CN107412791A - A kind of ultrasonic wave-coupled agent of pro-skin antibacterial - Google Patents
A kind of ultrasonic wave-coupled agent of pro-skin antibacterial Download PDFInfo
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- 206010047700 Vomiting Diseases 0.000 claims abstract description 15
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- 239000002562 thickening agent Substances 0.000 claims abstract description 15
- 230000008673 vomiting Effects 0.000 claims abstract description 15
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a kind of ultrasonic wave-coupled agent of pro-skin antibacterial, belong to technical field of medicine preparation, be specifically made up of following material：Tag, monkshood, radix aconiti agrestis, vomiting nut, asarum, Chinese cassia tree, the coptis, dried peppermint leaf, moutan bark, the Chinese bulbul, lubricant, emulsifying agent, NMF, thickener, deionized water.Ultrasonic wave-coupled agent of the present invention can effectively drawout comes on skin, exclude the air of skin surface, improve imaging effect and image resolution ratio, and overall smell is small, color is light, it is easy wipe, excitant it is small, there is a good self-cleaning antibacterial, popularizing value is higher.
Description
Technical field
The invention belongs to technical field of medicine preparation, and in particular to a kind of ultrasonic wave-coupled agent of pro-skin antibacterial.
Background technology
With the development of China's science and technology, medical technology also continues to develop, and ultrasonic examination and treatment progressively turn into one
Important Clinics.During ultrasonic examination, the air between probe and patient skin will hinder ultrasonic wave to be passed to human body, to obtain
High quality image, it is necessary to fluidity transmitting medium come connect probe and the patient's body surface, this medium be exactly couplant.Ultrasound inspection
Look into and treatment is required for using couplant, coupling agent for medical use is a kind of medical production being made up of aqueous high molecular gel of new generation
Product.The quality of couplant and obtained Quality of acoustical image graphic are closely related.The couplant of poor quality can make ultrasonic energy losses, point
Power reduction is distinguished, image obscures, or even stimulates skin and damage to pop one's head in.Because ultrasonic wave-coupled agent need to directly be applied to patient skin
On, it is therefore desirable to it has good sterilizing self-cleaning function, and to reduce the cross-infection of germ etc. between patient, that adds at present is anti-
Bacterium composition has chemical agent and Chinese medicine preparation, and two kinds of compositions respectively have advantage and disadvantage, and wherein chemical agent antibiotic property is good, but to human body skin
Skin is unfavorable, the safe Small side effects of Chinese medicine preparation, but generally olfactory stimulation is strong etc., and antibacterial effect still needs to further improve.This
Outside, when ultrasonic wave-coupled agent is applied on patient skin, it will usually the stimulation such as cool, glutinous is produced to patient, especially for fear
Patient's excitant of the special constitution such as cold is bigger, is also easy to produce sense of discomfort.
The content of the invention
A kind of the present invention is intended to provide ultrasonic wave-coupled agent of pro-skin antibacterial.
The present invention is achieved through the following technical solutions：
A kind of ultrasonic wave-coupled agent of pro-skin antibacterial, is made up of the material of following parts by weight：
7 ~ 10 parts of tags, 4 ~ 8 portions of monkshoods, 3 ~ 6 portions of radix aconiti agrestis, 2 ~ 5 parts of vomiting nuts, 1 ~ 4 part of asarum, 5 ~ 8 portions of Chinese cassia trees, 12 ~ 16 parts of Huangs
Company, 2 ~ 5 parts of dried peppermint leaves, 3 ~ 6 parts of moutan barks, 1 ~ 4 portion of Chinese bulbul, 8 ~ 11 parts of lubricants, 1 ~ 1.5 part of emulsifying agent, 0.5 ~ 1 part of moisturizing
Agent, 2 ~ 3 parts of thickeners, 22 ~ 28 parts of deionized waters.
Preferably, it is made up of the material of following parts by weight：
8 parts of tags, 6 portions of monkshoods, 5 portions of radix aconiti agrestis, 3 parts of vomiting nuts, 2.5 parts of asarums, 6 portions of Chinese cassia trees, 15 portions of coptiss, 4 parts of dried peppermint leaves, 5
Part moutan bark, 3 portions of Chinese bulbuls, 9 parts of lubricants, 1.2 parts of emulsifying agents, 0.8 part of NMF, 2.5 parts of thickeners, 25 parts of deionizations
Water.
Further, described lubricant by glycerine, sodium hyaluronate, ethyl cellulose according to mass ratio 20：7：3 mixing and
Into.
Further, described emulsifying agent by polyethylene pyrrole network alkanone, sodium carboxymethylcellulose, sodium cocoyl glutamate,
At least one of cocounut oil acyl glycine potassium forms.
Further, described NMF is made up of at least one of microcrystalline wax, vaseline, soybean lecithin.
Further, described thickener is made up of at least one of Jojoba wax, beeswax, candelila wax.
A kind of preparation method of the ultrasonic wave-coupled agent of pro-skin antibacterial, comprises the following steps：
（1）First by tag, monkshood, radix aconiti agrestis, vomiting nut, asarum, Chinese cassia tree, the coptis, dried peppermint leaf, moutan bark, the Chinese bulbul respectively with clear
Water rinses rear drying for standby well；
（2）By tag, monkshood, radix aconiti agrestis, vomiting nut and asarum, mixing is put into the marmite for filling wheat bran jointly, is stirred continuously stir-frying
Taken out after 20 ~ 25min of processing, it is standby that bran stir-fry medicine is obtained after elimination wheat bran；Above-mentioned traditional Chinese medicine ingredients are put into wheat bran jointly and carry out bran
Stir-fry is handled, and can be effectively promoted the dissolution beneficial to property of medicine composition, and can reduce the content of stimulating component, has been relaxed the property of medicine, has been carried
The effect for risen its warm, stimulating circulation；
（3）By Chinese cassia tree, the coptis, dried peppermint leaf, moutan bark and the Chinese bulbul, mixing is put into the marmite for filling yellow soil jointly, is constantly stirred
Taken out after mixing 30 ~ 35min of stir-frying processing, it is standby that native stir-fry medicine is obtained after elimination yellow soil；Above-mentioned traditional Chinese medicine ingredients are put into gold zone jointly
Native stir-fry processing is carried out in soil, the dissolution beneficial to property of medicine composition can be lifted, and reduces the content of the stimulating component such as cold, is relaxed
The property of medicine, improve the effect of its antibacterial sterilizing；
（4）By step（2）The bran of gained fries medicine and step（3）The soil of gained fries medicine mixing, is put into common powder in Lowtemperaturepulverizer
It is standby that the broken mesh of mistake 100 obtains mixed powder；
（5）By step（4）The mixed powder of gained and the clear water of 5 ~ 7 times of its gross mass are blended, and boiling is filtered after boiling 1 ~ 1.5h of processing,
First-time filtrate and a filter residue it is standby, the clear water that filter residue is taken out again with 4 ~ 6 times of its gross mass is blended, processing is boiled in boiling
Filtered after 1.5 ~ 2h, it is standby to obtain secondary filtrate, then merges first-time filtrate and secondary filtrate, then carries out concentration that ointment is made is standby
With；
（6）By step（5）The same lubricant of ointment of gained, emulsifying agent, NMF, thickener, deionized water mixing are put into stirring
In machine, ultrasonic wave-coupled agent is got product after being stirred with 500 ~ 600 revs/min of rotating speed.
Further, step（2）Described in marmite temperature heating remain 110 ~ 115 DEG C.
Further, step（3）Described in marmite temperature heating remain 100 ~ 105 DEG C.
Further, step（5）Described in relative density of the ointment under the conditions of 70 DEG C be 1.00 ~ 1.05.
The present invention has the advantages that：
Antibacterial adding ingredient in ultrasonic wave-coupled agent of the present invention is plurality of Chinese extract, though Chinese medicine is widely used thousand
Year, but its effect being mutually combined can not be also known completely, on the basis of a large amount of practice proportionings, couplant of the present invention
In with the addition of described ointment composition, which use it is a variety of warm property traditional Chinese medicine ingredients, such as tag, monkshood, radix aconiti agrestis, Strychnos nux-vomica
Son, asarum, Chinese cassia tree etc., the use of mentioned component can be effectively promoted skin blood circulation, lift the temperature that place's skin is wiped by painting,
Reducing its sense of discomfort, the coptis of addition, dried peppermint leaf, moutan bark, Chinese bulbul etc. can effectively strengthen the drug effect of remaining medicinal ingredient,
The use of overall antibacterial effect and sterilizing range, cooperation lubricant, emulsifying agent, NMF, thickener etc. is lifted, the present invention is super
Sound wave couplant can effectively drawout comes on skin, excludes the air of skin surface, improves imaging effect and image point
Resolution, and overall smell is small, color is light, it is easy wipe, excitant it is small, have a good self-cleaning antibacterial, popularizing value compared with
It is high.
Embodiment
Embodiment 1
A kind of ultrasonic wave-coupled agent of pro-skin antibacterial, is made up of the material of following parts by weight：
7 parts of tags, 4 portions of monkshoods, 3 portions of radix aconiti agrestis, 2 parts of vomiting nuts, 1 part of asarum, 5 portions of Chinese cassia trees, 12 portions of coptiss, 2 parts of dried peppermint leaves, 3 parts
Moutan bark, 1 portion of Chinese bulbul, 8 parts of lubricants, 1 part of emulsifying agent, 0.5 part of NMF, 2 parts of thickeners, 22 parts of deionized waters.
Further, described lubricant by glycerine, sodium hyaluronate, ethyl cellulose according to mass ratio 20：7：3 mixing and
Into.
Further, described emulsifying agent is made up of polyethylene pyrrole network alkanone, sodium carboxymethylcellulose.
Further, described NMF is made up of microcrystalline wax, vaseline, soybean lecithin.
Further, described thickener is made up of Jojoba wax, beeswax.
A kind of preparation method of the ultrasonic wave-coupled agent of pro-skin antibacterial, comprises the following steps：
（1）First by tag, monkshood, radix aconiti agrestis, vomiting nut, asarum, Chinese cassia tree, the coptis, dried peppermint leaf, moutan bark, the Chinese bulbul respectively with clear
Water rinses rear drying for standby well；
（2）By tag, monkshood, radix aconiti agrestis, vomiting nut and asarum, mixing is put into the marmite for filling wheat bran jointly, is stirred continuously stir-frying
Taken out after processing 23min, it is standby that bran stir-fry medicine is obtained after elimination wheat bran；
（3）By Chinese cassia tree, the coptis, dried peppermint leaf, moutan bark and the Chinese bulbul, mixing is put into the marmite for filling yellow soil jointly, is constantly stirred
Taken out after mixing stir-frying processing 32min, it is standby that native stir-fry medicine is obtained after elimination yellow soil；
（4）By step（2）The bran of gained fries medicine and step（3）The soil of gained fries medicine mixing, is put into common powder in Lowtemperaturepulverizer
It is standby that the broken mesh of mistake 100 obtains mixed powder；
（5）By step（4）The mixed powder of gained and the clear water of 6 times of its gross mass are blended, and boiling is filtered after boiling processing 1.3h, obtains one
Secondary filtrate and a filter residue are standby, the clear water that filter residue is taken out again with 5 times of its gross mass are blended, mistake after processing 1.8h is boiled in boiling
Filter, it is standby to obtain secondary filtrate, then merges first-time filtrate and secondary filtrate, then carries out concentration that ointment is made is standby；
（6）By step（5）The same lubricant of ointment of gained, emulsifying agent, NMF, thickener, deionized water mixing are put into stirring
In machine, ultrasonic wave-coupled agent is got product after being stirred with 500 ~ 550 revs/min of rotating speed.
Further, step（2）Described in marmite temperature heating remain 110 ~ 115 DEG C.
Further, step（3）Described in marmite temperature heating remain 100 ~ 105 DEG C.
Further, step（5）Described in relative density of the ointment under the conditions of 70 DEG C be 1.00 ~ 1.03.
Embodiment 2
A kind of ultrasonic wave-coupled agent of pro-skin antibacterial, is made up of the material of following parts by weight：
8 parts of tags, 6 portions of monkshoods, 5 portions of radix aconiti agrestis, 3 parts of vomiting nuts, 2.5 parts of asarums, 6 portions of Chinese cassia trees, 15 portions of coptiss, 4 parts of dried peppermint leaves, 5
Part moutan bark, 3 portions of Chinese bulbuls, 9 parts of lubricants, 1.2 parts of emulsifying agents, 0.8 part of NMF, 2.5 parts of thickeners, 25 parts of deionizations
Water.Remaining method and step is the same as embodiment 1.
Embodiment 3
A kind of ultrasonic wave-coupled agent of pro-skin antibacterial, is made up of the material of following parts by weight：
10 parts of tags, 8 portions of monkshoods, 6 portions of radix aconiti agrestis, 5 parts of vomiting nuts, 4 parts of asarums, 8 portions of Chinese cassia trees, 16 portions of coptiss, 5 parts of dried peppermint leaves, 6 parts
Moutan bark, 4 portions of Chinese bulbuls, 11 parts of lubricants, 1.5 parts of emulsifying agents, 1 part of NMF, 3 parts of thickeners, 28 parts of deionized waters.Remaining
Method and step is the same as embodiment 1.
Comparative example 1
This comparative example 1 compared with Example 1, does not contain monkshood and vomiting nut in its composition, method and step in addition is equal
It is identical.
Comparative example 2
This comparative example 2 compared with Example 2, does not contain moutan bark and the Chinese bulbul in its composition, method and step in addition
All same.
Comparative example 3
This comparative example 3 compared with Example 3, in preparation process, saves step（2）Bran fry processing and step（3）'s
Native stir-fry processing, method and step all same in addition.
Control group
The existing ultrasonic wave-coupled agent using traditional Chinese medicine ingredients as antibacterial additives.
In order to contrast effect of the present invention, sterilization experiment, skin are carried out to ultrasonic wave-coupled agent corresponding to above-mentioned several ways
Irritant experiment and patient（People）Body-sensing is tested.
Wherein described sterilization experiment is specifically：Using carrier quantitative germicidal test method, tried under the conditions of 20 DEG C
Test.Experiment is divided in sterilized petri dishes with ultrasonic wave-coupled agent by each ml dosages of bacterium piece 5.0, bacterium piece is fully immersed in
In ultrasonic wave-coupled agent, act on to the stipulated time, take out bacterium piece and put into the test tube equipped with 5.0 ml nertralizers, neutralization
Eluted after 10 min through fully shaking, take eluent inoculated and cultured, carry out count plate, logarithm value is averagely killed in calculating.
Described skin irritation test is specifically：Regular grade New Zealand White rabbit 7 is selected, will before 24 h of experiment
Each 3cm × 3cm scopes of back part of animal backbone both sides unhairing.0.5 ml ultrasonic wave-coupleds agent is taken to smear on the skin of unhairing of side, separately
Side compares.After smearing 4 h, warm water washes away couplant residue, repeats 1 time daily, continuous 14 d.After smearing 24 h
Start to observe dermoreaction, integrated and judged stimulus intensity index according to specification grade scale.
Described patient（People）Body-sensing is tested：Ultrasonic wave-coupled agent is to volunteer corresponding to above-mentioned seven kinds of modes
Ultrasonic examination experience operation is carried out with this, counts patient's body-sensing state, with 5 member records, the bigger experience for representing skin of numerical value
Sense is better, couplant olfactory stimulation is smaller.
Table 1 below is the correction data of each group sterilization experiment：
Table 1
The present invention is preferable for the killing effect of a variety of germs it can be seen from upper table 1, and antibiotic property is wide, improves to human body
The protection domain of health.
Foundation《Disinfection technology standard》Standards of grading, found when the skin irritation test result to each group counts, respectively
The equal ＜ 0.5 of highest skin irritation index in group, i.e. stimulus intensity belong to nonirritant, met the requirements.
Table 2 below is the correction data of each group body-sensing experiment：
Table 2
| Body-sensing scores（Point） | |
| Embodiment 1 | 4.3 |
| Embodiment 2 | 4.4 |
| Embodiment 3 | 4.2 |
| Comparative example 1 | 3.9 |
| Comparative example 2 | 4.1 |
| Comparative example 3 | 3.8 |
| Control group | 3.6 |
Ultrasonic wave-coupled agent of the present invention is smaller for human body skin and the excitant of smell it can be seen from upper table 2, with more pushing away
Wide use value.
Claims (10)
1. a kind of ultrasonic wave-coupled agent of pro-skin antibacterial, it is characterised in that be made up of the material of following parts by weight：
7 ~ 10 parts of tags, 4 ~ 8 portions of monkshoods, 3 ~ 6 portions of radix aconiti agrestis, 2 ~ 5 parts of vomiting nuts, 1 ~ 4 part of asarum, 5 ~ 8 portions of Chinese cassia trees, 12 ~ 16 parts of Huangs
Company, 2 ~ 5 parts of dried peppermint leaves, 3 ~ 6 parts of moutan barks, 1 ~ 4 portion of Chinese bulbul, 8 ~ 11 parts of lubricants, 1 ~ 1.5 part of emulsifying agent, 0.5 ~ 1 part of moisturizing
Agent, 2 ~ 3 parts of thickeners, 22 ~ 28 parts of deionized waters.
2. the ultrasonic wave-coupled agent of a kind of pro-skin antibacterial according to claim 1, it is characterised in that by following parts by weight
Material is made：
8 parts of tags, 6 portions of monkshoods, 5 portions of radix aconiti agrestis, 3 parts of vomiting nuts, 2.5 parts of asarums, 6 portions of Chinese cassia trees, 15 portions of coptiss, 4 parts of dried peppermint leaves, 5
Part moutan bark, 3 portions of Chinese bulbuls, 9 parts of lubricants, 1.2 parts of emulsifying agents, 0.8 part of NMF, 2.5 parts of thickeners, 25 parts of deionizations
Water.
A kind of 3. ultrasonic wave-coupled agent of pro-skin antibacterial according to claim 1 or 2, it is characterised in that described lubrication
Agent is by glycerine, sodium hyaluronate, ethyl cellulose according to mass ratio 20：7：3 mix.
A kind of 4. ultrasonic wave-coupled agent of pro-skin antibacterial according to claim 1 or 2, it is characterised in that described emulsification
Agent is by least one of polyethylene pyrrole network alkanone, sodium carboxymethylcellulose, sodium cocoyl glutamate, cocounut oil acyl glycine potassium group
Into.
A kind of 5. ultrasonic wave-coupled agent of pro-skin antibacterial according to claim 1 or 2, it is characterised in that described moisturizing
Agent is made up of at least one of microcrystalline wax, vaseline, soybean lecithin.
A kind of 6. ultrasonic wave-coupled agent of pro-skin antibacterial according to claim 1 or 2, it is characterised in that described thickening
Agent is made up of at least one of Jojoba wax, beeswax, candelila wax.
A kind of 7. preparation method of the ultrasonic wave-coupled agent of pro-skin antibacterial as claimed in claim 1 or 2, it is characterised in that bag
Include following steps：
（1）First by tag, monkshood, radix aconiti agrestis, vomiting nut, asarum, Chinese cassia tree, the coptis, dried peppermint leaf, moutan bark, the Chinese bulbul respectively with clear
Water rinses rear drying for standby well；
（2）By tag, monkshood, radix aconiti agrestis, vomiting nut and asarum, mixing is put into the marmite for filling wheat bran jointly, is stirred continuously stir-frying
Taken out after 20 ~ 25min of processing, it is standby that bran stir-fry medicine is obtained after elimination wheat bran；
（3）By Chinese cassia tree, the coptis, dried peppermint leaf, moutan bark and the Chinese bulbul, mixing is put into the marmite for filling yellow soil jointly, is constantly stirred
Taken out after mixing 30 ~ 35min of stir-frying processing, it is standby that native stir-fry medicine is obtained after elimination yellow soil；
（4）By step（2）The bran of gained fries medicine and step（3）The soil of gained fries medicine mixing, is put into common powder in Lowtemperaturepulverizer
It is standby that the broken mesh of mistake 100 obtains mixed powder；
（5）By step（4）The mixed powder of gained and the clear water of 5 ~ 7 times of its gross mass are blended, and boiling is filtered after boiling 1 ~ 1.5h of processing,
First-time filtrate and a filter residue it is standby, the clear water that filter residue is taken out again with 4 ~ 6 times of its gross mass is blended, processing is boiled in boiling
Filtered after 1.5 ~ 2h, it is standby to obtain secondary filtrate, then merges first-time filtrate and secondary filtrate, then carries out concentration that ointment is made is standby
With；
（6）By step（5）The same lubricant of ointment of gained, emulsifying agent, NMF, thickener, deionized water mixing are put into stirring
In machine, ultrasonic wave-coupled agent is got product after being stirred with 500 ~ 600 revs/min of rotating speed.
A kind of 8. preparation method of the ultrasonic wave-coupled agent of pro-skin antibacterial according to claim 7, it is characterised in that step
（2）Described in marmite temperature heating remain 110 ~ 115 DEG C.
A kind of 9. preparation method of the ultrasonic wave-coupled agent of pro-skin antibacterial according to claim 7, it is characterised in that step
（3）Described in marmite temperature heating remain 100 ~ 105 DEG C.
A kind of 10. preparation method of the ultrasonic wave-coupled agent of pro-skin antibacterial according to claim 7, it is characterised in that step
Suddenly（5）Described in relative density of the ointment under the conditions of 70 DEG C be 1.00 ~ 1.05.
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| CN103341184A (en) * | 2013-07-31 | 2013-10-09 | 王玉梅 | Ultrasonic coupling agent and preparation method thereof |
| CN105194697A (en) * | 2015-11-05 | 2015-12-30 | 济宁博联生物科技有限公司 | Medical ultrasonic coupling agent and preparation method thereof |
| CN105536003A (en) * | 2015-12-26 | 2016-05-04 | 江雨珊 | Coupling agent for B ultrasound |
| CN105944119A (en) * | 2016-06-23 | 2016-09-21 | 孙百梅 | Coupling lubricating solution for B ultrasonic examination |
| CN106039330A (en) * | 2016-06-16 | 2016-10-26 | 吉林医药学院 | Antibacterial medical ultrasonic coupling agent containing traditional Chinese medicine ingredients and preparation method thereof |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103341184A (en) * | 2013-07-31 | 2013-10-09 | 王玉梅 | Ultrasonic coupling agent and preparation method thereof |
| CN105194697A (en) * | 2015-11-05 | 2015-12-30 | 济宁博联生物科技有限公司 | Medical ultrasonic coupling agent and preparation method thereof |
| CN105536003A (en) * | 2015-12-26 | 2016-05-04 | 江雨珊 | Coupling agent for B ultrasound |
| CN106039330A (en) * | 2016-06-16 | 2016-10-26 | 吉林医药学院 | Antibacterial medical ultrasonic coupling agent containing traditional Chinese medicine ingredients and preparation method thereof |
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Application publication date: 20171201 |