CN107469170A - A kind of wearable artificial kidney - Google Patents
A kind of wearable artificial kidney Download PDFInfo
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- CN107469170A CN107469170A CN201710908855.8A CN201710908855A CN107469170A CN 107469170 A CN107469170 A CN 107469170A CN 201710908855 A CN201710908855 A CN 201710908855A CN 107469170 A CN107469170 A CN 107469170A
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- dialyzer
- dialyzate
- blood
- dialysis
- housing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1623—Disposition or location of membranes relative to fluids
- A61M1/1627—Dialyser of the inside perfusion type, i.e. blood flow inside hollow membrane fibres or tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1678—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes intracorporal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
- A61M1/1696—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/08—Supports for equipment
- A61M2209/088—Supports for equipment on the body
Abstract
The invention discloses a kind of wearable artificial kidney, including haemodialysis component, in addition to wearable device, the haemodialysis component is installed on wearable device；The haemodialysis component includes blood pump, dialyzer, dialysis liquid pump and dialysis fluid container；The blood pump is connected by pipeline with dialyzer, and blood pump is used to provide the power for flowing through dialyzer for blood；In pipeline of the dialyzate series connection of pumps between dialysis fluid container and dialyzer, dialysis liquid pump is used to provide the power for flowing through dialyzer for dialyzate.This artificial kidney can be carried with by dialysis person, to realize that hemodialysis patient completes haemodialysis in daily work and life.
Description
Technical field
The present invention relates to technical field of medical instruments, more particularly to a kind of wearable artificial kidney.
Background technology
Haemodialysis (hemodialysis, HD) is one of acute or chronic renal failure kidneys of patients Replacement Therapy.
It by by internal blood drainage to external, through one by thousands of dialyzers formed to tens of thousands of hollow fibre pipes, dialysis
When blood by being flowed through in hollow fibre pipe, dialyzate carries out solute exchange by flowing through outside hollow fibre pipe, by disperse/convection current,
Reach and remove internal metabolic waste, maintain electrolyte and acid-base balance；Moisture excessive in vivo is removed simultaneously, and will be passed through net
The blood recovery of change is to internal.Wherein hollow fibre pipe is the semi-transparent membrane tube for being covered with micro aperture on a kind of tube wall, only molecule
The solute that diameter is less than micropore just can freely lead to.
In the prior art, it is necessary to which the patient for carrying out haemodialysis, which generally requires hospital, completes haemodialysis, and blood is saturating
The frequency of analysis is even as high as three-times-weekly, and the water consumption of single dialysis, at 150 liters or so, the time is 4-6 hours.It is therefore existing
There is hemodialysis patient in technology to carry out the special place of haemodialysis needs, having a strong impact on needs outgoing work or tourism blood saturating
Analyse the work and life of patient.
The content of the invention
Carrying out haemodialysis for hemodialysis patient in the prior art set forth above needs special place, has a strong impact on
The problem of needing outgoing work or the work and life of hemodialysis patient of travelling, the invention provides a kind of Worn type is artificial
Kidney, this artificial kidney can be carried with by dialysis person, to realize that hemodialysis patient completes blood in daily work and life
Dialysis.
A kind of wearable artificial kidney provided by the invention solves problem by following technical essential：A kind of Worn type is artificial
Kidney, including haemodialysis component, in addition to wearable device, the haemodialysis component are installed on wearable device；
The haemodialysis component includes blood pump, dialyzer, dialysis liquid pump and dialysis fluid container；
The blood pump is connected by pipeline with dialyzer, and blood pump is used to provide the power for flowing through dialyzer for blood；
In pipeline of the dialyzate series connection of pumps between dialysis fluid container and dialyzer, dialysis liquid pump is used to be dialyzate
The power for flowing through dialyzer is provided.
Specifically, above wearable device can use the wearable in the dress on human body of the forms such as waistband, mandarin jacket, knapsack
Put, in a manner of reaching by increasing wearable device with human contact's area, the comfortable of this artificial kidney is worn to improve human body
Property., so, can be by blood because waistband and mandarin jacket are respectively provided with the characteristics of covering people's bulk area is big when such as using waistband or mandarin jacket
Dialysis component is split as multiple modules according to function, as blood pump, dialyzer, dialysis liquid pump, dialysis fluid container are respectively used as a mould
Block, is fixed on the diverse location of wearable device, and the fluid passage between corresponding module is realized by pipeline, respective electric connection
Connected also through the electrical cable of softness, after wearable device is worn on human body, above modules are using human body in
The heart so, is fallen on human body or closer to human body center of gravity itself around human body annular branch by the center of gravity of this artificial kidney
Mode so that this artificial kidney has more preferable wear comfort.
In this programme, above wearable device is worn on the wearable device on human body as this artificial kidney, and above blood is saturating
Functional part of the component as processing blood is analysed, by such scheme, may be such that haemodialysis component can move with wearer,
Haemodialysis is completed in the daily life of wearer or the course of work so that when undergoing hemodialysis is not necessarily in spending specific
Jian Qu hospitals complete haemodialysis, are greatly improved the quality of the life of undergoing hemodialysis.
Further technical scheme is：
In the prior art, the dialyzate required for single blood dialysis is completed typically in 150L or so, to cause using this
During artificial kidney, user is unnecessary to carry substantial amounts of dialyzate, to mitigate the heavy burden burden of dialysis person, in addition to is used for dialyzate
The regenerating unit of regeneration,
Pipeline is additionally provided between dialyzate outlet and dialysis fluid container on dialyzer, the regenerating unit is series at dialysis
In pipeline on device between dialyzate outlet and dialysis fluid container；
Dialyzate entrance and dialyzate hold on pipeline, dialyzer on dialyzer between dialyzate outlet and dialysis fluid container
Pipeline, dialysis liquid pump, dialyzer, regenerating unit, dialysis fluid container between device collectively constitute what is circulated for dialyzate
Loop.In this programme, equivalent to completing the dialyzate exchanged with blood material in dialyzer finally by being dialysed on dialyzer
Liquid outlet is entered in dialysis fluid container after flowing through regenerating unit, and above regenerating unit is used to purify corresponding dialyzate to be allowed to
Reach the standard used next time, so, this artificial kidney user wears several litres of dialyzates, continuous by being carried out to these dialyzates
Recycle, wearer bear a heavy burden it is lighter in the case of so that these dialyzates can be used in completing whole dialysis procedure.
Above regenerating unit can use the multiple process tanks being sequentially connected in series, such as flow through the flowing of regenerating unit in dialyzate
On direction, chopped-off head process tank subsequently sets gradually active carbon adsorption column, immuno absorbence using the urease tank for being provided with urease
Post, zirconium hydroxide and zirconium phosphate tank, i.e., the urea in used dialyzate is decomposed by the urease first, subsequently in profit
Other toxic components in dialyzate are adsorbed with active carbon adsorption column, immunoabsorbent column, zirconium hydroxide and zirconium phosphate tank, reaches and keeps away
Exempt from the purpose that urea impacts to the adsorbing medium in subsequent treatment tank.
In this programme, above dialysis liquid pump can be used as the power source that entirely circulates of dialyzate participation, i.e., it is actually
Also it is a circulating pump.
For ease of removing the excessive moisture in blood, in addition to it is connected to the ultrafiltrate pump on dialyzer in dialyzate outlet.
As one kind in the case where reaching specific dialysis-effect, the less dialyzer scheme of required dialysis liquid measure, the dialysis
Device includes dialyzer housing, and being additionally provided with blood entry port interface, dialyzate discharge coupling, dialyzate entrance on dialyzer housing connects
Mouthful and blood discharge coupling, be additionally provided with dialysis tubing in dialyzer housing, in addition to the resistive portion being arranged in dialyzer housing,
The resistive portion is located at the outside of dialysis tubing, and resistive portion is between dialyzate discharge coupling and dialyzate ingress interface, institute
Resistive portion is stated to be used to increase the resistance that dialyzate flows through dialyzer；
The blood pump is connected by blood entry port interface with dialyzer；
The blood discharge coupling is used to connect the pipeline that blood is led back to human body；
The dialyzate ingress interface is used to connect dialysis liquid pump；
The dialyzate that the dialyzate discharge coupling is used to use by dialyzer discharges dialyzer.
Specifically, above blood entry port interface is used to connect the pipeline between blood pump and dialyzer, to draw into dialyzer
Enter pending blood；Above blood discharge coupling is used to connect the draining blood pipeline between dialyzer and human body；It is described
Analysis pipe uses hollow fibre pipe, and the dialysis tubing flows through as blood between blood entry port interface and blood discharge coupling
The pipeline of parser；Above dialyzate ingress interface and dialyzate discharge coupling are respectively used to connection and dialyzate are introduced into dialyzer
Pipeline and draw dialyzate pipeline.At work, pending blood flows through dialyzer, dialyzate to dialyzer by dialysis tubing
Dialyzer is flowed through by the outside of dialysis tubing, separated material is needed in blood under Brownian movement, through on dialysis tube wall
Micropore is entered in dialyzate, completes the separation of part harmful substance in blood, i.e., carries out mass exchange by disperse；Existing skill
Also there is the scheme for directly filling into dialyzate to blood before dialyzer processing by dialyzate system in art, that is, a displacement is set
Liquid pump, the dialyzate as displacement liquid is filled into the transducer potector between blood entry port interface and blood pump, then by saturating
Analysis liquid system suctions out a certain amount of liquid from dialysis tubing, reaches and carries out mass exchange by convection current.So, it is existing to pass through convection current
Carry out in the Dialysis scheme of mass exchange, it is necessary to increase filter and displacement liquid pump in the entire system.
In this programme, above resistive portion is to be arranged on dialyzate dialyzate between dialysis tubing and dialyzer housing to flow
In flow, by the flow resistance for increasing dialyzate in the flow so that part or all of dialyzate is under differential pressure through dialysis
Pipe is entered in blood flow, then again in existing dialyzate system in the presence of balance system so that in blood flow to
The outside of dialysis tubing flows out the liquid isometric with the above-mentioned dialyzate entered in blood flow, so, is worn in respective liquid
When crossing dialysis tube wall outflow dialysis tubing, the material in blood is under the power of forced convertion, it is easier to through dialysis tube wall,
So, it not only ensure that the small molecule being harmful in blood can be entered smoothly by blood and blood purification completed in dialyzate,
It is strong so as to reach as middle molecule toxins can be also entered in dialyzate through dialysis tubing so that the harmful substance that molecule is bigger
Change the purpose of haemodialysis effect.
The resistive portion is intended to increase the flow resistance of dialyzate in dialyzate flow between dialysis tubing and dialyzer housing,
As those skilled in the art, the implementation of above resistive portion can be subject to reality by way of being placed obstacles in corresponding flow
It is existing：Tamper such as is set in corresponding flow, to reduce the area of a certain section of circulation passage in corresponding flow, by external force
Dialyzer housing inwardly produces deformation, to reduce the area of a certain section of circulation passage in corresponding flow, change dialyzer housing
Shape, increase flow resistance to cause respective streams journey that there are more inflection points, deflection plate is set in corresponding flow, with logical
When crossing dialyzate and being flowed in corresponding flow, there are dialyzate more turns to reach increase flow resistance etc. in corresponding flow
Scheme.
To sum up, this programme is compared to the existing scheme that mass exchange is carried out by convection current, it is not necessary in whole dialysis system
Middle increase filter can be realized with displacement liquid pump completes mass exchange by way of convection current, i.e., this programme is more simple in structure
In the case of list, not only small molecule toxins can be by clear in blood, while middle molecule toxins can also be forced through dialysis
Pipe, so, may be such that haemodialysis reaches preferable effect；The dialyzer scheme that this programme provides, due to partly or entirely saturating
It is enough through dialysis tubing to analyse liquid energy, in the presence of forced convertion, can be reached preferably thoroughly using the dialyzate of less volume
Analyse effect；The dialyzer scheme that this programme provides, because part or all of dialyzate can pass through dialysis tubing, with forced convertion
Under effect, in the case of dialyzate equivalent, more preferable dialysis-effect can reach；The dialyzer scheme that this programme provides, due to
Dialyzate, which enters blood, to be needed through dialysis tubing, and blood before dialysis is directly entered by replacing liquid pump dialyzate compared to existing
Scheme, the security of this programme are more reliable.
The dialyzer provided using this programme, can be saturating by existing progress single in the case where reaching same dialysis purpose
Dialysate consumption amount is analysed by 150 as little as 2 liters or so of liftings.When this programme combines the scheme with regenerating unit, single is completed
Dialyzate required for dialysis procedure is reduced to 1 liter or so：Such as to ensure that it is enough saturating that dialysis liquid pump can provide for dialyzer
Analyse liquid to supply, the reliability service of whole system can be met when the weight of dialyzate is 5 liters in whole artificial kidney.
As the specific implementation of resistive portion, the resistive portion is the size reduction section on dialyzer housing.This realization
Mode can be on existing dialyzer housing, and in outside, the simple processing of work can obtain the required forced convertion that includes and purify blood
Dialyzer.
Because the existing hollow fiber conduit as dialysis tubing has specific ultrafiltrate coefficient, therefore can pass through under differential pressure
The dialysate flow that dialysis tubing is entered in blood has bottleneck, to enable this dialyzer to utilize disperse and convection current simultaneously
Mass exchange is carried out, also has between the size reduction section and dialysis tubing and is used for the gap that dialyzate passes through.Using this programme,
Circulation passage of the above gap as the dialyzate that blood purification is carried out by disperse principle, as reach required dialysis effect
Rate, when reaching maximum through dialysis tubing progress blood to carry out the dialysate flow of convection current mass exchange, it can also pass through increasing
The flow of the dialyzate in the gap is passed through greatly, to strengthen the flow for the dialyzate that blood purification is carried out by disperse principle, i.e.,
This programme disperse, convection current progress mass exchange can be carried out simultaneously.
The dialyzer housing is in the form of a column, and blood entry port interface is arranged on the difference of dialyzer housing with blood discharge coupling
End；
The both ends of the dialyzer housing are provided with tube sheet, and each tube sheet described in end dialyzer housing where it with dialysing
Manage as more, each dialysis tubing is installed between two tube sheets, and each dialysis tubing is the communicating pipe between two blood rooms；
Dialyzate discharge coupling and dialyzate ingress interface are arranged in the region between two tube sheets.In this programme, phase
When two pieces of tube sheets serve not only as dialysing the fixed plate of tube end more than, while the inner space of dialyzer housing is divided into bag
Include two blood rooms as described above and the dialysis working chamber between blood room, dialyzate discharge coupling and dialyzate ingress interface
Communicated with dialysis working chamber, resistive portion is in dialysis working chamber.
The dialyzate ingress interface is arranged on one end that blood discharge coupling is set on dialyzer housing, the dialyzate
Discharge coupling is arranged on one end that blood entry port interface is set on dialyzer housing.In this programme, by being connect to dialyzate entrance
Mouth, the position relationship of blood discharge coupling, dialyzate discharge coupling, blood entry port interface limit, and enter equivalent to dialyzate
Mouth both interface and blood discharge coupling are located at same one end of dialyzer housing, dialyzate discharge coupling, blood entry port interface two
Person is located at the other end of dialyzer housing, and so, between dialyzate ingress interface and resistive portion, dialyzate enters through dialysis tubing
While entering blood, in dialyzate system in the presence of balance system, the liquid of blood moderate is by dialyzate discharge coupling
Forced convertion flows out dialysis tubing and takes away the toxin in blood between resistive portion, now, because liquid passes through dialysis in blood
Pipe enters haemoconcentration in the dialysis tubing corresponding to the outside of dialysis tubing and, closer to blood entry port interface, is participating in the saturating of convection current
In the case that analysis liquid accumulated amount is consistent, because the concentration of blood in corresponding dialysis tubing pipeline section is bigger, more poison can be so taken away
Element, i.e., using this programme, along in dialysis tubing on the flow direction of blood, because elder generation is by sucking liquid in dialysis tubing, then to saturating
Feeding-in liquid in pipe is analysed, in the case of identical dialysis liquid measure, more preferable toxin elimination effect can be reached.
Because dialyzer housing is equivalent to for an internal pressure vessel, to cause dialyzer housing, stress is more preferable when in use,
The dialyzer housing is cylindrical；
The resistive portion is the undergauge section on dialyzer housing；
Flex point is additionally provided with the original position and final position of the undergauge section, part or all of dialysis tubing, it is each
Flex point on analysis pipe causes middle part of the dialysis tubing closer to dialyzer housing at undergauge fragment position.This programme is intended to so that institute
Stating undergauge section does not influence the laying quantity of dialysis tubing.When the cross section of dialyzer housing is circular, the dialysis tubing on the circle of section
Between each other can be by the way of uniform, when having dialysis tubing such as the center of section circle, the dialysis tubing in center need not be set
Put flex point, excentral dialysis tubing is in undergauge fragment position to center deviation.
To enable dialysis tubing to play preferable blood purification effect by disperse, between dialysis tubing and dialysis tubing, thoroughly
Gap is respectively provided between analysis pipe and dialyzer housing.
The invention has the advantages that：
In this programme, above wearable device is worn on the wearable device on human body as this artificial kidney, and above blood is saturating
Functional part of the component as processing blood is analysed, by such scheme, may be such that haemodialysis component can move with wearer,
Haemodialysis is completed in the daily life of wearer or the course of work so that when undergoing hemodialysis is not necessarily in spending specific
Jian Qu hospitals complete haemodialysis, are greatly improved the quality of the life of undergoing hemodialysis.
Brief description of the drawings
Fig. 1 is a kind of three-dimensional structure diagram of one specific embodiment of wearable artificial kidney of the present invention；
Fig. 2 is a kind of system topological figure of one specific embodiment of wearable artificial kidney of the present invention, wherein, accordingly
Pipeline upward arrow represents the flow direction of fluid in the pipeline；
Fig. 3 is the front sectional view of dialyzer in one specific embodiment of a kind of wearable artificial kidney of the present invention.
Reference in figure is followed successively by：1st, dialyzer housing, 2, resistive portion, 3, dialysis tubing, 4, tube sheet, 5, blood entry port
Interface, 6, dialyzate discharge coupling, 7, dialyzate ingress interface, 8, blood discharge coupling, 9, blood room, 10, wearable device,
11st, blood pump, 12, ultrafiltrate pump, 13, regenerating unit, 14, dialysis fluid container, 15, dialysis liquid pump.
Embodiment
With reference to embodiment, the present invention is described in further detail, but the present invention structure be not limited only to it is following
Embodiment.
Embodiment 1：
As shown in Figure 1 to Figure 3, a kind of wearable artificial kidney, including haemodialysis component, in addition to wearable device 10,
The haemodialysis component is installed on wearable device 10；
The haemodialysis component includes blood pump 11, dialyzer, dialysis liquid pump 15 and dialysis fluid container 14；
The blood pump 11 is connected by pipeline with dialyzer, and blood pump 11 is used to provide the power for flowing through dialyzer for blood；
The dialysis liquid pump 15 is connected in the pipeline between dialysis fluid container 14 and dialyzer, and dialysis liquid pump 15 is for being
Dialyzate provides the power for flowing through dialyzer.
Specifically, above wearable device 10 can use the wearable in the dress on human body of the forms such as waistband, mandarin jacket, knapsack
Put, in a manner of reaching by increasing wearable device 10 with human contact's area, relaxing for this artificial kidney is worn to improve human body
Adaptive., so, can be by blood because waistband and mandarin jacket are respectively provided with the characteristics of covering people's bulk area is big when such as using waistband or mandarin jacket
Liquid dialysis component is split as multiple modules according to function, as blood pump 11, dialyzer, dialysis liquid pump 15, dialysis fluid container 14 are respectively made
For a module, the diverse location of wearable device 10 is fixed on, the fluid passage between corresponding module is realized by pipeline, phase
It should be electrically connected and be connected also through the electrical cable of softness, after wearable device 10 is worn on human body, each mould of the above
Block centered on human body around human body annular branch, so, fallen by the center of gravity of this artificial kidney on human body or closer to
The mode of human body itself center of gravity so that this artificial kidney has more preferable wear comfort.
In this programme, above wearable device 10 is worn on the wearable device on human body, above blood as this artificial kidney
Component dialyse as the functional part for handling blood, by such scheme, may be such that haemodialysis component can move with wearer
It is dynamic, complete haemodialysis in the daily life of wearer or the course of work so that undergoing hemodialysis is specific not necessarily in spending
Time go to hospital to complete haemodialysis, be greatly improved the quality of the life of undergoing hemodialysis.
Embodiment 2：
As shown in Figure 1 to Figure 3, the present embodiment is further qualified on the basis of embodiment 1：In the prior art, complete
Dialyzate required for single blood dialysis is typically in 150L or so, and during to use this artificial kidney, user is unnecessary to be taken
With substantial amounts of dialyzate, to mitigate the heavy burden burden of dialysis person, in addition to it is used for the regenerating unit 13 of dialysate regeneration,
Pipeline is additionally provided between dialyzate outlet and dialysis fluid container 14 on dialyzer, the regenerating unit 13 is series at
In pipeline on dialyzer between dialyzate outlet and dialysis fluid container 14；
Dialyzate entrance and dialyzate on pipeline, dialyzer on dialyzer between dialyzate outlet and dialysis fluid container 14
Pipeline, dialysis liquid pump 15, dialyzer, regenerating unit 13, dialysis fluid container 14 between container 14 are collectively constituted for dialyzate
The loop circulated.In this programme, equivalent to completing the dialyzate exchanged with blood material in dialyzer finally by saturating
Dialyzate outlet is entered in dialysis fluid container 14 after flowing through regenerating unit 13 on parser, and above regenerating unit 13 is used to purify phase
The dialyzate answered is to make up to the standard that next time uses, and so, this artificial kidney user wears several litres of dialyzates, by this
A little dialyzates are constantly recycled, in the case where wearer's heavy burden is lighter so that these dialyzates can be used in
Into whole dialysis procedure.
Above regenerating unit 13 can use the multiple process tanks being sequentially connected in series, and the stream of regenerating unit 13 is such as flowed through in dialyzate
On dynamic direction, chopped-off head process tank subsequently sets gradually active carbon adsorption column, immune suction using the urease tank for being provided with urease
Attached column, zirconium hydroxide and zirconium phosphate tank, i.e., the urea in used dialyzate is decomposed by the urease first, subsequently existed
Other toxic components in dialyzate are adsorbed using active carbon adsorption column, immunoabsorbent column, zirconium hydroxide and zirconium phosphate tank, are reached
The purpose for avoiding urea from impacting the adsorbing medium in subsequent treatment tank.
In this programme, above dialysis liquid pump 15 can participate in the power source entirely circulated, i.e. its reality as dialyzate
On be also a circulating pump.
For ease of removing the excessive moisture in blood, in addition to it is connected to the ultrafiltrate pump on dialyzer in dialyzate outlet
12。
Embodiment 3：
As shown in Figure 1 to Figure 3, the present embodiment is made further on the basis of the technical scheme that embodiment 2 provides to this case
Limit, as one kind in the case where reaching specific dialysis-effect, the less dialyzer scheme of required dialysis liquid measure, the dialyzer bag
Dialyzer housing 1 is included, blood entry port interface 5, dialyzate discharge coupling 6, dialyzate entrance are additionally provided with dialyzer housing 1 and is connect
Mouthfuls 7 and blood discharge coupling 8, dialysis tubing 3 is additionally provided with dialyzer housing 1, in addition to the resistance being arranged in dialyzer housing 1
Stream portion 2, the resistive portion 2 is located at the outside of dialysis tubing 3, and resistive portion 2 is located at dialyzate discharge coupling 6 and connect with dialyzate entrance
Between mouth 7, the resistive portion 2 is used to increase the resistance that dialyzate flows through dialyzer；
The blood pump 11 is connected by blood entry port interface 5 with dialyzer；
The blood discharge coupling 8 is used to connect the pipeline that blood is led back to human body；
The dialyzate ingress interface 7 is used to connect dialysis liquid pump 15；
The dialyzate that the dialyzate discharge coupling 6 is used to use by dialyzer discharges dialyzer.
Specifically, above blood entry port interface 5 is used to connect the pipeline between blood pump 11 and dialyzer, with into dialyzer
Introduce pending blood；Above blood discharge coupling 8 is used to connect the draining blood pipeline between dialyzer and human body；It is described
Dialysis tubing more than 3 uses hollow fibre pipe, and the dialysis tubing 3 is as blood between blood entry port interface 5 and blood discharge coupling 8
Flow through the pipeline of dialyzer；Above dialyzate ingress interface 7 and dialyzate discharge coupling 6 are respectively used to connection and drawn into dialyzer
Enter the pipeline of dialyzate and draw the pipeline of dialyzate.At work, pending blood flows through dialysis to dialyzer by dialysis tubing 3
Device, dialyzate flow through dialyzer by the outside of dialysis tubing 3, and separated material is needed in blood under Brownian movement, through saturating
Micropore on the analysis wall of pipe 3 is entered in dialyzate, completes the separation of part harmful substance in blood, i.e., carries out material by disperse
Exchange；Also there is the scheme for directly filling into dialyzate to blood before dialyzer processing by dialyzate system in the prior art, i.e.,
One displacement liquid pump, the transducer potector that the dialyzate as displacement liquid is filled between blood entry port interface 5 and blood pump 11 are set
In, a certain amount of liquid is then being suctioned out from dialysis tubing 3 by dialyzate system, is reaching and carries out mass exchange by convection current.
So, it is necessary to increase filter and displacement liquid in the entire system in the existing Dialysis scheme that mass exchange is carried out by convection current
Pump.
In this programme, above resistive portion 2 is arranged on dialyzate and dialysed between dialysis tubing 3 and dialyzer housing 1 liquid stream
In dynamic flow, by the flow resistance for increasing dialyzate in the flow so that part or all of dialyzate passes through under differential pressure
Dialysis tubing 3 is entered in blood flow, then again in existing dialyzate system in the presence of balance system so that blood flow
The middle liquid isometric with the above-mentioned dialyzate entered in blood flow to the outside outflow of dialysis tubing 3, so, in corresponding liquid
When body is through the tube wall of dialysis tubing 3 outflow dialysis tubing 3, the material in blood is under the power of forced convertion, it is easier to through dialysis
The tube wall of pipe 3, so, it not only ensure that the small molecule being harmful in blood can be entered smoothly by blood and blood completed in dialyzate
Liquid purifies so that the bigger harmful substance of molecule, as middle molecule toxins can be also entered in dialyzate through dialysis tubing 3, from
And reach the purpose for strengthening haemodialysis effect.
The flowing that the resistive portion 2 is intended to increase dialyzate in dialyzate flow between dialysis tubing 3 and dialyzer housing 1 hinders
Power, as those skilled in the art, the implementation of above resistive portion 2 can be added by way of being placed obstacles in corresponding flow
To realize：Tamper such as is set in corresponding flow, to reduce the area of a certain section of circulation passage in corresponding flow, pass through external force
So that dialyzer housing 1 inwardly produces deformation, to reduce the area of a certain section of circulation passage in corresponding flow, change dialyzer shell
The shape of body 1, increase flow resistance to cause respective streams journey that there are more inflection points, baffling is set in corresponding flow
Plate, during being flowed by dialyzate in corresponding flow, dialyzate there are more turns to reach increase flows in corresponding flow
The schemes such as dynamic resistance.
To sum up, this programme is compared to the existing scheme that mass exchange is carried out by convection current, it is not necessary in whole dialysis system
Middle increase filter can be realized with displacement liquid pump completes mass exchange by way of convection current, i.e., this programme is more simple in structure
In the case of list, not only small molecule toxins can be by clear in blood, while middle molecule toxins can also be forced through dialysis
Pipe 3, so, it may be such that haemodialysis reaches preferable effect；The dialyzer scheme that this programme provides, due to partly or entirely saturating
It is enough through dialysis tubing 3 to analyse liquid energy, in the presence of forced convertion, can be reached preferably thoroughly using the dialyzate of less volume
Analyse effect；The dialyzer scheme that this programme provides, because part or all of dialyzate can pass through dialysis tubing 3, with forced convertion
In the presence of, in the case of dialyzate equivalent, it can reach more preferable dialysis-effect；The dialyzer scheme that this programme provides, by
In dialyzate enter blood need through dialysis tubing 3, compared to it is existing by replace liquid pump dialyzate be directly entered dialysis before blood
The scheme of liquid, the security of this programme are more reliable.
The dialyzer provided using this programme, can be saturating by existing progress single in the case where reaching same dialysis purpose
Dialysate consumption amount is analysed by 150 as little as 2 liters or so of liftings.When this programme combines the scheme with regenerating unit 13, complete single
Dialyzate required for secondary dialysis procedure is less：Such as supplied to ensure that dialysis liquid pump 15 can provide enough dialyzates for dialyzer
Answer, the reliability service of whole system can be met when the weight of dialyzate is 5 liters in whole artificial kidney.
As the specific implementation of resistive portion 2, the resistive portion 2 is the size reduction section on dialyzer housing 1.This reality
Existing mode can be made simple processing and can obtain required to include forced convertion purified blood on existing dialyzer housing 1 outside
The dialyzer of liquid.
Because the existing hollow fiber conduit as dialysis tubing 3 has specific ultrafiltrate coefficient, therefore can wear under differential pressure
Crossing the dialysate flow that dialysis tubing 3 is entered in blood has bottleneck, for enable this dialyzer simultaneously using disperse and
Convection current carries out mass exchange, also has between the size reduction section and dialysis tubing 3 and is used for the gap that dialyzate passes through.Using this
Scheme, circulation passage of the above gap as the dialyzate that blood purification is carried out by disperse principle, required by as reaching
Dialytic efficiency, when reaching maximum through the progress blood of dialysis tubing 3 to carry out the dialysate flow of convection current mass exchange, also may be used
By increasing the flow through the dialyzate in the gap, to strengthen the stream for the dialyzate that blood purification is carried out by disperse principle
Amount, i.e. this programme disperse, convection current progress mass exchange can be carried out simultaneously.
The dialyzer housing 1 is in the form of a column, and blood entry port interface 5 is arranged on dialyzer housing 1 with blood discharge coupling 8
Different ends；
The both ends of the dialyzer housing 1 are provided with tube sheet 4, each tube sheet 4 with described in end dialyzer housing 1 where it
Dialysis tubing 3 is more, and each dialysis tubing 3 is installed between two tube sheets 4, and each dialysis tubing 3 is the connection between two blood rooms 9
Pipe；
Dialyzate discharge coupling 6 and dialyzate ingress interface 7 are arranged in the region between two tube sheets 4.In this programme,
Two pieces of tube sheets 4 serve not only as the fixed plate of the end of dialysis tubing 3 equivalent to more than, while the inner space of dialyzer housing 1 is divided
It is segmented into including two blood rooms 9 as described above and the dialysis working chamber between blood room 9, dialyzate discharge coupling 6 and dialysis
Liquid ingress interface 7 communicates with dialysis working chamber, and resistive portion 2 is in dialysis working chamber.
The dialyzate ingress interface 7 is arranged on one end that blood discharge coupling 8 is set on dialyzer housing 1, described
Analysis liquid discharge coupling 6 is arranged on one end that blood entry port interface 5 is set on dialyzer housing 1.In this programme, by dialyzate
Ingress interface 7, blood discharge coupling 8, dialyzate discharge coupling 6, the position relationship of blood entry port interface 5 four limit, quite
In dialyzate ingress interface 7 and blood discharge coupling 8, both are located at same one end of dialyzer housing 1, dialyzate discharge coupling 6,
Both are located at the other end of dialyzer housing 1 to blood entry port interface 5, so, between dialyzate ingress interface 7 and resistive portion 2,
While dialyzate is through dialysis tubing 3 into blood, in dialyzate system in the presence of balance system, the liquid of blood moderate
Body flows out dialysis tubing 3 by forced convertion between dialyzate discharge coupling 6 and resistive portion 2 and takes away the toxin in blood, now, by
Liquid enters in the dialysis tubing 3 corresponding to the outside of dialysis tubing 3 haemoconcentration closer to blood through dialysis tubing 3 in blood
Ingress interface 5, in the case where the dialysis liquid accumulated amount for participating in convection current is consistent, due in the corresponding pipeline section of dialysis tubing 3 blood it is dense
Degree is bigger, can so take away more toxin, i.e., using this programme, along in dialysis tubing 3 on the flow direction of blood, due to elder generation
By sucking liquid in dialysis tubing 3, then the feeding-in liquid into dialysis tubing 3, in the case of identical dialysis liquid measure, can reach more preferable
Toxin elimination effect.
Because dialyzer housing 1 is equivalent to for an internal pressure vessel, to cause dialyzer housing 1, stress is more when in use
Good, the dialyzer housing 1 is cylindrical；
The resistive portion 2 is the undergauge section on dialyzer housing 1；
Flex point is additionally provided with the original position and final position of the undergauge section, part or all of dialysis tubing 3, it is each
Flex point on analysis pipe 3 causes the dialysis tubing 3 at undergauge fragment position closer to the middle part of dialyzer housing 1.This programme is intended to make
Obtaining the undergauge section does not influence the laying quantity of dialysis tubing 3.When the cross section of dialyzer housing 1 is circular, on the circle of section
Dialysis tubing 3 between each other can be by the way of uniform, when having dialysis tubing 3 such as the center of section circle, the dialysis tubing 3 in center
Flex point need not be set, and excentral dialysis tubing 3 is in undergauge fragment position to center deviation.
To enable dialysis tubing 3 to play preferable blood purification effect by disperse, between dialysis tubing 3 and dialysis tubing 3,
Gap is respectively provided between dialysis tubing 3 and dialyzer housing 1.
Above content is to combine the further description that specific preferred embodiment is made to the present invention, it is impossible to assert this
The embodiment of invention is confined to these explanations.For general technical staff of the technical field of the invention,
The other embodiment drawn in the case where not departing from technical scheme, should be included within the scope of the present invention.
Claims (10)
1. a kind of wearable artificial kidney, including haemodialysis component, it is characterised in that described also including wearable device (10)
Haemodialysis component is installed on wearable device (10)；
The haemodialysis component includes blood pump (11), dialyzer, dialysis liquid pump (15) and dialysis fluid container (14)；
The blood pump (11) is connected by pipeline with dialyzer, and blood pump (11) is used to provide the power for flowing through dialyzer for blood；
The dialysis liquid pump (15) is connected in pipeline of the dialysis fluid container (14) between dialyzer, and dialysis liquid pump (15) is used for
The power for flowing through dialyzer is provided for dialyzate.
2. a kind of wearable artificial kidney according to claim 1, it is characterised in that also include being used for dialysate regeneration again
Generating apparatus (13),
Pipeline is additionally provided between dialyzate outlet and dialysis fluid container (14) on dialyzer, the regenerating unit (13) is series at
In pipeline on dialyzer between dialyzate outlet and dialysis fluid container (14)；
Dialyzate entrance and dialyzate hold on pipeline, dialyzer on dialyzer between dialyzate outlet and dialysis fluid container (14)
Pipeline, dialysis liquid pump, dialyzer, regenerating unit (13), dialysis fluid container (14) between device (14) are collectively constituted for dialysing
The dynamic loop of liquid recycle stream.
3. a kind of wearable artificial kidney according to claim 1, it is characterised in that also include being connected on dialyzer dialysing
Ultrafiltrate pump (12) in liquid outlet.
A kind of 4. wearable artificial kidney as claimed in any of claims 1 to 3, it is characterised in that the dialyzer
Including dialyzer housing (1), be additionally provided with dialyzer housing (1) blood entry port interface (5), dialyzate discharge coupling (6), thoroughly
Liquid ingress interface (7) and blood discharge coupling (8) are analysed, dialysis tubing (3) is additionally provided with dialyzer housing (1), in addition to set
In the resistive portion (2) in dialyzer housing (1), the resistive portion (2) is located at the outside of dialysis tubing (3), and resistive portion (2) is located at
Between dialyzate discharge coupling (6) and dialyzate ingress interface (7), the resistive portion (2) flows through dialysis for increasing dialyzate
The resistance of device；
The blood pump (11) is connected by blood entry port interface (5) with dialyzer；
The blood discharge coupling (8) is used to connect the pipeline that blood is led back to human body；
The dialyzate ingress interface (7) is used to connect dialysis liquid pump (15)；
The dialyzate that the dialyzate discharge coupling (6) is used to use by dialyzer discharges dialyzer.
5. a kind of wearable artificial kidney according to claim 4, it is characterised in that the resistive portion (2) is dialyzer shell
Size reduction section on body (1).
6. a kind of wearable artificial kidney according to claim 5, it is characterised in that the size reduction section and dialysis tubing
(3) also have between and be used for the gap that dialyzate passes through.
A kind of 7. wearable artificial kidney according to claim 4, it is characterised in that the dialyzer housing (1) is in the form of a column,
Blood entry port interface (5) is arranged on the different ends of dialyzer housing (1) from blood discharge coupling (8)；
The both ends of the dialyzer housing (1) are provided with tube sheet (4), each tube sheet (4) with end dialyzer housing (1) where it
End surround blood room (9)；
The dialysis tubing (3) is more, and each dialysis tubing (3) is installed between two tube sheets (4), and each dialysis tubing (3) is two
Communicating pipe between blood room (9)；
Dialyzate discharge coupling (6) and dialyzate ingress interface (7) are arranged in the region between two tube sheets (4).
8. a kind of wearable artificial kidney according to claim 7, it is characterised in that the dialyzate ingress interface (7) sets
One end that blood discharge coupling (8) is set on dialyzer housing (1) is put, the dialyzate discharge coupling (6) is arranged on dialysis
One end of blood entry port interface (5) is set on device housing (1).
9. a kind of wearable artificial kidney according to claim 4, it is characterised in that the dialyzer housing (1) is in cylinder
Shape；
The resistive portion (2) is the undergauge section on dialyzer housing (1)；
Flex point is additionally provided with the original position and final position of the undergauge section, part or all of dialysis tubing (3), each dialysis
Flex point on pipe (3) causes the dialysis tubing (3) at undergauge fragment position closer to the middle part of dialyzer housing (1).
A kind of 10. wearable artificial kidney according to claim 9, it is characterised in that dialysis tubing (3) and dialysis tubing (3) it
Between, between dialysis tubing (3) and dialyzer housing (1) be respectively provided with gap.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710908855.8A CN107469170A (en) | 2017-09-29 | 2017-09-29 | A kind of wearable artificial kidney |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710908855.8A CN107469170A (en) | 2017-09-29 | 2017-09-29 | A kind of wearable artificial kidney |
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Family
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| CN201710908855.8A Pending CN107469170A (en) | 2017-09-29 | 2017-09-29 | A kind of wearable artificial kidney |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111202880A (en) * | 2020-02-03 | 2020-05-29 | 深圳汉诺医疗科技有限公司 | Purifying column, device and method for purifying blood |
| CN112672678A (en) * | 2018-06-27 | 2021-04-16 | 日内瓦基金会 | Wearable modular in vitro life support device for mobile treatment of single and multiple organ failure |
| WO2021080538A1 (en) * | 2019-10-23 | 2021-04-29 | Canakkale Onsekiz Mart Universitesi Rektorlugu | Hemodialysis system in the form of a wearable vest |
| WO2022133582A1 (en) * | 2020-12-21 | 2022-06-30 | Volutrol Inc. | Wearable hemofiltration artificial kidney |
| WO2022133574A1 (en) * | 2020-12-21 | 2022-06-30 | Volutrol Inc. | Wearable hemofiltration artificial kidney |
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| JPH11319079A (en) * | 1998-05-12 | 1999-11-24 | Nikkiso Co Ltd | Hollow fiber type hemodialyzer |
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| CN112672678A (en) * | 2018-06-27 | 2021-04-16 | 日内瓦基金会 | Wearable modular in vitro life support device for mobile treatment of single and multiple organ failure |
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| WO2022133582A1 (en) * | 2020-12-21 | 2022-06-30 | Volutrol Inc. | Wearable hemofiltration artificial kidney |
| WO2022133574A1 (en) * | 2020-12-21 | 2022-06-30 | Volutrol Inc. | Wearable hemofiltration artificial kidney |
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