms
    • B01F15/0205Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartiments or cartridges
    • B01F15/0213Opening valves which close-off openings between compartments
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F15/00Accessories for mixers ; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F15/02Feed or discharge mechanisms
    • B01F15/0201Feed mechanisms
    • B01F15/0222Feed mechanisms characterized by the relative arrangement of the containers for feeding or mixing the components
    • B01F15/0223Feed mechanisms characterized by the relative arrangement of the containers for feeding or mixing the components the containers being connected coaxially before contacting the contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A61M2005/31598Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F15/00Accessories for mixers ; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F15/00435Drives, e.g. for reciprocating motion; Transmissions; Brakes; Couplings
    • B01F15/00487Nature of the drive
    • B01F15/00506Hand driven

Abstract

1,214,053. Two-compartment injection ampoules. H. WIMMER. 5 Feb., 1968, No. 5744/ 68. Heading A5R. Two-compartment injecton ampoules comprising an ampoule barrel adapted to receive an injection needle at one end, and having a resilient sealing piston at the other end and an intermediate piston which initially divides the ampoule into two compartments, the contents of which are mixed by moving the intermediate piston towards the sealing piston, and the ampoule contents are injected by urging both intermediate and sealing pistons down the ampoule, are characterised in having a plunger which moves the intermediate piston so that, on movement of the intermediate piston towards the sealing piston, a previously sealed channel is opened which connects the two compartments across the intermediate piston and, during injection, both pistons are movably connected and move together down the ampoule. In the embodiments illustrated in Figs. 1-10 (Figs. 2-10 not shown) the bore of the piston 103 and the plunger 106 fitting into it are so shaped that in the initial position they together constitute a seal between compartments 109 and 110 but movement of the plunger to urge the intermediate piston towards the sealing piston causes relative movement therebetween and a channel is opened between the thinner end portion 161 of the plunger and the piston, the abutment ridge 115 (which is channeled to allow passage of liquid) urging the piston in the correct direction. When the two pistons meet and mixing is complete, the sealing piston (and hence the intermediate piston also) are urged down the ampoule by means such as a shaped ridge 197 on the plunger cooperating with a groove of appropriate profile in the sealing piston (Figs. 1 to 5). Alternatively, an additional plunger fitted outside the plunger for the intermediate piston and acting on both the sealing piston and the inner plunger (Figs. 8, 9, 10 and 12) may be used. Figs. 12 and 13 (not shown) depict a device in which a duct 12a passes axially through the plunger 6a from a point 19 initially closed by the piston 3a but which opens into the upper compartment when the plunger first moves, the ridge 20 serving to hold the plunger and piston together with the duct open during subsequent movement of the plunger.
GB574468A 1968-02-05 1968-02-05 Improvements in or relating to two chamber injection ampoules Expired GB1214053A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB574468A GB1214053A (en) 1968-02-05 1968-02-05 Improvements in or relating to two chamber injection ampoules

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB574468A GB1214053A (en) 1968-02-05 1968-02-05 Improvements in or relating to two chamber injection ampoules

Publications (1)

Publication Number Publication Date
GB1214053A true true GB1214053A (en) 1970-12-02

Family

ID=9801839

Family Applications (1)

Application Number Title Priority Date Filing Date
GB574468A Expired GB1214053A (en) 1968-02-05 1968-02-05 Improvements in or relating to two chamber injection ampoules

Country Status (1)

Country Link
GB (1) GB1214053A (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985122A (en) * 1975-06-04 1976-10-12 Medical Development Corporation Multi-piston syringe device
WO1982000457A1 (en) * 1980-07-31 1982-02-18 Res & Chem Corp Prod Improved barrier two part pairing and dispensing cartridge
EP0082251A1 (en) * 1981-12-22 1983-06-29 Contraves Ag Syringe for two fluids
US4874381A (en) * 1988-02-16 1989-10-17 Arzheimittel Gmbh Apotheker Vetter & Co. Ravensburg Hypodermic syringe
US4994043A (en) * 1987-06-16 1991-02-19 Akzo N.V. Two compartment syringe
EP0440846A1 (en) * 1990-02-07 1991-08-14 Arzneimittel GmbH Apotheker Vetter & Co. Ravensburg Two-compartment syringe and application process
EP0652019A1 (en) * 1993-11-08 1995-05-10 Ferring Arzneimittel GmbH Mixing and administration syringe
GB2338428A (en) * 1998-06-19 1999-12-22 David Grant A syringe with an agitator whose shaft passes through a slidable dispensing plunger
WO2007095036A2 (en) * 2006-02-10 2007-08-23 Dow Global Technologies Inc. Retractable pin mixing sample forming device and method
WO2007116086A1 (en) * 2006-04-12 2007-10-18 Glaxosmithkline Biologicals S.A. Syringe with sequentially moving plunger flanges
CN102784426A (en) * 2011-05-16 2012-11-21 吴振文 Injector
CN103029913A (en) * 2011-09-30 2013-04-10 汤维哲 Double-dye container
GB2514891A (en) * 2013-03-26 2014-12-10 Consort Medical Plc Improved syringe assembly
WO2015009868A1 (en) * 2013-07-16 2015-01-22 Unitract Syringe Pty Ltd Syringes for repetitive mixing and delivery of injectables

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985122A (en) * 1975-06-04 1976-10-12 Medical Development Corporation Multi-piston syringe device
WO1982000457A1 (en) * 1980-07-31 1982-02-18 Res & Chem Corp Prod Improved barrier two part pairing and dispensing cartridge
US4371094A (en) * 1980-07-31 1983-02-01 Products Research & Chemical Corporation Barrier two part pairing and dispensing cartridge
EP0082251A1 (en) * 1981-12-22 1983-06-29 Contraves Ag Syringe for two fluids
US4465476A (en) * 1981-12-22 1984-08-14 Contraves Ag Injection syringe for injecting two liquids
US4994043A (en) * 1987-06-16 1991-02-19 Akzo N.V. Two compartment syringe
US4874381A (en) * 1988-02-16 1989-10-17 Arzheimittel Gmbh Apotheker Vetter & Co. Ravensburg Hypodermic syringe
EP0440846A1 (en) * 1990-02-07 1991-08-14 Arzneimittel GmbH Apotheker Vetter & Co. Ravensburg Two-compartment syringe and application process
EP0652019A1 (en) * 1993-11-08 1995-05-10 Ferring Arzneimittel GmbH Mixing and administration syringe
US5630800A (en) * 1993-11-08 1997-05-20 Ferring Arzneimettel Gmbh Injection syringe for the missing and application of injection substances
GB2338428A (en) * 1998-06-19 1999-12-22 David Grant A syringe with an agitator whose shaft passes through a slidable dispensing plunger
WO2007095036A2 (en) * 2006-02-10 2007-08-23 Dow Global Technologies Inc. Retractable pin mixing sample forming device and method
WO2007095036A3 (en) * 2006-02-10 2007-10-04 Mark Alan Barger Retractable pin mixing sample forming device and method
US8220985B2 (en) 2006-02-10 2012-07-17 Dow Global Technologies Llc Retractable pin mixing sample forming device
WO2007116086A1 (en) * 2006-04-12 2007-10-18 Glaxosmithkline Biologicals S.A. Syringe with sequentially moving plunger flanges
CN102784426A (en) * 2011-05-16 2012-11-21 吴振文 Injector
CN103029913A (en) * 2011-09-30 2013-04-10 汤维哲 Double-dye container
GB2514891A (en) * 2013-03-26 2014-12-10 Consort Medical Plc Improved syringe assembly
GB2514891B (en) * 2013-03-26 2015-06-24 Consort Medical Plc Improved syringe assembly
WO2015009868A1 (en) * 2013-07-16 2015-01-22 Unitract Syringe Pty Ltd Syringes for repetitive mixing and delivery of injectables
WO2015009871A1 (en) * 2013-07-16 2015-01-22 Unitract Syringe Pty Ltd Syringes for prefilled and fill-at-use mixing and drug delivery
WO2015009866A3 (en) * 2013-07-16 2015-04-30 Unitract Syringe Pty Ltd Syringes for sequential delivery of injectables
CN105530976A (en) * 2013-07-16 2016-04-27 尤尼特拉克特注射器公司 Syringes for sequential delivery of injectables
CN105592875A (en) * 2013-07-16 2016-05-18 尤尼特拉克特注射器公司 Syringes for prefilled and fill-at-use mixing and drug delivery
US9586008B2 (en) 2013-07-16 2017-03-07 Unitract Syringe Pty Ltd Syringes for sequential delivery of injectables
US9592343B2 (en) 2013-07-16 2017-03-14 Unitract Syringe Pty Ltd. Syringes for repetitive mixing and delivery of injectables
US9597454B2 (en) 2013-07-16 2017-03-21 Unitract Syringe Pty Ltd. Syringes for prefilled and fill-at-use mixing and drug delivery

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee