CN107412507A - A kind of Chinese medicine composition for treating hypertension and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating hypertension and preparation method thereof Download PDFInfo
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- CN107412507A CN107412507A CN201710168824.3A CN201710168824A CN107412507A CN 107412507 A CN107412507 A CN 107412507A CN 201710168824 A CN201710168824 A CN 201710168824A CN 107412507 A CN107412507 A CN 107412507A
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Abstract
The invention discloses a kind of Chinese medicine composition for treating hypertension, including ginseng, the Radix Astragali, RADIX ANGELICAE SINEINSIS, the root of herbaceous peony, radix bupleuri, Poria cocos, peppermint, yellow tag, Chinese cassia tree, Fructus Corni, the bark of eucommia, Semen Cuscutae, cultivated land, Chinese yam rhizome, matrimony vine, the thick stick of sika deer velvet antler two, spina date seed, the dried immature fruit of citron orange, the bighead atractylodes rhizome and fructus gardeniae.The invention also discloses a kind of preparation method for the Chinese medicine composition for treating hypertension.It can be effectively depressured, and the property of medicine is gentle, and adverse reaction and side effect will not be produced after taking；Preparation method is simple, short preparation period, suitable for large-scale production and personal preparation.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition for treating hypertension and preparation method thereof.
Background technology
Hypertension refers in the case of unused antihypertensive, systolic pressure >=140mmHg and/or diastolic pressure >=90mmHg,
Hypertension is divided into 1 grade (diastolic pressure 90~99 of systolic pressure 140~159), 2 grades of (diastoles of systolic pressure 160~179 by blood pressure level
Pressure 100~109), 3 grades (systolic pressures >=180 diastolic pressure >=110), systolic pressure >=140mmHg and diastolic pressure<90mmHg is single-row to be
Isolated systolic hypertension.Patient previously has history of hypertension, currently with antihypertensive, although blood pressure is less than 140/
90mmHg, it should also be diagnosed as hypertension.
The symptom of high blood pressure, often because of people, because of stadium and different.Early stage how asymptomatic or symptom unobvious, it is even in physique
Check or due to being found during other reason measuring blood pressures.Common symptom has：Dizziness, headache, agitation, palpitaition, insomnia, notice are not
Concentration, failure of memory, extremity numbness, nosebleed, conjunctival hemorrhage, fundus hemorrhage, cerebral hemorrhage etc..
Treatment method is according to state of an illness reasonable employment antihypertensive drugs mostly at present, maintains blood pressure normal or close to normal water
It is flat, to mitigating symptom, delay disease progression and prevent the complication such as cerebrovas-cularaccident, heart failure and renal failure from having
Effect.Antihypertensive drugs species is a lot, respectively has its feature, is intended to persistent at present, take number reduction durative action preparation or
Formulation, to facilitate clothes for patients to use.Conventional antihypertensive drugs has：
1st, diuretic hypotensive agent：Hydrochioro, cyclopenthiazide, chlorthalidone, furosemide etc..
2nd, nervous centralis and sympathetic inhibitor：Reserpine, verticilum, clonidine hydrochloride.
3rd, stagnant dose of adrenergic receptor group：Beta-blocker such as inderal, atenolol and Metoprolol etc.；Alpha blocker
As benzylamine, alpha+beta retarding agent such as willow ammonia benzyl are felt at ease.
4th, enzyme inhibitor such as angiotensin converting enzyme inhibitor such as captopril, enalapril etc..
5th, calcium ion antagonist such as nifedipine, Amlodipine etc..
6th, vasodilator such as hydralazine, minoxidil, prazosin, croak cyanogen pyridine etc..
7th, sympathetic inhibitor such as guanethidine, the first croak pyridine of tartaric acid five etc. after neuromere and section.
8th, 5-hydroxytryptamine receptor antagonist such as ketanserin etc..
9th, compound preparation such as Compound Reserpine, FUFANG LUOBUMA PIAN, Adelgerpin etc..
Western medicine in terms of hypertension is treated using more, still, there is also serious adverse reaction and side effect, if any
Medicine can influence water and electrolyte metabolism, influence blood fat, metabolism of blood glucose, and some medicine long-term uses can also affect on sexual function etc.；Together
When, fluctuation of blood pressure is larger in pressure reduction, particularly early stage or senile hypertension, very sensitive to Western medicine depressor, and one uses
Medicine blood pressure may be fallen too low, or even postural hypotension occurs, and reducing dosage or number, blood pressure may rise quickly again
It is high.Symptom improvement result is not so good as Chinese medicine, and many patients are reduced to normally with blood pressure after Western medicine, and subjective symptoms is still fairly obvious.
The medicine antihypertensive effect unobvious of existing treatment hypertension, and general price is all more expensive；Patient is long-term use of
Afterwards, there is also certain adverse reaction and side effect；And preparation technology is often very complicated, long preparation period is cost-effective
Treatment hypertension drug can not be produced largely, cause medicine more and more expensive, therapeutic effect cannot also improve.
The content of the invention
Based on this, for above-mentioned, it is necessary to propose a kind of Chinese medicine composition for treating hypertension and preparation method thereof, its energy
Effectively decompression, and the raw material in formula is cheap, the property of medicine is gentle, and adverse reaction and side effect will not be produced after taking；Preparation method
Simply, short preparation period, suitable for large-scale production and personal preparation.
The present invention provides a kind of Chinese medicine composition for treating hypertension, and its technical scheme is as follows：
A kind of Chinese medicine composition for treating hypertension, including ginseng, the Radix Astragali, RADIX ANGELICAE SINEINSIS, the root of herbaceous peony, radix bupleuri, Poria cocos, peppermint,
Yellow tag, Chinese cassia tree, Fructus Corni, the bark of eucommia, Semen Cuscutae, cultivated land, Chinese yam rhizome, matrimony vine, the thick stick of sika deer velvet antler two, spina date seed, the dried immature fruit of citron orange, the bighead atractylodes rhizome
And fructus gardeniae, wherein, the components by weight percent ratio of each composition is：
Ginseng 4-6 parts, Radix Astragali 4-6 parts, RADIX ANGELICAE SINEINSIS 7-8 parts, root of herbaceous peony 6-8 parts, radix bupleuri 6-8 parts, Poria cocos 6-8 parts, peppermint 6-8
Part, yellow tag 2-3 parts, Chinese cassia tree 2-3 parts, Fructus Corni 4-6 parts, bark of eucommia 4-6 parts, Semen Cuscutae 4-6 parts, cultivated land 6-8 parts, Chinese yam rhizome 4-
6 parts, matrimony vine 6-8 parts, the thick stick 2-4 parts of sika deer velvet antler two, spina date seed 6-8 parts, dried immature fruit of citron orange 4-6 parts, bighead atractylodes rhizome 6-8 parts, fructus gardeniae 4-6 parts.
Showed according to hypertension, be the potential deficiency of the kidney yin often with renal damage in early days based on the high Sheng of liver-yang, kidney
Essence is not solid.Therefore the root of herbaceous peony and radix bupleuri in we have the effect of nourishing the liver, soothing the liver, cultivated land, Semen Cuscutae, the bark of eucommia and Fructus Corni mixing system
Medicine, can enriching yin and nourishing kidney, as monarch drug in a prescription；It is equipped with peppermint auxiliary radix bupleuri and carries out soothing the liver, the thick stick of sika deer velvet antler two and matrimony vine, which have, fills up kidney
The effect of smart, as ministerial drug, the effect of strengthening monarch drug in a prescription；Meanwhile ginseng and the Radix Astragali have the effect of tonifying Qi, RADIX ANGELICAE SINEINSIS is used to go
Gas is enriched blood, Poria cocos and the bighead atractylodes rhizome have the effect of dehumidifying sharp water, yellow tag and Chinese cassia tree with the use of can temperature sun mend and lose, sensible four limbs,
Chinese yam rhizome can invigorating spleen and reinforcing stomach, nourishing kidney and replenishing pneuma, reduce blood glucose, spina date seed has the effect of mental-tranquilization, the dried immature fruit of citron orange can relieving stagnant Qi disperse accumulations, change
Phlegm dissipates ruffian, fructus gardeniae protect liver, heat-clearing, purging intense heat, as making medicine.
It after above material medicine compatibility, can play a part of filling blood, nourishing and strengthening vital, dispersing stagnated hepatoqi and feel at ease to repose,
The vital organs of the human body can all be looked after, and make painstaking effort enlargement of pipe and reach the purpose to reduce blood pressure.
As the further optimization of such scheme, the components by weight percent ratio of each composition is：
4 parts of ginseng, 4 parts of the Radix Astragali, 7 parts of RADIX ANGELICAE SINEINSIS, 6 parts of the root of herbaceous peony, 6 parts of radix bupleuri, 6 parts of Poria cocos, 6 parts of peppermint, 2 parts of yellow tag,
2 parts of Chinese cassia tree, 4 parts of Fructus Corni, 4 parts of the bark of eucommia, 4 parts of Semen Cuscutae, 6 parts of cultivated land, 4 parts of Chinese yam rhizome, 6 parts of matrimony vine, the thick stick 2 of sika deer velvet antler two
Part, 6 parts of spina date seed, 4 parts of the dried immature fruit of citron orange, 6 parts of the bighead atractylodes rhizome, 4 parts of fructus gardeniae.
As the further optimization of such scheme, the components by weight percent ratio of each composition is：
5 parts of ginseng, 5 parts of the Radix Astragali, 7 parts of RADIX ANGELICAE SINEINSIS, 7 parts of the root of herbaceous peony, 7 parts of radix bupleuri, 7 parts of Poria cocos, 7 parts of peppermint, yellow tag 2.5
Part, 2.5 parts of Chinese cassia tree, 5 parts of Fructus Corni, 5 parts of the bark of eucommia, 5 parts of Semen Cuscutae, 7 parts of cultivated land, 5 parts of Chinese yam rhizome, 7 parts of matrimony vine, sika deer velvet antler two
3 parts of thick stick, 7 parts of spina date seed, 5 parts of the dried immature fruit of citron orange, 7 parts of the bighead atractylodes rhizome, 5 parts of fructus gardeniae.
As the further optimization of such scheme, the components by weight percent ratio of each composition is：
6 parts of ginseng, 6 parts of the Radix Astragali, 8 parts of RADIX ANGELICAE SINEINSIS, 8 parts of the root of herbaceous peony, 8 parts of radix bupleuri, 8 parts of Poria cocos, 8 parts of peppermint, 3 parts of yellow tag,
3 parts of Chinese cassia tree, 6 parts of Fructus Corni, 6 parts of the bark of eucommia, 6 parts of Semen Cuscutae, 8 parts of cultivated land, 6 parts of Chinese yam rhizome, 8 parts of matrimony vine, the thick stick 4 of sika deer velvet antler two
Part, 8 parts of spina date seed, 6 parts of the dried immature fruit of citron orange, 8 parts of the bighead atractylodes rhizome, 6 parts of fructus gardeniae.
As the further optimization of such scheme, the Chinese medicine composition is dissipates, tablet, pill, capsule, particle
Agent, honey pill agent or oral liquid.
According to patient's different demands, hobby, different types of medicament can be fabricated to, its content composition is identical.
It is above-described treatment hypertension Chinese medicine composition usage and dosage be：Chew clothes on an empty stomach, one day two ball, daily
Sooner or later each ball；After blood pressure drops to normal level, one day ball or two balls；It is preferably long-term use of.
The present invention can be used for treating various hypertension symptoms, including essential hypertension, secondary hypertension and not clear
The hypertension of reason；Meanwhile prevent the angiocardiopathies such as cerebral embolism, cerebral hemorrhage, headstroke；It is cold, small that chilly, limb can also be improved
Just the physiological problem such as clear length, loose stool.
Present invention also offers a kind of preparation method for the Chinese medicine composition for treating hypertension, its technical scheme are as follows：
A kind of preparation method of the Chinese medicine composition of the hypertension for the treatment of as claimed in claim 1, comprises the following steps：
A, choose ginseng 4-6 parts, Radix Astragali 4-6 parts, RADIX ANGELICAE SINEINSIS 7-8 parts, root of herbaceous peony 6-8 parts, radix bupleuri 6-8 parts, Poria cocos 6-8 parts,
Peppermint 6-8 parts, yellow tag 2-3 parts, Chinese cassia tree 2-3 parts, Fructus Corni 4-6 parts, bark of eucommia 4-6 parts, Semen Cuscutae 4-6 parts, cultivated land 6-8 parts,
Chinese yam rhizome 4-6 parts, matrimony vine 6-8 parts, the thick stick 2-4 parts of sika deer velvet antler two, spina date seed 6-8 parts and dried immature fruit of citron orange 4-6 parts, go the removal of impurity respectively,
Shred, dry, and according to setting components by weight percent ratio weigh it is rear standby；
B, it will be mixed well in step a according to the components by weight percent of setting than weighing rear standby bulk drug mixing, and add water
For the pure water of all 10-12 times of bulk drug weight summations, immersion is boiled by fire after 30 minutes, and then it is small to decoct 1-2 again for slow fire
When, filtering, obtain the first filtrate and the first filter residue；
C, the first filter residue is added into the pure water that water is the first 5-10 times of filter residue weight summation again, after soaking 30 minutes
It is boiled by fire, then slow fire decocts 0.5-1.5 hours again, filtering, obtains the second filtrate and the second filter residue, and by the second of gained
Filtrate merges into the 3rd filtrate with the first filtrate；
D, by the bighead atractylodes rhizome of 6-8 parts by weight and the fructus gardeniae stir-bake to yellowish of 4-6 parts by weight, after the bighead atractylodes rhizome and stir-bake to yellowish after stir-bake to yellowish
After fructus gardeniae is cooled to normal temperature, take out；
E, the bighead atractylodes rhizome after stir-bake to yellowish, the fructus gardeniae after stir-bake to yellowish and the second filter residue are mixed and mixed well, and add water as this three kinds
The pure water of 8-10 times of bulk drug weight summation soaks 30 minutes, and slow fire decocts 0.5-1 hours again after being boiled by fire, and filtering, obtains
To the 4th filtrate；
F, the 3rd filtrate and the 4th filtrate are mixed to get total filtrate.
G, it is relative density 1.20- to concentrate total filtrate in step f in the environment of 60 DEG C, vacuum 0.08Mpa
1.30 concentrate.
It will be used as medicine after bighead atractylodes rhizome stir-bake to yellowish, because the preparation method of the bighead atractylodes rhizome is different, effect is also difference, white compared to raw
Art, rhizoma atractylodis macrocephalae have strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, it is antiabortive the effect of；It will be used as medicine after fructus gardeniae stir-bake to yellowish, there is protect liver, profit
Courage, decompression, calmness, hemostasis, the effect of detumescence.The bighead atractylodes rhizome and fructus gardeniae after stir-bake to yellowish should not boil long, therefore be mixed with the second filter residue
Decoct afterwards and be advantageous to keep drug effect.
It is further comprising the steps of as the further optimization of such scheme：
The concentrate in step g is taken, adds one or both of the starch, dextrin or lactose of 2-5 times of weight of concentrate,
Using thick paste granulation, pelletized, dried at 50 DEG C -70 DEG C, whole grain, obtain granule.
It is further comprising the steps of as the further optimization of such scheme：
The concentrate in step g is taken, adds pure water dilution, and is bottled, then obtains oral liquid.
It is further comprising the steps of as the further optimization of such scheme：
The concentrate in step g is taken, adds one or both of the starch, dextrin and lactose of 2-5 times of weight of concentrate,
Using thick paste granulation, pelletized, dried at 50 DEG C -70 DEG C, whole grain obtains particle, and quiet particulate abrasive loads into powder
In capsule, capsule is both obtained.
It is further comprising the steps of as the further optimization of such scheme：
The concentrate in step g is taken, adds one or both of the starch, dextrin and lactose of 2-5 times of weight of concentrate,
Using thick paste granulation, pelletized, dried at 50 DEG C -70 DEG C, whole grain, obtain particle；Add particle weight 0.5%-1%
Magnesium stearate, be well mixed with particle, tabletting, both tablet.
The beneficial effects of the invention are as follows：
1st, reasonable compatibility between each bulk drug in the present invention, the effect of making each medicine, produce synergy, adjust heart
Function, make painstaking effort enlargement of pipe and reach the purpose to reduce blood pressure, there is the effect of fine for treatment hypertension.
2nd, raw material is cheap, and the property of medicine is gentle, securely and reliably, adverse reaction and side effect will not be produced after taking.
3rd, preparation method is simple, effective, short preparation period, is not only suitable for large-scale production, is adapted to individual making again.
4th, the present invention can be used for treating various hypertension symptoms, including essential hypertension, secondary hypertension and not
The hypertension of bright reason；Meanwhile it can also prevent the angiocardiopathies such as cerebral embolism, cerebral hemorrhage, headstroke；Chilly, limb can also be improved
The physiological problems such as cold, clear abundant urine, loose stool.
5th, different types of medicament can be fabricated to, its content composition is identical, meets the different demands and hobby of patient.
Embodiment
Embodiments of the invention are described in detail below.
Embodiment 1
A kind of Chinese medicine composition for treating hypertension, by ginseng, the Radix Astragali, RADIX ANGELICAE SINEINSIS, the root of herbaceous peony, radix bupleuri, Poria cocos, peppermint, Huang
Tag, Chinese cassia tree, Fructus Corni, the bark of eucommia, Semen Cuscutae, cultivated land, Chinese yam rhizome, matrimony vine, the thick stick of sika deer velvet antler two, spina date seed, the dried immature fruit of citron orange, the bighead atractylodes rhizome and
Fructus gardeniae forms, wherein, the components by weight percent ratio of each composition is：
4 parts of ginseng, 4 parts of the Radix Astragali, 7 parts of RADIX ANGELICAE SINEINSIS, 6 parts of the root of herbaceous peony, 6 parts of radix bupleuri, 6 parts of Poria cocos, 6 parts of peppermint, 2 parts of yellow tag,
2 parts of Chinese cassia tree, 4 parts of Fructus Corni, 4 parts of the bark of eucommia, 4 parts of Semen Cuscutae, 6 parts of cultivated land, 4 parts of Chinese yam rhizome, 6 parts of matrimony vine, the thick stick 2 of sika deer velvet antler two
Part, 6 parts of spina date seed, 4 parts of the dried immature fruit of citron orange, 6 parts of the bighead atractylodes rhizome, 4 parts of fructus gardeniae.
Embodiment 2
A kind of Chinese medicine composition for treating hypertension, by ginseng, the Radix Astragali, RADIX ANGELICAE SINEINSIS, the root of herbaceous peony, radix bupleuri, Poria cocos, peppermint, Huang
Tag, Chinese cassia tree, Fructus Corni, the bark of eucommia, Semen Cuscutae, cultivated land, Chinese yam rhizome, matrimony vine, the thick stick of sika deer velvet antler two, spina date seed, the dried immature fruit of citron orange, the bighead atractylodes rhizome and
Fructus gardeniae forms, wherein, the components by weight percent ratio of each composition is：
6 parts of ginseng, 6 parts of the Radix Astragali, 8 parts of RADIX ANGELICAE SINEINSIS, 8 parts of the root of herbaceous peony, 8 parts of radix bupleuri, 8 parts of Poria cocos, 8 parts of peppermint, 3 parts of yellow tag,
3 parts of Chinese cassia tree, 6 parts of Fructus Corni, 6 parts of the bark of eucommia, 6 parts of Semen Cuscutae, 8 parts of cultivated land, 6 parts of Chinese yam rhizome, 8 parts of matrimony vine, the thick stick 4 of sika deer velvet antler two
Part, 8 parts of spina date seed, 6 parts of the dried immature fruit of citron orange, 8 parts of the bighead atractylodes rhizome, 6 parts of fructus gardeniae.
The Chinese medicine composition is powder.
Embodiment 3
A kind of Chinese medicine composition for treating hypertension, by ginseng, the Radix Astragali, RADIX ANGELICAE SINEINSIS, the root of herbaceous peony, radix bupleuri, Poria cocos, peppermint, Huang
Tag, Chinese cassia tree, Fructus Corni, the bark of eucommia, Semen Cuscutae, cultivated land, Chinese yam rhizome, matrimony vine, the thick stick of sika deer velvet antler two, spina date seed, the dried immature fruit of citron orange, the bighead atractylodes rhizome and
Fructus gardeniae forms, wherein, the components by weight percent ratio of each composition is：
5 parts of ginseng, 5 parts of the Radix Astragali, 7 parts of RADIX ANGELICAE SINEINSIS, 7 parts of the root of herbaceous peony, 7 parts of radix bupleuri, 7 parts of Poria cocos, 7 parts of peppermint, yellow tag 2.5
Part, 2.5 parts of Chinese cassia tree, 5 parts of Fructus Corni, 5 parts of the bark of eucommia, 5 parts of Semen Cuscutae, 7 parts of cultivated land, 5 parts of Chinese yam rhizome, 7 parts of matrimony vine, sika deer velvet antler two
3 parts of thick stick, 7 parts of spina date seed, 5 parts of the dried immature fruit of citron orange, 7 parts of the bighead atractylodes rhizome, 5 parts of fructus gardeniae.
The Chinese medicine composition is tablet.
Embodiment 4
A kind of Chinese medicine composition for treating hypertension, by ginseng, the Radix Astragali, RADIX ANGELICAE SINEINSIS, the root of herbaceous peony, radix bupleuri, Poria cocos, peppermint, Huang
Tag, Chinese cassia tree, Fructus Corni, the bark of eucommia, Semen Cuscutae, cultivated land, Chinese yam rhizome, matrimony vine, the thick stick of sika deer velvet antler two, spina date seed, the dried immature fruit of citron orange, the bighead atractylodes rhizome and
Fructus gardeniae forms, wherein, the components by weight percent ratio of each composition is：
55 grams of ginseng, 55 grams of the Radix Astragali, 72 grams of RADIX ANGELICAE SINEINSIS, 70 grams of the root of herbaceous peony, 70 grams of radix bupleuri, 70 grams of Poria cocos, 70 grams of peppermint, Huang are attached
28 grams of piece, 28 grams of Chinese cassia tree, 56 grams of Fructus Corni, 55 grams of the bark of eucommia, 55 grams of Semen Cuscutae, 75 grams of cultivated land, 55 grams of Chinese yam rhizome, 75 grams of matrimony vine,
35 grams of two thick stick of sika deer velvet antler, 76 grams of spina date seed, 56 grams of the dried immature fruit of citron orange, 75 grams of the bighead atractylodes rhizome, 55 grams of fructus gardeniae.
The Chinese medicine composition is granule.
Embodiment 5
A kind of Chinese medicine composition for treating hypertension, by ginseng, the Radix Astragali, RADIX ANGELICAE SINEINSIS, the root of herbaceous peony, radix bupleuri, Poria cocos, peppermint, Huang
Tag, Chinese cassia tree, Fructus Corni, the bark of eucommia, Semen Cuscutae, cultivated land, Chinese yam rhizome, matrimony vine, the thick stick of sika deer velvet antler two, spina date seed, the dried immature fruit of citron orange, the bighead atractylodes rhizome and
Fructus gardeniae forms, and each group is divided into：
Ginseng 500g, Radix Astragali 500g, RADIX ANGELICAE SINEINSIS 700g, root of herbaceous peony 750g, radix bupleuri 750g, Poria cocos 750g, peppermint 750g, Huang are attached
Piece 250g, Chinese cassia tree 250g, Fructus Corni 500g, bark of eucommia 500g, Semen Cuscutae 500g, cultivated land 750g, Chinese yam rhizome 500g, matrimony vine 750g,
The thick stick 350g of sika deer velvet antler two, spina date seed 750g, dried immature fruit of citron orange 500g, bighead atractylodes rhizome 750g, fructus gardeniae 500g.
The Chinese medicine composition is pill.
Embodiment 6
The present embodiment is the preparation method of embodiment 1, is comprised the following steps：
A, it is attached that 4 parts of ginseng, 4 parts of the Radix Astragali, 7 parts of RADIX ANGELICAE SINEINSIS, 6 parts of the root of herbaceous peony, 6 parts of radix bupleuri, 6 parts of Poria cocos, 6 parts of peppermint, Huang are chosen
2 parts of piece, 2 parts of Chinese cassia tree, 4 parts of Fructus Corni, 4 parts of the bark of eucommia, 4 parts of Semen Cuscutae, 6 parts of cultivated land, 4 parts of Chinese yam rhizome, 6 parts of matrimony vine, sika deer velvet antler
4 parts of two 2 parts of thick sticks, 6 parts of spina date seed and the dried immature fruit of citron orange, go the removal of impurity, shred, dry respectively, and are weighed according to the components by weight percent ratio of setting
It is standby afterwards；
B, it will be mixed well in step a according to the components by weight percent of setting than weighing rear standby bulk drug mixing, and add water
For the pure water of all 10 times of bulk drug weight summations, immersion is boiled by fire after 30 minutes, and then slow fire decocts 1 hour again, mistake
Filter, obtains the first filtrate and the first filter residue；
C, the first filter residue is added into the pure water that water is the first 5 times of filter residue weight summation again, it is big after soaking 30 minutes
Fire boils, and then slow fire decocts 0.5 hour again, filtering, obtains the second filtrate and the second filter residue, and by the second filtrate of gained with
First filtrate merges into the 3rd filtrate；
D, by the bighead atractylodes rhizome of 6 parts by weight and the fructus gardeniae stir-bake to yellowish of 4 parts by weight, the mountain Cape jasmine after the bighead atractylodes rhizome and stir-bake to yellowish after stir-bake to yellowish
After son is cooled to normal temperature, take out；
E, the bighead atractylodes rhizome after stir-bake to yellowish, the fructus gardeniae after stir-bake to yellowish and the second filter residue are mixed and mixed well, and add water as this three kinds
The pure water of 8 times of bulk drug weight summation soaks 30 minutes, and slow fire decocts 0.5 hour again after being boiled by fire, and filtering, obtains the 4th
Filtrate；
F, the 3rd filtrate and the 4th filtrate are mixed to get total filtrate.
G, total filtrate in step f is concentrated in the environment of 60 DEG C, vacuum 0.08Mpa as the dense of relative density 1.20
Contracting liquid.
Embodiment 7
The present embodiment is the preparation method of embodiment 1, is comprised the following steps：
A, it is attached that 6 parts of ginseng, 6 parts of the Radix Astragali, 8 parts of RADIX ANGELICAE SINEINSIS, 8 parts of the root of herbaceous peony, 8 parts of radix bupleuri, 8 parts of Poria cocos, 8 parts of peppermint, Huang are chosen
3 parts of piece, 3 parts of Chinese cassia tree, 6 parts of Fructus Corni, 6 parts of the bark of eucommia, 6 parts of Semen Cuscutae, 8 parts of cultivated land, 6 parts of Chinese yam rhizome, 8 parts of matrimony vine, sika deer velvet antler
6 parts of two 4 parts of thick sticks, 8 parts of spina date seed and the dried immature fruit of citron orange, go the removal of impurity, shred, dry respectively, and are weighed according to the components by weight percent ratio of setting
It is standby afterwards；
B, it will be mixed well in step a according to the components by weight percent of setting than weighing rear standby bulk drug mixing, and add water
For the pure water of all 12 times of bulk drug weight summations, immersion is boiled by fire after 30 minutes, and then slow fire decocts 2 hours again, mistake
Filter, obtains the first filtrate and the first filter residue；
C, the first filter residue is added into the pure water that water is the first 10 times of filter residue weight summation again, it is big after soaking 30 minutes
Fire boils, and then slow fire decocts 1.5 hours again, filtering, obtains the second filtrate and the second filter residue, and by the second filtrate of gained with
First filtrate merges into the 3rd filtrate；
D, by the bighead atractylodes rhizome of 8 parts by weight and the fructus gardeniae stir-bake to yellowish of 6 parts by weight, the mountain Cape jasmine after the bighead atractylodes rhizome and stir-bake to yellowish after stir-bake to yellowish
After son is cooled to normal temperature, take out；
E, the bighead atractylodes rhizome after stir-bake to yellowish, the fructus gardeniae after stir-bake to yellowish and the second filter residue are mixed and mixed well, and add water as this three kinds
The pure water of 10 times of bulk drug weight summation soaks 30 minutes, and slow fire decocts 1 hour again after being boiled by fire, and filtering, obtains the 4th
Filtrate；
F, the 3rd filtrate and the 4th filtrate are mixed to get total filtrate.
G, total filtrate in step f is concentrated in the environment of 60 DEG C, vacuum 0.08Mpa as the dense of relative density 1.30
Contracting liquid.
Embodiment 8
The present embodiment is the preparation method of embodiment 1, is comprised the following steps：
A, it is attached that 5 parts of ginseng, 5 parts of the Radix Astragali, 7 parts of RADIX ANGELICAE SINEINSIS, 7 parts of the root of herbaceous peony, 7 parts of radix bupleuri, 7 parts of Poria cocos, 7 parts of peppermint, Huang are chosen
2.5 parts of piece, 2.5 parts of Chinese cassia tree, 5 parts of Fructus Corni, 5 parts of the bark of eucommia, 5 parts of Semen Cuscutae, 7 parts of cultivated land, 5 parts of Chinese yam rhizome, 7 parts of matrimony vine, plum blossom
5 parts of 3 parts of two thick stick of pilose antler, 7 parts of spina date seed and the dried immature fruit of citron orange, go the removal of impurity, shred, dry respectively, and according to the components by weight percent ratio of setting
Weigh rear standby；
B, it will be mixed well in step a according to the components by weight percent of setting than weighing rear standby bulk drug mixing, and add water
For the pure water of all 11 times of bulk drug weight summations, immersion is boiled by fire after 30 minutes, and then slow fire decocts 1.5 hours again,
Filtering, obtains the first filtrate and the first filter residue；
C, the first filter residue is added into the pure water that water is the first 7 times of filter residue weight summation again, it is big after soaking 30 minutes
Fire boils, and then slow fire decocts 1 hour again, filtering, obtains the second filtrate and the second filter residue, and by the second filtrate of gained and the
One filtrate merges into the 3rd filtrate；
D, by the bighead atractylodes rhizome of 7 parts by weight and the fructus gardeniae stir-bake to yellowish of 5 parts by weight, the mountain Cape jasmine after the bighead atractylodes rhizome and stir-bake to yellowish after stir-bake to yellowish
After son is cooled to normal temperature, take out；
E, the bighead atractylodes rhizome after stir-bake to yellowish, the fructus gardeniae after stir-bake to yellowish and the second filter residue are mixed and mixed well, and add water as this three kinds
The pure water of 9 times of bulk drug weight summation soaks 30 minutes, and slow fire decocts 0.7 hour again after being boiled by fire, and filtering, obtains the 4th
Filtrate；
F, the 3rd filtrate and the 4th filtrate are mixed to get total filtrate.
G, total filtrate in step f is concentrated in the environment of 60 DEG C, vacuum 0.08Mpa as the dense of relative density 1.25
Contracting liquid.
Embodiment 9
The present embodiment be embodiment 3 preparation method, its on the basis of embodiment 6,
It is further comprising the steps of：
The concentrate in step g is taken, one or both of starch, dextrin or the lactose of 2 times of weight of concentrate is added, adopts
With thick paste granulation, pelletized, dried at 50 DEG C, whole grain, obtain granule.
In another embodiment, one or both of starch, dextrin or lactose of 5 times of weight of concentrate are added,
Dried at 70 DEG C.
In another embodiment, one or both of starch, dextrin or lactose of 3 times of weight of concentrate are added,
Dried at 60 DEG C.
Embodiment 10
The present embodiment be embodiment 3 preparation method, its on the basis of embodiment 6,
It is further comprising the steps of：
The concentrate in step g is taken, adds pure water dilution, and is bottled, then obtains oral liquid.
Embodiment 11
The present embodiment be embodiment 3 preparation method, its on the basis of embodiment 6,
It is further comprising the steps of：
The concentrate in step g is taken, one or both of starch, dextrin and the lactose of 2 times of weight of concentrate is added, adopts
With thick paste granulation, to be pelletized, dried at 50 DEG C, whole grain, obtain particle, quiet particulate abrasive is fitted into capsule into powder,
Both capsule is obtained.
In another embodiment, one or both of starch, dextrin and lactose of 5 times of weight of concentrate are added,
Dried at 70 DEG C.
In another embodiment, one or both of starch, dextrin and lactose of 3 times of weight of concentrate are added,
Dried at 60 DEG C.
Embodiment 12
The present embodiment be embodiment 3 preparation method, its on the basis of embodiment 6,
It is further comprising the steps of：
The concentrate in step g is taken, one or both of starch, dextrin and the lactose of 2 times of weight of concentrate is added, adopts
With thick paste granulation, pelletized, dried at 50 DEG C, whole grain, obtain particle；The magnesium stearate of particle weight 0.5% is added,
It is well mixed with particle, tabletting, both obtains tablet.
In another embodiment, one or both of starch, dextrin and lactose of 5 times of weight of concentrate are added,
Dried at 70 DEG C, add 1% magnesium stearate mixing.
In another embodiment, one or both of starch, dextrin and lactose of 3 times of weight of concentrate are added,
Dried at 60 DEG C, add 0.7% magnesium stearate mixing.
Clinical observation
Patients with hypertension 100, medical history 1~23 year.It is divided into two groups according to randomly assigne, if observation group's (Chinese medicine group) 50
Example, man 29, female 21；39~81 years old age, average age 55 years old.Control group (Western medicine group) 50, man 32, female 18；
37~83 years old age, average age 58 years old.Two groups of general information comparing differences are not statistically significant (P ＞ 0.05).
It is dialectical to patient's progress before observation group's medication, using prescription of the present invention, control group medicine：Nitrendipine, Kato are general
Profit, enteric coated aspirin and FUFANG LIXUEPING PIAN.1~2 time/d, blood pressure is monitored daily, to adjust medication alone or in combination, is used
1 year medicine time.
Blood pressure curative effect determinate standard refers to《New Chinese medicine guideline of clinical investigations (tentative)》Relevant criterion is formulated.It is aobvious
Effect：Heart function controls or improved more than 2 grades substantially；Effectively：Heart function improves I grade but not as good as II grade, invalid：Heart function carries
High unobvious relatively treat preceding aggravate；Total effective rate=obvious effective rate+effective percentage.
1 two groups of efficacy of antihypertensive treatment of table compare
| Group | It is effective | Effectively | It is invalid | Total effective rate |
| Observation group | 38 | 11 | 1 | 98% |
| Control group | 36 | 10 | 4 | 92% |
Blood pressure Comprehensive Control standard：
Cure：Blood pressure recovers to normal；It is effective：Diastole drops≤20mm Hg or decline reach critical hypertension；It is good
Turn：Diastole drops≤10mm Hg shrink drops≤20mm Hg；It is invalid：Blood pressure without be decreased obviously or diastole drops≤
5mm Hg shrink drops≤10mm Hg.
The pretherapy and post-treatment blood pressure determination value of table 2 compares
As can be seen here, the blood pressure situation before two groups of cases are intervened, after intervention, Chinese medicine group of the invention is better than Western medicine group, through t
Examine, difference is statistically significant (P ＜ 0.05).
Embodiment described above only expresses the embodiment of the present invention, and its description is more specific and detailed, but simultaneously
Therefore the limitation to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that for one of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect scope.
Claims (10)
1. a kind of Chinese medicine composition for treating hypertension, it is characterised in that including ginseng, the Radix Astragali, RADIX ANGELICAE SINEINSIS, the root of herbaceous peony, radix bupleuri, Fu
Siberian cocklebur, peppermint, yellow tag, Chinese cassia tree, Fructus Corni, the bark of eucommia, Semen Cuscutae, cultivated land, Chinese yam rhizome, matrimony vine, the thick stick of sika deer velvet antler two, spina date seed,
The dried immature fruit of citron orange, the bighead atractylodes rhizome and fructus gardeniae, wherein, the components by weight percent ratio of each composition is：
Ginseng 4-6 parts, Radix Astragali 4-6 parts, RADIX ANGELICAE SINEINSIS 7-8 parts, root of herbaceous peony 6-8 parts, radix bupleuri 6-8 parts, Poria cocos 6-8 parts, peppermint 6-8 parts,
Yellow tag 2-3 parts, Chinese cassia tree 2-3 parts, Fructus Corni 4-6 parts, bark of eucommia 4-6 parts, Semen Cuscutae 4-6 parts, cultivated land 6-8 parts, Chinese yam rhizome 4-6
Part, matrimony vine 6-8 parts, the thick stick 2-4 parts of sika deer velvet antler two, spina date seed 6-8 parts, dried immature fruit of citron orange 4-6 parts, bighead atractylodes rhizome 6-8 parts, fructus gardeniae 4-6 parts.
2. the Chinese medicine composition for the treatment of hypertension according to claim 1, it is characterised in that the components by weight percent ratio of each composition
For：
4 parts of ginseng, 4 parts of the Radix Astragali, 7 parts of RADIX ANGELICAE SINEINSIS, 6 parts of the root of herbaceous peony, 6 parts of radix bupleuri, 6 parts of Poria cocos, 6 parts of peppermint, 2 parts of yellow tag, Chinese cassia tree 2
Part, 4 parts of Fructus Corni, 4 parts of the bark of eucommia, 4 parts of Semen Cuscutae, 6 parts of cultivated land, 4 parts of Chinese yam rhizome, 6 parts of matrimony vine, 2 parts of two thick stick of sika deer velvet antler, wild jujube
6 parts of benevolence, 4 parts of the dried immature fruit of citron orange, 6 parts of the bighead atractylodes rhizome, 4 parts of fructus gardeniae.
3. the Chinese medicine composition for the treatment of hypertension according to claim 1, it is characterised in that the components by weight percent ratio of each composition
For：
5 parts of ginseng, 5 parts of the Radix Astragali, 7 parts of RADIX ANGELICAE SINEINSIS, 7 parts of the root of herbaceous peony, 7 parts of radix bupleuri, 7 parts of Poria cocos, 7 parts of peppermint, 2.5 parts of yellow tag, meat
2.5 parts of osmanthus, 5 parts of Fructus Corni, 5 parts of the bark of eucommia, 5 parts of Semen Cuscutae, 7 parts of cultivated land, 5 parts of Chinese yam rhizome, 7 parts of matrimony vine, the thick stick 3 of sika deer velvet antler two
Part, 7 parts of spina date seed, 5 parts of the dried immature fruit of citron orange, 7 parts of the bighead atractylodes rhizome, 5 parts of fructus gardeniae.
4. the Chinese medicine composition for the treatment of hypertension according to claim 1, it is characterised in that the components by weight percent ratio of each composition
For：
6 parts of ginseng, 6 parts of the Radix Astragali, 8 parts of RADIX ANGELICAE SINEINSIS, 8 parts of the root of herbaceous peony, 8 parts of radix bupleuri, 8 parts of Poria cocos, 8 parts of peppermint, 3 parts of yellow tag, Chinese cassia tree 3
Part, 6 parts of Fructus Corni, 6 parts of the bark of eucommia, 6 parts of Semen Cuscutae, 8 parts of cultivated land, 6 parts of Chinese yam rhizome, 8 parts of matrimony vine, 4 parts of two thick stick of sika deer velvet antler, wild jujube
8 parts of benevolence, 6 parts of the dried immature fruit of citron orange, 8 parts of the bighead atractylodes rhizome, 6 parts of fructus gardeniae.
5. the Chinese medicine composition of the treatment hypertension according to claim 1 or 2 or 3 or 4, it is characterised in that the Chinese medicine
Composition is scattered, tablet, pill, capsule, granule, honey pill agent or oral liquid.
6. a kind of preparation method of the Chinese medicine composition of the hypertension for the treatment of as claimed in claim 1, it is characterised in that including following
Step：
A, ginseng 4-6 parts, Radix Astragali 4-6 parts, RADIX ANGELICAE SINEINSIS 7-8 parts, root of herbaceous peony 6-8 parts, radix bupleuri 6-8 parts, Poria cocos 6-8 parts, peppermint are chosen
6-8 parts, yellow tag 2-3 parts, Chinese cassia tree 2-3 parts, Fructus Corni 4-6 parts, bark of eucommia 4-6 parts, Semen Cuscutae 4-6 parts, cultivated land 6-8 parts, Chinese yam
Medicine 4-6 parts, matrimony vine 6-8 parts, the thick stick 2-4 parts of sika deer velvet antler two, spina date seed 6-8 parts and dried immature fruit of citron orange 4-6 parts, the removal of impurity is gone respectively, shred,
Dry, and according to setting components by weight percent ratio weigh it is rear standby；
B, it will be mixed well in step a according to the components by weight percent of setting than weighing rear standby bulk drug mixing, and add water as institute
There is the pure water of 10-12 times of bulk drug weight summation, immersion is boiled by fire after 30 minutes, and then slow fire decocts 1-2 hours, mistake again
Filter, obtains the first filtrate and the first filter residue；
C, the first filter residue is added into the pure water that water is the first 5-10 times of filter residue weight summation, big fire after soaking 30 minutes again
Boil, then slow fire decocts 0.5-1.5 hours again, filtering, obtains the second filtrate and the second filter residue, and by the second filtrate of gained
The 3rd filtrate is merged into the first filtrate；
D, by the bighead atractylodes rhizome of 6-8 parts by weight and the fructus gardeniae stir-bake to yellowish of 4-6 parts by weight, the mountain Cape jasmine after the bighead atractylodes rhizome and stir-bake to yellowish after stir-bake to yellowish
After son is cooled to normal temperature, take out；
E, the bighead atractylodes rhizome after stir-bake to yellowish, the fructus gardeniae after stir-bake to yellowish and the second filter residue are mixed and mixed well, and it is three kinds of raw materials to add water
The pure water of 8-10 times of medicine weight summation soaks 30 minutes, and slow fire decocts 0.5-1 hours again after being boiled by fire, filtering, obtains the
Four filtrates；
F, the 3rd filtrate and the 4th filtrate are mixed to get total filtrate.
G, total filtrate in step f is concentrated in the environment of 60 DEG C, vacuum 0.08Mpa as relative density 1.20-1.30's
Concentrate.
7. the preparation method of the Chinese medicine composition of hypertension is treated according to claim 6, it is characterised in that also including following
Step：
The concentrate in step g is taken, one or both of the starch, dextrin or lactose of 2-5 times of weight of concentrate is added, uses
Thick paste granulation, is pelletized, and is dried at 50 DEG C -70 DEG C, whole grain, is obtained granule.
8. the preparation method of the Chinese medicine composition of hypertension is treated according to claim 6, it is characterised in that also including following
Step：
The concentrate in step g is taken, adds pure water dilution, and is bottled, then obtains oral liquid.
9. the preparation method of the Chinese medicine composition of hypertension is treated according to claim 6, it is characterised in that also including following
Step：
The concentrate in step g is taken, one or both of the starch, dextrin and lactose of 2-5 times of weight of concentrate is added, uses
Thick paste granulation, is pelletized, and is dried at 50 DEG C -70 DEG C, and whole grain obtains particle, and quiet particulate abrasive loads capsule into powder
In, both obtain capsule.
10. according to claim 6 treat hypertension Chinese medicine composition preparation method, it is characterised in that also include with
Lower step：
The concentrate in step g is taken, one or both of the starch, dextrin and lactose of 2-5 times of weight of concentrate is added, uses
Thick paste granulation, is pelletized, and is dried at 50 DEG C -70 DEG C, whole grain, is obtained particle；Add the hard of particle weight 0.5%-1%
Fatty acid magnesium, it is well mixed with particle, tabletting, both obtains tablet.
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Citations (2)
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|---|---|---|---|---|
| CN104666727A (en) * | 2013-11-29 | 2015-06-03 | 王玉青 | Formula of traditional Chinese medicine for treating hypertension |
| CN104984001A (en) * | 2015-06-05 | 2015-10-21 | 李跃 | Blood pressure reducing foot bath traditional Chinese medicine treating Yin and Yang deficiency type hypertension |
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2017
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666727A (en) * | 2013-11-29 | 2015-06-03 | 王玉青 | Formula of traditional Chinese medicine for treating hypertension |
| CN104984001A (en) * | 2015-06-05 | 2015-10-21 | 李跃 | Blood pressure reducing foot bath traditional Chinese medicine treating Yin and Yang deficiency type hypertension |
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Application publication date: 20171201 |