CN107375424A - 一种荆芥鲜榨真空干燥粉末饮片及其制备工艺 - Google Patents
一种荆芥鲜榨真空干燥粉末饮片及其制备工艺 Download PDFInfo
- Publication number
- CN107375424A CN107375424A CN201710739115.6A CN201710739115A CN107375424A CN 107375424 A CN107375424 A CN 107375424A CN 201710739115 A CN201710739115 A CN 201710739115A CN 107375424 A CN107375424 A CN 107375424A
- Authority
- CN
- China
- Prior art keywords
- schizonepeta
- fresh
- squeeze
- concoction
- vacuum drying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000951473 Schizonepeta Species 0.000 title claims abstract description 51
- 239000000843 powder Substances 0.000 title claims abstract description 16
- 238000001291 vacuum drying Methods 0.000 title claims abstract description 16
- 238000005516 engineering process Methods 0.000 title claims abstract description 10
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000003756 stirring Methods 0.000 claims abstract description 10
- 239000000341 volatile oil Substances 0.000 claims abstract description 5
- 239000003921 oil Substances 0.000 claims description 13
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 8
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 8
- 229920000858 Cyclodextrin Polymers 0.000 claims description 4
- 239000001116 FEMA 4028 Substances 0.000 claims description 4
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 4
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 4
- 229960004853 betadex Drugs 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- 238000009461 vacuum packaging Methods 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 17
- 239000004480 active ingredient Substances 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 3
- 230000000192 social effect Effects 0.000 abstract description 2
- 238000001914 filtration Methods 0.000 abstract 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 238000002386 leaching Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- 238000001035 drying Methods 0.000 description 4
- 238000000605 extraction Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 206010013786 Dry skin Diseases 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公布了一种荆芥鲜榨真空干燥粉末饮片及其制备工艺。该工艺在荆芥药材采收后，净选、淋洗，并趁鲜压榨，滤取药汁。药渣再加水搅拌，过滤压榨。所得药汁合并后减压浓缩，真空干燥；浓缩冷凝液分离挥发油，并与真空干燥物混合，过筛装袋。此法制备的荆芥粉末饮片，最大限度的保留了药材中的有效成分。饮片便于储运，方便调剂，质量可控，疗效可靠，对保障中医药临床疗效具有重要的意义。本法的推广实施，将有显著的社会意义和经济效益。
Description
技术领域
本发明属于中药材加工领域，尤其涉及中药荆芥饮片的加工工艺。
背景技术
中药荆芥为唇形科植物荆芥Schizonepeta tenuisfolia Briq. 的干燥地上部分。本品味平，性温，无毒，清香气浓，富含挥发性成分。荆芥为发汗，解热药，是中医常用草药之一，有镇痰、祛风、凉血之效。临床主要用来治流行感冒，头疼寒热发汗，呕吐。
常用的荆芥饮片的加工方式为：割取地上部分，切碎，阴干或晒干入药；或者经整理、晒干后，打包储藏和运输。这些干燥的荆芥药材运送到中药饮片厂后，需要淋洗、切片，并重新晒干。现有工艺耗时费力，工序重复，增加了饮片的生产成本。在此过程中不仅会导致其中的水溶性的大量流失，而且其丰富的挥发性有效成分也大量的逸散，从而导致药材品质的下降和临床疗效的降低。此类草药饮片，体积庞大，容易污染和霉变，质量很难保证，不利于配方调剂和确保其临床疗效。
目前，市场上也有荆芥药材经过提取后制成的颗粒饮片销售。由于颗粒饮片制备过程中，提取不仅耗时耗能，而且因常用水做溶媒，药材中的非极性有效成分很难被提取出来。此外，由于提取用的荆芥药材也是干燥并经过长时间储藏的，因此，有效成分的损失也是很大的。为了确保荆芥药材的临床有效、质量稳定，一种新型的荆芥饮片及其制备工艺亟待开发。
发明内容
本发明公布了 “一种荆芥鲜榨真空干燥粉末饮片及其制备工艺”。本工艺可以最大限度的保留荆芥药材中的极性和非极性有效成分，避免药材在现有的饮片加工和储运过程中引起的有效成分的丢失和药材品质的下降，减少药材受霉菌等的污染，对确保荆芥饮片的质量稳定和临床安全有效具有重要的意义。
为了实现上述目的，本发明的技术方案为：
在荆芥采收期采集其地上部分，洗净，切成1~2cm的段，加入药材重量0.5~1倍量的水，搅拌15~30分钟，趁鲜压榨，收集初榨药汁，药渣加入1~5倍量的水，搅拌5~30min，压榨取汁，所剩药渣再加入1~5倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100~200目筛过滤，得荆芥药汁。将荆芥药汁，于40~65℃减压浓缩，得到相对密度为1.05~1.30的浸膏于40~60℃真空干燥4~8小时后粉碎。同时，收集减压浓缩所得的荆芥冷凝水，加入荆芥冷凝水重量20%~30%的NaCl，搅拌使溶解，溶液置油水分离器中，于4℃~10℃环境下放置12~48小时，收集上部油层，得荆芥挥发油，将此用挥发油重量5~10倍的β-环糊精包合，并将包合物与权利要2中的荆芥真空干燥粉混合均匀，过40~100目筛，真空包装，即得荆芥鲜榨真空干燥粉末饮片。
在产品包装袋的标签上，印刷上品名、药用部位、种植地、生产商、生产日期、主要成分含量、性味归经、功能主治、用法用量、毒副作用及禁忌证等信息。袋内附上荆芥的薄层鉴别图谱和/或高效液相特征图谱，作为产品的“身份证”。此外，在产品的包装袋上，印有二维码，通过扫描可以链接获取产品的原植物照片、药材照片、饮片照片、性状及显微鉴别特征等信息。
本发明的有益之处在于：
新鲜荆芥药材净选洗涤后直接切段压榨、过滤、减压浓缩、真空干燥、分离油、混合，所得到的粉末饮片，可以最大限度地完整保留药材中的有效成分。 这种饮片体积较之于传统饮片体积大大地减小，质量更加稳定，利于储运和临床调剂，具有十分显著的社会意义和经济意义。
具体实施方式
实施例1
将新鲜采集的荆芥药材，洗净，切成1cm的段，加入药材重量0.5倍量的水，搅拌15分钟，趁鲜压榨，收集初榨药汁，药渣加入5倍量的水，搅拌5min，压榨取汁，所剩药渣再加入5倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100目筛过滤，得荆芥药汁。将荆芥药汁，减压浓缩，温度设定为65℃。在浓缩所得浸膏相对密度为1.15时，转移到真空干燥箱内，于60℃干燥6小时，得真空干燥物。另外，将减压浓缩时收集的荆芥冷凝水，加入其重量20%的NaCl，搅拌使溶解，溶液置油水分离器中，于4℃环境下放置48小时，收集上部油层，得荆芥挥发油。将此用挥发油重量5倍的β-环糊精包合，并将包合物，再与荆芥真空干燥粉混合均匀，过60目筛，真空包装，即得荆芥鲜榨真空干燥粉末饮片。
实施例2
将新鲜采集的荆芥药材，洗净，切成2cm的段，加入药材重量1倍量的水，搅拌30分钟，趁鲜压榨，收集初榨药汁，药渣加入5倍量的水，搅拌10min，压榨取汁，所剩药渣再加入4倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，200目筛过滤，得荆芥药汁。将荆芥药汁，减压浓缩，温度设定为70℃。在浓缩所得浸膏相对密度为1.10时，转移到真空干燥箱内，于70℃干燥6小时，得真空干燥物。另外，将减压浓缩时收集的荆芥冷凝水，加入其重量30%的NaCl，搅拌使溶解，溶液置油水分离器中，于10℃环境下放置48小时，收集上部油层，得荆芥挥发油。将此用挥发油重量6倍的β-环糊精包合，并将包合物，再与荆芥真空干燥粉混合均匀，过60目筛，真空包装，即得荆芥鲜榨真空干燥粉末饮片。
以上实施例，仅为说明本项发明的技术思想，不能凭此限定本发明的保护范围 凡是按照本发明提出的技术思想，在技术方案基础上所做的任何改动，均落入本发明保护的范围之内。
Claims (3)
1.一种荆芥鲜榨真空干燥粉末饮片及其制备工艺，其特征在于：在荆芥采收期采集其地上部分，洗净，切成1~2cm的段，加入药材重量0.5~1倍量的水，搅拌15~30分钟，趁鲜压榨，收集初榨药汁，药渣加入1~5倍量的水，搅拌5~30min，压榨取汁，所剩药渣再加入1~5倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100~200目筛过滤，得荆芥药汁。
2.根据权利要求1所述的一种荆芥鲜榨真空干燥粉末饮片及其制备工艺，其特征在于：将权利要求1中所得的荆芥药汁，40~65℃减压浓缩，所得相对密度为1.05~1.30的浸膏于40~60℃真空干燥4~8小时后粉碎。
3.根据权利要求1所述的一种荆芥鲜榨真空干燥粉末饮片及其制备工艺，其特征在于：收集权利要求2中的减压浓缩所得的荆芥冷凝水，加入荆芥冷凝水重量20%~30%的NaCl，搅拌使溶解，溶液置油水分离器中，于4℃~10℃环境下放置12~48小时，收集上部油层，得荆芥挥发油，将此用挥发油重量5~10倍的β-环糊精包合，并将包合物与权利要2中的荆芥真空干燥粉混合均匀，过40~100目筛，真空包装，即得荆芥鲜榨真空干燥粉末饮片。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739115.6A CN107375424A (zh) | 2017-08-25 | 2017-08-25 | 一种荆芥鲜榨真空干燥粉末饮片及其制备工艺 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739115.6A CN107375424A (zh) | 2017-08-25 | 2017-08-25 | 一种荆芥鲜榨真空干燥粉末饮片及其制备工艺 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107375424A true CN107375424A (zh) | 2017-11-24 |
Family
ID=60346013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710739115.6A Pending CN107375424A (zh) | 2017-08-25 | 2017-08-25 | 一种荆芥鲜榨真空干燥粉末饮片及其制备工艺 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107375424A (zh) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998133A (zh) * | 2016-07-23 | 2016-10-12 | 徐漫 | 一种半边莲鲜榨真空干燥粉末饮片及其制备工艺 |
| CN105998167A (zh) * | 2016-07-23 | 2016-10-12 | 徐自升 | 一种槐花鲜榨真空干燥粉末饮片及其制备工艺 |
| CN106109532A (zh) * | 2016-07-23 | 2016-11-16 | 徐自升 | 一种金银花鲜榨真空干燥粉末饮片及其制备工艺 |
| CN107050082A (zh) * | 2017-06-19 | 2017-08-18 | 徐漫 | 一种小蓟鲜榨真空干燥粉末饮片及其制备工艺 |
-
2017
- 2017-08-25 CN CN201710739115.6A patent/CN107375424A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998133A (zh) * | 2016-07-23 | 2016-10-12 | 徐漫 | 一种半边莲鲜榨真空干燥粉末饮片及其制备工艺 |
| CN105998167A (zh) * | 2016-07-23 | 2016-10-12 | 徐自升 | 一种槐花鲜榨真空干燥粉末饮片及其制备工艺 |
| CN106109532A (zh) * | 2016-07-23 | 2016-11-16 | 徐自升 | 一种金银花鲜榨真空干燥粉末饮片及其制备工艺 |
| CN107050082A (zh) * | 2017-06-19 | 2017-08-18 | 徐漫 | 一种小蓟鲜榨真空干燥粉末饮片及其制备工艺 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107412303A (zh) | 一种佩兰鲜榨真空干燥粉末饮片的制备工艺 | |
| CN105213474A (zh) | 一种薄荷鲜榨喷雾干燥颗粒饮片及其制备工艺 | |
| CN107432883A (zh) | 一种透骨草鲜榨真空干燥粉末饮片的制备工艺 | |
| CN106074687A (zh) | 一种冬凌草鲜榨真空干燥粉末饮片及其制备工艺 | |
| CN106074686A (zh) | 一种冬凌草鲜榨喷雾干燥颗粒饮片及其制备工艺 | |
| CN106109566A (zh) | 一种冬凌草鲜榨冷冻干燥粉末饮片及其制备工艺 | |
| CN107050113A (zh) | 一种辛夷花鲜榨喷雾干燥粉末饮片及其制备工艺 | |
| CN107157937A (zh) | 一种藿香鲜榨喷雾干燥颗粒饮片及其制备工艺 | |
| CN107397789A (zh) | 一种荆芥鲜榨喷雾干燥粉末饮片及其制备工艺 | |
| CN107375424A (zh) | 一种荆芥鲜榨真空干燥粉末饮片及其制备工艺 | |
| CN105641037A (zh) | 一种苏叶鲜榨喷雾干燥粉末饮片及其制备工艺 | |
| CN107485633A (zh) | 一种艾叶鲜榨喷雾干燥粉末饮片的制备工艺 | |
| CN107157939A (zh) | 一种辛夷花鲜榨冷冻干燥粉末饮片及其制备工艺 | |
| CN107375425A (zh) | 一种荆芥鲜榨冷冻干燥粉末饮片及其制备工艺 | |
| CN107397774A (zh) | 一种芫荽鲜榨冷冻干燥粉末饮片的制备工艺 | |
| CN107397788A (zh) | 一种荆芥鲜榨喷雾干燥颗粒饮片及其制备工艺 | |
| CN107260797A (zh) | 一种藿香鲜榨真空干燥粉末饮片及其制备工艺 | |
| CN107441136A (zh) | 一种佩兰鲜榨喷雾干燥粉末饮片的制备工艺 | |
| CN107320514A (zh) | 一种佩兰鲜榨冷冻干燥粉末饮片的制备工艺 | |
| CN107213195A (zh) | 一种藿香鲜榨冷冻干燥粉末饮片及其制备工艺 | |
| CN107375489A (zh) | 一种橘叶鲜榨喷雾干燥粉末饮片及其制备工艺 | |
| CN107456473A (zh) | 一种大丁草鲜榨真空干燥粉末饮片的制备工艺 | |
| CN107334849A (zh) | 一种橘叶鲜榨真空干燥粉末饮片及其制备工艺 | |
| CN107224456A (zh) | 一种藿香鲜榨喷雾干燥粉末饮片及其制备工艺 | |
| CN107375378A (zh) | 一种大丁草鲜榨喷雾干燥粉末饮片的制备工艺 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171124 |
|
| WD01 | Invention patent application deemed withdrawn after publication |