CN107397786A - 一种连钱草鲜榨喷雾干燥粉末饮片的制备工艺 - Google Patents
一种连钱草鲜榨喷雾干燥粉末饮片的制备工艺 Download PDFInfo
- Publication number
- CN107397786A CN107397786A CN201710739126.4A CN201710739126A CN107397786A CN 107397786 A CN107397786 A CN 107397786A CN 201710739126 A CN201710739126 A CN 201710739126A CN 107397786 A CN107397786 A CN 107397786A
- Authority
- CN
- China
- Prior art keywords
- ground ivy
- longtube ground
- ivy herb
- materical crude
- crude slice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000014043 Glechoma hederacea var parviflora Nutrition 0.000 title claims abstract description 31
- 244000215554 Nepeta hederacea Species 0.000 title claims abstract description 31
- 239000003814 drug Substances 0.000 title claims abstract description 21
- 238000005516 engineering process Methods 0.000 title claims abstract description 8
- 239000000843 powder Substances 0.000 title claims abstract description 8
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 239000000463 material Substances 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 238000003756 stirring Methods 0.000 claims abstract description 9
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 8
- 239000012141 concentrate Substances 0.000 claims description 4
- 238000009461 vacuum packaging Methods 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 238000001694 spray drying Methods 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000003306 harvesting Methods 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000002386 leaching Methods 0.000 abstract 1
- 230000000192 social effect Effects 0.000 abstract 1
- 238000000605 extraction Methods 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 206010007027 Calculus urinary Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 208000001786 gonorrhea Diseases 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 208000008281 urolithiasis Diseases 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公布了一种连钱草鲜榨喷雾干燥粉末饮片的制备工艺。该工艺在连钱草药材采收后，净选、淋洗，并趁鲜压榨，滤取药汁。药渣再加水搅拌，过滤压榨。所得药汁合并后减压浓缩，喷雾干燥，收集喷干产物，经粉碎后真空包装。此法制备的连钱草粉末饮片，最大限度地保留了药材中的极性和非极性有效成分。饮片利于储运，方便调剂，质量可控，疗效可靠，对保障中医药临床疗效具有重要的意义。本法的推广实施，将有显著的社会意义和经济效益。
Description
技术领域
本发明属于中药材加工领域，尤其涉及中药连钱草饮片的加工工艺。
背景技术
中药连钱草为唇形科植物活血丹Glechoma longituba (Nakai) Kupr.的干燥地上部分。本品具有利湿通淋，清热解毒，散瘀消肿的功效，用于热淋、石淋、湿热黄疸、疮痈肿痛、跌打损伤等的治疗。
常见的连钱草饮片的加工方式为：春至秋季采收，除去杂质，晒干，再打包储运。此类草药饮片，体积庞大，卫生学指标差，容易污染和霉变，质量很难保证，不利于配方调剂和确保其临床疗效，甚至给患者带来隐性的危害。
目前，市场上也有连钱草药材经过提取后制成的颗粒饮片销售。颗粒饮片的制备过程，提取不仅耗时耗能，而且因常用大量的水做溶媒，药材中的非极性有效成分很难被提取出来。此外，由于提取用的连钱草药材也是干燥并经过长时间储藏的，因此，有效成分的损失也是很大的。为了确保连钱草药材的临床有效、质量稳定，一种新型的连钱草饮片亟待开发。
发明内容
本发明公布了 “一种连钱草鲜榨喷雾干燥粉末饮片的制备工艺”。本工艺可以最大限度的同时保留连钱草药材中的极性和非极性有效成分，避免药材在现有的饮片加工和储运过程中引起的有效成分的丢失和药材品质的下降，减少药材受霉菌等的污染，对确保连钱草饮片的质量稳定和临床安全有效具有重要的意义。
为了实现上述目的，本发明的技术方案为：
在连钱草采收期采集其全草，洗净，切成1~2cm的段，加入药材重量0.5~1倍量的水，搅拌15~30分钟，趁鲜压榨，收集初榨药汁，药渣加入1~5倍量的水，搅拌5~30min，压榨取汁，所剩药渣再加入1~5倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100~200目筛过滤，得连钱草药汁。将得到的连钱草药汁于40~75℃条件下减压浓缩至相对密度为1.02~1.15的浓缩液，并将此浓缩液喷雾干燥，进风口温度设定为90~140℃，出风口温度为80~110℃，收集干燥产物，粉碎后过60~100目筛，真空包装即可。
在产品包装袋的标签上，印刷上品名、药用部位、种植地、饮片生产商、生产日期、主要成分含量、性味归经、功能主治、用法用量、毒副作用及禁忌证等信息。袋内附上连钱草的薄层鉴别图谱和/或高效液相特征图谱，作为产品的“身份证”。此外，在产品的包装袋上，印有二维码，通过扫描可以链接获取产品的原植物照片、药材照片、饮片照片、性状及显微鉴别特征等信息。
本发明的有益之处在于：
新鲜采集的连钱草药材，净选洗涤后直接压榨、过滤、减压浓缩、喷雾干燥，所得到的粉末饮片，可以最大限度地保留药材中的有效成分。 这种饮片体积较之于传统饮片体积大大地减小，真空包装，使得饮片质量更加稳定，利于储运和临床调剂，具有十分显著的社会意义和经济意义。
具体实施方式
实施例1
将新鲜采集的连钱草药材，洗净，切成1cm的段，加入药材重量0.5倍量的水，搅拌15分钟，趁鲜压榨，收集初榨药汁，药渣加入5倍量的水，搅拌5min，压榨取汁，所剩药渣再加入5倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁， 200目筛过滤，得连钱草药汁。将得到的连钱草药汁减压浓缩，温度设定为65℃。在浓缩所得浸膏相对密度为1.05时，喷雾干燥，进风口温度为140℃，出风口温度为100℃，收集喷干物，低温粉碎，过80目筛，水分含量不高于12%，装袋，1kg/袋，加入袋装抗氧剂和干燥剂，真空封装，贴签即可。
实施例2
将新鲜采集的连钱草药材，洗净，切成2cm的段，加入药材重量1倍量的水，搅拌30分钟，趁鲜压榨，收集初榨药汁，药渣加入5倍量的水，搅拌5min，压榨取汁，所剩药渣再加入3倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100目筛过滤，得连钱草药汁。将得到的连钱草药汁减压浓缩，温度设定为70℃。在浓缩所得浸膏相对密度为1.07时，喷雾干燥，进风口温度为120℃，出风口温度为90℃，收集喷干物，低温粉碎，过60目筛，水分含量不高于12%，装袋，1kg/袋，加入袋装抗氧剂和干燥剂，真空封装，贴签即可。
以上实施例，仅为说明本项发明的技术思想，不能凭此限定本发明的保护范围 凡是按照本发明提出的技术思想，在技术方案基础上所做的任何改动，均落入本发明保护的范围之内。
Claims (2)
1.一种连钱草鲜榨喷雾干燥粉末饮片的制备工艺，其特征在于：在连钱草采收期采集其全草，洗净，切成1~2cm的段，加入药材重量0.5~1倍量的水，搅拌15~30分钟，趁鲜压榨，收集初榨药汁，药渣加入1~5倍量的水，搅拌5~30min，压榨取汁，所剩药渣再加入1~5倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100~200目筛过滤，得连钱草药汁。
2.根据权利要求1所述的一种连钱草鲜榨喷雾干燥粉末饮片的制备工艺，其特征在于：将得到的连钱草药汁于40~75℃条件下减压浓缩至相对密度为1.02~1.15的浓缩液，并将此浓缩液喷雾干燥，进风口温度设定为90~140℃，出风口温度为80~110℃，收集干燥产物，粉碎后过60~100目筛，真空包装即可。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739126.4A CN107397786A (zh) | 2017-08-25 | 2017-08-25 | 一种连钱草鲜榨喷雾干燥粉末饮片的制备工艺 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739126.4A CN107397786A (zh) | 2017-08-25 | 2017-08-25 | 一种连钱草鲜榨喷雾干燥粉末饮片的制备工艺 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107397786A true CN107397786A (zh) | 2017-11-28 |
Family
ID=60396601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710739126.4A Pending CN107397786A (zh) | 2017-08-25 | 2017-08-25 | 一种连钱草鲜榨喷雾干燥粉末饮片的制备工艺 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107397786A (zh) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213553A (zh) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | 一种白花蛇舌草鲜榨喷雾干燥粉末饮片及其制备工艺 |
| CN105213460A (zh) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | 一种仙人掌鲜榨喷雾干燥粉末饮片及其制备工艺 |
| CN105213444A (zh) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | 一种马齿苋鲜榨喷雾干燥粉末饮片及其制备工艺 |
| CN105213551A (zh) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | 一种白花蛇舌草鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN105213660A (zh) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | 一种芦荟鲜榨喷雾干燥颗粒饮片及其制备工艺 |
-
2017
- 2017-08-25 CN CN201710739126.4A patent/CN107397786A/zh active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213553A (zh) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | 一种白花蛇舌草鲜榨喷雾干燥粉末饮片及其制备工艺 |
| CN105213460A (zh) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | 一种仙人掌鲜榨喷雾干燥粉末饮片及其制备工艺 |
| CN105213444A (zh) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | 一种马齿苋鲜榨喷雾干燥粉末饮片及其制备工艺 |
| CN105213551A (zh) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | 一种白花蛇舌草鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN105213660A (zh) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | 一种芦荟鲜榨喷雾干燥颗粒饮片及其制备工艺 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107432883A (zh) | 一种透骨草鲜榨真空干燥粉末饮片的制备工艺 | |
| CN107362182A (zh) | 一种凤尾草鲜榨真空干燥粉末饮片的制备工艺 | |
| CN107468751A (zh) | 一种连钱草鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107441223A (zh) | 一种鱼腥草鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107714754A (zh) | 一种绞股蓝鲜榨冷冻干燥粉末饮片的制备工艺 | |
| CN107441131A (zh) | 一种金钱草鲜榨喷雾干燥粉末饮片的制备工艺 | |
| CN107375364A (zh) | 一种金钱草鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107397786A (zh) | 一种连钱草鲜榨喷雾干燥粉末饮片的制备工艺 | |
| CN107485633A (zh) | 一种艾叶鲜榨喷雾干燥粉末饮片的制备工艺 | |
| CN107362180A (zh) | 一种伸筋草鲜榨喷雾干燥粉末饮片的制备工艺 | |
| CN107375401A (zh) | 一种绞股蓝鲜榨冷冻干燥粉末饮片的制备工艺 | |
| CN107334814A (zh) | 一种连钱草鲜榨真空干燥粉末饮片的制备工艺 | |
| CN106109724A (zh) | 一种马鞭草鲜榨喷雾干燥粉末饮片及其制备工艺 | |
| CN107485642A (zh) | 一种半枝莲鲜榨真空干燥粉末饮片的制备工艺 | |
| CN107441132A (zh) | 一种老鹳草鲜榨喷雾干燥粉末饮片的制备工艺 | |
| CN107485640A (zh) | 一种泽兰鲜榨喷雾干燥粉末饮片的制备工艺 | |
| CN107375363A (zh) | 一种金钱草鲜榨真空干燥粉末饮片的制备工艺 | |
| CN107334797A (zh) | 一种凌霄花鲜榨喷雾干燥粉末饮片的制备工艺 | |
| CN107412414A (zh) | 一种鱼腥草鲜榨喷雾干燥粉末饮片的制备工艺 | |
| CN107441155A (zh) | 一种连钱草鲜榨冷冻干燥粉末饮片的制备工艺 | |
| CN107441149A (zh) | 一种地锦草鲜榨真空干燥粉末饮片的制备工艺 | |
| CN107362197A (zh) | 一种泽兰鲜榨真空干燥粉末饮片的制备工艺 | |
| CN107485653A (zh) | 一种翻白草鲜榨真空干燥粉末饮片的制备工艺 | |
| CN107714753A (zh) | 一种绞股蓝鲜榨真空干燥粉末饮片的制备工艺 | |
| CN107375463A (zh) | 一种枇杷叶鲜榨喷雾干燥粉末饮片的制备工艺 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171128 |
|
| WD01 | Invention patent application deemed withdrawn after publication |