CN107406422B - 作为sGC刺激剂的吡唑衍生物 - Google Patents

作为sGC刺激剂的吡唑衍生物 Download PDF

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CN107406422B
CN107406422B CN201580062199.3A CN201580062199A CN107406422B CN 107406422 B CN107406422 B CN 107406422B CN 201580062199 A CN201580062199 A CN 201580062199A CN 107406422 B CN107406422 B CN 107406422B
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compound
disease
solution
vacuo
water
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CN107406422A (zh
Inventor
T·C·巴登
J·E·舍贝克
G·R·雷尼
P·A·任豪沃
N·佩尔
T·中井
A·莫尔梅里安
T·W-H·李
J·荣格
J·贾
K·伊艾
R·R·艾扬格
G-尹·杰米·艾姆
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Ironwood Pharmaceuticals Inc
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Ironwood Pharmaceuticals Inc
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580062199.3A 2014-09-17 2015-09-16 作为sGC刺激剂的吡唑衍生物 Expired - Fee Related CN107406422B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462051557P 2014-09-17 2014-09-17
US62/051,557 2014-09-17
US201562204710P 2015-08-13 2015-08-13
US62/204,710 2015-08-13
PCT/US2015/050468 WO2016044447A1 (en) 2014-09-17 2015-09-16 Pyrazole derivatives as sgc stimulators

Publications (2)

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CN107406422A CN107406422A (zh) 2017-11-28
CN107406422B true CN107406422B (zh) 2022-02-01

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US (4) US20170291889A1 (cg-RX-API-DMAC7.html)
EP (1) EP3194382B1 (cg-RX-API-DMAC7.html)
JP (1) JP6624616B2 (cg-RX-API-DMAC7.html)
CN (1) CN107406422B (cg-RX-API-DMAC7.html)
AU (2) AU2015317824A1 (cg-RX-API-DMAC7.html)
CA (1) CA2959757A1 (cg-RX-API-DMAC7.html)
MX (1) MX2017003516A (cg-RX-API-DMAC7.html)
WO (1) WO2016044447A1 (cg-RX-API-DMAC7.html)

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CN105859726B (zh) * 2016-05-18 2018-07-13 南京富润凯德生物医药有限公司 一种嘧啶并环中选择性脱卤素的方法
EA201990237A1 (ru) * 2016-07-07 2019-08-30 Сайклерион Терапьютикс, Инк. Новые способы получения стимуляторов растворимой гуанилатциклазы
IL263996B2 (en) * 2016-07-07 2024-03-01 Ironwood Pharmaceuticals Inc Solid forms of an sgc stimulator
MX382762B (es) * 2016-07-07 2025-03-13 Cyclerion Therapeutics Inc Procesos novedosos para preparacion de estimuladores de guanilato ciclasa soluble.
CN110022871A (zh) 2016-10-11 2019-07-16 拜耳制药股份公司 包含sGC刺激物和盐皮质激素受体拮抗剂的组合产品
EP3525778A1 (de) 2016-10-11 2019-08-21 Bayer Pharma Aktiengesellschaft Kombination enthaltend sgc aktivatoren und mineralocorticoid-rezeptor-antagonisten
EP3554488A2 (en) 2016-12-13 2019-10-23 Cyclerion Therapeutics, Inc. Use of sgc stimulators for the treatment of esophageal motility disorders
WO2019081456A1 (en) 2017-10-24 2019-05-02 Bayer Aktiengesellschaft USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT
EP3498298A1 (en) 2017-12-15 2019-06-19 Bayer AG The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi)
CN111712247B (zh) * 2017-12-19 2024-02-09 塞科里昂医疗股份有限公司 sGC刺激剂
WO2019161534A1 (en) * 2018-02-22 2019-08-29 Ironwood Pharmaceuticals, Inc. Novel processes and intermediates for preparation of soluble guanylate cyclase stimulators
KR20250048609A (ko) 2018-01-10 2025-04-09 사이클리온 테라퓨틱스, 인크. 가용성 구아닐레이트 시클라제 자극제의 제조를 위한 신규 방법 및 중간체
WO2019211081A1 (en) 2018-04-30 2019-11-07 Bayer Aktiengesellschaft The use of sgc activators and sgc stimulators for the treatment of cognitive impairment
JP2021523201A (ja) 2018-05-15 2021-09-02 バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 神経線維感作に関連する疾患を治療するための１，３−チアゾール−２−イル置換ベンズアミド
US11508483B2 (en) 2018-05-30 2022-11-22 Adverio Pharma Gmbh Method of identifying a subgroup of patients suffering from dcSSc which benefits from a treatment with sGC stimulators and sGC activators in a higher degree than a control group
EP3820476A1 (en) 2018-07-11 2021-05-19 Cyclerion Therapeutics, Inc. Use of sgc stimulators for the treatment of mitochonrial disorders
EP3911675A1 (en) 2019-01-17 2021-11-24 Bayer Aktiengesellschaft Methods to determine whether a subject is suitable of being treated with an agonist of soluble guanylyl cyclase (sgc)
CN110498740A (zh) * 2019-09-18 2019-11-26 重庆医药高等专科学校 一种生产3-羟基丙酸的方法
CN110577467A (zh) * 2019-09-18 2019-12-17 重庆医药高等专科学校 一种3-羟基丙酸的合成方法
US20230330066A1 (en) * 2019-12-18 2023-10-19 Bioradical Research Institute Corp. Vasodilator and Use Thereof
CN112007027B (zh) * 2020-09-14 2022-07-15 长春金赛药业有限责任公司 含酯基芳香丙酰胺类化合物及其代谢产物在制备治疗心衰药物中的应用
CN112169717B (zh) * 2020-09-30 2022-06-03 深圳大学 一种微胶囊化氯化血红素及其制备方法与应用
US20230372317A1 (en) * 2020-10-27 2023-11-23 Pts Consulting, Llc A liquid injectable composition of donepezil
WO2023009710A1 (en) * 2021-07-28 2023-02-02 Cyclerion Therapeutics, Inc. Treatment of hfpef in post-menopausal women with an sgc stimulator
WO2025106494A1 (en) * 2023-11-15 2025-05-22 Yanping Kong Compositions and methods for treating erectile dysfunction and male hypogonadism
WO2025189097A1 (en) * 2024-03-07 2025-09-12 Yale University Artificial intelligence-guided screening of under-recognized cardiomyopathies adapted for point-of-care cardiac ultrasound
DE202024103267U1 (de) 2024-06-18 2024-07-09 Ashutosh Aggarwal Ein System zur Herstellung einer antihypertensiven Formulierung mit verlängerter Freisetzung
CN119185590B (zh) * 2024-11-28 2025-02-25 华润双鹤利民药业（济南）有限公司 羟丙基-β-环糊精在制备维立西呱固体制剂中的应用、固体制剂及制备方法
CN119909007B (zh) * 2025-04-02 2025-06-03 四川大学 一种具有氧化还原活性和电活性的可注射水凝胶及其制备方法与应用

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