CN107389961B - A kind of heating device applied to biosystem - Google Patents
A kind of heating device applied to biosystem Download PDFInfo
- Publication number
- CN107389961B CN107389961B CN201710701360.8A CN201710701360A CN107389961B CN 107389961 B CN107389961 B CN 107389961B CN 201710701360 A CN201710701360 A CN 201710701360A CN 107389961 B CN107389961 B CN 107389961B
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- heating
- heat
- biosystem
- connecting rod
- block
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
Abstract
The invention discloses a kind of heating devices applied to biosystem, including complete machine bracket, Re Gai, hot lid hoisting mechanism, heating module, anti-fouler, controller；The heat lid is arranged on complete machine bracket by hot lid hoisting mechanism, heating zone is constituted between heat lid and complete machine bracket, heating module is heated to heating zone, and the anti-fouler covers on the top of heating zone, and the hot lid hoisting mechanism, heating module and anti-fouler are connected with controller.Anti-fouler is devised in the present invention, when avoiding heating biosystem, the micro virus-like ontology leakage that biosystem generates pollutes the external world.
Description
Technical field
The present invention relates to a kind of technical field applied to heating device more particularly to a kind of adding applied to biosystem
Thermal.
Background technique
With the continuous development of molecular biology, fully automatic molecular diagnostic device using more and more common, automatically examine
Disconnected equipment often by the functions such as sample storage, sample preparation, response analysis, signal detection and analysis it is several together with, to make
It can detecte a variety of diseases；The device to biosystem heating existing at present, it is not right when being heated to sample
The device that the micropollution that biological sample generates is handled can generate biggish danger to experimenter during testing
Evil.
Summary of the invention
For above-mentioned harm, the present invention provides a kind of heating device applied to biosystem, adds in the present invention
Anti-fouler is filled, and during operating to sample, can be realized heat lid and open and close automatically, reduce artificial ginseng
It with amount, improves efficiency, and avoids during being heated to biosystem, the leakage of the small sample amount of generation, to the external world
It is polluted caused by air.
The technical proposal for solving the technical problem of the invention is as follows: a kind of heating device applied to biosystem,
Including complete machine bracket, Re Gai, hot lid hoisting mechanism, heating module, anti-fouler, controller；The heat lid passes through hot Gai Tisheng
Mechanism is arranged on complete machine bracket, and heating zone is constituted between heat lid and complete machine bracket, and heating module is heated to heating zone, described anti-
Dirty device covers on the top of heating zone, and the hot lid hoisting mechanism, heating module and anti-fouler are connected with controller.
Further, the hot lid hoisting mechanism includes side plate, fore-stock, pushing frame, lift block, first connecting rod, second
Connecting rod, straight line driving mechanism；A pair of side plates is symmetrically mounted on complete machine bracket, positioned at the two sides of heat lid, and the two sides of heat lid are solid
Surely there is lift block, the fore-stock and pushing frame are slidably arranged between a pair of side plates, one end of first connecting rod and lift block
Hingedly, the other end of first connecting rod and one end of second connecting rod are hinged, and the other end and pushing frame of second connecting rod are hinged, the heat
Covering at least has two linear guides, is equipped with the linear bearing matched with linear guide on the fore-stock, described to push away
Moving frame is driven by straight line driving mechanism.
Further, the heating module includes heating film, heat insulating block, TE cooling piece, heat block, sealed silicon adhesive tape；Institute
It states heating film to be fitted on heat insulating block, heat insulating block is fixedly connected on Re Gainei, and the heat block is fixed on complete machine bracket, is located at
The lower section of heat insulating block, the TE cooling piece are fitted in the lower surface of heat block；TE cooling piece and heating film are connected with controller.
Further, the anti-pollution of the installation includes cover, blower, high efficiency particulate air filter；The cover covers on heating zone
Top, so that the air in cover is flowed to high efficiency particulate air filter by blower.It is finally micro- by what is generated in biosystem heating process
The pollution of small sample amount is collected in high efficiency particulate air filter.
Further, there is limit locking part on the lift block.
Further, the two sides of the fore-stock are provided with guide groove, and one end of the first connecting rod and lift block are hinged
Hinged place is equipped with guide wheel, and the guide wheel is slidably arranged in guide groove.
Further, the straight line driving mechanism includes motor, feed screw nut, screw rod；The feed screw nut, which is fixed on, to push away
In moving frame, screw rod is installed on the feed screw nut, the screw rod is connected with the output shaft of motor, passes through motor driven pushing frame
It is slided along side plate.
Further, radiator is provided with below the heating zone.
Further, the radiator includes cooling fin, and the surface of heating zone is arranged in the cooling fin.
Further, radiator fan is arranged by the cooling fin.
Further, wind output channel is set at the exhaust outlet of the radiator fan.
Beneficial effects of the present invention are as follows:
1, the present invention realizes hot lid automatically open and close for the heating device of biosystem existing at present,
When being heated to biosystem, directly biosystem is placed on heating module, is then controlled by controller, heat lid
It moves forward and realizes automatic closure, reduce artificial participation in the process, improve efficiency.
2, during being heated to biosystem, since sample can generate micro wave to biosystem during heating
Hair, the gas to be volatilized can generate pollution；For this content, the heating device installation of biosystem of the present invention is anti-pollution, subtracts
Few pollution generated when biosystem is loaded, to external influence.
3, at radiator both ends, design has heat dissipation wind channel to the heating device of biosystem of the present invention, and heating module is heated
The heat generated in journey is exhausted directly to outside heating device by cooling fin, radiator fan, heat dissipation wind channel, reduces heating dress
Influence of the heat set to complete machine；Directly by the wind-force of radiator fan during again, heat that heating module is generated into
Row forced-ventilated, complete machine do not spend the other radiators of increase.
Detailed description of the invention
Fig. 1 is the axonometric schematic diagram of the embodiment of the present invention；
Fig. 2-Fig. 5 is the axonometric schematic diagram of the embodiment of the present invention (without anti-fouler)；
Fig. 6 is the axonometric schematic diagram of latus inframedium of the embodiment of the present invention；
Fig. 7 is cross-sectional view in the embodiment of the present invention；
In figure: complete machine bracket 1, hot lid 2, hot lid hoisting mechanism 3, heating module 4, anti-fouler 5, radiator 6, heating
Area 7, side plate 301, fore-stock 302, pushing frame 303, lift block 304, first connecting rod 305, second connecting rod 306, straight line driving
Structure 307, first pulley 308, linear guide 309, linear bearing 310, second pulley 311, horizontal concrete chute 3011, vertical sliding slot
3012, guide groove 3021, motor 3071, feed screw nut 3072, screw rod 3073, limit locking part 3041, third pulley 3042, heating
Film 401, heat insulating block 402, TE cooling piece 403, heat block 404, sealed silicon adhesive tape 405, cover 501, blower 502, high efficiency filter
Device 503, ventilation duct 504, cooling fin 601, radiator fan 602, wind output channel 603.
Specific embodiment
Example embodiments are described in detail here, and the example is illustrated in the accompanying drawings.Following description and attached
When figure, unless otherwise indicated, the same numbers in different drawings indicate the same or similar elements.In following exemplary embodiment
Described embodiment does not represent all embodiments consistented with the present invention.On the contrary, they be only with it is such as appended
It is described in detail in middle claims, the example of the consistent device of some aspects of the invention.Each implementation of this specification
Example is described in a progressive manner.
It is to be appreciated that the directional instruction (such as up, down, left, right, before and after ...) of institute is only used in the embodiment of the present invention
In explaining in relative positional relationship, the motion conditions etc. under a certain particular pose (as shown in the picture) between each component, if should
When particular pose changes, then directionality instruction also correspondingly changes correspondingly.
In addition, the description for being related to " first ", " second " etc. in the present invention is used for description purposes only, and should not be understood as referring to
Show or imply its relative importance or implicitly indicates the quantity of indicated technical characteristic." first ", " are defined as a result,
Two " feature can explicitly or implicitly include at least one of the features.In addition, the technical solution between each embodiment can
It to be combined with each other, but must be based on can be realized by those of ordinary skill in the art, when the combination of technical solution occurs
Conflicting or cannot achieve when, will be understood that the combination of this technical solution is not present, also not the present invention claims protection model
Within enclosing.
The biosystem of present apparatus heating, is a kind of silicon chip with micro-aperture, the sample liquid body sheet that needs are detected
It is uniform to apply on the silicon die, micro-aperture is automatically flowed by gravity liquid sample, then by entire sample and silicon core
Piece is packaged, and is formed a biosystem, is then heated.
As shown in figs. 1-7, a kind of heating device applied to biosystem, including complete machine bracket 1, hot lid 2, hot Gai Tisheng
Mechanism 3, heating module 4, anti-fouler 5, radiator 6, controller；The hot lid 2 is arranged by hot lid hoisting mechanism 3 whole
On machine support 1, the folding of hot lid 2 is realized by hot lid hoisting mechanism 3；Heating zone 7 is constituted between hot lid 2 and complete machine bracket 1, it will
The biosystem for needing to expand, which is placed, to be heated with heating zone 7, heating module 4 to heating zone 7, and the anti-fouler 5 covers on heating
The top in area 7, for amplification procedure is neutralized/or amplification after the completion of promote hot lid 2 when the biosystem that comes out produced
The gas of raw trace sample leakage is guided into anti-fouler 5, is carried out by the high efficiency particulate air filter 503 in anti-fouler 5
Filter and collection；The hot lid hoisting mechanism 3, heating module 4 and anti-fouler 5 are connected with controller.
As shown in Figure 1, the anti-fouler 5 includes cover 501, blower 502, high efficiency particulate air filter 503；The cover 501
The top for covering on heating zone 7 makes the air in cover 501 flow to high efficiency particulate air filter 503 by blower 502.The wind speed of blower 502
It is controlled by controller.In the present embodiment, the outlet of cover 501 connects ventilation duct 504, and wind is arranged in the exit of ventilation duct 504
High efficiency particulate air filter 503, the front-rear position of certain high efficiency particulate air filter 503 and blower 502 is arranged in the exit of blower 502 in machine 502
It can also exchange.
As shown in Figure 2-5, the hot lid hoisting mechanism 3 includes side plate 301, fore-stock 302, pushing frame 303, lift block
304, first connecting rod 305, second connecting rod 306, straight line driving mechanism 307；A pair of side plates 301 is symmetrically mounted on complete machine bracket 1,
Positioned at the two sides of hot lid 2, the two sides of hot lid 2 are respectively and fixedly provided with lift block 304, and the fore-stock 302 and pushing frame 303 are in U
Shape, the fore-stock 302 and pushing frame 303 are slidably arranged between a pair of side plates 301, the fore-stock 302 and pushing frame
303 both ends are mounted at least two first pulleys 308, and identical horizontal concrete chute 3011 is provided on the side plate 301 and is hung down
Straight runner 3012, as shown in Figure 6；The first pulley 308 is slidably arranged in horizontal concrete chute 3011, passes through first pulley
308 design, reduces sliding friction；One end of first connecting rod 305 and lift block 304 are hinged, the other end of first connecting rod 305
Hinged with one end of second connecting rod 306, the other end and pushing frame 303 of second connecting rod 306 are hinged, at least have on the hot lid 2
There are two linear guides 309, the linear bearing 310 matched with linear guide 309, heat lid are installed on the fore-stock 302
2, linear guide 309 and linear bearing 310 constitute slide block mechanism, and the pushing frame 303 is driven by straight line driving mechanism 307.
The straight line driving mechanism 307 includes motor 3071, feed screw nut 3072, screw rod 3073；The feed screw nut
3072 are fixed in pushing frame 303, and screw rod 3073, the screw rod 3073 and motor 3071 are equipped on the feed screw nut 3072
Output shaft be connected, by motor 3071 drive pushing frame 303 along side plate 301 slide.Motor 3071 is controlled by controller.Directly
The power that line driving mechanism 307 exports drives lift block 304 along linear bearing 310 by first connecting rod 305 and second connecting rod 306
It moves up and down, to realize moving up and down for hot lid 2；In the process, first connecting rod 305 passes to 304 1 water of lift block
Flat component and component straight up, component straight up are linear guides 309 on hot lid 2 relative to linear bearing
The power of 310 slidings, and horizontal component then makes linear guide 309 generate a moment of flexure relative to linear bearing 310, if not disappearing
Except moment of flexure, over time will necessarily excessive wear, part distortion, thus error increase；In order to eliminate moment of flexure, the present invention is in preceding branch
The two sides of frame 302 are provided with guide groove 3021, and the hinged place that one end of the first connecting rod 305 is hinged with lift block 304 is equipped with
Second pulley 311, the second pulley 311 are slidably arranged in guide groove 3021, resist guide groove 3021 by second pulley 311
It avoids, to eliminate horizontal component.
By the driving of straight line driving mechanism 307, fore-stock 302 and pushing frame 303 can be moved forward along side plate 301 or
It moves backward, when moving backward, hot lid 2 is elevated, and heating zone 7 is opened；When forward movement, hot lid 2 declines, and heating zone 7 is closed
It closes, is expanded；The position that hot lid 2 drops to lowermost end is arranged in heating zone 7 by the present invention；Since slide block mechanism passes through screw rod
3073 drivings are in lowermost end in the hot lid 2 in two positions, although can by the screw rod transmission in the driving of straight line driving mechanism 307
Realize accurately controlling for displacement, but to be on the safe side, the present invention has limit locking part 3041 on lift block 304,
Third pulley 3042 is installed, third pulley 3042 is arranged in vertical sliding slot 3012, when hot lid 2 in limit locking part 3041
When being thus lifted to top, third pulley 3042 is in topmost (i.e. vertical sliding slot 3012 and the level cunning of vertical sliding slot 3012
The intersection of slot 3011), when hot lid 2 is delegated to bottom, third pulley 3042 is in the lowest part of vertical sliding slot 3012,
It is arranged by third pulley 3042 in vertical sliding slot 3012, limits the extreme position moved before fore-stock 302.
The lower section of the heating zone 7 is provided with radiator 6；Radiator 6 described in the present embodiment includes cooling fin
601, the surface of heating zone 7, the radiator fan 602 is arranged in radiator fan 602, wind output channel 603, the cooling fin 601
Be arranged in by cooling fin 601, wind output channel 603 be set at the exhaust outlet of the radiator fan 602, the radiator fan 602 with
Controller is connected, and the wind speed and on-off of radiator fan 602 are controlled by controller.
As shown in fig. 7, the heating module 4 include heating film 401, heat insulating block 402, TE cooling piece 403, heat block 404,
Sealed silicon adhesive tape 405；The heating film 401 is fitted on heat insulating block 402, and heat insulating block 402 is fixedly connected in hot lid 2, described
Heat block 404 is fixed on complete machine bracket 1, positioned at the lower section of heat insulating block 402, and the TE cooling piece 403 is fitted in heat block 404
Lower surface；TE cooling piece 403 and heating film 401 are connected with controller, control TE cooling piece 403 and heating film 401 carries out
Work.In order to keep 7 airtightness of heating zone more preferable, sealed silicon adhesive tape 405 is installed at the edge of hot lid 2, makes entire 4 shape of heating module
At a seal cavity, to preferably be heated to biosystem.The TE cooling piece 403 is mainly used for adding for biosystem
The heat source and refrigeration source of heat, the heat that TE cooling piece 403 generates are transmitted by heat-conducting block 404, eventually for real to biosystem
It now heats, after the completion of heating, TE cooling piece 403 freezes to heat-conducting block 404, freezes to realize to biosystem；Heating
The heat of film 401 is primarily to balance the uniform of entire 7 internal temperature of biosystem heating zone, when the 403 pairs of lifes of TE cooling piece
When object system is heated, the temperature below the temperature of entire heating zone 7 is higher than temperature above at this time, in order to avoid in biology
The upper surface of system condenses, to devise heating film 401 and heat insulating block 402.Control as embodiment, in the present invention
Device can use the DVP14SS211T product of DELTA Delta board, but not limited to this.
The course of work of the invention is as follows:
Firstly, motor 3071 rotates forward, screw rod 3073 is driven to rotate, 3072 engaged transmission of screw rod 3073 and feed screw nut will
Rotary motion is converted to linear motion, arrives right end so that pushing frame 303 be drawn, pushing frame 303 drives second connecting rod 306 and the
One connecting rod 305, first connecting rod 305 pull up hot lid 2 along linear bearing 310, and simultaneously, fore-stock 302, which also follows, to be pushed away
Moving frame 303 is slided to the right, and heating zone 7 is opened, and the biosystem heated will be needed to be placed in heating zone 7；
Motor 3071 inverts, and fore-stock 302 and pushing frame 303 are mobile to the left side, and when being moved to left end, hot lid 2 is by under
Side, heating zone 7 are closed, and are opened heating module 4 and are expanded, while opening radiator fan 602 and blower 502, and blower 502 will expand
The gas that trace sample caused by biosystem is revealed in increasing process pumps to high efficiency particulate air filter 503, avoids biosystem shape
At sample leakage gas polluted caused by outside air.Radiator fan 602 radiates to cooling fin 601, passes through air draft
The heat formed during heating is all discharged to outside complete machine by air duct 603, avoids influence of the heat to complete machine.
After completing amplification, motor 3071 is rotated forward, and hot lid 2 is elevated, and heating zone 7 is opened, and takes out biosystem.
Claims (8)
1. a kind of heating device applied to biosystem, which is characterized in that including complete machine bracket, Re Gai, hot lid hoisting mechanism,
Heating module, anti-fouler, controller；The heat lid is arranged on complete machine bracket by hot lid hoisting mechanism, heat lid and complete machine
Heating zone is constituted between bracket, heating module is heated to heating zone, and the anti-fouler covers on the top of heating zone, the heat lid
Hoisting mechanism, heating module and anti-fouler are connected with controller；
The hot lid hoisting mechanism includes side plate, fore-stock, pushing frame, lift block, first connecting rod, second connecting rod, linear drives
Mechanism；A pair of side plates is symmetrically mounted on complete machine bracket, positioned at the two sides of heat lid, and the two sides of heat lid are respectively and fixedly provided with lift block, institute
It states fore-stock and pushing frame is slidably arranged between a pair of side plates, one end of first connecting rod and lift block are hinged, first connecting rod
The other end and second connecting rod one end it is hinged, the other end and pushing frame of second connecting rod are hinged, and the heat, which covers, at least to be had
Two linear guides are equipped with the linear bearing matched with linear guide on the fore-stock, and the pushing frame passes through straight line
Driving mechanism driving；
The two sides of the fore-stock are provided with guide groove, and one end of first connecting rod hinged place hinged with lift block, which is equipped with, leads
Wheel, the guide wheel are slidably arranged in guide groove.
2. a kind of heating device applied to biosystem according to claim 1, which is characterized in that the heating module
Including heating film, heat insulating block, TE cooling piece, heat block, sealed silicon adhesive tape；The heating film is fitted on heat insulating block, heat insulating block
It is fixedly connected on Re Gainei, the heat block is fixed on complete machine bracket, positioned at the lower section of heat insulating block, the TE cooling piece fitting
In the lower surface of heat block；TE cooling piece and heating film are connected with controller.
3. a kind of heating device applied to biosystem according to claim 1, which is characterized in that the anti-fouler
Including cover, blower, high efficiency particulate air filter；The cover covers on the top of heating zone, flows to the air in cover by blower
High efficiency particulate air filter.
4. a kind of heating device applied to biosystem according to claim 1, which is characterized in that on the lift block
With limit locking part.
5. a kind of heating device applied to biosystem according to claim 1, which is characterized in that the linear drives
Mechanism includes motor, feed screw nut, screw rod；The feed screw nut is fixed in pushing frame, is equipped with silk on the feed screw nut
Bar, the screw rod are connected with the output shaft of motor.
6. a kind of heating device applied to biosystem according to claim 1, which is characterized in that the heating zone
Lower section is provided with radiator.
7. a kind of heating device applied to biosystem according to claim 6, which is characterized in that the radiator
Including cooling fin, the surface of heating zone is arranged in the cooling fin, arranges radiator fan by the cooling fin.
8. a kind of heating device applied to biosystem according to claim 7, which is characterized in that the radiator fan
Exhaust outlet at be arranged wind output channel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710701360.8A CN107389961B (en) | 2017-08-16 | 2017-08-16 | A kind of heating device applied to biosystem |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710701360.8A CN107389961B (en) | 2017-08-16 | 2017-08-16 | A kind of heating device applied to biosystem |
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| Publication Number | Publication Date |
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| CN107389961A CN107389961A (en) | 2017-11-24 |
| CN107389961B true CN107389961B (en) | 2019-11-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710701360.8A Active CN107389961B (en) | 2017-08-16 | 2017-08-16 | A kind of heating device applied to biosystem |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115637213B (en) * | 2022-12-23 | 2023-04-07 | 鲲鹏基因（北京）科技有限责任公司 | A hot lid device and PCR appearance for PCR appearance |
| CN115637224B (en) * | 2022-12-23 | 2023-03-31 | 鲲鹏基因（北京）科技有限责任公司 | PCR instrument |
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| CN105039155A (en) * | 2015-07-29 | 2015-11-11 | 杭州安杰思生物科技有限公司 | Real-time fluorescent quantitative PCR instrument |
| CN107015584A (en) * | 2017-05-16 | 2017-08-04 | 杭州电子科技大学 | A kind of temperature control device and control method applied to nucleic acid amplification technologies |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07308183A (en) * | 1994-05-17 | 1995-11-28 | Sanyo Electric Co Ltd | Apparatus for sterilizing incubator |
| CN2351779Y (en) * | 1998-09-29 | 1999-12-01 | 杭州大和热磁电子有限公司 | Gene magnification instrument |
| CN1506452A (en) * | 2002-12-09 | 2004-06-23 | ������������ʽ���� | Incubator |
| CN201045140Y (en) * | 2006-12-27 | 2008-04-09 | 甘宜梧 | Organism safe incubator |
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| CN104630057A (en) * | 2015-03-05 | 2015-05-20 | 东南大学 | Full-automatic thermal cycler hot cover |
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Address after: 310020 room 341, Jin Jun building, 1114 Xiang Xiang Road, Hangzhou, Zhejiang, Jianggan District Applicant after: Pilot Gene Technology (Hangzhou) Co., Ltd. Address before: 310020 room 341, Jin Jun building, 1114 Xiang Xiang Road, Hangzhou, Zhejiang, Jianggan District Applicant before: East China Medicine (Hangzhou) Gene Technology Co., Ltd. |
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Effective date of registration: 20211207 Address after: 518000 g1316, Lianxing building, building B, Yihua new village, district 46, Haifu community, Xin'an street, Bao'an District, Shenzhen, Guangdong Province Patentee after: Pilot medical technology (Shenzhen) Co.,Ltd. Address before: Room 1114, Jinjun building, 341 Shuixiang Road, Jianggan District, Hangzhou City, Zhejiang Province, 310020 Patentee before: PILOT GENE TECHNOLOGIES (HANGZHOU) Co.,Ltd. |