CN107334815A - A kind of pharmaceutical composition for treating cranial vascular disease and preparation method thereof - Google Patents
A kind of pharmaceutical composition for treating cranial vascular disease and preparation method thereof Download PDFInfo
- Publication number
- CN107334815A CN107334815A CN201710604712.8A CN201710604712A CN107334815A CN 107334815 A CN107334815 A CN 107334815A CN 201710604712 A CN201710604712 A CN 201710604712A CN 107334815 A CN107334815 A CN 107334815A
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- pharmaceutical composition
- bulk drug
- leech
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 48
- 208000019553 vascular disease Diseases 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 239000003814 drug Substances 0.000 claims abstract description 54
- 229940079593 drug Drugs 0.000 claims abstract description 47
- 241000545744 Hirudinea Species 0.000 claims abstract description 26
- 238000000034 method Methods 0.000 claims abstract description 20
- 241000361919 Metaphire sieboldi Species 0.000 claims abstract description 18
- 240000007164 Salvia officinalis Species 0.000 claims abstract description 15
- 235000005412 red sage Nutrition 0.000 claims abstract description 15
- 230000008569 process Effects 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 239000000706 filtrate Substances 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims description 9
- 235000017491 Bambusa tulda Nutrition 0.000 claims description 9
- 241000258920 Chilopoda Species 0.000 claims description 9
- 241000521581 Millettia Species 0.000 claims description 9
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims description 9
- 241001522129 Pinellia Species 0.000 claims description 9
- 235000006040 Prunus persica var persica Nutrition 0.000 claims description 9
- 241000923606 Schistes Species 0.000 claims description 9
- 239000011425 bamboo Substances 0.000 claims description 9
- 229910001919 chlorite Inorganic materials 0.000 claims description 9
- 229910052619 chlorite group Inorganic materials 0.000 claims description 9
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 claims description 9
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 9
- 244000144730 Amygdalus persica Species 0.000 claims description 8
- 244000020518 Carthamus tinctorius Species 0.000 claims description 7
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims description 7
- 241000427159 Achyranthes Species 0.000 claims description 6
- 239000009636 Huang Qi Substances 0.000 claims description 6
- 244000205574 Acorus calamus Species 0.000 claims description 5
- 235000011996 Calamus deerratus Nutrition 0.000 claims description 5
- 241000931705 Cicada Species 0.000 claims description 5
- 230000024241 parasitism Effects 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 244000037364 Cinnamomum aromaticum Species 0.000 claims description 4
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000000243 solution Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 244000082204 Phyllostachys viridis Species 0.000 claims 2
- 235000006463 Brassica alba Nutrition 0.000 claims 1
- 244000140786 Brassica hirta Species 0.000 claims 1
- 235000011371 Brassica hirta Nutrition 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 14
- 208000026106 cerebrovascular disease Diseases 0.000 abstract description 11
- 206010008118 cerebral infarction Diseases 0.000 abstract description 9
- 206010008111 Cerebral haemorrhage Diseases 0.000 abstract description 8
- 210000004556 brain Anatomy 0.000 abstract description 8
- 238000011031 large-scale manufacturing process Methods 0.000 abstract description 2
- 239000008280 blood Substances 0.000 description 36
- 210000004369 blood Anatomy 0.000 description 36
- 210000004185 liver Anatomy 0.000 description 22
- 230000000694 effects Effects 0.000 description 21
- 230000017531 blood circulation Effects 0.000 description 20
- 206010062717 Increased upper airway secretion Diseases 0.000 description 17
- 208000026435 phlegm Diseases 0.000 description 17
- 238000011282 treatment Methods 0.000 description 15
- 239000000796 flavoring agent Substances 0.000 description 14
- 235000019634 flavors Nutrition 0.000 description 14
- 230000001737 promoting effect Effects 0.000 description 13
- 208000006011 Stroke Diseases 0.000 description 10
- 210000000952 spleen Anatomy 0.000 description 10
- 206010008190 Cerebrovascular accident Diseases 0.000 description 9
- 235000009508 confectionery Nutrition 0.000 description 9
- 208000002193 Pain Diseases 0.000 description 8
- 208000002173 dizziness Diseases 0.000 description 8
- 230000036407 pain Effects 0.000 description 8
- 241001330002 Bambuseae Species 0.000 description 7
- 210000004072 lung Anatomy 0.000 description 7
- 238000005728 strengthening Methods 0.000 description 7
- 210000003734 kidney Anatomy 0.000 description 6
- 230000001151 other effect Effects 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- 230000000202 analgesic effect Effects 0.000 description 5
- 210000003205 muscle Anatomy 0.000 description 5
- 208000004929 Facial Paralysis Diseases 0.000 description 4
- 208000036826 VIIth nerve paralysis Diseases 0.000 description 4
- 210000000988 bone and bone Anatomy 0.000 description 4
- 210000003414 extremity Anatomy 0.000 description 4
- 238000009499 grossing Methods 0.000 description 4
- 210000003141 lower extremity Anatomy 0.000 description 4
- 210000000582 semen Anatomy 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 210000003932 urinary bladder Anatomy 0.000 description 4
- 206010001928 Amenorrhoea Diseases 0.000 description 3
- 244000025254 Cannabis sativa Species 0.000 description 3
- 206010013887 Dysarthria Diseases 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 3
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 3
- 210000001367 artery Anatomy 0.000 description 3
- 230000036770 blood supply Effects 0.000 description 3
- 230000000747 cardiac effect Effects 0.000 description 3
- 230000002490 cerebral effect Effects 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 206010022437 insomnia Diseases 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 208000026473 slurred speech Diseases 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 201000001320 Atherosclerosis Diseases 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 206010021118 Hypotonia Diseases 0.000 description 2
- 206010039424 Salivary hypersecretion Diseases 0.000 description 2
- 208000003028 Stuttering Diseases 0.000 description 2
- 230000001093 anti-cancer Effects 0.000 description 2
- 230000001663 anti-spastic effect Effects 0.000 description 2
- 201000007201 aphasia Diseases 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 208000017561 flaccidity Diseases 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 210000000629 knee joint Anatomy 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000001114 myogenic effect Effects 0.000 description 2
- 231100000862 numbness Toxicity 0.000 description 2
- 230000007096 poisonous effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000011321 prophylaxis Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 208000026451 salivation Diseases 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 244000001632 Acorus gramineus Species 0.000 description 1
- 235000013073 Acorus gramineus Nutrition 0.000 description 1
- 241000242759 Actiniaria Species 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 241000208365 Celastraceae Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 208000019505 Deglutition disease Diseases 0.000 description 1
- 235000014066 European mistletoe Nutrition 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001484259 Lacuna Species 0.000 description 1
- 208000028389 Nerve injury Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 240000005809 Prunus persica Species 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010061926 Purulence Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 244000152640 Rhipsalis cassutha Species 0.000 description 1
- 235000012300 Rhipsalis cassutha Nutrition 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 241000522620 Scorpio Species 0.000 description 1
- 235000000336 Solanum dulcamara Nutrition 0.000 description 1
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000009748 deglutition Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002475 laxative effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 230000008764 nerve damage Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 210000004129 prosencephalon Anatomy 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000009490 scorpio Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
- 235000021286 stilbenes Nutrition 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/648—Myriapods, e.g. centipedes or millipedes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Insects & Arthropods (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of pharmaceutical composition for treating cranial vascular disease and preparation method thereof, it is related to field of medicaments.The pharmaceutical composition includes the first bulk drug, and the first bulk drug includes：The bush of 14 16 parts by weight；The red sage root of 14 16 parts by weight；The leech of 46 parts by weight；The earthworm of 9 12 parts by weight；And 69 parts by weight process naze, effectively treat or prevent the diseases such as cerebral infarction, cerebral hemorrhage brain, and prevent because above-mentioned illness causes complications or sequelae.The preparation method of aforementioned pharmaceutical compositions is to mix the first raw material medicaments in part by weight number, crushes, decoction at least 20 minutes is mixed with water, obtains filtrate, and this method is simply controllable, easy to operation, and large-scale production can be achieved.
Description
Technical field
The present invention relates to field of medicaments, and more particularly to a kind of pharmaceutical composition for treating cranial vascular disease and its preparation side
Method.
Background technology
The cranial vascular diseases such as existing some treatment cerebral infarction, cerebral hemorrhages, and prevent because above-mentioned cranial vascular disease causes disease hair
The medicine and method of disease or sequelae, aphasia from apoplexy etc., have deficiency, it is impossible to reach the effect treated both principal and secondary aspect of disease.
The content of the invention
It is an object of the invention to provide a kind of pharmaceutical composition for treating cranial vascular disease, has qi and activate blood circulation, by the stasis of blood
Dredging collateral, phlegm reduction of blood circulation promoting, ceases wind reduce blood fat and other effects, effectively treat or prevent the diseases such as cerebral infarction, cerebral hemorrhage, and prevent because above-mentioned
Illness causes complications or sequelae.
Another object of the present invention is to the preparation method for the pharmaceutical composition for providing above-mentioned treatment cranial vascular disease, operation
Simply, it is controllable, quickly obtain finished product.
The present invention is solved its technical problem and realized using following technical scheme.
The present invention proposes a kind of pharmaceutical composition for treating cranial vascular disease, and it includes the first bulk drug, the first bulk drug
Including：The bush of 14-16 parts by weight；The red sage root of 14-16 parts by weight；The leech of 4-6 parts by weight；The earthworm of 9-12 parts by weight；With
And 6-9 parts by weight process naze.
The present invention proposes a kind of preparation method of aforementioned pharmaceutical compositions, the first raw material medicaments in part by weight number is mixed, powder
It is broken, decoction at least 20 minutes is mixed with water, obtains filtrate.
The beneficial effect of the pharmaceutical composition for the treatment of cranial vascular disease of the embodiment of the present invention and preparation method thereof is：
By the rational proportion between each drug component, each herbal medicine synergy, have qi and activate blood circulation, by blood stasis and smoothing collaterals,
The functions such as phlegm reduction of blood circulation promoting, ceases wind reduction blood fat, fundamentally effectively treat cranial vascular disease, especially treat and prevent cerebral infarction,
The diseases such as cerebral hemorrhage brain, vascular atherosclerosis and cerebral thrombus, and prevent the pain caused by above-mentioned illness, headache, insomnia, dizzy
Complications or the sequelae such as dizzy, cardiac and cerebral blood supply insufficiency.
The preparation method is simply controllable, easy to operation, and large-scale production can be achieved.
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical scheme be clearly and completely described.Unreceipted actual conditions person, builds according to normal condition or manufacturer in embodiment
The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, it is the conventional production that can be obtained by commercially available purchase
Product.
Have below to a kind of pharmaceutical composition for treating cranial vascular disease of the embodiment of the present invention and preparation method thereof
Body explanation.
The present invention provides a kind of pharmaceutical composition for treating cranial vascular disease, and it includes the first bulk drug, wherein, first is former
Material medicine includes：The bush of 14-16 parts by weight；The red sage root of 14-16 parts by weight；The leech of 4-6 parts by weight；The ground of 9-12 parts by weight
Dragon；And 6-9 parts by weight process naze, by the reasonable compatibility of each component in the first bulk drug, each herbal medicine synergy, tool
There is qi and activate blood circulation, reduce the functions such as blood fat by blood stasis and smoothing collaterals, phlegm reduction of blood circulation promoting, ceases wind, effectively treat cranial vascular disease, especially treat
With the disease such as prevention cerebral infarction, cerebral hemorrhage brain, vascular atherosclerosis and cerebral thrombus, and prevent the pain caused by above-mentioned illness,
Complications or the sequelae such as headache, insomnia, dizziness, cardiac and cerebral blood supply insufficiency.
Wherein, bush, nature and flavor：It is sweet, salty, put down, thoughts of returning home warp, Liver Channel, the spleen channel, there is promoting circulation of blood, broken stasis of blood, detumescence, the work(of analgesic
Effect.The red sage root, nature and flavor：Bitter, it is slightly cold, the thoughts of returning home, Liver Channel, there is promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness that clears away heart-fire, the work(of cool blood to disappear carbuncle
Effect.Leech, taste is salty, puts down, and enter liver, bladder two pass through, and has treatment apoplexy, hypertension, the clear stasis of blood, amenorrhoea, traumatic injury and other effects, closely
Year new discovery leech preparation has special efficacy in preventing and treating cranial vascular disease and anticancer aspect.Earthworm, nature and flavor：Taste is salty；It is cold in nature, Return liver,
Spleen, bladder warp, have a heat-clearing, soothing the liver, Zhichuan, the effect of dredging collateral, promoting blood circulation and removing blood stasis, prophylactic treatment cranial vascular disease.Naze is processed, is had
There is detumescence to suppurate, scattered silt dredging collateral, stimulate the menstrual flow, lower breast, invigorating blood circulation analgesia.Ulcer sore swells are controlled, wind-cold-dampness arthralgia, Amenorrhea, alactation, are stopped
Blood, disease scab gather the effect of.
It is highly preferred that the first bulk drug includes：The bush of 15 parts by weight；The red sage root of 15 parts by weight；The leech of 6 parts by weight；
The earthworm of 10 parts by weight；And 8 parts by weight process naze, under the conditions of this ratio, qi and activate blood circulation, by blood stasis and smoothing collaterals, phlegm reduction of blood circulation promoting, breath
Wind reduces the functional effects such as blood fat more preferably.
Because cranial vascular disease is often with general weakness, it is preferred that the first bulk drug also includes the Huang of 4-6 parts by weight
Stilbene, effectively treat or alleviate powerless while effectively treating cranial vascular disease.It is highly preferred that the first bulk drug also includes 5 weight
The Radix Astragali of part, effective invigorating qi for strengthening superficies, myogenic.Wherein, the Radix Astragali, nature and flavor：It is sweet, temperature, return lung, the spleen channel, there is invigorating qi for strengthening superficies, eliminating toxic row
Purulence, diuresis, the effect of myogenic.
Preferably, the first bulk drug also includes the root of bidentate achyranthes of 4-6 parts by weight, the parasitism of 7-8 parts by weight, effectively remove obstruction in channels to relieve pain,
Scattered blood stasis, strengthening the bones and muscles, effectively enhancing treatment or the symptom of alleviation soreness of waist and knee joint and flaccidity and weakness of the lower limbs, with remaining component reasonable compatibility
Nourishing liver kidney, strengthening the bones and muscles etc., effectively treatment or alleviate the lower limb symptom such as again.It is highly preferred that the first bulk drug includes posting for 7 parts by weight
It is raw, and the root of bidentate achyranthes of 5 parts by weight, treat or the symptom of alleviation soreness of waist and knee joint and flaccidity and weakness of the lower limbs is better.Wherein, the root of bidentate achyranthes,
Nature and flavor：Hardship, acid, put down, enter liver and kidney channel, there is filling liver kidney, strengthening the bones and muscles, the effect of invigorate blood circulation.Parasitism is Chinese medicine mistletoe
Alias, it is bitter in taste；It is sweet；It is mild-natured, Return liver；Kidney channel, have and control filling liver kidney；Strengthening the bones and muscles；The effect of wind-damp dispelling.
Preferably, the first bulk drug also includes the earthworm of 8-11 parts by weight, the calamus of 11-13 parts by weight, 9-11 parts by weight
Bombys batryticatus, the cicada slough of 9-11 parts by weight, and the semen brassicae of 9-11 parts by weight, effectively treatment or alleviate because cranial vascular disease is led
Situations such as slurred speech of cause, apoplexy.
Wherein, the traditional Chinese medical science thinks that the slurred speech that apoplexy and apoplexy trigger is due to that qi and blood is inverse disorderly, produce wind, fire, phlegm,
The stasis of blood, cause to cause brains nerve damage outside the resistance of brain vessle-Bi symptom-complex or the excessive brain arteries and veins of blood and fall ill.And earthworm, nature and flavor：Taste is salty；It is cold in nature, return
Liver, spleen, bladder warp, have a heat-clearing, soothing the liver, Zhichuan, the effect of dredging collateral, promoting blood circulation and removing blood stasis, prophylactic treatment cranial vascular disease.Herein
Calamus can be Rhizoma Anemones Altaicae, grass-leaved sweetflag or rhizoma calami, be respectively provided with the effect of reducing phlegm by resuscitation, a surname's gas are by phlegm.Bombys batryticatus, it is the other of stiff silkworm
Claim, nature and flavor：It is salty, pungent, put down, Return liver, lung, stomach, can expel endogenous wind to relieve convulsion, reducing phlegm and resolving masses.Cicada slough, sweet, salty, cool in nature, return lung, liver
Through there is dispelling wind and heat from the body, relieving sore-throat opens sound, the effect of Inflammation Zhijing.Semen brassicae is warm-natured, and rich gas is sharp, enters lung, stomach, can sharp gas
Slit phlegm, warming spleen and stomach for dispelling cold, remove obstruction in channels to relieve pain.By the cooperation of above-mentioned each component, effective sharp gas slit phlegm, dispelling wind and heat from the body, promoting blood circulation and removing blood stasis, change
Phlegm dissipating bind etc., coordinate with remaining component, effectively treatment or alleviation is due to the feelings such as slurred speech, apoplexy caused by cranial vascular disease
Condition.
It is highly preferred that the first bulk drug also includes the earthworm of 10 parts by weight, the calamus of 12 parts by weight, the bombys batryticatus of 10 parts by weight
The cicada slough of 10 parts by weight, and the semen brassicae of 10 parts by weight, sharp gas slit phlegm, dispelling wind and heat from the body, promoting blood circulation and removing blood stasis, reducing phlegm and resolving masses and other effects
More preferably.
Preferably, the first bulk drug also includes the cassia seed of 9-11 parts by weight, it is highly preferred that the first bulk drug also includes 10
The cassia seed of parts by weight, effectively alleviate or treat dizzy caused by heart and brain blood backbone's disease.Wherein, cassia seed bitter, it is sweet,
It is salty, cold nature, enter liver, kidney, large intestine channel；Relax bowel, clear liver and improve vision, sharp water defaecation, there is laxative action, reducing blood pressure and blood fat.
In order to further enhance the therapeutic effect of pharmaceutical composition, it is preferable that pharmaceutical composition also includes the second bulk drug,
Specifically, the second bulk drug includes：The Radix Angelicae Sinensis of 14-16 parts by weight；The full worm of 9-10 parts by weight；The peach kernel of 9-11 parts by weight；9-
The safflower of 11 parts by weight；The leech of 7-8 parts by weight；The centipede of 3-5 parts by weight；The dried orange peel of 9-10 parts by weight；11-13 parts by weight
The tuber of pinellia；The blue or green chlorite schist of 28-32 parts by weight, the Tabasheer of 17-20 parts by weight；The bamboo juice of 17-20 parts by weight；14-16 parts by weight
Reticulate millettia.Further effective promoting blood circulation, blood stasis removing analgesic, dredging collateral, dissipating bind, further enhance therapeutic effect.
Wherein, Radix Angelicae Sinensis, nature and flavor：Sweet, acrid, warm, Return liver, the heart, the spleen channel, there is replenishing and activating blood, menstruction regulating and pain relieving, relax bowel
Effect.Full worm, also known as scorpio, nature and flavor：It is pungent, put down；Poisonous, return liver warp has antispastic cramp and relieves dizziness, anti-inflammatory and attacked poison, the work(removed obstruction in channels to relieve pain
Effect.Peach kernel, nature and flavor：Bitter sweet, put down, nontoxic, the thoughts of returning home, liver, large intestine, lung, the spleen channel, there is the effect of blood-breaking row stasis of blood, moisturize laxation.It is red
Flower, warm-natured, acrid flavour, invigorate blood circulation, blood stasis removing analgesic.Leech, taste is salty, puts down, and enter liver, bladder two pass through, and has treatment apoplexy, high blood
Pressure, the clear stasis of blood, amenorrhoea, traumatic injury and other effects, in recent years new discovery leech preparation preventing and treating cranial vascular disease and anticancer aspect have
Special efficacy.Centipede, nature and flavor：It is pungent, temperature；It is poisonous；Return liver warp, there is ceases wind antispastic, dispersing pathogen accumulation, the effect of removing obstruction in channels to relieve pain.Dried orange peel, property
Taste：It is arduous, temperature, enter spleen, lung channel, there is the effect of regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm；The tuber of pinellia, there is blood stasis removing analgesic；Removing toxicity for detumescence
Effect.Blue or green chlorite schist, property is sweet, salty, flat, falls gas under phlegm.Tabasheer, nature and flavor：It is sweet, tremble with fear, thoughts of returning home warp, Liver Channel, there is dispelling wind and eliminating dampness, work
The effect of easypro warp of blood, cough-relieving.Bamboo juice, it is sweet in flavor and cold in property, the fire for the lung stomach that can clear away heart-fire, there is slit phlegm to moisturize, the effect of arresting convulsion.Reticulate millettia, property
Taste：Hardship, micro-sweet；It is warm-natured.The thoughts of returning home, the spleen channel, dissipate gas, promoting blood circulation, relaxing muscles and tendons, active and other effects.
It is highly preferred that the second bulk drug includes：The Radix Angelicae Sinensis of 15 parts by weight；The full worm of 10 parts by weight；The peach kernel of 10 parts by weight；
The safflower of 10 parts by weight；The leech of 8 parts by weight；The centipede of 5 parts by weight；The dried orange peel of 10 parts by weight；The tuber of pinellia of 12 parts by weight；30 weights
Measure the blue or green chlorite schist of part, the Tabasheer of 18 parts by weight；The bamboo juice of 18 parts by weight；The reticulate millettia of 15 parts by weight.Further effectively invigorate blood circulation,
Blood stasis removing analgesic, dredging collateral, dissipating bind, further enhance therapeutic effect.
Preferably, the formulation of pharmaceutical composition is decoction, oral solutions, granule, pill, powder, syrup or capsule
Any one in agent.For example, the formulation of pharmaceutical composition is decoction, or pill, it can also be capsule.
The present invention also provides the preparation method of aforementioned pharmaceutical compositions, and the first bulk drug is mixed, and crushes, and mixes and decocts with water
Boil at least 20 minutes, obtain filtrate.
When aforementioned pharmaceutical compositions contain the second raw material, first the second raw materials by weight portion of raw material is mixed, crushed,
Decoction at least 20 minutes is mixed with water, obtains filtrate.
Wherein, the preferred mesh sieve of mistake 20 after above-mentioned crushing, then screenings is decocted at least 20 minutes, such as 30 minutes, 50 points
Clock, 60 minutes etc., obtain filtrate.
Preferably, screenings is mixed with water, after soaking 20-40 minutes, then decocted, when being easy to save follow-up decoct
Between.Wherein, decocting once to be carried out, and can also be carried out step by step, for example, decocting for the first time, filtered, obtained the first filtrate and first
Filter residue, the first filter residue continue to decoct, and obtain the second filtrate, merge the first filtrate and the second filtrate etc., are not specifically limited herein.
The feature and performance of the present invention are described in further detail with reference to embodiments.
Embodiment 1
A kind of pharmaceutical composition for treating cranial vascular disease, it is prepared by following methods：
First bulk drug is mixed, crushed, decoction 40 minutes is mixed with water, obtains filtrate.
Wherein, the first bulk drug includes：The bush of 15 parts by weight；The red sage root of 15 parts by weight；The leech of 6 parts by weight；10 weights
Measure the earthworm of part；And 8 parts by weight process naze.
Embodiment 2
A kind of pharmaceutical composition for treating cranial vascular disease, it is prepared by following methods：
First bulk drug is mixed, crushed, decoction 20 minutes is mixed with water, obtains filtrate.
Wherein, the first bulk drug includes：The bush of 14 parts by weight；The red sage root of 16 parts by weight；The leech of 6 parts by weight；9 weight
The earthworm of part；The Radix Astragali of 5 parts by weight；And 8 parts by weight process naze.
Embodiment 3
A kind of pharmaceutical composition for treating cranial vascular disease, after it is mixed by the first raw material, according to existing technology and
Equipment is made as granule.
Wherein, the first bulk drug includes：The bush of 16 parts by weight；The red sage root of 14 parts by weight；The leech of 4 parts by weight；12 weights
Measure the earthworm of part；The root of bidentate achyranthes of 5 parts by weight, the parasitism of 8 parts by weight；And 7 parts by weight process naze.
Embodiment 4
A kind of pharmaceutical composition for treating cranial vascular disease, it is made as by the first raw material according to existing technology and equipment
Pill.
Wherein, the first bulk drug includes：The bush of 15 parts by weight；The red sage root of 15 parts by weight；The leech of 5 parts by weight；20 weights
Measure the earthworm of part；The calamus of 12 parts by weight, the bombys batryticatus of 10 parts by weight, the cicada slough of 10 parts by weight, the semen brassicae of 10 parts by weight, and
8 parts by weight process naze.
Embodiment 5
A kind of pharmaceutical composition for treating cranial vascular disease, it is prepared by following methods：
First bulk drug is mixed with the second bulk drug, crushed, decoction 50 minutes is mixed with water, obtains filtrate.
Wherein, the first bulk drug includes：The bush of 15 parts by weight；The red sage root of 15 parts by weight；The leech of 6 parts by weight；10 weights
Measure the earthworm of part；And 8 parts by weight process naze.
Second bulk drug includes：The Radix Angelicae Sinensis of 15 parts by weight；The full worm of 10 parts by weight；The peach kernel of 10 parts by weight；10 parts by weight
Safflower；The leech of 8 parts by weight；The centipede of 5 parts by weight；The dried orange peel of 10 parts by weight；The tuber of pinellia of 12 parts by weight；The green grass or young crops of 30 parts by weight
Chlorite schist, the Tabasheer of 18 parts by weight；The bamboo juice of 18 parts by weight；And 15 parts by weight reticulate millettia.
Embodiment 6
A kind of pharmaceutical composition for treating cranial vascular disease, after it is mixed by the first raw material and the second raw material, according to existing
Technology and equipment be made as pill.
First bulk drug includes：The bush of 15 parts by weight；The red sage root of 15 parts by weight；The leech of 5 parts by weight；10 parts by weight
Earthworm；The root of bidentate achyranthes of 5 parts by weight；The parasitism of 7 parts by weight；And 8 parts by weight process naze.
Second bulk drug includes：The Radix Angelicae Sinensis of 14 parts by weight；The full worm of 9 parts by weight；The peach kernel of 9 parts by weight；9 parts by weight it is red
Flower；The leech of 7 parts by weight；The centipede of 3 parts by weight；The dried orange peel of 9 parts by weight；The tuber of pinellia of 11 parts by weight；The blue or green chlorite schist of 28 parts by weight,
The Tabasheer of 17 parts by weight；The bamboo juice of 17 parts by weight；And 14 parts by weight reticulate millettia.
Embodiment 7
A kind of pharmaceutical composition for treating cranial vascular disease, after it is mixed by the first raw material and the second raw material, according to existing
Technology and equipment be made as powder.
First bulk drug includes：The red sage root of the parts by weight of bush 15 of 15 parts by weight；The leech of 5 parts by weight；10 parts by weight
Earthworm；The Radix Astragali of 6 parts by weight；And 9 parts by weight process naze.
Second bulk drug includes：The Radix Angelicae Sinensis of 16 parts by weight；The full worm of 10 parts by weight；The peach kernel of 11 parts by weight；11 parts by weight
Safflower；The leech of 8 parts by weight；The centipede of 5 parts by weight；The dried orange peel of 10 parts by weight；The tuber of pinellia of 13 parts by weight；The green grass or young crops of 32 parts by weight
Chlorite schist, the Tabasheer of 18 parts by weight；The bamboo juice of 20 parts by weight；And 16 parts by weight reticulate millettia.
Embodiment 8
A kind of pharmaceutical composition for treating cranial vascular disease, its mixed by the first raw material and the second raw material after according to existing
Technology and equipment are made as oral solutions.
First bulk drug includes：The bush of 16 parts by weight；The red sage root of 14 parts by weight；The leech of 6 parts by weight；11 parts by weight
Earthworm；The Radix Astragali of 6 parts by weight；And 8 parts by weight process naze.
Second bulk drug includes：The Radix Angelicae Sinensis of 15 parts by weight；The full worm of 10 parts by weight；The peach kernel of 10 parts by weight；11 parts by weight
Safflower；The leech of 7 parts by weight；The centipede of 3 parts by weight；The dried orange peel of 10 parts by weight；The tuber of pinellia of 11 parts by weight；The green grass or young crops of 29 parts by weight
Chlorite schist, the Tabasheer of 18 parts by weight；The bamboo juice of 18 parts by weight；And 15 parts by weight reticulate millettia.
Test example
Embodiment 1-8 is repeated, the pharmaceutical composition of enough treatment cranial vascular diseases is made.Started successively in 2016
(men and women is than 1 by patient 50 of the selection with cranial vascular disease：1), using treatment cerebrovascular disease made from 1-8 of the embodiment of the present invention
The pharmaceutical composition of disease, wherein, the pharmaceutical composition that embodiment 1-8 is provided is daily three times.
Empirical tests, 76% patient is 1 month after the pharmaceutical composition for the treatment of cranial vascular disease provided by the invention is taken
Afterwards, cerebral infarction, cerebral hemorrhage and its complication etc. improve, and 85% patient is averagely taking treatment cerebrovascular disease provided by the invention
After 2.5 months, cerebral infarction, cerebral hemorrhage and its complication etc. are obviously improved or cured the pharmaceutical composition of disease.It is exemplified below 2 tools
Body patient is described in detail：
1. Mr. Wang, female.
Extremity numbness is felt, is had a dizzy spell suddenly when afternoon nap is got up, mind is still clear, and gradual left hand acts ineffective, ability to speak
Unclear, right side facial paralysis, tongue can not be stretched, mouth salivation, dysphagia, aphasia from apoplexy, blood pressure 190/90mmHg.Be admitted to hospital examine for：Lacuna
Property cerebral infarction.
Tcm diagnosis is stroke in convalescent stage, card category Qi deficiency blood stasis type, is taken after pharmaceutical composition provided by the invention 1 month
Look is slightly shaken afterwards, and salivation is reduced, and facial paralysis tongue improves by force, and can prevaricate half language, and function of deglutition recovers.After dosage slightly increases and decreases, continue
Take to second month, tongue is secretly significantly improved, and all diseases are calmed down.
2. certain, male slowly.
2 years hemorrhages of forebrain, through rescuing Survive the perils of life, but it is stuttering to leave the strong language of tongue, facial paralysis, left limb paralysis,
Multi-treatment DeGrain.Existing bicker right avertence, the strong language of tongue is stuttering, and left limb can not praise activity, dizzy weak, bicker stream
Saliva, extremity numbness, light purplish tongue tongue is thin white, and an arteries and veins left side is heavy, and the right side is heavy thin powerless, belongs to apoplexy sequelae, is Qi deficiency blood stasis type, takes
After one month, facial paralysis mitigates pharmaceutical composition provided by the invention, can answer simple question, left side upper and lower extremities can be raised
Moved from bed surface.After dosage slightly increases and decreases, continue with taking to after the 2.5th month, all disease disappearances, can out-of-bed activity, take care of oneself.
To sum up, pharmaceutical composition for the treatment of cranial vascular disease of the embodiment of the present invention and preparation method thereof, there is QI invigorating to live
Blood, by blood stasis and smoothing collaterals, phlegm reduction of blood circulation promoting, ceases wind blood fat and other effects is reduced, effectively treat or prevent cerebral infarction, cerebral hemorrhage brain, artery
The disease such as hardening and cerebral thrombus, and prevent pain, headache, insomnia, dizziness, cardiac and cerebral blood supply insufficiency etc. caused by above-mentioned illness
Complications or sequelae.
Embodiments described above is part of the embodiment of the present invention, rather than whole embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
- A kind of 1. pharmaceutical composition for treating cranial vascular disease, it is characterised in that described pharmaceutical composition includes the first bulk drug, First bulk drug includes：The bush of 14-16 parts by weight；The red sage root of 14-16 parts by weight；The leech of 4-6 parts by weight；9-12 weights Measure the earthworm of part；And 6-9 parts by weight process naze.
- 2. pharmaceutical composition according to claim 1, it is characterised in that first bulk drug includes：15 parts by weight The bush；The red sage root of 15 parts by weight；The leech of 6 parts by weight；The earthworm of 10 parts by weight；And 8 parts by weight Described process naze.
- 3. pharmaceutical composition according to claim 1, it is characterised in that first bulk drug also includes 4-6 parts by weight The Radix Astragali.
- 4. pharmaceutical composition according to claim 1, it is characterised in that first bulk drug also includes 4-6 parts by weight The root of bidentate achyranthes, the parasitism of 7-8 parts by weight.
- 5. pharmaceutical composition according to claim 1, it is characterised in that first bulk drug also includes 8-11 parts by weight Earthworm, the calamus of 11-13 parts by weight, the bombys batryticatus of 9-11 parts by weight, the cicada slough of 9-11 parts by weight, and 9-11 parts by weight is white Mustard seed.
- 6. pharmaceutical composition according to claim 1, it is characterised in that first bulk drug also includes 9-11 parts by weight Cassia seed.
- 7. pharmaceutical composition according to claim 1, it is characterised in that described pharmaceutical composition also includes the second raw material Medicine, second bulk drug include：The Radix Angelicae Sinensis of 14-16 parts by weight；The full worm of 9-10 parts by weight；The peach kernel of 9-11 parts by weight；9- The safflower of 11 parts by weight；The leech of 7-8 parts by weight；The centipede of 3-5 parts by weight；The dried orange peel of 9-10 parts by weight；11-13 parts by weight The tuber of pinellia；The blue or green chlorite schist of 28-32 parts by weight, the Tabasheer of 17-20 parts by weight；The bamboo juice of 17-20 parts by weight；14-16 parts by weight Reticulate millettia.
- 8. pharmaceutical composition according to claim 7, it is characterised in that second bulk drug includes：15 parts by weight The Radix Angelicae Sinensis；The full worm of 10 parts by weight；The peach kernel of 10 parts by weight；The safflower of 10 parts by weight；The institute of 8 parts by weight State leech；The centipede of 5 parts by weight；The dried orange peel of 10 parts by weight；The tuber of pinellia of 12 parts by weight；30 parts by weight it is described Blue or green chlorite schist, the Tabasheer of 18 parts by weight；The bamboo juice of 18 parts by weight；The reticulate millettia of 15 parts by weight.
- 9. according to the pharmaceutical composition described in claim 1-8 any one, it is characterised in that the formulation of described pharmaceutical composition For any one in decoction, oral solutions, granule, pill, powder, syrup or capsule.
- 10. the preparation method of pharmaceutical composition as claimed in claim 1, it is characterised in that first bulk drug is mixed, Crush, decoction at least 20 minutes is mixed with water, obtains filtrate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710604712.8A CN107334815A (en) | 2017-07-24 | 2017-07-24 | A kind of pharmaceutical composition for treating cranial vascular disease and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710604712.8A CN107334815A (en) | 2017-07-24 | 2017-07-24 | A kind of pharmaceutical composition for treating cranial vascular disease and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107334815A true CN107334815A (en) | 2017-11-10 |
Family
ID=60216479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710604712.8A Pending CN107334815A (en) | 2017-07-24 | 2017-07-24 | A kind of pharmaceutical composition for treating cranial vascular disease and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107334815A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114390927A (en) * | 2019-09-17 | 2022-04-22 | 鲁南制药集团股份有限公司 | New application of traditional Chinese medicine composition |
-
2017
- 2017-07-24 CN CN201710604712.8A patent/CN107334815A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114390927A (en) * | 2019-09-17 | 2022-04-22 | 鲁南制药集团股份有限公司 | New application of traditional Chinese medicine composition |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103432390A (en) | Medicament for treating coronary heart disease and preparation method thereof | |
| CN1288748A (en) | Medicine for treating cardiac and cerebral vascular diseases and its preparation | |
| CN104173773A (en) | Preparation with functions of treating migraine, dispelling wind and promoting blood circulation and preparation methods | |
| CN104173517A (en) | Traditional Chinese medicine preparation for treating primary trigeminal neuralgia and preparation methods | |
| CN107334815A (en) | A kind of pharmaceutical composition for treating cranial vascular disease and preparation method thereof | |
| CN104353051A (en) | Traditional Chinese medicine preparation for treating stomachache and preparation method thereof | |
| CN104800610A (en) | Traditional Chinese medicine preparation for treating Parkinson's disease and preparation method thereof | |
| CN104189587A (en) | Traditional Chinese medicine preparation capable of nourishing yin and suppressing excessive yang for treating epilepsy and preparation method of traditional Chinese medicine preparation | |
| CN104173775A (en) | Traditional Chinese medicine composition for treating cervicogenic headache and preparation method of traditional Chinese medicine composition | |
| CN104173676A (en) | Traditional Chinese medicinal preparation for treating epilepsy and preparation method thereof | |
| CN105106799A (en) | Prescription for treating ovarian cancer and preparation method | |
| CN105456951A (en) | Traditional Chinese medicine preparation for treating breast fibroadenoma and preparing method of traditional Chinese medicine preparation | |
| CN105079318A (en) | Blood-activating pain-relieving preparation for treating prosopalgia and preparation method | |
| CN104971262A (en) | Health porridge product for treating constipation and preparation method thereof | |
| CN104173815B (en) | Treat neurasthenic Chinese medicine composition and preparation method | |
| CN105055840A (en) | Drug for treating arrhythmia and preparation method thereof | |
| CN104800792A (en) | Traditional Chinese medicine preparation for treating reflux esophagitis and preparation method thereof | |
| CN104689205A (en) | Traditional Chinese preparation for treating insomnia and dreamful sleep and preparation method thereof | |
| CN104173685A (en) | Unguent for treating parotitis and preparation method thereof | |
| CN110755527A (en) | Medicine for treating early-stage kidney-yang deficiency stroke hemiplegia and preparation method thereof | |
| CN107638530A (en) | A kind of Chinese medicine composition for cervical spondylosis and preparation method thereof | |
| CN105147872A (en) | Traditional Chinese medicine composition mainly for treating cerebral infarction and preparation method thereof | |
| CN105963499A (en) | Traditional Chinese medicine composition for treating neuroses as well as preparation method and application thereof | |
| CN104840733A (en) | Traditional Chinese medicine preparation for treating anemia and preparation method of traditional Chinese medicine preparation | |
| CN105194312A (en) | Traditional Chinese medicine capsule for treating tinnitus cerebri with syndrome of qi depression transforming into fire and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171110 |