CN107427566B - Dna抗体构建体及其使用方法 - Google Patents

Dna抗体构建体及其使用方法 Download PDF

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Publication number
CN107427566B
CN107427566B CN201580075039.2A CN201580075039A CN107427566B CN 107427566 B CN107427566 B CN 107427566B CN 201580075039 A CN201580075039 A CN 201580075039A CN 107427566 B CN107427566 B CN 107427566B
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acid sequence
nucleic acid
antibody
chikv
igg
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CN107427566A (zh
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大卫·B·韦纳
卡鲁皮亚·穆图马尼
塞利克·夫林盖
尼兰詹·萨尔德赛
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University of Pennsylvania Penn
Inovio Pharmaceuticals Inc
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Inovio Pharmaceuticals Inc
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • C07K2317/00—Immunoglobulins specific features
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CN201580075039.2A 2014-12-01 2015-12-01 Dna抗体构建体及其使用方法 Active CN107427566B (zh)

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US201462086157P 2014-12-01 2014-12-01
US62/086,157 2014-12-01
US201562213166P 2015-09-02 2015-09-02
US62/213,166 2015-09-02
PCT/US2015/063174 WO2016089862A1 (en) 2014-12-01 2015-12-01 Dna antibody constructs and method of using same

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US (2) US11278619B2 (https=)
EP (1) EP3226892A4 (https=)
JP (3) JP7268958B2 (https=)
KR (1) KR20170085131A (https=)
CN (2) CN107427566B (https=)
AU (3) AU2015355126B9 (https=)
BR (1) BR112017011556A2 (https=)
CA (1) CA2969214A1 (https=)
MX (2) MX2017007187A (https=)
WO (1) WO2016089862A1 (https=)
ZA (1) ZA201703710B (https=)

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WO2015089492A2 (en) * 2013-12-13 2015-06-18 The Trustees Of The University Of Pennsylvania Dna antibody constructs and method of using same
MX2017007187A (es) * 2014-12-01 2018-01-30 Univ Pennsylvania Construcciones de anticuerpos de adn y metodo para utilizarlas.
BR112018072708A2 (pt) * 2016-05-05 2019-02-19 The Trustees Of The University Of Pennsylvania molécula de ácido nucleico, composição, e, método para tratar uma infecção por influenza em um sujeito.
BR112019005378A2 (pt) * 2016-09-19 2019-08-27 The Trustees Of The University Of Pennsylvania molécula de ácido nucleico, composição, e, métodos para prevenir ou tratar uma doença e para induzir uma resposta imune
KR20210117359A (ko) * 2016-11-07 2021-09-28 더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 라임병에 사용하기 위한 dna 항체 작제물
CN116392609A (zh) * 2017-03-23 2023-07-07 Dnarx公司 用于体内核酸表达的系统和方法
US11845787B2 (en) 2017-03-27 2023-12-19 The Wistar Institute Of Anatomy And Biology DNA antibody constructs for use against HIV
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CN110997722B (zh) * 2017-06-08 2023-09-26 黑带医疗有限公司 Cd38调节抗体
KR102770110B1 (ko) 2017-08-16 2025-02-20 블랙 벨트 테라퓨틱스 리미티드 Cd38 항체
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WO2019152599A1 (en) * 2018-01-31 2019-08-08 The Wistar Institute Of Anatomy And Biology Nucleic acid monoclonal antibodies targeting pcsk9 and methods of use
CN111253493B (zh) * 2020-03-05 2021-03-23 武汉科技大学 一种靶向hiv病毒囊膜双位点的嵌合抗原受体及其表达载体和应用
BR112022022719A2 (pt) 2020-05-14 2023-02-14 Inovio Pharmaceuticals Inc Vacinas para papilomatose respiratória recorrente e métodos de usar a mesma
CN118725096B (zh) * 2024-08-08 2025-02-07 兰州大学 一种ns1蛋白单克隆抗体及其应用

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