CN107438613B - 用于预防或治疗感觉毛细胞死亡的化合物和方法 - Google Patents

用于预防或治疗感觉毛细胞死亡的化合物和方法 Download PDF

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Publication number
CN107438613B
CN107438613B CN201680020455.7A CN201680020455A CN107438613B CN 107438613 B CN107438613 B CN 107438613B CN 201680020455 A CN201680020455 A CN 201680020455A CN 107438613 B CN107438613 B CN 107438613B
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formula
alkyl
another embodiment
compounds
compound
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Chinese (zh)
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CN107438613A (zh
Inventor
J·西蒙
格雷厄姆·约翰逊
爱德文·W·鲁贝尔
大卫·W·雷布尔
马里奥·D·冈萨雷斯
彼得·C·梅尔策
苗伟石
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Oricula Therapeutics LLC
University of Washington
Fred Hutchinson Cancer Center
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Oricula Therapeutics LLC
University of Washington
Fred Hutchinson Cancer Center
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201680020455.7A 2015-02-06 2016-02-05 用于预防或治疗感觉毛细胞死亡的化合物和方法 Active CN107438613B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562113245P 2015-02-06 2015-02-06
US62/113,245 2015-02-06
PCT/US2016/016880 WO2016127123A2 (en) 2015-02-06 2016-02-05 Compounds and methods for preventing or treating sensory hair cell death

Publications (2)

Publication Number Publication Date
CN107438613A CN107438613A (zh) 2017-12-05
CN107438613B true CN107438613B (zh) 2020-08-25

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CN201680020455.7A Active CN107438613B (zh) 2015-02-06 2016-02-05 用于预防或治疗感觉毛细胞死亡的化合物和方法

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Country Link
US (2) US10399994B2 (https=)
EP (1) EP3253766B1 (https=)
JP (1) JP6697808B2 (https=)
KR (1) KR102557184B1 (https=)
CN (1) CN107438613B (https=)
AU (1) AU2016215023B2 (https=)
CA (1) CA2974395C (https=)
DK (1) DK3253766T3 (https=)
ES (1) ES2760373T3 (https=)
WO (1) WO2016127123A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016127123A2 (en) 2015-02-06 2016-08-11 University Of Washington Compounds and methods for preventing or treating sensory hair cell death
EP3366683A1 (en) * 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Cyclic amides, acteamides and ureas useful as potassium channel openers
EP3675865B1 (en) 2017-09-01 2025-04-02 University of Washington Crystalline forms of compounds for preventing or treating sensory hair cell death
WO2020033322A1 (en) * 2018-08-06 2020-02-13 Fred Hutchinson Cancer Research Center Hearing loss-protective compounds and methods thereof
US11857551B1 (en) 2020-07-10 2024-01-02 Ting Therapeutics Llc Methods for the prevention and treatment of hearing loss
KR102848315B1 (ko) * 2022-10-27 2025-08-20 고려대학교 산학협력단 암모늄 락테이트를 유효성분으로 포함하는 난청 예방 또는 치료용 약학 조성물

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ES462993A1 (es) 1977-10-07 1978-06-01 Made Labor Sa Un procedimiento para la obtencion simultanea de 6,7,10-tri-metil-5,9-imino-4,5,8,9-tetrahidrocicloocta(b)furano y de alfa-2,4,5-trimetilfuro(2,3-f)morfano.
US4174396A (en) 1978-04-03 1979-11-13 Laboratories Made, S.A. 7,10-Dimethyl-5,9-imino-4,5,8,9-tetrahydro-cyclooct[b]thiophenes and a process for obtaining it
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Also Published As

Publication number Publication date
US20180022756A1 (en) 2018-01-25
JP6697808B2 (ja) 2020-05-27
US9493482B2 (en) 2016-11-15
CA2974395C (en) 2023-08-22
US10399994B2 (en) 2019-09-03
JP2018504411A (ja) 2018-02-15
HK1246791A1 (en) 2018-09-14
EP3253766A4 (en) 2018-07-25
EP3253766A2 (en) 2017-12-13
DK3253766T3 (da) 2019-12-09
KR20180003530A (ko) 2018-01-09
EP3253766B1 (en) 2019-09-04
WO2016127123A3 (en) 2016-10-27
AU2016215023B2 (en) 2019-12-19
WO2016127123A2 (en) 2016-08-11
KR102557184B1 (ko) 2023-07-18
CA2974395A1 (en) 2016-08-11
CN107438613A (zh) 2017-12-05
AU2016215023A1 (en) 2017-09-07
US20160229869A1 (en) 2016-08-11
ES2760373T3 (es) 2020-05-13

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