CN107362225A - A kind of cordate houttuynia essence combination - Google Patents
A kind of cordate houttuynia essence combination Download PDFInfo
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- CN107362225A CN107362225A CN201710722628.6A CN201710722628A CN107362225A CN 107362225 A CN107362225 A CN 107362225A CN 201710722628 A CN201710722628 A CN 201710722628A CN 107362225 A CN107362225 A CN 107362225A
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- Prior art keywords
- extract
- cordate houttuynia
- essence
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- houttuynia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/76—Salicaceae (Willow family), e.g. poplar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
Abstract
The invention discloses a kind of cordate houttuynia essence combination, and in terms of parts by weight, the composition includes following component：20-30 parts of cordate houttuynia essence, 10-20 parts of saw palmetto oil, 20-50 parts of poplar flower extract, 5-10 parts of Fructus Bruceae extract, the Fructus Bruceae extract are prepared using following preparation method：By the drying of fresh Java brucea sample, crush, the methanol eddy for adding 8 times of material quantities thereto extracts 2 times, filtering, merge No. 2 extract solutions, extract solution reduced-pressure backflow solvent adds water to be centrifuged after 30-40 DEG C of suspensions, standing to paste, upper strata suspension is first extracted 3 times with chloroform, and recovery chloroform layer solvent obtains Java brucea extract solution.Cordate houttuynia essence, Fructus Bruceae extract, poplar flower extract interaction and composition of prescription are subjected to pharmaceutical research in the present composition, prove three kinds of mutual Synergistics of extract, in bacteriostasis, hence it is evident that better than the single extract of use as active principle.
Description
Technical field
The present invention relates to pharmaceutical technology field, and in particular to a kind of cordate houttuynia essence combination.
Background technology
Cordate houttuynia is on saururaceae plant houttuynia cordata Houttuynia cordataThunb. fresh herb or dry ground
Part.With clearing heat and detoxicating, the carbuncle that disappears apocenosis, the effect of inducing diuresis for treating strangurtia.Be mainly used in treat lung carbuncle pyemesis, phlegm heat panting cough, hot dysentery,
Heat gonorrhea, carbuncle sore tumefacting virus.Sodium New Houttuyfonate (SodiumNew Houttuyfonat) is the one kind extracted from cordate houttuynia herb
The synthetics of aldehydes single active ingredient, the entitled Sodium New Houttuyfonate of chemistry, have antibacterial, anti-inflammatory and antalgic,
Effect that is antitumor, promoting immune raising body's immunity；To Diplococcus pneumopniae, typhoid bacillus, staphylococcus aureus,
Escherichia coli and sporothrix etc. have obvious inhibiting effect, can improve the phagocytic function of immunity of organisms enhancing patient's leucocyte,
It is horizontal to improve serum properdin, improves body non-specific immunity；For gynaecology such as adnexitis, pelvic infecton, chronic cervicitis
All kinds of inflammation, and can be used for the infection in respiratory system such as the infection of the upper respiratory tract, chronic bronchopneumonia, viral pneumonia.
Poplar flower, alias Chinese parasol tree tree awns, willow are hung, and pathogen can directly be suppressed by having, and improve the resistance of body, confrontation is exempted from
Epidemic disease inhibitor, adjust the immunologic function of body, effectively alleviate livestock and poultry morbidity during various stress reactions, make animal intestines and stomach flesh and
Sphincter tone improves.
Java brucea, the old duck courage of alias, makees Chinese medicine, and bitter is cold in nature, there is clearing heat and detoxicating, stop dysentery disease and other effects.
Modern pharmacology and pharmacodynamic study show houttuynia extract in antibacterial, anti-inflammatory, antipyretic-antalgic, antibacterial aspect tool
There is the effect of fine, and only have houttuynia extract at present and carry out sale listing as the preparation of single active principle, but together
Shi Liyong houttuynia extracts, poplar flower extract, Fructus Bruceae extract have not been reported as active principle compatibility component.
Based on this, a kind of cordate houttuynia essence combination has been researched and developed.
The content of the invention
The present invention provides a kind of cordate houttuynia essence combination, is based primarily upon clinical needs, while using cordate houttuynia essence, crow
Courage extract, poplar flower extract are used as active ingredient simultaneously, in terms of antipyretic-antalgic have it is more preferable the effect of.
The present invention is achieved through the following technical solutions：
A kind of cordate houttuynia essence combination, in terms of parts by weight, the composition includes following component：Cordate houttuynia essence
20-30 parts, 10-20 parts of antioxidant, 20-50 parts of poplar flower extract, 5-10 parts of Fructus Bruceae extract, the cordate houttuynia
Essence is prepared using following preparation method：Using cordate houttuynia herb, cordate houttuynia root at least one as raw material, crush, add second
Alcohol or the immersion of methanol or water, take soak, are drying to obtain；The Fructus Bruceae extract is prepared using following preparation method：
By the drying of fresh Java brucea sample, crush, the methanol eddy for adding 8 times of material quantities thereto extracts 2 times, filtering, merges 2 times and carries
Liquid is taken, extract solution reduced-pressure backflow solvent to paste, adds water to be centrifuged after 30-40 DEG C of suspensions, standing, upper strata suspension first uses chlorine
Imitative to extract 3 times, recovery chloroform layer solvent obtains Java brucea extract solution.
Cordate houttuynia (English name HERBA HOUTTUYNIAE) is the herbal medicine that Chinese Pharmacopoeia is included, and herbal medicine source is saururus chinensis
Section's plant heartleaf houttuynia (Classification system:Houttuynia cordata Thunb.) dry aerial parts.The luxuriant flower spike of summer cauline leaf
Tapped when more, remove impurity, dry.
Herbal medicine character:Stem is in oblate cylindricality, distortion, long 20~35cm, 0.2~0.3cm of diameter；Surface brown color, tool are vertical
Rib several, section is obvious, has remaining fibrous root on the section of bottom；Matter is crisp, frangibility.Leaf alternate, blade convolution shrinkage, it is in the heart after flattening
Shape, long 3~5cm, wide 3~4.5cm；Tip is tapering, full edge；Upper surface darker yellow green is to burgundy, lower surface celadon or ash
Brown；Petiole is elongated, and base portion and stipule symphysis are into sheath shape.Spike basidixed, yellowish-brown.Rub the broken taste that bears the odor of fish with the hands.
Cordate houttuynia acrid flavour, cold, return lung warp.Can sore be treated in clearing heat and detoxicating, detumescence, promoting urination and removing dampness, clearing away heat to cure dysentery, stomach invigorating disappear
Food, with control real heat, heat toxin, damp evil, disease heat be suffer from lung carbuncle, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc..Modern pharmacology is real
Test and show, this product has the effect such as antibacterial, antiviral, raising immunity of organisms, diuresis.
Cordate houttuynia essence, also known as houttuynia extract, it uses following preparation method to be prepared：With cordate houttuynia herb,
Cordate houttuynia root at least one is raw material, is crushed, and adds ethanol or methanol or water to soak, takes soak, be drying to obtain.
Poplar flower is the drying male inflorescence of Salicaceous Plants Chinese white poplar, eugene poplar or sibling species plant, and clinic is mainly controlled
Treat damp-heat diarrhea, cub diarrhea.Wherein containing abundant flavone compound, wide material sources, use cost is low, can preferably drop
Low production cost, and noresidue, pathogen do not produce drug resistance, pollution-free to production environment.Think from traditional Chinese medical science angle, willow
The effect of flower is with clearing heat and detoxicating, relieving diarrhea with astringents, strengthening spleen and nourishing stomach and dampness elimination stop dysentery.
Flavone compound, polysaccharide compound, organic acid, several amino acids and life are wherein can extract out in poplar flower
The compositions such as alkaloids class, and poplar flower is also containing abundant vitamin, inorganic salts, several mineral materials and trace element, these materials
All there is very high nutrition and medical value.And the flavone compound extracted, its pharmacological action include Regulation serum lipids, anti-oxidant
Acted on effect of scavenging radical, antibacterial action, antitumor action, Central nervous system etc..
Java brucea, Java brucea, also known as crow courage, crow courage, bitter fibert, khosem, crow egg-shaped thing, duck's egg, Fructus Bruceae, solution are bitter
Chinaberry, small China tree.Latin literary fame Brucea javanica. are Simarubaceae, brucea plant evergreen shrubs or dungarunga, complete stool
By yellow pubescence.Sprig has yellow-white hole skin.Imparipinnate leaf alternate, usual 7, to life, ovum shape lanceolar, tip
It is tapering, base portion wide wedge shape, deflection, edge tool triangle rough sawn tooth, dredge above by, following Mi Bifu pubescences, it is outstanding close on arteries and veins.Poly- umbrella
Shape panicle axillary, it is long and narrow, it is born in 950~1000m of height above sea level lime mountain sparse woods.
Java brucea, as Chinese medicine in use, bitter, cold in nature, there is clearing heat and detoxicating, stop dysentery disease effect.
Antioxidant in the technical program, concretely matrimony vine or the Radix Astragali or pseudo-ginseng or the red sage root or hawthorn, what this was mentioned
Antioxidant, which is respectively provided with, removes free radical, anti-oxidant, anti-aging effect.
And the component in the technical program in cordate houttuynia essence combination, 20-30 parts of cordate houttuynia essence, antioxidant
10-20 parts, 20-50 parts of poplar flower extract, 5-10 parts of Fructus Bruceae extract is that inventor draws through largely groping summary,
Each component dosage is respectively provided with good therapeutic effect in the range of the weight fraction.
Composition described above be by weight as proportioning, as mass produce when can by kilogram in units of or using ton for list
Position, can be in grams during small-scale production.
Preferably, in the preparation method of the cordate houttuynia essence, adopt and be soaked in water, addition water is 2-10 times of raw material.
Preferably, in the preparation method of the cordate houttuynia essence, soaked using ethanol or methanol, the addition of ethanol or methanol
Measure as 2-5 times of raw material, concentration of alcohol is 35-65%, and methanol concentration is 50-60%.
Preferably, using the cordate houttuynia essence, Fructus Bruceae extract, poplar flower extract of effective dose as active component, add
The medicament that pharmaceutically acceptable auxiliary material forms.
Preferably, the medicament is oral formulations.
The present invention proves by pharmacology and drug effect zooscopy result, with cordate houttuynia essence, poplar flower extract, crow courage
Seed extract is prepared into medicine, has obvious suppression to make to staphylococcus aureus, Diplococcus pneumopniae, shigella dysenteriae, typhoid bacillus
With.
The present invention compared with prior art, has the following advantages and advantages：
(1) the technical program provides a kind of Chinese medicine composition compound, meets clinical needs, and each extract is matched and carried out
Pharmacodynamic study, the optimal proportion of the present composition is drawn.
(2) by cordate houttuynia essence, Fructus Bruceae extract, poplar flower extract interaction and compatibility in the present composition
Prescription carries out pharmaceutical research, it was demonstrated that three kinds of mutual Synergistics of extract, hence it is evident that effective better than being used as using single extract
Component.
Embodiment
For the object, technical solutions and advantages of the present invention are more clearly understood, with reference to embodiment, the present invention is made
Further to describe in detail, exemplary embodiment of the invention and its explanation are only used for explaining the present invention, are not intended as to this
The restriction of invention.
Embodiment 1：
A kind of cordate houttuynia essence combination, in terms of parts by weight, the composition includes following component：Cordate houttuynia essence
20-30 parts, 10-20 parts of saw palmetto oil, 20-50 parts of poplar flower extract, 5-10 parts of Fructus Bruceae extract, the cordate houttuynia
Essence is prepared using following preparation method：Using cordate houttuynia herb, cordate houttuynia root at least one as raw material, crush, add second
Alcohol or the immersion of methanol or water, take soak, are drying to obtain；The Fructus Bruceae extract is prepared using following preparation method：
By the drying of fresh Java brucea sample, crush, the methanol eddy for adding 8 times of material quantities thereto extracts 2 times, filtering, merges 2 times and carries
Liquid is taken, extract solution reduced-pressure backflow solvent to paste, adds water to be centrifuged after 30-40 DEG C of suspensions, standing, upper strata suspension first uses chlorine
Imitative to extract 3 times, recovery chloroform layer solvent obtains Java brucea extract solution.
Wherein, in the preparation method of the cordate houttuynia essence, adopt and be soaked in water, addition water is 2-10 times of raw material.
Wherein, in the preparation method of the cordate houttuynia essence, soaked using ethanol or methanol, the addition of ethanol or methanol
For 2-5 times of raw material, concentration of alcohol is 35-65%, and methanol concentration is 50-60%.
Wherein, using the cordate houttuynia essence, Fructus Bruceae extract, poplar flower extract of effective dose as active component, medicine is added
The medicament that acceptable auxiliary material forms on.
Wherein, the medicament is oral formulations.
Above-described embodiment, the purpose of the present invention, technical scheme and beneficial effect are carried out further
Describe in detail, should be understood that the embodiment that the foregoing is only the present invention, be not intended to limit the present invention
Protection domain, within the spirit and principles of the invention, any modification, equivalent substitution and improvements done etc., all should include
Within protection scope of the present invention.
Claims (5)
- A kind of 1. cordate houttuynia essence combination, it is characterised in that：In terms of parts by weight, the composition includes following component：Fish 20-30 parts of raw meat hay-scented essence, 10-20 parts of antioxidant, 20-50 parts of poplar flower extract, 5-10 parts of Fructus Bruceae extract, institute State that houttuynia allspice is wonderful to be prepared with following preparation method：Using cordate houttuynia herb, cordate houttuynia root at least one as raw material, powder It is broken, add ethanol or methanol or water to soak, take soak, be drying to obtain；The Fructus Bruceae extract uses following preparation method system It is standby to form：By the drying of fresh Java brucea sample, crush, the methanol eddy for adding 8 times of material quantities thereto extracts 2 times, filters, and closes And No. 2 extract solutions, extract solution reduced-pressure backflow solvent to paste, add water to be centrifuged after 30-40 DEG C of suspensions, standing, upper strata suspension First extracted 3 times with chloroform, recovery chloroform layer solvent obtains Java brucea extract solution.
- A kind of 2. cordate houttuynia essence combination according to claim 1, it is characterised in that：The preparation of the cordate houttuynia essence In method, adopt and be soaked in water, addition water is 2-10 times of raw material.
- A kind of 3. cordate houttuynia essence combination according to claim 1, it is characterised in that：The preparation of the cordate houttuynia essence In method, to be soaked using ethanol or methanol, the addition of ethanol or methanol is 2-5 times of raw material, concentration of alcohol is 35- 65%, methanol concentration is 50-60%.
- A kind of 4. cordate houttuynia essence combination according to claim 2, it is characterised in that：With the houttuynia allspice of effective dose Essence, Fructus Bruceae extract, poplar flower extract are active component, add the medicament that pharmaceutically acceptable auxiliary material forms.
- A kind of 5. cordate houttuynia essence combination according to claim 4, it is characterised in that：The medicament is oral formulations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201710722628.6A CN107362225A (en) | 2017-08-22 | 2017-08-22 | A kind of cordate houttuynia essence combination |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710722628.6A CN107362225A (en) | 2017-08-22 | 2017-08-22 | A kind of cordate houttuynia essence combination |
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| CN107362225A true CN107362225A (en) | 2017-11-21 |
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| CN201710722628.6A Pending CN107362225A (en) | 2017-08-22 | 2017-08-22 | A kind of cordate houttuynia essence combination |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020105149A (en) * | 2018-12-28 | 2020-07-09 | 小林製薬株式会社 | Oral composition |
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- 2017-08-22 CN CN201710722628.6A patent/CN107362225A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020105149A (en) * | 2018-12-28 | 2020-07-09 | 小林製薬株式会社 | Oral composition |
| JP7229767B2 (en) | 2018-12-28 | 2023-02-28 | 小林製薬株式会社 | oral composition |
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Application publication date: 20171121 |