CN107468711A - A kind of preparation method of the Hydrolysis kinetics extractum hepatis cream from pork liver - Google Patents
A kind of preparation method of the Hydrolysis kinetics extractum hepatis cream from pork liver Download PDFInfo
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Abstract
The present invention relates to the field of Chinese medicines, the preparation method of particularly a kind of Hydrolysis kinetics extractum hepatis cream from pork liver, including the processes such as water extraction, concentration, alcohol precipitation, water is heavy, pork liver is rubbed into pureed, its active ingredient is obtained and is easier to extract；Control 0.1% that acid adding amount is pork liver amount so that mixture ph avoids the digestion phenomenon that acid adding is excessively brought between 4~5（Impurity can be increased）, ph is between 4~5 most beneficial for active ingredient dissolution；It is 90~95 DEG C to control Extracting temperature, and is aided with intermittent stirring mode, and concentration remains active ingredient to greatest extent using the mode that is concentrated under reduced pressure；Net system, purification can be carried out to active ingredient using alcohol precipitation mode, further reduces impurity；Alcohol cream adds water to enter water-filling to sink, filtered out water-insoluble materials, avoid being used for deposited phenomenon occur during liquid preparation.By extractum hepatis cream made from this method, its purity is higher, it is water-soluble it is more preferable, stability is higher, the liquid or solid formulation of various food, health products, pharmaceutical preparation can be made an addition to.
Description
Technical field
The present invention relates to the field of Chinese medicines, the preparation method of particularly a kind of Hydrolysis kinetics extractum hepatis cream from pork liver.
Background technology
Extractum hepatis cream is a kind of refined extract of animal's liver, and it is common that animal, which is primarily referred to as pig, ox, sheep, especially pig,.
Pork liver is pig category animal pig Sus scrofa domestica Brisson liver.After slaughtering, cut open the belly and take liver, using fresh herb or cold
Hide.Theory of traditional Chinese medical science：It has the effect of nourishing liver and improving eyesight, blood-nourishing invigorating the spleen；Cure mainly the empty blurred vision of liver, yctalopia, blood deficiency chlorosis, children's infantile malnutrition due to digestive disturbances or intestinalparasites
Product, beriberi edema, oedema, protracted dysentery, prolapse of the anus, with.100 grams of pork livers contain：21.3 grams of protein, 4.5 grams of fat, carbon hydrate
1.4 grams of thing, 11 milligrams of calcium, 270 milligrams of phosphorus, 25.0 milligrams of iron, 5.78 milligrams of zinc, 0.40 milligram of thiamine, Riboflavin Tetrabutyrate .11 millis
Gram, 16.2 milligrams of niacin, 18 milligrams of ascorbic acid.Liver is storage nutriment and the vitals of removing toxic substances in animal body, is contained
Abundant nutriment, there is alimentary health-care function, be optimal one of good merchantable brand of enriching blood.
Extraction for liver, Enzymatic Extraction can be used, recovery rate is higher, but composition is complex to contain a large amount of eggs
White matter catabolite；Using sour formulation, recovery rate is relatively low, but composition is sought so that water soluble vitamin, iron, zinc, calcium, phosphorus etc. are water-soluble
Form and be divided into master, without protein digestion product, composition is more simple, and after refining, composition is more simple, can be used for mixture
Production.There were significant differences for both applicabilities.It is respectively suitable for different preparation productions.
The production of mixture needs the refined liver extract i.e. extractum hepatis cream of the process of the steady quality of good water solubility, and current
There has been no relevant report.
The content of the invention
For the above situation, to overcome prior art defect, the purpose of the present invention is just to provide one kind and extracted from pork liver
The preparation method of refined extractum hepatis cream, can effectively solve existing liver extract i.e. liver extract purity difference, easily precipitate, be unstable, no
The problem of being produced suitable for fluid products such as mixture.
The technical proposal of the invention is realized in this way：A kind of preparation method of the Hydrolysis kinetics extractum hepatis cream from pork liver, bag
Include following steps：
Step 1：Pork liver is removed into non-liver tissue, cleans, rubbed with meat grinder, be in pureed or pasty state after rubbing, into pork liver
Add water, amount of water is the 50 ~ 60% of pork liver weight；
Step 2：The pork liver of step 1 is added into hydrochloric acid or 1:1 sulfuric acid, hydrochloric acid or 1:The addition of 1 sulfuric acid is pork liver weight
0.07 ~ 0.12%, 1:1 sulfuric acid refers to water and sulfuric acid volume ratio 1:1, add water to mix during acid adding, the pH value for making acid solution is 4.0 ~ 5.0；
Step 3：The pork liver of step 2 is stirred, mixing speed is 20 ~ 30 revs/min, and mixed liquor is heated under agitation
To 90~95 DEG C, after insulation 35 ~ 45 minutes, stop heating, it is intermittent under keeping warm mode to open stirring 2~5 times, every time 2~5
Minute, liquid temperature degree to be mixed, which is down to after less than 45 DEG C, carries out first time filterings, and filter residue adds water, amount of water be pork liver weight 55~
65%, stirring is opened, mixing speed is 20 ~ 30 revs/min, is heated to 90~95 DEG C to mixed liquor under agitation, insulation 35 ~ 45
After minute, stop heating, intermittence unlatching stirring 2~5 times under keeping warm mode, 2~5 minutes every time, liquid temperature degree drop to be mixed
Carry out filtering for second after to less than 45 DEG C, merge the filtrate of filtering and second of filtering for the first time, be concentrated under reduced pressure, after concentration
To caking solid, liver extract is produced；
Step 4：Ethanol will be added in the liver extract obtained in step 3, the alcoholic strength for making ethanol is 60~80%, stands 22
~26 hours, filtering, ethanol content is concentrated into filtrate decompression less than 0.5%, alcohol cream is produced after concentration；
Step 5：Take the alcohol cream of step 4, in alcohol cream plus water, alcohol cream and water mixed, at 2 ~ 10 DEG C refrigeration stand 22~
26 hours, filter, the weight of alcohol cream, produces extractum hepatis cream, the total recovery of extractum hepatis cream is before being added water in filtrate to filtering（40~
130）/1300.
Preferably, the addition of hydrochloric acid or sulfuric acid is the 0.1% of pork liver weight in the step 2.
Preferably, the percentage by weight of moisture is 30% ~ 40% in liver extract in the step 3.
Preferably, be concentrated under reduced pressure in the step 4 using mono-/bis-effect vacuum concentrator, the time that is concentrated under reduced pressure for 1 ~
4 hours, the temperature being concentrated under reduced pressure was 45~70 DEG C, and vacuum is~0.088 ± 0.002MPa.
Preferably, alcohol cream and water are mixed using Agitation Tank in the step 5, blending process mixing speed is 30 ~ 40
Rev/min.
The invention has the advantages that：The invention provides a kind of preparation side of the Hydrolysis kinetics extractum hepatis cream from pork liver
Method, by extractum hepatis cream made from this method, its purity is higher, it is water-soluble it is more preferable, stability is higher, various foods can be made an addition to
Product, health products, the liquid or solid formulation of pharmaceutical preparation, can also be used alone, and for enriching blood, be particularly suitable for use in mixture extractum hepatis
Enrich blood the production of plain oral liquid.Had the advantage that using the method for the present invention：Pork liver is rubbed into pureed so that its effectively into
Divide and be easier to extract；Control 0.1% that acid adding amount is pork liver amount so that mixture ph avoids acid adding excess band between 4 ~ 5
The digestion phenomenon come（Impurity can be increased）, ph is between 4 ~ 5 most beneficial for active ingredient dissolution；It is 90 to control Extracting temperature
~95 DEG C, and it is aided with intermittent stirring mode, concentration remains active ingredient to greatest extent using the mode that is concentrated under reduced pressure；Use alcohol precipitation
Mode can carry out net system, purification to active ingredient, further reduce impurity；Alcohol cream adds water to enter water-filling to sink, it is insoluble to have filtered out water
Property material, avoids being used for deposited phenomenon occur during liquid preparation.
Extractum hepatis cream is to be obtained by animal's liver through the process Hydrolysis kinetics such as water extraction under acid condition, concentration, alcohol precipitation, water is heavy.
The water-soluble nutritional ingredient such as water soluble vitamin, iron, zinc, calcium, phosphorus, is enriched with Hydrolysis kinetics in liver organization, content
Lifting.Therefore extractum hepatis cream further enhances the effect enriched blood.Extractum hepatis cream can directly be taken, and be used as nutriment and enrich blood and be used,
Compound preparation use, such as Ganjing Buxuesu Oral Liquid can be made with other medicines.
Extractum hepatis cream have passed through compared with the liver extracts such as liver extract further to be refined, and is not in that precipitation etc. is unstable
Phenomenon, it can be used for the production of mixture, oral liquid.
Embodiment
The embodiment of the present invention is elaborated below in conjunction with actual conditions.
Embodiment 1：A kind of preparation method of the Hydrolysis kinetics extractum hepatis cream from pork liver, comprises the following steps：
Step 1：Pork liver is removed into non-liver tissue, cleans, rubbed with meat grinder, be in pureed or pasty state after rubbing, weigh
1300g pork liver, into pork liver plus water, amount of water are the 50% of pork liver weight, and water is the solvent of extraction；
Step 2：The pork liver of step 1 is added into hydrochloric acid, adds hydrochloric acid, hydrochloric acid addition is the 0.07% of pork liver weight, during acid adding
Water is added to mix, the pH value for making acid solution is 4.0 ~ 5.0；Whole mixture ph values are 4.0 ~ 5.0 after adding acid, water, generally at this
Nutriment dissolution situation is preferably, it is necessary to keep this weak acid environment in the range of ph values, but being unable to acid adding excessively causes to disappear
Change phenomenon, introduce other impurity；
Step 3：The pork liver of step 2 is stirred, mixing speed is 20 ~ 30 revs/min, and mixed liquor is heated under agitation
To 90 DEG C, 45 minutes are incubated, stirring 2 times is opened in keeping warm mode, 5 minutes every time, stops heating and stirring, liquid to be mixed
Temperature carries out first time filtering after being down to less than 45 DEG C, filter residue adds water, and amount of water is the 65% of pork liver weight, opens stirring, stirring
Speed is 20 ~ 30 revs/min, is heated to 90 DEG C to mixed liquor under agitation, after being incubated 35 minutes, stops heating, in insulation shape
Intermittent under state to open stirring 5 times, 2 minutes every time, liquid temperature degree to be mixed, which is down to 45 DEG C and carries out second, to be filtered, and merged the
The once filtrate of filtering and second filtering, is concentrated under reduced pressure using single-effect vacuum inspissator, the control vacuum that is concentrated under reduced pressure~
0.088 ± 0.002MPa, temperature are 45 ~ 65 DEG C, and caking solid is filtered out after concentration, obtains lotion, produces liver extract, and heating can be with
Make the cooked denaturation of pork liver, promote extraction process in addition so that active ingredient accelerates dissolution, and liver extract is acid, liver extract reclaimed water
The percentage by weight divided is 30%；
Step 4：Ethanol will be added in the liver extract obtained in step 3, adding ethanol can be dissolved in active ingredient transfer
Ethanol phase, ethanol be make as solvent ethanol alcoholic strength be 60%, stand 22 hours, filtering, filtrate decompression is concentrated into
Ethanol content is less than 0.5%, is concentrated under reduced pressure using economic benefits and social benefits vacuum concentrator, and the temperature being concentrated under reduced pressure is 45 ~ 65 DEG C, and vacuum is
0.088 ± 0.002MPa, alcohol is received into the decoction reclaimed without alcohol taste, alcohol cream is produced after concentration, alcohol cream is flowable liquid；
Step 5：The alcohol cream of step 4 is taken, 40g is added water in alcohol cream, is mixed alcohol cream and water using Agitation Tank, blending process
Mixing speed is that refrigeration stands 26 hours at 30 revs/min, 2 DEG C, filtering, is added water in filtrate to 40g, produces extractum hepatis cream, mesh
Be make extractum hepatis cream standardize, i.e., often 1300g pork livers obtain 40g liver extract.
Embodiment 2：A kind of preparation method of the Hydrolysis kinetics extractum hepatis cream from pork liver, comprises the following steps：
Step 1：Pork liver is removed into non-liver tissue, cleans, rubbed with meat grinder, be in pureed or pasty state after rubbing, weigh
1300g pork liver, into pork liver plus water, amount of water are the 60% of pork liver weight, and water is the solvent of extraction；
Step 2：The pork liver of step 1 is added into hydrochloric acid, adds hydrochloric acid, hydrochloric acid addition is the 0.12% of pork liver weight, during acid adding
Water is added to mix, the pH value for making acid solution is 4.0 ~ 5.0；Whole mixture ph values are 4 ~ 5 after adding acid, water, generally in this ph value
In the range of nutriment dissolution situation preferably, it is necessary to keep this weak acid environment, but being unable to acid adding excessively causes digestion existing
As introducing other impurity；
Step 3：The pork liver of step 2 is stirred, mixing speed is 30 revs/min, and mixed liquor is heated under agitation
95 DEG C, 35 minutes are incubated, stirring 5 times is opened in keeping warm mode, 2 minutes every time, stops heating and stirring, liquid temperature to be mixed
Degree carries out first time filtering after being down to less than 45 DEG C, filter residue adds water, and amount of water is the 55% of pork liver weight, opens stirring, stirring speed
Spend for 20 ~ 30 revs/min, be heated to 95 DEG C to mixed liquor under agitation, after being incubated 45 minutes, stop heating, in keeping warm mode
Lower intermittent open is stirred 3 times, and 4 minutes every time, liquid temperature degree to be mixed was down to 45 DEG C and filter for the second time, merges first
Secondary filtering and the filtrate of second filtering, are concentrated under reduced pressure using single-effect vacuum inspissator, the control vacuum that is concentrated under reduced pressure~
0.088 ± 0.002MPa, temperature are 45 ~ 65 DEG C, and caking solid is filtered out after concentration, obtains lotion, produces liver extract, and heating can be with
Make the cooked denaturation of pork liver, promote extraction process in addition so that active ingredient accelerates dissolution, and liver extract is acid, liver extract reclaimed water
The percentage by weight divided is 40%；
Step 4：Ethanol will be added in the liver extract obtained in step 3, adding ethanol can be dissolved in active ingredient transfer
Ethanol phase, ethanol be make as solvent ethanol alcoholic strength be 60%, stand 26 hours, filtering, filtrate decompression is concentrated into
Ethanol content is less than 0.5%, is concentrated under reduced pressure using economic benefits and social benefits vacuum concentrator, and the temperature being concentrated under reduced pressure is 45 ~ 65 DEG C, and vacuum is
0.088 ± 0.002MPa, alcohol is received into the decoction reclaimed without alcohol taste, alcohol cream is produced after concentration, alcohol cream is flowable liquid；
Step 5：The alcohol cream of step 4 is taken, 130g is added water in alcohol cream, alcohol cream and water are mixed using Agitation Tank, mixed
Journey mixing speed is that refrigeration stands 24 hours at 40 revs/min, 10 DEG C, filtering, is added water in filtrate to 130g, produces extractum hepatis
Cream, it is therefore an objective to standardize extractum hepatis cream, i.e., obtain 130g liver extract per 1300g pork livers.
Embodiment 3：A kind of preparation method of the Hydrolysis kinetics extractum hepatis cream from pork liver, comprises the following steps：
Step 1：Pork liver is removed into non-liver tissue, cleans, rubbed with meat grinder, be in pureed or pasty state after rubbing, weigh
1300g pork liver, into pork liver plus water, amount of water are the 55% of pork liver weight, and water is the solvent of extraction；
Step 2：The pork liver of step 1 is added 1：1 sulfuric acid, 1:1 sulfuric acid is water volume and sulfuric acid volume is 1:1,1：1 sulfuric acid adds
Enter 0.1% that amount is pork liver weight, add water to mix during acid adding, the pH value for making acid solution is 4.0 ~ 5.0；Entirely mixed after adding acid, water
Thing ph values are 4 ~ 5, and nutriment dissolution situation is preferable, it is necessary to keep this weak acid environment generally in the range of this ph value,
But being unable to acid adding excessively causes to digest phenomenon, introduces other impurity；
Step 3：The pork liver of step 2 is stirred, mixing speed is 25 revs/min, and mixed liquor is heated under agitation
92 DEG C, 40 minutes are incubated, stirring 3 times is opened in keeping warm mode, 3 minutes every time, stops heating and stirring, liquid temperature to be mixed
Degree carries out first time filtering after being down to less than 45 DEG C, filter residue adds water, and amount of water is the 60% of pork liver weight, opens stirring, stirring speed
Spend for 25 revs/min, be heated to 93 DEG C to mixed liquor under agitation, after insulation 40 minutes, stop heating, under keeping warm mode between
Having a rest property opens stirring 3 times, and 3 minutes every time, liquid temperature degree to be mixed was down to 45 DEG C and carries out second of filtering, merges first time mistake
Filter and the filtrate of second filtering, are concentrated under reduced pressure using single-effect vacuum inspissator, the control vacuum that is concentrated under reduced pressure~0.088 ±
0.002MPa, temperature are 45 ~ 65 DEG C, and caking solid is filtered out after concentration, obtains lotion, produces liver extract, heating can make pork liver
Cooked denaturation, promotes extraction process in addition so that active ingredient accelerates dissolution, and liver extract is acid, the weight of moisture in liver extract
It is 35% to measure percentage；
Step 4：Ethanol will be added in the liver extract obtained in step 3, adding ethanol can be dissolved in active ingredient transfer
Ethanol phase, ethanol be make as solvent ethanol alcoholic strength be 60%, stand 24 hours, filtering, filtrate decompression is concentrated into
Ethanol content is less than 0.5%, is concentrated under reduced pressure using economic benefits and social benefits vacuum concentrator, and the temperature being concentrated under reduced pressure is 45 ~ 65 DEG C, and vacuum is
~0.088 ± 0.002MPa, alcohol is received into the decoction reclaimed without alcohol taste, alcohol cream is produced after concentration, alcohol cream is flowable liquid；
Step 5：The alcohol cream of step 4 is taken, 65g is added water in alcohol cream, is mixed alcohol cream and water using Agitation Tank, blending process
Mixing speed is that refrigeration stands 24 hours at 35 revs/min, 7 DEG C, filtering, is added water in filtrate to 65g, produces extractum hepatis cream, mesh
Be make extractum hepatis cream standardize, i.e., often 1300g pork livers obtain 65g liver extract.
In above example, embodiment 3 is most preferred embodiment.
Extractum hepatis cream purity made from the method for the present invention is higher, and usual containing water-soluble solids is 10%~20%, in water not
Molten thing 1~3%；And liver extract made from other methods, usual containing water-soluble solids are 8%~15%, in water, insoluble matter is then
Up to 10~30%.Extractum hepatis cream good water solubility made from the method for the present invention, can be miscible with water, and it is settled solution to add after water, even
You have a little precipitation, can keep clarifying for a long time after filtering；And liver extract water solubility made from other methods is poor, 1:1 adds
Water can produce a large amount of precipitations, it is necessary to multiple times of filtration, can not still be placed for a long time, can produce precipitation.Made from the method for the present invention
Extractum hepatis cream stability is good, and after adding Ganjing Buxuesu Oral Liquid according to volume ratio 6.5%, after placing 3 years, solution is still clarified；
And liver extract made from other methods of same ratio, after adding Ganjing Buxuesu Oral Liquid, that is, precipitation is produced, filtering
Afterwards, one is sterilized, can precipitate again, thereafter with time lengthening, still can constantly have precipitation to produce.
Claims (5)
- A kind of 1. preparation method of the Hydrolysis kinetics extractum hepatis cream from pork liver, it is characterised in that：Comprise the following steps：Step 1：Pork liver is removed into non-liver tissue, cleans, rubbed with meat grinder, be in pureed or pasty state after rubbing, into pork liver Add water, amount of water is the 50 ~ 60% of pork liver weight；Step 2：The pork liver of step 1 is added into hydrochloric acid or 1:1 sulfuric acid, hydrochloric acid or 1:The addition of 1 sulfuric acid is pork liver weight 0.07 ~ 0.12%, 1:1 sulfuric acid refers to water and sulfuric acid volume ratio 1:1, add water to mix during acid adding, the pH value for making acid solution is 4.0 ~ 5.0；Step 3：The pork liver of step 2 is stirred, mixing speed is 20 ~ 30 revs/min, and mixed liquor is heated under agitation To 90~95 DEG C, after insulation 35 ~ 45 minutes, stop heating, it is intermittent under keeping warm mode to open stirring 2~5 times, every time 2~5 Minute, liquid temperature degree to be mixed, which is down to after less than 45 DEG C, carries out first time filterings, and filter residue adds water, amount of water be pork liver weight 55~ 65%, stirring is opened, mixing speed is 20 ~ 30 revs/min, is heated to 90~95 DEG C to mixed liquor under agitation, insulation 35 ~ 45 After minute, stop heating, intermittence unlatching stirring 2~5 times under keeping warm mode, 2~5 minutes every time, liquid temperature degree drop to be mixed Carry out filtering for second after to less than 45 DEG C, merge the filtrate of filtering and second of filtering for the first time, be concentrated under reduced pressure, after concentration To caking solid, liver extract is produced；Step 4：Ethanol will be added in the liver extract obtained in step 3, the alcoholic strength for making ethanol is 60~80%, stands 22 ~26 hours, filtering, ethanol content is concentrated into filtrate decompression less than 0.5%, alcohol cream is produced after concentration；Step 5：Take the alcohol cream of step 4, in alcohol cream plus water, alcohol cream and water mixed, at 2 ~ 10 DEG C refrigeration stand 22~ 26 hours, filter, the weight of alcohol cream, produces extractum hepatis cream, the total recovery of extractum hepatis cream is before being added water in filtrate to filtering（40~ 130）/1300.
- A kind of 2. preparation method of Hydrolysis kinetics extractum hepatis cream from pork liver according to claim 1, it is characterised in that：It is described Hydrochloric acid or 1 in step 2:The addition of 1 sulfuric acid is the 0.1% of pork liver weight.
- A kind of 3. preparation method of Hydrolysis kinetics extractum hepatis cream from pork liver according to claim 1, it is characterised in that：It is described The percentage by weight of moisture is 30% ~ 40% in liver extract in step 3.
- A kind of 4. preparation method of Hydrolysis kinetics extractum hepatis cream from pork liver according to claim 1, it is characterised in that：It is described The time is concentrated under reduced pressure in step 4 as 1 ~ 4 hour, the temperature being concentrated under reduced pressure is 45~70 DEG C, vacuum is -0.088 ± 0.002MPa。
- A kind of 5. preparation method of Hydrolysis kinetics extractum hepatis cream from pork liver according to claim 1, it is characterised in that：It is described Alcohol cream and water are mixed using Agitation Tank in step 5, blending process mixing speed is 30 ~ 40 revs/min.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114230501A (en) * | 2021-12-24 | 2022-03-25 | 河南省奥林特药业有限公司 | Preparation method of pork liver extract rich in vitamin A |
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|---|---|---|---|---|
| WO2005081612A2 (en) * | 2004-02-27 | 2005-09-09 | Mario Oda Kokuta | Solid and coated pharmaceutical composition, for veterinary use and for oral administration of active principles of disagreeable taste, and coat |
| CN103719855A (en) * | 2013-12-30 | 2014-04-16 | 徐州绿之野生物食品有限公司 | Nutritious food and production method thereof |
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2017
- 2017-08-21 CN CN201710718952.0A patent/CN107468711B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005081612A2 (en) * | 2004-02-27 | 2005-09-09 | Mario Oda Kokuta | Solid and coated pharmaceutical composition, for veterinary use and for oral administration of active principles of disagreeable taste, and coat |
| CN103719855A (en) * | 2013-12-30 | 2014-04-16 | 徐州绿之野生物食品有限公司 | Nutritious food and production method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114230501A (en) * | 2021-12-24 | 2022-03-25 | 河南省奥林特药业有限公司 | Preparation method of pork liver extract rich in vitamin A |
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