CN107412438B - Processing method of Chinese wolfberry compound traditional Chinese medicinal material - Google Patents
Processing method of Chinese wolfberry compound traditional Chinese medicinal material Download PDFInfo
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Abstract
The invention discloses a processing method of a Chinese wolfberry compound traditional Chinese medicinal material, which comprises the steps of screening by a large number of experiments, compacting Chinese wolfberry by adopting optimal high temperature and high pressure, heating and drying by adopting microwave, freezing by adopting ultralow temperature, then crushing by adopting ultramicro to obtain Chinese wolfberry medicinal powder with the particle size of 300 meshes, steaming the fresh land by using specific fructus amomi, yellow wine and cassia bark at high temperature and high pressure, then drying by adopting a microwave heating mode, freezing by adopting ultralow temperature, and then crushing by adopting ultramicro to obtain prepared rehmannia root medicinal powder with the particle size of 300 meshes; the invention adopts high temperature and high pressure to prepare ginseng through a large number of experiments, and adopts microwave heating drying of killing and enzyme-protecting glycosides, thereby improving the content of the total ginsenoside of the blood activating component and improving the clinical curative effect. The whole processing method has the advantages of strong operability, high processing efficiency, stable and unified process, high dissolution rate of the active ingredients of the prepared medlar, prepared rehmannia root and ginseng medicinal materials, quick absorption by human bodies, capability of obviously improving the immunity of the human bodies and important application prospect.
Description
Technical Field
The invention relates to a processing method of traditional Chinese medicine decoction pieces, in particular to a processing method of a Chinese wolfberry compound traditional Chinese medicine, belonging to the technical field of traditional Chinese medicine pharmacy.
Background
Lycium chinense is a kind of plant belonging to Solanaceae, Lycium, Solanales, such as Lycium chinense fruit, whose tender leaves are called Lycium chinense head, and its medicinal species is Ningxia Lycium chinense. The medlar has more effects, has the effects of reducing blood sugar, resisting fatty liver, resisting atherosclerosis, protecting liver, improving human immunity and the like, wherein medlar polysaccharide in medlar is a main active ingredient, and because medlar has high sugar content and is relatively high in viscosity after being dried, the medlar can not be pulverized by a pulverizer, so that the prior art cannot realize superfine pulverization of medlar.
Radix rehmanniae and radix rehmanniae Preparata are both derived from dried root of rehmannia glutinosa Libosch of Scrophulariaceae, and are different processed products of the same medicine. The radix rehmanniae is dried product of fresh product; the radix rehmanniae Preparata is steamed product of radix rehmanniae. Both of them can nourish yin and promote fluid production, so they are indicated for yin deficiency and fluid deficiency. Sheng Di Huang is good at cooling blood, Sheng Di Huang is bitter and cold in property and clearing heat, and sweet and cold in nature and moistening yin, so it is a cool and moistening product good at nourishing yin, clearing heat and cooling blood. Has the effects of clearing heat and cooling blood, nourishing yin and promoting the production of body fluid and moistening intestines. Prepared rehmannia root, radix rehmanniae Praeparata is good at replenishing blood, is sweet in taste, slightly warm and moist, enters liver and kidney meridians, is good at replenishing blood and nourishing yin, and can supplement essence and benefit marrow, and is mainly used for treating all the symptoms of blood deficiency, yin deficiency and oligospermia. At present, the method for processing the rehmannia glutinosa by the rehmannia glutinosa needs to be boiled and dried in the sun for a plurality of times, for example, the 'nine-steaming nine-sieving' process is complex, the time is long, the operation standards are different, and the error is larger. And the prepared rehmannia root is soft after being processed by the rehmannia root, and the powder grinding processing cannot be realized by the prior art.
Ginseng is sweet in taste and slightly bitter in nature. It enters spleen, lung and heart meridians. Has effects in invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting salivation, quenching thirst, tranquilizing mind, and improving intelligence. Can be used for treating cold limbs, weak pulse, spleen deficiency, anorexia, lung deficiency, cough, asthma, body fluid deficiency, thirst, palpitation, amnesia, sexual impotence, cold womb, heart failure, and cardiogenic shock due to qi deficiency. In order to increase the tonifying effect of ginseng, the invention adopts a honey processing method to process.
Disclosure of Invention
The purpose of the invention is as follows: the invention aims to overcome the defects of the prior art and provide a processing method which is reasonable in process design, strong in operability, adopts microwave drying and heating and has very high working efficiency. The invention can process medlar, radix rehmanniae and ginseng, in particular can carry out superfine grinding on medlar with high sugar content and high viscosity and soft radix rehmanniae preparata, and carry out honey processing on ginseng, thereby promoting the dissolution of the effective components of the medlar and the radix rehmanniae preparata and increasing the tonifying effect of the ginseng.
The technical scheme is as follows: in order to achieve the above purpose, the invention adopts the technical scheme that:
a processing method of a Chinese wolfberry compound traditional Chinese medicinal material is characterized by comprising the following steps:
(1) processing of Chinese wolfberry
(1.1) putting a fresh wolfberry fruit into a bamboo-woven dustpan, cleaning, filtering, drying in the sun until the moisture is reduced to 20-30%, then putting in a cool and ventilated place, and drying in the shade;
(1.2) feeding the Chinese wolfberry obtained in the step (1.1) into a microwave heating instrument, carrying out microwave heating treatment for 5-10 minutes, and taking out to obtain dried Chinese wolfberry;
(1.3) taking the dried medlar obtained in the step (1.2), adding refined honey which is 0.2-0.5 times of the weight of the medlar, uniformly mixing, then placing in a microwave heating instrument, and carrying out microwave heating treatment for 3-6 minutes;
(1.4) placing the honey-processed medlar obtained in the step (1.3) at minus 60-70 ℃, and preserving for 6-12 hours in a freezing way;
(1.5) pulverizing the frozen medlar obtained in the step (1.4) by using an ultrafine pulverizer, and sieving by using a 300-mesh sieve to obtain medlar powder processed with honey;
(2) processing of dried rehmannia root medicinal material
(2.1) taking the rehmannia root medicinal materials, cleaning, adding the fructus amomi, the yellow wine and the cassia bark, putting the mixture into a pressure cooker, steaming the mixture for 4 to 12 hours at high pressure and high temperature, taking out the mixture, conveying the mixture into a microwave instrument, heating and drying the mixture for 10 to 30 minutes, and taking out the mixture; continuously adding fructus amomi, yellow wine and cassia bark, and repeating the steaming and microwave heating drying treatment for 2-3 times to obtain prepared rehmannia root;
(2.2) placing the prepared rehmannia root processed in the step (2.1) at minus 50-70 ℃, and preserving for 6-12 hours in a freezing way;
(2.3) pulverizing the prepared rehmannia root frozen in the step (2.2) by using an ultrafine pulverizer, and sieving by using a 300-mesh sieve to obtain prepared rehmannia root powder;
(3) processing of honey-processed ginseng
(3.1) taking a raw ginseng, cleaning, putting the raw ginseng into a pressure cooker, steaming the raw ginseng for 30 to 60 minutes at high pressure and high temperature, taking out the raw ginseng, putting the raw ginseng into ice water, soaking the raw ginseng for 15 to 30 minutes, taking out the raw ginseng, pricking small holes in the directions parallel to and perpendicular to the ginseng by using a needle, soaking the raw ginseng into refined honey, steaming the raw ginseng for 10 to 30 minutes at high temperature and high pressure, taking out the raw ginseng, sending the raw ginseng into a microwave instrument, heating and drying the raw ginseng for 10 to 30 minutes; repeating the steps for 2 to 3 times;
(3.2) pulverizing the honey-processed ginseng prepared in the step (3.1) by using an ultrafine pulverizer, and sieving by using a 300-mesh sieve to obtain honey-processed ginseng powder;
(4) and (3) mixing the medlar powder processed with honey in the step (1.5), the rehmannia glutinosa powder in the step (2) and the ginseng powder processed with honey in the step (3) in proportion.
As a preferred scheme, the processing method of the Chinese wolfberry compound traditional Chinese medicinal material comprises the following steps:
(1) processing of Chinese wolfberry
(1.1) putting a fresh wolfberry fruit into a bamboo-woven dustpan, cleaning, filtering, drying in the sun until the moisture is reduced to 20-30%, then putting in a cool and ventilated place, and drying in the shade;
(1.2) feeding the Chinese wolfberry obtained in the step (1.1) into a microwave heating instrument, carrying out microwave heating treatment for 5-10 minutes, and taking out to obtain dried Chinese wolfberry;
(1.3) taking the dried medlar obtained in the step (1.2), adding refined honey which is 0.5 times of the weight of the medlar, uniformly mixing, then placing in a microwave heating instrument, and carrying out microwave heating treatment for 5 minutes;
(1.4) placing the honey-processed medlar obtained in the step (1.3) at-70 ℃, and preserving for 12 hours in a freezing way;
(1.5) pulverizing the frozen medlar obtained in the step (1.4) by using an ultrafine pulverizer, and sieving by using a 300-mesh sieve to obtain medlar powder processed with honey;
(2) processing of dried rehmannia root medicinal material
(2.1) taking the rehmannia root medicinal materials, cleaning, adding the fructus amomi, the yellow wine and the cassia bark, putting the mixture into a pressure cooker, steaming the mixture for 8 to 12 hours at high pressure and high temperature, taking out the mixture, conveying the mixture into a microwave instrument, heating and drying the mixture for 20 minutes, and taking out the mixture; continuously adding fructus Amomi, yellow wine and cortex Cinnamomi Japonici, repeating above steaming and microwave heating and drying for 3 times to obtain radix rehmanniae Preparata;
(2.2) placing the prepared rehmannia root processed in the step (2.1) at minus 60 ℃, and preserving for 12 hours in a freezing way;
(2.3) pulverizing the prepared rehmannia root frozen in the step (2.2) by using an ultrafine pulverizer, and sieving by using a 300-mesh sieve to obtain prepared rehmannia root powder;
(3) processing of honey-processed ginseng
(3.1) taking a raw ginseng, cleaning, putting the raw ginseng into a pressure cooker, steaming the raw ginseng for 30 minutes at high pressure and high temperature, taking out the raw ginseng, putting the raw ginseng into ice water, soaking the raw ginseng for 30 minutes, taking out the raw ginseng, pricking pores in the directions parallel to and perpendicular to the raw ginseng by using a needle, soaking the raw ginseng into refined honey, steaming the raw ginseng for 30 minutes at high temperature and high pressure, taking out the raw ginseng, sending the raw ginseng into a microwave instrument, heating and drying the raw ginseng for 10 minutes; repeating the steps for 3 times;
(3.2) pulverizing the honey-processed ginseng prepared in the step (3.1) by using an ultrafine pulverizer, and sieving by using a 300-mesh sieve to obtain honey-processed ginseng powder;
(4) and (3) mixing the medlar powder processed with honey in the step (1.5), the rehmannia glutinosa powder in the step (2) and the ginseng powder processed with honey in the step (3) according to the mass ratio of 1-3: 2-6: 1-2.
According to the preferable scheme, in the processing method of the Chinese wolfberry compound traditional Chinese medicinal material, in the step (2), the mass ratio of the radix rehmanniae, the fructus amomi, the yellow wine and the cassia bark is 5-10: 1-4: 10-20: 2-6.
As a particularly effective scheme, in the step (2), the mass ratio of the radix rehmanniae, the fructus amomi, the yellow wine and the cassia bark is 5:1:10: 2.
As a preferred scheme, the processing method of the Chinese wolfberry compound traditional Chinese medicinal material adopts a honey processing method to process Chinese wolfberry, so that the tonifying effect is improved, and the immunity of a human body is improved. Particularly, according to the invention, according to the conditions that the wolfberry contains high polysaccharide content, superfine grinding cannot be realized, and the wolfberry easily sticks to a cutter head, the wolfberry polysaccharide and other components can be hardened by placing the wolfberry polysaccharide and other components at minus 70 ℃ after microwave drying through a large number of experiments, then the 300-mesh superfine grinding is realized, the technical problem that the wolfberry polysaccharide and other components cannot be ground in the prior art can be overcome, and the dissolution and absorption of the wolfberry polysaccharide and other active components can be greatly realized after the superfine grinding is realized. And honey is solidified under microwave and is adhered to the surface of the medlar, compared with the prior art that the honey is easy to dissolve and flow in a drying mode, the drying effect is better, and the technical effect is very good. And the content of the polysaccharide in the medlar is measured by adopting a sulfuric acid phenol colorimetric method under 485nm (a standard curve A is 0.0318X-0.0032, and r is 0.999), and the percentage content of the polysaccharide in the medlar is 14.9 percent after being processed by the method.
The invention realizes a new processing technology for radix rehmanniae, the radix rehmanniae preparata is a processed product of the radix rehmanniae, but the clinical effects of the radix rehmanniae preparata and the processed product of the radix rehmanniae are obviously different, the invention selects fructus amomi, yellow wine and cassia bark as processing auxiliary materials through a large amount of experimental screening, the fructus amomi, the yellow wine and the cassia bark are cooked under the optimized pressure of 1.5 to 2Mpa and are heated and dried by a microwave instrument, the conversion of iridoid effective components can be accelerated, the processing from the radix rehmanniae to the radix rehmanniae preparata is promoted, and the processing quality of the radix rehmanniae preparata is improved. Compared with the prior art of 'steaming and drying in the sun' in the nine times, the processing efficiency is high, and the iridoid components (including catalpol, digitoxin A, B, C and D) of the prepared rehmannia root are detected by high performance liquid chromatography, and the content of the iridoid components (including catalpol, digitoxin A, B, C and D) of the prepared rehmannia root is 5-8% higher than that of the prepared rehmannia root by the prior art (yellow wine is steamed repeatedly for 5 times); compared with a sulfuric acid phenol colorimetric method, glucose is used as a reference substance, the sulfuric acid phenol colorimetric method is adopted to measure the content of the polysaccharide in the prepared rehmannia root in a colorimetric manner under 485nm (a standard curve A is 0.0318X-0.0032, and r is 0.999), and a detection result shows that the content of the prepared rehmannia root polysaccharide obtained by processing the prepared rehmannia root is improved by 7-9% compared with the content of the polysaccharide obtained by processing the prepared rehmannia root by the processing method in the prior art (yellow wine is steamed repeatedly for 5 times); and the ninhydrin colorimetric method is adopted for detection, so that the content of amino acid in the prepared rehmannia root can be improved by 3-5% compared with the prior processing method (repeated steaming for 5 times by yellow wine). The processing method can greatly improve the content of effective components, improve the quality of medicinal materials and improve the clinical effect, and after the rehmannia glutinosa is obtained by processing the rehmannia glutinosa, the properties become flexible, the content of polysaccharide ammonia is higher, and the conventional powdering and wall breaking treatment cannot be realized.
The invention screens the processing process of ginseng through a large number of experimental screens, adopts a specific high-temperature high-pressure steaming process to kill enzyme and preserve glycoside and improve the content of ginsenoside, adopts honey refining high-temperature high-pressure steaming to process the ginseng at high temperature and high pressure, can greatly improve the permeation of refined honey into ginseng medicinal materials and improve the tonifying effect of the ginseng, adopts a microwave heating and drying mode to improve the heating and drying effect and improve the drying speed, and honey is solidified under microwave and adheres to the surface of the ginseng and permeates into the ginseng, compared with the prior art, the drying mode is easy to dissolve honey and drip honey, has better drying effect and obtains very good technical effect.
Preferably, the processing method of the compound Chinese medicinal material of medlar comprises the steps of (3.1) taking a ginseng raw product, cleaning, placing the ginseng raw product in a pressure cooker, steaming for 30 to 60 minutes under the pressure of 1.5 to 2Mpa, taking out, placing the ginseng raw product in ice water, soaking for 15 to 30 minutes, taking out, pricking pores in the ginseng raw product along the direction parallel to and perpendicular to the ginseng raw product with a needle, soaking in refined honey, placing the refined honey in the pressure cooker, steaming for 10 to 30 minutes under the pressure of 2Mpa and high temperature and high pressure, taking out, sending the obtained product into a microwave instrument, heating and drying for 10 to 30 minutes, and taking out; repeating the above steps for 3 times. The invention adopts the optimized processing technology of the ginseng processed with honey, and the active ingredient of the processed ginseng, namely the total ginsenoside, can reach 4.7 percent. And the percentage contents of the ginsenoside Rg3 and Rh2 can be respectively improved by 0.5-0.7 percent and 0.7-1.5 percent compared with the common sun-dried ginseng.
As a preferred scheme, the processing method of the Chinese wolfberry compound traditional Chinese medicinal material comprises the steps of (2.1) taking a rehmannia root medicinal material, cleaning, adding fructus amomi, yellow wine and cassia bark, putting into a pressure cooker, cooking for 4-12 hours under the pressure of 1.5-2 Mpa, taking out, sending into a microwave instrument, heating and drying for 10-30 minutes, and taking out; and (3) continuously adding fructus amomi, yellow wine and cassia bark, and repeating the steaming and microwave heating drying treatment for 2-3 times to obtain the prepared rehmannia root.
Preferably, in the processing method of the compound Chinese wolfberry medicinal material, in the step (4), the Chinese wolfberry medicinal powder processed with honey, the rehmannia glutinosa medicinal powder and the ginseng medicinal powder processed with honey are mixed according to the mass ratio of 3:4:1, and the mixture is filled into capsules and then compressed into tablets or prepared into buccal tablets and other dosage forms. The invention obtains the best mass ratio according to a large amount of experimental screening, and can greatly improve the immunity of the human body.
According to the preferable scheme, in the processing method of the Chinese wolfberry compound traditional Chinese medicinal materials, the microwave power of a microwave heating instrument is 5 KW. In the prior art, heating drying modes such as sun drying and drying are adopted, so that the condition requirement is high, the drying time is long, the external environment influence is large, several days are needed, the efficiency is low, and Chinese medicinal materials are easy to rot in the drying process. The microwave heating drying method is adopted, so that the enzymes in the medicinal materials can be killed, the enzymolysis of the effective components is prevented, the water in the medicinal materials can be quickly dried, the microorganisms can be killed, the storage period and the quality guarantee period of the medicinal materials are prolonged, the drying speed is high, the working efficiency is very high, and compared with the prior art, the microwave heating drying method has a very good technical effect.
Has the advantages that: compared with the prior art, the processing method of the Chinese wolfberry compound traditional Chinese medicine provided by the invention has the following advantages:
according to the invention, a large number of experimental screens are carried out, the medlar is prepared by adopting optimal high-temperature high-pressure honey, microwave heating and drying are adopted, particularly ultra-low temperature freezing is adopted, and then superfine grinding is adopted to obtain the medlar powder with the particle size of 300 meshes, so that the content of effective components such as medlar polysaccharide and the like can be greatly improved, the processing technology is stable, and the processing efficiency is high.
According to the invention, through a large number of experimental screens, the specific fructus amomi, yellow wine and cassia bark are used for steaming the radix rehmanniae at high temperature and high pressure, then the radix rehmanniae is dried by adopting a microwave heating mode, and is frozen at ultra-low temperature, and then the radix rehmanniae preparata powder with the particle size of 300 meshes is obtained by adopting superfine grinding, so that the contents of active ingredients such as iridoid, polysaccharide, amino acid and the like in the radix rehmanniae preparata can be greatly improved, the processing technology is stable, and the processing efficiency is high.
The invention adopts high-temperature and high-pressure honey to prepare the ginseng through a large number of experiments, and adopts microwave heating and drying of the enzyme-killing and glycoside-protecting to improve the content of the total ginsenoside of the blood-activating component and improve the clinical curative effect.
The whole processing method has the advantages of strong operability, high processing efficiency, stable and unified process, high dissolution rate of the active ingredients of the prepared medlar, prepared rehmannia root and ginseng medicinal materials, quick absorption by human bodies, capability of obviously improving the immunity of the human bodies and important application prospect.
Detailed Description
The invention will be better understood from the following examples. However, those skilled in the art will readily appreciate that the specific material ratios, process conditions and results thereof described in the examples are illustrative only and should not be taken as limiting the invention as detailed in the claims.
Example 1
1. A processing method of a Chinese wolfberry compound traditional Chinese medicinal material comprises the following steps:
(1) processing of Chinese wolfberry
(1.1) putting a fresh wolfberry fruit into a bamboo-woven dustpan, cleaning, filtering, drying in the sun until the moisture is reduced to 20-30%, then putting in a cool and ventilated place, and drying in the shade;
(1.2) putting the medlar obtained in the step (1.1) into a microwave heating instrument, carrying out microwave heating treatment for 8 minutes, and taking out to obtain dried medlar;
(1.3) taking the dried medlar obtained in the step (1.2), adding refined honey which is 0.5 times of the weight of the medlar, uniformly mixing, then placing in a microwave heating instrument, and carrying out microwave heating treatment for 5 minutes;
(1.4) placing the honey-processed medlar obtained in the step (1.3) at-70 ℃, and preserving for 12 hours in a freezing way;
(1.5) pulverizing the frozen medlar obtained in the step (1.4) by using an ultrafine pulverizer, and sieving by using a 300-mesh sieve to obtain medlar powder processed with honey;
(2) processing of dried rehmannia root medicinal material
(2.1) cleaning the dried rehmannia root, adding fructus amomi, yellow wine and cassia bark in a weight ratio of 5:1:10:2, putting the mixture into a pressure cooker, cooking the mixture for 8 hours under 1.5Mpa, taking the mixture out, putting the mixture into a microwave instrument, heating and drying the mixture for 20 minutes, and taking the mixture out; continuously adding fructus Amomi, yellow wine and cortex Cinnamomi Japonici, repeating above steaming and microwave heating and drying for 3 times to obtain radix rehmanniae Preparata;
(2.2) placing the prepared rehmannia root processed in the step (2.1) at minus 60 ℃, and preserving for 12 hours in a freezing way;
(2.3) pulverizing the prepared rehmannia root frozen in the step (2.2) by using an ultrafine pulverizer, and sieving by using a 300-mesh sieve to obtain prepared rehmannia root powder;
(3) processing of honey-processed ginseng
(3.1) taking a raw ginseng, cleaning, placing the raw ginseng in a pressure cooker, steaming for 30 minutes at a high pressure and a high temperature of 1.5MPa, taking out, placing the raw ginseng in ice water for soaking for 30 minutes, taking out, pricking small holes in the ginseng along the directions parallel to and perpendicular to the ginseng, immersing the raw ginseng in refined honey, steaming for 30 minutes at a high temperature and a high pressure of 2MPa, taking out, sending the raw ginseng into a microwave instrument for heating and drying for 10 minutes, and taking out; repeating the steps for 3 times;
(3.2) pulverizing the honey-processed ginseng prepared in the step (3.1) by using an ultrafine pulverizer, and sieving by using a 300-mesh sieve to obtain honey-processed ginseng powder;
(4) and (3) mixing the medlar powder processed with honey in the step (1.5), the rehmannia glutinosa powder in the step (2) and the ginseng powder processed with honey in the step (3) according to the mass ratio of 3:4: 1.
2. Determination of content
2.1 the content of the polysaccharide in the medlar is measured by colorimetry under 485nm by adopting a sulphuric acid phenol colorimetry (a standard curve A is 0.0318X-0.0032, r is 0.999), and the percentage content of the polysaccharide in the medlar is 14.9 percent after being processed by the method.
2.2 the total iridoid content is 5.78% measured by ethanol colorimetry with hydrochloric acid-dinitrophenyl hydrazine at 463nm (catalpol is used as a reference substance, and the standard curve A is 7.492+0.0616, and r is 0.998).
2.3 measuring vanillin-glacial acetic acid and perchloric acid at 552nm (standard curve A is 0.0586-0.0156, r is 0.999) to obtain processed Ginseng radix active component with total ginsenoside content of 4.79%.
The processing method provided by the invention can obviously improve the content of lycium barbarum polysaccharide, prepared rehmannia root iridoid and total ginsenoside in ginseng, and can obviously improve the absorption rate by adopting ultramicro powdering.
Example 2
1. A processing method of a Chinese wolfberry compound traditional Chinese medicinal material comprises the following steps:
(1) processing of Chinese wolfberry
(1.1) putting a fresh wolfberry fruit into a bamboo-woven dustpan, cleaning, filtering, drying in the sun until the moisture is reduced to 20-30%, then putting in a cool and ventilated place, and drying in the shade;
(1.2) putting the medlar obtained in the step (1.1) into a microwave heating instrument, carrying out microwave heating treatment for 10 minutes, and taking out to obtain dried medlar;
(1.3) taking the dried medlar obtained in the step (1.2), adding refined honey which is 0.3 times of the weight of the medlar, uniformly mixing, then placing in a microwave heating instrument, and carrying out microwave heating treatment for 5 minutes;
(1.4) placing the honey-processed medlar obtained in the step (1.3) at minus 60 ℃, and preserving for 10 hours in a freezing way;
(1.5) pulverizing the frozen medlar obtained in the step (1.4) by using an ultrafine pulverizer, and sieving by using a 300-mesh sieve to obtain medlar powder processed with honey;
(2) processing of dried rehmannia root medicinal material
(2.1) cleaning the dried rehmannia root, adding fructus amomi, yellow wine and cassia bark in a weight ratio of 6: 2: 20: 4, putting the mixture into a pressure cooker, cooking the mixture for 12 hours under 2Mpa, taking the mixture out, putting the mixture into a microwave instrument, heating and drying the mixture for 15 minutes, and taking the mixture out; continuously adding fructus Amomi, yellow wine and cortex Cinnamomi Japonici, repeating above steaming and microwave heating and drying for 3 times to obtain radix rehmanniae Preparata;
(2.2) placing the prepared rehmannia root processed in the step (2.1) at minus 70 ℃, and preserving for 6 hours in a freezing way;
(2.3) pulverizing the prepared rehmannia root frozen in the step (2.2) by using an ultrafine pulverizer, and sieving by using a 300-mesh sieve to obtain prepared rehmannia root powder;
(3) processing of honey-processed ginseng
(3.1) taking a raw ginseng, cleaning, placing the raw ginseng in a pressure cooker, steaming for 10 minutes at high pressure and high temperature under 2MPa, taking out, placing the raw ginseng in ice water for 20 minutes, taking out, pricking small holes in the ginseng along the parallel and vertical directions by using needles, immersing the raw ginseng in refined honey, steaming for 20 minutes at high temperature and high pressure under 2MPa, taking out, sending the raw ginseng into a microwave instrument for heating and drying for 10 minutes, and taking out; repeating the steps for 3 times;
(3.2) pulverizing the honey-processed ginseng prepared in the step (3.1) by using an ultrafine pulverizer, and sieving by using a 300-mesh sieve to obtain honey-processed ginseng powder;
(4) and (3) mixing the medlar powder processed with honey in the step (1.5), the rehmannia glutinosa powder in the step (2) and the ginseng powder processed with honey in the step (3) according to the mass ratio of 1:4: 1.
2. Determination of content
2.1 the content of the polysaccharide in the medlar is measured by colorimetry under 485nm by adopting a sulphuric acid phenol colorimetry (a standard curve A is 0.0318X-0.0032, and r is 0.999), and the percentage content of the polysaccharide in the medlar is 14.2 percent after being processed by the method.
2.2 the total iridoid content is 5.51% measured by ethanol colorimetry with hydrochloric acid-dinitrophenyl hydrazine at 463nm (catalpol is used as a reference substance, and the standard curve A is 7.492+0.0616, and r is 0.998).
2.3 measuring vanillin-glacial acetic acid and perchloric acid at 552nm (standard curve A is 0.0586-0.0156, r is 0.999) to obtain processed Ginseng radix active component with total ginsenoside content of 4.70%.
The processing method provided by the invention can obviously improve the content of lycium barbarum polysaccharide, prepared rehmannia root iridoid and total ginsenoside in ginseng, and can obviously improve the absorption rate by adopting ultramicro powdering.
Example 3 experiment on immunomodulating Effect
1. Experimental Material
1.1 Experimental animals
40 ICR mice, half male and half female, with a weight of 18-22g, were offered by Nanjing university of traditional Chinese medicine (SPF grade). The animals are raised in SPF mouse laboratory of animal center of Nanjing university of traditional Chinese medicine at 23 + -2 deg.C and humidity of 55 + -5%, and fed with granulated feed and freely drinking water.
1.2 drugs and reagents
The Chinese wolfberry compound traditional Chinese medicine powder prepared in the embodiment 1 and the embodiment 2; sheep red blood cells (available from Guangzhou pistit Biotech Co., Ltd.); guinea pig serum (supplied by Guangzhou pistit Biotech, Inc.); the kit is provided by Nanjing institute of bioengineering; other reagents are all domestic analytical purifiers.
1.3 Experimental instruments
A freeze dryer (laboco corporation, usa), an ultraviolet spectrophotometer (leberty instruments ltd, beijing), a microplate reader (PerkinElmer ltd), a full-automatic hemocyte analyzer (hessenck, japan), and an electronic balance (sydow scientific instruments ltd).
2. Experimental methods
2.1 modeling and administration of immuno-compromised mice
40 mice, each half of male and female, are weighed and numbered, are randomly divided into 4 groups, and are provided with a blank group and a model group, and the medlar compound traditional Chinese medicine powder prepared in the embodiment 1 and the embodiment 2. And 3d, performing intragastric administration of 0.4mL of CMC-Na solution and 0.4mL of intraperitoneal injection of normal saline every day in the blank group, and performing intragastric administration of 0.4mL of CMC-Na solution and 50mg/kg of intraperitoneal injection of Cyclophosphamide (CTX) in the model group every day. Each group was administered 2 times a day (10mg/kg) for 5 days, and the model group was administered for 3 days. The Chinese wolfberry compound traditional Chinese medicine group is respectively administrated by intragastric administration every day, and simultaneously, 50mg/kg of CTX is injected into the abdominal cavity.
2.2 determination of macrophage phagocytic function
After 30min of the last administration, 0.05mL/10g India ink diluted 3 times was injected via the tail vein of the mice by carbon particle clearance. 20 μ L of blood was collected from the retro-orbital at 30s and 360s, respectively, and added to 0.1% Na2CO3The solution was shaken up in 2mL and the optical density values were measured in a spectrophotometer at 680nm wavelength, OD1 for 30s and OD2 for 360 s. And calculating the clearance index K according to a formula, and obtaining the phagocytosis index alpha after the K value is converted by the weight and the weight of the liver and the spleen.
Clearance index K ═ l gOD1-l gOD2)/(t2-t1)
Phagocytosis index α ═ body weight/liver and spleen weight × 3K
Experimental data on
Showing that the comparison among groups adopts t test and P<0.05 is statistically significant.
3. Results of the experiment
3.1 Effect on phagocytic function of mononuclear macrophages in immunocompromised mice
The experimental results in table 1 show that the phagocytic index and the phagocytic coefficient of the model group mice are significantly reduced compared with the blank group (P < 0.01); compared with the model group, the Chinese wolfberry compound traditional Chinese medicine powder prepared in the example 1 and the example 2 has obviously increased phagocytosis index and phagocytosis coefficient (P < 0.01). The result shows that the medicinal powder prepared by the processing method can obviously increase the phagocytic function of mononuclear macrophages of mice with low immunity.
TABLE 1 Effect of groups on phagocytic function of monocyte macrophages in hypoimmunity mice
Note: in comparison with the blank set, the results,##P<0.01, comparing with the model group,*P<0.05，**P<0.01。
the experimental results show that the Chinese wolfberry compound traditional Chinese medicine powder provided by the invention can obviously improve the phagocytic function of macrophages of mice and can improve the immunity.
The above embodiments are merely illustrative of the technical concept and features of the present invention, and the present invention is not limited thereto, and equivalent changes and modifications made according to the spirit of the present invention should be covered thereby.
Claims (5)
1. A processing method of a Chinese wolfberry compound traditional Chinese medicinal material is characterized by comprising the following steps:
(1) processing of Chinese wolfberry
(1.1) putting a fresh wolfberry fruit into a bamboo-woven dustpan, cleaning, filtering, drying in the sun until the moisture is reduced to 20-30%, then putting in a cool and ventilated place, and drying in the shade;
(1.2) feeding the Chinese wolfberry obtained in the step (1.1) into a microwave heating instrument, carrying out microwave heating treatment for 5-10 minutes, and taking out to obtain dried Chinese wolfberry;
(1.3) taking the dried medlar obtained in the step (1.2), adding refined honey which is 0.2-0.5 times of the weight of the medlar, uniformly mixing, then placing in a microwave heating instrument, and carrying out microwave heating treatment for 3-6 minutes;
(1.4) placing the honey-processed medlar obtained in the step (1.3) at minus 60-70 ℃, and preserving for 6-12 hours in a freezing way;
(1.5) pulverizing the frozen medlar obtained in the step (1.4) by using an ultrafine pulverizer, and sieving by using a 300-mesh sieve to obtain medlar powder processed with honey;
(2) processing of dried rehmannia root medicinal material
(2.1) cleaning the dried rehmannia root medicinal materials, adding the dried rehmannia root, the fructus amomi, the yellow wine and the cassia bark in a mass ratio of 5-10: 1-4: 10-20: 2-6, putting the mixture into a pressure cooker, steaming the mixture for 4-12 hours at high pressure and high temperature, taking out the mixture, feeding the mixture into a microwave instrument, heating and drying the mixture for 10-30 minutes, and taking out the mixture; continuously adding fructus amomi, yellow wine and cassia bark, and repeating the steaming and microwave heating drying treatment for 2-3 times to obtain prepared rehmannia root;
(2.2) taking the prepared rehmannia root processed in the step (2.1), placing at minus 50-70 ℃, and preserving for 6-12 hours in a freezing way;
(2.3) pulverizing the prepared rehmannia root frozen in the step (2.2) by using an ultrafine pulverizer, and sieving by using a 300-mesh sieve to obtain prepared rehmannia root powder;
(3) processing of honey-processed ginseng
(3.1) taking a raw ginseng, cleaning, putting the raw ginseng into a pressure cooker, steaming the raw ginseng for 30 to 60 minutes at high pressure and high temperature, taking out the raw ginseng, putting the raw ginseng into ice water, soaking the raw ginseng for 15 to 30 minutes, taking out the raw ginseng, pricking small holes in the directions parallel to and perpendicular to the ginseng by using a needle, soaking the raw ginseng into refined honey, steaming the raw ginseng for 10 to 30 minutes at high temperature and high pressure, taking out the raw ginseng, sending the raw ginseng into a microwave instrument, heating and drying the raw ginseng for 10 to 30 minutes; repeating the steps for 2 to 3 times;
(3.2) pulverizing the honey-processed ginseng prepared in the step (3.1) by using an ultrafine pulverizer, and sieving by using a 300-mesh sieve to obtain honey-processed ginseng powder;
(4) mixing the medlar powder processed with honey in the step (1.5), the rehmannia glutinosa powder in the step (2) and the ginseng powder processed with honey in the step (3) according to a proportion;
the microwave power of the microwave heating apparatus is 5 KW.
2. The processing method of the compound Chinese herbal medicine of the Chinese wolfberry as claimed in claim 1, characterized by comprising the following steps:
(1) processing of Chinese wolfberry
(1.1) putting a fresh wolfberry fruit into a bamboo-woven dustpan, cleaning, filtering, drying in the sun until the moisture is reduced to 20-30%, then putting in a cool and ventilated place, and drying in the shade;
(1.2) feeding the Chinese wolfberry obtained in the step (1.1) into a microwave heating instrument, carrying out microwave heating treatment for 5-10 minutes, and taking out to obtain dried Chinese wolfberry;
(1.3) taking the dried medlar obtained in the step (1.2), adding refined honey which is 0.5 times of the weight of the medlar, uniformly mixing, then placing in a microwave heating instrument, and carrying out microwave heating treatment for 5 minutes;
(1.4) placing the honey-processed medlar obtained in the step (1.3) at-70 ℃, and preserving for 12 hours in a freezing way;
(1.5) pulverizing the frozen medlar obtained in the step (1.4) by using an ultrafine pulverizer, and sieving by using a 300-mesh sieve to obtain medlar powder processed with honey;
(2) processing of dried rehmannia root medicinal material
(2.1) cleaning the rehmannia root medicinal materials, adding the rehmannia root, the fructus amomi, the yellow wine and the cassia bark in a mass ratio of 5-10: 1-4: 10-20: 2-6, putting the mixture into a pressure cooker, steaming the mixture for 8-12 hours at high pressure and high temperature, taking out the mixture, feeding the mixture into a microwave instrument, heating and drying the mixture for 20 minutes, and taking out the mixture; continuously adding fructus Amomi, yellow wine and cortex Cinnamomi Japonici, repeating above steaming and microwave heating and drying for 3 times to obtain radix rehmanniae Preparata;
(2.2) taking the prepared rehmannia root processed in the step (2.1), placing at minus 60 ℃, and preserving for 12 hours in a freezing way;
(2.3) pulverizing the prepared rehmannia root frozen in the step (2.2) by using an ultrafine pulverizer, and sieving by using a 300-mesh sieve to obtain prepared rehmannia root powder;
(3) processing of honey-processed ginseng
(3.1) taking a raw ginseng, cleaning, putting the raw ginseng into a pressure cooker, steaming the raw ginseng for 30 minutes at high pressure and high temperature, taking out the raw ginseng, putting the raw ginseng into ice water, soaking the raw ginseng for 30 minutes, taking out the raw ginseng, pricking pores in the directions parallel to and perpendicular to the raw ginseng by using a needle, soaking the raw ginseng into refined honey, steaming the raw ginseng for 30 minutes at high temperature and high pressure, taking out the raw ginseng, sending the raw ginseng into a microwave instrument, heating and drying the raw ginseng for 10 minutes; repeating the steps for 3 times;
(3.2) pulverizing the honey-processed ginseng prepared in the step (3.1) by using an ultrafine pulverizer, and sieving by using a 300-mesh sieve to obtain honey-processed ginseng powder;
(4) and (3) mixing the medlar powder processed with honey in the step (1.5), the rehmannia glutinosa powder in the step (2) and the ginseng powder processed with honey in the step (3) according to the mass ratio of 1-3: 2-6: 1-2.
3. The processing method of the compound Chinese medicinal material of medlar according to claim 1 or 2, wherein in the step (4), the medlar powder processed with honey, the rehmannia glutinosa powder and the ginseng powder processed with honey are mixed according to the mass ratio of 3:4:1, and the mixture is filled into capsules to be prepared into capsules, and is tableted to be prepared into tablets or is prepared into buccal tablets.
4. The processing method of the compound Chinese herbal medicine of medlar according to claim 1, wherein the step (2.1) is to take the dried rehmannia root, clean the dried rehmannia root, add the amomum fruit, the yellow wine and the cassia bark, place the mixture into a pressure cooker, steam the mixture for 4 to 12 hours under the pressure of 1.5 to 2Mpa, take out the mixture, send the mixture into a microwave instrument, heat and dry the mixture for 10 to 30 minutes, and take out the mixture; and (3) continuously adding fructus amomi, yellow wine and cassia bark, and repeating the steaming and microwave heating drying treatment for 2-3 times to obtain the prepared rehmannia root.
5. The processing method of the compound Chinese herbal medicine of the medlar according to claim 4, wherein the step (3.1) is to take the ginseng raw product, clean the ginseng raw product, put the ginseng raw product in a pressure cooker, steam the ginseng raw product for 30 to 60 minutes under the pressure of 1.5 to 2MPa, take the ginseng raw product out, put the ginseng raw product in ice water, soak the ginseng raw product for 15 to 30 minutes, take the ginseng raw product out, use a needle to pierce a small hole along the direction parallel to and perpendicular to the ginseng raw product, soak the ginseng raw product in refined honey, put the ginseng raw product in the pressure cooker, steam the ginseng raw product for 10 to 30 minutes under the pressure of 2MPa for 10 to 30 minutes at high temperature and high pressure; repeating the above steps for 3 times.
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