CN107428765B - 用作irak抑制剂的哒嗪酮类大环化合物及其用途 - Google Patents

用作irak抑制剂的哒嗪酮类大环化合物及其用途 Download PDF

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CN107428765B
CN107428765B CN201680018681.1A CN201680018681A CN107428765B CN 107428765 B CN107428765 B CN 107428765B CN 201680018681 A CN201680018681 A CN 201680018681A CN 107428765 B CN107428765 B CN 107428765B
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compound
disease
compounds
irak
cancer
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CN107428765A (zh
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X·陈
R·兰
C·乔兰德-勒布伦
H·余
A·古托普鲁斯
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Merck Patent GmbH
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18Bridged systems
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
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    • A61K31/50Pyridazines; Hydrogenated pyridazines
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    • C07D471/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
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CN201680018681.1A 2015-02-06 2016-02-05 用作irak抑制剂的哒嗪酮类大环化合物及其用途 Active CN107428765B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562112793P 2015-02-06 2015-02-06
US62/112,793 2015-02-06
PCT/US2016/016708 WO2016127024A1 (en) 2015-02-06 2016-02-05 Pyridazinone macrocycles as irak inhibitors and uses thereof

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CN107428765A CN107428765A (zh) 2017-12-01
CN107428765B true CN107428765B (zh) 2020-12-29

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US (2) US9624246B2 (pt)
EP (1) EP3253763B1 (pt)
JP (1) JP6920202B2 (pt)
KR (1) KR102551597B1 (pt)
CN (1) CN107428765B (pt)
AU (1) AU2016215184B2 (pt)
BR (1) BR112017014970B1 (pt)
CA (1) CA2970550C (pt)
ES (1) ES2841452T3 (pt)
HK (1) HK1246287A1 (pt)
IL (1) IL253519B (pt)
MX (1) MX2017009624A (pt)
RU (1) RU2708066C2 (pt)
SG (1) SG11201704651UA (pt)
WO (1) WO2016127024A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9624246B2 (en) * 2015-02-06 2017-04-18 Merck Patent Gmbh Pyridazinone macrocycles as IRAK inhibitors and uses thereof
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
WO2019120267A1 (zh) * 2017-12-22 2019-06-27 成都先导药物开发股份有限公司 一种咪唑并[1,2-b]哒嗪大环类激酶抑制剂
BR112020018383A2 (pt) * 2018-04-05 2020-12-29 Merck Patent Gmbh Compostos heteroarílicos como inibidores da irak tipo ii e usos dos mesmos
TWI721483B (zh) 2018-07-13 2021-03-11 美商基利科學股份有限公司 吡咯并[1,2-b]嗒𠯤衍生物
CN112533924B (zh) 2018-08-13 2023-11-28 吉利德科学公司 作为IRAK4抑制剂的吡咯并[1,2-b]哒嗪衍生物
TWI727392B (zh) 2018-08-13 2021-05-11 美商基利科學股份有限公司 噻二唑irak4抑制劑
AU2019321424B2 (en) 2018-08-13 2022-07-14 Gilead Sciences, Inc. Pyrrolo(1,2-b)pyridazine derivatives as IRAK4 inhibitors
US11998534B2 (en) * 2020-02-12 2024-06-04 Eubulus Biotherapeutics Inc. GPX4 inhibitor in combination with anticancer agent for treating proliferative disease
CN111603471B (zh) * 2020-06-24 2021-07-09 山东省科学院生物研究所 一种邻二氮杂环化合物在制备抑制tlr4受体的药物中的用途
EP4223368A4 (en) * 2020-09-30 2024-06-19 Asahi Kasei Pharma Corp MACROCYCLIC COMPOUND

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2014058691A1 (en) * 2012-10-08 2014-04-17 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
WO2014121942A1 (en) * 2013-02-07 2014-08-14 Merck Patent Gmbh Macrocyclic pyridazinone derivatives

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JP2000247959A (ja) * 1999-02-26 2000-09-12 Kowa Co ピリダジン−3−オン誘導体及びこれを含有する医薬
JP2010138073A (ja) * 2007-03-30 2010-06-24 Taisho Pharmaceutical Co Ltd ピコリン酸アミド化合物
US8703768B2 (en) * 2010-06-09 2014-04-22 Hoffmann-La Roche Inc. Nitrogen containing heteroaryl compounds
HUE032863T2 (en) * 2013-02-07 2017-11-28 Merck Patent Gmbh Piridazinonamid derivatives
US9624246B2 (en) * 2015-02-06 2017-04-18 Merck Patent Gmbh Pyridazinone macrocycles as IRAK inhibitors and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014058691A1 (en) * 2012-10-08 2014-04-17 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
WO2014121942A1 (en) * 2013-02-07 2014-08-14 Merck Patent Gmbh Macrocyclic pyridazinone derivatives

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BR112017014970A2 (pt) 2018-03-27
SG11201704651UA (en) 2017-07-28
JP6920202B2 (ja) 2021-08-18
JP2018505166A (ja) 2018-02-22
NZ732527A (en) 2022-03-25
IL253519B (en) 2021-01-31
US20160229871A1 (en) 2016-08-11
KR20170113551A (ko) 2017-10-12
CA2970550A1 (en) 2016-08-11
IL253519A0 (en) 2017-09-28
MX2017009624A (es) 2017-11-20
US10517872B2 (en) 2019-12-31
CA2970550C (en) 2023-09-19
US20170173019A1 (en) 2017-06-22
RU2708066C2 (ru) 2019-12-04
AU2016215184A1 (en) 2017-06-29
HK1246287A1 (zh) 2018-09-07
ES2841452T3 (es) 2021-07-08
KR102551597B1 (ko) 2023-07-05
RU2017130761A (ru) 2019-03-06
WO2016127024A1 (en) 2016-08-11
RU2017130761A3 (pt) 2019-07-17
AU2016215184B2 (en) 2020-11-12
BR112017014970B1 (pt) 2022-11-16
CN107428765A (zh) 2017-12-01
US9624246B2 (en) 2017-04-18
EP3253763B1 (en) 2020-09-30
EP3253763A1 (en) 2017-12-13

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