CN107347900A - A kind of bactericidal composition of the urethane of pyrrole containing tetrazolium - Google Patents
A kind of bactericidal composition of the urethane of pyrrole containing tetrazolium Download PDFInfo
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- CN107347900A CN107347900A CN201710660469.1A CN201710660469A CN107347900A CN 107347900 A CN107347900 A CN 107347900A CN 201710660469 A CN201710660469 A CN 201710660469A CN 107347900 A CN107347900 A CN 107347900A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
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Abstract
The invention discloses a kind of bactericidal composition of urethane of pyrrole containing tetrazolium and its application, effective active composition is made up of one kind in the first active component tetrazolium pyrrole urethane and the second active component methoxy acrylic bactericide SYP-3375, famoxadones, Fenamidone, and the weight ratio of the first active component and the second active component is 1：80~60：1, preferably 1：60~40：1.Wettable powder that this composition can be configured to agriculturally to allow, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, microcapsule suspension suspending agent, dispersible oil-suspending agent, dry suspension formulation.Instant component is reasonable, and bactericidal effect is good, and its activity and bactericidal effect are not the simple superposition of each component activity, compared with existing unitary agent, in addition to significant bactericidal effect, and have significant synergistic effect, good to crop safety.The present invention has significant prevention effect to crop downy mildew, epidemic disease.
Description
Technical field
The present invention relates to a kind of bactericidal composition, by the first active component tetrazolium pyrrole urethane and the second active component methoxyl group
Acrylic bactericide SYP-3375, famoxadones, one kind in Fenamidone and auxiliary agent composition, belong to Recompounded pesticide technology
Field.
Background technology
Tetrazolium pyrrole urethane, English name picarbutrazox, it is the carbamate sterilization that Japanese Cao Da companies develop
Agent.The mechanism of action of tetrazolium pyrrole urethane is indefinite at present, the bactericide world resistance committee（FRAC）It is classified as independent U17
It is a kind of.To disease significant effect caused by downy mildew, epidemic disease and pythium spp under tetrazolium pyrrole urethane 50ppm dosage, prevention is biased toward
Protecting effect, while have and inhaled in cross-layer and certain therapeutic activity.
SYP-3375, English name coumoxystrobin, chemical name：(E) -2- (2- ((3- butyl -4- methyl-tonka-bean
Element -7- bases epoxide) methyl) phenyl) -3- methoxy-methyl acrylates.SYP-3375 is developed by Shenyang Chemical Engineering Inst, Jilin
The eight a high-end bactericide developed up to agricultural chemicals Co., Ltd are saved, belongs to methoxy acrylic, is a kind of protective fungicide
Agent, while have certain therapeutic action concurrently.It has wide spectrum, low toxicity, it is efficient, safe the characteristics of, have it is immune, prevention, treatment, increase
Produce the effect of increasing income.Wide sterilization spectrum, to apple tree canker special efficacy, to melon fruits and vegetables, fruit tree downy mildew, late blight, scab,
Anthracnose, leaf mold are effective；Simultaneously to ring spot, anthracnose, cotton wilt, rice pestilence, banded sclerotial blight, Root Rot of Wheat
Disease, corn southern leaf blight are also effective.
Famoxadone, English name famoxadone, chemical name：3- anilino- -5- methyl -5- (4- Phenoxyphenyls) -
1,3- oxazoline -2,4- diketone.Famoxadone belongs to inhibitor of energy, i.e. Mitochondrial electron transmits inhibitor；To in complex III
Cytochrome c oxidoreductase has inhibitory action, with phenyl amide series bactericidal agent without friendship resistance.
Fenamidone, English name fenamidone, chemical name：(S) -1- phenylaminos -4- methyl -2- methyl mercapto -4- benzene
Base -2- imidazoline-5-ketones.Fenamidone is the novel imidazolone bactericide developed by Ainwunt Crop Scientifique, is had
Tag, permeate, systemic activity, there is good protection and therapeutic activity again.Except to the fungus-caused mycosis of Oomycete class, epidemic disease
Etc. having, good activity is outer, also has good activity to fruit tree black spot.
There is presently no tetrazolium pyrrole urethane and methoxy acrylic bactericide SYP-3375, famoxadones, imidazoles bacterium
A kind of mixture preventing and treating downy mildew, the document report of epidemic disease in ketone, are further advanced by experiment and find, the mechanism of action is different
A kind of compounding in tetrazolium pyrrole urethane and methoxy acrylic bactericide SYP-3375, famoxadones, Fenamidone, has
Unexpected effect, not only synergistic effect is notable, moreover it is possible to significantly improves to crop downy mildew, the prevention effect of epidemic disease, reduces
Dosage, cost accounting is reduced, to crop safety.
The content of the invention
It is an object of the invention to provide a kind of component is reasonable, synergistic effect is notable, and bactericidal effect is good, and drug cost is low,
To the bactericidal composition of the urethane of pyrrole containing tetrazolium of crop safety.
Another object of the present invention is to provide the bactericidal composition preparation formulation of the urethane of pyrrole containing tetrazolium.
It is still another object of the present invention to provide application of the above-mentioned composition in preventing and treating crop downy mildew, epidemic disease.
The defects of in order to overcome existing unitary agent, the technical scheme is that so solve：
A）First active component tetrazolium pyrrole urethane；
B）One kind in second active component methoxy acrylic bactericide SYP-3375, famoxadones, Fenamidone；
The weight of first active component and the second active component ratio is 1：80~60：1, preferably 1：60~40：1.
A kind of bactericidal composition of the urethane of pyrrole containing tetrazolium of the present invention is according to the method well known to those skilled in the art of the present technique
The preparation formulation that can be prepared is that wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, micro-capsule hang
Floating agent, microcapsule suspension-suspendinagent agent, dispersible oil-suspending agent, dry suspension.
To wettable powder, workable auxiliary agent has：Dispersant such as polycarboxylate, lignosulfonates, polyoxyethylene gather
Oxypropylene group ether block copolymers, alkyl naphthalene formaldehyde condensate sulfonates, alkylphenol-polyethenoxy base ether phosphate, poly alkyl alcohol
Oxygen ethene ether phosphate, it is one or more in alkylphenol-polyethenoxy base ether sulfonate；Wetting agent such as alkyl sulfate, alkyl sulphur
One or more in hydrochlorate, alkylnaphthalene sulfonate；Filler for example ammonium sulfate, urea, sucrose, glucose, diatomite, kaolin,
One or more in white carbon, fine particle calcium carbonate, talcum powder, attapulgite, clay.
To water dispersible granules, workable auxiliary agent has：Dispersant such as polycarboxylate（TERSPERSE 2700、T36、GY-
D06 etc.）, lignosulfonates, the one or more in alkylnaphthalene sulfonate；Wetting agent for example alkyl sulfate, alkylsulfonate,
One or more in naphthalene sulfonate；It is disintegrant such as ammonium sulfate, sodium sulphate, polyvinylpyrrolidone, starch and its derivative, swollen
One or more in profit soil；Binding agent such as starch, glucose, polyvinyl alcohol, polyethylene glycol, sodium carboxymethylcellulose, sucrose
In one or more；Filler such as one kind in diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, clay or
It is a variety of.
To suspending agent, workable auxiliary agent has：Dispersant such as polycarboxylate, lignosulfonates, alkyl naphthalene formaldehyde condensation
Thing sulfonate, alkylphenol-polyethenoxy base ether phosphate, alkylphenol-polyethenoxy base ether sulfonate, phenethyl phenol polyoxyethylene groups
Ether phosphate, alkyl polyoxyethylene ether sulfonate, polyoxyethylene polyoxypropylene base ether block copolymers, pull open powder, dodecyl
One or more in polyoxyethylene ether phosphate；Wetting agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products sulfate, benzene
Ethyl phenol polyoxyethylene groups ether phosphate, alkyl sulfate, alkylsulfonate, alkylnaphthalene sulfonate, alkylphenol-formaldehyde resin gather
One or more in oxygen vinethene, triphenoethyl benzene phenol polyoxyethylene polyoxypropylene block polymer；Thickener such as xanthans,
One or more in polyvinyl alcohol, bentonite, aluminium-magnesium silicate, carboxymethyl cellulose, carboxyethyl cellulose, methylcellulose；
One or more in preservative such as formaldehyde, benzoic acid, sodium benzoate, potassium sorbate, OIT；Defoamer such as silicone oil,
Silicone compound, C10-20 saturated fat acid compounds, C8-10 aliphatic alcohols, hexanol, butanol, one kind in octanol or
It is a variety of；Antifreezing agent such as one kind or more in ethylene glycol, propane diols, glycerine, polyethylene glycol, sorbierite, urea, inorganic salts
Kind；Water is deionized water.
To suspension emulsion, workable auxiliary agent has：Emulsifying agent such as calcium dodecyl benzene sulfonate（Agriculture breast 500#）, Nongru-700 #,
Agriculture breast 2201, this disk -60#, emulsifying agent T-60（Common name：Anhydrous sorbitol single-hard ester acid ester APEO）、TX-10（It is logical
With name：Octyl phenol polyoxyethylene（10）Ether）, agriculture breast 1601#, agriculture breast 600#, the one or more in agriculture breast 400#；Dispersant is such as
It is one or more in polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate；Solvent such as repefral, adjacent benzene two
It is one or more in formic acid dibutyl ester, ethyl acetate, methyl benzoate；Defoamer is as such as silicone oil, silicone compound, C10-20
One or more in saturated fat acids compound, C8-10 aliphatic alcohols, hexanol, butanol, octanol；Thickener such as white carbon,
It is one or more in polyvinyl alcohol, bentonite, aluminium-magnesium silicate；Antifreeze such as ethylene glycol, propane diols, glycerine, urea, inorganic salts
Such as one or more in sodium chloride；Water is deionized water.
To aqueous emulsion, workable auxiliary agent has：Emulsifying agent such as Nonyl pheno（EO=10）Ether phosphate, triphen second
Base phenol polyoxyethylene phosphonate, Nongru-700 #（Common name：Alkyl phenol formaldehyde resin polyoxyethylene ether）, agriculture breast 2201#, this
Disk -60#（Common name：Span60）, Tween-60 #（Common name：Polyoxyethylene sorbitan stearic acid
Ester）、TX-10（Common name：Octyl phenol polyoxyethylene（10）Ether）, agriculture breast 1601（Common name：Triphenoethyl benzene phenol polyoxypropylene gathers
Oxygen ethylene block polymer）, it is agriculture breast 600#, one or more in agriculture breast 400#；Solvent such as dimethylbenzene, toluene, cyclohexanone, solvent
Oil（The trade mark：S-150、S-180、S-200）It is one or more；Stabilizer such as triphenyl phosphite, epoxychloropropane, epoxy soybean
It is one or more in oil；Antifreezing agent：It is one or more in ethylene glycol, propane diols, glycerine, urea, inorganic salts such as sodium chloride；Increase
It is one or more in thick dose such as xanthans, polyvinyl alcohol, bentonite, aluminium-magnesium silicate；Preservative such as formaldehyde, benzoic acid, benzoic acid
One or more in sodium, water is deionized water.
For microemulsion, workable auxiliary agent has：Emulsifying agent is selected from calcium dodecyl benzene sulfonate（Agriculture breast 500#）, agriculture breast
700#, agriculture breast 2201, this disk-60#, polysorbate60-#, TX-10, agriculture breast 1601（Common name：Phenethyl phenol polyoxyethylene polyoxy
Propylene ether）, agriculture breast 600#, agriculture breast 400#；Assistant for emulsifying agent is selected from methanol, isopropanol, n-butanol, ethanol；Solvent be selected from cyclohexanone,
1-METHYLPYRROLIDONE, dimethylbenzene, toluene, solvent naphtha（The trade mark：S-150、S-180、S-200）；Stabilizer is selected from phosphorous acid three
Phenyl ester, epoxychloropropane；Water is deionized water.
To microcapsule suspending agent, workable auxiliary agent has：Macromolecule cyst material for example polyfunctional group acyl halide polyamines, gelatin,
It is one or more in Arabic gum, deformation lactoprotein, sodium alginate；Dispersant such as aliphatic alcohol polyethenoxy base ether, alkyl phenol gather
It is one or more in the phonetic formaldehyde condensation products sulfate of oxygen ethene, alkylbenzenesulfonate；Solvent such as fatty acid ester, linseed oil, oleic acid
It is one or more in methyl esters；Emulsifying agent such as benzyl dimethyl phenol polyoxyethyl ether, phenethyl phenol polyoxyethanyl polypropylene-base ether, ring
It is one or more in oxidative ethane-propylene oxide block copolymer；PH conditioning agents such as sodium hydroxide and hydrochloric acid, citric acid, sorbic acid
Middle one or more；It is a kind of or more in defoamer such as C8-10 aliphatic alcohols, acid amides, organic silicon defoamer, hexanol, butanol, octanol
Kind；Water is deionized water.
To microcapsule suspension-suspendinagent agent, workable auxiliary agent has：Disintegrant such as bentonite, urea, ammonium sulfate, polyethylene pyrrole
One or more in pyrrolidone, glucose, sodium acid carbonate；Preservative such as formaldehyde, benzoic acid, sodium benzoate, potassium sorbate, different
One or more in thiazolinone etc.；Emulsifying agent such as AEO, aliphatic acid polyethenoxy ether, detergent alkylate
Sulfoacid calcium, APES, styrylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, sorbitol anhydride list are hard
One or more in resin acid ester, sorbitan monostearate APEO, aliphatic acid polyethenoxy ether phosphate etc.；
Dispersant such as polycarboxylate, lignosulfonates, alkylphenol-polyethenoxy base ether formaldehyde condensation products sulfate（SOPA）, naphthalene and alkane
Base naphthalene formaldehyde condensate sulfonates class, EO-PO block polyethers class, alkylphenol-polyethenoxy base ether phosphate, alkyl phenol polyoxy second
One kind or more in alkene ether, polyoxyethylene carboxylate, aliphatic amine polyoxyethylene ether, glycerine fatty acid ester APEO etc.
Kind；Wetting agent such as lauryl sodium sulfate, neopelex, Nekal BX, moistening bleeding agent F, naphthalene sulphonate formaldehyde
One or more in condensation product etc.；One or more in antifreezing agent such as urea, ethylene glycol, propane diols, glycerine；Thickening
One kind in agent such as xanthans, carboxymethyl cellulose, carboxyethyl cellulose, methylcellulose, aluminium-magnesium silicate, polyvinyl alcohol or
It is a variety of；Defoamer such as organic silicone oil, silicone compound, C10-20 saturated fat acid compounds, C8-10 fatty alcohols, ester ether
One or more in class etc..
To dispersible oil-suspending agent, workable auxiliary agent has：Dispersant such as polycarboxylate, lignosulfonates, alkylnaphthalene
Sulfonate（Dispersing agent NNO）、TERSPERSE 2020（Huntsman Corporation of U.S. HUNTSMAN produces, alkyl naphthalene sulfonic acid salt）In
It is one or more；Emulsifying agent such as BY（Castor oil polyoxyethylene ether）Serial emulsifying agent（BY-110、BY-125、BY-140）, agriculture breast
700#（Common name：Alkyl phenol formaldehyde resin polyoxyethylene ether）, agriculture breast 2201, this disk -60#（Common name：Sorbitol anhydride list is stearic
Acid esters）, Tween-60 #（Common name：Sorbitan monostearate APEO）, agriculture breast 1601#（Common name：Phenethyl
Phenol polyoxyethylene poly-oxygen propylene aether）、TERSPERSE 4894（Huntsman Corporation of the U.S. produces）In one or more；Wetting
Agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products sulfate, APES phosphate, phenethyl phenol polyoxy second
Alkenyl ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, TERSPERSE 2500（Huntsman Corporation of the U.S. goes out
Product）Middle one or more；It is one or more in thickener such as white carbon, polyvinyl alcohol, bentonite, aluminium-magnesium silicate；Antifreezing agent is such as
It is one or more in ethylene glycol, propane diols, glycerine, urea, inorganic salts such as sodium chloride；Decentralized medium for example soybean oil, rapeseed oil,
It is one or more in small wheat oil, methyl oleate, diesel oil, machine oil, mineral oil.
To dry suspending agent, workable auxiliary agent has：Dispersant such as lauryl sodium sulfate, polycarboxylate, acrylic acid homopolymerization
Oxygen sodium salt, dioctyl sodium sulphosuccinate, Teepol, neopelex, fatty acid polyethylene glycol ester, alkane acyl
Amido taurate, HPMC, AEO, sodium naphthalene sulfonate, Negel, aliphatic acid sulphur alkane
One or more in base ester, lignosulfonates etc.；Wetting agent such as lauryl sodium sulfate, Negel, dodecane
In base benzene sulfonic acid sodium salt, sodium lignin sulfonate, Negel formaldehyde condensation products, alkylphenol-polyethenoxy base ether, pull open powder etc.
One or more；Disintegrant such as phosphate, sulfate, carbonate, urea, sodium chloride, bentonite, polyvinylpyrrolidone etc.
In one or more；Binding agent such as Arabic gum, carboxymethyl cellulose, polyvinyl alcohol, polyethylene glycol, polyvinylpyrrolidone
One or more in；Defoamer such as silicone oil, silicone compound, C10-20 saturated fat acid compounds, C8-10 fat
One or more in alcohols, hexanol, butanol, octanol etc.；Carrier such as diatomite, precipitated calcium carbonate, tripoli, kaolin, hard charcoal
One or more in black, attapulgite etc..
Instant component is reasonable, and treatment plus protective effect, bactericidal effect is good, and drug cost is low, and its activity and sterilization effect
Fruit is not the simple superposition of each component activity, but has significant synergistic effect, good to crop safety, meets pesticidal preparations
Security requirement.The present invention has excellent prevention effect to crop downy mildew, epidemic disease.
Embodiment
1st, the synergy measure to downy mildew mixture.
In order to prevent and treat the downy mildew in agricultural production, we are with tetrazolium pyrrole urethane and methoxy acrylic bactericide fourth
Fragrant bacterium Zhi, famoxadones, Fenamidone have carried out the synergy research of mutual compounding respectively, and specific method is as follows.
Subjects are bacterium of downy mildew of cucumber（Pseudoperonospora cubensis）.Active compound is configured to what is needed
Test medicine, test method use pot-culture method.
Single dose and each Mixed Pharmacy are set into 5 various concentrations gradients first（On the basis of pilot study, bacteriostasis rate exists
Set in the range of 5%~90% by geometric progression）.If blank control, being repeated 4 times, 5 basins are often handled, per 2 plants of basin.Decoction is equal
It is even to spray in blade face, it is standby after decoction natural air drying.With spore suspension spray inoculation, natural air drying, constant temperature is then moved to
Room, it is 17~22 DEG C in temperature, under conditions of relative humidity more than 90%, culture.Treat that blank control disease leaf rate reaches more than 80%
When, inoculation blade is investigated.Grade scale is：
0 grade：It is disease-free；
1 grade：Lesion area accounts for less than the 5% of whole leaf area；
3 grades：Lesion area accounts for the 6%~10% of whole leaf area；
5 grades：Lesion area accounts for the 11%~25% of whole leaf area；
7 grades：Lesion area accounts for the 26%~50% of whole leaf area；
9 grades：Lesion area accounts for more than the 50% of whole leaf area；
According to survey data, the disease index and prevention effect of each processing are calculated.Pass through pair of preventive effect niqueMin and series concentration
Linear regression analysis between numerical value, obtain the EC50 values of each medicament.
The co-toxicity coefficient of mixture is calculated with the abundant methods of Sun Yun（CTC）, activity of the reagent agent to germ is evaluated with this.Compounding
The co-toxicity coefficient of preparation（CTC）>=120 show as synergistic effect；CTC≤80 show as antagonism；80 ＜ CTC ＜ 120 are showed
For summation action.
The tetrazolium pyrrole urethane of table 1 and SYP-3375 combine the Toxicity Determination to cucumber downy mildew
| Chemicals treatment | ED50（mg/L） | ATI | TTI | CTC |
| Tetrazolium pyrrole urethane（A） | 2.24 | 100.00 | —— | —— |
| SYP-3375（B） | 3.54 | 63.28 | —— | —— |
| A:B=1:90 | 3.32 | 67.47 | 63.68 | 105.95 |
| A:B=1:80 | 2.69 | 83.27 | 63.73 | 130.66 |
| A:B=1:70 | 2.54 | 88.19 | 63.79 | 138.24 |
| A:B=1:60 | 2.45 | 91.43 | 63.88 | 143.13 |
| A:B=1:50 | 2.39 | 93.72 | 64.00 | 146.45 |
| A:B=1:40 | 2.24 | 100.00 | 64.17 | 155.83 |
| A:B=1:30 | 2.05 | 109.27 | 64.46 | 169.51 |
| A:B=1:20 | 1.98 | 113.13 | 65.03 | 173.98 |
| A:B=1:10 | 1.96 | 114.29 | 66.62 | 171.56 |
| A:B=1:1 | 1.65 | 135.76 | 81.64 | 166.29 |
| A:B=10:1 | 1.43 | 156.64 | 96.66 | 162.05 |
| A:B=20:1 | 1.47 | 152.38 | 98.25 | 155.09 |
| A:B=30:1 | 1.58 | 141.77 | 98.82 | 143.47 |
| A:B=40:1 | 1.65 | 135.76 | 99.10 | 136.98 |
| A:B=50:1 | 1.72 | 130.23 | 99.28 | 131.18 |
| A:B=60:1 | 1.74 | 128.74 | 99.40 | 129.52 |
| A:B=70:1 | 2.21 | 101.36 | 99.48 | 101.88 |
The tetrazolium pyrrole urethane of table 2 is He famoxadone combines the Toxicity Determination to cucumber downy mildew
| Chemicals treatment | ED50（mg/L） | ATI | TTI | CTC |
| Tetrazolium pyrrole urethane（A） | 2.24 | 100.00 | —— | —— |
| Famoxadone（B） | 12.38 | 18.09 | —— | —— |
| A:B=1:90 | 10.23 | 21.90 | 18.99 | 115.28 |
| A:B=1:80 | 9.02 | 24.83 | 19.10 | 129.99 |
| A:B=1:70 | 8.53 | 26.26 | 19.25 | 136.44 |
| A:B=1:60 | 8.24 | 27.18 | 19.44 | 139.86 |
| A:B=1:50 | 7.84 | 28.57 | 19.70 | 145.03 |
| A:B=1:40 | 7.21 | 31.07 | 20.09 | 154.63 |
| A:B=1:30 | 6.52 | 34.36 | 20.74 | 165.68 |
| A:B=1:20 | 5.97 | 37.52 | 21.99 | 170.60 |
| A:B=1:10 | 5.12 | 43.75 | 25.54 | 171.30 |
| A:B=1:1 | 2.32 | 96.55 | 59.05 | 163.52 |
| A:B=10:1 | 1.52 | 147.37 | 92.55 | 159.22 |
| A:B=20:1 | 1.54 | 145.45 | 96.10 | 151.36 |
| A:B=30:1 | 1.59 | 140.88 | 97.36 | 144.70 |
| A:B=40:1 | 1.62 | 138.27 | 98.00 | 141.09 |
| A:B=50:1 | 1.67 | 134.13 | 98.39 | 136.32 |
| A:B=60:1 | 1.84 | 121.74 | 98.66 | 123.40 |
| A:B=70:1 | 2.12 | 105.66 | 98.85 | 106.89 |
The tetrazolium pyrrole urethane of table 3 and Fenamidone combine the Toxicity Determination to cucumber downy mildew
| Chemicals treatment | ED50（mg/L） | ATI | TTI | CTC |
| Tetrazolium pyrrole urethane（A） | 2.24 | 100.00 | —— | —— |
| Fenamidone（B） | 2.79 | 80.29 | —— | —— |
| A:B=1:90 | 3.06 | 73.20 | 80.50 | 90.93 |
| A:B=1:80 | 2.16 | 103.70 | 80.53 | 128.78 |
| A:B=1:70 | 2.12 | 105.66 | 80.56 | 131.15 |
| A:B=1:60 | 2.03 | 110.34 | 80.61 | 136.89 |
| A:B=1:50 | 1.98 | 113.13 | 80.67 | 140.23 |
| A:B=1:40 | 1.85 | 121.08 | 80.77 | 149.91 |
| A:B=1:30 | 1.72 | 130.23 | 80.92 | 160.93 |
| A:B=1:20 | 1.82 | 123.08 | 81.23 | 151.53 |
| A:B=1:10 | 1.65 | 135.76 | 82.08 | 165.40 |
| A:B=1:1 | 1.54 | 145.45 | 90.14 | 161.36 |
| A:B=10:1 | 1.46 | 153.42 | 98.21 | 156.22 |
| A:B=20:1 | 1.52 | 147.37 | 99.06 | 148.76 |
| A:B=30:1 | 1.63 | 137.42 | 99.36 | 138.30 |
| A:B=40:1 | 1.61 | 139.13 | 99.52 | 139.80 |
| A:B=50:1 | 1.64 | 136.59 | 99.61 | 137.12 |
| A:B=60:1 | 1.75 | 128.00 | 99.68 | 128.41 |
| A:B=70:1 | 2.31 | 96.97 | 99.72 | 97.24 |
Toxicity Determination result shows：Tetrazolium pyrrole urethane and methoxy acrylic bactericide SYP-3375, famoxadones,
Fenamidone is using weight ratio as 1：80~60：1 mixed has synergistic effect to cucumber downy mildew.
2nd, the synergy measure to epidemic disease mixture.
In order to prevent and treat the epidemic disease in agricultural production, we are with tetrazolium pyrrole urethane and methoxy acrylic bactericide cloves
A kind of synergy research for having carried out mutual compounding in bacterium Zhi, famoxadones, Fenamidone, specific method are as follows.
Subjects are phytophthora infestans（Phytophthora infestans）.The examination that active compound is configured to need
Medicament is tested, test method uses pot-culture method.
Single dose and each Mixed Pharmacy are set into 5 various concentrations gradients first（On the basis of pilot study, bacteriostasis rate exists
Set in the range of 5%~90% by geometric progression）.If blank control, it is repeated 4 times.Potted plant to 2~4 leaf periods of potato,
Decoction is uniformly sprayed on potato leaf surface, it is standby after natural air drying.By zoospore suspension spray inoculation after 24h, connect
Continuous illumination daily/dark lattice 12h alternatings after kind（Intensity of illumination 5000Lux~20000Lux）, temperature be 10~20 DEG C, inoculation
Blade face is kept in 24h afterwards moisture film, later relative humidity be more than 90% under conditions of cultivate 7d.Treat that blank control disease leaf rate reaches
During to more than 50%, incidence is managed in classification investigation everywhere, 30 leaves of often processing investigation.Using following stage division：
0 grade：It is disease-free；
1 grade：Only a small amount of small scab, scab account for less than the 10% of leaf area on blade；
3 grades：Scab accounts for leaf area 10%~25% on blade；
5 grades：Scab accounts for leaf area 25%~50% on blade；
7 grades：Scab accounts for leaf area more than 50% on blade；
9 grades：Full leaf morbidity is withered.
According to survey data, the disease index and prevention effect of each processing are calculated.Pass through preventive effect niqueMin and series concentration
Logarithm value between linear regression analysis, obtain the EC of each medicament50Value.
The co-toxicity coefficient of mixture is calculated with the abundant methods of Sun Yun（CTC）, activity of the reagent agent to germ is evaluated with this.Compounding
The co-toxicity coefficient of preparation（CTC）>=120 show as synergistic effect；CTC≤80 show as antagonism；80 ＜ CTC ＜ 120 are showed
For summation action.
The tetrazolium pyrrole urethane of table 4 and SYP-3375 combine the Toxicity Determination to the late blight of potato
| Chemicals treatment | ED50（mg/L） | ATI | TTI | CTC |
| Tetrazolium pyrrole urethane（A） | 0.42 | 100.00 | —— | —— |
| SYP-3375（B） | 4.21 | 9.98 | —— | —— |
| A:B=1:90 | 3.69 | 11.38 | 10.97 | 103.80 |
| A:B=1:80 | 3.02 | 13.91 | 11.09 | 125.43 |
| A:B=1:70 | 2.93 | 14.33 | 11.24 | 127.48 |
| A:B=1:60 | 2.65 | 15.85 | 11.45 | 138.39 |
| A:B=1:50 | 2.54 | 16.54 | 11.74 | 140.83 |
| A:B=1:40 | 2.31 | 18.18 | 12.17 | 149.37 |
| A:B=1:30 | 2.13 | 19.72 | 12.88 | 153.09 |
| A:B=1:20 | 1.78 | 23.60 | 14.26 | 165.43 |
| A:B=1:10 | 1.52 | 27.63 | 18.16 | 152.15 |
| A:B=1:1 | 0.48 | 87.50 | 54.99 | 159.13 |
| A:B=10:1 | 0.31 | 135.48 | 91.82 | 147.56 |
| A:B=20:1 | 0.31 | 135.48 | 95.71 | 141.55 |
| A:B=30:1 | 0.33 | 127.27 | 97.10 | 131.08 |
| A:B=40:1 | 0.32 | 131.25 | 97.80 | 134.20 |
| A:B=50:1 | 0.32 | 131.25 | 98.23 | 133.61 |
| A:B=60:1 | 0.34 | 123.53 | 98.52 | 125.38 |
| A:B=70:1 | 0.46 | 91.30 | 98.73 | 92.48 |
The tetrazolium pyrrole urethane of table 5 is He famoxadone combines the Toxicity Determination to the late blight of potato
| Chemicals treatment | ED50（mg/L） | ATI | TTI | CTC |
| Tetrazolium pyrrole urethane（A） | 0.42 | 100.00 | —— | —— |
| Famoxadone（B） | 11.25 | 3.73 | —— | —— |
| A:B=1:90 | 7.84 | 5.36 | 4.79 | 111.81 |
| A:B=1:80 | 6.68 | 6.29 | 4.92 | 127.75 |
| A:B=1:70 | 6.34 | 6.62 | 5.09 | 130.17 |
| A:B=1:60 | 5.69 | 7.38 | 5.31 | 138.97 |
| A:B=1:50 | 5.21 | 8.06 | 5.62 | 143.42 |
| A:B=1:40 | 4.52 | 9.29 | 6.08 | 152.80 |
| A:B=1:30 | 3.95 | 10.63 | 6.84 | 155.48 |
| A:B=1:20 | 3.01 | 13.95 | 8.32 | 167.76 |
| A:B=1:10 | 1.96 | 21.43 | 12.48 | 171.64 |
| A:B=1:1 | 0.48 | 87.50 | 51.87 | 168.70 |
| A:B=10:1 | 0.32 | 131.25 | 91.25 | 143.84 |
| A:B=20:1 | 0.31 | 135.48 | 95.42 | 141.99 |
| A:B=30:1 | 0.32 | 131.25 | 96.89 | 135.46 |
| A:B=40:1 | 0.33 | 127.27 | 97.65 | 130.33 |
| A:B=50:1 | 0.31 | 135.48 | 98.11 | 138.09 |
| A:B=60:1 | 0.34 | 123.53 | 98.42 | 125.51 |
| A:B=70:1 | 0.43 | 97.67 | 98.64 | 99.02 |
The tetrazolium pyrrole urethane of table 6 and Fenamidone combine the Toxicity Determination to the late blight of potato
| Chemicals treatment | ED50（mg/L） | ATI | TTI | CTC |
| Tetrazolium pyrrole urethane（A） | 0.42 | 100.00 | —— | —— |
| Fenamidone（B） | 3.13 | 13.42 | —— | —— |
| A:B=1:90 | 3.16 | 13.29 | 14.37 | 92.49 |
| A:B=1:80 | 2.35 | 17.87 | 14.49 | 123.36 |
| A:B=1:70 | 2.14 | 19.63 | 14.64 | 134.08 |
| A:B=1:60 | 2.03 | 20.69 | 14.84 | 139.44 |
| A:B=1:50 | 1.97 | 21.32 | 15.12 | 141.04 |
| A:B=1:40 | 1.87 | 22.46 | 15.53 | 144.62 |
| A:B=1:30 | 1.65 | 25.45 | 16.21 | 157.02 |
| A:B=1:20 | 1.59 | 26.42 | 17.54 | 150.59 |
| A:B=1:10 | 1.26 | 33.33 | 21.29 | 156.57 |
| A:B=1:1 | 0.45 | 93.33 | 56.71 | 164.58 |
| A:B=10:1 | 0.29 | 144.83 | 92.13 | 157.20 |
| A:B=20:1 | 0.31 | 135.48 | 95.88 | 141.31 |
| A:B=30:1 | 0.32 | 131.25 | 97.21 | 135.02 |
| A:B=40:1 | 0.33 | 127.27 | 97.89 | 130.02 |
| A:B=50:1 | 0.32 | 131.25 | 98.30 | 133.52 |
| A:B=60:1 | 0.34 | 123.53 | 98.58 | 125.31 |
| A:B=70:1 | 0.42 | 100.00 | 98.78 | 101.23 |
Toxicity Determination result shows：Tetrazolium pyrrole urethane and methoxy acrylic bactericide SYP-3375, famoxadones,
Fenamidone is using weight ratio as 1：80~60：1 mixed has synergistic effect to the late blight of potato.
In order to which the present invention is better described, present invention is described further with reference to embodiment, in formula
Percentage is weight percentage.
Example of formulations 1
Weigh 30% tetrazolium pyrrole urethane, 15% SYP-3375,5% alkylphenol-polyethenoxy base ether phosphate, 4% alkylnaphthalene sulfonate first
Aldehyde condensate, 5% lauryl sodium sulfate, kaolin are filled up to 100% parts by weight.Above-mentioned raw materials are blended, ultra micro air-flow powder
Broken, hybrid technique step is prepared into 45% tetrazolium pyrrole urethane SYP-3375 wettable powder.
Example of formulations 2
Weigh 25% tetrazolium pyrrole urethane, 10% famoxadone, 4% alkyl naphthalene formaldehyde condensation product sodium sulfonate, 7% alkylnaphthalene sulfonate formaldehyde
Condensation product, 8% alkylnaphthalene sulfonate, white carbon are filled up to 100% parts by weight.Above-mentioned raw materials are blended, ultra micro air-flow crushing, mixed
Close processing step and be prepared into 35% tetrazolium pyrrole An Zhi famoxadone wettable powders.
Example of formulations 3
Weigh 15% tetrazolium pyrrole urethane, 10% Fenamidone, 5% polycarboxylate TERSPERSE 2700,4% dispersing agent NNO（Alkylnaphthalene
Sulfonate and formaldehyde condensation product）, 4% Nekal BX（Nekal）, 4% neopelex, attapulgite adds to
100% parts by weight.The method of the frequent regulation water intaking dispersible granule of above-mentioned raw materials is mixing, ultra micro air-flow crushing, mixing, granulation step
Suddenly 25% tetrazolium pyrrole urethane Fenamidone water dispersible granules are produced.
Example of formulations 4
Weigh 25% tetrazolium pyrrole urethane, 15% famoxadone, 5% polycarboxylate T36,6% sodium lignin sulfonate, 4% Nekal BX（Two
Sodium butylnaphthalenesulfonate）、1.5%K-12（Lauryl sodium sulfate）, 1% polyethylene glycol, 2% starch, fine particle calcium carbonate adds to 100% parts by weight.
Method i.e. mixing, ultra micro air-flow crushing, mixing, the granulation step of the frequent regulation water intaking dispersible granule of above-mentioned raw materials produces 40% 4
Azoles pyrrole An Zhi famoxadone water dispersible granules.
Example of formulations 5
Weigh 20% tetrazolium pyrrole urethane, 10% SYP-3375,5% sodium lignin sulfonate, 5% sodium naphthalene sulfonate, 6% sodium alkyl sulfate, 2% silicon
Sour magnalium, 0.3% polyvinyl alcohol, 4% propane diols, 0.1% potassium sorbate, 1% hexanol, deionized water add to 100% parts by weight.It is above-mentioned
Raw material is blended, and high speed shear disperses 30min, is sanded with sand mill to particle diameter D9030% tetrazolium pyrrole ammonia is made after less than 10 μm
Ester SYP-3375 suspending agent.
Example of formulations 6
Weigh 12% tetrazolium pyrrole urethane, 8% famoxadone, 7% polycarboxylate, 4% phenethyl phenol polyoxyethylene groups ether phosphate, 4% alkane
Base sodium sulphate, 0.6% carboxymethyl cellulose, 3% glycerine, 0.1% formaldehyde, 1% butanol, deionized water add to 100% parts by weight.On
It is blended to state raw material, high speed shear disperses 30min, is sanded with sand mill to particle diameter D9020% tetrazolium pyrrole ammonia is made after less than 10 μm
Zhi famoxadone suspending agents.
Example of formulations 7
Weigh 15% tetrazolium pyrrole urethane, 10% Fenamidone, 4% sodium lignin sulfonate, 8% sodium naphthalene sulfonate, 3% Negel,
0.3% carboxymethyl cellulose, 0.3% bentonite, 4% propane diols, 0.15% sodium benzoate, 1% hexanol, deionized water add to 100% weight
Measure part.Above-mentioned raw materials are blended, and high speed shear disperses 30min, are sanded with sand mill to particle diameter D9025% 4 is made after less than 10 μm
Azoles pyrrole urethane Fenamidone suspending agent.
Example of formulations 8
Weigh 10% tetrazolium pyrrole urethane, 10% SYP-3375,5% 3 phenethyl phenol polyoxyethylene ether phosphate, 3% dispersing agent NNO,
4% dispersant TERSPERSE4894,6% castor oil, 4% methyl oleate, 3% this disk -60#, 4% Tween-60 #, 1% dispersant
TERSPERSE 2500,2% aluminium-magnesium silicate, 0.3% xanthans, 5% ethylene glycol, 1% epoxychloropropane, 0.3% benzoic acid, 0.5% have
Machine silicon defoaming agent S-29, deionized water add to 100% parts by weight.Above-mentioned raw materials are well mixed, and high speed shear disperses 30min, uses sand
20% tetrazolium pyrrole urethane SYP-3375 suspension emulsion is made after being sanded in grinding machine.
Example of formulations 9
Weigh 15% tetrazolium pyrrole urethane, 5% famoxadone, 2% dispersing agent NNO, 3% dispersant TERSPERSE2425,8% oleic acid first
Ester, 8% soybean oil, 4% agriculture breast 1601#, 4% Tween-60 #, 3% this disk -60#, 2% alkylphenol-polyethenoxy base ether phosphate, 2% gather
Vinyl alcohol, 0.2% xanthans, 5% ethylene glycol, 3% triphenyl phosphite, 0.2% sodium benzoate, 0.5% organic silicon defoamer s-29,
Deionized water adds to 100% parts by weight.Above-mentioned raw materials are well mixed, and high speed shear disperses 30min, are made after being sanded with sand mill
20% tetrazolium pyrrole An Zhi famoxadone suspension emulsions.
Example of formulations 10
Weigh 10% tetrazolium pyrrole urethane, 15% Fenamidone, 5% agriculture breast TX-10#, 4% Nongru-700 #, 8% agriculture breast 2201#, 2% this disk-
60#, 1% epoxidized soybean oil, 2% ethylene glycol, 5% dimethylbenzene, 0.4% bentonite, 0.4% sodium benzoate, deionized water add to 100% weight
Measure part.Above-mentioned raw materials are blended, and 25% tetrazolium pyrrole urethane Fenamidone aqueous emulsion is made in high speed shearing emulsification.
Example of formulations 11
Weigh 15% tetrazolium pyrrole urethane, 10% SYP-3375,6% agriculture breast 2201#, 4% triphenoethyl benzene phenol polyethenoxy ether phosphate,
1% Tween-60 #, 5% this disk -60#, 5% propane diols, 8% toluene, 5% cyclohexanone, 0.15% xanthans, 0.3% formaldehyde, deionized water
Add to 100% parts by weight.Above-mentioned raw materials are blended, and 25% tetrazolium pyrrole urethane SYP-3375 aqueous emulsion is made in high speed shearing emulsification.
Example of formulations 12
Weigh 20% tetrazolium pyrrole urethane, 5% famoxadone, 5% agriculture breast 400#, 6% agriculture breast 1601#, 8% cyclohexanone, 4% cyclohexanone, 5%
Isopropanol, through dissolving completely and being well mixed, deionized water adds to 100% parts by weight, and 25% tetrazolium pyrrole urethane is made after stirring
Famoxadone microemulsion.
Example of formulations 13
Weigh 15% tetrazolium pyrrole urethane, 10% Fenamidone, 8%TX-10,5% agriculture breast 500#, 6% Nongru-700 #, 5% dimethylbenzene, 5% first
Benzene, 6% octanol, through dissolving completely and being well mixed, deionized water adds to 100% parts by weight, and 25% tetrazolium pyrrole ammonia is made after stirring
Ester Fenamidone microemulsion.
Example of formulations 14
Weigh 25% tetrazolium pyrrole urethane, 5% SYP-3375,6% sodium alginate, 6% aliphatic alcohol polyethenoxy base ether, 8% fatty acid ester,
4% benzyl dimethyl phenol polyoxyethyl ether, 12% sodium hydroxide and sorbic acid, 1% hexanol, deionized water add to 100% parts by weight.Will
Active component, macromolecule cyst material, solvent are mixed into homogeneous oil phase, and oil phase is added in aqueous phase solution, after shearing is scattered
30% tetrazolium pyrrole urethane SYP-3375 microcapsule suspending agent is made after solidification.
Example of formulations 15
Weigh 10% tetrazolium pyrrole urethane, 15% famoxadone, 6% Arabic gum, 5% alkyl benzene calcium sulfonate, 6% linseed oil, 4% benzyl two
Sylvan polyoxyethyl ether, 3% sodium hydroxide and hydrochloric acid, 1% organic silicon defoamer, deionized water add to 100% parts by weight.Will be living
Property composition, macromolecule cyst material, solvent be mixed into homogeneous oil phase, oil phase is added in aqueous phase solution, it is solid after shearing is scattered
25% tetrazolium pyrrole An Zhi famoxadone microcapsule suspending agents are made after change.
Example of formulations 16
Weigh 20% tetrazolium pyrrole urethane, 10% Fenamidone, 8% urea, 5% formaldehyde, 10% castor oil polyoxyethylene ether, 5% aliphatic acid
Polyoxyethylene ester, 2% lauryl sodium sulfate, 4% propane diols, 1% methylcellulose, 0.6% butanol, deionized water supply surplus.
Urea and formaldehyde are added in the reactor with frequency control, the pH value of solution is adjusted to 7.5~8.5 with sodium hydroxide solution
Left and right, 55~70 DEG C are then heated to, react the urea resin prepolymer stablized.A certain amount of Fenamidone is taken to be dissolved in molten
In agent, it is added to the water after addition emulsifier for mixing is uniform, under high shear homogeneous, is made into the stable breast of the types of O/W containing emulsifying dispersant
Liquid.Above-mentioned urea resin prepolymer is added in emulsion, pH value is adjusted, polymerisation occurs under acid catalysed conditions, makes oil
Phase material is wrapped, and forms microcapsule granule.Slowly heating, solidification, temperature control at 45~55 DEG C, hardening time 1~
1.5h, dispersant is added, microcapsule suspending agent containing Fenamidone is first made；Tetrazolium pyrrole urethane and water and other auxiliary agents are being reacted
After kettle shearing uniformly, it is sanded in sand mill, makes suspending agent particle diameter D90 below 5 μm, can be made into the urethane of pyrrole containing tetrazolium
Suspending agent.The suspending agent of the urethane of pyrrole containing tetrazolium and the micro-capsule suspension containing Fenamidone are mixed evenly in proportion, i.e.,
It can be made into 30% tetrazolium pyrrole urethane Fenamidone microcapsule suspension-suspendinagent agent.
Example of formulations 17
Weigh 15% tetrazolium pyrrole urethane, 10% SYP-3375,6% urea, 8% formaldehyde, 12% sorbitan monostearate, 6% fat
Amine APEO, 4% neopelex, 3% glycerine, 1.5% xanthans, 0.5% octanol, deionized water are supplied remaining
Amount.According to the processing method of example of formulations 16, you can 25% tetrazolium pyrrole urethane SYP-3375 microcapsule suspension-suspendinagent agent is made.
Example of formulations 18
Weigh 20% tetrazolium pyrrole urethane, 15% famoxadone, 5% polycarboxylic acids sodium, 8% Tween-60 #, 5%BY-125,3% sodium naphthalene sulfonate,
1% bentonite, 3% ethylene glycol, soybean oil add to 100% parts by weight.Above-mentioned raw materials are blended, and high speed shear disperses 30min, uses sand
Grinding machine makes the 35% dispersible oil-suspending agent of tetrazolium pyrrole An Zhi famoxadones after being sanded.
Example of formulations 19
Weigh 5% tetrazolium pyrrole urethane, 20% Fenamidone, 5% Negel, 4%BY-140,6% Tween-60 #, 5% agriculture breast
2201#, 3% APES phosphate, 3% aluminium-magnesium silicate, 5% bentonite, small wheat oil add to 100% parts by weight.It is above-mentioned
Raw material is blended, and high speed shear disperses 30min, and it is dispersible that 25% tetrazolium pyrrole urethane Fenamidone is made after being sanded with sand mill
Oil-suspending agent.
Example of formulations 20
Weigh 15% tetrazolium pyrrole urethane, 10% SYP-3375,6% dioctyl sodium sulphosuccinate, 5% neopelex, 5%
Sodium sulphate, 5% carboxymethyl cellulose, 2% hexanol, white carbon add to 100% parts by weight.Above-mentioned slurry carries out wet method powder with sand mill
It is broken that suspension slurry is made, spray drying granulation is then carried out, 25% tetrazolium pyrrole urethane is made by sieving in the particle after granulation
SYP-3375 dry suspending agent.
Example of formulations 21
Weigh 10% tetrazolium pyrrole urethane, 15% famoxadone, 8% neopelex, 6% AEO, 4% poly-
Vinyl alcohol, 2% polyethylene glycol, 5% butanol, precipitated calcium carbonate add to 100% parts by weight.Above-mentioned slurry carries out wet method powder with sand mill
It is broken that suspension slurry is made, spray drying granulation is then carried out, 25% tetrazolium pyrrole urethane is made by sieving in the particle after granulation
Famoxadone dry suspending agent.
Biological Examples 1：Prevent and treat cucumber downy mildew field test.
Example of formulations 5 has been carried out in Shouguang City of Shandong Province within 2017（30% tetrazolium pyrrole urethane SYP-3375 suspending agent）、
Example of formulations 6（20% tetrazolium pyrrole An Zhi famoxadones suspending agent), example of formulations 7（25% tetrazolium pyrrole urethane imidazoles bacterium
Ketone suspending agent) preventing and treating cucumber downy mildew field test, the medicament is demonstrated to the prevention effect of cucumber downy mildew and to cucumber
Security.
Trial crops are cucumber, and controlling object is cucumber downy mildew（Pseudoperonospora cubensis）.Experiment
Shouguang City rice field Zhen Dong rice fields village is located at, experimental plot physical features is flat, and soil is loam, middle fertility, pH value 6.9, during experiment
Rich water quality management is medium.Test medicine and dosage refer to table 7.Blank control separately is set, often handles 4 repetitions, per cell 30 ㎡, totally 32
Individual cell, random district's groups arrangement.Using conventional spray-on process, mu dispenser liquid 45kg, leave dual sides are uniformly sprayed at.
Investigation and statistical method：State of an illness radix is investigated before dispenser, 10~14d is reinvestigated once after last time dispenser, altogether
Investigation 2 times.Take at random per cell at 4 points, investigate 2 plants, and every plant of whole blades of investigation, every leaf accounts for leaf area according to scab at every
Percentage classification record.Stage division：
0 grade：Disease-free spot；
1 grade：Lesion area accounts for less than the 5% of whole leaf area；
3 grades：Lesion area accounts for the 6%~10% of whole leaf area；
5 grades：Lesion area accounts for the 11%~25% of whole leaf area；
7 grades：Lesion area accounts for the 26%~50% of whole leaf area；
9 grades：Lesion area accounts for more than the 50% of whole leaf area.
Disease index=[∑ (the sick numbers of sheets at different levels × relative value of series)/(investigation total leaf number × 9)] × 100
Prevention effect (%)=[1- (disease index after disease index × processing dispenser before control dispenser)/（The state of an illness refers to after control dispenser
Disease index before number × processing dispenser] × 100
Table 7 prevents and treats cucumber downy mildew field test results
Table of field test results is bright, and 3 embodiments of the above have good prevention effect to cucumber downy mildew, by the medication in upper table
Amount spraying 2 times, reaches more than 94%, hence it is evident that better than the preventive effect of each single dose to the preventive effect of cucumber downy mildew.By to cucumber downy mildew
Sick preventive effect significance difference analysis, difference reach the pole level of signifiance.
Security survey to cucumber, observed within some days after the 1st day and medicine after spray, each test process is to cucumber without poisoning
Phenomenon occurs.
Biological Examples 2：Prevent and treat epidemic disease field test.
In July, 2017 has carried out example of formulations 5 in Fugu County of Shaanxi Province（30% tetrazolium pyrrole urethane SYP-3375 suspends
Agent）, example of formulations 6（20% tetrazolium pyrrole An Zhi famoxadones suspending agent), example of formulations 7（25% tetrazolium pyrrole urethane miaow
Cycloheximide triazole suspending agent) preventing and treating late blight of potato field test.Plot of the test arrangement in morbidity over the years again, starts to occur July
Incidence of leaf, test medicine and extension rate are shown in Table 8, separately set blank control, often handle 4 repetitions, per the ㎡ of plot area 25, altogether
32 cells, random district's groups arrangement.Using conventional spray-on process, blade positive and negative uniformly squirt, liter/mu of decoction dosage 50.In disease
First time dispenser when evil just occurs, second of dispenser after 14d, dispenser is twice altogether.
Investigation and statistical method：14d carries out disease index investigation after second of dispenser, per the 5 points of samplings of cell diagonal,
Every is investigated 3 plants, is investigated whole blades, record total number of sheets, the sick number of sheets at different levels and sick series, is calculated disease index.
Grade scale is:
0 grade, disease-free spot；
1 grade, lesion area accounts for less than the 5% of whole leaf area；
3 grades, lesion area accounts for the 6%~10% of whole leaf area；
5 grades, lesion area accounts for the 11%~20% of whole leaf area；
7 grades, lesion area accounts for the 21%~50% of whole leaf area；
9 grades, lesion area accounts for more than the 50% of whole leaf area.
Disease index and prevention effect computational methods：
Disease index=Σ（The sick numbers of sheets at different levels × relative value of series）/（Investigate total number of sheets × 9）×100
Prevention effect（%）=[（Disease index after disease index-chemicals treatment district dispenser after blank district dispenser）/ blank pair
According to disease index after area's dispenser] × 100
Table 8 prevents and treats late blight of potato field test results
Table of field test results is bright, and 4 embodiments of the above have good prevention effect to the late blight of potato, by the use in upper table
Dose is sprayed 2 times, reaches more than 95% to the preventive effect of the late blight of potato, hence it is evident that better than the preventive effect of each single dose.By to Ma Ling
Potato late blight preventive effect significance difference analysis, difference reach the pole level of signifiance.
Security survey to potato, observed within some days after the 1st day and medicine after spray, each test process to potato without
Poisoning phenomenon occurs.
Above example illustrates that the first active component tetrazolium pyrrole urethane is killed with the second active component methoxy acrylic
It is a kind of by weight 1 in microbial inoculum SYP-3375, famoxadones, Fenamidone：80~60：1 compounding, can be made into wettable powder
Agent, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent, dispersible oil
Suspending agent, dry suspension formulation, have significant prevention effect, synergistic effect is obvious, and dosage is few, anti-to crop downy mildew, epidemic disease
Effect height is controlled, and it is good to crop safety.
In summary, composition of the invention is to use two kinds of active components compound scheme, and its activity and bactericidal effect are not
It is the simple superposition of each component activity, compared with existing unitary agent, in addition to significant bactericidal effect, more has significantly
Synergistic effect, security is good to making, and meets the security requirement of pesticidal preparations.
Claims (4)
1. a kind of bactericidal composition of the urethane of pyrrole containing tetrazolium, it is characterised in that active ingredient is by the first active component tetrazolium pyrrole ammonia
A kind of composition in ester and the second active component methoxy acrylic bactericide SYP-3375, famoxadones, Fenamidone,
The weight of first active component and the second active component ratio is 1：80~60：1.
2. the bactericidal composition of the urethane of pyrrole containing tetrazolium according to claim 1, it is characterised in that the first active component and second
The weight ratio of active component is 1：60~40：1.
3. the bactericidal composition contained according to claim 1, it is characterised in that the combination dosage form is wettable powder, water
Dispersible granule, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent, dispersible oil suspend
Agent, dry suspension.
4. purposes of the bactericidal composition of the urethane of pyrrole containing tetrazolium in preventing and treating crop downy mildew, epidemic disease according to claim 1.
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| CN201710660469.1A CN107347900A (en) | 2017-08-04 | 2017-08-04 | A kind of bactericidal composition of the urethane of pyrrole containing tetrazolium |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110301450A (en) * | 2018-03-20 | 2019-10-08 | 江苏龙灯化学有限公司 | Tetrazolium pyrrole urethane is reducing or preventing the purposes in crop disease |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106922698A (en) * | 2015-12-30 | 2017-07-07 | 江苏龙灯化学有限公司 | A kind of bactericidal composition |
| CN106922710A (en) * | 2015-12-29 | 2017-07-07 | 浙江新农化工股份有限公司 | Compositions of the picarbutrazox with mitochondrial cytochrome enzyme inhibitor series bactericidal agent and its preparation and application |
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2017
- 2017-08-04 CN CN201710660469.1A patent/CN107347900A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106922710A (en) * | 2015-12-29 | 2017-07-07 | 浙江新农化工股份有限公司 | Compositions of the picarbutrazox with mitochondrial cytochrome enzyme inhibitor series bactericidal agent and its preparation and application |
| CN106922698A (en) * | 2015-12-30 | 2017-07-07 | 江苏龙灯化学有限公司 | A kind of bactericidal composition |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110301450A (en) * | 2018-03-20 | 2019-10-08 | 江苏龙灯化学有限公司 | Tetrazolium pyrrole urethane is reducing or preventing the purposes in crop disease |
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Application publication date: 20171117 |