CN107485653A - 一种翻白草鲜榨真空干燥粉末饮片的制备工艺 - Google Patents

一种翻白草鲜榨真空干燥粉末饮片的制备工艺 Download PDF

Info

Publication number
CN107485653A
CN107485653A CN201710739117.5A CN201710739117A CN107485653A CN 107485653 A CN107485653 A CN 107485653A CN 201710739117 A CN201710739117 A CN 201710739117A CN 107485653 A CN107485653 A CN 107485653A
Authority
CN
China
Prior art keywords
potentilla discolor
concoction
squeezing
vacuum drying
fresh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710739117.5A
Other languages
English (en)
Inventor
徐自升
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201710739117.5A priority Critical patent/CN107485653A/zh
Publication of CN107485653A publication Critical patent/CN107485653A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本发明公布了一种翻白草鲜榨真空干燥粉末饮片的制备工艺。该工艺在翻白草药材采收后，净选、淋洗、切段，并趁鲜压榨，滤取药汁。药渣再加水搅拌，过滤压榨。所得药汁合并后减压浓缩，真空干燥，粉碎后真空包装。此法制备的翻白草粉末饮片，最大限度地保留了药材中的极性和非极性有效成分。饮片利于储运，方便调剂，质量可控，疗效可靠，对保障中医药临床疗效具有重要的意义。本法的推广实施，将有显著的社会意义和经济效益。

Description

一种翻白草鲜榨真空干燥粉末饮片的制备工艺
技术领域
本发明属于中药材加工领域，尤其涉及中药翻白草饮片的加工工艺。
背景技术
中药翻白草为蔷薇科委陵菜属植物翻白草Potentilla discolor Bge.的干燥全草或地上部分。本品清热解毒，凉血止血，可用来治疗痢疾、腹泻、白带、疟疾、便血、赤痢腹痛、痔疮出血等症。
常见的翻白草饮片的加工方式为：夏、秋二季采收，除去杂质，晒干，再打包储运。此类草药饮片，体积庞大，卫生学指标差，容易污染和霉变，质量很难保证，不利于配方调剂和确保其临床疗效，甚至给患者带来隐性的危害。
目前，市场上也有翻白草药材经过提取后制成的颗粒饮片销售。颗粒饮片的制备过程，提取不仅耗时耗能，而且因常用大量的水做溶媒，药材中的非极性有效成分很难被提取出来。此外，由于提取用的翻白草药材也是干燥并经过长时间储藏的，因此，有效成分的损失也是很大的。为了确保翻白草药材的临床有效、质量稳定，一种新型的翻白草饮片亟待开发。
发明内容
本发明公布了 “一种翻白草鲜榨真空干燥粉末饮片的制备工艺”。本工艺可以最大限度的同时保留翻白草药材中的极性和非极性有效成分，避免药材在现有的饮片加工和储运过程中引起的有效成分的丢失和药材品质的下降，减少药材受霉菌等的污染，对确保翻白草饮片的质量稳定和临床安全有效具有重要的意义。
为了实现上述目的，本发明的技术方案为：
在翻白草采收期采集其全草，洗净，切成1~2cm的段，加入药材重量0.5~1倍量的水，搅拌15~30分钟，趁鲜压榨，收集初榨药汁，药渣加入1~5倍量的水，搅拌5~30min，压榨取汁，所剩药渣再加入1~5倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100~200目筛过滤，得翻白草药汁。将得到的翻白草药汁于40~75℃条件下减压浓缩至相对密度为1.05~1.30的浸膏，并将其于40~70℃真空干燥4~8小时后粉碎过60~120目筛，真空包装，即得翻白草鲜榨真空干燥粉末饮片。
在产品包装袋的标签上，印刷上品名、药用部位、种植地、饮片生产商、生产日期、主要成分含量、性味归经、功能主治、用法用量、毒副作用及禁忌证等信息。袋内附上翻白草的薄层鉴别图谱和/或高效液相特征图谱，作为产品的“身份证”。此外，在产品的包装袋上，印有二维码，通过扫描可以链接获取产品的原植物照片、药材照片、饮片照片、性状及显微鉴别特征等信息。
本发明的有益之处在于：
新鲜采集的翻白草药材，净选洗涤后直接压榨、过滤、减压浓缩、真空干燥，所得到的粉末饮片，可以最大限度地保留药材中的有效成分。 这种饮片体积较之于传统饮片体积大大地减小，真空包装，使得饮片质量更加稳定，利于储运和临床调剂，具有十分显著的社会意义和经济意义。
具体实施方式
实施例1
将新鲜采集的翻白草药材，洗净，切成1cm的段，加入药材重量0.5倍量的水，搅拌15分钟，趁鲜压榨，收集初榨药汁，药渣加入5倍量的水，搅拌5min，压榨取汁，所剩药渣再加入3倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100目筛过滤，得翻白草药汁。将翻白草药汁减压浓缩，温度设定为65℃。在浓缩所得浸膏相对密度为1.15时，转移到真空干燥箱内，于60℃干燥8小时，粉碎后过60目筛，装袋，1kg/袋，加入袋装抗氧化剂和干燥剂，真空封装即可。
实施例2
将新鲜采集的翻白草药材，洗净，切成2cm的段，加入药材重量1倍量的水，搅拌30分钟，趁鲜压榨，收集初榨药汁，药渣加入3倍量的水，搅拌10min，压榨取汁，所剩药渣再加入3倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，200目筛过滤，得翻白草药汁。将翻白草药汁减压浓缩，温度设定为70℃。在浓缩所得浸膏相对密度为1.10时，转移到真空干燥箱内，于65℃干燥6小时，粉碎后过60目筛，装袋，1kg/袋，加入袋装抗氧化剂和干燥剂，真空封装即可。
以上实施例，仅为说明本项发明的技术思想，不能凭此限定本发明的保护范围 凡是按照本发明提出的技术思想，在技术方案基础上所做的任何改动，均落入本发明保护的范围之内。

Claims (2)

1.一种翻白草鲜榨真空干燥粉末饮片的制备工艺，其特征在于：在翻白草采收期采集其全草，洗净，切成1~2cm的段，加入药材重量0.5~1倍量的水，搅拌15~30分钟，趁鲜压榨，收集初榨药汁，药渣加入1~5倍量的水，搅拌5~30min，压榨取汁，所剩药渣再加入1~5倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100~200目筛过滤，得翻白草药汁。
2.根据权利要求1所述的一种翻白草鲜榨真空干燥粉末饮片的制备工艺，其特征在于：将得到的翻白草药汁于40~75℃条件下减压浓缩至相对密度为1.05~1.30的浸膏，并将其于40~70℃真空干燥4~8小时后粉碎过60~120目筛，真空包装，即得翻白草鲜榨真空干燥粉末饮片。
CN201710739117.5A 2017-08-25 2017-08-25 一种翻白草鲜榨真空干燥粉末饮片的制备工艺 Pending CN107485653A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710739117.5A CN107485653A (zh) 2017-08-25 2017-08-25 一种翻白草鲜榨真空干燥粉末饮片的制备工艺

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710739117.5A CN107485653A (zh) 2017-08-25 2017-08-25 一种翻白草鲜榨真空干燥粉末饮片的制备工艺

Publications (1)

Publication Number Publication Date
CN107485653A true CN107485653A (zh) 2017-12-19

Family

ID=60650799

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710739117.5A Pending CN107485653A (zh) 2017-08-25 2017-08-25 一种翻白草鲜榨真空干燥粉末饮片的制备工艺

Country Status (1)

Country Link
CN (1) CN107485653A (zh)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105998133A (zh) * 2016-07-23 2016-10-12 徐漫 一种半边莲鲜榨真空干燥粉末饮片及其制备工艺
CN106109544A (zh) * 2016-07-24 2016-11-16 徐漫 一种地锦草鲜榨真空干燥粉末饮片及其制备工艺
CN106109596A (zh) * 2016-07-23 2016-11-16 徐自升 一种车前草鲜榨真空干燥粉末饮片及其制备工艺
CN106109723A (zh) * 2016-07-23 2016-11-16 徐漫 一种马鞭草鲜榨真空干燥粉末饮片及其制备工艺

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105998133A (zh) * 2016-07-23 2016-10-12 徐漫 一种半边莲鲜榨真空干燥粉末饮片及其制备工艺
CN106109596A (zh) * 2016-07-23 2016-11-16 徐自升 一种车前草鲜榨真空干燥粉末饮片及其制备工艺
CN106109723A (zh) * 2016-07-23 2016-11-16 徐漫 一种马鞭草鲜榨真空干燥粉末饮片及其制备工艺
CN106109544A (zh) * 2016-07-24 2016-11-16 徐漫 一种地锦草鲜榨真空干燥粉末饮片及其制备工艺

Similar Documents

Publication Publication Date Title
CN107432883A (zh) 一种透骨草鲜榨真空干燥粉末饮片的制备工艺
CN107582624A (zh) 一种广藿香鲜榨真空干燥粉末饮片的制备工艺
CN107362182A (zh) 一种凤尾草鲜榨真空干燥粉末饮片的制备工艺
CN107441223A (zh) 一种鱼腥草鲜榨喷雾干燥颗粒饮片的制备工艺
CN107441131A (zh) 一种金钱草鲜榨喷雾干燥粉末饮片的制备工艺
CN107485653A (zh) 一种翻白草鲜榨真空干燥粉末饮片的制备工艺
CN107375364A (zh) 一种金钱草鲜榨喷雾干燥颗粒饮片的制备工艺
CN107375394A (zh) 一种瞿麦鲜榨冷冻干燥粉末饮片的制备工艺
CN107441149A (zh) 一种地锦草鲜榨真空干燥粉末饮片的制备工艺
CN107397769A (zh) 一种老鹳草鲜榨真空干燥粉末饮片的制备工艺
CN107375363A (zh) 一种金钱草鲜榨真空干燥粉末饮片的制备工艺
CN107375511A (zh) 一种鱼腥草鲜榨真空干燥粉末饮片的制备工艺
CN107441132A (zh) 一种老鹳草鲜榨喷雾干燥粉末饮片的制备工艺
CN107334814A (zh) 一种连钱草鲜榨真空干燥粉末饮片的制备工艺
CN107441202A (zh) 一种枇杷叶鲜榨真空干燥粉末饮片的制备工艺
CN107485642A (zh) 一种半枝莲鲜榨真空干燥粉末饮片的制备工艺
CN107362188A (zh) 一种大青叶鲜榨真空干燥粉末饮片的制备工艺
CN107412414A (zh) 一种鱼腥草鲜榨喷雾干燥粉末饮片的制备工艺
CN107412290A (zh) 一种凌霄花鲜榨真空干燥粉末饮片的制备工艺
CN107432884A (zh) 一种鸡骨草鲜榨真空干燥粉末饮片的制备工艺
CN107397784A (zh) 一种鸡骨草鲜榨真空干燥粉末饮片的制备工艺
CN107397786A (zh) 一种连钱草鲜榨喷雾干燥粉末饮片的制备工艺
CN107334797A (zh) 一种凌霄花鲜榨喷雾干燥粉末饮片的制备工艺
CN107320527A (zh) 一种桑叶鲜榨真空干燥粉末饮片的制备工艺
CN107375353A (zh) 一种伸筋草鲜榨真空干燥粉末饮片的制备工艺

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20171219