CN107362323A - A kind of preparation for improving sleep and preparation method thereof - Google Patents
A kind of preparation for improving sleep and preparation method thereof Download PDFInfo
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- CN107362323A CN107362323A CN201710647384.XA CN201710647384A CN107362323A CN 107362323 A CN107362323 A CN 107362323A CN 201710647384 A CN201710647384 A CN 201710647384A CN 107362323 A CN107362323 A CN 107362323A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/235—Foeniculum (fennel)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Abstract
A kind of preparation for improving sleep and preparation method thereof, is related to field of medicaments.A kind of preparation for improving sleep, raw material include：The cardamom of 20~35 parts by weight, cardamom includes Amomum cardamomum and nutmeg is one or two kinds of；The pepper of 10~25 parts by weight and/or Bi are dialled, and pepper includes at least one of black pepper and white pepper；At least one of the fennel seeds of 20~40 parts by weight, Carum carvi, cumin.Said preparation can significantly improve the sleep of human body, improve the sleep quality of human body.The preparation method of preparation, it includes：Raw material is used into supercritical CO2Volatile oil and the dregs of a decoction is obtained by extraction, medicinal extract is made in the extraction of dregs of a decoction ethanol, by volatile oil, medicinal extract and pharmaceutic adjuvant mixing granulation.The preparation method is simple, takes full advantage of raw material, good the effect of the preparation prepared.
Description
Technical field
The present invention relates to field of medicaments, and more particularly to a kind of preparation for improving sleep and preparation method thereof.
Background technology
With work, the quickening of rhythm of life, the life of people, operating pressure increasingly increase.Thus caused insomnia, suppression
The problems such as strongly fragrant, turns into the significant problem for seriously endangering human health.According to the investigation of the World Health Organization, about 27% people, sleep
In the presence of it is different degrees of the problem of.CSRS in 2003 is up to national 40,000 parts of questionnaire statistical result showeds
The insomnia of 38.2% Chinese Urban Residents various degrees, higher than the ratio in the world 27%.
The medicine of Modern medical therapy insomnia mainly has benzodiazepine and Non-benzodiazepine medicine, and other
Medicine (including anxiolytic drugs, antidepressant, epiphysin and hormone medicine) to conduce to sleep etc..Said medicine is universal
With strong, the easy habituation of drug dependence, it is also easy to produce the defects of drug resistance.Long-term use of patient once be discontinued occur look forward or upwards it is absurd,
Epilepsy seizure, tremble, perspire and the symptoms such as appetite is deteriorated, therefore, market in urgent need is without pharmacological dependence, safe and reliable and sleeping
The health products of positive effect.
The content of the invention
It is an object of the invention to provide a kind of preparation for improving sleep, said preparation can significantly improve the sleep of human body, carry
The sleep quality of high human body.
Another object of the present invention is to provide a kind of preparation method for the preparation for improving sleep, the preparation method is simple,
Raw material is taken full advantage of, it is good the effect of the preparation prepared.
The present invention is solved its technical problem and realized using following technical scheme.
The present invention proposes a kind of preparation for improving sleep, and raw material includes：
The cardamom of 20~35 parts by weight, cardamom include at least one of Amomum cardamomum and nutmeg；
The pepper of 10~25 parts by weight and/or Bi are dialled, and pepper includes at least one of black pepper and white pepper；
At least one of the fennel seeds of 20~40 parts by weight, Carum carvi, cumin.
The present invention proposes a kind of preparation method for the preparation for improving sleep, and it includes：Raw material is mixed.
The present invention proposes a kind of preparation method for the preparation for improving sleep, and it includes：Raw material is used into supercritical CO2Extraction
Volatile oil and the dregs of a decoction are obtained, wherein, extracting pressure 25MPa~30MPa, 40~60 DEG C of extraction temperature, CO26~10kg/h of flow,
60~120min of extraction time；Medicinal extract is made in the extraction of dregs of a decoction ethanol, by volatile oil, medicinal extract and pharmaceutic adjuvant mixing granulation.
A kind of beneficial effect of preparation and preparation method thereof for improving sleep proposed by the present invention is：It is a kind of to improve what is slept
Preparation, cardamom, pepper and the/Bi that raw material contains abundant volatile oil active component are dialled, Carum carvi and/or cumin and/or small
Fennel.Tibetanmedicine is thought, cardamom middle benefit gas promoting the circulation of qi, presses down grand disease, controls insomnia；Pepper and/Bi are dialled, warming spleen and stomach for dispelling cold, stomach invigorating；Cumin,
Warm stomach invigorating the spleen, control the grand disease of lifeblood；Grand disease, the grand diseases of You Zhixin and cardiopyretic syndrome are planted by Carum carvi and fennel seeds, Zhiduo County；Make three on the whole
Big factor balance, so as to improve the sleep of body.Again, the reasonable mixture ratio between the raw material of said preparation, can under the proportioning
Play maximum synergy；Simultaneously because said preparation formula is simple, raw material is few, and said preparation has no toxic side effect, and patient is not easy
Produce dependence.
The preparation method of above-mentioned preparation, simply, rationally make use of raw material, farthest extract and retain volatility into
Point, it ensure that the stability of preparation；Simultaneously said preparation carry take convenient, dosage with it is quality controllable.
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical scheme be clearly and completely described.Unreceipted actual conditions person, builds according to normal condition or manufacturer in embodiment
The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, it is the conventional production that can be obtained by commercially available purchase
Product.
Preparation of a kind of improvement sleep to the embodiment of the present invention and preparation method thereof is specifically described below.
A kind of preparation for improving sleep provided in an embodiment of the present invention, raw material include：The cardamom of 25~35 parts by weight, cardamom
Including one or both of Amomum cardamomum and nutmeg；The pepper of 15~25 parts by weight and/or Bi are dialled, pepper include black pepper and
At least one of white pepper；At least one of the fennel seeds of 20~40 parts by weight, Carum carvi, cumin.
Preferably, raw material includes 22~32 parts by weight cardamoms, and the pepper of 16~22 parts by weight and/or Bi are dialled, 25~33 weights
Measure at least one of fennel seeds, Carum carvi, cumin of part.
Preferably, raw material includes the nutmeg of 30 parts by weight, and the pepper of 20 parts by weight and/or Bi are dialled, 20 parts by weight
At least one of cumin, the fennel seeds of 30 parts by weight, Carum carvi, cumin.
Cardamom nature and flavor Wen Xin, have in warm spleen stomach invigorating, promoting the circulation of qi tune, help digestion and other effects.In the present embodiment, cardamom includes white
Cardamom and/or nutmeg.Amomum cardamomum (Fmctus Amomi Rotundus) is the drying and ripening of Zingiber cardamom platymiscium Amomum cardamomum
Fruit.Nutmeg (Semen Myristicae) is the myristic dry mature seed of Myristicaceae Myristica plant.
Piper Piperaceae, perennial evergreen liana.It is black Hu that ripe pepper fruit, which dries consequence rhicnosis contracting blackening,
Green pepper, it is referred to as white pepper after ripening fruits decortication.Pepper property heat, acrid flavour, there is warming spleen and stomach for dispelling cold, lower gas, dissolving phlegm.Pepper is containing recklessly
The compositions such as green pepper alkali, phellandrene, cloves alkene, there is deodorization, anti-corrosion and antioxidation.Bi is dialled, and fruit is containing pipering, Bi roots of grass vinegars
Amine, piperic acid and volatile oil；Seed contains sesamin；There are middle benefit gas, cold dispelling, lower gas, analgesic.
Cumin category Umbelliferae (Umbelliferae) plant cumin (Cuminumcymhmm L.) also known as cumin.It is annual
Draft, cultivated plant.Cumin is used as medicine, and is had warm stomach invigorating the spleen, is controlled the effect of lifeblood is grand.
Fennel seeds are conventional Tibetan medicine, are the drying and ripening fruit of samphire fennel (Foeniculuvulgare Mill)
It is real.Plant is tapped when ripe at the beginning of autumn fruit, is dried, lays fruit, removes impurity.Acrid flavour, it is warm-natured, have regulating qi-flowing for harmonizing stomach, control it is grand
The function of disease.Volatile ingredient is main component in fennel seeds fruit containing about 3~6%.
Carum carvi, to hide name Guo and turn round, be the fruit of samphire Caraway, its plant is perennial herb, distribution West Asia,
The ground such as Europe, China northeast, North China, Sichuan, Tibet, Europe use as carminative and spices, and China is conventional Tibetan medicine.The medicine
Warm-natured, taste micro-pungent, there is the grand disease of mediation, stomach invigorating, detoxication.Its volatile oil mainly has carvol, limonene, 5- isopropyl alkene
Base -2- methyl cyclohexanones etc..
Tibetanmedicine is thought：Three big factors in human body be present, i.e., " grand ", " red bar ", " Baconic " are main cause；Seven big materials are base
Plinth, i.e. " diet exquisiteness, blood, meat, fat, bone, marrow, essence "；Three kinds of excretas is dominate, i.e., " stool, urine, sweat ".Three is big
Factor dominates the motion change of seven big material bases and three kinds of excretas.If the balance of three big factors is destroyed, will produce
Raw various lesions.Insomnia is caused by the inclined liter of " grand ", wherein " the grand disease of the heart " is to cause the principal element of insomnia, of the invention real
Apply in example, cardamom middle benefit gas promoting the circulation of qi, press down grand disease, control insomnia；Pepper and/Bi are dialled, warming spleen and stomach for dispelling cold, stomach invigorating；Cumin, warm stomach invigorating the spleen,
Control the grand disease of lifeblood；Grand disease, the grand diseases of You Zhixin and cardiopyretic syndrome are planted by Carum carvi and fennel seeds, Zhiduo County；, in addition, coordinate dairy produce, qi-restoratives
Damage, presses down grand inclined liter, makes three big factor balances on the whole, so as to improve the sleep of body.Secondly, cardamom, pepper and/or Bi
Dial, the volatile oil active component of four kinds of cumin, fennel seeds medicinal materials containing abundant anti-insomnia, sleeping for human body can be significantly improved
Dormancy quality.
Preferably, in the present embodiment, the preparation of sleep is improved simultaneously containing nutmeg, Amomum cardamomum, cumin, fennel fruit
Perfume, Carum carvi, pepper and Bi are dialled.Though nutmeg and Amomum cardamomum are all cardamom class medicinal material, its active ingredient contained and
Its ratio is different, therefore is used cooperatively, it is possible to increase the effect of preparation.Pepper and Bi are dialled and can cooperated, and collaboration plays a role.
Further, in the present embodiment, Amomum cardamomum and myristic weight ratio are 1.2~1.5:1.What pepper and Bi were dialled
Weight ratio is 1.5~2.2:1.Under the proportioning, the effect for improving sleep is optimal.
Preferably, pepper includes black pepper and white pepper.Black pepper and white pepper essential oil antioxygenic property and removing are freely
Base ability is different.Its antioxygenic property can be improved containing black pepper and white pepper and remove the ability of free radical simultaneously.More
Preferably, the weight of black pepper and white pepper ratio is 0.8~1：0.8~1.5.Under the proportioning, the antioxygenic property of pepper and
The ability for removing free radical is optimal.
Further, preparation also includes reinforcing agent, and reinforcing agent also includes dairy produce；Preferably, dairy produce includes milk, acid
Milk and milk powder it is any.Rich in abundant mineral matter, calcium, phosphorus, iron, zinc, copper, manganese, molybdenum in dairy produce.It is the optimal of human calcium
Source, and calcium phosphorus ration is very appropriate, beneficial to the absorption of calcium.Damaged with qi-restoratives, beneficial lung stomach, improve the effect of sleep.
Present invention also offers the preparation method of above-mentioned preparation, and the first is to be mixed to get raw material.In this implementation
In example, the mixed operation of raw material is had it is a variety of, such as starting material with water extracted, is concentrated, dry after system is mixed with pharmaceutic adjuvant
Into granule, capsule and tablet etc..Preferably, raw material is mixed into extraction with dairy produce, the active ingredient of raw material can be made
Sufficiently in dissolving and dairy produce, while also allow for patient and take.It should be noted that the improvement sleep that the present embodiment provides
The formulation of preparation is unlimited, or liquid or semisolid preparation.
Another preparation method of preparation is additionally provided, the first raw material is used into supercritical CO2Be obtained by extraction volatile oil and
The dregs of a decoction, wherein, extracting pressure 25MPa~30MPa, 40~60 DEG C of extraction temperature, CO26~10kg/h of flow, extraction time 60~
120min；Medicinal extract is made in the extraction of dregs of a decoction ethanol, by volatile oil, medicinal extract and pharmaceutic adjuvant mixing granulation.It is rich in and waves in preparation
Hair oil, but volatile oil is readily volatilized, so as to weaken drug effect.Therefore using in supercritical carbon dioxide extraction method extraction preparation
Volatile oil can significantly improve efficiency.Found by inventor is creative, the preparation obtained under the conditions of above-mentioned parameter, volatilization
Oil extract rate highest, the drug effect of preparation are optimal.After obtaining the first component, coordinate reinforcing agent use.
Further, in present pre-ferred embodiments, when extracting the dregs of a decoction, with 4~10 times that weight is the dregs of a decoction, and concentration
For 50%~95% ethanol, at 45~70 DEG C, 30min~90min is extracted.The dregs of a decoction are extracted again using ethanol, are rationally utilized
The dregs of a decoction, improve the drug effect of preparation.It is emphasized that the present embodiment is extracted using ethanol, with directly using water extraction
Take and compare, more active ingredients can be obtained.
In the present embodiment, in order that the composition of volatile oil is more stable in obtained preparation, by volatile oil mixing granulation
Before, in addition to：Volatile oil is included with beta-schardinger dextrin.Preferably, pasted with 1.8~5 times of β-ring of volatilization weight of oil
Essence includes 30~90min at 38~48 DEG C.
Preferably, after obtaining volatile oil, before granulation, including：Dairy produce, volatile oil, medicinal extract and pharmaceutic adjuvant are mixed
Close granulation.In other words, directly by dairy produce and other raw material mixing granulations.Further facilitate patient's use.Need to illustrate
, now dairy produce is milk powder.If dairy produce is liquid, during such as milk, can be spray-dried after milk cold sterilization, system
Into milk powder.
The preparation method of preparation is simple, rationally make use of raw material, farthest extracts and retains volatile ingredient, ensures
The stability of preparation；Simultaneously said preparation carry take convenient, dosage with it is quality controllable.
The feature and performance of the present invention are described in further detail with reference to embodiments.
Embodiment 1
A kind of preparation for improving sleep is present embodiments provided, raw material includes：The Amomum cardamomum of 20 parts by weight, 10 parts by weight
Pepper (including weight ratio is 0.8:1.5 black pepper and white pepper), the fennel seeds of 20 parts by weight.
The preparation method of the preparation of above-mentioned improvement sleep is present embodiments provided, it includes：Raw material is mixed.
Embodiment 2
A kind of preparation for improving sleep is present embodiments provided, raw material includes：The Amomum cardamomum of 35 parts by weight, 25 parts by weight
Pepper (including weight ratio is 1:1 black pepper and white pepper), the fennel seeds of 40 parts by weight and cumin.Reinforcing agent includes 300
The milk of parts by weight.
The preparation method of the preparation of above-mentioned improvement sleep is present embodiments provided, it includes：Raw material is extracted with milk, mistake
Filter the dregs of a decoction.
Embodiment 3
A kind of preparation for improving sleep is present embodiments provided, raw material includes：The nutmeg of 30 parts by weight, 20 parts by weight
Pepper (including weight ratio is 1:1.5 black pepper and white pepper), the fennel seeds of 30 parts by weight.Reinforcing agent includes 220 parts of yak
Milk.
The preparation method of the preparation of above-mentioned improvement sleep is present embodiments provided, it includes：
S1：Raw material is used into supercritical CO2Volatile oil and the dregs of a decoction is obtained by extraction, wherein, extracting pressure 30MPa, extraction temperature
Spend 50 DEG C, CO2Flow 8kg/h, extraction time 100min obtain volatile oil.
S2：With 3 times of beta-schardinger dextrin of volatilization weight of oil 60min is included at 42 DEG C.
S3：By 6 times that dregs of a decoction use is the dregs of a decoction, and concentration is 90% ethanol, and at 60 DEG C, leaching is made after extracting 60min
Cream.
S4：After yak milk cold sterilization, spray drying, yak milk powder is made.
S5：By the volatile oil after inclusion, medicinal extract, yak milk powder and pharmaceutic adjuvant mixing granulation.
Embodiment 4
A kind of preparation for improving sleep is present embodiments provided, raw material includes：The nutmeg of 22 parts by weight, 16 parts by weight
Black pepper, the Carum carvi of 25 parts by weight.Reinforcing agent includes the milk of 200 parts by weight.
The preparation method of the preparation of above-mentioned improvement sleep is present embodiments provided, it includes：Raw material is used into supercritical CO2
Volatile oil and the dregs of a decoction is obtained by extraction, wherein, extracting pressure 25MPa, 40 DEG C of extraction temperature, CO2Flow 6kg/h, extraction time
60min obtains volatile oil, and 30min is included at 40 DEG C with 1.8 times of beta-schardinger dextrin of volatilization weight of oil.By the dregs of a decoction with for the dregs of a decoction
5 times, and concentration be 50% ethanol, at 45 DEG C, extract 30min after medicinal extract is made, by the volatile oil after inclusion, medicinal extract with
Pharmaceutic adjuvant mixing granulation.
Embodiment 5
A kind of preparation for improving sleep is present embodiments provided, raw material includes：The nutmeg of 32 parts by weight, 22 parts by weight
White pepper, the fennel seeds of 33 parts by weight.Reinforcing agent includes 40 parts of milk powder.
The preparation method of the preparation of above-mentioned improvement sleep is present embodiments provided, it includes：Raw material is used into supercritical CO2
Volatile oil and the dregs of a decoction is obtained by extraction, wherein, extracting pressure 30MPa, 60 DEG C of extraction temperature, CO2Flow 10kg/h, extraction time
120min obtains volatile oil, and 90min is included at 38 DEG C with 4 times of beta-schardinger dextrin of volatilization weight of oil.By the dregs of a decoction with for the dregs of a decoction
10 times, and concentration be 95% ethanol, at 70 DEG C, extract 90min after medicinal extract is made, by the volatile oil after inclusion, medicinal extract,
Milk powder and pharmaceutic adjuvant mixing granulation.
Embodiment 6
A kind of preparation for improving sleep is present embodiments provided, raw material includes：(including weight ratio is the cardamom of 30 parts by weight
1.3:1 nutmeg and Amomum cardamomum), the pepper of 20 parts by weight and Bi dial that (the weight ratio that pepper and Bi are dialled is 2:1), 30 parts by weight
Fennel seeds.Reinforcing agent includes 220 parts of yak milk.
The preparation method of the preparation of above-mentioned improvement sleep is present embodiments provided, it includes：Raw material is used into supercritical CO2
Volatile oil and the dregs of a decoction is obtained by extraction, wherein, extracting pressure 30MPa, 50 DEG C of extraction temperature, CO2Flow 8kg/h, extraction time
100min obtains volatile oil.With 3 times of beta-schardinger dextrin of volatilization weight of oil 60min is included at 42 DEG C.By the dregs of a decoction with for the dregs of a decoction
6 times, and concentration be 90% ethanol, at 60 DEG C, extract 60min after medicinal extract is made.After yak milk cold sterilization, spraying
Dry, yak milk powder is made.By the volatile oil after inclusion, medicinal extract, yak milk powder and pharmaceutic adjuvant mixing granulation.
Embodiment 7
A kind of preparation for improving sleep is present embodiments provided, raw material includes：(including weight ratio is the cardamom of 30 parts by weight
1.3:1 nutmeg and Amomum cardamomum), the Bi of 20 parts by weight is dialled, the Carum carvi of 30 parts by weight.Reinforcing agent includes 220 parts of yak
Milk.
The preparation method of the preparation of above-mentioned improvement sleep is present embodiments provided, it includes：Raw material is used into supercritical CO2
Volatile oil and the dregs of a decoction is obtained by extraction, wherein, extracting pressure 30MPa, 50 DEG C of extraction temperature, CO2Flow 8kg/h, extraction time
100min obtains volatile oil.With 3 times of beta-schardinger dextrin of volatilization weight of oil 60min is included at 42 DEG C.By the dregs of a decoction with for the dregs of a decoction
6 times, and concentration be 90% ethanol, at 60 DEG C, extract 60min after medicinal extract is made.After yak milk cold sterilization, spraying
Dry, yak milk powder is made.By the volatile oil after inclusion, medicinal extract, yak milk powder and pharmaceutic adjuvant mixing granulation.
Comparative example 1
This comparative example provides a kind of preparation for improving sleep, and its raw material includes：The Amomum cardamomum of 32 parts by weight, 22 parts by weight
Bi dial, the cumin of 24 parts by weight.
The volatile oil oil yield of test example 1
Experiment packet and method：
Test group 1：For the method with when extraction volatile oil of raw material in embodiment 3；
Test group 2：For the method with when extraction volatile oil of raw material in embodiment 4；
Test group 3：For the method with when extraction volatile oil of raw material in embodiment 5；
Control group：The raw material provided with conventional steam distillation extraction embodiment 3.
Then oil yield is calculated；The quality of oil yield=volatile oil/raw material gross mass × 100%.
The oil yield of table 1 compares
It can be seen from table 1, compared with control group is using steam distillation, test group 1~3 uses supercritical carbon dioxide
The oil yield of abstraction technique is higher, and the content of volatile oil for illustrating to obtain is more.
The clinical test of test example 2
1st, case is selected in
120 patients are chosen, are divided into 6 groups, (the system provided respectively using embodiment 1~5 and comparative example 1 of test group 1~6
Agent, note：Cooperation dairy produce use without dairy produce).
Its inclusion criteria is formulated with reference to the State Administration of Traditional Chinese Medicines《Chinese medical disease Standardization of diagnosis and curative effect》：The difficulty 1. the lighter people sleeps
Or sleep and easily wake up, it is insomnia after waking up, continuous more than 3 weeks, severe one was lain awake all night；2. be often accompanied by headache and dizziness, palpitation and amnesia, god it is tired
Power, have no peace of mind, dreaminess etc.；3. through each system laboratory inspection, other nypnapagogic organic diseases are found no.
2nd, efficacy assessment standard
What the State Administration of Traditional Chinese Medicines formulated《Chinese medical disease Standardization of diagnosis and curative effect》：
1. cure：After 2 courses for the treatment of of acupuncture, sleep is normal, and simultaneous phenomenon disappears, and follow-up one month is without recurrence；
2. take a turn for the better：After treating 2 courses for the treatment of, the length of one's sleep extends, and simultaneous phenomenon improves；
3. take effect：Patient mental's situation and simultaneous phenomenon have improvement；
It is 4. invalid：Symptom is without change.
3rd, result and analysis
The clinical effectiveness of table 2 (example)
It can be seen from table 2, compared with comparative example 1, the patient numbers of the healing for the preparation that embodiment 1~7 provides are more, invalid
It is less, illustrate embodiment 1~7 preparation improve sleep effect it is notable.Wherein, directly raw material is mixed with Examples 1 and 2
Or compared with milk extraction, the preparation of embodiment 3~7 all employs supercritical carbon dioxide extraction method and has extracted waving for raw material
Hair oil, therefore curative effect is preferable.Secondly, compared with Example 1, embodiment 2 is to extract the first raw material with milk, therefore embodiment
2 the effect of, is good.Compared with embodiment 4 and 5, the pepper in embodiment 3 contains white pepper and black pepper, therefore embodiment 3 provides
Preparation the effect of it is good.Compared with Example 3, embodiment 6 contains Amomum cardamomum and nutmeg simultaneously, therefore pepper and Bi, which are dialled, to be implemented
The effect of example 6, is optimal.
To sum up, the effect of the improvement sleep of preparation provided by the invention is good, easy to use, the reasonable science of its preparation method,
The preparation curative effect prepared is good.
Embodiments described above is part of the embodiment of the present invention, rather than whole embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. a kind of preparation for improving sleep, it is characterised in that the raw material of the preparation includes：
The cardamom of 20~35 parts by weight, the cardamom include one or both of Amomum cardamomum and nutmeg；
The pepper of 10~25 parts by weight and/or Bi are dialled, and the pepper includes at least one of black pepper and white pepper；
At least one of the fennel seeds of 20~40 parts by weight, Carum carvi, cumin.
2. the preparation according to claim 1 for improving sleep, it is characterised in that the raw material includes 22~32 parts by weight
The cardamom, the pepper of 16~22 parts by weight, the fennel seeds of 25~33 parts by weight, the Carum carvi, the cumin
At least one of celery.
3. the preparation according to claim 2 for improving sleep, it is characterised in that the black pepper and the white pepper weight
Than for 0.8~1：0.8~1.5.
4. the preparation according to claim 1 for improving sleep, it is characterised in that the preparation also includes reinforcing agent, described
Reinforcing agent includes dairy produce；Preferably, the dairy produce includes any of milk, Yoghourt and milk powder.
5. a kind of preparation method of the preparation as claimed in claim 1 for improving sleep, it is characterised in that it includes：By described in
Raw material mixes.
6. the preparation method of the preparation according to claim 5 for improving sleep, it is characterised in that by the raw material dairy
Product extract.
7. a kind of preparation method of the preparation as claimed in claim 1 for improving sleep, it is characterised in that use the raw material
Supercritical CO2Volatile oil and the dregs of a decoction is obtained by extraction, wherein, extracting pressure 25MPa~30MPa, 40~60 DEG C of extraction temperature, CO2Stream
Measure 6~10kg/h, 60~120min of extraction time；Medicinal extract is made in dregs of a decoction ethanol extraction, by the volatile oil, described
Medicinal extract and pharmaceutic adjuvant mixing granulation.
8. the preparation method of the preparation according to claim 7 for improving sleep, it is characterised in that when extracting the dregs of a decoction,
4~10 times with weight for the dregs of a decoction, and concentration is 50%~95% ethanol, at 45~70 DEG C, extracts 30min
~90min.
9. the preparation method of the preparation according to claim 7 for improving sleep, it is characterised in that mix the volatile oil
Before granulation, in addition to：30 are included at 38~48 DEG C with 1.8~5 times of beta-schardinger dextrin of the volatilization weight of oil~
90min。
10. the preparation method of the preparation according to claim 7 for improving sleep, it is characterised in that by the volatile oil, institute
State medicinal extract, milk powder and the pharmaceutic adjuvant mixing granulation.
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| CN109463760A (en) * | 2018-12-26 | 2019-03-15 | 青海民族大学 | A kind of preparing process improving sleep quality health care product |
| CN111569038A (en) * | 2020-06-15 | 2020-08-25 | 西藏奇正藏药股份有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
| CN114794239A (en) * | 2022-03-25 | 2022-07-29 | 山南市藏医医院 | Sleep-aiding composition and preparation method and application thereof |
| CN115137075A (en) * | 2022-06-27 | 2022-10-04 | 王民珏 | Sleep-aiding food for increasing endogenous melatonin and application thereof |
| CN115475220A (en) * | 2022-10-19 | 2022-12-16 | 西藏藏医药大学附属医院 | Three-flavor cardamom soup powder and preparation process thereof |
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Application publication date: 20171121 |