CN107468766A - A kind of ointment for treating frostbite and preparation method thereof - Google Patents
A kind of ointment for treating frostbite and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of ointment for treating pernio, including Chinese medical concrete and matrix, the Chinese medical concrete is made up of the raw material including following parts by weight：70 100 parts of its sole, 40 60 parts of Chinese holly, 40 60 parts of Ammopiptanthus mongolicus, 55 65 parts of selfheal, thorn 55 60 parts of knotweed, windproof 35 45 parts, the matrix is made up of the raw material including following parts by weight：8 12 parts of vaseline, 7 10 parts of stearic acid, 46 parts of atoleine, 8 12 parts of glycerine, 0.2 0.4 parts of triethanolamine, 50 60 parts of deionized water；And provide its preparation method.The ointment has the function that clearing heat and detoxicating, subsiding swelling and resolving stagnation, relaxing tendons and activating collaterals, antalgesic-antipruritic, for once, two degree of frostbite have good therapeutic effect.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, in particular it relates to a kind of ointment for treating frostbite and preparation method thereof.
Background technology
Frostbite is due to body local caused by cold wet effect or whole body damage.Low temperature is in when the body long period
When being stimulated with humidity, the angiogenesis spasm of body surface will be made, therefore blood flow is reduced, cause tissue ischemia anoxic, cell
Sustain damage, especially the poor position of far-end of limb blood circulation, such as toe.The transient damage of skin can be caused when light,
Treatment in time；Permanent disfunction can be caused during weight, professional treatment need to be carried out.When serious can threat to life, need to promptly rescue.
Trick frostbite is common phenomenon, particularly in the winter time.Once frostbite damaged part was in epidermis, two degree of frostbite wounds
And skin corium, three degree of frostbite injure skin holostrome, four degree of frostbite injure skin, hypodermis, muscle even bone.Wherein one
Degree, two degree of frostbite belong to slight frostbite.The medicine for the treatment of frostbite has Chinese medicine ointment and Western medicine ointment at present, but in therapeutic effect
Aspect is difficult to reach promising result.
The content of the invention
First purpose of the present invention is to overcome drawbacks described above, there is provided a kind of ointment for treating frostbite.
Second object of the present invention is to provide the preparation method of above-mentioned ointment.
The purpose of the present invention implements by the following technical programs：
A kind of ointment for treating pernio, including Chinese medical concrete and matrix, the Chinese medical concrete is by including following parts by weight
Raw material is made：
Its sole 70-100 parts, Chinese holly 40-60 parts, Ammopiptanthus mongolicus 40-60 parts, selfheal 55-65 parts, thorn knotweed 55-65 parts,
Windproof 35-45 parts,
The matrix is made up of the raw material including following parts by weight：
Vaseline 8-12 parts, stearic acid 7-10 parts, atoleine 4-6 parts, glycerine 8-12 parts, triethanolamine 0.2-0.4 parts,
Deionized water 50-60 parts.
Preferably, the Chinese medical concrete is made up of the raw material of following parts by weight：
80 parts of its sole, 50 parts of Chinese holly, 50 parts of Ammopiptanthus mongolicus, 60 parts of selfheal, thorn 60 parts of knotweed, windproof 40 parts,
The matrix is made up of the raw material of following parts by weight：
10 parts of vaseline, 8 parts of stearic acid, 5 parts of atoleine, 10 parts of glycerine, 0.3 part of triethanolamine, 55 parts of deionized water.
The preparation method of the ointment of above-mentioned treatment pernio, ethanol is added in day sole, Chinese holly, Ammopiptanthus mongolicus, is first surpassed
Sound extracts, then carries out secondary back extraction, and extract solution merges, and filtering, concentration and recovery ethanol, obtains the first medicinal extract；Selfheal, thorn
Knotweed, windproof middle addition ethanol, first carry out ultrasonic extraction, then carry out secondary back extraction, and extract solution merges, filtering, concentration and recovery
Ethanol, obtain the second medicinal extract；Vaseline and stearic acid heating fusing, add deionized water, atoleine, glycerine and triethanolamine,
It is well mixed, the first medicinal extract and the second medicinal extract are added, is well mixed, is cooled down and produce.
Further, methods described specifically includes following steps：
(1) a day sole, Chinese holly, Ammopiptanthus mongolicus, selfheal, thorn knotweed, windproof are weighed, crushes respectively, obtains day sole powder, a four seasons
Blue or green powder, Ammopiptanthus mongolicus powder, selfheal powder, thorn knotweed powder, windproof powder；
(2) day sole powder, Chinese holly powder, the Ammopiptanthus mongolicus powder obtained step (1) mixes, and adds ethanol, first carries out ultrasound
Ripple is extracted, and liquid then is poured into progress first time refluxing extraction in refluxing extraction equipment, filtrate is collected by filtration, and is added ethanol and is entered
Second of refluxing extraction of row, is collected by filtration filtrate, and the filtrate obtained twice merges, and filtering, concentration and recovery ethanol, obtains the first leaching
Cream；
(3) selfheal powder, thorn knotweed powder, the windproof powder obtained step (1) mixes, and adds ethanol, first carries out ultrasonic wave and carry
Take, liquid is then poured into refluxing extraction equipment progress first time refluxing extraction, filtrate is collected by filtration, add ethanol and carry out the
Secondary back extracts, and filtrate is collected by filtration, and the filtrate obtained twice merges, and filtering, concentration and recovery ethanol, obtains the second medicinal extract；
(4) vaseline and stearic acid are put into container, heating fusing, are slowly added to deionized water, atoleine, glycerine
And triethanolamine, and it is stirred continuously, the first medicinal extract that step (2) obtains and step (3) obtains second is added after well mixed
Medicinal extract, stir, cool down and produce.
Further, the volume fraction of the ethanol is 80%.
Further, in the step (2), the weight ratio of ethanol and medicinal material is 5-6 during ultrasonic wave extraction:1, ultrasonic wave
Extraction time is 20-25min.
Further, in the step (2), first time reflux extracting time is 2.5-3h,
During second of refluxing extraction, the addition of ethanol is 3-4 times of medicinal material weight, extraction time 1.5-2h.
Further, in the step (3), the weight ratio of ethanol and medicinal material is 5-6 during ultrasonic wave extraction:1, ultrasonic wave
Extraction time is 15-20min.
Further, in the step (3), first time reflux extracting time is 2-2.5h,
During second of refluxing extraction, the addition of ethanol is 3-4 times of medicinal material weight, extraction time 1.5-2h.
Further, in the step (4), the container is aluminium vessel.
The effect of each raw material of ointment of the treatment frostbite of the present invention is as follows：
Its sole：Bitter, cool in nature, returns spleen, large intestine channel, there is the effect of clearing heat and detoxicating, swelling and pain relieving；
Chinese holly：Bitter, puckery, cool in nature, return lung, large intestine, bladder warp, there is the effect of clearing heat and detoxicating, subsiding swelling and resolving stagnation；
Ammopiptanthus mongolicus：Bitter, micro-pungent, warm-natured, thoughts of returning home warp, there is the effect of dispelling wind and eliminating dampness, relaxing tendons and activating collaterals；
Selfheal：Acrid flavour, hardship, cold in nature, Return liver, gallbladder channel, there is the effect of clearing liver-fire, improving eyesight, mass dissipating and swelling eliminating；
Pierce knotweed：Sour, micro-pungent, it is mild-natured, there is the effect of removing toxicity for detumescence, removing dampness through diuresis and relieving itching；
It is windproof：Acrid flavour, sweet, slightly warm in nature, return bladder, lung, spleen, Liver Channel, have expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, only convulsion work(
Effect.
The invention has the advantages that：
The ointment for the treatment of frostbite provided by the invention, has clearing heat and detoxicating, subsiding swelling and resolving stagnation, relaxing tendons and activating collaterals, antalgesic-antipruritic
Effect, for once, two degree of frostbite have good therapeutic effect.
Embodiment
The preferred embodiments of the present invention are illustrated below, it will be appreciated that preferred embodiment described herein is only used
In the description and interpretation present invention, it is not intended to limit the present invention.
Raw material in the embodiment of the present invention is that market can obtain product.
Embodiment 1
A kind of ointment for frostbite, preparation method are as follows：
(1) by weight, 80 parts of day sole, 50 parts of Chinese holly, 50 parts of Ammopiptanthus mongolicus, 60 parts of selfheal, thorn knotweed 60 are weighed
Part, it is windproof 40 parts, crush respectively, obtain a day sole powder, Chinese holly powder, Ammopiptanthus mongolicus powder, selfheal powder, thorn knotweed powder, windproof powder.
(2) above-mentioned day sole powder, Chinese holly powder, Ammopiptanthus mongolicus powder are mixed, add the 80vt% ethanol of 6 times of medicinal material weight,
Ultrasonic wave extraction 25min, then liquid is poured into refluxing extraction equipment, refluxing extraction 2.5h, filtrate is collected by filtration, adds
The 80vt% ethanol of 4 times of medicinal material weight, secondary back extraction is carried out, extraction time 2h, filtrate is collected by filtration, the filter obtained twice
Liquid merges, and filtering, concentration and recovery ethanol, obtains the first medicinal extract.
(3) above-mentioned selfheal powder, thorn knotweed powder, windproof powder are mixed, adds the 80vt% ethanol of 6 times of medicinal material weight, ultrasound
Ripple extracts 20min, then pours into refluxing extraction equipment liquid, refluxing extraction 2h, filtrate is collected by filtration, adds medicinal material weight
The 80vt% ethanol of 4 times of amount, secondary back extraction is carried out, extraction time 2h, filtrate is collected by filtration, the filtrate obtained twice is closed
And filter, concentration and recovery ethanol, obtain the second medicinal extract.
(4) 10 parts of vaseline and 8 parts of stearic acid are put into aluminium vessel, heating fusing, are slowly added to 55 parts of deionizations
Water, 5 parts of atoleines, 10 parts of glycerine and 0.3 part of triethanolamine, and be stirred continuously, the first medicinal extract and the are added after well mixed
Two medicinal extract, stir, and cool down and produce.
Hand freezes the wounded, and female, 16 years old, every winter hand was red and swollen, and hand has more violent gargalesthesia under warm conditions, and category once froze
Wound.Treated with the ointment of the present embodiment, place of itching is applied to after the daily morning and evening is clean, skin recovers normal after 8 days, and gargalesthesia disappears
Lose, without recurrence after January.
Embodiment 2
A kind of ointment for frostbite, preparation method are as follows：
(1) by weight, 70 parts of day sole, 60 parts of Chinese holly, 60 parts of Ammopiptanthus mongolicus, 65 parts of selfheal, thorn knotweed 65 are weighed
Part, it is windproof 35 parts, crush respectively, obtain a day sole powder, Chinese holly powder, Ammopiptanthus mongolicus powder, selfheal powder, thorn knotweed powder, windproof powder.
(2) above-mentioned day sole powder, Chinese holly powder, Ammopiptanthus mongolicus powder are mixed, add the 80vt% ethanol of 5 times of medicinal material weight,
Ultrasonic wave extraction 25min, then liquid is poured into refluxing extraction equipment, refluxing extraction 3h, filtrate is collected by filtration, adds medicine
The 80vt% ethanol of 4 times of material weight, secondary back extraction is carried out, extraction time 1.5h, filtrate is collected by filtration, the filter obtained twice
Liquid merges, and filtering, concentration and recovery ethanol, obtains the first medicinal extract.
(3) above-mentioned selfheal powder, thorn knotweed powder, windproof powder are mixed, adds the 80vt% ethanol of 6 times of medicinal material weight, ultrasound
Ripple extracts 15min, then pours into refluxing extraction equipment liquid, refluxing extraction 2.5h, filtrate is collected by filtration, adds medicinal material
The 80vt% ethanol of 3 times of weight, secondary back extraction is carried out, extraction time 1.5h, filtrate is collected by filtration, the filtrate obtained twice
Merge, filtering, concentration and recovery ethanol, obtain the second medicinal extract.
(4) 8 parts of vaseline and 10 parts of stearic acid are put into aluminium vessel, heating fusing, are slowly added to 60 parts of deionizations
Water, 4 parts of atoleines, 8 parts of glycerine and 0.4 part of triethanolamine, and be stirred continuously, add the first medicinal extract and second after well mixed
Medicinal extract, stir, cool down and produce.
Pig's feets in aspic the wounded, female, 22 years old, foot's sufferings under warm conditions, scratch brokenly, two degree of frostbite of number.With the medicine of the present embodiment
Cream is treated, and is applied to place of itching after daily evening foot bath, is wrapped up with gauze, and sufferings disappear after 14 days, skin healing, after January
Without recurrence.
Embodiment 3
A kind of ointment for frostbite, preparation method are as follows：
(1) by weight, 100 parts of day sole, 40 parts of Chinese holly, 40 parts of Ammopiptanthus mongolicus, 55 parts of selfheal, thorn knotweed 55 are weighed
Part, it is windproof 45 parts, crush respectively, obtain a day sole powder, Chinese holly powder, Ammopiptanthus mongolicus powder, selfheal powder, thorn knotweed powder, windproof powder.
(2) above-mentioned day sole powder, Chinese holly powder, Ammopiptanthus mongolicus powder are mixed, add the 80vt% ethanol of 6 times of medicinal material weight,
Ultrasonic wave extraction 20min, then liquid is poured into refluxing extraction equipment, refluxing extraction 3h, filtrate is collected by filtration, adds medicine
The 80vt% ethanol of 3 times of material weight, secondary back extraction is carried out, extraction time 1.5h, filtrate is collected by filtration, the filter obtained twice
Liquid merges, and filtering, concentration and recovery ethanol, obtains the first medicinal extract.
(3) above-mentioned selfheal powder, thorn knotweed powder, windproof powder are mixed, adds the 80vt% ethanol of 5 times of medicinal material weight, ultrasound
Ripple extracts 20min, then pours into refluxing extraction equipment liquid, refluxing extraction 2h, filtrate is collected by filtration, adds medicinal material weight
The 80vt% ethanol of 4 times of amount, secondary back extraction is carried out, extraction time 2h, filtrate is collected by filtration, the filtrate obtained twice is closed
And filter, concentration and recovery ethanol, obtain the second medicinal extract.
(4) 12 parts of vaseline and 7 parts of stearic acid are put into aluminium vessel, heating fusing, are slowly added to 50 parts of deionizations
Water, 6 parts of atoleines, 12 parts of glycerine and 0.2 part of triethanolamine, and be stirred continuously, the first medicinal extract and the are added after well mixed
Two medicinal extract, stir, and cool down and produce.
Ear freezes the wounded, man, 10 years old, because winter often plays in outdoor, ear frostbite, and suppurate, number once froze
Wound.Treated with the ointment of the present embodiment, place of itching is applied to after the daily morning and evening is clean, skin recovers normal after 10 days, painless
Itch phenomenon, without recurrence after January.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention, although with reference to foregoing reality
Apply example the present invention is described in detail, for those skilled in the art, it still can be to foregoing each implementation
Technical scheme described in example is modified, or carries out equivalent substitution to which part technical characteristic.All essences in the present invention
God any modification, equivalent substitution and improvements made etc., should be included in the scope of the protection with principle.
Claims (10)
1. a kind of ointment for treating pernio, including Chinese medical concrete and matrix, it is characterised in that the Chinese medical concrete is by including as follows
The raw material of parts by weight is made：
It is its sole 70-100 parts, Chinese holly 40-60 parts, Ammopiptanthus mongolicus 40-60 parts, selfheal 55-65 parts, thorn knotweed 55-65 parts, windproof
35-45 parts,
The matrix is made up of the raw material including following parts by weight：
Vaseline 8-12 parts, stearic acid 7-10 parts, atoleine 4-6 parts, glycerine 8-12 parts, triethanolamine 0.2-0.4 parts, go from
Sub- water 50-60 parts.
2. the ointment for the treatment of pernio according to claim 1, it is characterised in that the Chinese medical concrete is by following parts by weight
Raw material is made：
80 parts of its sole, 50 parts of Chinese holly, 50 parts of Ammopiptanthus mongolicus, 60 parts of selfheal, thorn 60 parts of knotweed, windproof 40 parts,
The matrix is made up of the raw material of following parts by weight：
10 parts of vaseline, 8 parts of stearic acid, 5 parts of atoleine, 10 parts of glycerine, 0.3 part of triethanolamine, 55 parts of deionized water.
3. the preparation method of the ointment of the treatment pernio described in claim 1 or 2, it is characterised in that day sole, Chinese holly, sand
Ethanol is added in Chinese ilex, first carries out ultrasonic extraction, then carries out secondary back extraction, extract solution merges, filtering, concentration and recovery second
Alcohol, obtain the first medicinal extract；Selfheal, thorn knotweed, windproof middle addition ethanol, first carry out ultrasonic extraction, then carry out secondary back extraction, carry
Take liquid to merge, filter, concentration and recovery ethanol, obtain the second medicinal extract；Vaseline and stearic acid heating fusing, add deionized water, liquid
Body paraffin, glycerine and triethanolamine, it is well mixed, adds the first medicinal extract and the second medicinal extract, is well mixed, cools down and produce.
4. the preparation method of the ointment for the treatment of pernio according to claim 3, it is characterised in that methods described specifically includes
Following steps：
(1) a day sole, Chinese holly, Ammopiptanthus mongolicus, selfheal, thorn knotweed, windproof are weighed, crushes respectively, obtains day sole powder, a Chinese holly
Powder, Ammopiptanthus mongolicus powder, selfheal powder, thorn knotweed powder, windproof powder；
(2) day sole powder, Chinese holly powder, the Ammopiptanthus mongolicus powder obtained step (1) mixes, and adds ethanol, first carries out ultrasonic wave and carries
Take, liquid is then poured into refluxing extraction equipment progress first time refluxing extraction, filtrate is collected by filtration, add ethanol and carry out the
Secondary back extracts, and filtrate is collected by filtration, and the filtrate obtained twice merges, and filtering, concentration and recovery ethanol, obtains the first medicinal extract；
(3) selfheal powder, thorn knotweed powder, the windproof powder obtained step (1) mixes, and adds ethanol, first carries out ultrasonic wave extraction, so
Liquid is poured into progress first time refluxing extraction in refluxing extraction equipment afterwards, filtrate is collected by filtration, ethanol is added and carries out second
Refluxing extraction, filtrate is collected by filtration, the filtrate obtained twice merges, and filtering, concentration and recovery ethanol, obtains the second medicinal extract；
(4) vaseline and stearic acid are put into container, heating fusing, are slowly added to deionized water, atoleine, glycerine and three
Monoethanolamine, and be stirred continuously, the second medicinal extract that the first medicinal extract and step (3) that addition step (2) obtains after being well mixed obtain,
Stir, cool down and produce.
5. the preparation method of the ointment for the treatment of frostbite according to claim 4, it is characterised in that the volume integral of the ethanol
Number is 80%.
6. the preparation method of the ointment for the treatment of frostbite according to claim 4, it is characterised in that in the step (2), surpass
The weight ratio of ethanol and medicinal material is 5-6 when sound wave extracts:1, the ultrasonic wave extraction time is 20-25min.
7. the preparation method of the ointment for the treatment of frostbite according to claim 4, it is characterised in that in the step (2), the
Reflux extracting time is 2.5-3h,
During second of refluxing extraction, the addition of ethanol is 3-4 times of medicinal material weight, extraction time 1.5-2h.
8. the preparation method of the ointment for the treatment of frostbite according to claim 4, it is characterised in that in the step (3), surpass
The weight ratio of ethanol and medicinal material is 5-6 when sound wave extracts:1, the ultrasonic wave extraction time is 15-20min.
9. the preparation method of the ointment for the treatment of frostbite according to claim 4, it is characterised in that in the step (3), the
Reflux extracting time is 2-2.5h,
During second of refluxing extraction, the addition of ethanol is 3-4 times of medicinal material weight, extraction time 1.5-2h.
10. the preparation method of the ointment for the treatment of frostbite according to claim 4, it is characterised in that in the step (4),
The container is aluminium vessel.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111655274A (en) * | 2018-01-29 | 2020-09-11 | 全北大学校产学协力团 | Composition for preventing and treating xerophthalmia comprising extract of aucuba japonica |
| CN111655274B (en) * | 2018-01-29 | 2022-05-10 | 全北大学校产学协力团 | Composition for preventing and treating xerophthalmia comprising extract of aucuba japonica |
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Application publication date: 20171215 |