CN107184662A - A kind of composition for improving sleep and preparation method thereof - Google Patents
A kind of composition for improving sleep and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/235—Foeniculum (fennel)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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Abstract
A kind of composition for improving sleep and preparation method thereof, is related to pharmaceutical technology field.Composition, is made up of raw material, and raw material includes at least one of 20~35 parts by weight nutmegs, the pepper of 10~25 parts by weight, the fennel seeds of 20~40 parts by weight, Carum carvi, cumin.The effect that said composition improves sleep is good.The preparation method of composition, it includes：Raw material is obtained into volatile oil and the dregs of a decoction using supercritical extract, wherein, extracting pressure 25MPa~30MPa, 40~60 DEG C of extraction temperature, CO26~10kg/h of flow, 60~120min of extraction time；Dregs of a decoction ethanol is extracted medicinal extract is made, by volatile oil, medicinal extract and pharmaceutic adjuvant mixing granulation.The preparation method is simple, and the curative effect of the composition prepared is good.
Description
Technical field
The present invention relates to pharmaceutical technology field, and more particularly to a kind of composition for improving sleep and preparation method thereof.
Background technology
With work, the quickening of rhythm of life, the life of people, operating pressure increasingly increase.Thus caused insomnia, suppression
Strongly fragrant the problems such as, turns into the significant problem for seriously endangering human health.According to the investigation of the World Health Organization, about 27% people, sleep
In the presence of it is different degrees of the problem of.CSRS in 2003 is up to national 40,000 parts of questionnaire statistical result showeds
The insomnia of 38.2% Chinese Urban Residents various degrees, higher than the ratio in the world 27%.
The medicine of Modern medical therapy insomnia mainly has benzodiazepine and Non-benzodiazepine medicine, and other
Medicine (including anxiolytic drugs, antidepressant, epiphysin and hormone medicine) conduced to sleep etc..Said medicine is universal
With strong, the easy habituation of drug dependence, it is also easy to produce the defects such as drug resistance.The patient of long-term taking once be discontinued occur look forward or upwards it is absurd,
Epilepsy seizure, tremble, perspire and appetite be deteriorated etc. symptom, therefore, market in urgent need is without pharmacological dependence, safe and reliable and sleeping
The obvious health products of effect.
The content of the invention
Improve the composition of sleep it is an object of the invention to provide a kind of, said composition has the effect for improving sleep.
Another object of the present invention is to provide a kind of preparation method for the composition for improving sleep, preparation method letter
It is single, raw material is taken full advantage of, the curative effect of the composition prepared is good.
The present invention is solved its technical problem and realized using following technical scheme.
The present invention proposes a kind of composition for improving and sleeping, and is made up of raw material, and raw material includes 20~35 parts by weight nutmegs,
At least one of the pepper of 10~25 parts by weight, the fennel seeds of 20~40 parts by weight, Carum carvi, cumin.
The present invention proposes a kind of preparation method for the composition for improving sleep, and it includes：Raw material is mixed.
The present invention proposes a kind of preparation method for the composition for improving sleep, and it includes：Raw material is used into supercritical extract
Volatile oil and the dregs of a decoction are obtained, wherein, extracting pressure 25MPa~30MPa, 40~60 DEG C of extraction temperature, CO26~10kg/h of flow,
60~120min of extraction time；Dregs of a decoction ethanol is extracted medicinal extract is made, by volatile oil, medicinal extract and pharmaceutic adjuvant mixing granulation.
A kind of beneficial effect of composition and preparation method thereof for improving sleep proposed by the present invention is：
It is a kind of to improve the composition of sleep, including nutmeg, pepper, cumin containing abundant volatile oil active component
Celery, fennel seeds.Wherein, nutmeg contains methylisoeugenol；Main effective medicinal components in pepper are alkaloid, volatile oil
And amide-type etc.；The compound contained in cumin essential oil is mainly monoterpene, sequiterpene, aromatic aldehyde, ketone, ether material；It is small
Fennel contains 3~6% volatile oil component.These volatile oil of modern pharmacological research are the main components of anti-insomnia.Secondly, Tibetanmedicine
Think, cardamom middle benefit gas promoting the circulation of qi, press down grand disease, control insomnia；Pepper, warming spleen and stomach for dispelling cold, stomach invigorating；Cumin, warm stomach invigorating the spleen, to control lifeblood grand
Disease；Carum carvi and fennel seeds, control a variety of grand diseases, the grand diseases of You Zhixin and cardiopyretic syndrome, regulating qi-flowing for harmonizing stomach；On the whole put down three big factors
Weighing apparatus, so as to improve the sleep of body.
Again, the reasonable mixture ratio between the raw material of said composition, can play the synergy of maximum under the proportioning；Together
When due to said composition formula it is simple, only four taste raw materials, therefore said composition has no toxic side effect, patient does not allow to be also easy to produce dependence
Property.
The preparation method of above-mentioned composition, simply, rationally make use of raw material, farthest extract and retain volatility into
Point, it is ensured that the stability of composition；Simultaneously said composition carry take convenient, dosage with it is quality controllable.
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical scheme be clearly and completely described.Unreceipted actual conditions person, builds according to normal condition or manufacturer in embodiment
The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, are the conventional production that can be obtained by commercially available purchase
Product.
Composition of a kind of improvement sleep of the embodiment of the present invention and preparation method thereof is specifically described below.
A kind of composition of improvement sleep provided in an embodiment of the present invention, is made up, raw material includes 20~35 weight of raw material
Part nutmeg, the pepper of 10~25 parts by weight, at least one of the fennel seeds of 20~40 parts by weight, Carum carvi, cumin.
Preferably, raw material include 22~32 parts by weight nutmegs, the pepper of 16~22 parts by weight, 16~24 parts by weight it is diligent
At least one of right celery, the fennel seeds of 25~33 parts by weight, Carum carvi, cumin.
Preferably, raw material includes 30 parts by weight nutmegs, the pepper of 20 parts by weight, the fennel seeds of 30 parts by weight, Carum carvi,
At least one of cumin.
Nutmeg (Myristica fragrans), is Myristica aiphyllium plant.Stop with middle benefit gas promoting the circulation of qi, puckery intestines
Contain methylisoeugenol in the effect of rushing down, nutmeg, methylisoeugenol, which has, suppresses nervous centralis, and strengthens amobarbital
Soporific function.
Piper Piperaceae, perennial evergreen liana.Ripe pepper fruit dries consequence rhicnosis contracting blackening for black Hu
Green pepper, is referred to as white pepper after ripening fruits decortication.Pepper property heat, it is pungent, there are warming spleen and stomach for dispelling cold, lower gas, dissolving phlegm.Pepper is containing recklessly
The compositions such as green pepper alkali, phellandrene, cloves alkene, with deodorization, anti-corrosion and antioxidation.
Cumin belongs to Umbelliferae (Umbelliferae) plant cumin (Cuminumcymhmm L.) also known as cumin.It is annual
Draft, cultivated plant.Cumin is used as medicine, and with warm stomach invigorating the spleen, controls the grand sick effect of lifeblood.
Fennel seeds are conventional Tibetan medicine, are the drying and ripening fruit of samphire fennel (Foeniculuvulgare Mill)
It is real.Plant is tapped when ripe at the beginning of autumn fruit, is dried, fruit is laid, impurity is removed.It is pungent, it is warm-natured, with regulating qi-flowing for harmonizing stomach, control grand
The function of disease.Volatile ingredient is main component in fennel seeds fruit containing about 3~6%.
Carum carvi, hides name Guo and turns round, and is the fruit of samphire Caraway, and its plant is perennial herb, distribution West Asia,
The ground such as Europe, China northeast, North China, Sichuan, Tibet, Europe is used as carminative and spices, and China is conventional Tibetan medicine.The medicine
Warm-natured, taste micro-pungent, with the grand disease of mediation, stomach invigorating, detoxication.Effect.Its volatile oil mainly has carvol, limonene, 5- different
Acrylic -2- methyl cyclohexanones etc..
Tibetanmedicine is thought：Presence three big factors, i.e. " grand ", " red bar ", " Baconic " are main cause in human body；Seven big materials are base
Plinth, i.e. " diet exquisiteness, blood, meat, fat, bone, marrow, essence "；Three kinds of excretas is dominate, i.e., " stool, urine, sweat ".Three is big
Factor dominates the motion change of seven big material bases and three kinds of excretas.If the balance of three big factors is destroyed, it will produce
Raw various lesions.Insomnia is caused by the inclined liter of " grand ", wherein " the grand disease of the heart " is to cause the principal element of insomnia, of the invention real
Apply in example, Tibetanmedicine is thought, cardamom middle benefit gas promoting the circulation of qi, press down grand disease, control insomnia；Pepper, warming spleen and stomach for dispelling cold, stomach invigorating；Cumin, warm stomach is good for
The grand disease of lifeblood is controlled in spleen, dissipating bind water；Carum carvi and fennel seeds, control a variety of grand diseases, the grand diseases of You Zhixin and cardiopyretic syndrome, regulating qi-flowing for harmonizing stomach；
In addition dairy produce is used cooperatively, qi-restoratives is damaged, and presses down grand inclined liter, three big factor balances is made on the whole, so as to improve sleeping for body
Sleep.
Secondly, nutmeg, pepper, cumin, fennel seeds, Carum carvi are containing abundant volatile oil active component.Pork and beans
It is cool to contain methylisoeugenol；Main effective medicinal components in pepper are alkaloid, volatile oil and amide-type etc.；Cumin essence
The compound contained in oil is mainly monoterpene, sequiterpene, aromatic aldehyde, ketone, ether material；Fennel seeds contain 3~6% volatile oil
Composition.Modern pharmacological research proves that these volatile oil are the main components of anti-insomnia.
Preferably, pepper includes black pepper and white pepper.Black pepper and white pepper essential oil antioxygenic property and removing are freely
Base ability is different.Its antioxygenic property can be improved containing black pepper and white pepper and remove the ability of free radical simultaneously.More
Preferably, the weight ratio of black pepper and white pepper is 0.8~1：0.8~1.5.Under the proportioning, the antioxygenic property of pepper and
The ability for removing free radical is optimal.
Present invention also offers the preparation method of above-mentioned composition, the first is to mix raw material, it is preferable that by raw material powder
The powder of composition is mixed and made into after broken.In the present embodiment, obtaining the method for composition has a variety of, such as carries starting material with water
Take, concentrate, dry after be mixed and made into granule, capsule and tablet etc. with pharmaceutic adjuvant.It should be noted that the present embodiment
The formulation of the preparation of the improvement sleep of offer is not limited, or liquid or semisolid preparation.
Another preparation method of composition is additionally provided, raw material is obtained into volatile oil and the dregs of a decoction using supercritical extract,
Wherein, extracting pressure 25MPa~30MPa, 40~60 DEG C of extraction temperature, CO26~10kg/h of flow, extraction time 60~
120min；Dregs of a decoction ethanol is extracted medicinal extract is made, by volatile oil, medicinal extract and pharmaceutic adjuvant mixing granulation.It is rich in composition
Volatile oil, but volatile oil is readily volatilized, so as to weaken drug effect.Therefore combination is extracted using supercritical carbon dioxide extraction method
Volatile oil in thing can significantly improve efficiency.Found by inventor's creativeness, the combination obtained under the conditions of above-mentioned parameter
Thing, volatile oil oil yield highest, the drug effect of composition is optimal.
Further, in present pre-ferred embodiments, when extracting the dregs of a decoction, with 4~10 times that weight is the dregs of a decoction, and concentration
For 50%~95% ethanol, at 45~70 DEG C, 30min~90min is extracted.The dregs of a decoction are extracted again using ethanol, are rationally utilized
The dregs of a decoction, improve the drug effect of composition.It is emphasized that the present embodiment is extracted using ethanol, with directly using water
Extraction is compared, and can obtain more active ingredients.
In the present embodiment, in order that the composition of volatile oil is more stablized in obtained composition, volatile oil is mixed and made
Before grain, in addition to：Volatile oil is included with beta-schardinger dextrin.Preferably, with 1.8~5 times of β-ring of volatilization weight of oil
Dextrin includes 30~90min at 38~48 DEG C.
The preparation method of composition is simple, rationally make use of raw material, farthest extracts and retain volatile ingredient, protects
The stability of composition is demonstrate,proved；Simultaneously said composition carry take convenient, dosage with it is quality controllable.
In addition, during using composition, preferably coordinating milk to be used together, milk can aid in improving sleep quality.
The feature and performance to the present invention are described in further detail with reference to embodiments.
Embodiment 1
A kind of composition for improving and sleeping is present embodiments provided, its raw material includes：The nutmeg of 20 parts by weight, 10 weight
Part pepper (including weight ratio be 0.8:1.5 black pepper and white pepper), the fennel seeds of 20 parts by weight.
The preparation method of the composition of above-mentioned improvement sleep is present embodiments provided, it includes：Raw material is mixed.
Embodiment 2
A kind of composition for improving and sleeping is present embodiments provided, its raw material includes：The nutmeg of 35 parts by weight, 25 weight
Part pepper (including weight ratio be 1:1 black pepper and white pepper), the fennel seeds of 40 parts by weight and cumin.
The preparation method of the composition of above-mentioned improvement sleep is present embodiments provided, it includes：By raw material using overcritical
Volatile oil and the dregs of a decoction is obtained by extraction, wherein, extracting pressure 28MPa, 40~60 DEG C of extraction temperature, CO2Flow 7kg/h, during extraction
Between 80min；By 5 times that dregs of a decoction use is the dregs of a decoction, and concentration is 80% ethanol, and at 55 DEG C, medicinal extract is made after extracting 45min,
By volatile oil, medicinal extract and pharmaceutic adjuvant mixing granulation.
Embodiment 3
A kind of composition for improving and sleeping is present embodiments provided, its raw material includes：The nutmeg of 30 parts by weight, 20 weight
Part pepper (including weight ratio be 1:1.5 black pepper and white pepper), the fennel seeds of 30 parts by weight.
The preparation method of the composition of above-mentioned improvement sleep is present embodiments provided, it includes：
S1：Raw material is obtained into volatile oil and the dregs of a decoction using supercritical extract, wherein, extracting pressure 30MPa, extraction temperature 50
℃、CO2Flow 8kg/h, extraction time 100min obtains volatile oil.
S2：With 3 times of beta-schardinger dextrin of volatilization weight of oil 60min is included at 42 DEG C.
S3：By 6 times that dregs of a decoction use is the dregs of a decoction, and concentration is 90% ethanol, and at 60 DEG C, leaching is made after extracting 60min
Cream.
S4：By the volatile oil after inclusion, medicinal extract and pharmaceutic adjuvant mixing granulation.
Embodiment 4
A kind of composition for improving and sleeping is present embodiments provided, its raw material includes：The nutmeg of 22 parts by weight, 16 weight
The black pepper of part, the Carum carvi of 25 parts by weight.
The preparation method of the composition of above-mentioned improvement sleep is present embodiments provided, it includes：By raw material using overcritical
Volatile oil and the dregs of a decoction is obtained by extraction, wherein, extracting pressure 25MPa, 40 DEG C of extraction temperature, CO2Flow 6kg/h, extraction time
60min obtains volatile oil, and 30min is included at 40 DEG C with 1.8 times of beta-schardinger dextrin of volatilization weight of oil.By the dregs of a decoction with for the dregs of a decoction
4 times, and concentration be 50% ethanol, at 48 DEG C, extract 30min after medicinal extract is made, by the volatile oil after inclusion, medicinal extract with
Pharmaceutic adjuvant mixing granulation.
Embodiment 5
A kind of composition for improving and sleeping is present embodiments provided, its raw material includes：The nutmeg of 32 parts by weight, 22 weight
The white pepper of part, the cumin of 33 parts by weight.
The preparation method of the composition of above-mentioned improvement sleep is present embodiments provided, it includes：By raw material using overcritical
Volatile oil and the dregs of a decoction is obtained by extraction, wherein, extracting pressure 30MPa, 60 DEG C of extraction temperature, CO2Flow 10kg/h, extraction time
120min obtains volatile oil, and 90min is included at 38 DEG C with 5 times of beta-schardinger dextrin of volatilization weight of oil.By the dregs of a decoction with for the dregs of a decoction
10 times, and concentration be 95% ethanol, at 70 DEG C, extract 90min after medicinal extract is made, by the volatile oil after inclusion, medicinal extract
With pharmaceutic adjuvant mixing granulation.
Comparative example 1
This comparative example provides a kind of composition for improving and sleeping, and its raw material includes：The Amomum cardamomum of 32 parts by weight, 22 weight
The Bi of part is dialled, the cumin of 24 parts by weight.
This comparative example provides the preparation method for the composition that above-mentioned improvement is slept, and it includes：Raw material is mixed.
The volatile oil oil yield of test example 1
Experiment packet and method：
Test group 1：For the method with when extraction volatile oil of raw material in embodiment 3；
Test group 2：For the method with when extraction volatile oil of raw material in embodiment 4；
Test group 3：For the method with when extraction volatile oil of raw material in embodiment 5；
Control group：The raw material that embodiment 3 is provided is extracted with conventional steam distillation.
Then oil yield is calculated；The quality of oil yield=volatile oil/raw material gross mass × 100%.
The oil yield of table 1 compares
It can be seen from table 1, compared with control group is using steam distillation, test group 1~3 uses supercritical carbon dioxide
The oil yield of abstraction technique is higher, illustrates that the obtained content of volatile oil is more.
The clinical test of test example 2
1st, case is selected in
120 patients are chosen, 6 groups, (group provided respectively using embodiment 1~5 and comparative example 1 of test group 1~6 are provided
Compound) three times a day, a certain amount of milk is taken again before sleeping.
Its inclusion criteria is formulated with reference to the State Administration of Traditional Chinese Medicines《Chinese medical disease Standardization of diagnosis and curative effect》：1. the lighter people sleeps difficulty
Or sleep and easily wake up, it is insomnia after waking up, continuous more than 3 weeks, severe one was lain awake all night；2. be often accompanied by headache and dizziness, palpitation and amnesia, god it is tired
Power, have no peace of mind, dreaminess etc.；3. through each system laboratory inspection, other nypnapagogic organic diseases are found no.
2nd, efficacy assessment standard
What the State Administration of Traditional Chinese Medicines formulated《Chinese medical disease Standardization of diagnosis and curative effect》：
1. cure：After 2 courses for the treatment of of acupuncture, sleep is normal, and simultaneous phenomenon disappears, and follow-up one month is without recurrence；
2. take a turn for the better：Treat after 2 courses for the treatment of, length of one's sleep extension, simultaneous phenomenon improves；
3. take effect：Patient mental's situation and simultaneous phenomenon have improvement；
4. it is invalid：Symptom is without change.
3rd, result and analysis
The clinical effectiveness of table 2 (example)
It can be seen from table 2, compared with comparative example 1, the patient numbers of the healing for the composition that embodiment 1~5 is provided are more, nothing
What is imitated is less, illustrates that the effect of the composition for improved sleep of embodiment 1~5 is notable.Wherein, directly raw material is mixed with embodiment 1
Conjunction is compared, and the composition of embodiment 2~5 all employs the volatile oil that supercritical carbon dioxide extraction method has extracted raw material, because
This curative effect is preferable.Secondly, compared with Example 2, embodiment 3 is included volatile oil, compared with embodiment 4 and 5, is implemented
Pepper in example 3 contains white pepper and black pepper, therefore the curative effect of the composition of the offer of embodiment 3 is optimal.
To sum up, the effect of the improvement sleep for the composition that the present invention is provided is good, and the reasonable science of its preparation method is prepared
Composition curative effect it is good.
Embodiments described above is a part of embodiment of the invention, rather than whole embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. a kind of improve the composition of sleep, it is characterised in that is made up of raw material, the raw material includes the meat of 20~35 parts by weight
At least one of cardamom, the pepper of 10~25 parts by weight, the fennel seeds of 20~40 parts by weight, Carum carvi, cumin.
2. according to claim 1 improve the composition of sleep, it is characterised in that the raw material includes 22~32 parts by weight
The nutmeg, the pepper of 16~22 parts by weight is the fennel seeds of 25~33 parts by weight, the Carum carvi, described
At least one of cumin.
3. according to claim 1 improve the composition of sleep, it is characterised in that the raw material includes the institute of 30 parts by weight
State nutmeg, the pepper of 20 parts by weight, in the fennel seeds of 30 parts by weight, the Carum carvi, the cumin extremely
Few one kind.
4. according to claim 1 improve the composition of sleep, it is characterised in that the pepper includes black pepper and Bai Hu
Green pepper.
5. according to claim 4 improve the composition of sleep, it is characterised in that the black pepper and the white pepper
Weight ratio is 0.8~1：0.8~1.5.
6. a kind of preparation method of the composition as claimed in claim 1 for improving sleep, it is characterised in that mix the raw material
Close.
7. a kind of preparation method of the composition as claimed in claim 1 for improving sleep, it is characterised in that use the raw material
Supercritical extract obtains volatile oil and the dregs of a decoction, wherein, extracting pressure 25MPa~30MPa, 40~60 DEG C of extraction temperature, CO2Flow
6~10kg/h, 60~120min of extraction time；The dregs of a decoction ethanol is extracted medicinal extract is made, by the volatile oil, the leaching
Cream and pharmaceutic adjuvant mixing granulation.
8. the preparation method of the composition according to claim 7 for improving sleep, it is characterised in that extract the dregs of a decoction
When, it is 4~10 times of the dregs of a decoction with weight, and concentration is 50%~95% ethanol, at 45~70 DEG C, is extracted
30min~90min.
9. the preparation method of the composition of the improvement sleep according to claim 7 or 8, it is characterised in that by the volatilization
Before oily mixing granulation, in addition to：The volatile oil is included with beta-schardinger dextrin.
10. the preparation method of the composition according to claim 9 for improving sleep, it is characterised in that use the volatile oil
1.8~5 times of the beta-schardinger dextrin of weight includes 30~90min at 38~48 DEG C.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111569038A (en) * | 2020-06-15 | 2020-08-25 | 西藏奇正藏药股份有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN1483430A (en) * | 2002-09-19 | 2004-03-24 | 中国科学院西北高原生物研究所 | Health care medicinal composition for improving sleeping and preparation preocess thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111569038A (en) * | 2020-06-15 | 2020-08-25 | 西藏奇正藏药股份有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
| CN111569038B (en) * | 2020-06-15 | 2022-04-26 | 西藏奇正藏药股份有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
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Application publication date: 20170922 |