CN107468235A - Neuromodulation detects integrated system and method - Google Patents
Neuromodulation detects integrated system and method Download PDFInfo
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- CN107468235A CN107468235A CN201710640532.5A CN201710640532A CN107468235A CN 107468235 A CN107468235 A CN 107468235A CN 201710640532 A CN201710640532 A CN 201710640532A CN 107468235 A CN107468235 A CN 107468235A
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Abstract
Present disclose provides a kind of neuromodulation to detect integrated system, including：Module occurs for regulation and control event, for producing neuromodulation event, completes the nerve stimulation regulation and control to detected object, wherein, the neuromodulation event includes neuromodulation signal；Data processing module, for receiving nerve signal and the neuromodulation signal, and analyzing and processing is synchronized to the nerve signal and neuromodulation signal, to obtain the sequential relationship between nerve signal and neuromodulation signal.The disclosure additionally provides a kind of neuromodulation detection integrated approach.Disclosure neuromodulation detects integrated system and method, can effectively meet the needs of neuromodulation, simplify experimental implementation, improves conventional efficient.
Description
Technical field
The disclosure belongs to biomedical industry nerve signal recording and control technique field, and in particular to a kind of neuromodulation
Detect integrated system and method.
Background technology
Neuromodulation technology is the wide variety of research meanses of current neuroscience field, and it combines nerve information detection side
The tool such as method, the research to research neural circuitry connection, Animal Behavior Science research, nervous system mechanism and nervous system pathogenesis
There is important meaning.
At present, due to needing to wait every aspect widely to microcosmic to carry out neuromodulation again from macroscopic view to being situated between to see, thus,
When carrying out Neuroscience Research, it is necessary to which a variety of soft hardware equipments are used in combination to carry out experiment.On the one hand, because each experiment is set
The software front cover that standby manufacturer carries is totally different, and operating method is different, and, it is necessary to toggle when using each software, this
Experimental implementation can be caused cumbersome, the Preparatory work of experiment time increases, and reduces conventional efficient；On the other hand, at the same time using various softwares
When being tested, the synchronism of operation and data is all difficult to ensure that.Therefore, it is possible to integrate numerous neuromodulations and detection function
Neuromodulation detection integrated software system has great meaning to Neuroscience Research.
The content of the invention
(1) technical problems to be solved
In view of above-mentioned technical problem, can be effective present disclose provides a kind of neuromodulation detection integrated system and method
Meet the needs of neuromodulation, simplify experimental implementation, improve conventional efficient.
(2) technical scheme
According to an aspect of this disclosure, there is provided a kind of neuromodulation detects integrated system, including：Regulation and control event occurs
Module, for producing neuromodulation event, the nerve stimulation regulation and control to detected object are completed, wherein, the neuromodulation thing
Part includes neuromodulation signal；Data processing module, for receiving nerve signal and the neuromodulation signal, and to the nerve
Signal and neuromodulation signal synchronize analyzing and processing, to obtain the sequential relationship between nerve signal and neuromodulation signal.
In some embodiments of the present disclosure, the neuromodulation that module is used to produce three types occurs for the regulation and control event
Event, module, which occurs, for the regulation and control event includes：Electro photoluminescence event generating unit, for producing electro photoluminescence event；Light regulates and controls event
Generating unit, for producing light regulation and control event；And chemical stimulation event generating unit, for producing chemical stimulation event.
In some embodiments of the present disclosure, the electro photoluminescence event generating unit is used to produce voltage and/or electric current thorn
Swash, and the number and waveform of stimulation are configured, the waveform prolongs including sine wave, square wave, sawtooth waveforms, triangular wave, time
Late and combinations thereof.
In some embodiments of the present disclosure, the light regulation and control event generating unit is used in electro photoluminescence event generating unit
Voltage or electric current stimulate on the basis of by indexing the light intensity of different colored light sources and the voltage x current table of comparisons, and then select different
Light source and directly configure output intensity.
In some embodiments of the present disclosure, the chemical stimulation event generating unit, including：Parameter configuration subelement,
For setting stimulation parameter, the stimulation parameter includes excitor substance, injection rate, injection target type；Subelement is controlled, is used for
Control applies the state of chemical stimulation in real time；And state subelement, implement state for real-time display chemical stimulation.
In some embodiments of the present disclosure, the neuromodulation detection integrated system also includes：Signal reading module, use
Read electroneurographic signal, the neurochemistry signal in neuromodulation signal and nerve signal in real-time synchronization, and by reading
Signal is sent to the data processing module.
In some embodiments of the present disclosure, the data processing module, including：Pretreatment unit, for the letter
The nerve signal that module sends occurs for number read module and regulation and control event and neuromodulation signal carries out Real-Time Filtering and signal point
From；And feature extraction and Synchronization Analysis unit, for the temporal signatures and waveform of extract real-time signal, and automatic identification electricity pierces
Swash and light regulation and control event, offline synchronization analyze the signal and adjustment signal correlation of detection.
In some embodiments of the present disclosure, the neuromodulation detection integrated system also includes：Data display storage mould
Block, it is connected with the data processing module, for receiving the nerve signal and neuromodulation signal of data processing module transmission
And carry out simultaneous display and storage.
In some embodiments of the present disclosure, the data show memory module, including：Data display unit, including it is same
Display interface is walked, for realizing man-machine interaction；The display interface using multiwindow independent synchronization display detection nerve signal and
Neuromodulation signal；And data storage cell, for being protected to the primary signal of detection, characteristic signal or regulation and control event
Deposit.
According to another aspect of the disclosure, a kind of neuromodulation detection integrated approach is additionally provided, including：Produce nerve
Regulation and control event, the nerve stimulation regulation and control to detected object；The nerve of nerve signal and the neuromodulation event to detection
Adjustment signal synchronizes analyzing and processing, to obtain the sequential relationship between nerve signal and neuromodulation signal.
(3) beneficial effect
It can be seen from the above technical proposal that disclosure neuromodulation detection integrated system and method at least have with following
One of beneficial effect：
(1) nerve signal of reception and the neuromodulation signal are synchronized at analysis by data processing module
Reason, obtains the sequential relationship between nerve signal and neuromodulation signal, the synchronism of data is ensure that, to Neuroscience Research
There is great meaning.
(2) the neuromodulation detection integrated system proposed in the disclosure includes regulation and control event and module occurs, and the module possesses
Chemical stimulation event, electro photoluminescence event and light regulation and control event generating function, can provide for Neuroscience Research and be seen from macroscopic view to being situated between
The every aspect such as microcosmic is arrived again nerve signal generating function is provided, can effectively meet the needs of neuromodulation；Provide the user
Unified operating method and interface can effectively simplify experimental implementation, raising conventional efficient.
(3) the neuromodulation detection integrated system proposed in the disclosure, using signal reading module to nerve signal and god
Regulated signal synchronously read, memory module is shown using data nerve signal and neuromodulation signal are synchronized display with
Storage, nerve signal synchronization process and the display of neuromodulation signal and detection are integrated with, be avoided that due to while using a variety of
When module is tested, the problem of caused operation and the synchronisms of data are all difficult to ensure that.
Brief description of the drawings
By the way that shown in accompanying drawing, above and other purpose, the feature and advantage of the disclosure will become apparent from.In whole accompanying drawings
Identical reference indicates identical device.Deliberately accompanying drawing is not drawn by actual size equal proportion scaling, it is preferred that emphasis is show
Go out the purport of the disclosure.
Fig. 1 is to detect integrated system module diagram according to embodiment of the present disclosure neuromodulation.
Fig. 2 is the waveform method to set up flow chart according to embodiment of the present disclosure electro photoluminescence event generating unit.
Fig. 3 is to regulate and control event generating unit configured board schematic diagram according to embodiment of the present disclosure light.
Fig. 4 is according to embodiment of the present disclosure chemical stimulation event generating unit configured board schematic diagram.
Fig. 5 is according to the separation of embodiment of the present disclosure electroneurographic signal and action potential extracting method flow chart.
Embodiment
For the purpose, technical scheme and advantage of the disclosure are more clearly understood, below in conjunction with specific embodiment, and reference
Accompanying drawing, the disclosure is further described.
It should be noted that in accompanying drawing or specification description, similar or identical part all uses identical figure number.It is attached
The implementation for not illustrating or describing in figure, it is form known to a person of ordinary skill in the art in art.In addition, though this
Text can provide the demonstration of the parameter comprising particular value, it is to be understood that parameter is worth accordingly without being definitely equal to, but be able to can connect
The error margin received is similar to be worth accordingly in design constraint.The direction term mentioned in embodiment, such as " on ", " under ",
"front", "rear", "left", "right" etc., only it is the direction of refer to the attached drawing.Therefore, the direction term used is for illustrating not to use
To limit the protection domain of the disclosure.
The disclosure provides a kind of neuromodulation detection integrated system, and unified operation and interface can be achieved, including：
Module occurs for regulation and control event, and neuromodulation event can be produced according to experiment demand, preferably produces three kinds of inhomogeneities
The neuromodulation event (electro photoluminescence event, light regulation and control event and chemical stimulation event) of type, and event is transferred to neuromodulation
Detector, complete the nerve stimulation regulation and control to detected object；Wherein, the neuromodulation event includes neuromodulation signal,
Regulate and control time etc.；The neuromodulation signal includes neural light adjustment signal, neuroelectricity adjustment signal and neurochemistry regulation and control letter
Number；The neuromodulation detector is used for the nerve signal for detecting detected object and applies neuromodulation thing to detected object
Part；
Data processing module, while the nerve signal and neuromodulation signal of detection are analyzed and processed, and result is passed
It is delivered to data and shows memory module.
Wherein, module occurs for the regulation and control event, including：
Electro photoluminescence event generating unit, for producing electro photoluminescence event, it can select voltage or current system, Neng Gousheng
Into the various basic waveforms such as sine wave, square wave, sawtooth waveforms, triangular wave, time delay and combinations thereof is realized, is supported simultaneously
Random waveform is read from file；
Light regulates and controls event generating unit, and for producing light regulation and control event, it can support to select different regulation and control light sources, energy
Enough realize the setting of light intensity；
Chemical stimulation event generating unit, for producing chemical stimulation event, it can support the speed for applying chemical stimulation
The control of rate, target capacity or target duration, while chemical stimulation can be monitored in real time and implement state.
Further, the neuromodulation detection integrated system also includes：
Data show the function such as memory module, finishing man-machine interaction, signal are shown, data storage；
The data show memory module, including：
Data display unit, there is provided detection adjustment signal simultaneous display interface, can be according to the demand synchronization or only of user
The neuromodulation event on the spot showing the nerve signal of detection and occurring, and can finishing man-machine interaction function；
Data storage cell, according to the selection of user, complete the primary signal to detection, characteristic signal or regulation and control event etc.
Preservation；The primary signal is undressed nerve signal, for processed offline；The characteristic signal includes nerve action
Current potential, field potential etc..
Specifically, the data show that memory module can be connected with the neuromodulation detector, shown and deposited by data
The man-machine interactive operation that storage module interfaces are carried out to neuromodulation detector.
Further, the neuromodulation detection integrated system also includes：
Signal reading module, using ping-pong buffer mechanism, it can read from neuromodulation detector real-time synchronization
Electroneurographic signal, neurochemistry signal and neuromodulation signal, and transfer data to data processing module.
The data processing module, including：
Pretreatment unit, it is real can to realize that the data for signal reading module and regulation and control event occurring module transfer are carried out
When filtering and Signal separator；
Feature extraction and Synchronization Analysis unit, it is capable of the temporal signatures and waveform of extract real-time signal, and can automatic identification
Electro photoluminescence and light regulation and control event；Possess the functions such as signal and the adjustment signal correlation of offline synchronization analysis detection；
Preferably, for chemical stimulation event：Directly by regulating and controlling event module can occur for its neurochemistry adjustment signal
Send to neuromodulation detector, the nerve for being output to measurand through neuromodulation detector to complete to detected object pierces
Swash regulation and control；At the same time, neurochemistry adjustment signal is sent to data processing module by regulating and controlling event generation module, for data
Processing module is analyzed and processed.For electro photoluminescence event and light regulation and control event：By taking electro photoluminescence event as an example, regulate and control event
Module will regulate and control Waveform Input accordingly will regulate and control waveform and is nursed one's health, turned to neuromodulation detector, neuromodulation detector
Change and after power amplification, be output to detected object, while exported instrument by the capture card built in neuromodulation detector
Adjustment signal with detection Neural Signal Collecting, and send to signal reading module, sent by signal reading module to number
According to processing module, analyzed and processed for data processing module.
In addition, the disclosure additionally provides a kind of neuromodulation detection integrated approach, including：
Neuromodulation event is produced, the nerve stimulation regulation and control to detected object；
The neuromodulation signal of nerve signal and the neuromodulation event to detection synchronizes analyzing and processing, to obtain
Take the sequential relationship between nerve signal and neuromodulation signal.
In an exemplary embodiment of the disclosure, it is proposed that a kind of neuromodulation detects integrated system.Fig. 1 is this public affairs
Open embodiment neuromodulation detection integrated system schematic diagram.As shown in figure 1, the present embodiment neuromodulation detects integrated system, bag
Include regulation and control event and module, signal reading module, data processing module and data display memory module occurs, by using multi-thread
Journey programming mode is realized.Wherein, module, which occurs, for regulation and control event can occur to see (electro photoluminescence event) from macroscopical (chemical stimulation) to being situated between
The neuromodulation event of microcosmic (light regulation and control) three aspects is arrived again, and event is transferred to neuromodulation detector, is completed to quilt
The nerve stimulation regulation and control of examination person, while configuration parameter is transferred to data processing module；Signal reading module is examined from neuromodulation
Survey instrument and read the nerve signal (electroneurographic signal, neurochemistry signal) and neuromodulation signal of detection simultaneously, and signal is passed
It is defeated by data processing module；The nerve signal to detection and neuromodulation signal are handled data processing module in two steps, and
Result is delivered to data and shows memory module；Data show memory module, according to the demand of user simultaneously or independently
The regulation and control event for showing the nerve signal of detection and occurring, and realize the preservation to data and finishing man-machine interaction function.Below
Each part is described in detail respectively.
Regulating and controlling event generation module in embodiment of the present disclosure neuromodulation detection integrated system includes：Electro photoluminescence event occurs
Unit, light regulation and control event generating unit and chemical stimulation event generating unit, each unit distribute an independent thread.
Wherein, electro photoluminescence event generating unit supports voltage and current to stimulate two kinds of stimulation modes, can generate sine wave, square wave, saw
The various basic waveforms such as tooth ripple, triangular wave, time delay and combinations thereof is realized, while support to read any ripple from file
Shape；The number of stimulation can be set, being capable of real-time display is set on interface waveform.Its waveform compilation exports flow chart 2
It is shown：User sets stimulation mode first, selects the waveform parameter such as required waveform and setting amplitude, frequency, periodicity
Afterwards, it can select to increase other waveforms to form one group of combined waveform, and after the output cycle-index of this combined waveform is set,
By combined waveform in interface real-time display.Now if waveform sets wrong, the optional all parameters of replacement of user to acquiescence shape
State, restart to set new waveform；If errorless, waveform can be downloaded to instrument output, produce real electro photoluminescence thing
Part.Especially, the waveform that electro photoluminescence event occurs understands simultaneous transmission to data processing module.
The light regulation and control event generation for regulating and controlling event generation module in embodiment of the present disclosure neuromodulation detection integrated system is single
Member is the light intensity and current vs by indexing different colored light sources on the basis of the electric current of electro photoluminescence event generating unit stimulates
Table realizes that its light regulation and control configured board is as shown in Figure 3.Different light sources can be selected and directly configure output intensity；At this
The optional gold-tinted of light source and blue light in open embodiment, and the waveform color being shown on interface can be with selected waveform color one
Cause.It should be noted that the light source species and number on light regulation and control configured board are common settings, do not form to the disclosure
Limitation.
Chemical stimulation event generating unit in embodiment of the present disclosure neuromodulation detection integrated system, including：Parameter configuration
Subelement, for setting stimulation parameter, the stimulation parameter includes excitor substance, injection rate, injection target type etc.；Control
Unit, apply the state stimulated for controlling in real time；And state subelement, implement state for real-time display chemical stimulation.
Accordingly, the configured board of chemical stimulation event generating unit is as shown in figure 4, including two syringe information, stimulation parameter ginsengs
Number configuration plate, a control plate and a state plate.Diameter and syringe of the syringe information including injection needle
Total capacity, the total capacity of syringe determine the maximal stimulation capacity that can apply；Stimulation parameter includes excitor substance, injection speed
Rate, injection target type etc., wherein injection target type can be capacity or injection duration.Control plate can control in real time to be applied
Add the state of stimulation, and implement state in the chemical stimulation of state plate real-time display.
Signal reading module in embodiment of the present disclosure neuromodulation detection integrated system, by USB interface agreement, with data
Read the electroneurographic signal from neuromodulation detector, neurochemistry signal and neuromodulation letter the mode real-time synchronization of block
Number.In order to ensure the reliability of data, independent thread is assigned with for signal reading module, and read using ping-pong buffer mechanism
Access evidence.
Data processing module in embodiment of the present disclosure neuromodulation detection integrated system, includes pretreatment unit and feature
Extraction and Synchronization Analysis unit.Wherein, pretreatment unit believes the next electroneurographic signal of signal reading module transmission, neurochemistry
Number and neuromodulation signal be distributed, then every a kind of signal is independently filtered, the processing such as Signal separator, then by feature
Extraction and the temporal signatures and waveform of Synchronization Analysis unit extract real-time signal, and automatic identification electro photoluminescence and light regulation and control event.
Meanwhile the frequency domain character of off-line analysis signal, the nerve letter of Synchronization Analysis detection are capable of in this feature extraction with Synchronization Analysis unit
Number with adjustment signal correlation.
Electroneurographic signal data processing method and feature extraction flow are as shown in Figure 5 in the embodiment of the present disclosure.Specifically, such as
In Fig. 5 shown in (a), the original electroneurographic signal that pretreatment unit is distributed is isolated not by low pass and high-pass filter first
Same frequency content；Low pass composition forms the field potential signal of low frequency by down-sampled；High pass composition passes through such as (b) institute in Fig. 5
The action potential extraction flow shown, obtains action potential signal.In Fig. 5 shown in (b), electricity is acted using unidirectional threshold method extraction
Position：Since first passage, the data block of present period (time span default setting is 1s, adjustable) all passages is traveled through one by one
Afterwards, then start to extract the action potential of next period；When carrying out action potential extraction to each passage, obtain first current
The maximum and minimum value of channel data block, threshold value and maximum and the relation of minimum value, the anticipation for then contrasting setting are current
It whether there is action potential in data block --- if it is not, being extracted into next passage；Otherwise traversal is worked as successively
Prepass data, extract the action potential for setting length (default setting 3ms, adjustable) near all threshold points.Especially
Ground, this method can effectively improve action potential extraction efficiency as a result of anticipation function.
Neurochemistry signal-data processing method mainly uses filtering and oversampling technique, while energy in the embodiment of the present disclosure
According to current detection electrochemical source of current size, realize the adjustment to neuromodulation detector Electrochemical Detection range gear, with
On the basis of ensuring signal accuracy, ensure that signal does not exceed instrument range.
In the embodiment of the present disclosure during neuromodulation signal-data processing, to the electrically or optically neuromodulation signal of reading and regulation and control
Event occurs electrically or optically to regulate and control waveform caused by module while is filtered, then by the adjustment signal of filtered reading and production
Raw adjustment signal carries out correlation analysis, with automatic identification electro photoluminescence or light regulation and control event, and obtains accurate regulation and control thing in real time
Part time of origin.When carrying out chemical stimulation, due to its macro adjustments and controls characteristic, module occurs by chemical stimulation event to regulate and control event
The time of data processing module is transferred to as regulation and control Time To Event.
Data show memory module, including data display unit in embodiment of the present disclosure neuromodulation detection integrated system,
Detection adjustment signal simultaneous display interface is provided；And two independent threads of data storage cell.It is synchronous to detect adjustment signal
Display interface independently shows the nerve signal of detection (such as electric field potential, action potential, electrochemistry using the method for multiwindow
I-T curves etc.) and occur regulation and control event；The subwindow of array arrangement is also provided with unlike signal window, to show simultaneously
Show the data of different passages, make the data of each passage very clear, it is complete to ensure that user can be carried out to all channel signals in window
Office's observation and monitoring.Moreover, each independent window can be ejected and shown on computer interface simultaneously, realize to regulation and control event and
The simultaneous observation of detection signal.Meanwhile user can pass through the interface finishing man-machine interaction function.Data storage cell, according to
The data format of setting, complete the preservation of the primary signal to detection, characteristic signal or regulation and control event etc..
The foregoing description of the disclosed embodiments, professional and technical personnel in the field are enable to realize or using the application.
A variety of modifications to these embodiments will be apparent for those skilled in the art, as defined herein
General Principle can be realized in other embodiments in the case where not departing from spirit herein or scope.Therefore, the application
The embodiments shown herein is not intended to be limited to, and is to fit to and principles disclosed herein and features of novelty phase one
The most wide scope caused.
It should be noted that in accompanying drawing or specification text, the implementation that does not illustrate or describe is affiliated technology
Form known to a person of ordinary skill in the art, is not described in detail in field.In addition, the above-mentioned definition to each element and method is simultaneously
Various concrete structures, shape or the mode mentioned in embodiment are not limited only to, those of ordinary skill in the art can be carried out more to it
Change or replace.
Particular embodiments described above, the purpose, technical scheme and beneficial effect of the disclosure are carried out further in detail
Describe in detail bright, should be understood that the specific embodiment that the foregoing is only the disclosure, be not limited to the disclosure, it is all
Within the spirit and principle of the disclosure, any modification, equivalent substitution and improvements done etc., the guarantor of the disclosure should be included in
Within the scope of shield.
Claims (10)
1. a kind of neuromodulation detects integrated system, including：
Module occurs for regulation and control event, for producing neuromodulation event, completes the nerve stimulation regulation and control to detected object, its
In, the neuromodulation event includes neuromodulation signal；
Data processing module, for receiving nerve signal and the neuromodulation signal, and to the nerve signal and neuromodulation
Signal synchronizes analyzing and processing, to obtain the sequential relationship between nerve signal and neuromodulation signal.
2. neuromodulation according to claim 1 detects integrated system, wherein, the regulation and control event occurs module and is used to produce
The neuromodulation event of raw three types, module, which occurs, for the regulation and control event includes：
Electro photoluminescence event generating unit, for producing electro photoluminescence event；
Light regulates and controls event generating unit, for producing light regulation and control event；And
Chemical stimulation event generating unit, for producing chemical stimulation event.
3. neuromodulation according to claim 2 detects integrated system, wherein,
The electro photoluminescence event generating unit is used to produce voltage and/or electric current stimulation, and the number to stimulation and waveform progress
Set, the waveform includes sine wave, square wave, sawtooth waveforms, triangular wave, time delay and combinations thereof.
4. neuromodulation according to claim 2 detects integrated system, wherein,
The light regulation and control event generating unit is used on the basis of the voltage or electric current of electro photoluminescence event generating unit stimulate pass through
The light intensity and the voltage x current table of comparisons of different colored light sources are indexed, and then selects different light sources and directly configures output intensity.
5. neuromodulation according to claim 2 detects integrated system, wherein, the chemical stimulation event generating unit,
Including：
Parameter configuration subelement, for setting stimulation parameter, the stimulation parameter includes excitor substance, injection rate, injection target
Type；
Subelement is controlled, applies the state of chemical stimulation for controlling in real time；And
State subelement, implement state for real-time display chemical stimulation.
6. neuromodulation according to claim 1 detects integrated system, in addition to：
Signal reading module, read electroneurographic signal, nerve in neuromodulation signal and nerve signal for real-time synchronization
Chemical signal, and the signal of reading is sent to the data processing module.
7. neuromodulation according to claim 6 detects integrated system, wherein, the data processing module, including：
Pretreatment unit, the nerve signal and nerve tune sent for the signal reading module and regulation and control event occurring module
Control signal and carry out Real-Time Filtering and Signal separator；And
Feature extraction and Synchronization Analysis unit, for the temporal signatures and waveform of extract real-time signal, and automatic identification electro photoluminescence
Regulate and control event, the signal and adjustment signal correlation of offline synchronization analysis detection with light.
8. neuromodulation according to claim 1 detects integrated system, in addition to：
Data show memory module, are connected with the data processing module, for receiving the nerve of data processing module transmission
Signal and neuromodulation signal simultaneously carry out simultaneous display and storage.
9. neuromodulation according to claim 8 detects integrated system, wherein, the data show memory module, including：
Data display unit, including simultaneous display interface, for realizing man-machine interaction；The display interface is independently same using multiwindow
The nerve signal and neuromodulation signal of step display detection；And
Data storage cell, for being preserved to the primary signal of detection, characteristic signal or regulation and control event.
10. a kind of neuromodulation detects integrated approach, including：
Neuromodulation event is produced, the nerve stimulation regulation and control to detected object；
The neuromodulation signal of nerve signal and the neuromodulation event to detection synchronizes analyzing and processing, to obtain god
Through the sequential relationship between signal and neuromodulation signal.
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| CN103584851A (en) * | 2013-10-24 | 2014-02-19 | 燕山大学 | Multichannel neuron signal collection controlling and transmission device |
| CN104826243A (en) * | 2015-05-15 | 2015-08-12 | 深圳先进技术研究院 | Device for ultrasonic stimulation of neural tissue |
| CN105943031B (en) * | 2016-05-17 | 2018-12-07 | 西安交通大学 | Wearable TCD,transcranial Doppler nerve stimulation and electrophysiological recording association system and method |
| CN106108858A (en) * | 2016-09-21 | 2016-11-16 | 中国科学院电子学研究所 | A kind of light regulation and control nerve information detecting system |
| CN106175701A (en) * | 2016-09-30 | 2016-12-07 | 中国科学院电子学研究所 | A kind of nerve information photoelectricity regulation and control and bimodulus detecting system |
| CN106861043A (en) * | 2017-04-17 | 2017-06-20 | 郑州大学 | The portable nerve regulator control system of animal population agreement |
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| CN114137191A (en) * | 2021-12-29 | 2022-03-04 | 上海交通大学 | Multifunctional electrode array system for cell biochemical signal detection and regulation |
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