CN107343873B - Cleaning liquid for relieving hydrofluoric acid burn and preparation method thereof - Google Patents
Cleaning liquid for relieving hydrofluoric acid burn and preparation method thereof Download PDFInfo
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- CN107343873B CN107343873B CN201610307562.XA CN201610307562A CN107343873B CN 107343873 B CN107343873 B CN 107343873B CN 201610307562 A CN201610307562 A CN 201610307562A CN 107343873 B CN107343873 B CN 107343873B
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- hydrofluoric acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Abstract
The invention relates to a cleaning solution for relieving hydrofluoric acid burn, which is characterized by comprising the following components: creatine-calcium gluconate, sodium chloride and water. The cleaning solution for relieving hydrofluoric acid burn can effectively reduce the toxic effect of hydrogen ions and fluorine ions on human bodies by utilizing components such as creatine-calcium gluconate and the like; has the functions of relieving local pain and diminishing inflammation, can quickly treat hydrofluoric acid injury accidents at the first site of the accident, and is beneficial to the later treatment of the wound.
Description
Technical Field
The invention relates to a treatment solution for hydrofluoric acid burn accidents, in particular to a cleaning solution for relieving hydrofluoric acid burn and a preparation method thereof.
Background
Hydrofluoric acid is an important industrial raw material and has important application in the aspects of semiconductor etching, glass etching, metal rust removal, petroleum refining, leather making, printing and dyeing, manufacturing of various fluorine-containing fine chemicals and the like, but hydrofluoric acid is a highly toxic chemical substance and can cause serious burns, poisoning and even death through contacting with skin, respiratory tract, mucous membrane, gastrointestinal tract and the like. Poisoning cases of hydrofluoric acid (or anhydrous hydrogen fluoride) are reported from time to time, and although a traditional on-site emergency treatment method of hydrofluoric acid has a certain effect, the effect is not ideal, so that a new on-site emergency treatment scheme needs to be researched according to the characteristic that the hydrofluoric acid is harmful to human bodies, and the harm degree of the hydrofluoric acid to the human bodies is reduced.
The mechanism of the injury of hydrofluoric acid to human body is as follows:
HF→H++F□
(1) local corrosion and dehydration similar to strong acids are caused by hydrogen ions.
(2) Fluorine is one of the most active nonmetallic elements and binds strongly to hydrogen ions (ionization constant K3.5 × 10 □ 4). After the skin is contacted with hydrofluoric acid, the non-ionic HF is continuously dissociated and permeates into deep tissues to dissolve cell membranes, so that liquefaction and necrosis of epidermis, dermis, subcutaneous tissues and muscular layers are caused. Fluoride ions combine with calcium and magnesium ions in the tissue to form poorly soluble salts, such as CaF2, Ca5F (PO4)3, causing depletion of calcium and magnesium ions in the body, resulting in hypocalcemia, hypomagnesemia, arrhythmia, convulsions, and even death. The decrease of calcium ion increases the permeability of cell membrane to potassium ion, and potassium ion causes depolarization of nerve cell from inside to outside of cell to cause severe pain.
The routes of hydrofluoric acid poisoning include skin contact, inhalation, ingestion, eye exposure, etc., with concentrations less than 20%, and may be delayed until 24 hours to become symptomatic; concentrations of between 20% and 50%, usually exhibiting toxic symptoms within hours; at concentrations above 50%, immediate pain and significant tissue damage occurred.
The degree of skin damage is related to the concentration of hydrofluoric acid, the contact time, the contact site and the treatment method. The higher the concentration, the longer the contact time, the more rapid and intense the action. Subcutaneous tissue necrosis is severe, and the dense tissue part of the finger is severely painful.
Pain and skin damage often occur immediately upon exposure to hydrofluoric acid at concentrations above 30%. When the skin is contacted with low concentration, pain and skin burn occur often after several hours, the local skin lesion is initially red spot, then turns into white edema with red halo, then turns into light green gray necrosis, then becomes dark brown or black thick scab, and the ulcer is formed after the scab is removed. The lesions of the finger are necrosis of the subcutaneous tissue, grayish brown or black, periungual swelling, formation of fluid accumulation under the nail in severe cases, separation of nail bed from nail plate, and nail floating.
High-concentration burns often show progressive necrosis, ulcer healing is slow, severe cases involve bones, particularly bones, and the symptoms are aseptic osteomyelitis.
Hydrofluoric acid mist can cause skin itching and dermatitis, and in large doses can also cause burns to the skin, gastrointestinal and respiratory mucosa.
Local symptoms of hydrofluoric acid poisoning include sore and sore oropharynx, burns, nausea, vomiting, abdominal pain, hematemesis, severe bleeding of stomach and esophagus, perforation, etc.; systemic symptoms include dizziness, lassitude, convulsions, agitation, confusion, coma, arrhythmia, and even cardiac arrest. A minimum of 1.5mg of hydrofluoric acid taken orally will result in death.
Due to the rapid permeability of fluoride ions to subcutaneous tissues, time is of great significance for the field treatment of hydrofluoric acid poisoning, and the traditional treatment method for poisoning caused by skin exposure is to firstly wash the skin for 15-30 minutes with tap water, then paint calcium gluconate emulsion and then treat the skin by professional medical staff, but although the measures are adopted, serious injury cannot be avoided.
Disclosure of Invention
In view of the above, it is necessary to provide a cleaning solution for relieving hydrofluoric acid burn which is more effective in relieving hydrofluoric acid burn and cleaning hydrofluoric acid, in view of the above-mentioned problems such as the above-mentioned damage to the human body due to the contact of hydrofluoric acid with the skin by industrial, laboratory, etc.
A cleaning solution for relieving hydrofluoric acid burn comprises the following components: an active ingredient, sodium chloride, and water; the active ingredient is selected from creatine-calcium gluconate or creatine-calcium citrate.
The cleaning solution for relieving hydrofluoric acid burn can effectively reduce the toxic effect of hydrogen ions and fluorine ions on human bodies by utilizing components such as creatine-calcium gluconate or calcium gluconate; has the functions of relieving local pain and diminishing inflammation, can quickly treat hydrofluoric acid injury accidents at the first site of the accident, and is beneficial to the later treatment of the wound.
In one embodiment, the weight ratio of the active ingredient to the sodium chloride is 1-50: 5-15.
In one embodiment, the weight ratio of the active ingredient to the sodium chloride is 5-10: 5-15.
In one preferred embodiment, the cleaning solution for relieving hydrofluoric acid burn further comprises less than 1 part by weight of nano titanium dioxide.
In one preferable embodiment, the pH value of the cleaning liquid is 6-8.
In one preferred embodiment, the pH of the cleaning solution is 7.
A preparation method of a cleaning solution for relieving hydrofluoric acid burn comprises the following steps:
adding creatine-calcium gluconate or creatine-calcium citrate into normal saline to obtain a first mixed solution;
and adding dilute hydrochloric acid into the first mixed solution until the pH value of the first mixed solution is adjusted to be within the range of 6-8.
In one preferred embodiment, the concentration of the dilute hydrochloric acid is 0.1 mol/L.
A preparation method of a cleaning solution for relieving hydrofluoric acid burn comprises the following steps:
mixing creatine-gluconic acid or creatine-citric acid, calcium hydroxide and normal saline to obtain a second mixed solution;
and adding dilute hydrochloric acid into the second mixed solution until the pH value of the second mixed solution is adjusted to be within the range of 6-8.
In one preferred embodiment, the concentration of the dilute hydrochloric acid is 0.1 mol/L.
The cleaning liquid for relieving hydrofluoric acid burn prepared by the method utilizes components such as creatine-calcium gluconate or calcium gluconate to effectively reduce the toxic corrosion of hydrogen ions and fluorine ions to human bodies; has the functions of relieving local pain and diminishing inflammation, can quickly treat hydrofluoric acid injury accidents at the first site of the accident, and is beneficial to the later treatment of the wound.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The invention discloses a cleaning solution for relieving hydrofluoric acid burn, which comprises the following components in parts by weight: the creatine-calcium gluconate preparation comprises 1-50 parts by weight of creatine-calcium gluconate and 5-15 parts by weight of sodium chloride, and preferably, the weight part of the creatine-calcium gluconate preparation can be 5-10 parts.
The cleaning solution for relieving hydrofluoric acid burn can also comprise a trace amount of nano titanium dioxide, for example 1 wt% of nano titanium dioxide.
The cleaning solution for relieving hydrofluoric acid burn is neutral, namely the pH value is in the range of 6-8, and the preferred pH value is 7.
The cleaning solution for relieving hydrofluoric acid burn can effectively reduce the toxic effect of hydrogen ions and fluorine ions on human bodies by utilizing components such as creatine-calcium gluconate and the like; has effects of relieving local pain and diminishing inflammation, can rapidly treat hydrofluoric acid injury accident at the first site of accident, and is beneficial to post-treatment of wound
The second preferred embodiment of the invention discloses another cleaning solution for relieving hydrofluoric acid burn, which comprises the following components: the creatine-calcium citrate is 1-50 parts by weight, and the sodium chloride is 5-15 parts by weight, and more preferably, the creatine-calcium citrate may be 5-10 parts by weight.
The cleaning solution for relieving hydrofluoric acid burn can also comprise a trace amount of nano titanium dioxide, for example 1 wt% of nano titanium dioxide.
The cleaning solution for relieving hydrofluoric acid burn is neutral, namely the pH value is in the range of 6-8, and the preferred pH value is 7.
The cleaning solution for relieving hydrofluoric acid burn can effectively reduce the toxic effect of hydrogen ions and fluorine ions on human bodies by utilizing components such as creatine-calcium citrate and the like; has effects of relieving local pain and diminishing inflammation, can rapidly treat hydrofluoric acid injury accident at the first site of accident, and is beneficial to post-treatment of wound
The third preferred embodiment of the invention discloses a third cleaning solution for relieving hydrofluoric acid burn, which comprises the following components: the creatine-calcium gluconate preparation comprises creatine-calcium gluconate, creatine-calcium citrate and sodium chloride, wherein the total weight of the creatine-calcium citrate and the creatine-calcium gluconate is 1-50 parts by weight, the weight of the sodium chloride is 5-15 parts by weight, and more preferably, the total weight of the creatine-calcium citrate and the creatine-calcium gluconate can be 5-10 parts by weight.
The cleaning solution for relieving hydrofluoric acid burn can also comprise a trace amount of nano titanium dioxide, for example, 1 part by weight of nano titanium dioxide.
The cleaning solution for relieving hydrofluoric acid burn can effectively reduce the toxic effect of hydrogen ions and fluorine ions on human bodies by utilizing the components of creatine-calcium gluconate, creatine-calcium citrate and the like; has the functions of relieving local pain and diminishing inflammation, can quickly treat hydrofluoric acid injury accidents at the first site of the accident, and is beneficial to the later treatment of the wound.
The fourth preferred embodiment of the invention discloses a preparation method of a cleaning solution for relieving hydrofluoric acid burn, which specifically comprises the following steps:
s1: adding creatine-calcium gluconate or creatine-calcium citrate into normal saline to obtain a first mixed solution;
s2: and adding dilute hydrochloric acid into the first mixed solution until the pH value of the first mixed solution is adjusted to be within the range of 6-8.
Preferably, the concentration of the dilute hydrochloric acid in this embodiment is 0.1 mol/L.
The cleaning liquid for relieving hydrofluoric acid burn prepared by the method can effectively reduce the toxic effect of hydrogen ions and fluorine ions on human bodies by utilizing the components such as creatine-calcium gluconate or creatine-calcium citrate in the cleaning liquid for relieving hydrofluoric acid burn; has the functions of relieving local pain and diminishing inflammation, can quickly treat hydrofluoric acid injury accidents at the first site of the accident, and is beneficial to the later treatment of the wound.
The fifth preferred embodiment of the invention discloses a preparation method of a cleaning solution for relieving hydrofluoric acid burn, which specifically comprises the following steps:
s1: mixing creatine-gluconic acid or creatine-citric acid and calcium hydroxide with normal saline to obtain a second mixed solution;
s2: and adding dilute hydrochloric acid into the second mixed solution until the pH value of the second mixed solution is adjusted to be within the range of 6-8.
Preferably, the concentration of the dilute hydrochloric acid in this embodiment is 0.1 mol/L.
The cleaning liquid for relieving hydrofluoric acid burn prepared by the method can effectively reduce the toxic effect of hydrogen ions and fluorine ions on human bodies by utilizing the components such as creatine-calcium gluconate or creatine-calcium citrate in the cleaning liquid for relieving hydrofluoric acid burn; has effects of relieving local pain and diminishing inflammation, can rapidly treat hydrofluoric acid injury accident at the first site of accident, and is beneficial to post-treatment of wound
The above embodiments of the present invention are further illustrated below with reference to specific examples.
Example 1
The cleaning solution A1 for relieving hydrofluoric acid burn had the following composition:
0.5-1.0 g of creatine calcium gluconate;
94-95 g of 0.9-1% normal saline
Example 2
The cleaning solution A2 for relieving hydrofluoric acid burn had the following composition:
0.5-1.0 g of creatine calcium citrate;
94-95 g of 0.9-1% normal saline
The affected parts of 5 hydrofluoric acid patients were cleaned with cleaning solution A1, the affected parts of another 5 hydrofluoric acid patients were cleaned with cleaning solution A2, and the affected parts of still another 5 hydrofluoric acid patients were smeared with calcium gluconate emulsion. Collecting the information after the patient uses. The experimental results prove that: compared with a patient coated with the calcium gluconate emulsion, the patient A1-A2 is cleaned by the cleaning solution, so that the pain feeling is less, the recovery is quicker, and the scab is smaller, which shows that the cleaning solution can effectively reduce the toxic corrosion of hydrofluoric acid to the human body.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. The cleaning solution for relieving hydrofluoric acid burn is characterized by comprising the following components: active ingredient, sodium chloride and water; the active ingredient is selected from creatine-calcium gluconate or creatine-calcium citrate.
2. The cleaning solution for relieving hydrofluoric acid burn according to claim 1, wherein the weight ratio of the active ingredient to the sodium chloride is 1-50: 5-15.
3. The cleaning solution for relieving hydrofluoric acid burn according to claim 2, wherein the weight ratio of the active ingredient to the sodium chloride is 5-10: 5-15.
4. The cleaning solution for relieving hydrofluoric acid burn according to any one of claims 1-3, wherein the cleaning solution further comprises nano titanium dioxide, and the content of the nano titanium dioxide is less than 1 wt%.
5. The cleaning solution for relieving hydrofluoric acid burn according to claim 1, wherein the pH value of the cleaning solution is 6-8.
6. The cleaning solution for alleviating hydrofluoric acid burn of claim 5 wherein the pH of the cleaning solution is 7.
7. A preparation method of a cleaning solution for relieving hydrofluoric acid burn is characterized by comprising the following steps:
adding creatine-calcium gluconate or creatine-calcium citrate into normal saline to obtain a first mixed solution;
and adding dilute hydrochloric acid into the first mixed solution until the pH value of the first mixed solution is adjusted to be within the range of 6-8.
8. The method for preparing a cleaning solution for relieving hydrofluoric acid burn according to claim 7, wherein the concentration of the dilute hydrochloric acid is 0.1 mol/L.
9. A preparation method of a cleaning solution for relieving hydrofluoric acid burn is characterized by comprising the following steps:
mixing creatine-gluconic acid or creatine-citric acid with calcium hydroxide in normal saline to obtain a second mixed solution;
and adding dilute hydrochloric acid into the second mixed solution until the pH value of the second mixed solution is adjusted to be within the range of 6-8.
10. The method for preparing a cleaning solution for relieving hydrofluoric acid burn according to claim 9, wherein the concentration of the dilute hydrochloric acid is 0.1 mol/L.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610307562.XA CN107343873B (en) | 2016-05-05 | 2016-05-05 | Cleaning liquid for relieving hydrofluoric acid burn and preparation method thereof |
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| CN201610307562.XA CN107343873B (en) | 2016-05-05 | 2016-05-05 | Cleaning liquid for relieving hydrofluoric acid burn and preparation method thereof |
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| CN107343873A CN107343873A (en) | 2017-11-14 |
| CN107343873B true CN107343873B (en) | 2020-09-01 |
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| CN110151782A (en) * | 2019-06-19 | 2019-08-23 | 天津市恒兴化学试剂制造有限公司 | It is a kind of for alleviating the cleaning solution of hydrofluoric acid burn |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102824639A (en) * | 2011-06-13 | 2012-12-19 | 张家港市亚源高新技术材料有限公司 | Emergency solution used for relieving burn of hydrofluoric acid |
| CN105079030A (en) * | 2014-05-08 | 2015-11-25 | 重庆市化工研究院 | Decontamination liquid for protecting human bodies from being burned by chemical substances |
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| WO2005117852A1 (en) * | 2004-06-01 | 2005-12-15 | Cameco Corporation | Composition for treatment of a hydrofluoric acid burn |
| FR2987269B1 (en) * | 2012-02-27 | 2014-04-18 | Hopitaux Paris Assist Publique | GELIFYING FORMULATION BASED ON CALCIUM GLUCONATE |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102824639A (en) * | 2011-06-13 | 2012-12-19 | 张家港市亚源高新技术材料有限公司 | Emergency solution used for relieving burn of hydrofluoric acid |
| CN105079030A (en) * | 2014-05-08 | 2015-11-25 | 重庆市化工研究院 | Decontamination liquid for protecting human bodies from being burned by chemical substances |
Non-Patent Citations (1)
| Title |
|---|
| 区域性静脉灌注葡萄糖酸钙治疗足部氢氟酸烧伤患者的护理;张建芬等;《护理学杂志》;20130625;第28卷(第12期);第20-21页 * |
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