CN107334579A - A kind of Medical composite dressing - Google Patents
A kind of Medical composite dressing Download PDFInfo
- Publication number
- CN107334579A CN107334579A CN201710726229.7A CN201710726229A CN107334579A CN 107334579 A CN107334579 A CN 107334579A CN 201710726229 A CN201710726229 A CN 201710726229A CN 107334579 A CN107334579 A CN 107334579A
- Authority
- CN
- China
- Prior art keywords
- layer
- medical composite
- composite dressing
- dressing according
- honeycomb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002131 composite material Substances 0.000 title claims abstract description 19
- 239000010410 layer Substances 0.000 claims abstract description 87
- 239000003814 drug Substances 0.000 claims abstract description 29
- 239000002105 nanoparticle Substances 0.000 claims abstract description 12
- 239000004744 fabric Substances 0.000 claims abstract description 11
- 239000012790 adhesive layer Substances 0.000 claims abstract description 10
- 230000003115 biocidal effect Effects 0.000 claims abstract description 10
- 239000002121 nanofiber Substances 0.000 claims abstract description 9
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 8
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 14
- 239000000835 fiber Substances 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims description 10
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- -1 polyethylene Polymers 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 241001116389 Aloe Species 0.000 claims description 3
- 229920000742 Cotton Polymers 0.000 claims description 3
- 239000004425 Makrolon Substances 0.000 claims description 3
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 235000011399 aloe vera Nutrition 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000002985 plastic film Substances 0.000 claims description 3
- 229920006255 plastic film Polymers 0.000 claims description 3
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 3
- 229920000515 polycarbonate Polymers 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 239000004626 polylactic acid Substances 0.000 claims description 3
- 229920002635 polyurethane Polymers 0.000 claims description 3
- 239000004814 polyurethane Substances 0.000 claims description 3
- 235000004431 Linum usitatissimum Nutrition 0.000 claims description 2
- 239000004568 cement Substances 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 229920003023 plastic Polymers 0.000 claims description 2
- 240000006240 Linum usitatissimum Species 0.000 claims 1
- 240000007594 Oryza sativa Species 0.000 claims 1
- 235000007164 Oryza sativa Nutrition 0.000 claims 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 1
- 235000013339 cereals Nutrition 0.000 claims 1
- 235000009566 rice Nutrition 0.000 claims 1
- 238000002386 leaching Methods 0.000 abstract description 3
- 241000264877 Hippospongia communis Species 0.000 description 10
- 206010052428 Wound Diseases 0.000 description 7
- 208000027418 Wounds and injury Diseases 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 230000029663 wound healing Effects 0.000 description 5
- 238000001179 sorption measurement Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 210000000416 exudates and transudate Anatomy 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000013022 venting Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000208202 Linaceae Species 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000003578 releasing effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0203—Adhesive plasters or dressings having a fluid handling member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0246—Adhesive plasters or dressings characterised by the skin adhering layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0259—Adhesive plasters or dressings characterised by the release liner covering the skin adhering layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00289—Wound bandages easy removing of the protection sheet
Abstract
The present invention relates to a kind of Medical composite dressing, including waterproof layer, air-permeable layer, antibiotic layer, medicine layer and the adhesive layer set gradually from bottom to top, waterproof layer edge is connected with tab portion, tab portion substantially semicircular in shape, antibiotic layer includes fabric and the nano-particle being distributed in the fabric, medicine layer are made up of layers of nanofibers, medicine layer has honeycomb surface, honeycomb surface has honeycomb, and the surface of honeycomb is coated with hydrophobic layer, and adhesive layer distributes as net shape.The present invention is reasonable in design, and not only waterproof was again ventilative, and antibacterial effect is good, and leaching dose is high, changes conveniently.
Description
Technical field
The present invention relates to medical material fabric structure field, more particularly to a kind of Medical composite dressing.
Background technology
Covering of the medical dressing as wound, in wound healing process, impaired skin can be substituted and played temporarily
The barrier action of when property, avoid or control wound infection, there is provided be advantageous to the environment of wound healing.Nowadays, the city of medical dressing
Field value becomes more and more important, but also very prominent the shortcomings that its existing medical dressing:As dressing water resistance is poor, once enter
Water is, it is necessary to more change dressings, and frequently more change dressings is unfavorable for wound healing;Air permeable effect is bad so that comfortableness is not high;Medicine
Layer leaching dose is few, it is necessary to frequent more change dressings;, it is necessary to be taken off from skin surface during more change dressings, but existing dressing structure designs
It is unreasonable, cause with adhering skin too closely, during dressing pain and it is serious when can damage cambium.
The content of the invention
In order to solve the above technical problems, it is an object of the invention to provide a kind of Medical composite dressing, structure design of the present invention
Rationally, not only waterproof but also ventilative, and antibacterial effect is good, leaching dose is high, and it is convenient to change.
The present invention a kind of Medical composite dressing, including set gradually from bottom to top waterproof layer, air-permeable layer, antibiotic layer,
Medicine layer and adhesive layer, waterproof layer edge are connected with tab portion, tab portion substantially semicircular in shape, antibiotic layer include fabric with
And the nano-particle in fabric is distributed in, medicine layer is made up of nanofiber, and medicine layer has honeycomb surface, honeycomb surface
With honeycomb, the surface of honeycomb is coated with hydrophobic layer, and adhesive layer distributes as net shape.
Further, waterproof layer is made up of plastic film.
Further, plastic cement is aqueous polyurethane, polyethylene, PLA or makrolon.
Further, waterproof layer is translucent shape.Translucent waterproof layer is easy to the absorption sepage feelings of directly observation dressing
Condition.
Further, air-permeable layer includes fibrous layer and the activated carbon granule being distributed in the fibrous layer.Activated carbon
Grain is adhered in fibrous layer, will not be spilt, and activated carbon has profuse hole, has powerful adsorption capacity, Ke Yi great
The earth accelerates the adsorbance and adsorption rate of wound exudate, wound face is kept dry and comfortable in the state of being isolated from the outside, and improves
The venting capability of air-permeable layer.
Further, the material of fibrous layer is flax fiber layer, bamboo-carbon fibre or cotton fiber.
Further, fabric is formed by bamboo-carbon fibre and aloe fibre blending.
Further, nano-particle is the one or more in nano zine oxide, nano-Ag particles and nanogold particle.With
Upper nano-particle has antibacterial effect.
Further, it is impregnated with Chinese medicine in nanofiber.According to circumstances it can select to be impregnated with different treatment effects Chinese medicine
Dressing, accelerate wound healing or accelerate therapeutic effect.
By such scheme, the present invention at least has advantages below:
By setting waterproof layer, make dressing that there is waterproof effect, and the tab portion of waterproof layer connection, carried for the replacement of dressing
Convenience has been supplied, only tab portion need to have gently been pullled, dressing is quickly separated with skin, avoid traditional dressing and be bonded completely with skin
Afterwards, it is difficult to the defects of finding the point of penetration for opening dressing;The setting of air-permeable layer, ventilative work(is provided on the basis of water resistance
Can, improve comfort;There is antibiotic layer in dressing, greatly strengthen antibacterial effect, nano-particle plays main resist
Bacterium function;Medicine layer is made up of nanofiber, increases specific surface area, increases the drugloading rate of dressing, honey comb like surface is entered
One step improves the speed of insoluble drug release, and the setting of hydrophobic layer can prevent medicine from being infiltrated by wound exudate, and influence medicine
Releasing effect;Adhesive layer distributes as net shape so that dressing forms adhesive network face with skin, when an external force is applied, it is easy to
Dressing is separated with skin, avoids that cambium is caused to damage.
Described above is only the general introduction of technical solution of the present invention, in order to better understand the technological means of the present invention,
And can be practiced according to the content of specification, below with presently preferred embodiments of the present invention and coordinate accompanying drawing describe in detail as after.
Brief description of the drawings
Fig. 1 is the cross-sectional view of Medical composite dressing of the present invention;
Fig. 2 is the top view of Medical composite dressing of the present invention;
Fig. 3 is the structural representation of Medical composite dressing medicine layer of the present invention;
Fig. 4 is the enlarged drawing at Fig. 3 centre circles A;
Brief description of the drawings
1- waterproof layers;2- air-permeable layers;3- activated carbon granules;4- antibiotic layers;5- nano-particles;6- medicine layers;7- adhesive layers;
8- hydrophobic layers;11- tab portions.
Embodiment
With reference to the accompanying drawings and examples, the embodiment of the present invention is described in further detail.Implement below
Example is used to illustrate the present invention, but is not limited to the scope of the present invention.
Referring to Fig. 1-4, a kind of Medical composite dressing of the invention, including the waterproof layer 1, ventilative set gradually from bottom to top
Layer 2, antibiotic layer 4, medicine layer 6 and adhesive layer 7.
The edge of waterproof layer 1 is connected with tab portion 11, and waterproof layer 1 is made up of plastic film, optional aqueous polyurethane,
The one of which of polyethylene, PLA or makrolon, waterproof layer 1 are translucent shape.Translucent waterproof layer 1 is easy to directly see
Examine the absorption sepage situation of dressing.The material of tab portion 11 is identical with waterproof layer 1, the substantially semicircular in shape of tab portion 11.Tab portion 11
It is arranged on a vertex of waterproof layer 1.
Air-permeable layer 2 includes fibrous layer and uniform adhesion the activated carbon granule 3 in fibrous layer.The material of fibrous layer is Asia
Flaxen fiber layer, bamboo-carbon fibre or cotton fiber.Activated carbon granule 3 is adhered in fibrous layer, will not be spilt, and activated carbon is with extremely rich
Rich hole, has powerful adsorption capacity, can greatly speed up the adsorbance and adsorption rate of wound exudate, make wound
Face keeps dry and comfortable in the state of being isolated from the outside, and improves the venting capability of air-permeable layer.
Antibiotic layer 4 includes the fabric formed by bamboo-carbon fibre and aloe fibre blending and the nanoparticle being distributed in fabric
Son 5.Nano-particle 5 is nano zine oxide and nanogold particle, and above nano-particle has good antibacterial effect.Medicine layer 6
It is made up of nanofiber, Chinese medicine is impregnated with nanofiber, can according to circumstances selects to be impregnated with applying for different treatment effects Chinese medicine
Material, accelerate wound healing or accelerate therapeutic effect.Medicine layer 6 has honeycomb surface, and honeycomb surface has honeycomb, honeycomb
The surface in hole is coated with hydrophobic layer 8.Adhesive layer 7 distributes as net shape in the lower section of medicine layer 6, and is glued when in use with skin
Close.
The present invention makes dressing have waterproof effect, and the tab portion 11 that waterproof layer 1 connects, is deposited by setting waterproof layer 1
The replacement of material provide conveniently, only need to gently pull tab portion 11, dressing is quickly separated with skin, avoid traditional dressing with
After skin fitting completely, it is difficult to the defects of finding the point of penetration for opening dressing;The setting of air-permeable layer 2, on the basis of water resistance
On provide airing function, improve comfort;There is antibiotic layer 4 in dressing, greatly strengthen antibacterial effect, nanoparticle
Son 5 plays main antibacterial functions;Medicine layer 6 is made up of nanofiber, increases specific surface area, increases the drugloading rate of dressing
Greatly, honey comb like surface further increases the speed of insoluble drug release, and the setting of hydrophobic layer 8 can prevent medicine by wound
Thing infiltrates, and influences insoluble drug release effect;Adhesive layer 7 distributes as net shape so that and dressing forms adhesive network face with skin, when
When applying external force, it is easy to dressing is separated with skin, avoids that cambium is caused to damage.
Described above is only the preferred embodiment of the present invention, is not intended to limit the invention, it is noted that for this skill
For the those of ordinary skill in art field, without departing from the technical principles of the invention, can also make it is some improvement and
Modification, these improvement and modification also should be regarded as protection scope of the present invention.
Claims (9)
- A kind of 1. Medical composite dressing, it is characterised in that:Including set gradually from bottom to top waterproof layer, air-permeable layer, antibiotic layer, Medicine layer and adhesive layer, the waterproof layer edge are connected with tab portion, the tab portion substantially semicircular in shape, the antibacterial Layer includes fabric and the nano-particle being distributed in the fabric, the medicine layer are made up of nanofiber, the medicine layer With honeycomb surface, the honeycomb surface has honeycomb, and the surface of the honeycomb is coated with hydrophobic layer, the bonding Layer distributes as net shape.
- 2. Medical composite dressing according to claim 1, it is characterised in that:The waterproof layer is made up of plastic film.
- 3. Medical composite dressing according to claim 2, it is characterised in that:The plastic cement be aqueous polyurethane, polyethylene, PLA or makrolon.
- 4. Medical composite dressing according to claim 1, it is characterised in that:The waterproof layer is translucent shape.
- 5. Medical composite dressing according to claim 1, it is characterised in that:The air-permeable layer is including fibrous layer and uniformly Activated carbon granule in the fibrous layer.
- 6. Medical composite dressing according to claim 5, it is characterised in that:The material of the fibrous layer is flax fiber Layer, bamboo-carbon fibre or cotton fiber.
- 7. Medical composite dressing according to claim 1, it is characterised in that:The fabric is by bamboo-carbon fibre and aloe fibre Blending forms.
- 8. Medical composite dressing according to claim 1, it is characterised in that:The nano-particle is nano zine oxide, received One or more in rice Argent grain and nanogold particle.
- 9. Medical composite dressing according to claim 1, it is characterised in that:Chinese medicine is impregnated with the nanofiber.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710726229.7A CN107334579A (en) | 2017-08-22 | 2017-08-22 | A kind of Medical composite dressing |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710726229.7A CN107334579A (en) | 2017-08-22 | 2017-08-22 | A kind of Medical composite dressing |
Publications (1)
Publication Number | Publication Date |
---|---|
CN107334579A true CN107334579A (en) | 2017-11-10 |
Family
ID=60214226
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710726229.7A Pending CN107334579A (en) | 2017-08-22 | 2017-08-22 | A kind of Medical composite dressing |
Country Status (1)
Country | Link |
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CN (1) | CN107334579A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107757027A (en) * | 2017-11-24 | 2018-03-06 | 苏州康孚智能科技有限公司 | A kind of intelligent waterproof composite fabric |
CN109529097A (en) * | 2018-11-08 | 2019-03-29 | 广州润虹医药科技股份有限公司 | A kind of soluble stanching gauze |
CN110559128A (en) * | 2019-08-28 | 2019-12-13 | 孙朋付 | Antibacterial gauze for protecting skin wound surface |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN2621642Y (en) * | 2003-05-27 | 2004-06-30 | 宋鸿谟 | Dressing sheeet having irregular honeycomb-like opening |
CN102860903A (en) * | 2012-10-10 | 2013-01-09 | 无锡莱吉特信息科技有限公司 | Adhesive bandage |
CN203195849U (en) * | 2013-04-11 | 2013-09-18 | 湖南福尔康医用卫生材料股份有限公司 | Novelmedical dressing |
CN204890352U (en) * | 2015-08-20 | 2015-12-23 | 王建传 | Antibiotic woundplast of porous haydite |
CN205181865U (en) * | 2015-10-13 | 2016-04-27 | 广东泰宝医疗科技股份有限公司 | Double -deck compound wound dressing that protects |
CN205181614U (en) * | 2015-12-02 | 2016-04-27 | 南阳市汇博生物技术有限公司 | Dressing of compound biological activity fibre |
CN205215519U (en) * | 2015-09-14 | 2016-05-11 | 山东星之诚生物科技有限公司 | Novel multilayer band -aid |
CN208301795U (en) * | 2017-08-22 | 2019-01-01 | 苏州思彬纳米科技有限公司 | A kind of Medical composite dressing |
-
2017
- 2017-08-22 CN CN201710726229.7A patent/CN107334579A/en active Pending
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN2621642Y (en) * | 2003-05-27 | 2004-06-30 | 宋鸿谟 | Dressing sheeet having irregular honeycomb-like opening |
CN102860903A (en) * | 2012-10-10 | 2013-01-09 | 无锡莱吉特信息科技有限公司 | Adhesive bandage |
CN203195849U (en) * | 2013-04-11 | 2013-09-18 | 湖南福尔康医用卫生材料股份有限公司 | Novelmedical dressing |
CN204890352U (en) * | 2015-08-20 | 2015-12-23 | 王建传 | Antibiotic woundplast of porous haydite |
CN205215519U (en) * | 2015-09-14 | 2016-05-11 | 山东星之诚生物科技有限公司 | Novel multilayer band -aid |
CN205181865U (en) * | 2015-10-13 | 2016-04-27 | 广东泰宝医疗科技股份有限公司 | Double -deck compound wound dressing that protects |
CN205181614U (en) * | 2015-12-02 | 2016-04-27 | 南阳市汇博生物技术有限公司 | Dressing of compound biological activity fibre |
CN208301795U (en) * | 2017-08-22 | 2019-01-01 | 苏州思彬纳米科技有限公司 | A kind of Medical composite dressing |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107757027A (en) * | 2017-11-24 | 2018-03-06 | 苏州康孚智能科技有限公司 | A kind of intelligent waterproof composite fabric |
CN109529097A (en) * | 2018-11-08 | 2019-03-29 | 广州润虹医药科技股份有限公司 | A kind of soluble stanching gauze |
CN109529097B (en) * | 2018-11-08 | 2021-11-16 | 广州润虹医药科技股份有限公司 | Soluble hemostatic gauze |
CN110559128A (en) * | 2019-08-28 | 2019-12-13 | 孙朋付 | Antibacterial gauze for protecting skin wound surface |
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PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171110 |
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RJ01 | Rejection of invention patent application after publication |